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KR840008018A - 트리아졸유도체의 제조방법 - Google Patents

트리아졸유도체의 제조방법 Download PDF

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Publication number
KR840008018A
KR840008018A KR1019840000916A KR840000916A KR840008018A KR 840008018 A KR840008018 A KR 840008018A KR 1019840000916 A KR1019840000916 A KR 1019840000916A KR 840000916 A KR840000916 A KR 840000916A KR 840008018 A KR840008018 A KR 840008018A
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KR
South Korea
Prior art keywords
formula
salt
base
triazole
product
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KR1019840000916A
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English (en)
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KR870000356B1 (ko
Inventor
리챠드슨(외 1) 케네드
Original Assignee
윌리암 죤 윌슨
화이자 코포레이숀
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Publication of KR840008018A publication Critical patent/KR840008018A/ko
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Publication of KR870000356B1 publication Critical patent/KR870000356B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.

Description

트리아졸유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 하기 일반식(Ⅱ)의 옥시란을 1,2,4-트리아졸 또는 이것의 염기 염과 반응시킨 후, 임의로 하기 일반(I)의 생성물을 약학적으로 또는 농업적으로 허용되는 염으로 전환시키고/시키거나, 필요에 따라, 상기 생성물을 디아스테레오이성체 쌍으로 분리시킴을 특징으로 하여 하기 일반식(I)의 트리아졸 또는 이것의 약학적으로나 농업적으로 허용되는 염을 제조하는 방법.
  3. 상기 일반식에서 R은 1내지 3개의 치환체에 의해 임의로 치환된 페닐(이들 치환체 각각은 독립적으로 F,Cl,Br, I, CF3, C1-C4알킬 또는 C1-C|4알콕시이다), 또는 5-클로로-피리드-2-일이고; R1은 H, CH3또는 F이다.
  4. 제1항에 있어서, 옥시란(Ⅱ)를 염기의 존재하에 1,2,4-트리아졸과 반응시킴을 특징으로 하는 방법.
  5. 제2항에 있어서, 염기가 탄산칼륨임을 특징으로 하는 방법.
  6. 제1항에 있어서, 염기염이 1,2,4-트리아졸의 알칼리 금속염임을 특징으로 하는 방법.
  7. 제4항에 있어서, 알칼리금속염이 나트륨 또는 칼륨염 임을 특징으로 하는 방법.
  8. 제1내지 5항중 어느 한항에 있어서, 반응을 40 내지 120℃의 온도에서, 유기용매내에서 수행함을 특징으로 하는 방법.
  9. 제1내지 6항중 어느 한항에 있어서, R이 F,Cl,Br, I 및 CF3중에서 각각 독립적으로 선택한 1개 또는 2개의 치환체에 의해 치환된 페닐그룹임을 특징으로 하는 방법.
  10. 제7항에 있어서, R이 2,4-디플루오로페닐, 2,4-디클로로페닐, 4-플루오로페닐 또는 4-클로로페닐임을 특징으로 하는 방법.
  11. 제1 내지 8항중 어느 한항에 있어서, R1이 H또는 F임을 특징으로 하는 방법.
  12. 제1 내지 9항중 어느 한항에 있어서, R1이 H이고, R은 2,4-디플루로오페닐임을 특징으로 하는 방법.
  13. 제10항에 있어서, 일반식(I)의 생성물을 크로마토그래피하여 그것의 디아스테레오 이성체쌍으로 분리함을 특징으로 하는 방법.
  14. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840000916A 1983-02-25 1984-02-24 트리아졸 유도체의 제조 방법 KR870000356B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB83/05377 1983-02-25
GB8305377 1983-02-25
GB838305377A GB8305377D0 (en) 1983-02-25 1983-02-25 Antifungal agents

Publications (2)

Publication Number Publication Date
KR840008018A true KR840008018A (ko) 1984-12-12
KR870000356B1 KR870000356B1 (ko) 1987-03-05

Family

ID=10538659

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840000916A KR870000356B1 (ko) 1983-02-25 1984-02-24 트리아졸 유도체의 제조 방법

Country Status (28)

Country Link
US (1) US4960782A (ko)
EP (1) EP0118245B1 (ko)
JP (1) JPS59193877A (ko)
KR (1) KR870000356B1 (ko)
AU (1) AU545660B2 (ko)
CA (1) CA1257276A (ko)
CS (1) CS241047B2 (ko)
DD (1) DD216457A5 (ko)
DE (1) DE3463655D1 (ko)
DK (2) DK160823C (ko)
ES (1) ES529992A0 (ko)
FI (1) FI80683C (ko)
GB (1) GB8305377D0 (ko)
GR (1) GR79816B (ko)
HK (1) HK32389A (ko)
HU (1) HU190545B (ko)
IE (1) IE57056B1 (ko)
IL (1) IL71042A (ko)
IN (1) IN161372B (ko)
NO (1) NO161559C (ko)
NZ (1) NZ207256A (ko)
PH (1) PH20060A (ko)
PL (1) PL142674B1 (ko)
PT (1) PT78128B (ko)
SG (1) SG6589G (ko)
SU (1) SU1405701A3 (ko)
YU (1) YU42634B (ko)
ZA (1) ZA841322B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3461637D1 (en) * 1983-02-16 1987-01-22 Pfizer Ltd Triazole antifungal agents
US4690942A (en) * 1983-12-20 1987-09-01 Ciba-Geigy Corporation 1-aryl-2-fluoro-2-azolyl alkanones, alkanols, esters, and ethers, composition containing them, and use of them to control phytopathogenic microorganisms
IE58738B1 (en) * 1984-09-05 1993-11-03 Ici Plc Antifungal azole compounds
EP0228995A1 (de) * 1985-12-20 1987-07-15 Ciba-Geigy Ag Mikrobizide
DE3825841A1 (de) * 1988-07-29 1990-02-01 Basf Ag 1-halogen-1-azolypropene und -methyloxirane und diese enthaltende fungizide
FR2661176B1 (fr) * 1990-04-20 1992-06-12 Adir Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive.
DE4034352A1 (de) * 1990-10-29 1992-04-30 Basf Ag 1-halogen-1-azolylmethanderivate und diese enthaltende fungizide
TW210334B (ko) * 1990-12-12 1993-08-01 Ciba Geigy Ag
US5488035A (en) * 1991-12-06 1996-01-30 Pioneer Hi-Bred International, Inc. Peptide with inhibitory activity towards plant pathogenic fungi
JP3471831B2 (ja) * 1991-12-09 2003-12-02 富山化学工業株式会社 新規なトリアゾール誘導体およびその塩
US5360612A (en) * 1992-10-13 1994-11-01 Pfizer Inc. Pharmaceutical compositions containing triazole derivatives for rectal administration
EA025266B1 (ru) 2011-06-23 2016-12-30 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
BR112014017751B1 (pt) * 2012-01-20 2021-12-07 Mycovia Pharmaceuticals, Inc Compostos inibidores de metaloenzima, composições compreendendo os ditos compostos e uso dos ditos compostos
TWI646088B (zh) * 2012-03-16 2019-01-01 維愛美製藥公司 金屬酶抑制劑化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2918894A1 (de) * 1979-05-10 1980-11-20 Bayer Ag Fluorierte 1-triazolyl-butan-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
DE2938534A1 (de) * 1979-09-24 1981-04-23 Bayer Ag, 5090 Leverkusen Acylierte triazolyl-(gamma)-fluorpinakolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
GB2078719B (en) * 1980-06-02 1984-04-26 Ici Ltd Heterocyclic compounds
DE3033592A1 (de) * 1980-09-06 1982-04-22 Bayer Ag, 5090 Leverkusen Fluorierte 1-azolyl-butan-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
EP0069442B1 (en) * 1981-06-06 1985-02-20 Pfizer Limited Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
DE3210570A1 (de) * 1982-03-23 1983-10-06 Hoechst Ag 3-azolyl-1,2-diaryl-1-halogen-1-propene, ihre herstellung, ihre verwendung als pflanzenschutzmittel und diese verbindungen enthaltende praeparate
GR79307B (ko) * 1982-06-09 1984-10-22 Pfizer
US4510148A (en) * 1982-06-12 1985-04-09 Pfizer Inc. 2-Heterocyclic-1,3-bis(1H-1,2,4-triazol-1-yl)-propan-2-ols as antifungal agents
US4518604A (en) * 1983-07-25 1985-05-21 Pfizer Inc. Antifungal 1-aryl-2-(1H-1,2,4-triazol-1yl)-1-perfluoroalkylethyl halides
US4690942A (en) * 1983-12-20 1987-09-01 Ciba-Geigy Corporation 1-aryl-2-fluoro-2-azolyl alkanones, alkanols, esters, and ethers, composition containing them, and use of them to control phytopathogenic microorganisms

Also Published As

Publication number Publication date
FI840764A (fi) 1984-08-26
DK369889D0 (da) 1989-07-27
GR79816B (ko) 1984-10-31
EP0118245A1 (en) 1984-09-12
PL142674B1 (en) 1987-11-30
IE57056B1 (en) 1992-04-08
KR870000356B1 (ko) 1987-03-05
DK160823B (da) 1991-04-22
GB8305377D0 (en) 1983-03-30
DD216457A5 (de) 1984-12-12
IL71042A (en) 1987-07-31
CS241047B2 (en) 1986-03-13
FI840764A0 (fi) 1984-02-24
ES8506653A1 (es) 1985-07-16
ES529992A0 (es) 1985-07-16
NO161559C (no) 1989-08-30
YU42634B (en) 1988-10-31
AU2504084A (en) 1984-08-30
EP0118245B1 (en) 1987-05-13
IE840451L (en) 1984-08-25
DK97884D0 (da) 1984-02-24
ZA841322B (en) 1985-10-30
SU1405701A3 (ru) 1988-06-23
DE3463655D1 (en) 1987-06-19
HUT34012A (en) 1985-01-28
IL71042A0 (en) 1984-05-31
PT78128B (en) 1986-07-17
YU33584A (en) 1986-08-31
NZ207256A (en) 1986-07-11
CA1257276A (en) 1989-07-11
NO840721L (no) 1984-08-27
JPS6411631B2 (ko) 1989-02-27
AU545660B2 (en) 1985-07-25
FI80683B (fi) 1990-03-30
US4960782A (en) 1990-10-02
PT78128A (en) 1984-03-01
DK369889A (da) 1989-07-27
HU190545B (en) 1986-09-29
SG6589G (en) 1989-06-09
DK97884A (da) 1984-08-26
DK160823C (da) 1991-10-07
IN161372B (ko) 1987-11-21
HK32389A (en) 1989-04-28
NO161559B (no) 1989-05-22
PL246356A1 (en) 1985-02-27
JPS59193877A (ja) 1984-11-02
PH20060A (en) 1986-09-18
DK171233B1 (da) 1996-08-05
FI80683C (fi) 1990-07-10
CS127684A2 (en) 1985-06-13

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