PE20001227A1 - PROCESSES TO PRODUCE AN ISOTRETINOIN COMPOSITION - Google Patents
PROCESSES TO PRODUCE AN ISOTRETINOIN COMPOSITIONInfo
- Publication number
- PE20001227A1 PE20001227A1 PE1999001072A PE00107299A PE20001227A1 PE 20001227 A1 PE20001227 A1 PE 20001227A1 PE 1999001072 A PE1999001072 A PE 1999001072A PE 00107299 A PE00107299 A PE 00107299A PE 20001227 A1 PE20001227 A1 PE 20001227A1
- Authority
- PE
- Peru
- Prior art keywords
- isotretinoin
- produce
- size
- processes
- vehicle
- Prior art date
Links
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 title abstract 5
- 229960005280 isotretinoin Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000003981 vehicle Substances 0.000 abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 2
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- -1 PROPYLENE GLYCOL TRIESTER Chemical class 0.000 abstract 1
- 235000019483 Peanut oil Nutrition 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 238000000265 homogenisation Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 235000008390 olive oil Nutrition 0.000 abstract 1
- 239000004006 olive oil Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000312 peanut oil Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN PROCESO PARA LA ELABORACION DE UNA COMPOSICION DE ISOTRETINOINA MICRONIZADA DE TAMANO DE PARTICULA DE 5µm A 20µm SUSPENDIDA EN UN VEHICULO OLEOSO QUE COMPRENDE a)DISPERSAR ISOTRETINOINA CON TAMANO DE PATICULA SUPERIOR A 20 µm EN EL VEHICULO OLEOSO PARA FORMAR UNA SUSPENSION QUE CONTIENE 1% A 70% EN PESO DE ISOTRETINOINA; b)SOMETER DICHA SUSPENSION A MEDIOS MECANICOS COMO LA MOLTURACION HUMEDA, HOMOGENIZACION POR ELEVADA CIZALLADURA, MICRONIZACION POR PROPULSION LIQUIDA QUE PRODUCEN CIZALLADURA, IMPACTO, CAVITACION O FRICCION, PARA REDUCIR EL TAMANO DE PARTICULA DE LA ISOTRETINOINA; EL VEHICULO OLEOSO PUEDE SER ACEITE DE SEMILLA DE SOJA, ACEITE DE CACAHUATE, ACEITE DE OLIVA, TRIGLICERIDO DE ACIDO GRASO C6-C18, POLIETILENGLICOL, TRIESTER DE PROPILENGLICOL. LA ISOTRETINOINA SE UTILIZA PARA EL TRATAMIENTO DE ACNE CISTICOIT REFERS TO A PROCESS FOR THE ELABORATION OF A MICRONIZED ISOTRETINOIN COMPOSITION OF A PARTICLE SIZE FROM 5µm TO 20µm SUSPENDED IN AN OILY VEHICLE, INCLUDING a) DISPERSING ISOTRETINOIN WITH A SIZE OF PATICULA OR FORMING IN THE VEHICLE GREATER THAN 20 µm CONTAINS 1% TO 70% BY WEIGHT OF ISOTRETINOIN; b) SUBMIT SUCH SUSPENSION TO MECHANICAL MEANS SUCH AS WET MOLTURATION, HOMOGENIZATION BY HIGH SHEAR, MICRONIZATION BY LIQUID PROPULSION THAT PRODUCE SHEAR, IMPACT, CAVITATION OR FRICTION, TO REDUCE THE ISOLATION OF PARTICULAR SIZE; THE OILY VEHICLE MAY BE SOYBEAN SEED OIL, PEANUT OIL, OLIVE OIL, C6-C18 FATTY ACID TRIGLYCERIDE, POLYETHYLENE GLYCOL, PROPYLENE GLYCOL TRIESTER. ISOTRETINOIN IS USED FOR THE TREATMENT OF CYSTAL ACNE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10633198P | 1998-10-30 | 1998-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001227A1 true PE20001227A1 (en) | 2000-11-06 |
Family
