KR20240095363A - 유전자에 기반한 염증성 장 질환의 진단 - Google Patents
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Abstract
본 발명은 대상체에서 염증성 장 질환(IBD: inflammatory bowel disease) 발병의 저확률 또는 고확률을 예측하는 방법, 및 대상체에서 염증성 장 질환(IBD)을 진단하는 방법을 기술한다. 또한, 본 발명은 IBD, CD 및/또는 UC와 같은 질병 상태와 관련된 유전자/유전자좌를 확인하는 방법을 제공한다.
Description
연방 후원 연구에 관한 진술
본 발명은 미국 국립 보건원(National Institutes of Health)에 의해 부여된 허가 번호 DK108140 및 DK062413 하에 정부 지원으로 이루어졌다. 정부는 발명에 대해 특정 권리를 가진다.
발명의 분야
본 발명은 유전학 및 의학에 관한 것이다.
본원에 인용된 모든 간행물은 각각의 개별 간행물 또는 특허 출원이 참조로 포함된다고 구체적으로 그리고 개별적으로 나타낸 것과 같이 동일한 정도로 그 전문이 참고로 포함된다. 하기 설명은 본 발명을 이해하는데 유용할 수 있는 정보를 포함한다. 본원에 제공된 정보가 선행 기술임을 또는 현재 청구된 발명과 관련이 있음을 인정하거나, 구체적으로 또는 암시적으로 참조된 간행물이 선행 기술임을 인정하는 것은 결코 아니다.
특발성 염증성 장 질환(IBD: inflammatory bowel disease)의 두 가지 일반적인 형태인 크론병(CD: Crohn's disease) 및 궤양성 대장염(UC: ulcerative colitis)은 위장관의 만성적인 재발성 염증 장애이다. 각각은 삶의 20 내지 40세에 최고 발병 연령을 보이며 유럽 조상 집단에서 10만 명당 평균 약 100 내지 150명의 유병률을 보인다(D.K. Podolsky, N Engl J Med 347, 417 (2002); E.V. Loftus, Jr., Gastroenterology 126, 1504 (2004)). IBD의 정확한 병인은 아직 밝혀지지 않았지만, 편재하는 공생 장내 박테리아가 유전적으로 감수성이 있는 개체에서 장 조직 손상을 매개하는 부적절한, 과민성 및 진행성 점막 면역 반응을 유발한다는 가설이 널리 받아들여지고 있다(D.K. Podolsky, N Engl J Med 347, 417 (2002)). 아슈케나지(Ashkenazi) 유대인에서 IBD의 비율 증가, IBD의 가족 집적 및 이란성 쌍생아에 비해 일란성 쌍생아에서 IBD의 일치의 증가에 의해 입증된 바와 같이, 유전적 요인이 IBD 병인에 중요한 역할을 한다(S. Vermeire, P. Rutgeerts, Genes Immun 6, 637 (2005)). CD와 UC는 일부 유전적 감수성 유전자좌를 공유하지만 그 외에는 상이한 관련 장애로 생각된다.
따라서, CD 및/또는 UC를 포함하는, 그러나 이에 제한되지 않는, 염증성 장 질환에 대한 유전적 위험을 설명하고/하거나, 이에 대한 감수성 또는 방어를 진단하고/하거나 예측하는 것을 도울 수 있는 다른 유전자, 대립유전자 변이체 및/또는 하플로타입(haplotype)을 결정하는 것이 당 업계에 요구된다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD) 발병의 저확률 또는 고확률을 예측하는 방법으로서, 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및 위험 대립유전자가 검출될 때, 대상체에서 IBD 발병의 고확률을 예측하거나; 또는 위험 대립유전자가 검출되지 않을 때, 대상체에서 IBD 발병의 저확률을 예측하는 단계를 포함하는 방법을 제공한다.
다양한 실시양태에서, 유전자/유전자좌는 SLC26A4, DLG4, GIPR, ZHX3, TNRC6B, CDK6, PRR5L, WNT2B, LRRC16A, HIST1 클러스터[모든 히스톤 클러스터 1 유전자(all Histone cluster 1 genes)], GTF2IRD2B, ETS1, SLC5A1 또는 TET2, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), CDK6, LRRC16A, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 HIST1 클러스터(모든 히스톤 클러스터 1 유전자)를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 CDK6을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 LRRC16A를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 서열 번호 1 내지 서열 번호 341 중 하나 이상을 포함한다.
다양한 다른 실시양태에서, 대상체의 유전자형을 분석하는 단계는 대상체로부터 샘플을 수득하는 단계; 및 유전자/유전자좌에서 위험 대립유전자에 대해 샘플의 유전자형을 분석하는 단계를 포함한다. 또 다른 실시양태에서, 샘플의 유전자형을 분석하는 단계는 샘플을, 위험 대립유전자에 특이적인 올리고뉴클레오티드 프로브와 접촉시키는 단계; 올리고뉴클레오티드 프로브와 위험 대립유전자 사이에 대립유전자 특이적 혼성화 복합체를 생성하는 단계; 및 대립유전자 특이적 혼성화 복합체가 검출될 때, 위험 대립유전자를 검출하거나; 또는 대립유전자 특이적 혼성화 복합체가 검출되지 않을 때, 위험 대립유전자를 검출하지 않는 단계를 포함한다. 일부 실시양태에서, 올리고뉴클레오티드 프로브는 형광 염료로 표지되며, 대립유전자 특이적 혼성화 복합체를 검출하는 단계는 올리고뉴클레오티드 프로브로부터 형광 신호를 검출하는 단계를 포함한다. 다른 실시양태에서, 올리고뉴클레오티드 프로브는 리포터 염료 및 켄처 염료를 포함한다.
다양한 실시양태에서, 상기 방법은 대립유전자 특이적 혼성화 복합체를 형성한 후에 PCR 증폭을 수행하는 단계를 추가로 포함한다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD)을 진단하는 방법으로서, 유전자/유전자좌에서 위험 대립유전자에 대해 대상체로부터의 샘플의 유전자형을 분석하는 단계; 위험 대립유전자가 검출될 때, 대상체에서 IBD를 진단하는 단계; 및 IBD로 진단받은 대상체에게 IBD 요법을 실시함으로써, 대상체에서 IBD를 치료하는 단계를 포함하는 방법을 제공한다. 다양한 실시양태에서, 유전자/유전자좌는 SLC26A4, DLG4, GIPR, ZHX3, TNRC6B, CDK6, PRR5L, WNT2B, LRRC16A, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), GTF2IRD2B, ETS1, SLC5A1 또는 TET2, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), CDK6, LRRC16A, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 HIST1 클러스터(모든 히스톤 클러스터 1 유전자)를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 CDK6을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 LRRC16A를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 서열 번호 1 내지 서열 번호 341 중 하나 이상을 포함한다. 다양한 실시양태에서, 상기 방법은 대상체에게 IBD 요법을 제공하는 단계를 추가로 포함한다. 일부 실시양태에서, IBD 요법은 항-TNF 요법, 항-TL1A 요법, 결장 절제술, 또는 이들의 조합을 포함한다.
본 발명의 다양한 실시양태는 유전자/유전자좌에서 위험 대립유전자에 대해 대상체로부터 샘플의 유전자형을 분석하는 단계; 위험 대립유전자가 검출될 때, 대상체에서 IBD를 진단하는 단계; 및 IBD로 진단받은 대상체에게 IBD 요법을 실시함으로써, 대상체에서 IBD를 치료하는 단계를 포함하는 방법을 제공한다. 다양한 실시양태에서, 유전자/유전자좌는 SLC26A4, DLG4, GIPR, ZHX3, TNRC6B, CDK6, PRR5L, WNT2B, LRRC16A, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), GTF2IRD2B, ETS1, SLC5A1 또는 TET2, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), CDK6, LRRC16A, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 HIST1 클러스터(모든 히스톤 클러스터 1 유전자)를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 CDK6을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 LRRC16A를 포함한다. 다양한 다른 실시양태에서, 유전자/유전자좌는 서열 번호 1 내지 서열 번호 341 중 하나 이상을 포함한다. 다양한 실시양태에서, 상기 방법은 대상체에게 IBD 요법을 제공하는 단계를 추가로 포함한다. 일부 실시양태에서, IBD 요법은 항-TNF 요법, 항-TL1A 요법, 결장 절제술, 또는 이들의 조합을 포함한다.
본 발명의 다양한 실시양태는 병태와 관련된 유전자/유전자좌를 확인하는 방법으로서, 병태의 코호트의 샘플로부터 유전자 데이터를 취득하는 단계; 유전자 데이터에 대해 GLS 변환을 수행함으로써, 유전자 데이터를 비상관화하는(decorrelating) 단계; GLS 변환된 유전자 데이터에 대해 유전자 기반 분석을 수행하는 단계; 및 병태와 관련된 유전자/유전자좌를 확인하는 단계를 포함하는 방법을 제공한다. 다양한 실시양태에서, 병태는 IBD, CD 또는 UC, 또는 이들의 조합이다. 일부 실시양태에서, 코호트는 상관된 대상체 또는 가족 대상체를 포함한다. 다른 실시양태에서, 유전자 데이터는 SNP 유전자형을 포함한다. 또 다른 실시양태에서, GLS 변환을 수행하는 단계는, 함수 , , , , 또는 이들의 조합에 따라 유전자 데이터를 변환하는 단계를 포함한다.
다양한 실시양태에서, 유전자 기반 분석을 수행하는 단계는 독립적인 또는 비상관 대상체의 가정에 기초하여 유전자 기반 검사를 적용하는 단계를 포함한다. 다양한 실시양태에서, 유전자 기반 분석을 수행하는 단계는 C-알파 SKAT, SKAT-CommonRare, CMC, WSS, 가변 임계치, 또는 포괄적 접근법, 또는 이들의 조합을 적용하는 단계를 포함한다.
