KR890014103A - 항 바이러스성과 면역 촉진의 약학적 조성과 제조의 제조방법 - Google Patents
항 바이러스성과 면역 촉진의 약학적 조성과 제조의 제조방법 Download PDFInfo
- Publication number
- KR890014103A KR890014103A KR1019890002920A KR890002920A KR890014103A KR 890014103 A KR890014103 A KR 890014103A KR 1019890002920 A KR1019890002920 A KR 1019890002920A KR 890002920 A KR890002920 A KR 890002920A KR 890014103 A KR890014103 A KR 890014103A
- Authority
- KR
- South Korea
- Prior art keywords
- acid
- active ingredients
- lysine
- composition
- amino
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title claims 3
- 239000008194 pharmaceutical composition Substances 0.000 title claims 3
- 230000003308 immunostimulating effect Effects 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 title 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 11
- 239000004480 active ingredient Substances 0.000 claims 8
- 235000014113 dietary fatty acids Nutrition 0.000 claims 6
- 229930195729 fatty acid Natural products 0.000 claims 6
- 239000000194 fatty acid Substances 0.000 claims 6
- 150000004665 fatty acids Chemical class 0.000 claims 6
- 235000019766 L-Lysine Nutrition 0.000 claims 5
- 239000004472 Lysine Substances 0.000 claims 5
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 4
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 4
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 4
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 4
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 4
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 2
- 150000001340 alkali metals Chemical class 0.000 claims 2
- 150000001342 alkaline earth metals Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- -1 ammonium cations Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 2
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims 2
- 235000021323 fish oil Nutrition 0.000 claims 2
- 150000004677 hydrates Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002085 irritant Substances 0.000 claims 1
- 231100000021 irritant Toxicity 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 활성성분으로 생체에서 생성되는 아미노산 및/또는 C1-4알킬기, 아미노기 또는 알카리금속,알카리토류 금속 또는 암모늄 양이온에 의하여 치환된 그 유도체 또는 이들 화합물의 하이드레이트 및/또는 염류와 적어도 2개의 2중결합을 가지는 알킬기를 함유하는C18-24지방산류를 아미노산 또는 그 유도체와 지방산을 1:4 내지 4 : 1의 몰비로 함유하고 제약공업에서 통상으로 사용되는 담체 및/또는 첨가제 및 임의로 황산화제와 혼합한 항 바이러스성 및 자극성 약학적 조성물.
- 제 1항에서 불포화지방산류로서 생선의 기름에서 얻어진 지방산인 조성물.
- 제 1항에서 활성성분으로 에이코사펜탄에노익산(EPA)와 L-라이신을 함유하는 조성물.
- 제 1항에서 활성성분으로 도코사헥사에노익산(DHA)와 L-라이신을 함유하는 조성물.
- 제 1항에서 활성성분으로 도코사헥사에노익산, 에이코사펜탄에노익산 및 L-라이신을 함유하는 조성물.
- 활성성분으로 생체에서 생성되는 아미노산 및/또는 C1-4알킬기, 아미노기 또는 알카리금속,알카리토류 금속 또는 암모늄 양이온에 의하여 치환된 그 유도체 또는 이들 화합물의 하이드레이트 및/또는 염류와 적어도 2개의 2중결합을 가지는 알킬기를 함유하는C18-24지방산류를 아미노산 또는 그 유도체와 지방산을 1:4 내지 4 : 1의 몰비로 함유하고 제약공업에서 통상으로 사용되는 담체 및/또는 첨가제 및 임의로 항산화제를 혼합하여 항 바이러스성 및 면역자극성 약학적 조성물을 제조하는 방법.
- 제 6항에서 불포화 지방산으로 생선의 기름에서 얻어진 지방산을 사용하는 방법.
- 제 6항에서 활성성분으로 에이코사펜탄에노익산(EPA)와 L-라이신을 포함하는 방법.
- 제 6항에서 활성성분으로 도코사헥사에노익산(DHA)와 L-라이신을 사용하는 방법.