ID=22310843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999001072A PE20001227A1 (en) | 1998-10-30 | 1999-10-26 | PROCESSES TO PRODUCE AN ISOTRETINOIN COMPOSITION |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1131068A1 (en) |
| JP (1) | JP2002528492A (en) |
| KR (1) | KR20010073226A (en) |
| CN (1) | CN1324235A (en) |
| AR (1) | AR020999A1 (en) |
| AU (1) | AU1044400A (en) |
| BR (1) | BR9914932A (en) |
| CA (1) | CA2347098A1 (en) |
| NO (1) | NO20012014D0 (en) |
| PE (1) | PE20001227A1 (en) |
| TR (1) | TR200101156T2 (en) |
| WO (1) | WO2000025772A1 (en) |
| ZA (1) | ZA200102731B (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7374779B2 (en) | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
| DE19932157A1 (en) | 1999-07-13 | 2001-01-18 | Pharmasol Gmbh | Process for the gentle production of ultra-fine microparticles and nanoparticles |
| FR2807662A1 (en) * | 2000-04-12 | 2001-10-19 | Cll Pharma | PROCESS FOR STABILIZING THE SIZE OF AN ACTIVE INGREDIENT DISPERSE IN A LIQUID AND ITS APPLICATIONS |
| IN192188B (en) * | 2000-06-16 | 2004-03-13 | Ranbaxy Lab Ltd | |
| EP1318791B1 (en) | 2000-09-22 | 2004-07-07 | Galephar M/F | Pharmaceutical semi-solid composition of isotretinoin |
| EA200400782A1 (en) * | 2001-12-06 | 2005-08-25 | Рэнбакси Лабораториз Лимитед | COMPOSITION OF ISOTRETINOININ WITH CRUSHING COMPONENTS UNDER THE DEGREE OF NANOPARTICLES |
| EP1527774A1 (en) | 2003-11-03 | 2005-05-04 | Basilea Pharmaceutica AG | New formulation for retinoid-containing soft gelatin capsules |
| SE0303135D0 (en) * | 2003-11-25 | 2003-11-25 | Lipocore Holding Ab | Controlled food effect composition |
| CZ300424B6 (en) * | 2006-06-20 | 2009-05-13 | Pliva - Lachema A. S. | Pharmaceutical composition for peroral administration |
| KR101434706B1 (en) * | 2007-02-16 | 2014-08-26 | 아스카 세이야쿠 가부시키가이샤 | Pharmaceutical composition containing fine particle oil-based suspension |
| US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
| WO2010109259A1 (en) * | 2009-03-26 | 2010-09-30 | Grufarcol Ltda | Method for preparing soft gel formulations of liquid isotretinoin and formulations obtained |
| US10022348B2 (en) | 2009-05-20 | 2018-07-17 | Sun Pharmaceutical Industries Limited | Topical solution of isotretinoin |
| CA2762391C (en) | 2009-05-20 | 2017-02-07 | Ranbaxy Laboratories Limited | Liquid dosage forms of isotretinoin |
| EP2432453A2 (en) | 2009-05-20 | 2012-03-28 | Ranbaxy Laboratories Limited | Topical retinoid solutions |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
| US9078925B2 (en) | 2012-06-18 | 2015-07-14 | Galephar Pharmaceutical Research, Inc. | Pharmaceutical semi-solid composition of isotretinoin |
| JP6018845B2 (en) * | 2012-09-03 | 2016-11-02 | 三生医薬株式会社 | Method for producing capsule containing ultrafine powder |
| MA40312A (en) | 2014-05-29 | 2017-04-05 | Sun Pharmaceutical Ind Ltd | Oral pharmaceutical composition of isotretinoin |
| CA2950533A1 (en) * | 2014-06-02 | 2015-12-10 | Sun Pharmaceutical Industries Limited | Oral pharmaceutical composition of isotretinoin |
