PL1926476T3 - Amorficzne stałe dyspersje 7-chloro-N,N,5-trimetylo-4-okso-3-fenylo-3,5-dihydro-4H-pirydazyno[4,5-b]indolo-1-acetamidu - Google Patents

Amorficzne stałe dyspersje 7-chloro-N,N,5-trimetylo-4-okso-3-fenylo-3,5-dihydro-4H-pirydazyno[4,5-b]indolo-1-acetamidu

Info

Publication number: PL1926476T3
Authority: PL; Poland
Prior art keywords: pyridazino; acetamide; indole; dihydro; trimethyl
Prior art date: 2005-08-29

Application number

PL06802215T

Other languages

English (en)

Inventor

Irwin C Jacobs

John D Higgins

Micael Guillot

Nancy M Franson

William L Rocco

Khawla Abdullah Abu-Izza

Original Assignee

Sanofi Aventis Us Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-08-29

Filing date

2006-08-24

Publication date

2013-08-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37499538&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1926476(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-08-24 Application filed by Sanofi Aventis Us Llc filed Critical Sanofi Aventis Us Llc

2013-08-30 Publication of PL1926476T3 publication Critical patent/PL1926476T3/pl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Cardiology (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

PL06802215T 2005-08-29 2006-08-24 Amorficzne stałe dyspersje 7-chloro-N,N,5-trimetylo-4-okso-3-fenylo-3,5-dihydro-4H-pirydazyno[4,5-b]indolo-1-acetamidu PL1926476T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US71215005P	2005-08-29	2005-08-29
EP06802215.1A EP1926476B1 (en)	2005-08-29	2006-08-24	Amorphous solid dispersions of 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5,-dihydro-4h-pyridazino[4,5-b]indole-1-acetamide
PCT/US2006/033022 WO2007027494A2 (en)	2005-08-29	2006-08-24	Morphous solid dispersions of 7-chloro-n,n, 5-trimethyl-4-oxo-3-phenyl-3, 5,-dihydro-4h-pyridazino [4, 5-b] indole-1-acetamide

Publications (1)

Publication Number	Publication Date
PL1926476T3 true PL1926476T3 (pl)	2013-08-30

Family

ID=37499538

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL06802215T PL1926476T3 (pl)	2005-08-29	2006-08-24	Amorficzne stałe dyspersje 7-chloro-N,N,5-trimetylo-4-okso-3-fenylo-3,5-dihydro-4H-pirydazyno[4,5-b]indolo-1-acetamidu

Country Status (31)

Country	Link
US (1)	US7713548B2 (pl)
EP (1)	EP1926476B1 (pl)
JP (1)	JP5026426B2 (pl)
KR (1)	KR20080061354A (pl)
CN (1)	CN101272767B (pl)
AR (1)	AR055615A1 (pl)
AU (1)	AU2006285111B8 (pl)
BR (1)	BRPI0615609A2 (pl)
CA (1)	CA2619438A1 (pl)
CR (1)	CR9750A (pl)
DK (1)	DK1926476T3 (pl)
EA (1)	EA015715B1 (pl)
EC (1)	ECSP088203A (pl)
ES (1)	ES2414434T3 (pl)
HK (1)	HK1124785A1 (pl)
HN (1)	HN2008000360A (pl)
HR (1)	HRP20130533T1 (pl)
IL (1)	IL189587A (pl)
MA (1)	MA29783B1 (pl)
ME (1)	ME01560B (pl)
NO (1)	NO20081364L (pl)
NZ (1)	NZ566313A (pl)
PL (1)	PL1926476T3 (pl)
PT (1)	PT1926476E (pl)
RS (1)	RS52914B (pl)
SI (1)	SI1926476T1 (pl)
TN (1)	TNSN08069A1 (pl)
TW (1)	TWI398250B (pl)
UA (1)	UA93517C2 (pl)
WO (1)	WO2007027494A2 (pl)
ZA (1)	ZA200801893B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LT3091011T (lt)	2006-04-07	2018-04-10	Vertex Pharmaceuticals Incorporated	Atp surišančios kasetės transporterių moduliatoriai
EP2155166A2 (en) *	2007-05-11	2010-02-24	F. Hoffmann-Roche AG	Pharmaceutical compositions for poorly soluble drugs
MX2010009344A (es) *	2008-03-11	2012-09-28	Reddys Lab Ltd Dr	Preparacion de lenalidomida.
AU2009283039A1 (en) *	2008-08-18	2010-02-25	Sanofi-Aventis U.S. Llc	Process for preparing polymorph of 7-chloro-N, N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4H-pyridazin0[4,5-b]indole-1-acetamide
WO2011119984A1 (en) *	2010-03-25	2011-09-29	Vertex Pharmaceuticals Incorporated	Solid forms of (r)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihyderoxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
EP2822539B1 (en)	2012-03-07	2018-11-21	National Institute Of Pharmaceutical Education And Research (NIPER)	Nanocrystalline solid dispersion compositions
KR101986683B1 (ko) *	2012-12-13	2019-06-10	한미약품 주식회사	테트라졸 유도체를 활성 성분으로 포함하는 용해도가 개선된 고체 분산체
WO2015030788A1 (en) *	2013-08-30	2015-03-05	Hewlett-Packard Development Company, L.P.	Comparing real-time movements to pattern profile background
EP3120871B1 (en) *	2014-03-18	2023-06-28	Takeda Pharmaceutical Company Limited	Solid dispersion
SI3925607T1 (sl)	2014-04-15	2023-10-30	Vertex Pharmaceuticals Incorporated	Farmacevtski sestavki za zdravljenje bolezni, ki jih povzroča regulator transmembranske prevodnosti pri cistični fibrozi
US10246461B2 (en)	2016-02-29	2019-04-02	Genentech, Inc.	Dosage form compositions comprising an inhibitor of bruton's tyrosine kinase
CA3066046A1 (en) *	2017-07-04	2019-01-10	Jiangsu Hengrui Medicine Co., Ltd.	Pharmaceutical composition and method for preparing same

