KR840006979A - 1-아졸릴-2-아릴-3-플루오로알칸-2-올유도체의 제조방법 - Google Patents
1-아졸릴-2-아릴-3-플루오로알칸-2-올유도체의 제조방법 Download PDFInfo
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- triazol
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- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (38)
- 하기식(II)의 옥시란을 하기식(III)의 아졸과 반응시켜 생성된 하기식(Ia)의 알코올을 하기식(IV)의 화합물과 반응시켜 에테르로 전환시키는 것으로 구성된 하기식(I)의 1―아졸릴―2―아릴―3―플로오로알칸―2―올유도체 및 산부가염, 4차 아졸률염과 금속착물의 제조방법.
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- 상기식에서
- Az는 1H―1,2,4―트리아졸, 4H―1,2,4―트리아졸 또는 1H―이미다졸
- Ar은 치환되지 않았거나 치환된 방향 족 라디칼로 페닐, 비페닐, 페녹시페닐, 나프틸로부터 선택된다.
- R1은 수소, C1―C4―알킬, C3―C5―알케닐, 벤질
- R2는 수소, C1―C6―알킬
- R3는 수소, 불소, C1―C6알킬, C1―C6―할로알킬, C1―C6―알콕시, C1―C6―알킬티오, 페닐, 페녹시, 페닐티오, C3―C7―시클로알킬인데 각각의 방향족 치환체 또는 치환체의 방향족부는 치환되지 않거나 할로겐 C1―C4―알킬, C1―C4―알콕시, C1―C4―할로알킬, 니트로 및/혹은 시아노로 단일―또는 다중 치환된다.
- M은 수소 또는 금속원자
- W는 OH 또는 종래의 이탈기.
- 제1항에 있어서, 식(II)의 옥시란과 식(III)의 아졸을 상대적으로 극성이지만 반응에 불활성인 용매내에서 0°―150℃ 양호하게는 20°―100℃로 반응시키는 제조방법.
- 제1 또는 2항에 있어서, Az가 치환되지 않았거나 페닐, 비페닐과 페녹시로 치환된 방향족 라디칼: R1이 수소, R2가 수소, 불소 또는 C1―C3―알킬; R3이 수소, 불소, C1―C4―알킬, C1―C3―할로알킬, C1―C3알콕시, C1―C3알킬티오, 페닐, 페녹시 또는 페닐티오며 각각의 페닐부는 치환되지 않았거나 불소, 염소, 브롬, 메틸, 메톡시, CF3, NO2및/혹은 시아노로 치환된 식(I)의 화합물 및 산부가염, 4차 아졸륨염과 금속 착물의 제조방법.
- 제3항에 있어서, Az가 1H―1,2,4―트리아졸, Ar이 페닐 또는 페녹시페닐로 치환되지 않았거나 2―/및 혹은 4―위치가 메틸 또는 할로겐으로 치환되었으며: R1은 수소: R2는 수소, 불소 또는 메틸: R3은 수소, 불소, C1―C4알킬 또는 페닐, 페녹시와 페닐티오로부터 선택된 라디칼로서 불소, 염소 및/혹은 브롬으로 치환된 식(I)의 화합물의 제조방법.
- 제1 또는 2항에 있어서,
- 1-(1H-1,2,4-트리아졸-1-일)-2-(2,4-디클로로페닐)-3-플루오로부탄-2-올,
- 1-(1H-1,2,4-트리아졸-1-일)-2-(2-클로로-4-플루오로페닐)-3-플루오로부탄-2-올,
- 1-(1H-1,2,4-트리아졸-1-일)-2-(2,4-디클로로페닐)-3-플루오로부탄-2-올,
- 1-(1H-1,2,4-트리아졸-1-일)-2-(2,4-디클로로페닐)-3-플루오로-4-메틸페탄-2-올,
- 1-(1H-1,2,4-트리아졸-1-일)-2-(2-클로로-4-플루오로페닐)-3-플루오로펜탄-2-올,
- 1-(1H-1,2,4-트리아졸-1-일)-2-[P-(4-클로로페녹시)페닐]-3-플루오로프로판-2-올,
- 1-(1H-1,2,4-트리아졸-1-일)-2-(2,4-디클로롤페닐)-3-(4-클로로페녹시)-3-플루오로프로판-2-올,
- 1-(1--1,2,4-트리아졸-1-일)-2-(4-플루오로페닐)-3,3,3-트리플루오로프로판-2-올,
- 1-(1H-1,2,4-트라아졸-1-일)-2-(2,4-디클로로페닐)-3,3,3-트리플루오로 플로판-2-올 중에서 선택된 식(I)의 화합물의 제조방법.
- 제1 또는 2항에 있어서,
- 1―(1H―1,2,4―트리아졸―1―일)―2―(4―클로로페닐)―3―플루오로헥산―2―올,
- 1―(1H―1,2,4―트리아졸―1―일)―2―(2,4―디클로로페닐)―3―플루오로헥산―2―올,
- 1―(1H―1,2,4―트리아졸―1―일)―2―(2,4―디클로로페닐)―3,3―디플루오로펜탄―2―올,
- 1―(1H―1,2,4―트리아졸―1―일)―2―(2,4―디클로로페닐)―3―플루오로-4-메틸펜탄-2-올,
- 1―(1H―1,2,4―트리아졸―1―일)―2―[P-(4-브로모페녹시)페닐]-3,3-디플루오로프로판-2-,올
- 1―(1H―1,2,4―트리아졸―1―일)―2―[P-(4-플루오로페녹시)페닐]-3,3-디플루오로프로판-2-올,
- 1―(1H―1,2,4―트리아졸―1―일)―2―[P-(4-클로로페녹시)페닐]-3,3-디플루오로프로판-2-올,
- 1―(1H―1,2,4―트리아졸―1―일)―2―[P-(4-클로로페녹시)-2-메틸페닐]-2-히드록시-3-프루오로 프로판 중에서 선택된 식(I)의 화합물의 제조방법.
- 1―아졸릴―2―아릴―3―플루오로알칸―2―올 유도체의 제조방법.
- ※참고사항:최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH726982 | 1982-12-14 | ||
CH7269/82 | 1982-12-14 | ||
CH7269/82-0 | 1982-12-14 |
Publications (2)
Publication Number | Publication Date |
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KR840006979A true KR840006979A (ko) | 1984-12-04 |
KR910002541B1 KR910002541B1 (ko) | 1991-04-23 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1019830005924A KR910002541B1 (ko) | 1982-12-14 | 1983-12-14 | 1-아졸릴-2-아릴-3-플루오로알칸-2-올유도체의 제조방법 |
Country Status (29)
Country | Link |
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EP (1) | EP0113640B1 (ko) |
JP (1) | JPS59118771A (ko) |
KR (1) | KR910002541B1 (ko) |
AR (1) | AR240810A1 (ko) |
AT (1) | ATE53027T1 (ko) |
AU (2) | AU570659B2 (ko) |
BG (1) | BG48681A3 (ko) |
BR (1) | BR8306860A (ko) |
CA (1) | CA1209152A (ko) |
CS (1) | CS250237B2 (ko) |
DD (1) | DD215930A5 (ko) |
DE (1) | DE3381589D1 (ko) |
DK (1) | DK161199C (ko) |
ES (1) | ES527986A0 (ko) |
FI (1) | FI83776C (ko) |
GB (2) | GB2132195B (ko) |
GR (1) | GR81348B (ko) |
HU (2) | HU196978B (ko) |
IE (1) | IE56378B1 (ko) |
IL (1) | IL70422A (ko) |
MA (1) | MA19972A1 (ko) |
NO (1) | NO161256C (ko) |
NZ (1) | NZ206562A (ko) |
PH (1) | PH22949A (ko) |
PL (1) | PL139146B1 (ko) |
PT (1) | PT77797B (ko) |
SU (1) | SU1326194A3 (ko) |
TR (1) | TR22109A (ko) |
ZA (1) | ZA839259B (ko) |
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GB8520027D0 (en) * | 1985-08-09 | 1985-09-18 | Ici Plc | Insecticidal ethers |
US4935436A (en) * | 1989-01-23 | 1990-06-19 | The Dow Chemical Company | Substituted triazoles and their use as fungicides |
US5140023A (en) * | 1990-04-27 | 1992-08-18 | G. D. Searle & Co. | Azatetracycle compounds |
JP3471831B2 (ja) * | 1991-12-09 | 2003-12-02 | 富山化学工業株式会社 | 新規なトリアゾール誘導体およびその塩 |
HU212424B (en) * | 1993-09-23 | 1996-06-28 | Richter Gedeon Vegyeszet | New propan-2-ol derivatives substituted with triazole or imidazole and process for producing them |
US6002028A (en) * | 1995-12-22 | 1999-12-14 | Ss Pharmaceutical Co., Ltd. | Triazole derivative, preparation process thereof and pharmaceutical comprising the same as an effective ingredient |
EP0780380B1 (en) * | 1995-12-22 | 2001-06-13 | Ss Pharmaceutical Co., Ltd. | Triazole derivatives with antimycotic action and intermediates |
US5939448A (en) * | 1996-06-21 | 1999-08-17 | Ss Pharmaceutical Co., Ltd. | Triazole derivative or salt thereof |
TW438784B (en) * | 1997-08-29 | 2001-06-07 | Ssp Co Ltd | Triazole derivative or salt thereof and pharmaceutical composition for treating mycosis containing the same |
JP3638438B2 (ja) * | 1997-12-26 | 2005-04-13 | エスエス製薬株式会社 | トリアゾール誘導体またはその塩、その製造方法及び当該化合物を有効成分とする医薬 |
JP2004359646A (ja) * | 2003-06-09 | 2004-12-24 | Ss Pharmaceut Co Ltd | 抗真菌活性を有する新規アゾール誘導体 |
MX356322B (es) | 2011-07-13 | 2018-05-23 | Basf Se | Compuestos sustituidos fungicidas de 2-[2-halogenalquil-4-(fenoxi) -fenil]-1-[1,2,4]triaxol-1-il-etanol. |
BR112014000821A2 (pt) | 2011-07-15 | 2016-08-23 | Basf Se | compostos, processo, composições agroquímicas, uso de compostos da fórmula i, método para combate de fungos nocivos e semente |
CN103648281B (zh) | 2011-07-15 | 2016-05-25 | 巴斯夫欧洲公司 | 杀真菌的烷基取代的2-[2-氯-4-(4-氯苯氧基)苯基]-1-[1,2,4]三唑-1-基乙醇化合物 |
WO2013010885A1 (en) | 2011-07-15 | 2013-01-24 | Basf Se | Fungicidal alkyl- and aryl-substituted 2-[2-chloro-4-(dihalo-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds |
EA201400234A1 (ru) | 2011-08-15 | 2014-07-30 | Басф Се | Фунгицидные замещенные 1-{2-[2-галоген-4(4-галогенфенокси)фенил]-2-алкинилоксиэтил}-1н-[1,2,4]триазолные соединения |
JP2014525405A (ja) | 2011-08-15 | 2014-09-29 | ビーエーエスエフ ソシエタス・ヨーロピア | 殺菌性置換1−{2−[2−ハロ−4−(4−ハロゲン−フェノキシ)−フェニル]−2−アルコキシ−3−メチル−ブチル}−1h−[1,2,4]トリアゾール化合物 |
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JP2014529594A (ja) | 2011-08-15 | 2014-11-13 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 殺菌性置換1−{2−シクリルオキシ−2−[2−ハロ−4−(4−ハロゲン−フェノキシ)−フェニル]−エチル}−1h−[1,2,4]トリアゾール化合物 |
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DE2912288A1 (de) * | 1979-03-28 | 1980-10-09 | Bayer Ag | Verfahren zur herstellung von hydroxyethyl-azolen |
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US4616027A (en) * | 1982-08-14 | 1986-10-07 | Pfizer Inc. | Antifungal 1-aryl-1-fluoroalkyl-2-(1H-1,2,4-triazol-1-yl)ethanols |
DE3237400A1 (de) * | 1982-10-08 | 1984-04-12 | Bayer Ag, 5090 Leverkusen | Substituierte 1-hydroxyethyl-triazolyl-derivate |
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EP0117100B1 (en) * | 1983-02-16 | 1986-12-10 | Pfizer Limited | Triazole antifungal agents |
GB8520027D0 (en) * | 1985-08-09 | 1985-09-18 | Ici Plc | Insecticidal ethers |
DE3780291T2 (de) * | 1987-01-08 | 1993-01-07 | Ici Plc | Insektizide aether. |
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1983
- 1983-12-06 BG BG063332A patent/BG48681A3/xx unknown
- 1983-12-07 GB GB08332617A patent/GB2132195B/en not_active Expired
- 1983-12-08 DE DE8383810576T patent/DE3381589D1/de not_active Expired - Lifetime
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- 1983-12-08 AT AT83810576T patent/ATE53027T1/de not_active IP Right Cessation
- 1983-12-09 FI FI834522A patent/FI83776C/fi not_active IP Right Cessation
- 1983-12-09 MA MA20193A patent/MA19972A1/fr unknown
- 1983-12-09 PT PT77797A patent/PT77797B/pt not_active IP Right Cessation
- 1983-12-12 DD DD83257812A patent/DD215930A5/de not_active IP Right Cessation
- 1983-12-12 CA CA000443044A patent/CA1209152A/en not_active Expired
- 1983-12-12 AR AR295072A patent/AR240810A1/es active
- 1983-12-12 IL IL70422A patent/IL70422A/xx unknown
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- 1983-12-12 CS CS839326A patent/CS250237B2/cs unknown
- 1983-12-12 GR GR73213A patent/GR81348B/el unknown
- 1983-12-12 SU SU833675009A patent/SU1326194A3/ru active
- 1983-12-12 PL PL1983245063A patent/PL139146B1/pl unknown
- 1983-12-13 ES ES527986A patent/ES527986A0/es active Granted
- 1983-12-13 BR BR8306860A patent/BR8306860A/pt unknown
- 1983-12-13 AU AU22345/83A patent/AU570659B2/en not_active Ceased
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- 1983-12-13 IE IE2933/83A patent/IE56378B1/en not_active IP Right Cessation
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- 1983-12-13 DK DK573883A patent/DK161199C/da not_active IP Right Cessation
- 1983-12-13 HU HU834246A patent/HU196891B/hu not_active IP Right Cessation
- 1983-12-13 NZ NZ206562A patent/NZ206562A/xx unknown
- 1983-12-14 JP JP58236016A patent/JPS59118771A/ja active Pending
- 1983-12-14 PH PH29977A patent/PH22949A/en unknown
- 1983-12-14 KR KR1019830005924A patent/KR910002541B1/ko not_active IP Right Cessation
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1985
- 1985-09-04 GB GB08522010A patent/GB2166729B/en not_active Expired
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