Nothing Special   »   [go: up one dir, main page]

PE20110561A1 - Anticuerpos contra il-6 - Google Patents

Anticuerpos contra il-6

Info

Publication number
PE20110561A1
PE20110561A1 PE2010001057A PE2010001057A PE20110561A1 PE 20110561 A1 PE20110561 A1 PE 20110561A1 PE 2010001057 A PE2010001057 A PE 2010001057A PE 2010001057 A PE2010001057 A PE 2010001057A PE 20110561 A1 PE20110561 A1 PE 20110561A1
Authority
PE
Peru
Prior art keywords
seq
set forth
referred
disorder
antibodies against
Prior art date
Application number
PE2010001057A
Other languages
English (en)
Inventor
Arvind Rajpal
Madhav Devalaraja
Kristopher Toy
Lan Yang
Halichun Huang
Jun Z Zhang
Peter Brams
Brigitte Devaux
David Passmore
Original Assignee
Bristol Myers Squibb Co
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41431517&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110561(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co, Pfizer filed Critical Bristol Myers Squibb Co
Publication of PE20110561A1 publication Critical patent/PE20110561A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)

Abstract

REFERIDA AUN ANTICUERPO MONOCLONAL HUMANO AISLADO O SUS PORCIONES FIJADORAS DE ANTIGENO QUE COMPRENDE UNA SECUENCIA DE AMINOACIDOS DE DOMINO DE CADENA PESADA VARIABLE (VH) QUE COMPRENDE: A) VH CDR1 TAL COMO SE ESTABLECE EN SEQ ID NO:5, SEQ ID NO:35, VH CDR2 TAL COMO SE ESTABLECE EN SEQ ID NO:6, VH CDR3 TAL COMO SE ESTABLECE EN SEQ ID NO:7, SEQ ID NO:41, SEQ ID NO: 44 Y SEQ ID NO:45. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHO ANTICUERPO ES UTIL EN EL TRATAMIENTO DE TRASTORNO INFLAMATORIO, TRASTORNO ALERGICO, TRASTORNO AUTOINMUNE, DOLOR NEUROPATICO, ENTRE OTROS
PE2010001057A 2008-06-18 2009-06-10 Anticuerpos contra il-6 PE20110561A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7343008P 2008-06-18 2008-06-18
US12/480,991 US8188235B2 (en) 2008-06-18 2009-06-09 Antibodies to IL-6 and their uses

Publications (1)

Publication Number Publication Date
PE20110561A1 true PE20110561A1 (es) 2011-08-11

Family

ID=41431517

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2013002176A PE20140825A1 (es) 2008-06-18 2009-06-10 Anticuerpos contra il-6 y sus usos
PE2010001057A PE20110561A1 (es) 2008-06-18 2009-06-10 Anticuerpos contra il-6

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PE2013002176A PE20140825A1 (es) 2008-06-18 2009-06-10 Anticuerpos contra il-6 y sus usos

Country Status (23)

