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KR900018058A - 아자사이클릭 카복실산 유도체, 이의 제조방법 및 용도 - Google Patents

아자사이클릭 카복실산 유도체, 이의 제조방법 및 용도 Download PDF

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Publication number
KR900018058A
KR900018058A KR1019890006609A KR890006609A KR900018058A KR 900018058 A KR900018058 A KR 900018058A KR 1019890006609 A KR1019890006609 A KR 1019890006609A KR 890006609 A KR890006609 A KR 890006609A KR 900018058 A KR900018058 A KR 900018058A
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South Korea
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hydroxy
hydrogen
compound
alkoxy
group
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KR1019890006609A
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제이콥 스트레이 크누센 라르스
에릭 안데르센 크누드
스틴 요르겐센 앵커
손네왈드 우르술라
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클라우스 브래스트럽
노보 인더스트리 에이/에스
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Publication of KR900018058A publication Critical patent/KR900018058A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

아자사이클릭 카복실산 유도체, 이의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 일반식(Ⅰ)의O-치환된 옥심 또는 약제학적으로 허용되는 이의 산부가염, 및 (하기 일반식(Ⅰ)에서 R1가 하이드로시인 경우) 이의 금속염 및 임의로 치환된 암모늄 염.
    상기식에서, A는또는(여기서, R1및 R2는 독립적으로 푸라닐, 이미다졸릴, 옥사졸릴, 페닐, 피라졸릴, 피라지닐, 피리다지닐, 피리디닐, 피리미디닐, 피롤릴, 티아졸린, 티에닐 및 1,2,4-트리아졸릴로 이루어진 그룹중에서 선택된 방향족 잔기를 나타내고, 각 환은 저급 알킬아미노, 저급 알킬티오, 저급 알콕시, 아미노,아지도, 시아노, 할로겐, 하이드록시, 저급 알킬, 니트로, 머캅토 및 트리플루오로메틸로 이루어진 그룹중에서 선택된 1,2 또는 3개의 치환체에 의해 임의로 치환된다)이고;R.3은 수소 또는 저급 알킬을 나타내며;n 및 m은 0 내지 2이고;R4은 일반식(Ⅱ), (Ⅲ) 또는 (Ⅳ)의 사이클릭 아미노산 잔기를 나타낸다.
    [여기에서, P는 1또는 2이고;R5는 수소 또는 하이드록시를 나타내고;R6는 수소를 나타내거나, R5는 R6과 함께 추가의 결합을 나타내고;R7은 수소 또는 저급 알킬을 나타내며;R8은 수소 또는 하이드록시를 나타내고;X는 NH2또는 R9(여기에서, R9은 하이드록시 또는 알콕시를 나타낸다)를 나타낸다].
  2. 제1항에 있어서, R1및 R2는 독립적으로 푸라닐, 옥사졸릴, 페닐, 피라졸릴, 피라지닐, 피리다지닐, 피리미디닐, 피롤릴, 티아졸리, 티에닐 또는 1,2,4-트리아졸릴, 바람직하게는 페닐, 피롤린, 티아졸릴 또는 티에닐이며, 각 환은 저급 알킬아미노, 저급 알킬티오, 저급 알콕시, 아미노,아지도, 시아노, 플루오로, 클로로, 브로모, 요오드, 하이드록시 및 저급 알킬, 바람직하게 저급 알킬아미노, 저급 알콕시, 아미노 플루오로, 클로로 및 저급 알킬로 이루어진 그룹중에서 선택된 1,2 또는 3개의 치환체에 의해 임의로 치환된 화합물.
  3. 제1항 또는 제2항에 있어서, R3가 수소, 메틸 또는 에틸, 바람직하게는 수소 또는 메틸을 나타내는 화합물.
  4. 제1항 내지 제3항중 어느 한 항에 있어서, n이 0,1 또는 2, 바람직하게는 0 또는 1인 화합물.
  5. 제1항 내지 제4항중 어느 한 항에 있어서, m이 0,1 또는 2, 바람직하게는 0 또는 1인 화합물.
  6. 제1항 내지 제5항중 어느 한 항에 있어서, R4가 일반식(Ⅱ)의 그룹인 화합물.
    상기식에서 R5는 수소 또는 하이드록시이거나, R5는 R6과 함께 추가의 결합을 나타내고;R6은 수소이거나, R5와 함께 추가의 결합을 나타내며;X는-NH2또는 R9(여기에서, R9은 하이드록시 또는 알콕시, 바람직하게는 하이드록시, 메톡시 또는 에톡시이다)이다.
  7. 제1항 내지 제5항중 어느 한 항에 있어서, R4가 일반식(Ⅲ)의 그룹인 화합물.
    상기식에서, R7은 수소 또는 저급 알킬 바람직하게는 수소, 메틸 또는 메틸이고, P는 1 또는 2이며, X는 -NH2또는 R9(여기에서, R9은 하이드록시 또는 알콕시, 바람직하게는 하이드록시, 메톡시 또는 에톡시이다)이다.
  8. 제1항 내지 제5항중 어느 한 항에 있어서, R4가 일반식(Ⅳ)의 그룹인 화합물.
    상기식에서, R8은 수소 또는 하이드록시, 바람직하게는 수소이고, X는 -NH2또는 R9(여기에서, R9은 하이드록시 또는 알콕시, 바람직하게는 하이드록시, 메톡시 또는 에톡시이다)을 나타낸다.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019890006609A 1988-05-18 1989-05-18 아자사이클릭 카복실산 유도체, 이의 제조방법 및 용도 KR900018058A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK270488A DK270488D0 (da) 1988-05-18 1988-05-18 Hidtil ukendte o-substituerede ketoximer
DK2704/88 1988-05-18

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KR900018058A true KR900018058A (ko) 1990-12-20

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Country Status (18)

Country Link
US (1) US5039685A (ko)
EP (1) EP0342635B1 (ko)
JP (1) JP2824661B2 (ko)
KR (1) KR900018058A (ko)
AT (1) ATE110064T1 (ko)
AU (1) AU622178B2 (ko)
CA (1) CA1337123C (ko)
DE (1) DE68917517T2 (ko)
DK (1) DK270488D0 (ko)
ES (1) ES2058383T3 (ko)
FI (1) FI93955C (ko)
IE (1) IE66016B1 (ko)
IL (1) IL90313A0 (ko)
NO (1) NO177262C (ko)
NZ (1) NZ229136A (ko)
PH (1) PH26373A (ko)
PT (1) PT90607B (ko)
ZA (1) ZA893733B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK704488D0 (da) * 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
JP2765876B2 (ja) * 1988-10-24 1998-06-18 科研製薬株式会社 ピリジルケトオキシムエーテル誘導体
DK93791D0 (da) * 1991-05-17 1991-05-17 Novo Nordisk As Nye heterocykliske carboxylsyrer
EP0767174A1 (de) * 1991-11-21 1997-04-09 Ciba-Geigy Ag Neue Aminoalkanphosphinsäuren und ihre Salze
TW266206B (ko) * 1993-04-28 1995-12-21 Takeda Pharm Industry Co Ltd
DK74393D0 (da) * 1993-06-23 1993-06-23 Novo Nordisk As Novel heterocyclic chemistry
DK74493D0 (da) * 1993-06-23 1993-06-23 Novo Nordisk As Novel heterocyclic chemistry
US5962449A (en) 1995-04-07 1999-10-05 Novo Nordisk A/S Tricyclic compounds in treating hyperalgesic conditions and NIDDM
ATE189814T1 (de) * 1996-04-15 2000-03-15 Takeda Chemical Industries Ltd Hydroxypyridin-derivate, ihre herstellung und ihre pharmazeutische verwendung
WO1997049403A1 (en) * 1996-06-27 1997-12-31 University College Dublin Use of nipecotic acid or guvacine derivatives for the manufacture of a medicament for the treatment of postischemic neurodegenerative disorders
EP1142584A4 (en) * 1999-01-12 2003-04-16 Takeda Chemical Industries Ltd COMPOSITIONS FOR THE TREATMENT OF COMMON URBANISM AND URINE CONTINENCE

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US4235931A (en) * 1967-04-05 1980-11-25 Duphar International Research B.V. Compounds having pharmacological properties
FR2162312B1 (ko) * 1971-12-10 1975-02-07 Buzas Andre
FR2248033B1 (ko) * 1973-10-19 1977-03-11 Cerpha
US4207319A (en) * 1973-10-19 1980-06-10 Albert Rolland S.A. Thienyl or furyl phenyl O-hetero amino alkyl oximes and use thereof
US4148911A (en) * 1977-07-08 1979-04-10 Societe Anonyme Dite Albert Rolland S.A. Method of treating respiratory disorders
DE2851387A1 (de) * 1977-11-28 1979-06-07 Degussa Aminoaethyloxime mit mindestens einem thienylrest und verfahren zu deren herstellung
JPS5626863A (en) * 1979-08-13 1981-03-16 Sumitomo Chem Co Ltd Novel diphenylalkanone oxime derivative
AU532700B2 (en) * 1979-04-02 1983-10-13 Sumitomo Chemical Company, Limited Diphenylalkanoether
US4722930A (en) * 1980-03-01 1988-02-02 John Wyeth And Brother Limited 3-benzoyl-1-[(oxo or thioheteroaryl-ylalkyl)-piperid-4-yl]ureas and derivatives
US4514414A (en) * 1982-10-25 1985-04-30 Smithkline Beckman Corporation N-Substituted pyrrolidineacetic acids and their esters
FI864246A (fi) * 1985-11-08 1987-05-09 Warner Lambert Co N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat.
DE3787657T2 (de) * 1986-01-07 1994-02-03 Novo Ind A S Bagsvaerd Aminosäure-Derivate.

Also Published As

Publication number Publication date
FI93955C (fi) 1995-06-26
NO891970D0 (no) 1989-05-16
IL90313A0 (en) 1989-12-15
PH26373A (en) 1992-06-01
IE891533L (en) 1989-11-18
US5039685A (en) 1991-08-13
DE68917517D1 (de) 1994-09-22
NO177262B (no) 1995-05-08
ATE110064T1 (de) 1994-09-15
FI93955B (fi) 1995-03-15
FI892388A (fi) 1989-11-19
CA1337123C (en) 1995-09-26
IE66016B1 (en) 1995-11-29
DE68917517T2 (de) 1994-12-15
EP0342635A1 (en) 1989-11-23
EP0342635B1 (en) 1994-08-17
JPH0217158A (ja) 1990-01-22
JP2824661B2 (ja) 1998-11-11
PT90607A (pt) 1989-11-30
AU3484589A (en) 1989-11-23
ES2058383T3 (es) 1994-11-01
NZ229136A (en) 1992-01-29
DK270488D0 (da) 1988-05-18
NO177262C (no) 1995-08-16
PT90607B (pt) 1995-03-01
NO891970L (no) 1989-11-20
AU622178B2 (en) 1992-04-02
FI892388A0 (fi) 1989-05-18
ZA893733B (en) 1990-02-28

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