- 제 6항에서 활성성분으로 도코사헥사에노익산, 에이코사펜탄에노익산 및 L-라이신을 사용하는 방법.※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU881132A HU209973B (en) | 1988-03-09 | 1988-03-09 | Process for production of antiviral and immunstimular pharmaceutical composition |
HU1132/88 | 1988-03-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890014103A true KR890014103A (ko) | 1989-10-21 |
Family
ID=10952974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890002920A KR890014103A (ko) | 1988-03-09 | 1989-03-09 | 항 바이러스성과 면역 촉진의 약학적 조성과 제조의 제조방법 |
Country Status (14)
Country | Link |
---|---|
JP (1) | JPH01316316A (ko) |
KR (1) | KR890014103A (ko) |
BE (1) | BE1002890A3 (ko) |
CA (1) | CA1334576C (ko) |
CH (1) | CH678918A5 (ko) |
DE (1) | DE3907649C2 (ko) |
FI (1) | FI94591C (ko) |
FR (1) | FR2628324B1 (ko) |
GB (1) | GB2216418B (ko) |
HU (1) | HU209973B (ko) |
IT (1) | IT1229562B (ko) |
LU (1) | LU87471A1 (ko) |
NL (1) | NL8900574A (ko) |
SE (1) | SE8900828L (ko) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU210122B (en) * | 1988-03-23 | 1995-02-28 | Biorex Kutato Fejlesztoe Kft | Process for production of composition against thromboembolytic conditions of circulating system and heart |
JPH04279523A (ja) * | 1991-01-11 | 1992-10-05 | Nisshin Flour Milling Co Ltd | 免疫賦活油脂加工品 |
GB9304746D0 (en) * | 1993-03-09 | 1993-04-28 | Scotia Holdings Plc | Treatment of viral infections |
CA2159116A1 (en) * | 1993-03-26 | 1994-10-13 | Constantin Romulus Dinu | Pharmaceutical composition for the treatment of certain viruses and autoimmune diseases and the procedure of its preparation |
GB9318611D0 (en) * | 1993-09-08 | 1993-10-27 | Sandoz Nutrition Ltd | Improvements in or relating to organic compounds |
WO1995009622A1 (en) * | 1993-10-06 | 1995-04-13 | Peptide Technology Limited | Polyunsaturated fatty acids and uses thereof |
IT1264987B1 (it) * | 1993-12-14 | 1996-10-17 | Prospa Bv | Sali di un acido grasso poliinsaturo e formulazioni farmaceutiche che li contengono |
AUPM906594A0 (en) * | 1994-10-26 | 1994-11-17 | Peptide Technology Limited | Synthetic polyunsaturated fatty acid analogues |
DE19503993A1 (de) * | 1995-02-08 | 1996-08-14 | Johann Friedrich Dr Med Desaga | Verwendung eines Produktes zur enteralen Versorgung mit Lebensmittelinhaltsstoffen oder Arzneimittelinhaltsstoffen |
US5639858A (en) * | 1995-03-22 | 1997-06-17 | Tularik, Inc. | Human signal transducer and binding assays |
WO1996030381A1 (en) * | 1995-03-28 | 1996-10-03 | Novo Nordisk A/S | Immunosuppressive agents |
HU227588B1 (hu) | 2004-12-03 | 2011-09-28 | Sinnex Mueszaki Fejlesztoe Es Tanacsado Kft | Többszörösen telítetlen zsírsavak észtereit tartalmazó vírusellenes és immunstimuláns gyógyászati készítmény |
US20090192226A1 (en) * | 2007-12-17 | 2009-07-30 | Josef Neu | Materials and Methods for Treatment of Pathological Ocular Vascular Proliferation |
FR3031451B1 (fr) * | 2015-01-13 | 2018-03-23 | Greentech | Sel d'un triglyceride, preparation et utilisations |
WO2017202942A1 (en) * | 2016-05-25 | 2017-11-30 | Evonik Technochemie Gmbh | Tablets with high active ingredient content of omega-3 fatty acid amino acid salts |
EP3248467A1 (de) | 2016-05-25 | 2017-11-29 | Evonik Technochemie GmbH | Verfahren zur herstellung einer zusammensetzung enthaltend omega-3-fettsäure-l-lysin-salze |
EP3648748A1 (en) | 2017-07-06 | 2020-05-13 | Evonik Operations GmbH | Enteric coated solid dosage form comprising omega-3 fatty acid amino acid salts |
US11622952B2 (en) | 2017-08-15 | 2023-04-11 | Evonik Operations Gmbh | Tablets with high active ingredient content of omega-3 fatty acid amino acid salts |
US20220287345A1 (en) | 2019-08-08 | 2022-09-15 | Evonik Operations Gmbh | Solubility enhancement of poorly soluble actives |
EP4009956A1 (en) | 2019-08-08 | 2022-06-15 | Evonik Operations GmbH | Down streaming process for the production of polyunsaturated fatty acid salts |