Country Link
US (4) US8188235B2 (es)
EP (1) EP2291404A1 (es)
JP (2) JP2011524750A (es)
KR (1) KR20110031152A (es)
CN (2) CN104387471A (es)
AR (1) AR072167A1 (es)
AU (1) AU2009260320B2 (es)
BR (1) BRPI0914943A2 (es)
CA (1) CA2724257A1 (es)
CO (1) CO6351748A2 (es)
HK (1) HK1155184A1 (es)
IL (2) IL208532A0 (es)
MX (1) MX2010012272A (es)
NZ (1) NZ588469A (es)
PA (1) PA8830701A1 (es)
PE (2) PE20140825A1 (es)
PH (1) PH12013502205A1 (es)
RU (1) RU2011101589A (es)
SG (1) SG194358A1 (es)
TW (1) TW201002348A (es)
UY (1) UY31904A (es)
WO (1) WO2009155180A1 (es)
ZA (1) ZA201006979B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8188235B2 (en) 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
KR20110094307A (ko) * 2008-11-13 2011-08-23 펨타 파마슈티컬스, 인크. 인간화된 항-ｉｌ-6 항체
JP5933264B2 (ja) 2009-07-16 2016-06-08 サンスター株式会社 プロテオグリカン含有物
EP2547352A4 (en) 2010-03-15 2013-10-09 Stealth Peptides Int Inc COMBINATION THERAPIES USING CYCLOSPORINE AND AROMATIC CATIONIC PEPTIDES
WO2011133748A1 (en) * 2010-04-21 2011-10-27 University Of Medicine And Dentistry Of New Jersey Treatments for cellular proliferative disorders and identification thereof
CN103261222B (zh) * 2010-09-10 2017-07-28 医疗免疫有限公司 抗体衍生物
US9284359B2 (en) 2011-01-19 2016-03-15 Hirosaki University Method for mass preparation of proteoglycan
TWI452688B (zh) 2011-12-27 2014-09-11 Ind Tech Res Inst 可撓式輻射感測器
WO2013175276A1 (en) * 2012-05-23 2013-11-28 Argen-X B.V Il-6 binding molecules
SG10201700525PA (en) * 2012-07-25 2017-02-27 Univ Hirosaki Composition for preventing or treating osteoarthritis
AU2013335004B2 (en) * 2012-10-22 2018-06-28 Oneness Biotech Co. LTD Antibodies to interleukin-6 and uses thereof
AU2014265624B2 (en) * 2013-05-15 2019-09-12 Medimmune Limited Purification of recombinantly produced polypeptides
US9268032B2 (en) 2014-05-12 2016-02-23 Industrial Technology Research Institute Electrical radiography imaging system and method thereof
WO2015187499A1 (en) * 2014-06-03 2015-12-10 Gilead Sciences, Inc. Use of an ask1 inhibitor for the treatment of liver disease, optionally in combination with a loxl2 inhibitor
CA2916283A1 (en) 2015-01-09 2016-07-09 Pfizer Inc. Dosage regimen for madcam antagonists
NZ739392A (en) 2015-07-31 2019-10-25 Medimmune Ltd Methods for treating hepcidin-mediated disorders
JOP20170013B1 (ar) * 2016-01-22 2021-08-17 Merck Sharp & Dohme أجسام xi مضادة لعامل مضاد للتجلط
CN116425879A (zh) 2016-06-14 2023-07-14 默沙东有限责任公司 抗-凝血因子xi抗体
AU2018214554C1 (en) 2017-02-01 2022-12-15 Novo Nordisk A/S Treatment of diuretic resistance
CN109867723B (zh) * 2017-12-05 2022-06-17 南京金斯瑞生物科技有限公司 抗人il6单克隆抗体及其制备方法和用途
AU2019205936B2 (en) * 2018-01-05 2022-09-15 Novo Nordisk A/S Methods for treating IL-6 mediated inflammation without immunosuppression
CN110655576A (zh) * 2019-11-13 2020-01-07 武汉华美生物工程有限公司 Il-6重组单克隆抗体及其制备方法和应用
WO2024102732A1 (en) * 2022-11-11 2024-05-16 Tourmaline Bio, Inc. Methods for the treatment of cardiovascular disease
WO2024112527A2 (en) * 2022-11-23 2024-05-30 Tourmaline Bio, Inc. Methods for the treatment of thyroid eye disease
WO2024112561A1 (en) * 2022-11-23 2024-05-30 Tourmaline Bio, Inc. Methods for the treatment of myasthenia gravis
WO2024129468A1 (en) * 2022-12-16 2024-06-20 Tourmaline Bio, Inc. Methods for the treatment of noninfectious uveitis

