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PE20160998A1 - Derivados de n-((3-(n-hidroxiformamido)propanamido)metil)furan-2-carboxamida - Google Patents

Derivados de n-((3-(n-hidroxiformamido)propanamido)metil)furan-2-carboxamida

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Publication number
PE20160998A1
PE20160998A1 PE2016001113A PE2016001113A PE20160998A1 PE 20160998 A1 PE20160998 A1 PE 20160998A1 PE 2016001113 A PE2016001113 A PE 2016001113A PE 2016001113 A PE2016001113 A PE 2016001113A PE 20160998 A1 PE20160998 A1 PE 20160998A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
formula
hydroxiformide
propanamide
Prior art date
Application number
PE2016001113A
Other languages
English (en)
Inventor
Sarah E Dowdell
Hilary Schenck Eidam
Mark Elban
Ryan Michael Fox
Marlys Hammond
Mark A Hilfiker
Guosen Ye
Lara S Kallander
Brian Griffin Lawhorn
Sharada Manns
Joanne Philp
David G Washburn
Tram H Hoang
Original Assignee
Glaxosmithkline Intellectual Property (No 2) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Intellectual Property (No 2) Ltd filed Critical Glaxosmithkline Intellectual Property (No 2) Ltd
Publication of PE20160998A1 publication Critical patent/PE20160998A1/es

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    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Se refiere a compuestos de Formula (I) o sales de los mismos, donde R1 es H, alquilo C1–C4 o hidroxialquilo C1–C4; R2 es H, alquilo C1–C11, alquil (C1–C3)–cicloalquilo (C3–C6), alquil (C1–C3)–fenilo, entre otros; y R3 es: (a) fenilo opcionalmente sustituido con 1 a 3 grupos seleccionados independientemente entre alquilo C1–C6, ciclopropilo, CONH2, NH2, SH, COOH, entre otros; o (b) heteroarilo opcionalmente sustituido con 1 o 2 grupos seleccionados independientemente entre alquilo C1–C4, alcoxi C1–C4, oxo, COOH, entre otros. Tambien se refiere a composiciones y combinaciones farmaceuticas comprendiendo dichos compuestos de Formula (I). Dichos compuestos de Formula (I) son inhibidores de BMP1, TLL1 o TLL2, por lo cual son utiles en el tratamiento de enfermedades asociadas con fibrosis (infarto de miocardio, arritmias cardiacas, insuficiencia renal cronica, fibrosis pulmonar idiopatica, cirrosis, entre otros), distrofias musculares, entre otras
PE2016001113A 2014-01-10 2015-01-09 Derivados de n-((3-(n-hidroxiformamido)propanamido)metil)furan-2-carboxamida PE20160998A1 (es)

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US (2) US10450288B2 (es)
EP (1) EP3092233A1 (es)
JP (2) JP2017507915A (es)
KR (1) KR20160106684A (es)
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AU (1) AU2015205370B2 (es)
BR (1) BR112016016130A2 (es)
CA (1) CA2936467A1 (es)
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MX (1) MX2016009064A (es)
PE (1) PE20160998A1 (es)
PH (1) PH12016501349A1 (es)
SG (1) SG11201605539SA (es)
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Publication number Priority date Publication date Assignee Title
JP2017507915A (ja) * 2014-01-10 2017-03-23 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ ヒドロキシホルムアミド誘導体およびそれらの使用
WO2017006295A1 (en) * 2015-07-08 2017-01-12 Glaxosmithkline Intellectual Property (No.2) Limited Hydroxy formamide derivatives and their use
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