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US5091381A (en) *	1991-04-12	1992-02-25	Biomeasure, Inc.	2H-1,3,4-benzotriazepin-2-ones
TW487582B (en) *	1995-08-11	2002-05-21	Nissan Chemical Ind Ltd	Method for converting sparingly water-soluble medical substance to amorphous state
FR2766823B1 (fr) *	1997-07-30	1999-10-08	Synthelabo	Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
DE69837903T2 (de) *	1997-08-11	2008-02-14	Pfizer Products Inc., Groton	Feste pharmazeutische Dispersionen mit erhöhter Bioverfügbarkeit
AUPP278498A0 (en) *	1998-04-03	1998-04-30	Australian Nuclear Science & Technology Organisation	Peripheral benzodiazepine receptor binding agents
FR2788696B1 (fr) *	1999-01-26	2004-03-05	Synthelabo	Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
DE60039377D1 (de) *	1999-02-09	2008-08-21	Pfizer Prod Inc	Zusammensetzungen basischer Arzneistoffe mit verbesserter Bioverfügbarkeit
EP1027886B1 (en) *	1999-02-10	2008-07-09	Pfizer Products Inc.	Pharmaceutical solid dispersions
EP1027887B1 (en) *	1999-02-10	2008-08-13	Pfizer Products Inc.	Matrix controlled release device
EP1120109A3 (en) *	2000-01-24	2002-07-10	Pfizer Products Inc.	Rapidly disintegrating and fast dissolving solid dosage form
FR2829939B3 (fr) *	2001-09-21	2003-11-28	Sanofi Synthelabo	Utilisation du 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5- dihydro-4h-pyridazino(4,5-b)indole-1-acetamide pour la preparation de medicaments destines au traitement de la polyarthrite rhumatoide
CL2004001884A1 (es) *	2003-08-04	2005-06-03	Pfizer Prod Inc	Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
US20050220881A1 (en) *	2003-10-10	2005-10-06	Bvm Holding Co.	Pharmaceutical composition

2006
- 2006-08-24 PL PL06802215T patent/PL1926476T3/pl unknown
- 2006-08-24 ZA ZA200801893A patent/ZA200801893B/xx unknown
- 2006-08-24 WO PCT/US2006/033022 patent/WO2007027494A2/en active Application Filing
- 2006-08-24 AU AU2006285111A patent/AU2006285111B8/en not_active Ceased
- 2006-08-24 EA EA200800713A patent/EA015715B1/ru not_active IP Right Cessation
- 2006-08-24 PT PT68022151T patent/PT1926476E/pt unknown
- 2006-08-24 ES ES06802215T patent/ES2414434T3/es active Active
- 2006-08-24 DK DK06802215.1T patent/DK1926476T3/da active
- 2006-08-24 BR BRPI0615609-6A patent/BRPI0615609A2/pt not_active IP Right Cessation
- 2006-08-24 ME MEP-2013-80A patent/ME01560B/me unknown
- 2006-08-24 CN CN2006800317142A patent/CN101272767B/zh not_active Expired - Fee Related
- 2006-08-24 KR KR1020087004952A patent/KR20080061354A/ko active IP Right Grant
- 2006-08-24 RS RS20130288A patent/RS52914B/en unknown
- 2006-08-24 SI SI200631605T patent/SI1926476T1/sl unknown
- 2006-08-24 EP EP06802215.1A patent/EP1926476B1/en active Active
- 2006-08-24 CA CA002619438A patent/CA2619438A1/en not_active Abandoned
- 2006-08-24 JP JP2008529117A patent/JP5026426B2/ja not_active Expired - Fee Related
- 2006-08-24 NZ NZ566313A patent/NZ566313A/en not_active IP Right Cessation
- 2006-08-24 UA UAA200803944A patent/UA93517C2/ru unknown
- 2006-08-28 AR ARP060103739A patent/AR055615A1/es not_active Application Discontinuation
- 2006-08-29 TW TW095131682A patent/TWI398250B/zh not_active IP Right Cessation
2008
- 2008-02-12 US US12/029,691 patent/US7713548B2/en not_active Expired - Fee Related
- 2008-02-13 TN TNP2008000069A patent/TNSN08069A1/en unknown
- 2008-02-18 IL IL189587A patent/IL189587A/en not_active IP Right Cessation
- 2008-02-19 EC EC2008008203A patent/ECSP088203A/es unknown
- 2008-02-21 CR CR9750A patent/CR9750A/es unknown
- 2008-02-28 HN HN2008000360A patent/HN2008000360A/es unknown
- 2008-03-14 NO NO20081364A patent/NO20081364L/no not_active Application Discontinuation
- 2008-03-17 MA MA30752A patent/MA29783B1/fr unknown
2009
- 2009-03-20 HK HK09102705.3A patent/HK1124785A1/xx not_active IP Right Cessation
2013
- 2013-06-12 HR HRP20130533TT patent/HRP20130533T1/hr unknown

Also Published As

Publication number	Publication date
TWI398250B (zh)	2013-06-11
ECSP088203A (es)	2008-06-30
EP1926476A2 (en)	2008-06-04
PT1926476E (pt)	2013-07-10
WO2007027494A3 (en)	2007-08-02
AU2006285111A1 (en)	2007-03-08
WO2007027494A2 (en)	2007-03-08
CN101272767B (zh)	2012-08-29
HK1124785A1 (pl)	2009-07-24
MA29783B1 (fr)	2008-09-01
HN2008000360A (es)	2011-05-31
RS52914B (en)	2014-02-28
AU2006285111B8 (en)	2012-05-17
ES2414434T3 (es)	2013-07-19
ZA200801893B (en)	2009-08-26
SI1926476T1 (sl)	2013-07-31
EP1926476B1 (en)	2013-04-10
TNSN08069A1 (en)	2009-07-14
AU2006285111B2 (en)	2012-04-26
JP5026426B2 (ja)	2012-09-12
UA93517C2 (en)	2011-02-25
IL189587A0 (en)	2008-08-07
AR055615A1 (es)	2007-08-29
US20080160080A1 (en)	2008-07-03
HRP20130533T1 (en)	2013-07-31
EA200800713A1 (ru)	2008-10-30
JP2009506114A (ja)	2009-02-12
NZ566313A (en)	2011-04-29
CA2619438A1 (en)	2007-03-08
KR20080061354A (ko)	2008-07-02
CR9750A (es)	2008-06-18
US7713548B2 (en)	2010-05-11
CN101272767A (zh)	2008-09-24
IL189587A (en)	2012-12-31
NO20081364L (no)	2008-04-03
EA015715B1 (ru)	2011-10-31
DK1926476T3 (da)	2013-07-01
BRPI0615609A2 (pt)	2011-05-24
TW200727902A (en)	2007-08-01
ME01560B (me)	2014-04-20

Publication	Publication Date	Title
HRP20130533T1 (en)	2013-07-31	Amorphous solid dispersions of 7-chloro-n,n, 5-trimethyl-4-oxo-3-phenyl-3, 5,-dihydro-4h-pyridazino[4,5-b]indole-1-acetamide
IL186881A0 (en)	2008-02-09	Pyrido [2, 3 - d] pyrimidines useful as hcv inhibitors, and methods for the preparation thereof
EP2223921B8 (en)	2013-02-20	2-Thiophen-2-yl-oxazole, 2-Thiophen-2-yl-thiazole and 2-Thiophen-2-yl-1H-imidazole derivatives as antiviral agents
HK1118556A1 (en)	2009-02-13	5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
IL192236A0 (en)	2008-12-29	Aryl-isoxazol-4-yl-imidazo[1,5-a]pyridine derivatives
ZA200809796B (en)	2009-11-25	Pyrazolo [1,5-A]pyrimidines as CDK inhibitors
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