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326859A (en) * 1979-10-30 1994-07-05 Juridical Foundation, Japanese Foundation For Cancer Research DNA and recombinant plasmid
US5554513A (en) * 1979-11-21 1996-09-10 Yeda Research & Development Co. Ltd. Production of recombinant human interferon-beta2
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US5001116A (en) * 1982-12-20 1991-03-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US5807715A (en) * 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
JP2598666B2 (ja) 1987-10-19 1997-04-09 忠三 岸本 抗ヒトｂｃｄｆモノクローナル抗体
US5210116A (en) * 1988-01-19 1993-05-11 Yazaki Corporation Resin composite material containing graphite fiber
IL88375A (en) * 1988-11-14 1995-07-31 Yeda Res & Dev Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method
CA1341588C (en) 1988-01-26 2009-01-06 Michel Revel Human ifn-beta2/i1-6, its purification and use
US6682896B1 (en) * 1988-10-14 2004-01-27 Schering Aktiengesellschaft Peptides representing epitopic sites on r-IFN-β, antibodies thereto and uses thereof
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP0399429A1 (en) 1989-05-22 1990-11-28 Toray Industries, Inc. Anti-human interleukin-6 monoclonal antibody
JP2881311B2 (ja) 1989-07-28 1999-04-12 味の素株式会社 抗ヒトｂｃｄｆモノクローナル抗体及びそれを用いたヒトｂｃｄｆの定量法
DE3939706C1 (es) 1989-12-01 1991-03-21 Centre Regional De Transfusion Sanguine, Besancon, Fr
DK0504307T3 (da) 1989-12-04 1994-03-21 Schering Corp Fremgangsmåde til behandling af septisk shock
JPH05503098A (ja) 1989-12-15 1993-05-27 カイロン　コーポレイション セプシスの処理のためのサイトカイン抗体
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5942220A (en) * 1990-03-16 1999-08-24 Chiron Corporation Inhibitor of cytokine activity and applications thereof
US5210075A (en) 1990-02-16 1993-05-11 Tanabe Seiyaku Co., Ltd. Interleukin 6 antagonist peptides
ATE181575T1 (de) * 1991-04-25 1999-07-15 Chugai Pharmaceutical Co Ltd Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptor
JPH05304986A (ja) 1992-04-28 1993-11-19 Tosoh Corp ｇｐ１３０蛋白質に対するモノクロ−ナル抗体
EP0672144A1 (en) * 1992-10-20 1995-09-20 Chiron Corporation Interleukin-6 receptor antagonists
JP3525221B2 (ja) * 1993-02-17 2004-05-10 味の素株式会社 免疫抑制剤
US5888511A (en) * 1993-02-26 1999-03-30 Advanced Biotherapy Concepts, Inc. Treatment of autoimmune diseases, including AIDS
WO1994028159A1 (fr) * 1993-05-31 1994-12-08 Chugai Seiyaku Kabushiki Kaisha Anticorps humain reconstruit contre l'interleukine-6 humaine
US5789552A (en) * 1993-06-23 1998-08-04 Istituto Di Ricerche Di Biologica Molecolare P. Angeletti S.P.A. Interleukin-6 receptor antagonists
ES2290074T3 (es) 1993-07-19 2008-02-16 Angiotech Pharmaceuticals, Inc. Composiciones anti-angiogenicas que contienen taxol y un vehiculo no biodegradable y su uso.
US5888510A (en) * 1993-07-21 1999-03-30 Chugai Seiyaku Kabushiki Kaisha Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
FR2707882B1 (fr) * 1993-07-23 1997-08-01 Immunotech Sa Nouveaux kits thérapeutiques anti-médiateurs protéiques, procédé de préparation et compositions pharmaceutiques les renfermant.
US5641657A (en) * 1994-05-19 1997-06-24 Human Genome Sciences, Inc. DNA encoding an interleukin-6 splice variant
NZ288997A (en) 1994-06-24 1999-01-28 Immunex Corp Controlled release pharmaceutical formulation comprising polypeptide encapsulated in alginate
US8017121B2 (en) * 1994-06-30 2011-09-13 Chugai Seiyaku Kabushika Kaisha Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
US5738931A (en) * 1994-09-16 1998-04-14 Kabushiki Kaisha Toshiba Electronic device and magnetic device
PT783893E (pt) 1994-10-07 2012-05-24 Chugai Pharmaceutical Co Ltd Inibição do crescimento anormal das células sinoviais usando antagonistas de il-6 como componente ativo
IT1274782B (it) * 1994-12-14 1997-07-24 Angeletti P Ist Richerche Bio Metodo per selezionare superagonisti, antagonisti e superantagonisti di ormoni del cui complesso recettoriale fa parte gp 130
US6086874A (en) 1994-12-29 2000-07-11 Chugai Seiyaku Kabushiki Kaisha Antitumor agent effect enhancer containing IL-6 antagonist
DE69636278T2 (de) * 1995-02-13 2007-05-03 Chugai Seiyaku K.K. Inhibitor des muskelproteinabbaus enthaltend einen il-6 rezeptor antikörper
