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PE20091092A1 - Compuestos heterociclicos como inhibidores de la via hedgehog - Google Patents

Compuestos heterociclicos como inhibidores de la via hedgehog

Info

Publication number
PE20091092A1
PE20091092A1 PE2008001563A PE2008001563A PE20091092A1 PE 20091092 A1 PE20091092 A1 PE 20091092A1 PE 2008001563 A PE2008001563 A PE 2008001563A PE 2008001563 A PE2008001563 A PE 2008001563A PE 20091092 A1 PE20091092 A1 PE 20091092A1
Authority
PE
Peru
Prior art keywords
methyl
inhibitors
carboxamide
pyridin
trifluoromethyl
Prior art date
Application number
PE2008001563A
Other languages
English (en)
Inventor
Benjamin Fauber
Alexander Hird
James Janetka
Daniel John Russell
Bin Yang
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20091092A1 publication Critical patent/PE20091092A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO HETEROCICLICO DE FORMULA (I), DONDE R1, R2 Y R3 SON H, HALOGENO O ALQUILO C1-C6; R4 ES HALOGENO, ALQUILO C1-C6 O HALOALQUILO C1-C6; W ES N, O, S, CR5, ENTRE OTROS; R5 ES H, ALCOXILO C1-C6, ALQUILO C1-C6, ENTRE OTROS; A ES N, CR6, NR6, N, O, S; R6 ES H, ALCOXILO C1-C6, AMINO, AMIDO, ENTRE OTROS; q Y p SON 0 O 1. SON COMPUESTOS PREFERIDOS: N-[4-CLORO-3-(1,5-DIMETIL-1H-IMIDAZOL-2-IL)FENIL]-2-METIL-6-(TRIFLUOROMETIL)PIRIDIN-3-CARBOXAMIDA, N-[4-CLORO-3-(1-METIL-1H-IMIDAZOL-2-IL)FENIL]-2-METIL-6-(TRIFLUOROMETIL)PIRIDIN-3-CARBOXAMIDA, N-[3-(5-AMINOPIRAZIN-2-IL)-4-CLOROFENIL]-2-METIL-6-(TRIFLUOROMETIL)PIRIDIN-3-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA VIA HEDGEHOG Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS CELULARES
PE2008001563A 2007-09-05 2008-09-05 Compuestos heterociclicos como inhibidores de la via hedgehog PE20091092A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97010707P 2007-09-05 2007-09-05
US3666108P 2008-03-14 2008-03-14

Publications (1)

Publication Number Publication Date
PE20091092A1 true PE20091092A1 (es) 2009-08-27

Family

ID=39938463

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001563A PE20091092A1 (es) 2007-09-05 2008-09-05 Compuestos heterociclicos como inhibidores de la via hedgehog

Country Status (5)

Country Link
AR (1) AR068376A1 (es)
PE (1) PE20091092A1 (es)
TW (1) TW200916458A (es)
UY (1) UY31322A1 (es)
WO (1) WO2009030952A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012529530A (ja) * 2009-06-09 2012-11-22 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー ヘッジホッグシグナル伝達の阻害剤としての、イソキノリン、キノリン及びキナゾリン誘導体
MX2012007929A (es) 2010-01-07 2012-11-21 Selexagen Therapeutics Inc Inhibidores erizo.
WO2011095807A1 (en) * 2010-02-07 2011-08-11 Astrazeneca Ab Combinations of mek and hh inhibitors
CN101993415B (zh) * 2010-09-15 2013-08-14 北京韩美药品有限公司 作为Hedgehog通路抑制剂的化合物以及包含该化合物的药物组合物及其应用
CN103570625A (zh) 2012-07-19 2014-02-12 南京英派药业有限公司 N-(3-杂芳基芳基)-4-芳基芳基甲酰胺和类似物作为Hedgehog通路抑制剂及其应用
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
KR102341660B1 (ko) 2016-09-19 2021-12-23 노파르티스 아게 Raf 억제제 및 erk 억제제를 포함하는 치료적 조합
WO2018082587A1 (zh) * 2016-11-04 2018-05-11 上海瑛派药业有限公司 Hedgehog通路抑制剂在治疗纤维化疾病中的应用
ES2952265T3 (es) 2017-05-02 2023-10-30 Novartis Ag Terapia combinada que comprende un inhibidor de Raf y trametinib
CN107281214A (zh) * 2017-06-06 2017-10-24 北京工业大学 氢分子液体/气体在制备抑制肿瘤干细胞药物中的应用
CN109369634B (zh) * 2018-12-19 2021-07-27 陕西国际商贸学院 具有抗肿瘤活性的2-甲氧基烟酰胺衍生物制备方法及用途
AU2022295990A1 (en) 2021-06-18 2024-01-04 Aligos Therapeutics, Inc. Methods and compositions for targeting pd-l1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2295553T3 (es) * 2002-02-12 2008-04-16 Smithkline Beecham Corporation Derivados de nicotinamida utiles como inhibidores de p38.
DE60322869D1 (de) * 2002-04-22 2008-09-25 Univ Johns Hopkins Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen
KR20070005736A (ko) * 2004-04-30 2007-01-10 제넨테크, 인크. 헤지호그 신호전달 경로의 퀴녹살린 억제제
PT1789390E (pt) * 2004-09-02 2012-02-08 Genentech Inc Inibidores de piridilo da sinalização de hedgehog
US7816369B2 (en) * 2004-11-03 2010-10-19 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
US20090258917A1 (en) * 2005-10-12 2009-10-15 Benjamin Pelcman Benzoxazoles Useful in the Treatment of Inflammation
PE20080948A1 (es) * 2006-07-25 2008-09-10 Irm Llc Derivados de imidazol como moduladores de la senda de hedgehog

Also Published As

Publication number Publication date
TW200916458A (en) 2009-04-16
AR068376A1 (es) 2009-11-11
WO2009030952A3 (en) 2009-05-07
UY31322A1 (es) 2009-04-30
WO2009030952A2 (en) 2009-03-12

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