| CA2956831A1 (en) | 2014-07-31 | 2016-02-04 | Sun Pharmaceutical Industries Limited | Oral pharmaceutical composition of isotretinoin |
| US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
| US20170246187A1 (en) | 2014-08-28 | 2017-08-31 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
| MA40781A (en) * | 2014-10-01 | 2017-08-08 | Sun Pharmaceutical Ind Ltd | PHARMACEUTICAL COMPOSITION OF LOW DOSAGE ISOTRETINOIN FOR ORAL USE |
| US9750711B2 (en) * | 2014-10-01 | 2017-09-05 | Sun Pharmaceutical Industries Limited | Low dose oral pharmaceutical composition of isotretinoin |
| MX2017015137A (en) * | 2015-05-25 | 2018-03-28 | Sun Pharmaceutical Ind Ltd | Once daily oral pharmaceutical composition of isotretinoin. |
| WO2017203365A1 (en) | 2016-05-26 | 2017-11-30 | Dr. Reddy's Laboratiories Ltd. | Pharmaceutical compositions for treating acne |
| WO2018098501A1 (en) | 2016-11-28 | 2018-05-31 | Lipocine Inc. | Oral testosterone undecanoate therapy |
| US12016830B2 (en) | 2022-07-01 | 2024-06-25 | Acrotech Biopharma, LLC | Pharmaceutical compositions comprising isotretinoin and processes for preparation and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2557615C2 (en) * | 1975-12-20 | 1985-08-14 | Bayer Ag, 5090 Leverkusen | New niclosamide suspension formulations |
| DE3119383A1 (en) * | 1981-05-15 | 1982-12-02 | Basf Ag, 6700 Ludwigshafen | METHOD FOR PRODUCING FINE DISTRIBUTED, POWDERED CAROTINO PREPARATIONS |
| CA1282326C (en) * | 1984-12-14 | 1991-04-02 | Paul J. Jarosz | Pharmaceutical composition containing 13-cis vitamin a acid as the active ingredient |
-
1999
- 1999-10-26 PE PE1999001072A patent/PE20001227A1/en not_active Application Discontinuation
- 1999-10-28 AR ARP990105436A patent/AR020999A1/en unknown
- 1999-10-29 AU AU10444/00A patent/AU1044400A/en not_active Abandoned
- 1999-10-29 KR KR1020017005426A patent/KR20010073226A/en not_active Application Discontinuation
- 1999-10-29 BR BR9914932-0A patent/BR9914932A/en not_active Application Discontinuation
- 1999-10-29 JP JP2000579213A patent/JP2002528492A/en active Pending
- 1999-10-29 WO PCT/EP1999/008208 patent/WO2000025772A1/en not_active Application Discontinuation
- 1999-10-29 EP EP99953954A patent/EP1131068A1/en not_active Withdrawn
- 1999-10-29 CA CA002347098A patent/CA2347098A1/en not_active Abandoned
- 1999-10-29 CN CN99812404A patent/CN1324235A/en active Pending
- 1999-10-29 TR TR2001/01156T patent/TR200101156T2/en unknown
-
2001
- 2001-04-03 ZA ZA200102731A patent/ZA200102731B/en unknown
- 2001-04-24 NO NO20012014A patent/NO20012014D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1131068A1 (en) | 2001-09-12 |
| KR20010073226A (en) | 2001-07-31 |
| AR020999A1 (en) | 2002-06-05 |
| NO20012014L (en) | 2001-04-24 |
| JP2002528492A (en) | 2002-09-03 |
| AU1044400A (en) | 2000-05-22 |
| CA2347098A1 (en) | 2000-05-11 |
| NO20012014D0 (en) | 2001-04-24 |
| BR9914932A (en) | 2001-07-10 |
| WO2000025772A1 (en) | 2000-05-11 |
| TR200101156T2 (en) | 2001-08-21 |
| CN1324235A (en) | 2001-11-28 |
| ZA200102731B (en) | 2002-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |