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PA8606201A1 - DERIVADOS DE PIRROLO[3,4-c) PIRAZOL ACTIVOS COMO INHIBIDORES DE QUINASA, PROCESO PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN - Google Patents

DERIVADOS DE PIRROLO[3,4-c) PIRAZOL ACTIVOS COMO INHIBIDORES DE QUINASA, PROCESO PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN

Info

Publication number
PA8606201A1
PA8606201A1 PA20048606201A PA8606201A PA8606201A1 PA 8606201 A1 PA8606201 A1 PA 8606201A1 PA 20048606201 A PA20048606201 A PA 20048606201A PA 8606201 A PA8606201 A PA 8606201A PA 8606201 A1 PA8606201 A1 PA 8606201A1
Authority
PA
Panama
Prior art keywords
preparation
pirazol
pharmaceutical compositions
pirrolo
assets
Prior art date
Application number
PA20048606201A
Other languages
English (en)
Inventor
Daniele Fancelli
Barbara Forte
Jurgen Moll
Mario Varasi
Paolo Vianello
Original Assignee
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa
Publication of PA8606201A1 publication Critical patent/PA8606201A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DERIVADOS DE PIRROLO [3,4-c]PIRAZOL ACTIVOS COMO INHIBIDORES DE QUINASA, PROCESO PARA SU PREPARACION Y COMPOSICIONES FAMACEUTICAS QUE LOS COMPRENDEN SE DESCRIBEN DERIVADOS DE PIRROLO [3,4.c] PIRAZOL DE FORMULA (1) Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, COMO SE DEFINE EN LA MEMORIA DESCRIPTIVA, PROCESO PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN; LOS COMPUESTOS DE LA INVENCION PUEDEN SER UTILES, EN LA TERAPIA, EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON UNA ACTIVIDAD DESREGULADA DE LA PROTEINQUINASA, COMO EL CANCER.
PA20048606201A 2003-07-09 2004-07-09 DERIVADOS DE PIRROLO[3,4-c) PIRAZOL ACTIVOS COMO INHIBIDORES DE QUINASA, PROCESO PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN PA8606201A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48581403P 2003-07-09 2003-07-09

Publications (1)

Publication Number Publication Date
PA8606201A1 true PA8606201A1 (es) 2005-08-04

Family

ID=34062099

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20048606201A PA8606201A1 (es) 2003-07-09 2004-07-09 DERIVADOS DE PIRROLO[3,4-c) PIRAZOL ACTIVOS COMO INHIBIDORES DE QUINASA, PROCESO PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN

Country Status (42)

Country Link
US (2) US7141568B2 (es)
EP (1) EP1644376B1 (es)
JP (1) JP4728232B2 (es)
KR (1) KR101075711B1 (es)
CN (1) CN100564380C (es)
AP (1) AP2214A (es)
AR (1) AR050045A1 (es)
AT (1) ATE480540T1 (es)
AU (1) AU2004255347B2 (es)
BR (1) BRPI0411868B8 (es)
CA (1) CA2531759C (es)
CR (1) CR8171A (es)
CY (1) CY1110832T1 (es)
DE (1) DE602004029045D1 (es)
DK (1) DK1644376T3 (es)
DO (1) DOP2004000949A (es)
EA (1) EA009462B1 (es)
EC (1) ECSP056246A (es)
ES (1) ES2349780T3 (es)
GE (1) GEP20084395B (es)
GT (2) GT200400133AA (es)
HK (1) HK1089769A1 (es)
HN (1) HN2004000232A (es)
IL (1) IL172923A (es)
IS (1) IS2843B (es)
MA (1) MA28064A1 (es)
ME (1) MEP51908A (es)
MX (1) MXPA06000362A (es)
MY (1) MY139072A (es)
NO (1) NO332361B1 (es)
NZ (1) NZ544514A (es)
PA (1) PA8606201A1 (es)
PE (1) PE20050325A1 (es)
PL (1) PL1644376T3 (es)
PT (1) PT1644376E (es)
RS (2) RS52155B (es)
SI (1) SI1644376T1 (es)
TN (1) TNSN06009A1 (es)
TW (1) TWI343382B (es)
UA (1) UA81682C2 (es)
WO (1) WO2005005427A1 (es)
ZA (1) ZA200600095B (es)

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JP2007533753A (ja) * 2004-04-23 2007-11-22 タケダ サン ディエゴ インコーポレイテッド インドール誘導体及びキナーゼ阻害剤としてのその使用
WO2006023931A2 (en) * 2004-08-18 2006-03-02 Takeda San Diego, Inc. Kinase inhibitors
ATE479687T1 (de) 2004-10-15 2010-09-15 Takeda Pharmaceutical Kinaseinhibitoren
JP4250195B2 (ja) 2005-01-10 2009-04-08 ファイザー・インク ピロロピラゾール類、強力なキナーゼ阻害剤
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
TW200808311A (en) 2006-03-30 2008-02-16 Nerviano Medical Sciences Srl Use of a kinase inhibitor for the treatment of particular resistant tumors
WO2008017465A1 (en) * 2006-08-10 2008-02-14 F. Hoffmann-La Roche Ag Bicyclic lactam derivatives, their manufacture and use as pharmaceutical agents
MX2009003793A (es) 2006-10-09 2009-12-14 Takeda Pharmaceutical Inhibidores de cinasa.
JP2010505961A (ja) * 2006-10-09 2010-02-25 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
JP5547487B2 (ja) * 2006-11-03 2014-07-16 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 抗癌化合物の投与方法
CL2009001158A1 (es) * 2008-05-15 2009-10-23 Nerviano Medical Sciences Srl Compuestos derivados de los acidos carboxilicos, tales como 5,6-dihiro-4h-pirrolo[3,4-c]pirazol, furo[3,2-c]pirazol, tieno[2,3-c]pirazol, 4,5,6,7-tetrahidropirazol[4,3-c]piridina e indazol; composicion farmaceutica; y su uso en el tratamiento de trastornos proliferativos celulares asociados a la actividad de proteina quinasa alterada, tal como el cancer.
EP2313097B1 (en) * 2008-07-24 2013-03-27 Nerviano Medical Sciences S.r.l. Therapeutic combination comprising an aurora kinase inhibitor and antiproliferative agents
US20100022553A1 (en) * 2008-07-24 2010-01-28 Nerviano Medical Sciences S.R.L. Therapeutic Combination Comprising an Aurora Kinase Inhibitor and Imatinib
EP2344156B1 (en) * 2008-07-24 2018-10-17 Nerviano Medical Sciences S.r.l. Therapeutic combination comprising an aurora kinase inhibitor and an antineoplastic agent
RU2535032C2 (ru) 2008-12-22 2014-12-10 Милленниум Фармасьютикалз, Инк. Сочетание ингибиторов аврора киназы и анти-cd 20 антител
KR101849143B1 (ko) 2011-12-12 2018-04-16 닥터 레디스 레보러터리즈 리미티드 트로포미오신 수용체 키나제(Trk) 억제제인 치환된 피라졸로[1,5-a]피리딘
CN104072498B (zh) * 2013-03-26 2016-12-28 沈阳药科大学 (R)‑N‑[5‑(2‑甲氧基‑2‑苯基乙酰基)‑1,4,5,6‑四氢吡咯并[3,4‑c]吡唑‑3‑基]‑4‑(4‑甲基哌嗪‑1‑基)苯甲酰胺的合成方法
US10335494B2 (en) 2013-12-06 2019-07-02 Millennium Pharmaceuticals, Inc. Combination of aurora kinase inhibitors and anti-CD30 antibodies
EP3157921A1 (en) 2014-06-23 2017-04-26 Dr. Reddy's Laboratories Ltd. Substituted imidazo[1,2-a]pyridine compounds useful for the treatment of pain
MX2017016030A (es) * 2015-06-15 2018-08-01 Ube Industries Derivado de dihidropirrolopirazol sustituido.
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. オーロラキナーゼインヒビターと化学療法剤の投与
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Also Published As

Publication number Publication date
CA2531759C (en) 2013-04-02
US7582628B2 (en) 2009-09-01
NO20060113L (no) 2006-04-05
JP2009513525A (ja) 2009-04-02
AU2004255347A1 (en) 2005-01-20
EA200600209A1 (ru) 2006-06-30
KR20060033001A (ko) 2006-04-18
IL172923A0 (en) 2006-06-11
AU2004255347B2 (en) 2010-04-08
CR8171A (es) 2006-08-09
BRPI0411868B1 (pt) 2019-11-12
US20060276471A1 (en) 2006-12-07
JP4728232B2 (ja) 2011-07-20
HN2004000232A (es) 2011-01-17
AP2214A (en) 2011-03-04
MXPA06000362A (es) 2006-03-28
AP2006003480A0 (en) 2006-02-28
IS8192A (is) 2005-12-22
SI1644376T1 (sl) 2010-11-30
AR050045A1 (es) 2006-09-27
PT1644376E (pt) 2010-09-24
CN100564380C (zh) 2009-12-02
BRPI0411868B8 (pt) 2021-05-25
ECSP056246A (es) 2006-04-19
UA81682C2 (en) 2008-01-25
GEP20084395B (en) 2008-06-10
DK1644376T3 (da) 2011-01-03
PL1644376T3 (pl) 2011-03-31
TW200510385A (en) 2005-03-16
ZA200600095B (en) 2007-01-31
MEP51908A (en) 2011-05-10
HK1089769A1 (en) 2006-12-08
EP1644376A1 (en) 2006-04-12
EA009462B1 (ru) 2007-12-28
MY139072A (en) 2009-08-28
RS20060004A (en) 2008-06-05
CA2531759A1 (en) 2005-01-20
TWI343382B (en) 2011-06-11
EP1644376B1 (en) 2010-09-08
PE20050325A1 (es) 2005-05-17
US7141568B2 (en) 2006-11-28
CY1110832T1 (el) 2015-06-10
GT200400133AA (es) 2007-07-10
NZ544514A (en) 2009-07-31
ATE480540T1 (de) 2010-09-15
NO332361B1 (no) 2012-09-03
DOP2004000949A (es) 2005-01-15
ES2349780T3 (es) 2011-01-11
GT200400133A (es) 2005-04-18
DE602004029045D1 (de) 2010-10-21
US20050032839A1 (en) 2005-02-10
BRPI0411868A (pt) 2006-08-08
KR101075711B1 (ko) 2011-10-21
CN1820009A (zh) 2006-08-16
IL172923A (en) 2011-09-27
TNSN06009A1 (fr) 2007-10-03
MA28064A1 (fr) 2006-08-01
WO2005005427A1 (en) 2005-01-20
RS52155B (en) 2012-08-31
IS2843B (is) 2013-08-15

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