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PL1969125T3 - Mikrorna, które regulują proliferację i różnicowanie komórek mięśniowych - Google Patents

Mikrorna, które regulują proliferację i różnicowanie komórek mięśniowych

Info

Publication number
PL1969125T3
PL1969125T3 PL06845222T PL06845222T PL1969125T3 PL 1969125 T3 PL1969125 T3 PL 1969125T3 PL 06845222 T PL06845222 T PL 06845222T PL 06845222 T PL06845222 T PL 06845222T PL 1969125 T3 PL1969125 T3 PL 1969125T3
Authority
PL
Poland
Prior art keywords
micrornas
differentiation
cell proliferation
muscle cell
regulate muscle
Prior art date
Application number
PL06845222T
Other languages
English (en)
Inventor
Da-Zhi Wang
Jianfu Chen
Original Assignee
Univ North Carolina Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina Chapel Hill filed Critical Univ North Carolina Chapel Hill
Publication of PL1969125T3 publication Critical patent/PL1969125T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/10—Production naturally occurring

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL06845222T 2005-12-12 2006-12-12 Mikrorna, które regulują proliferację i różnicowanie komórek mięśniowych PL1969125T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74954405P 2005-12-12 2005-12-12
PCT/US2006/047255 WO2007070483A2 (en) 2005-12-12 2006-12-12 Micrornas that regulate muscle cell proliferation and differentiation
EP06845222A EP1969125B1 (en) 2005-12-12 2006-12-12 Micrornas that regulate muscle cell proliferation and differentiation

Publications (1)

Publication Number Publication Date
PL1969125T3 true PL1969125T3 (pl) 2012-11-30

Family

ID=38163464

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06845222T PL1969125T3 (pl) 2005-12-12 2006-12-12 Mikrorna, które regulują proliferację i różnicowanie komórek mięśniowych

Country Status (14)

Country Link
US (3) US8431542B2 (pl)
EP (3) EP2497827A1 (pl)
JP (3) JP2009519339A (pl)
KR (2) KR20140130562A (pl)
CN (2) CN104027818A (pl)
AU (1) AU2006326517B2 (pl)
BR (1) BRPI0619755A2 (pl)
CA (2) CA2634046A1 (pl)
DK (1) DK1969125T3 (pl)
ES (1) ES2387250T3 (pl)
NZ (3) NZ593688A (pl)
PL (1) PL1969125T3 (pl)
PT (1) PT1969125E (pl)
WO (1) WO2007070483A2 (pl)

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KR20200096610A (ko) * 2017-12-08 2020-08-12 유니버시티 오브 워싱톤 카르디올리핀 리모델링 및 심근세포 성숙을 검출 및 촉진하기 위한 방법 및 조성물 및 미토콘드리아 기능장애를 치료하는 관련 방법
EP3765610A4 (en) * 2018-03-14 2022-01-19 Beth Israel Deaconess Medical Center MICRO-RNA AND OBESITY
CN108690846A (zh) * 2018-04-17 2018-10-23 上海大学 抑制MiR-29b基因表达的应用
CN108823209B (zh) * 2018-07-18 2021-04-09 华中农业大学 骨骼肌特异性启动子及应用
KR20210102870A (ko) 2018-08-30 2021-08-20 테나야 테라퓨틱스, 인코포레이티드 미오카르딘 및 ascl1을 사용한 심장 세포 재프로그래밍
CN111041052B (zh) * 2019-12-30 2021-05-28 嘉兴学院 mir-206在抑制猪脂肪细胞内的甘油三酯生成以及瘦肉猪育种中的应用
BR112022017551A2 (pt) * 2020-03-02 2022-11-16 Tenaya Therapeutics Inc Controle de vetor genético por micrornas expressos por cardiomiócito
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CN112266912A (zh) * 2020-10-22 2021-01-26 上海大学 靶向miR-29b的gRNA、AAV8-CRISPR/Cas9系统及其应用
WO2023034966A1 (en) * 2021-09-03 2023-03-09 The University Of North Carolina At Chapel Hill Compositions and methods of using the same for treating disorders associated with thymosin βeta 4
CN114480672B (zh) * 2022-02-22 2023-08-15 青岛农业大学 一种通过miR-145筛选高产肉率碱地黑牛的方法
CN114748497B (zh) * 2022-04-27 2024-10-18 广州市妇女儿童医疗中心 一种调控子宫肌收缩的miRNA分子miR-206及其应用
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CN117511884B (zh) * 2023-12-06 2024-06-11 中国农业科学院兰州畜牧与兽药研究所 Rtl1在抑制牦牛成肌细胞分化中的应用

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Also Published As

Publication number Publication date
JP5740460B2 (ja) 2015-06-24
EP1969125B1 (en) 2012-06-13
NZ593688A (en) 2013-01-25
EP1969125A4 (en) 2010-10-20
NZ569738A (en) 2012-03-30
AU2006326517A1 (en) 2007-06-21
WO2007070483A3 (en) 2008-07-24
DK1969125T3 (da) 2012-07-23
US20130225665A1 (en) 2013-08-29
ES2387250T3 (es) 2012-09-19
US20100292297A1 (en) 2010-11-18
JP2014094943A (ja) 2014-05-22
US9072764B2 (en) 2015-07-07
KR101485071B1 (ko) 2015-01-26
JP2009519339A (ja) 2009-05-14
AU2006326517B2 (en) 2013-02-21
NZ602571A (en) 2014-03-28
EP1969125A2 (en) 2008-09-17
WO2007070483A2 (en) 2007-06-21
US8431542B2 (en) 2013-04-30
CN104027818A (zh) 2014-09-10
KR20080080177A (ko) 2008-09-02
CA2903764A1 (en) 2007-06-21
JP5796027B2 (ja) 2015-10-21
EP2497827A1 (en) 2012-09-12
CN101448942B (zh) 2014-04-23
EP2671949A1 (en) 2013-12-11
BRPI0619755A2 (pt) 2011-10-18
CN101448942A (zh) 2009-06-03
JP2013126996A (ja) 2013-06-27
WO2007070483A9 (en) 2011-06-16
US20130225658A1 (en) 2013-08-29
CA2634046A1 (en) 2007-06-21
KR20140130562A (ko) 2014-11-10
PT1969125E (pt) 2012-08-16

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