Nothing Special   »   [go: up one dir, main page]

PL1831242T3 - Zmniejszanie zawartości zanieczyszczeń białkowych w kompozycjach zawierających zależne od witaminy K białko będące przedmiotem zainteresowania - Google Patents

Zmniejszanie zawartości zanieczyszczeń białkowych w kompozycjach zawierających zależne od witaminy K białko będące przedmiotem zainteresowania

Info

Publication number
PL1831242T3
PL1831242T3 PL05850495T PL05850495T PL1831242T3 PL 1831242 T3 PL1831242 T3 PL 1831242T3 PL 05850495 T PL05850495 T PL 05850495T PL 05850495 T PL05850495 T PL 05850495T PL 1831242 T3 PL1831242 T3 PL 1831242T3
Authority
PL
Poland
Prior art keywords
protein
vitamin
interest
compositions
reduction
Prior art date
Application number
PL05850495T
Other languages
English (en)
Inventor
Janus Krarup
Thomas Budde Hansen
Anne Charlotte Arentsen
Daniel E Rasmussen
Are Bogsnes
Arne Staby
Haleh Ahmadian
Susanne Bang
Original Assignee
Novo Nordisk Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk Healthcare Ag filed Critical Novo Nordisk Healthcare Ag
Publication of PL1831242T3 publication Critical patent/PL1831242T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL05850495T 2004-12-23 2005-12-23 Zmniejszanie zawartości zanieczyszczeń białkowych w kompozycjach zawierających zależne od witaminy K białko będące przedmiotem zainteresowania PL1831242T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200402008 2004-12-23
EP05850495A EP1831242B1 (en) 2004-12-23 2005-12-23 Reduction of the content of protein contaminants in compositions comprising a vitamin k-dependent protein of interest
PCT/EP2005/057145 WO2006067230A1 (en) 2004-12-23 2005-12-23 Reduction of the content of protein contaminants in compositions comprising a vitamin k-dependent protein of interest

Publications (1)

Publication Number Publication Date
PL1831242T3 true PL1831242T3 (pl) 2013-04-30

Family

ID=36168465

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05850495T PL1831242T3 (pl) 2004-12-23 2005-12-23 Zmniejszanie zawartości zanieczyszczeń białkowych w kompozycjach zawierających zależne od witaminy K białko będące przedmiotem zainteresowania

Country Status (13)

Country Link
US (1) US9187549B2 (pl)
EP (2) EP2360171A1 (pl)
JP (2) JP2008525381A (pl)
KR (2) KR101364001B1 (pl)
CN (1) CN101098883B (pl)
AU (1) AU2005318106B2 (pl)
BR (1) BRPI0519626A2 (pl)
CA (1) CA2592054A1 (pl)
ES (1) ES2395544T3 (pl)
MX (1) MX2007007356A (pl)
PL (1) PL1831242T3 (pl)
RU (1) RU2460735C2 (pl)
WO (1) WO2006067230A1 (pl)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2360171A1 (en) 2004-12-23 2011-08-24 Novo Nordisk Health Care AG Reduction of the content of protein contaminants in compositions comprising a vitamin K-dependent protein of interest
JP5147692B2 (ja) 2005-07-13 2013-02-20 ノボ ノルディスク ヘルス ケア アーゲー 治療用タンパク質生成のための宿主細胞タンパク質ノックアウト細胞
AT502691A1 (de) * 2005-10-24 2007-05-15 Univ Fuer Weiterbildung Krems Extrakorporales blut- oder plasmareinigungssystem
US9956272B2 (en) 2007-05-30 2018-05-01 Bio Products Laboratory Limited Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same
GB0710321D0 (en) * 2007-05-30 2007-07-11 Nhs Blood & Transplant Method
KR101293504B1 (ko) * 2007-07-11 2013-08-07 노보 노르디스크 에이/에스 혼합형 또는 다중형 수지를 사용하는 인자 ｖⅰⅰⅰ의 정제
TWI538916B (zh) 2008-04-11 2016-06-21 介控生化科技公司 經修飾的因子vii多肽和其用途
ES2576109T3 (es) * 2008-12-02 2016-07-05 Novo Nordisk Health Care Ag Purificación de polipéptidos
FR2946348B1 (fr) * 2009-06-05 2011-08-05 Lab Francais Du Fractionnement Procede de preparation d'une composition de complexe prothrombique a haut degre de purete
US8129139B2 (en) * 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
CA2783207A1 (en) * 2009-12-18 2011-06-23 Csl Ltd. Method of purifying polypeptides
RU2012133474A (ru) 2010-01-18 2014-02-27 Ново Нордиск Хелс Кеа Аг Очистка факторов свертывания крови
AU2011234521B2 (en) * 2010-03-30 2015-04-23 Octapharma Ag A process for purifying Vitamin K dependent proteins such as coagulation factor IX
KR101780518B1 (ko) * 2010-04-29 2017-09-21 박스알타 인코퍼레이티드 음이온 교환 수지상에서의 2가 양이온 결합 단백질의 정제 방법
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient
CN102161701A (zh) * 2011-01-28 2011-08-24 上海兴迪金生物技术有限公司 从细胞培养液或血浆组分中分离纯化高纯度活化凝血七因子的方法
JP2011172602A (ja) * 2011-06-15 2011-09-08 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
ES2700933T3 (es) * 2011-10-14 2019-02-20 Baxalta GmbH Purificación de proteínas mediante cromatografía de intercambio aniónico
LT2748179T (lt) * 2011-10-14 2022-04-11 Takeda Pharmaceutical Company Limited Baltymų gryninimas anijonų mainų chromatografija
SI2970376T1 (sl) 2013-03-15 2018-09-28 Baxalta Incorporated Metoda čiščenja za vitamin k odvisne proteine z anionsko izmenjevalno kromatografijo
WO2014181549A1 (ja) 2013-05-10 2014-11-13 株式会社デンソー 燃料噴射制御装置および燃料噴射システム
JP5750471B2 (ja) * 2013-05-22 2015-07-22 Ｊｃｒファーマ株式会社 組換え体ヒトｆｓｈの製造方法
WO2016207328A1 (en) * 2015-06-24 2016-12-29 Glycotope Gmbh PROCESS FOR THE PURIFICATION OF γ-CARBOXYLATED POLYPEPTIDES
WO2018165933A1 (zh) * 2017-03-16 2018-09-20 深圳先进技术研究院 调节糖代谢的多肽及其用途
KR102432962B1 (ko) 2017-03-16 2022-08-12 쉔첸 인스티튜트스 오브 어드밴스드 테크놀로지 에너지 대사를 조절하는 폴리펩티드 및 그 용도
EP3590528A1 (en) * 2018-07-06 2020-01-08 Octapharma AG Fx activation process and its use in the preparation of a fxa composition
CN114728044A (zh) 2019-08-15 2022-07-08 介控生化科技公司 用于皮下施用和按需求治疗的经修饰的因子vii多肽

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485711D1 (de) * 1983-03-04 1992-06-17 Scripps Clinic Res Immunoadsorbens und verfahren zur zurueckgewinnung von vitamin-k-abhaengigen proteinen mittels dieses adsorbens.
US5055557A (en) 1983-03-04 1991-10-08 Scripps Clinic & Research Foundation Ultrapurification of factor IX and other vitamin K-dependent proteins
GR860984B (en) 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
US4721572A (en) 1985-07-12 1988-01-26 Miles Laboratories, Inc. Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices
JPH0759600B2 (ja) * 1986-12-15 1995-06-28 帝人株式会社 ヒト・プロテインｓに対するモノクローナル抗体
JPH01231893A (ja) * 1988-03-14 1989-09-18 Fuji Yakuhin Kogyo Kk 抗ヒトプロテインｓモノクローナル抗体およびその利用
US4981952A (en) 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
US5077214A (en) 1989-07-07 1991-12-31 The Texas A&M University System Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells
JP2824430B2 (ja) 1989-08-02 1998-11-11 財団法人化学及血清療法研究所 血液凝固第▲ｖｉｉ▼因子または活性型血液凝固第▲ｖｉｉ▼因子の調製方法
US5580560A (en) 1989-11-13 1996-12-03 Novo Nordisk A/S Modified factor VII/VIIa
AT402261B (de) 1991-01-25 1997-03-25 Immuno Ag Komplex enthaltend den gerinnungsfaktor ix
DE69329682T2 (de) 1992-08-27 2001-05-17 Stichting Sanquin Bloedvoorziening, Amsterdam Antikoerper spezifisch fur ein haemostatisches protein; seine verwendung zur isolation von intaktem protein; haemostatische zusammensetzungen ohne proteolytische spaltprodukte des proteins
DK38293D0 (da) 1993-03-31 1993-03-31 Novo Nordisk As Fremstilling af proteiner
DE4342132C1 (de) 1993-12-10 1994-11-03 Octapharma Ag Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie
DE4406515C1 (de) * 1994-02-28 1995-10-19 Immuno Ag Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine
GB9519197D0 (en) 1995-09-20 1995-11-22 Affinity Chromatography Ltd Novel affinity ligands and their use
US6117996A (en) 1995-09-20 2000-09-12 Novo Nordisk A/S Triazine based ligands and use thereof
JP3745805B2 (ja) 1995-10-24 2006-02-15 日本ケミカルリサーチ株式会社 トロンボモジュリンの精製方法
DE19538715A1 (de) 1995-10-18 1997-04-30 Behringwerke Ag Verfahren zur Reinigung von Faktor VII und aktiviertem Faktor VII
DK1754718T3 (da) 1996-04-24 2011-07-18 Univ Michigan Inaktiveringsresistent faktor VIII
US7247708B2 (en) 1997-10-23 2007-07-24 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6747003B1 (en) 1997-10-23 2004-06-08 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6693075B1 (en) 1997-10-23 2004-02-17 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
US6017882A (en) 1997-10-23 2000-01-25 Regents Of The University Of Minnesota Modified vitamin K-dependent polypeptides
JP2000143692A (ja) * 1998-11-11 2000-05-26 Fujimori Kogyo Co Ltd モノクローナル抗体によって精製されたトロンビン基質または阻害剤の精製方法
ATE509028T1 (de) 1999-03-15 2011-05-15 Novo Nordisk As Ionen-austausch-chromatographische trennung von glp-1 und verwandten peptiden
WO2001004287A1 (en) 1999-07-07 2001-01-18 Maxygen Aps A method for preparing modified polypeptides
JP4451514B2 (ja) 1999-08-24 2010-04-14 財団法人化学及血清療法研究所 血液凝固第ｖｉｉ因子改変体
US6806063B2 (en) 2000-02-11 2004-10-19 Maxygen Aps Factor VII or VIIa-like molecules
SE0000675D0 (sv) 2000-03-02 2000-03-02 Protease Ab Monoclonal antibodies
JP2001247599A (ja) * 2000-03-07 2001-09-11 Fujimori Kogyo Co Ltd ポリペプチド、それを用いた血液凝固因子吸着体、該吸着体を用いた血液凝固因子の精製方法、および該ポリペプチドを含有する血栓形成予防剤
US6952212B2 (en) 2000-03-24 2005-10-04 Telefonaktiebolaget Lm Ericsson (Publ) Frame decimation for structure from motion
EP1282693B1 (en) 2000-05-03 2010-10-20 Novo Nordisk Health Care AG Human coagulation factor vii variants
US6423826B1 (en) 2000-06-30 2002-07-23 Regents Of The University Of Minnesota High molecular weight derivatives of vitamin K-dependent polypeptides
US20030211094A1 (en) 2001-06-26 2003-11-13 Nelsestuen Gary L. High molecular weight derivatives of vitamin k-dependent polypeptides
IL154520A0 (en) 2000-09-13 2003-09-17 Novo Nordisk As Human coagulation factor vii variants
IL154880A0 (en) * 2000-10-02 2003-10-31 Novo Nordisk As Method for the production of vitamin k-dependent proteins
AU2002218029A1 (en) 2000-11-09 2002-05-21 The Scripps Research Institute Modified factor viia
RU2321633C2 (ru) * 2001-02-16 2008-04-10 Ново Нордиск Хелт Кэр Аг Способ получения витамин к-зависимых белков
CA2441580A1 (en) 2001-03-22 2002-10-03 Novo Nordisk Health Care Ag Coagulation factor vii derivatives
EP1432794B1 (en) 2001-09-27 2011-11-09 Novo Nordisk Health Care AG Human coagulation factor vii polypeptides
JP4351049B2 (ja) 2001-10-02 2009-10-28 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 真核細胞中で組換えタンパク質を生産する方法
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US7265084B2 (en) 2001-10-10 2007-09-04 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
US7125843B2 (en) 2001-10-19 2006-10-24 Neose Technologies, Inc. Glycoconjugates including more than one peptide
CN102180944A (zh) 2001-10-10 2011-09-14 诺和诺德公司 肽的重构和糖缀合
US7265085B2 (en) 2001-10-10 2007-09-04 Neose Technologies, Inc. Glycoconjugation methods and proteins/peptides produced by the methods
SI1499719T1 (sl) 2002-04-30 2011-03-31 Bayer Healthcare Llc Polipeptidne variante faktorja VII ali VIIa
WO2003092588A2 (en) 2002-04-30 2003-11-13 Merck & Co., Inc. 4-azasteroid derivatives as androgen receptor modulators
AU2003266214A1 (en) 2002-09-25 2004-04-19 Novo Nordisk A/S Human coagulation factor vii polypeptides
DE60336741D1 (de) 2002-09-30 2011-05-26 Bayer Healthcare Llc FVII- ODER FVIIa-VARIANTEN MIT ERHÖHTER KOAGULATIONSWIRKUNG
EP2360171A1 (en) 2004-12-23 2011-08-24 Novo Nordisk Health Care AG Reduction of the content of protein contaminants in compositions comprising a vitamin K-dependent protein of interest

Also Published As

Publication number Publication date
KR101364001B1 (ko) 2014-02-17
JP2013100300A (ja) 2013-05-23
MX2007007356A (es) 2007-08-14
RU2460735C2 (ru) 2012-09-10
JP2008525381A (ja) 2008-07-17
JP5866274B2 (ja) 2016-02-17
WO2006067230A1 (en) 2006-06-29
EP2360171A1 (en) 2011-08-24
KR20070100732A (ko) 2007-10-11
EP1831242A1 (en) 2007-09-12
AU2005318106A1 (en) 2006-06-29
EP1831242B1 (en) 2012-09-26
ES2395544T3 (es) 2013-02-13
US20080207880A1 (en) 2008-08-28
CA2592054A1 (en) 2006-06-29
US9187549B2 (en) 2015-11-17
CN101098883A (zh) 2008-01-02
AU2005318106B2 (en) 2011-11-03
KR20130128013A (ko) 2013-11-25
RU2007122413A (ru) 2009-01-27
BRPI0519626A2 (pt) 2009-02-25
CN101098883B (zh) 2013-01-23

Similar Documents

Publication Publication Date Title
PL1831242T3 (pl) Zmniejszanie zawartości zanieczyszczeń białkowych w kompozycjach zawierających zależne od witaminy K białko będące przedmiotem zainteresowania
GB0422525D0 (en) Dermatological compositions and methods
EP1750682A4 (en) NUTRITIONAL FORMULATIONS
PL1940240T3 (pl) Kompozycje izolatu białka i ich zastosowania
ZA200800136B (en) Oxidation method and compositions thereof
EP1895838A4 (en) COMPOSITIONS AND METHODS
GB0505446D0 (en) Polishing composition and polishing method
SG115831A1 (en) Polishing composition and polishing method
GB0522287D0 (en) Method and compositions
ZA200704295B (en) Arthrospira-based compositions and uses thereof
GB2412919B (en) Polishing composition and polishing method
SG131098A1 (en) Polishing composition and polishing method
IL184062A0 (en) Visco-supplement composition and methods
EP1791855A4 (en) METHODS AND COMPOSITIONS ASSOCIATED WITH ARGONAUTE PROTEINS
SG115786A1 (en) Polishing composition and polishing method
GB0417359D0 (en) Improvements in compositions
GB0516058D0 (en) New protein isoforms and uses thereof
GB0401182D0 (en) Improvements in and relating to conveyors
GB0524927D0 (en) Compositions and method
GB0419295D0 (en) Methods and compositions to prevent neuronal degeneration
ZA200706038B (en) Visco-supplement composition and methods
EP1898956A4 (en) ANTITUMORAL COMPOSITIONS AND METHOD
GB0501348D0 (en) Compositions and methods
GB0511235D0 (en) Compositions and method
EP1924257A4 (en) STABILIZED 3-HYDROXYFLAVAN COMPOSITIONS AND METHOD THEREFOR