PE20091068A1 - Compuestos pirrolo[3,2-d]pirimidina y su uso como inhibidores de quinasa pi3 y quinasa mtor - Google Patents
Compuestos pirrolo[3,2-d]pirimidina y su uso como inhibidores de quinasa pi3 y quinasa mtorInfo
- Publication number
- PE20091068A1 PE20091068A1 PE2008001969A PE2008001969A PE20091068A1 PE 20091068 A1 PE20091068 A1 PE 20091068A1 PE 2008001969 A PE2008001969 A PE 2008001969A PE 2008001969 A PE2008001969 A PE 2008001969A PE 20091068 A1 PE20091068 A1 PE 20091068A1
- Authority
- PE
- Peru
- Prior art keywords
- kinase
- pirrolo
- substituted
- alkyl
- mtor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A UN COMPUESTO DE FORMULA I, DONDE R1 ES ALQUILO C1-C6 SUSTITUIDO O NO, ALQUENILO C2-C6 SUSTITUIDO NO NO, ARILO C6-C14, ENTRE OTROS; A ES -O-, CH2O-, -S-, -S(O)-, S(O)2-; m ES 0-2; R2 ES HALOGENO, ALQUILO C1-C6 SUSTITUIDO O NO, ALCOXI C1-C6 SUSTITUIDO O NO, ALQUENILO C2-C6, ENTRE OTROS; n ES 1-5; R3 Y R4 SON CADA UNO H, ALQUILO C1-C6 SUSTITUIDO O NO, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS; R5 ES DE PREFERENCIA H. SON COMPUESTOS PREFERIDOS: 2-[3-(BENCILOXI)FENIL]-4-MORFOLIN-4-IL5H-PIRROLO[3,2-d]PIRIMIDINA; {3-[4-MORFOLIN-4-IL-7-(PIRROLIDIN-1-ILMETIL)-5H-PIRROLO[3,2-d]PIRIMIDIN-2-IL]FENIL}METANOL; {3-[7-(1-BENCIL-1,2,3,6-TETRAHIDROPIRIDIN-4-IL)-4-MORFOLIN-4-IL-5H-PIRROLO[3,2-d]PIRIMIDIN-2-IL]FENIL}METANOL; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES PI3K Y mTOR UTILES COMO AGENTES CARCINOSTATICOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99042407P | 2007-11-27 | 2007-11-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091068A1 true PE20091068A1 (es) | 2009-07-15 |
Family
ID=40548516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001969A PE20091068A1 (es) | 2007-11-27 | 2008-11-25 | Compuestos pirrolo[3,2-d]pirimidina y su uso como inhibidores de quinasa pi3 y quinasa mtor |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090149458A1 (es) |
| CL (1) | CL2008003506A1 (es) |
| PE (1) | PE20091068A1 (es) |
| TW (1) | TW200930374A (es) |
| WO (1) | WO2009070524A1 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE456836T1 (de) * | 1996-09-04 | 2010-02-15 | Intertrust Tech Corp | Zuverlässige infrastrukturhilfssysteme, verfahren und techniken für sicheren elektronischen handel, elektronische transaktionen, handelsablaufsteuerung und automatisierung, verteilte verarbeitung und rechteverwaltung |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| JP5740076B2 (ja) | 2005-07-25 | 2015-06-24 | エマージェント・プロダクト・ディベロップメント・シアトル・エルエルシー | Ｃｄ３７特異的及びｃｄ２０特異的結合分子を用いたｂ細胞の減少 |
| NZ612319A (en) | 2006-06-12 | 2015-04-24 | Emergent Product Dev Seattle | Single-chain multivalent binding proteins with effector function |
| JP5520831B2 (ja) | 2007-12-19 | 2014-06-11 | アムジエン・インコーポレーテツド | Ｐｉ３キナーゼの阻害薬 |
| WO2009098236A1 (en) | 2008-02-06 | 2009-08-13 | Novartis Ag | Pyrrolo [2, 3-d] pyridines and use thereof as tyrosine kinase inhibitors |
| MX2010011057A (es) | 2008-04-11 | 2010-11-12 | Trubion Pharmaceuticals Inc | Inmunoterapeutico de cd37 y combinacion con quimioterapeutico bifuncional del mismo. |
| UA101676C2 (uk) * | 2008-07-31 | 2013-04-25 | Дженентек, Инк. | Піримідинові сполуки, композиції і способи застосування |
| TWI378933B (en) | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
| SG176959A1 (en) * | 2009-06-24 | 2012-01-30 | Genentech Inc | Oxo-heterocycle fused pyrimidine compounds, compositions and methods of use |
| MX2012000817A (es) | 2009-07-21 | 2012-05-08 | Gilead Calistoga Llc | Tratamiento para desordenes del higado con inhibidores pi3k. |
| WO2011025889A1 (en) * | 2009-08-28 | 2011-03-03 | Takeda Pharmaceutical Company Limited | HEXAHYDROOXAZINOPTERINE COMPOUNDS FOR USE AS mTOR INHIBITORS |
| KR101469334B1 (ko) | 2009-11-12 | 2014-12-04 | 에프. 호프만-라 로슈 아게 | Ｎ-9-치환된 퓨린 화합물, 조성물 및 사용 방법 |
| RU2515541C2 (ru) * | 2009-11-12 | 2014-05-10 | Ф.Хоффманн-Ля Рош Аг | N-7 замещенные пурины и пиразолопиримидины, их композиции и способы применения |
| EP3399026B1 (en) | 2010-06-14 | 2024-06-26 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| TW201204733A (en) | 2010-06-25 | 2012-02-01 | Kowa Co | Novel condensed pyridine or condensed pyrimidine derivative, and medicinal agent comprising same |
| CA2829558A1 (en) * | 2011-03-09 | 2012-09-13 | Celgene Avilomics Research, Inc. | Pi3 kinase inhibitors and uses thereof |
| KR20160027217A (ko) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법 |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| MX2016014878A (es) | 2014-05-14 | 2017-03-08 | Pfizer | Pirazolopiridinas y pirazolopirimidinas. |
| CN108367004B (zh) | 2015-09-21 | 2022-09-13 | 阿帕特夫研究和发展有限公司 | Cd3结合多肽 |
| CN109384782A (zh) * | 2017-08-04 | 2019-02-26 | 厦门大学 | 取代五元并六元杂环类化合物、其制备方法、药物组合及其用途 |
| CN112707907B (zh) * | 2019-10-24 | 2023-05-23 | 张飞 | 嘌呤衍生物及其中间体与制备抗癌症药物的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3649395B2 (ja) * | 2000-04-27 | 2005-05-18 | 山之内製薬株式会社 | 縮合ヘテロアリール誘導体 |
-
2008
- 2008-11-24 WO PCT/US2008/084498 patent/WO2009070524A1/en active Application Filing
- 2008-11-24 US US12/276,459 patent/US20090149458A1/en not_active Abandoned
- 2008-11-25 PE PE2008001969A patent/PE20091068A1/es not_active Application Discontinuation
- 2008-11-25 CL CL2008003506A patent/CL2008003506A1/es unknown
- 2008-11-27 TW TW097146014A patent/TW200930374A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009070524A1 (en) | 2009-06-04 |
| CL2008003506A1 (es) | 2009-01-09 |
| TW200930374A (en) | 2009-07-16 |
| US20090149458A1 (en) | 2009-06-11 |
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Legal Events
| Date | Code | Title | Description |
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| FX | Voluntary withdrawal |