DE102022003441A1 (de) | 2022-09-17 | 2024-03-28 | Jutta Ibrahim | Nahrungsergänzungsmittel Omega3 und essentielle Aminosäure(n) |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1256162A (en) * | 1968-08-16 | 1971-12-08 | Braun Fa B | Improvements in and relating to liquid products for intravenous administration |
FR2215212B1 (ko) * | 1973-01-18 | 1976-03-05 | Seperic Ch | |
FR2508797B1 (fr) * | 1981-07-03 | 1986-03-14 | Charles Chany | Medicament comprenant le produit de la reaction d'un acide carboxylique en c1 a c6 sur un amino-acide basique |
GB2118437B (en) * | 1982-03-01 | 1984-12-12 | Efamol Ltd | Composition for treating alcoholism |
US4513008A (en) * | 1982-07-30 | 1985-04-23 | The Vinoxen Company, Inc. | Virucidal compositions and therapy |
DE3229956A1 (de) * | 1982-08-12 | 1984-02-16 | Erichsen, Friedrich Karl, Dr., 2351 Schillsdorf | Arzneimittel mit cytostatischer wirkung |
DE3514328C1 (de) * | 1985-04-19 | 1986-09-11 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts, 6900 Heidelberg | Verwendung von L-Ornithin bei der selektiven Hemmung von cytotoxischen T-Lymphozyten-Effektorzellen |
DE3785667T2 (de) * | 1986-09-17 | 1994-07-21 | Clintec Nutrition Co | Zusatznahrung bzw. therapie für personen mit risiko oder in behandlung für arteriosklerotische vaskuläre, kardiovaskuläre und/oder thrombotische erkrankungen. |
AU1489688A (en) * | 1987-02-20 | 1988-09-14 | Shriners Hospitals For Crippled Children | Omega-3 fatty acids in traumatic injury treatment |
DE3726299A1 (de) * | 1987-06-26 | 1989-02-23 | Dietl Hans | Fettemulsion zur intravenoesen anwendung |
-
1988
- 1988-03-09 HU HU881132A patent/HU209973B/hu unknown
-
1989
- 1989-03-06 CH CH819/89A patent/CH678918A5/de not_active IP Right Cessation
- 1989-03-09 SE SE8900828A patent/SE8900828L/xx not_active Application Discontinuation
- 1989-03-09 BE BE8900254A patent/BE1002890A3/fr not_active IP Right Cessation
- 1989-03-09 CA CA000593270A patent/CA1334576C/en not_active Expired - Fee Related
- 1989-03-09 JP JP1055242A patent/JPH01316316A/ja active Pending
- 1989-03-09 DE DE3907649A patent/DE3907649C2/de not_active Expired - Fee Related
- 1989-03-09 IT IT8919704A patent/IT1229562B/it active
- 1989-03-09 KR KR1019890002920A patent/KR890014103A/ko not_active Application Discontinuation
- 1989-03-09 FI FI891145A patent/FI94591C/fi not_active IP Right Cessation
- 1989-03-09 FR FR8903085A patent/FR2628324B1/fr not_active Expired - Fee Related
- 1989-03-09 LU LU87471A patent/LU87471A1/fr unknown
- 1989-03-09 NL NL8900574A patent/NL8900574A/nl not_active Application Discontinuation
- 1989-03-09 GB GB8905385A patent/GB2216418B/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FI891145A (fi) | 1989-09-10 |
GB8905385D0 (en) | 1989-04-19 |
FI891145A0 (fi) | 1989-03-09 |
CH678918A5 (ko) | 1991-11-29 |
IT8919704A0 (it) | 1989-03-09 |
FR2628324A1 (fr) | 1989-09-15 |
GB2216418A (en) | 1989-10-11 |
FI94591C (fi) | 1995-10-10 |
SE8900828D0 (sv) | 1989-03-09 |
CA1334576C (en) | 1995-02-28 |
GB2216418B (en) | 1991-12-11 |
IT1229562B (it) | 1991-09-04 |
DE3907649C2 (de) | 1996-07-11 |
JPH01316316A (ja) | 1989-12-21 |
FI94591B (fi) | 1995-06-30 |
LU87471A1 (fr) | 1990-10-02 |
FR2628324B1 (fr) | 1994-05-27 |
NL8900574A (nl) | 1989-10-02 |
SE8900828L (sv) | 1989-09-10 |
DE3907649A1 (de) | 1989-09-28 |
HU209973B (en) | 1995-01-30 |
BE1002890A3 (fr) | 1991-07-16 |
HUT60432A (en) | 1992-09-28 |
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Legal Events
Date | Code | Title | Description |
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PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19890309 |
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PG1501 | Laying open of application | ||
PC1203 | Withdrawal of no request for examination | ||
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |