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PE20200150A1 - Uso de antagonistas de klk5 para el tratamiento de una enfermedad - Google Patents

Uso de antagonistas de klk5 para el tratamiento de una enfermedad

Info

Publication number
PE20200150A1
PE20200150A1 PE2019002075A PE2019002075A PE20200150A1 PE 20200150 A1 PE20200150 A1 PE 20200150A1 PE 2019002075 A PE2019002075 A PE 2019002075A PE 2019002075 A PE2019002075 A PE 2019002075A PE 20200150 A1 PE20200150 A1 PE 20200150A1
Authority
PE
Peru
Prior art keywords
treatment
disease
domains
seq
klk5
Prior art date
Application number
PE2019002075A
Other languages
English (en)
Inventor
Amy Dressen
David B Iaea
Moulay Hicham Alaoui Ismaili
Janet K Jackman
Robert A Lazarus
Kelly Loyet
Henry R Maun
Brian L Yaspan
Tangsheng Yi
Joseph R Arron
Hilda Y Hernandez-Barry
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20200150A1 publication Critical patent/PE20200150A1/es

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2319/00—Fusion polypeptide
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    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96402—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals
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    • G01N2333/96408—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from non-mammals in general with EC number
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Referida a un polipeptido de fusion a Fc de SPINK que comprende uno o mas dominios de SPINK5 o SPINK9, donde los dominios de SPINK5 comprenden una secuencia que se selecciona de SEQ ID NO:17 y SEQ ID NO:22 y los dominios de SPINK9 comprenden SEQ ID NO:28. Dichos polipeptidos inhiben la actividad de KLK5, siendo utiles en el tratamiento o diagnostico del asma o sindrome de Netherton. Tambien esta referida a composiciones farmaceuticas que comprenden dichos polipeptidos
PE2019002075A 2017-04-21 2018-04-20 Uso de antagonistas de klk5 para el tratamiento de una enfermedad PE20200150A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762488515P 2017-04-21 2017-04-21
PCT/US2018/028637 WO2018195472A1 (en) 2017-04-21 2018-04-20 Use of klk5 antagonists for treatment of a disease

Publications (1)

Publication Number Publication Date
PE20200150A1 true PE20200150A1 (es) 2020-01-17

Family

ID=62223201

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019002075A PE20200150A1 (es) 2017-04-21 2018-04-20 Uso de antagonistas de klk5 para el tratamiento de una enfermedad

Country Status (14)

Country Link
US (2) US20190078160A1 (es)
EP (1) EP3624820A1 (es)
JP (2) JP7248588B2 (es)
KR (1) KR20190141686A (es)
CN (1) CN110536691A (es)
AU (1) AU2018254586A1 (es)
CA (1) CA3059615A1 (es)
CR (1) CR20190480A (es)
MA (1) MA49131A (es)
MX (1) MX2019012419A (es)
PE (1) PE20200150A1 (es)
SG (1) SG11201909048TA (es)
TW (1) TW201841656A (es)
WO (1) WO2018195472A1 (es)

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CA3059615A1 (en) 2018-10-25
MA49131A (fr) 2020-03-25
US20230416825A1 (en) 2023-12-28
CR20190480A (es) 2019-11-20
US20190078160A1 (en) 2019-03-14
CN110536691A (zh) 2019-12-03
JP7248588B2 (ja) 2023-03-29
AU2018254586A1 (en) 2019-10-17
MX2019012419A (es) 2019-12-05
WO2018195472A1 (en) 2018-10-25
TW201841656A (zh) 2018-12-01
JP2020517628A (ja) 2020-06-18
KR20190141686A (ko) 2019-12-24

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