IT1276555B1 (it) * 1995-04-28 1997-11-03 Angeletti P Ist Richerche Bio Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni
US5871723A (en) * 1995-06-06 1999-02-16 The Regent Of The University Of Michigan CXC chemokines as regulators of angiogenesis
US5854398A (en) * 1996-07-25 1998-12-29 The Trustees Of Columbia University In The City Of New York Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin 6 (IL-6) and uses thereof
US6461604B1 (en) * 1996-08-16 2002-10-08 Genetics Institute, Llc Crystalline IL-6 and models of the molecular structure of IL-6
AU9484798A (en) 1997-09-11 1999-03-29 Public Health Research Institute Of The City Of New York, Inc., The Enhancement of mucosal antibody responses by interleukin-6
JP4124573B2 (ja) 1998-03-17 2008-07-23 中外製薬株式会社 Ｉｌ−６アンタゴニストを有効成分として含有する炎症性腸疾患の予防又は治療剤
ES2276525T3 (es) 1998-08-24 2007-06-16 Chugai Seiyaku Kabushiki Kaisha Preventivos o remedios para la pancreatitis que contienen anticuerpos anti-receptor il-6 como ingrediente activo.
WO2001016180A2 (en) * 1999-08-27 2001-03-08 Board Of Regents, The University Of Texas System Cd40 agonist compositions and methods of use
NZ520392A (en) 2000-02-10 2005-04-29 Abbott Lab Antibodies that bind human interleukin-18 and methods of making and using
EP1314437B1 (en) * 2000-08-11 2014-06-25 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing preparations
US7320792B2 (en) * 2000-10-25 2008-01-22 Chugai Seiyaku Kabushiki Kaisha Preventives or remedies for psoriasis containing as the active ingredient IL-6 antagonist
EP1379275A4 (en) * 2001-03-14 2005-12-21 Centocor Inc IMMUNOGLOBULIN-ASSOCIATED PROTEINS ASSOCIATED WITH OBSTRUCTIVE CHRONIC BRONCHOPNEUMOPATHY, COMPOSITIONS, METHODS AND USES
DK2308888T3 (en) 2001-11-14 2017-06-06 Janssen Biotech Inc Anti-IL-6 Antibodies, Compositions, Methods and Uses
WO2003083061A2 (en) 2002-03-26 2003-10-09 Centocor, Inc. Anti-tnf antibodies, compositions, methods and uses
DE10228103A1 (de) 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
KR20050058486A (ko) * 2002-08-30 2005-06-16 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 인간형 항인간 인터루킨-6 항체 및 항체 단편
WO2004045507A2 (en) 2002-11-15 2004-06-03 Centocor, Inc. Anti-angiogenic uses of il-6 antagonists
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CA2514997A1 (en) 2003-02-04 2004-08-26 Mohit Trikha Use of il-6 antagonists in combination with steroids to enhance apoptosis
GB2401040A (en) 2003-04-28 2004-11-03 Chugai Pharmaceutical Co Ltd Method for treating interleukin-6 related diseases
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
US20050033029A1 (en) 2003-06-30 2005-02-10 Jin Lu Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
EP1673396A1 (en) 2003-09-22 2006-06-28 BioVation GmbH & Co.KG. Use of antibodies for reducing the biological effectiveness of il-6
RU2346996C2 (ru) 2004-06-29 2009-02-20 ЮРОПИЭН НИКЕЛЬ ПиЭлСи Усовершенствованное выщелачивание основных металлов
FI20050753A (fi) 2004-09-03 2006-03-04 Licentia Oy Uudet peptidit
US7973140B2 (en) 2004-12-21 2011-07-05 Medimmune Limited Antibodies directed to angiopoietin-2 and uses thereof
CN112480257A (zh) * 2005-03-23 2021-03-12 根马布股份公司 用于治疗多发性骨髓瘤的cd38抗体
PE20061324A1 (es) * 2005-04-29 2007-01-15 Centocor Inc Anticuerpos anti-il-6, composiciones, metodos y usos
KR101446510B1 (ko) 2005-12-08 2014-10-20 메다렉스, 엘.엘.시. 푸코실-지엠1에 대한 인간 모노클론 항체 및 항-푸코실-지엠1 사용법
CA2635615A1 (en) * 2005-12-30 2007-07-12 Merck Patent Gesellschaft Mit Beschraenkter Haftung Anti-il-6 antibodies preventing the binding of il-6 complexed with il-6ralpha to gp130
TW200801513A (en) 2006-06-29 2008-01-01 Fermiscan Australia Pty Ltd Improved process
CA2657763C (en) * 2006-08-03 2016-05-31 Vaccinex Inc. Anti-il-6 monoclonal antibodies and uses thereof
TW200831528A (en) * 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
US9056905B2 (en) * 2007-05-21 2015-06-16 Alderbio Holdings Llc Antibodies to TNF-α and use thereof
BRPI0811782A2 (pt) 2007-05-21 2019-02-26 Alder Biopharmaceuticals, Inc. anticorpos para il-6 e uso dos mesmos
US8188235B2 (en) 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses

Also Published As

Publication number Publication date
CN104387471A (zh) 2015-03-04
US20120202285A1 (en) 2012-08-09
TW201002348A (en) 2010-01-16
HK1155184A1 (en) 2012-05-11
IL208532A0 (en) 2010-12-30
KR20110031152A (ko) 2011-03-24
US8188235B2 (en) 2012-05-29
WO2009155180A1 (en) 2009-12-23
AU2009260320A8 (en) 2011-11-10
BRPI0914943A2 (pt) 2013-09-17
PE20140825A1 (es) 2014-07-18
AU2009260320A1 (en) 2009-12-23
SG194358A1 (en) 2013-11-29
IL232276A0 (en) 2014-06-30
ZA201006979B (en) 2012-06-27
AU2009260320B2 (en) 2014-10-30
US8846037B2 (en) 2014-09-30
PH12013502205A1 (en) 2015-10-12
RU2011101589A (ru) 2012-07-27
JP2015166366A (ja) 2015-09-24
JP2011524750A (ja) 2011-09-08
US20150203574A1 (en) 2015-07-23
US20130280266A1 (en) 2013-10-24
WO2009155180A8 (en) 2011-01-20
AR072167A1 (es) 2010-08-11
CN102083860B (zh) 2014-12-03
MX2010012272A (es) 2010-12-02
CN102083860A (zh) 2011-06-01
EP2291404A1 (en) 2011-03-09
NZ588469A (en) 2012-09-28
US8436158B2 (en) 2013-05-07
PA8830701A1 (es) 2010-04-21
US20090317402A1 (en) 2009-12-24
UY31904A (es) 2009-12-14
CA2724257A1 (en) 2009-12-23
CO6351748A2 (es) 2011-12-20

Similar Documents

Publication Publication Date Title
PE20110561A1 (es) Anticuerpos contra il-6
PE20140194A1 (es) Agentes de union a cd33
PE20110771A1 (es) Anticuerpos monoclonales contra el inhibidor de la via del factor tisular (tfpi)
PE20170687A1 (es) Proteinas de enlace a cd127
PE20110345A1 (es) Anticuerpos contra la il17 humana
UA109633C2 (uk) Антитіло людини проти тканинного фактора
EA201391761A1 (ru) Анти-альфа-синуклеинсвязывающие молекулы
PE20161327A1 (es) Proteinas de enlace al antigeno il-23 humana
PE20090329A1 (es) Anticuerpos humanizados contra el globulomero ab(20-42) y sus usos
RU2011129204A (ru) Антитела против ангиопоэтина-2 человека
PE20110668A1 (es) Anticuerpos anti-linfopoyetina estromal timica (anti-tslp)
EA201991099A1 (ru) Антитела против cd73 и их применение
UA112743C2 (uk) Терапевтичний dll4-зв'язувальний білок
RS54259B1 (en) HAVE AUTOANTITELA ACHIEVEMENTS
PE20140247A1 (es) Anticuerpos anti-cd38
PE20120079A1 (es) Moleculas de anticuerpos mejoradas
PE20142407A1 (es) Formulacion de anticuerpos
PE20131209A1 (es) Anticuerpos anti-fap
PE20142243A1 (es) Anticuerpos que se unen a ox40 y sus usos
PE20141432A1 (es) Anticuerpos neutralizantes de citomegalovirus humano
UA94452C2 (ru) Гуманизированные моноклональные антитела к фактору роста гепатоцитов
PE20110385A1 (es) Anticuerpo de dominio (dab) que se une a cd28 y no reacciona en forma cruzada con ctla4
PE20120415A1 (es) Anticuerpos anti-igf
PE20090689A1 (es) Anticuerpos del antagonista ox40 y su uso en el tratamiento de enfermedades inflamatorias y autoinmunes
MX348577B (es) Composicion farmaceutica para el tratamiento y/o prevencion de cancer.

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed