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KR840006977A - 치환된 페닐설포닐옥시벤즈이미다졸 카바메이트의 제조방법 - Google Patents

치환된 페닐설포닐옥시벤즈이미다졸 카바메이트의 제조방법 Download PDF

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Publication number
KR840006977A
KR840006977A KR1019830006059A KR830006059A KR840006977A KR 840006977 A KR840006977 A KR 840006977A KR 1019830006059 A KR1019830006059 A KR 1019830006059A KR 830006059 A KR830006059 A KR 830006059A KR 840006977 A KR840006977 A KR 840006977A
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South Korea
Prior art keywords
formula
carbon atoms
carbamate
substituted
bromine
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KR1019830006059A
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English (en)
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KR910000045B1 (ko
Inventor
뢰즈너(외 3) 만프레트
Original Assignee
하인리히 벡커, 베른 하르트 벡크
훽스트 아크티엔 게젤샤프트
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Publication of KR840006977A publication Critical patent/KR840006977A/ko
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Publication of KR910000045B1 publication Critical patent/KR910000045B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

치환된 페닐설포닐옥시벤즈이미다졸 카바메이트의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 일반식(II)의 치환된 0―페닐렌디아민 유도체를 일반식(III)의 카밤산 에스테르 유도체와 반응시키거나, 일반식(IV)의 벤즈이미다졸 카바메이트를 일반식(V)의 치환된 벤젠설포닐할라이드와 반응시키거나, 일반식(VI)의 2―아미노 벤즈 이미다졸을 일반식(VII)의 탄산 에스테르 유도체와 반응시킴을 특징으로 하여 일반식(I)의 치환된 페닐설포닐옥시벤즈이미다졸 카바메이트를 제조하는 방법.
  6. 상기식에서
  7. R1은 탄소수 1 내지 4의 직쇄 또는 측쇄 알킬을 나타내고;
  8. n은 1 또는 2를 나타내며, 각각의 치환기 R2는 서로 독립적으로 불소, 브롬, 1,1,2,2―테트라플루오로에톡시, 탄소수 2 내지 4의 알킬 또는 탄소수 3 내지 8의 사이클로알킬을 나타내고;
  9. R3는 CN을 나타내며, R4는 수소를 나타내거나 R3및 R4가 함께 질소원자와 이중 결합하는 다음의 라디칼
  11. (이때 R5는 탄소수 1 내지 4의 알킬을 나타내고, R6는 수소 또는 ―COOR1을 나타내며, Z는 산소 또는 황을 나타낸다) 중이 하나를 나타내며; X는 불소, 염소, 브롬 또는 요오드를 나타내고;
  12. Y는 ―OR1또는 염소를 나타낸다.
  13. 제1항에 있어서, R1이 메틸을 나타내고, n이 1 및 2를 나타내며, R2가 불소, 브롬, 1,1,2,2―테트라플루오로에톡시, 에틸, n―프로필, 이소프로필 또는 탄소수 5, 6 또는 7의 사이클로알킬을 나타내는 일반식(I)의 페닐설포닐 옥시벤즈이미다졸 카바메이트를 제조하는 방법.
  14. ※참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019830006059A 1982-12-23 1983-12-21 치환된 페닐설포닐옥시벤즈이미다졸 카바메이트의 제조방법 KR910000045B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3247615.9 1982-12-23
DE19823247615 DE3247615A1 (de) 1982-12-23 1982-12-23 Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
KR840006977A true KR840006977A (ko) 1984-12-04
KR910000045B1 KR910000045B1 (ko) 1991-01-19

Family

ID=6181486

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830006059A KR910000045B1 (ko) 1982-12-23 1983-12-21 치환된 페닐설포닐옥시벤즈이미다졸 카바메이트의 제조방법

Country Status (23)

Country Link
US (1) US4639463A (ko)
EP (1) EP0115039B1 (ko)
JP (1) JPS59118774A (ko)
KR (1) KR910000045B1 (ko)
AR (1) AR241017A1 (ko)
AT (1) ATE32459T1 (ko)
AU (1) AU558902B2 (ko)
CA (1) CA1199642A (ko)
DE (2) DE3247615A1 (ko)
DK (1) DK150065C (ko)
ES (1) ES528243A0 (ko)
FI (1) FI834709A (ko)
GR (1) GR79454B (ko)
HU (1) HU192972B (ko)
IL (1) IL70520A (ko)
MA (1) MA19985A1 (ko)
MY (1) MY100900A (ko)
NO (1) NO834773L (ko)
NZ (1) NZ206658A (ko)
PH (1) PH21374A (ko)
PT (1) PT77876B (ko)
ZA (1) ZA839534B (ko)
ZM (1) ZM9283A1 (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9115273D0 (en) * 1991-07-15 1991-08-28 Pfizer Ltd Benzimidazole anthelmintics
GB9115272D0 (en) * 1991-07-15 1991-08-28 Pfizer Ltd Benzimidazole anthelmintics
GB9124002D0 (en) * 1991-11-12 1992-01-02 Pfizer Ltd Benzimidazole anthelmintic agents
SE9103745D0 (sv) * 1991-12-18 1991-12-18 Wikstroem Haakan Aryl-triflates and related compounds
GB0100889D0 (en) * 2001-01-12 2001-02-21 Oxford Glycosciences Uk Ltd Compounds
EP1298125A1 (en) * 2001-09-26 2003-04-02 Aventis Pharma S.A. Substituted benzimidazole compounds and their use for the treatment of cancer
AU2003248960B2 (en) * 2002-07-17 2009-06-25 Idorsia Pharmaceuticals Ltd Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase
JP4575156B2 (ja) * 2002-07-17 2010-11-04 アクテリオン ファーマシューティカルズ リミテッド グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体
GB0313677D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compound
GB0313678D0 (en) * 2003-06-13 2003-07-16 Oxford Glycosciences Uk Ltd Novel compounds
FR2868421B1 (fr) * 2004-04-01 2008-08-01 Aventis Pharma Sa Nouveaux benzothiazoles et leur utilisation comme medicaments
PT1913009E (pt) * 2005-07-28 2010-06-25 Intervet Int Bv Novos (tio)carbamatos de benzimidazole com actividade antiparasitária e sua síntese
FR2891273B1 (fr) * 2005-09-27 2007-11-23 Aventis Pharma Sa NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet
CN102283698B (zh) * 2006-06-12 2016-02-24 史密夫和内修有限公司 用于进行胫骨切除的引导装置
AR061351A1 (es) 2006-06-14 2008-08-20 Intervet Int Bv Composicion de carbamato de bencimidazol
CN1966495B (zh) * 2006-09-15 2010-06-16 常州亚邦齐晖医药化工有限公司 制备5-(4-氟苯磺酰氧基)苯并咪唑-2-氨基甲酸甲酯的方法
CN102060780B (zh) * 2010-12-27 2014-11-05 雅本化学股份有限公司 2-(n-取代)-氨基苯并咪唑衍生物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA562096A (en) * 1958-08-19 J. Cavallito Chester Quaternary ammonium salts of pyridindole derivatives
DE54507C (de) * F. A. LAESECKE in Leipzig Zerlegbarer Rüstbock
GB764232A (en) * 1954-02-12 1956-12-19 Irwin Neisler And Company Quaternary ammonium salts of pyridindole derivatives
ES273769A1 (es) * 1961-01-18 1962-06-01 Geigy Ag J R Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
DE2441201C2 (de) * 1974-08-28 1986-08-07 Hoechst Ag, 6230 Frankfurt Anthelminthisch wirksame 2-Carbalkoxyamino-5(6)-phenyl-sulfonyloxy-benzimidazole und Verfahren zu ihrer Herstellung
JPS5914027B2 (ja) * 1976-02-27 1984-04-02 ヘキスト・アクチ−エンゲゼルシヤフト ２−カルボアルコキシアミノ−５（６）−フエニルスルホニルオキシ−ベンズイミダゾ−ル化合物
JPS5910350A (ja) * 1982-07-07 1984-01-19 井関農機株式会社 籾摺機のロ−タリ−セパレ−タ
JPS5914027A (ja) * 1982-07-15 1984-01-24 Canon Inc 印字装置付電子機器

Also Published As

Publication number Publication date
AR241017A2 (es) 1991-04-30
FI834709A0 (fi) 1983-12-21
GR79454B (ko) 1984-10-30
DK150065C (da) 1987-10-26
AU2280883A (en) 1984-06-28
EP0115039B1 (de) 1988-02-10
DE3375659D1 (en) 1988-03-17
IL70520A0 (en) 1984-03-30
AR241017A1 (es) 1991-04-30
DK593883D0 (da) 1983-12-22
PT77876B (de) 1986-04-21
NZ206658A (en) 1986-06-11
JPH0434545B2 (ko) 1992-06-08
MA19985A1 (fr) 1984-07-01
CA1199642A (en) 1986-01-21
ES8406448A1 (es) 1984-08-01
ES528243A0 (es) 1984-08-01
ATE32459T1 (de) 1988-02-15
JPS59118774A (ja) 1984-07-09
HU192972B (en) 1987-08-28
US4639463A (en) 1987-01-27
PH21374A (en) 1987-10-15
IL70520A (en) 1988-01-31
NO834773L (no) 1984-06-25
AU558902B2 (en) 1987-02-12
MY100900A (en) 1991-05-16
ZM9283A1 (en) 1984-06-21
DK150065B (da) 1986-12-01
DE3247615A1 (de) 1984-07-05
KR910000045B1 (ko) 1991-01-19
DK593883A (da) 1984-06-24
PT77876A (de) 1984-01-01
EP0115039A1 (de) 1984-08-08
FI834709A (fi) 1984-06-24
ZA839534B (en) 1984-08-29

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