예시적인 실시양태를 참조된 도면에 도시한다. 본원에 개시된 실시양태 및 도면은 제한적인 것이라기보다는 예시적인 것으로 간주해야 한다.
도 1A∼도 1B는 본 발명의 다양한 실시양태에 따라서, 단일 SNP 기반 및 유전자 기반 분석을 도시한다.
도 2A∼도 2B는 본 발명의 다양한 실시양태에 따라서, 맨하탄(Manhattan) 플롯을 도시한다.
도 3은 본 발명의 다양한 실시양태에 따라서, 맨해튼 플롯을 도시하며: 조스틴(Jostin) 영역은 제외한다.
도 4는 본 발명의 다양한 실시양태에 따라서, 본 분석에서 확인된 신규 유전자/영역의 목록: SLC26A4, DLG4, GIPR, ZHX3, TNRC6B, CDK6, PRR5L, WNT2B, LRRC16A, HIST1 클러스터(모두 히스톤 클러스터 1 유전자), GTF2IRD2B, ETS1, SLC5A1 및 TET2를 도시한다.
도 5A∼도 5B는 본 발명의 다양한 실시양태에 따라서, (A) 비-IBD 영역과 비교하여 히스톤 마크에 존재할 가능성의 증가, (B) 알려진 IBD SNP와 비교하여 히스톤 마크에 존재할 가능성의 증가를 도시한다.
도 6A∼도 6D는 본 발명의 다양한 실시양태에 따라서, TET2 영역에 대한 상세한 조사 내용을 도시한다: 국소 플롯 (A), SNP (B), 미세 맵핑 (C), 및 기능 (D). rs17035289는 서열 번호 333이고 rs2726518은 서열 번호 334이다. 다른 모든 rs 번호는 표 1에 있다.
도 7A∼도 7C는 본 발명의 다양한 실시양태에 따라서, LRRC16 영역에 대한 상세한 조사 내용을 도시한다: 국소 플롯 (A), 국소 플롯 (B), 및 4개의 독립 신호로 미세 맵핑 (C).
도 8A∼8C는 본 발명의 다양한 실시양태에 따라서, eQTL 결과를 도시한다: SeeQTL (A), Scandb (B) 및 GeneVar (C). rs9358858은 서열 번호 335이다. 다른 모든 rs 번호는 표 1에 있다.
도 9A∼도 9C는 본 발명의 다양한 실시양태에 따라서, HIST1 클러스터의 제1부분에 대한 상세한 조사 내용을 도시한다: 유전자 (A), 국소 신호 (B), 및 3개의 독립 신호(P = 2.23E-25)로 미세 맵핑 (C). rs2071303은 서열 번호 336이고, rs13198474는 서열 번호 337이고, rs198846은 서열 번호 338이고, rs198854는 서열 번호 339이다.
도 10A∼도 10B는 본 발명의 다양한 실시양태에 따라서, eQTL 분석을 도시한다: SCANdb (A) 및 혈액 eQTL (B). rs13198474는 서열 번호 337이고, rs198846은 서열 번호 338이고 rs198854는 서열 번호 339이다.
도 11A∼도 11C는 본 발명의 다양한 실시양태에 따라서, HIST1 클러스터의 제2부분에 대한 상세한 조사 내용을 도시한다: 유전자 (A), 국소 신호 (B) 및 4개의 독립 신호(P = 3.25E-29)로 미세 맵핑 (C). rs9295740은 서열 번호 340이고 rs9461412는 서열 번호 341이다.
도 12는 본 발명의 다양한 실시양태에 따라서, eQTL 분석: SCANdb를 도시한다.
도 13은 본 발명의 다양한 실시양태들에 따라서, 3개의 영역: LRRC16, HIST1 클러스터 내의 제1부분, 및 HIST1 클러스터 내의 제2부분의 독립 신호들을 도시한다.
도 1A∼도 1B는 본 발명의 다양한 실시양태에 따라서, 단일 SNP 기반 및 유전자 기반 분석을 도시한다.
도 2A∼도 2B는 본 발명의 다양한 실시양태에 따라서, 맨하탄(Manhattan) 플롯을 도시한다.
도 3은 본 발명의 다양한 실시양태에 따라서, 맨해튼 플롯을 도시하며: 조스틴(Jostin) 영역은 제외한다.
도 4는 본 발명의 다양한 실시양태에 따라서, 본 분석에서 확인된 신규 유전자/영역의 목록: SLC26A4, DLG4, GIPR, ZHX3, TNRC6B, CDK6, PRR5L, WNT2B, LRRC16A, HIST1 클러스터(모두 히스톤 클러스터 1 유전자), GTF2IRD2B, ETS1, SLC5A1 및 TET2를 도시한다.
도 5A∼도 5B는 본 발명의 다양한 실시양태에 따라서, (A) 비-IBD 영역과 비교하여 히스톤 마크에 존재할 가능성의 증가, (B) 알려진 IBD SNP와 비교하여 히스톤 마크에 존재할 가능성의 증가를 도시한다.
도 6A∼도 6D는 본 발명의 다양한 실시양태에 따라서, TET2 영역에 대한 상세한 조사 내용을 도시한다: 국소 플롯 (A), SNP (B), 미세 맵핑 (C), 및 기능 (D). rs17035289는 서열 번호 333이고 rs2726518은 서열 번호 334이다. 다른 모든 rs 번호는 표 1에 있다.
도 7A∼도 7C는 본 발명의 다양한 실시양태에 따라서, LRRC16 영역에 대한 상세한 조사 내용을 도시한다: 국소 플롯 (A), 국소 플롯 (B), 및 4개의 독립 신호로 미세 맵핑 (C).
도 8A∼8C는 본 발명의 다양한 실시양태에 따라서, eQTL 결과를 도시한다: SeeQTL (A), Scandb (B) 및 GeneVar (C). rs9358858은 서열 번호 335이다. 다른 모든 rs 번호는 표 1에 있다.
도 9A∼도 9C는 본 발명의 다양한 실시양태에 따라서, HIST1 클러스터의 제1부분에 대한 상세한 조사 내용을 도시한다: 유전자 (A), 국소 신호 (B), 및 3개의 독립 신호(P = 2.23E-25)로 미세 맵핑 (C). rs2071303은 서열 번호 336이고, rs13198474는 서열 번호 337이고, rs198846은 서열 번호 338이고, rs198854는 서열 번호 339이다.
도 10A∼도 10B는 본 발명의 다양한 실시양태에 따라서, eQTL 분석을 도시한다: SCANdb (A) 및 혈액 eQTL (B). rs13198474는 서열 번호 337이고, rs198846은 서열 번호 338이고 rs198854는 서열 번호 339이다.
도 11A∼도 11C는 본 발명의 다양한 실시양태에 따라서, HIST1 클러스터의 제2부분에 대한 상세한 조사 내용을 도시한다: 유전자 (A), 국소 신호 (B) 및 4개의 독립 신호(P = 3.25E-29)로 미세 맵핑 (C). rs9295740은 서열 번호 340이고 rs9461412는 서열 번호 341이다.
도 12는 본 발명의 다양한 실시양태에 따라서, eQTL 분석: SCANdb를 도시한다.
도 13은 본 발명의 다양한 실시양태들에 따라서, 3개의 영역: LRRC16, HIST1 클러스터 내의 제1부분, 및 HIST1 클러스터 내의 제2부분의 독립 신호들을 도시한다.
본원에 인용된 모든 참고 문헌은 완전히 개시된 것처럼 그 전문이 참고로 포함된다. 달리 정의되지 않는 한, 본원에서 사용되는 기술 및 과학 용어는 본 발명이 속하는 기술 분야의 당업자에 의해 일반적으로 이해되는 바와 동일한 의미를 갖는다. 문헌[Allen et al., Remington: The Science and Practice of Pharmacy 22 nd ed., Pharmaceutical Press (September 15, 2012); Hornyak et al., Introduction to Nanoscience and Nanotechnology, CRC Press (2008); Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology 3 rd ed., revised ed., J. Wiley & Sons (New York, NY 2006); Smith, March's Advanced Organic Chemistry Reactions, Mechanisms and Structure 7 th ed., J. Wiley & Sons (New York, NY 2013); Singleton, Dictionary of DNA and Genome Technology 3 rd ed., Wiley-Blackwell (November 28, 2012); 및 Green and Sambrook, Molecular Cloning: A Laboratory Manual 4th ed., Cold Spring Harbor Laboratory Press (Cold Spring Harbor, NY 2012)]은 당업자에게 본 출원에서 사용된 다수의 용어에 대한 일반적인 지침을 제공한다. 항체를 제조 방법에 대한 참고로, 문헌[Greenfield, Antibodies A Laboratory Manual 2 nd ed., Cold Spring Harbor Press (Cold Spring Harbor NY, 2013); Khler and Milstein, Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion, Eur. J. Immunol. 1976 Jul, 6(7):511-9; Queen and Selick, Humanized immunoglobulins, 미국 특허 제5,585,089호(1996년 12월); 및 Riechmann et al., Reshaping human antibodies for therapy, Nature 1988 Mar 24, 332(6162):323-7]을 참조한다.
당업자는 본 발명의 실시에 사용될 수 있는, 본원에 기재된 것과 유사한 또는 동등한 많은 방법 및 재료를 인식할 것이다. 본 발명의 다른 특징 및 이점은, 본 발명의 실시양태의 다양한 특징을 예로써 도시하는 수반된 도면과 함께 주어진 하기의 상세한 설명으로부터 명백해질 것이다. 실제로, 본 발명은 결코 기재된 방법 및 재료에 제한되지 않는다. 편의상, 본 명세서, 실시예 및 첨부된 청구 범위에서, 본원에 사용되는 특정 용어는 여기에 정리된다.
달리 언급되지 않거나 문맥에 내포되지 않는 한, 다음의 용어 및 문구는 아래에 제공된 의미를 포함한다. 달리 명백하게 언급되지 않거나 문맥에서 명백하지 않는 한, 용어 및 문구는 해당 용어 또는 문구가 관련 기술 분야에서 취득한 의미를 배제하지 않는다. 달리 정의되지 않는 한, 본원에서 사용되는 모든 기술 및 과학 용어는 본 발명이 속하는 기술 분야의 당업자에 의해 일반적으로 이해되는 바와 동일한 의미를 나타낸다. 본 발명은 본원에 기재된 특정 방법, 프로토콜 및 시약 등에 제한되지 않고 다양할 수 있음을 알아야 한다. 발명의 범위는 청구 범위에 의해서만 제한되기 때문에, 본원에 사용된 정의 및 용어는 특정 실시양태를 설명하는 것을 돕기 위해 제공되며, 청구된 발명을 제한하고자 하는 것은 아니다.
본원에 사용된 바와 같이, 용어 "포함하는" 또는 "포함한다"는 실시양태에 유용하지만, 유용성 여부와 상관없이 불특정 요소의 포함에 개방된 조성물, 방법 및 이들의 각각의 성분(들)과 관련하여 사용된다. 일반적으로, 본원에서 사용된 용어는 일반적으로 "개방" 용어로 의도됨을 당업자는 이해할 것이다(예를 들어, 용어 "포함하는"은 "포함하지만 이에 제한되지 않는"으로 해석되어야 하고, "갖는"은 "적어도 갖는"으로 해석되어야 하고, 용어 "포함한다"는 "포함하지만 이에 제한되지 않는다" 등으로 해석되어야 함). 용어의 동의어, 예를 들어 포함하는, 함유하는 또는 갖는으로서 개방적인 용어 "포함하는"은 본 발명을 기재하고 청구하기 위해 본 명세서에서 사용되지만, 본 발명 또는 그 실시양태는 대안적으로 "로 이루어진" 또는 "∼로 본질적으로 이루어진"과 같은 대안적인 용어를 사용하여 기재될 수 있다.
달리 언급되지 않는 한, 본 출원의 (특히 청구항의 문맥에서) 특정 실시양태를 기재하는 문맥에서 사용되는 용어 "하나"("a"및 "an" 및 "the") 및 유사한 언급 대상은 단수 및 복수 모두를 포함하는 것으로 해석될 수 있다. 본원에서 값의 범위의 나열은 단지 그 범위 내에 속하는 각각의 개별 값을 개별적으로 언급하는 단축된 방법으로서 제공하기 위한 것이다. 본원에서 달리 지시하지 않는 한, 각각의 개별 값은 본원에서 개별적으로 나열된 것처럼 명세서에 포함된다. 본원에 기재된 모든 방법은 본원에서 달리 지시되지 않는 한 또는 달리 문맥에 명백하게 반박되지 않는다면 임의의 적합한 순서로 수행될 수 있다. 본원에서 특정 실시양태와 관련하여 제공되는 모든 예, 예시적인 언어(예를 들어, "와 같은")의 사용은 단지 본 출원을 더 분명히 하도록 의도된 것이며, 달리 청구되는 본 출원의 범위를 제한하지 않는다. 약어 "e.g.(예를 들어)"는 라틴어 exempli gratia에서 파생되었으며, 본원에서 비제한적인 예를 나타내기 위해 사용된다. 따라서, 약어 "e.g."는 용어 "예를 들어"와 동의어이다. 명세서에서 어떠한 언어도 출원의 실행에 필수적인 청구되지 않은 어떤 요소를 나타내는 것으로 해석되어서는 안 된다.
본원에서 사용된 바와 같이, 질병, 장애 또는 의학적 상태와 관련하여 사용될 때 용어 "치료하다", "치료", "치료하는" 또는 "개선하는"은 치료 조치 및 예방 또는 방지 조치 모두를 지칭하며, 그 목적은 증상 또는 병태의 진행 또는 중증도를 예방, 역전, 완화, 개선, 억제, 감소, 지연 또는 중지하는 것이다. 용어 "치료하는 것"은 적어도 병태의 적어도 하나의 부작용 또는 증상을 감소시키거나 완화하는 것을 포함한다. 치료는 일반적으로 하나 이상의 증상 또는 임상 지표가 감소될 경우 "효과적"이다. 또는 질병, 장애 또는 의학적 상태의 진행이 감소되거나 중단되는 경우 치료는 "효과적"이다. 즉, "치료"는 증상이나 지표의 개선뿐 아니라 치료가 없을 때 예상되는 증상의 진행 또는 악화의 중지 또는 적어도 지연을 포함한다. 또한 "치료"는 유익한 결과를 추구하거나 얻는 것을 의미할 수 있거나, 치료가 궁극적으로 성공적이지 못할 경우에도 개인의 발병 가능성을 낮출 수 있다. 치료가 필요한 사람들은 이미 병태가 있는 사람뿐만 아니라 병태에 걸리기 쉬운 사람 또는 병태가 예방되어야 하는 사람을 포함한다.
"유익한 결과" 또는 "바람직한 결과"는 질병 상태의 중증도를 감소시키거나 완화하고, 질병 상태의 악화를 방지하고, 질병 상태를 치료하고, 질병 상태의 발생을 방지하고, 환자의 질병 상태의 발생 가능성을 낮추고, 이환율과 사망률을 감소시키고, 환자의 수명이나 기대 수명을 연장하는 것을 포함할 수 있으나 이들에 결코 제한되지 않는다. 비제한적인 예로서, "유익한 결과" 또는 "바람직한 결과"는 하나 이상의 증상(들)의 완화, 장애 범위의 감소, 장 염증 및/또는 섬유증의 안정화된 상태(즉, 악화되지 않는 상태), 장 염증 및/또는 섬유증의 지체 또는 지연, 및 장 염증 및/또는 섬유증과 관련된 증상의 개선 또는 경감을 포함한다.
본원에서 사용된 바와 같이, "질병", "병태" 및 "질병 상태"는 임의 형태의 장 염증 또는 장 염증 관련 병태, 질병 또는 장애, 예를 들어, 장 염증, 장 섬유증, 염증성 장 질환(IBD), 크론병(CD), 궤양성 대장염(UC), 대장염, 급성 대장염 및 만성 대장염을 포함할 수 있으나 이들에 결코 제한되지는 않는다.
대상체에서 염증성 장 질환(IBD) 발병의 저확률 또는 고확률을 예측하는 방법으로서, 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및 위험 대립유전자가 검출될 때, 대상체에서 IBD 발병의 고확률을 예측하거나; 또는 위험 대립유전자가 검출되지 않을 때, 대상체에서 IBD 발병의 저확률을 예측하는 단계를 포함하는 방법을 제공한다.
본원에서 사용된 바와 같이, "위험 변이체"는 대립유전자로서, 그 존재가 위험 변이체가 없는 개체에 비해 크론병 및 궤양성 대장염을 포함하는, 그러나 이에 제한되지 않는, 염증성 장 질환에 대한 감수성의 증가와 관련된 대립유전자를 지칭한다.
본원에서 사용된 바와 같이, "고확률"은 위험 변이체가 없는 개체에 비해 위험 변이체가 개체에 존재할 때 염증성 장 질환에 대한 감수성의 증가를 의미한다.
본원에서 사용된 바와 같이, "저확률"은 위험 변이체가 있는 개체에 비해 위험 변이체가 개체에 존재하지 않을 때 염증성 장 질환에 대한 감수성의 감소를 의미한다.
본원에서 사용된 바와 같이, 용어 "투여"는 원하는 부위에서 제제의 적어도 부분적인 국소화를 유도하는 방법 또는 경로에 의해 대상체에게 본원에 개시된 바와 같은 제제의 배치를 의미한다. "투여 경로"는 에어로졸, 코, 경구, 경점막, 경피, 비경구, 장, 국소(topical 또는 local)를 포함하는, 그러나 이에 제한되지 않는, 당 업계에 공지된 임의의 투여 경로를 지칭할 수 있다. "비경구"는 두개 내, 뇌실 내, 척수강 내, 경막 외, 경막 내, 안와 내, 주입, 동맥 내, 관절낭 내, 심장 내, 피 내, 근육 내, 복강 내, 폐 내, 척수 내, 흉골 내, 척수강 내, 자궁 내, 정맥 내, 지주막하, 피막 하, 피하, 경점막 또는 경기관을 포함하는 일반적으로 주사와 관련된 투여 경로를 나타낸다. 비경구 경로를 통해, 조성물은 주입 또는 주사용 용액 또는 현탁액, 또는 동결 건조된 분말 형태일 수 있다. 장관 경로를 통해, 약학 조성물은 정제, 겔 캡슐, 당의정, 시럽, 현탁액, 용액, 분말, 과립제, 에멀젼, 제어 방출을 허용하는 마이크로스피어 또는 나노스피어 또는 지질 소포 또는 중합체 소포의 형태 일 수 있다. 국소(topical) 경로를 통해, 약학 조성물은 에어로졸, 로션, 크림, 겔, 연고, 현탁액, 용액 또는 유화액의 형태일 수 있다. 본 발명에 따르면, "투여"는 자가 투여일 수 있다. 예를 들어, 대상체가 본원에 개시된 조성물을 소비하는 것을 "투여"로 간주한다.
본원에 사용된 바와 같이 용어 "샘플" 또는 "생물학적 샘플"은 생물학적 유기체로부터 취하거나 단리된 샘플, 예를 들어 대상체로부터의 혈액을 나타낸다. 예시적인 생물학적 샘플은 뺨 도말; 점액; 전혈, 혈액, 혈청; 혈장; 소변; 타액; 정액; 림프; 분변 추출물; 가래; 다른 체액 또는 생체액; 세포 샘플; 및/또는 조직 샘플 등을 포함하나 이에 제한되지 않는다. 용어는 또한 상기 언급된 샘플의 혼합물을 포함한다. 용어 "샘플"은 또한 미처리 또는 전처리(또는 사전 처리된) 생물학적 샘플을 포함한다. 일부 실시양태에서, 샘플은 개체로부터의 하나 이상의 세포를 포함할 수 있다.
본원에 사용된 바와 같이, "대상체"는 인간 또는 동물을 의미한다. 보통 동물은 영장류, 설치류, 가축 또는 사냥 동물과 같은 척추동물이다. 영장류는 침팬지, 시노몰로구스(cynomologous) 원숭이, 거미 원숭이, 및 마카크, 예를 들어 레수스(Rhesus)를 포함한다. 설치류는 마우스, 래트, 우드척, 패럿, 토끼 및 햄스터를 포함한다. 가축 및 사냥 동물은 소, 말, 돼지, 사슴, 들소, 버팔로, 고양잇과 종, 예를 들어 애완용 고양이 및 개과 종, 예를 들어 개, 여우, 늑대를 포함한다. 용어 "환자", "개체" 및 "대상체" 본원에서 호환적으로 사용된다. 한 실시양태에서, 대상체는 포유동물이다. 포유동물은 인간, 비인간 영장류, 마우스, 래트, 개, 고양이, 말 또는 소일 수 있지만, 이들 예에 제한되는 것은 아니다. 또한, 본원에 기재된 방법은 가축 및/또는 애완동물을 치료하는 데 사용될 수 있다.
본원에 사용된 바와 같이, "포유동물"은 제한 없이 인간 및 비인간 영장류, 예를 들어 침팬지 및 다른 유인원 및 원숭이 종; 소, 양, 돼지, 염소 및 말과 같은 사육 동물; 개와 고양이와 같은 가축; 마우스, 래트 및 기니피그와 같은 설치류를 포함한 실험실 동물 등을 포함하는 포유류의 임의의 구성원을 지칭한다. 이 용어는 특정 연령이나 성별을 나타내지 않는다. 따라서 성인과 신생아 대상체뿐만 아니라 태아도, 남성인지 여성인지에 관계없이 이 용어의 범위에 포함되는 것으로 의도된다.
대상체는 치료가 필요한 병태(예를 들어, 장 염증 및/또는 섬유증, IBD, CD, UC, 대장염, 급성 대장염 및 만성 대장염) 또는 병태와 관련된 하나 이상의 합병증 으로 이전에 진단받았거나 또는 이들에 걸리거나 이들을 가진 것으로 확인된 자, 경우에 따라 병태 또는 병태와 관련된 하나 이상의 합병증의 치료를 이미 받은 자일 수 있다. 대안적으로, 대상체는 또한 병태 또는 병태와 관련된 하나 이상의 합병증을 가진 것으로 이전에 진단받은 적이 없는 자일 수 있다. 예를 들어, 대상체는 병태 또는 병태와 관련된 하나 이상의 합병증에 대해 하나 이상의 위험 인자를 나타내는 대상체 또는 위험 인자를 나타내지 않는 대상체일 수 있다. 특정 병태에 대한 치료가 "필요한 대상체"는 그 병태를 가진 것으로 의심되는 대상체, 그 병태를 가지고 있다고 진단받은 대상체, 그 병태에 대해 이미 치료를 받거나 받고 있는 대상체, 그 병태에 대해 치료받지 않은 대상체, 또는 그 병태의 발생 위험에 있는 대상체일 수 있다.
용어 "통계적으로 유의하다" 또는 "유의하게"는 차이가 있다는 통계적 증거를 의미한다. 이는 귀무가설이 실제로 참일 때 귀무가설을 기각하기로 결정할 확률로 정의된다. 결정은 종종 p 값을 사용하여 이루어진다.
본원에서 사용된 바와 같이, 특정 집단에서 "질병의 오즈"는 그러한 집단에서의 질병 확률과 비질병 확률 사이의 비율로서 정의된다(즉, 질병의 오즈 = 질병 확률/비질병 확률).
본원에서 사용된 바와 같이, 질병과 관련하여 "위험 대립유전자의 오즈비(OR: Odds Ratio)"는 위험 대립유전자의 보유 집단에서의 질병의 오즈와 위험 대립유전자의 비보유 집단에서의 질병의 오즈 사이의 비율로서 정의된다(즉, 위험 대립유전자의 OR = 보유자에서의 질병의 오즈/비보유자에서의 질병의 오즈).
본 발명의 방법
본 발명은 IBD와 같은 병태와 관련된 유전자/유전자좌를 확인하는 방법을 제공한다. 이들 유전자/유전자좌의 확인은 IBD와 관련하여 집단의 위험 계층화에 사용될 수 있다. 본 발명자들은 출생시 상기 도구를 사용하여 환경 후생 유전 인자를 조절할 수 있는 예방적 중재를 제공함으로써 집단에 영향을 줄 목적으로 IBD의 위험이 있는 사람들을 확인할 수 있다. 본 발명은 또한 IBD를 진단하는 방법 및 정밀 의학 접근법으로서 IBD 치료 계획을 개별화하는 방법을 제공한다.
예측
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD) 발병의 저확률 또는 고확률을 예측하는 방법으로서, 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및 위험 대립유전자가 검출될 때, 대상체에서 IBD 발병의 고확률을 예측하는 단계; 또는 위험 대립유전자가 검출되지 않을 때, 대상체에서 IBD 발병의 저확률을 예측하는 단계를 포함하는 방법을 제공한다.
다양한 실시양태에서, 유전자/유전자좌는 SLC26A4, DLG4, GIPR, ZHX3, TNRC6B, CDK6, PRR5L, WNT2B, LRRC16A, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), GTF2IRD2B, ETS1, SLC5A1 또는 TET2, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), CDK6, LRRC16A, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 HIST1 클러스터(모든 히스톤 클러스터 1 유전자)를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 CDK6을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 LRRC16A를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 서열 번호 1 내지 서열 번호 341 중 하나 이상을 포함한다.
다양한 다른 실시양태에서, 대상체의 유전자형을 분석하는 단계는 대상체로부터 샘플을 수득하는 단계; 및 유전자/유전자좌에서 위험 대립유전자에 대해 샘플의 유전자형을 분석하는 단계를 포함한다. 또 다른 실시양태에서, 샘플의 유전자형을 분석하는 단계는 샘플을, 위험 대립유전자에 특이적인 올리고뉴클레오티드 프로브와 접촉시키는 단계; 올리고뉴클레오티드 프로브와 위험 대립유전자 사이에 대립유전자 특이적 혼성화 복합체를 생성하는 단계; 및 대립유전자 특이적 혼성화 복합체가 검출될 때, 위험 대립유전자를 검출하거나; 또는 대립유전자 특이적 혼성화 복합체가 검출되지 않을 때, 위험 대립유전자를 검출하지 않는 단계를 포함한다. 일부 실시양태에서, 올리고뉴클레오티드 프로브는 형광 염료로 표지되며, 대립유전자 특이적 혼성화 복합체를 검출하는 단계는 올리고뉴클레오티드 프로브로부터 형광 신호를 검출하는 단계를 포함한다. 다른 실시양태에서, 올리고뉴클레오티드 프로브는 리포터 염료 및 켄처 염료를 포함한다.
다양한 실시양태에서, 상기 방법은 대립유전자 특이적 혼성화 복합체를 형성한 후에 PCR 증폭을 수행하는 단계를 추가로 포함한다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD) 발병의 저확률 또는 고확률을 예측하는 방법을 제공한다. 상기 방법은 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및 위험 대립유전자가 검출될 때, 대상체에서 IBD 발병의 고확률을 예측하거나; 또는 위험 대립유전자가 검출되지 않을 때, 대상체에서 IBD 발병의 저확률을 예측하는 단계를 포함한다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD) 발병의 고확률을 예측하는 방법을 제공한다. 상기 방법은 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및 위험 대립유전자가 검출될 때, 대상체에서 IBD 발병의 고확률을 예측하는 단계를 포함한다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD) 발병의 저확률을 예측하는 방법을 제공한다. 상기 방법은 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및 위험 대립유전자가 검출되지 않을 때, 대상체에서 IBD 발병의 저확률을 예측하는 단계를 포함한다.
본 발명에 따르면, IBD 발병의 저확률 또는 고확률은 대상체가 속한 일반 집단과 비교하여 대상체가 더 크거나 적은 IBD의 발병 가능성을 갖는다는 것을 의미한다.
진단
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD)을 진단하는 방법으로서, 유전자/유전자좌에서 위험 대립유전자에 대해 대상체로부터의 샘플의 유전자형을 분석하는 단계; 위험 대립유전자가 검출될 때, 대상체에서 IBD를 진단하는 단계; 및 IBD로 진단받은 대상체에게 IBD 요법을 실시함으로써, 대상체에서 IBD를 치료하는 단계를 포함하는 방법을 제공한다. 다양한 실시양태에서, 유전자/유전자좌는 SLC26A4, DLG4, GIPR, ZHX3, TNRC6B, CDK6, PRR5L, WNT2B, LRRC16A, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), GTF2IRD2B, ETS1, SLC5A1 또는 TET2, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), CDK6, LRRC16A, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 HIST1 클러스터(모든 히스톤 클러스터 1 유전자)를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 CDK6을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 LRRC16A를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 서열 번호 1 내지 서열 번호 341 중 하나 이상을 포함한다. 일부 실시양태에서, IBD 요법은 항-TNF 요법, 항-TL1A 요법, 결장 절제술, 또는 이들의 조합을 포함한다.
본 발명의 다양한 실시양태는 유전자/유전자좌에서 위험 대립유전자에 대해 대상체로부터 샘플의 유전자형을 분석하는 단계; 위험 대립유전자가 검출될 때, 대상체에서 IBD를 진단하는 단계; 및 IBD로 진단받은 대상체에게 IBD 요법을 실시함으로써, 대상체에서 IBD를 치료하는 단계를 포함하는 방법을 제공한다. 다양한 실시양태에서, 유전자/유전자좌는 SLC26A4, DLG4, GIPR, ZHX3, TNRC6B, CDK6, PRR5L, WNT2B, LRRC16A, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), GTF2IRD2B, ETS1, SLC5A1 또는 TET2, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), CDK6, LRRC16A, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 HIST1 클러스터(모든 히스톤 클러스터 1 유전자)를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 CDK6을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 LRRC16A를 포함한다. 다양한 다른 실시양태에서, 유전자/유전자좌는 서열 번호 1 내지 서열 번호 341 중 하나 이상을 포함한다. 다양한 실시양태에서, 상기 방법은 대상체에게 IBD 요법을 제공하는 단계를 추가로 포함한다. 일부 실시양태에서, IBD 요법은 항-TNF 요법, 항-TL1A 요법, 결장 절제술, 또는 이들의 조합을 포함한다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD)에 대한 감수성을 확인하거나 또는 이에 대한 방어를 확인하는 방법을 제공한다. 상기 방법은 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및 위험 대립유전자가 검출될 때, 대상체에서 IBD에 대한 감수성을 확인하거나 단계; 또는 위험 대립유전자가 검출되지 않을 때, 대상체에서 IBD에 대한 방어를 확인하는 단계를 포함한다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD)에 대한 감수성을 확인하는 방법을 제공한다. 상기 방법은 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및 위험 대립유전자가 검출될 때, 대상체에서 IBD에 대한 감수성을 확인하는 단계를 포함한다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD)에 대한 방어를 확인하는 방법을 제공한다. 상기 방법은 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및 위험 대립유전자가 검출되지 않을 때, 대상체에서 IBD에 대한 방어를 확인하는 단계를 포함한다.
본 발명에 따르면, IBD에 대한 감수성은 대상체가 속하는 일반 집단에 비해 대상체가 더 큰 IBD의 발병 가능성을 갖는다는 것을 의미한다. 본 발명에 따르면, IBD에 대한 방어는 대상체가 속하는 일반 집단과 비교하여 대상체가 더 적은 IBD의 발병 가능성을 갖는다는 것을 의미한다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD)을 진단하는 방법을 제공한다. 상기 방법은 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및 위험 대립유전자가 검출될 때, 대상체에서 IBD를 진단하거나; 또는 위험 대립유전자가 검출되지 않을 때, 대상체에서 IBD를 진단하지 않는 단계를 포함한다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD)을 진단하는 방법을 제공한다. 상기 방법은 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 위험 대립유전자를 검출하는 단계; 및 대상체에서 IBD를 진단하는 단계를 포함한다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD)을 치료하는 방법을 제공한다. 상기 방법은 본원에 기재된 방법에 따라 IBD로 진단받은 대상체에게 IBD 요법을 실시함으로써, 대상체에서 IBD를 치료하는 단계를 포함한다. 다양한 실시양태에서, 상기 방법은 대상체에게 IBD 요법을 제공하는 단계를 추가로 포함한다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD)을 치료하는 방법을 제공한다. 상기 방법은 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및 위험 대립유전자가 검출될 때, 대상체에게 IBD 요법을 실시하거나; 또는 위험 대립유전자가 검출되지 않을 때, 대상체에게 IBD 요법을 실시하지 않는 단계를 포함한다. 다양한 실시양태에서, 상기 방법은 대상체에게 IBD 요법을 제공하는 단계를 추가로 포함한다.
본 발명의 다양한 실시양태는 대상체에서 염증성 장 질환(IBD)을 치료하는 방법을 제공한다. 상기 방법은 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 위험 대립유전자를 검출하는 단계; 및 IBD 요법을 대상체에게 투여함으로써, 대상체에서 IBD를 치료하는 단계를 포함한다. 다양한 실시양태에서, 상기 방법은 대상체에게 IBD 요법을 제공하는 단계를 추가로 포함한다.
본 발명의 다양한 실시양태는 대상체에게 염증성 장 질환(IBD) 요법을 실시하는 방법을 제공한다. 상기 방법은 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및 위험 대립유전자가 검출될 때, 대상체에게 IBD 요법을 실시하거나; 또는 위험 대립유전자가 검출되지 않을 때, 대상체에게 IBD 요법을 실시하지 않는 단계를 포함한다.
본 발명의 다양한 실시양태는 대상체에게 염증성 장 질환(IBD) 요법을 실시하는 방법을 제공한다. 상기 방법은 유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 위험 대립유전자를 검출하는 단계; 및 대상체에게 IBD 요법을 실시하는 단계를 포함한다.
다양한 실시양태에서, IBD 요법은 항-TNF 요법, 항-TL1A 요법, 또는 결장 절제술, 또는 이들의 조합을 포함한다. 일부 실시양태에서, IBD 요법은 항-TNF 항체이다. 일부 실시양태에서, IBD 요법은 항-TL1A 항체이다. 일부 실시양태에서, IBD 요법은 결장 절제술이다.
다양한 실시양태에서, 대상체는 인간이다. 일부 실시양태에서, 대상체는 소아이다. 일부 실시양태에서, 대상체는 청소년이다. 다른 실시양태에서, 대상체는 성인이다. 다양한 실시양태에서, IBD는 크론병(CD) 또는 궤양성 대장염(UC)이다.
다양한 실시양태에서, 샘플은 뺨 도말; 점액; 전혈; 혈액; 혈청; 혈장; 소변; 타액; 정액; 림프; 분변 추출물; 가래; 다른 체액 또는 생체액; 세포 샘플; 또는 조직 샘플; 또는 이들의 조합이다. 다양한 실시양태에서, 샘플은 개체로부터의 핵산을 포함한다. 일부 실시양태에서, 핵산은 게놈 DNA를 포함한다. 다양한 실시양태에서, 샘플은 체액이다. 일부 실시양태에서, 체액은 전혈, 혈장, 타액, 점액 또는 뺨 도말이다. 다양한 실시양태에서, 샘플은 세포 또는 조직이다. 일부 실시양태에서, 세포는 혈액 세포이다. 일부 실시양태에서, 세포는 대상체로부터 수득되고 엡스타인 바 바이러스(Epstein Barr virus)로 형질전환된 혈액 세포주(예를 들어, 림프모구성 세포주)이다.
다양한 실시양태에서, 유전자/유전자좌는 표 1에 서열 번호 1 내지 341로서 열거된 유전자/유전자좌 중 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14개 이상 또는 모두를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 SLC26A4, DLG4, GIPR, ZHX3, TNRC6B, CDK6, PRR5L, WNT2B, LRRC16A, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), GTF2IRD2B, ETS1, SLC5A1 또는 TET2, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), CDK6, LRRC16A, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 HIST1 클러스터(모든 히스톤 클러스터 1 유전자)를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 CDK6을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 LRRC16A를 포함한다. 각각의 유전자는 하기 서열을 포함할 수 있다: SLC26A4 (서열 번호 1-6); DLG4 (서열 번호 7); GIPR (서열 번호 8-27); ZHX3 (서열 번호 28-30); TNRC6B (서열 번호 31-38); CDK6 (서열 번호 39-40); PRR5L (서열 번호 41-54); WNT2B (서열 번호 55-58); LRRC16A (서열 번호 59-75, 335); HIST1 클러스터(모든 히스톤 클러스터 1 유전자 - 서열 번호 76-173, 338, 339); GTF2IRD2B (서열 번호 174-180); ETS1 (서열 번호 181-325); SLC5A1 (서열 번호 326-327); 및 TET2 (서열 번호 328-332, 334).
다양한 실시양태에서, 위험 대립유전자는 표 1에 서열 번호 1 내지 341로서 열거된 위험 대립유전자 중 1, 2, 3, 4, 5, 6, 7, 8, 9, 10개 이상 또는 모두를 포함한다. 다양한 실시양태에서, 위험 대립유전자는 표 1에 서열 번호 1 내지 341로서 열거된 위험 대립유전자 중 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 99, 또는 100개 이상 또는 모두를 포함한다. 다양한 실시양태에서, 위험 대립유전자는 표 1에 서열 번호 1 내지 341로서 열거된 N개의 위험 대립유전자를 포함하며, N은 341 이하의 양의 정수(즉, 1≤N≤341)이다. 다양한 실시양태에서, 위험 대립유전자는 표 1에 서열 번호 1 내지 341로서 열거된 1-5, 5-10, 10-15, 15-20, 20-25, 25-30, 30-35, 35-40, 40-45, 45-50, 50-55, 55-60, 60-65, 65-70, 70-75, 75-80, 80-85, 85-90, 90-95, 또는 95-100개의 위험 대립유전자를 포함한다. 다양한 실시양태에서, 위험 대립유전자는 표 1에 서열 번호 1 내지 341로서 열거된 100-105, 105-110, 110-115, 115-120, 120-125, 125-130, 130-135, 135-140, 140-145, 145-150, 150-155, 155-160, 160-165, 165-170, 170-175, 175-180, 180-185, 185-190, 190-195, 또는 195-200개의 위험 대립유전자를 포함한다. 다양한 실시양태에서, 위험 대립유전자는 표 1에 서열 번호 1 내지 341로서 열거된 200-205, 205-210, 210-215, 215-220, 220-225, 325-230, 230-235, 235-240, 240-245, 245-250, 250-255, 255-260, 260-265, 265-270, 270-275, 275-280, 280-285, 285-290, 290-295, 또는 295-300개의 위험 대립유전자를 포함한다. 다양한 실시양태에서, 위험 대립유전자는 표 1에 서열 번호 1 내지 341로서 열거된 300-305, 305-310, 310-315, 315-320, 320-325, 325-330, 또는 330-341개의 위험 대립유전자를 포함한다.
일부 실시양태에서, 대상체의 유전자형은 대상체에 대해 수행된 이전의 유전자 또는 게놈 검사로부터 수득할 수 있고, 이들 이전의 검사는 특별히 IBD 또는 임의의 병태와 관련하여 수행되지 않았다. 예를 들어, 대상체의 유전자형은 대상체의 게놈 서열분석 결과를 분석하여 수득할 수 있거나 대상체의 개인 유전자 또는 게놈 정보를 저장하는 데이터베이스로부터 수득할 수 있다. 이들 실시양태에서, 대상체의 유전자형을 분석하는 단계는 이미 이용 가능한 데이터를 취득하고 분석하는 단계를 수반하기 때문에 대상체에 대해 검사실 검사를 수행할 필요가 없다. 다른 실시양태에서, 예를 들어, 개인 유전자 또는 게놈 정보가 이용 가능하지 않거나 대상체 또는 의사가 새로운 검사실 검사를 원할 때, 대상체의 유전자형을 분석하는 단계는 대상체에 대한 검사실 검사를 수행하는 단계를 요구한다.
본 발명의 다양한 실시양태에서, 대상체의 유전자형을 분석하는 단계는 대상체로부터 샘플을 수득하는 단계; 및 유전자/유전자좌에서 위험 대립유전자에 대해 샘플의 유전자형을 분석하는 단계를 포함한다.
일부 실시양태에서, 샘플의 유전자형을 분석하는 단계는 샘플을, 위험 대립유전자에 특이적인 올리고뉴클레오티드 프로브와 접촉시키는 단계; 올리고뉴클레오티드 프로브와 위험 대립유전자 사이에 대립유전자 특이적 혼성화 복합체를 생성하는 단계; 및 대립유전자 특이적 혼성화 복합체가 검출될 때, 위험 대립유전자를 검출하거나; 또는 대립유전자 특이적 혼성화 복합체가 검출되지 않을 때, 위험 대립유전자를 검출하지 않는 단계를 포함한다. 다양한 실시양태에서, 올리고뉴클레오티드 프로브는 형광 염료로 표지되며, 대립유전자 특이적 혼성화 복합체를 검출하는 단계는 올리고뉴클레오티드 프로브로부터 형광 신호를 검출하는 단계를 포함한다. 다양한 실시양태에서, 올리고뉴클레오티드 프로브는 리포터 염료 및 켄처 염료를 포함한다. 특정 실시양태에서, 상기 방법은 대립유전자 특이적 혼성화 복합체를 형성한 후에 PCR 증폭을 수행하는 단계를 추가로 포함한다. 다양한 실시양태에서, 대립유전자 특이적 혼성화 복합체를 검출하는 단계는 대립유전자 특이적 혼성화 복합체의 전기영동 이동성을 검출하는 단계를 포함한다.
다양한 실시양태에서, 샘플의 유전자형을 분석하는 단계는 SNP의 대립유전자에 특이적으로 결합하는 검출 제제와 샘플을 접촉시키는 단계; 및 검출 제제와 SNP의 대립유전자 사이의 결합 수준을 검출하는 단계에 의해 샘플에서 SNP의 대립유전자를 검출하는 단계를 포함한다. 대립유전자는 유전자형 분석, PCR, 역전사 PCR, 실시간 PCR, 마이크로어레이, DNA 서열분석 및 RNA 서열분석 기술에 의해 검출될 수 있다.
본 발명의 다양한 실시양태는 조성물을 제공한다. 다양한 실시양태에서, 조성물은 하나 이상의 유전자/유전자좌에서 하나 이상의 대립유전자에 특이적으로 결합하는 하나 이상의 검출 제제를 포함한다. 이 조성물은 병태와 관련된 유전자/유전자좌를 확인하고/하거나, IBD 발병의 저확률 또는 고확률을 예측하고/하거나, IBD에 대한 감수성 또는 방어를 예측하고/하거나, IBD를 진단하고/하거나, IBD를 치료하고/하거나, IBD 요법의 수행을 지시하는데 사용될 수 있다.
다양한 실시양태에서, 검출 제제는 올리고뉴클레오티드 프로브, 핵산, DNA, RNA, 앱타머, 펩티드, 단백질, 항체, 아비머 또는 소분자, 또는 이들의 조합이다. 일부 실시양태에서, 검출 제제는 SNP의 대립유전자를 표적화하는 대립 유전자 특이적 올리고뉴클레오티드 프로브이다. 다양한 실시양태에서, SNP의 대립유전자는 마이크로어레이를 사용하여 검출된다. 일부 실시양태에서, 마이크로어레이는 올리고뉴클레오티드 마이크로어레이, DNA 마이크로어레이, cDNA 마이크로어레이, RNA 마이크로어레이, 펩티드 마이크로어레이, 단백질 마이크로어레이 또는 항체 마이크로어레이, 또는 이들의 조합이다.
다양한 실시양태에서, SNP의 대립유전자를 검출하는 단계는 SNP의 대립유전자를 표적화하는 하나 이상의 대립유전자 특이적 올리고뉴클레오티드 프로브와 샘플을 접촉시키는 단계; SNP의 대립유전자와 상기 대립유전자 특이적 올리고뉴클레오티드 프로브 사이의 대립유전자 특이적 결합을 통해 이중 가닥 혼성화 복합체를 생성하는 단계; 및 SNP의 대립유전자와 상기 대립유전자 특이적 올리고뉴클레오티드 프로브 사이의 대립유전자 특이적 결합을 통해 새롭게 생성된 이중 가닥 혼성화 복합체를 검출하는 단계를 포함한다. 일부 실시양태에서, 상기 방법은 이중 가닥 혼성화 복합체의 PCR 증폭을 수행하는 단계를 추가로 포함한다.
다양한 실시양태에서, 본 발명은 대립유전자(예컨대, 표 1에 열거된 주요 대립유전자, 소수 대립유전자, 위험 대립유전자, 및 비위험 대립유전자) 각각에 대한 대립유전자 특이적 올리고뉴클레오티드 프로브를 제공한다. 본 발명에 따르면, 상기 대립유전자 특이적 올리고뉴클레오티드 프로브는 약 10-15, 15-20, 20-25, 25-30, 30-35, 35-40, 40-45 또는 45-50개의 뉴클레오티드를 포함할 수 있으며, 이들은 본원에 개시된 바와 같은 SNP의 다형성 위치를 포함하는 서열 분절과 동일하거나 상보적이고; 이들은 다형성 위치에서 하나 또는 다른 대립유전자에 특이적이다. 비제한적인 예로서, rs10247487은 그의 다형성 위치(예를 들어, 하기 예시 서열(서열 번호 1)의 뉴클레오티드 501에서 "Y")에서 T 또는 C 대립유전자(정방향 가닥의 경우)를 갖는다.
따라서, rs10247487에서 T 대립유전자에 대한 대립유전자 특이적 올리고뉴클레오티드 프로브는 비제한적 예로서 21개 뉴클레오티드를 포함할 수 있으며; 이들 21개 뉴클레오티드는 뉴클레오티드 501이 T 대립유전자로서 설정된 상기 예시 서열의 서열 분절 481-501, 482-502, 483-503, 484-504, 485-505, 486-506, 487-507, 488-508, 489-509, 490 -511, 491-511, 492-512, 493-513, 494-514, 495-515, 496-516, 497-517, 498-518, 499-519, 500-520 또는 501-521과 동일하거나 상보적이다. 반대로, rs10247487에서 C 대립유전자에 대한 대립유전자 특이적 올리고뉴클레오티드 프로브는 비제한적 예로서 21개 뉴클레오티드를 포함할 수 있으며; 이들 21개 뉴클레오티드는 뉴클레오티드 501이 C 대립유전자로서 설정된 상기 예시 서열의 서열 분절 481-501, 482-502, 483-503, 484-504, 485-505, 486-506, 487-507, 488-508, 489-509, 490 -511, 491-511, 492-512, 493-513, 494-514, 495-515, 496-516, 497-517, 498-518, 499-519, 500-520 또는 501-521과 동일하거나 상보적이다.
다양한 실시양태에서, 상기 대립유전자 특이적 올리고뉴클레오티드 프로브는 하나 이상의 형광 염료로 표지되며, 이중 가닥 혼성화 복합체를 검출하는 단계는 형광 염료로부터 형광 신호를 검출하는 단계를 포함한다. 일부 실시양태에서, 상기 대립유전자 특이적 올리고뉴클레오티드 프로브는 리포터 염료 및 켄처 염료로 표지된다. 일부 실시양태에서, 이중 가닥 혼성화 복합체를 검출하는 단계는 이중 가닥 혼성화 복합체의 전기영동 이동성을 검출하는 단계를 포함한다.
변이 대립유전자 또는 하플로타입의 존재 또는 부재를 검출하기 위해 다양한 방법이 사용될 수 있다. 예로서, 개체로부터의 핵산의 효소적 증폭을 이용하여 후속 분석을 위한 핵산을 수득할 수 있다. 변이 대립유전자 또는 하플로타입의 존재 또는 부재는 또한 효소 증폭 없이 개체의 핵산으로부터 직접 결정될 수 있다.
변이 대립유전자 또는 하플로타입의 존재 또는 부재를 검출하는 단계는 중합 효소 연쇄 반응에 의한 개체의 핵산의 증폭을 수반할 수 있다. 핵산의 증폭을 위한 중합 효소 연쇄 반응의 사용은 당해 분야에 잘 알려져 있다(예를 들어, 문헌[Mullis et al. (Eds.), The Polymerase Chain Reaction, Birkhauser, Boston, (1994)] 참조).
개체로부터의 핵산의 분석은 증폭 여부와 관계없이 다양한 기술 중 어느 하나를 사용하여 수행될 수 있다. 유용한 기술로는 제한 없이 중합 효소 연쇄 반응에 기반한 분석, 서열 분석 및 전기영동 분석이 포함된다. 본원에 사용된 바와 같이, 용어 "핵산"은 예를 들어 게놈 DNA, cDNA 및 mRNA를 포함하는 단일 또는 이중 가닥 DNA 또는 RNA 분자와 같은 폴리뉴클레오티드를 의미한다. 용어 핵산은 천연 및 합성 기원의 핵산 분자뿐만 아니라 천연 핵산 분자의 센스 또는 안티센스 가닥 또는 둘 모두를 나타내는 선형, 원형 또는 분지형 배열의 분자를 포함한다.
어플라이드 바이오시스템즈(Applied Biosystems)로부터 구입할 수 있는 택맨B 대립유전자 판별 분석(TaqmanB allelic discrimination assay)은 변이 대립유전자의 존재 또는 부재를 결정하는데 유용할 수 있다. 택맨B 대립유전자 판별 분석에서, 각 대립유전자에 대해 특이적인, 형광 염료로 표지된 프로브를 제작한다. 프로브는 각 대립유전자의 증폭을 구분하기 위해 FAM 및 VICTM과 같은 상이한 형광 리포터 염료를 포함한다. 또한, 각 프로브는 한쪽 말단에 형광 공명 에너지 전달(FRET: fluorescence resonant energy transfer)에 의해 형광을 소멸시키는 켄처 염료를 가진다. PCR 중에, 각 프로브는 개체로부터의 핵산 내 상보적인 서열에 특이적으로 어닐링한다. Taq 중합 효소의 5' 뉴클레아제 활성을 사용하여 대립유전자에 혼성화하는 프로브만을 절단한다. 절단은 리포터 염료를 켄처 염료로부터 분리하여 리포터 염료에 의한 형광을 증가시킨다. 따라서, PCR 증폭에 의해 생성된 형광 신호는 대립유전자가 샘플에 존재함을 나타낸다. 프로브와 대립유전자 사이의 불일치는 Taq 중합 효소에 의한 프로브 혼성화 및 절단의 효율을 모두 감소시켜, 형광 신호가 거의 없거나 전혀 발생하지 않게 한다. 대립유전자 판별 분석에서 특이성은 예를 들어 문헌[Kutyavin et al., "3'-minor groove binder-DNA probes increase sequence specificity at PCR extension temperature, "Nucleic Acids Research 28:655-661 (2000)]에 기재된 바와 같이 DNA 프로브에 DNA 작은 홈 결합제(MGB: minor groove binder) 기를 접합시킴으로써 향상될 수 있다. 작은 홈 결합제는 디히드로시클로피롤로인돌 트리펩티드(DPI)와 같은 화합물을 포함하나 이에 제한되지 않는다.
또한, 서열 분석은 변이 대립유전자 또는 하플로타입의 존재 또는 부재를 결정하는데 유용할 수 있다.
제한 단편 길이 다형성(RFLP: Restriction fragment length polymorphism) 분석은 또한 특정 대립유전자의 존재 또는 부재를 결정하는데 유용할 수 있다(Jarcho et al. in Dracopoli et al., Current Protocols in Human Genetics pages 2.7.1-2.7.5, John Wiley & Sons, New York; Innis et al.,(Ed.), PCR Protocols, San Diego: Academic Press, Inc. (1990)). 본원에서 사용된 바와 같이, 제한 단편 길이 다형성 분석은 핵산의 분해를 촉매하고 특정 염기 서열, 일반적으로 팔린드롬 또는 역위 반복을 인식하는 엔도뉴클레아제인 제한 효소를 사용하여 유전자 다형성을 구별하는 방법이다. 당업자는 RFLP 분석의 사용이 다형성 부위에서 2개의 대립유전자를 구별할 수 있는 효소에 의존한다는 것을 이해한다.
대립유전자 특이적 올리고뉴클레오티드 혼성화는 또한 변이 대립유전자 또는 하플로타입을 검출하는데 사용될 수 있다. 대립유전자 특이적 올리고뉴클레오티드 혼성화는, 예를 들어 변이 대립유전자 또는 하플로타입을 포함하는 서열에 대해 완벽하게 상보적인 서열을 갖는 표지된 올리고뉴클레오티드 프로브의 사용에 기초한다. 적절한 조건하에서, 대립유전자 특이적 프로브는 변이 대립유전자 또는 하플로타입을 함유하는 핵산에 혼성화하지만, 프로브와 비교하여 하나 이상의 뉴클레오티드 불일치를 갖는 다른 대립유전자 또는 하플로타입에는 혼성화하지 않는다. 원하는 경우, 대안적인 대립유전자와 일치하는 두 번째 대립유전자 특이적 올리고뉴클레오티드 프로브도 사용될 수 있다. 유사하게, 대립유전자 특이적 올리고뉴클레오티드 증폭 기술은 예를 들어, 변이 대립유전자 또는 하플로타입의 뉴클레오티드 서열에 완벽하게 상보적이지만 다른 대립유전자 또는 하플로타입과 비교하여 하나 이상의 불일치를 갖는 대립유전자 특이적 올리고뉴클레오티드 프라이머를 사용함으로써 변이 대립유전자 또는 하플로타입을 선택적으로 증폭시키는데 사용될 수 있다(Mullis et al., 상기 문헌, (1994)). 당업자는 변이 대립유전자 또는 하플로타입과 다른 대립유전자 또는 하플로타입을 구별하는 하나 이상의 뉴클레오티드 불일치가 바람직하게는 대립유전자 특이적 올리고뉴클레오티드 혼성화에 사용되는 대립유전자 특이적 올리고뉴클레오티드 프라이머의 중심에 위치함을 이해한다. 대조적으로, PCR 증폭에서 사용되는 대립유전자 특이적 올리고뉴클레오티드 프라이머는 바람직하게는 프라이머의 3 '말단에서 변이 대립유전자 또는 하플로타입과 다른 대립유전자를 구별하는 하나 이상의 뉴클레오티드 불일치를 함유한다.
헤테로듀플렉스 이동성 분석(HMA: heteroduplex mobility assay)은 변이 대립유전자 또는 하플로타입을 검출하는데 사용될 수 있는 잘 알려진 또 다른 분석법이다. HMA는 불일치를 갖는 DNA 이중 가닥이 폴리아크릴아미드 겔에서 완벽하게 염기쌍을 이룬 이중 가닥의 이동성에 비해 감소된 이동성을 보이기 때문에 다형성 서열의 존재를 검출하는데 유용하다(Delwart et al., Science 262:1257-1261 (1993); White et al., Genomics 12:301-306 (1992)).
또한, 단일 가닥 구조 다형성(SSCP: single strand conformational, polymorphism) 기술이 변이 대립유전자 또는 하플로타입의 존재 또는 부재를 검출하는데 사용될 수 있다(문헌[Hayashi, K., Methods Applic. 1:34-38 (1991)] 참조). 이 기술은 비변성 겔 전기영동 시 변경된 전기영동 이동성을 생성하는 단일 가닥 DNA의 2차 구조의 차이를 기반으로 돌연변이를 검출하는 데 사용될 수 있다. 다형성 단편은 검사 단편의 전기영동 패턴을 공지된 대립유전자를 함유하는 상응하는 표준 단편과 비교함으로써 검출된다.
변성 구배 겔 전기영동(DGGE: Denaturing gradient gel electrophoresis)이 또한 변이 대립유전자 또는 하플로타입을 검출하는데 사용될 수 있다. DGGE에서 이중 가닥 DNA는 증가하는 변성제 농도를 포함하는 겔에서 전기영동되며; 불일치 대립유전자로 이루어진 이중 가닥 단편은 더 빠르게 융해하는 단편을 가지며, 이는 이러한 단편이 완벽하게 상보적인 서열과 비교하여 다르게 이동하게 한다(Sheffield et al., "Identifying DNA Polymorphisms by Denaturing Gradient Gel Electrophoresis" in Innis et al., 상기 문헌, 1990).
변이 대립유전자 또는 하플로타입의 존재 또는 부재를 결정하는데 유용한 다른 분자적 방법은 당 업계에 공지되어 있으며 본 발명의 방법에 유용하다. 변이 대립유전자 또는 하플로타입의 존재 또는 부재를 결정하기 위한 잘 알려진 다른 접근법은 자동화 서열 분석 및 RNA아제 불일치 기술을 포함한다(Winter et al., Proc. Natl. Acad. Sci. 82:7575-7579 (1985)). 또한, 다수의 대립유전자 또는 하플로타입의 존재 또는 부재가 결정되어야 하는 경우, 개별적인 대립유전자 또는 하플로타입이 분자적 방법의 임의의 조합에 의해 검출될 수 있음을 당업자는 이해한다. 일반적으로, 문헌[Birren et al. (Eds.) Genome Analysis: A Laboratory Manual Volume 1 (Analyzing DNA) New York, Cold Spring Harbor Laboratory Press (1997)]을 참조한다. 또한, 당업자는 다수의 대립유전자가 각각의 반응 또는 단일 반응("멀티플렉스" 분석)에서 검출될 수 있음을 이해한다. 상기를 고려하여, 당업자는 본 발명의 방법이 상기 기재된 잘 알려진 분석법 또는 당 업계에서 인정되는 다른 유전자 분석법 중 하나 또는 임의의 조합을 사용하여 실시될 수 있음을 인식한다.
유전자 확인
본 발명의 다양한 실시양태는 병태와 관련된 유전자/유전자좌를 확인하는 방법으로서, 병태의 코호트의 샘플로부터 유전자 데이터를 취득하는 단계; 유전자 데이터에 대해 GLS 변환을 수행함으로써, 유전자 데이터를 비상관화하는 단계; GLS 변환된 유전자 데이터에 대해 유전자 기반 분석을 수행하는 단계; 및 병태와 관련된 유전자/유전자좌를 확인하는 단계를 포함하는 방법을 제공한다. 다양한 실시양태에서, 병태는 IBD, CD 또는 UC, 또는 이들의 조합이다. 일부 실시양태에서, 코호트는 상관된 대상체 또는 가족 대상체를 포함한다. 다른 실시양태에서, 유전자 데이터는 SNP 유전자형을 포함한다. 또 다른 실시양태에서, GLS 변환을 수행하는 단계는, 함수 , , , , 또는 이들의 조합에 따라 유전자 데이터를 변환하는 단계를 포함한다.
다양한 실시양태에서, 유전자 기반 분석을 수행하는 단계는 독립적인 또는 비상관 대상체의 가정에 기초하여 유전자 기반 검사를 적용하는 단계를 포함한다. 다양한 실시양태에서, 유전자 기반 분석을 수행하는 단계는 C-알파 SKAT, SKAT-CommonRare, CMC, WSS, 가변 임계치, 또는 포괄적 접근법, 또는 이들의 조합을 적용하는 단계를 포함한다.
본 발명의 다양한 실시양태는 병태와 관련된 유전자/유전자좌를 확인하는 방법을 제공한다. 상기 방법은 병태의 코호트의 샘플로부터 유전자 데이터를 취득하는 단계; 유전자 데이터에 대해 GLS 변환을 수행함으로써 유전자 데이터를 비상관화하는 단계; GLS 변환된 유전자 데이터에 대한 유전자 기반 분석을 수행하는 단계; 및 병태와 관련된 유전자/유전자좌를 확인하는 단계를 포함한다. 다양한 실시양태에서, 병태는 IBD, CD 또는 UC, 또는 이들의 조합이다.
다양한 실시양태에서, 코호트는 상관된 대상체 또는 가족 대상체를 포함한다. 일부 실시양태에서, 코호트는 병태로 진단받은 사례 대상체를 포함한다. 일부 실시양태에서, 코호트는 건강하거나 병태로 진단받지 않은 대조군 대상체를 포함한다. 다양한 실시양태에서, 유전자 데이터는 SNP 유전자형을 포함한다.
다양한 실시양태에서, GLS 변환을 수행하는 단계는 상기한 함수 (5) 내지 (8)에 따라 유전자 데이터를 변환하는 단계를 포함한다. 다양한 실시양태에서, 유전자 기반 분석을 수행하는 단계는 독립적인 또는 비상관 대상체의 가정에 기초하여 유전자 기반 검사를 적용하는 단계를 포함한다. 다양한 실시양태에서, 유전자 기반 분석을 수행하는 단계는 C-알파, SKAT, SKAT-CommonRare, CMC, WSS, 가변 임계치 또는 포괄적 접근법, 또는 이들의 조합을 적용하는 단계를 포함한다.
본 발명의 키트
본 발명의 다양한 실시양태는 또한 키트를 제공한다. 키트는 하나 이상의 유전자/유전자좌에서 하나 이상의 대립유전자를 검출하기 위한 하나 이상의 검출 제제; 병태와 관련된 유전자/유전자좌를 확인하고/하거나, IBD 발병의 저확률 또는 고확률을 예측하고/하거나, IBD에 대한 감수성 또는 방어를 예측하고/하거나, IBD를 진단하고/하거나, IBD를 치료하고/하거나, IBD 요법의 투여를 지시하기 위해 제제를 사용하는 설명서로 이루어질 수 있거나, 이들로 본질적으로 이루어질 수 있거나, 이들을 포함할 수 있다. 일부 실시양태에서, 하나 이상의 대립유전자는 IBD와 관련된 위험 대립유전자이다.
본 발명의 다양한 실시양태는 또한 키트를 제공한다. 키트는 하나 이상의 유전자/유전자좌에서 하나 이상의 대립유전자를 검출하기 위한 하나 이상의 검출 제제; 병태와 관련된 유전자/유전자좌를 확인하기 위해 제제를 사용하는 설명서로 이루어질 수 있거나, 이들로 본질적으로 이루어질 수 있거나, 이들을 포함할 수 있다. 다양한 실시양태에서, 키트는 병태의 코호트로부터 수득한 샘플을 추가로 포함한다. 다양한 실시양태에서, 병태는 IBD, 크론병(CD), 또는 궤양성 대장염(UC)이다.
본 발명의 다양한 실시양태는 또한 키트를 제공한다. 키트는 하나 이상의 유전자/유전자좌에서 하나 이상의 위험 대립유전자를 검출하기 위한 하나 이상의 검출 제제; IBD 발병의 저확률 또는 고확률을 예측하고/하거나, IBD에 대한 감수성 또는 방어를 예측하고/하거나, IBD를 진단하고/하거나, IBD를 치료하고/하거나, IBD 요법의 투여를 지시하기 위해 제제를 사용하는 설명서로 이루어질 수 있거나, 이들로 본질적으로 이루어질 수 있거나, 이들을 포함할 수 있다. 다양한 실시양태에서, 위험 대립유전자는 IBD와 관련된다. 다양한 실시양태에서, 키트는 IBD의 예후 및/또는 진단 및/또는 치료를 원하는 대상체로부터 수득한 샘플을 추가로 포함한다. 다양한 실시양태에서, IBD는 크론병(CD), 또는 궤양성 대장염(UC)이다.
다양한 실시양태에서, 하나 이상의 유전자/유전자좌는 표 1에 서열 번호 1 내지 341로서 열거된 유전자/유전자좌 중 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14개 이상, 또는 모두를 포함한다. 다양한 실시양태에서, 하나 이상의 유전자/유전자좌는 SLC26A4, DLG4, GIPR, ZHX3, TNRC6B, CDK6, PRR5L, WNT2B, LRRC16A, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), GTF2IRD2B, ETS1, SLC5A1 또는 TET2, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 하나 이상의 유전자/유전자좌는 ETS1, HIST1 클러스터(모든 히스톤 클러스터 1 유전자), CDK6, LRRC16A, 또는 이들의 조합을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 ETS1을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 HIST1 클러스터(모든 히스톤 클러스터 1 유전자)를 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 CDK6을 포함한다. 다양한 실시양태에서, 유전자/유전자좌는 LRRC16A를 포함한다.
다양한 실시양태에서, 키트는 IBD 요법을 추가로 포함한다. IBD 요법의 예는 항-TNF 요법 및 항-TL1A 요법을 포함하지만 이에 제한되지 않는다. 일부 실시양태에서, IBD 요법은 항-TNF 항체이다. 일부 실시양태에서, IBD 요법은 항-TL1A 항체이다.
키트는 하나 이상의 발명 요소 또는 모듈을 포함하는 재료 또는 구성요소의 집합체이다. 다양한 실시양태에서, 하나 이상의 검출 제제는 하나 이상의 SNP의 대립유전자에 특이적으로 결합한다. 일부 실시양태에서, 하나 이상의 SNP의 대립유전자는 주요 대립유전자, 소수 대립유전자, 또는 둘 다 일 수 있다. 일부 실시양태에서, 하나 이상의 SNP의 대립유전자는 위험 대립유전자, 비위험 대립유전자, 또는 방어 대립유전자, 또는 이들의 조합일 수 있다.
일부 실시양태에서, 하나 이상의 검출 제제는 표 1에 서열 번호 1 내지 341로서 열거된 하나 이상의 위험 대립유전자에 특이적으로 결합한다. 일부 실시양태에서, 하나 이상의 검출 제제는 표 1에 서열 번호 1 내지 341로서 열거된 위험 대립유전자 중 1, 2, 3, 4, 5, 6, 7, 8, 9, 10개 이상 또는 모두에 특이적으로 결합한다. 다양한 실시양태에서, 하나 이상의 검출 제제는 표 1에 서열 번호 1 내지 341로서 열거된 위험 대립유전자 중 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 99, 또는 100개 이상 또는 모두에 특이적으로 결합한다. 일부 실시양태에서, 하나 이상의 검출 제제는 표 1에 열거된 N개의 위험 대립유전자에 특이적으로 결합하며, N은 341 이하의 양의 정수(즉, 1≤N≤341)이다. 다양한 실시양태에서, 하나 이상의 검출 제제는 표 1에 서열 번호 1 내지 341로서 열거된 1-5, 5-10, 10-15, 15-20, 20-25, 25-30, 30-35, 35-40, 40-45, 45-50, 50-55, 55-60, 60-65, 65-70, 70-75, 75-80, 80-85, 85-90, 90-95, 또는 95-100개의 위험 대립유전자에 특이적으로 결합한다. 다양한 실시양태에서, 하나 이상의 검출 제제는 표 1에 서열 번호 1 내지 341로서 열거된 100-105, 105-110, 110-115, 115-120, 120-125, 125-130, 130-135, 135-140, 140-145, 145-150, 150-155, 155-160, 160-165, 165-170, 170-175, 175-180, 180-185, 185-190, 190-195, 또는 195-200개의 위험 대립유전자에 특이적으로 결합한다. 다양한 실시양태에서, 하나 이상의 검출 제제는 표 1에 서열 번호 1 내지 341로서 열거된 200-205, 205-210, 210-215, 215-220, 220-225, 325-230, 230-235, 235-240, 240-245, 245-250, 250-255, 255-260, 260-265, 265-270, 270-275, 275-280, 280-285, 285-290, 290-295, 또는 295-300개의 위험 대립유전자에 특이적으로 결합한다. 다양한 실시양태에서, 하나 이상의 검출 제제는 표 1에 서열 번호 1 내지 341로서 열거된 300-305, 305-310, 310-315, 315-320, 320-325, 325-330, 330-335, 335-340, 330-341개의 위험 대립유전자에 특이적으로 결합한다.
다양한 실시양태에서, 하나 이상의 검출 제제는 대상체로부터 수득한 생물학적 샘플을 접촉시키기 위해 적용되고; 하나 이상의 검출 제제와 하나 이상의 대립유전자 사이의 결합 수준이 검출된다. 일부 실시양태에서, 하나 이상의 검출 제제는 올리고뉴클레오티드 프로브, 핵산, DNA, RNA, 펩티드, 단백질, 항체, 앱타머 또는 소분자 또는 이들의 조합이다. 다양한 실시양태에서, 결합 수준은 마이크로어레이를 사용하여 검출된다. 일부 실시양태에서, 마이크로어레이는 올리고뉴클레오티드 마이크로어레이, DNA 마이크로어레이, cDNA 마이크로어레이, RNA 마이크로어레이, 펩티드 마이크로어레이, 단백질 마이크로어레이 또는 항체 마이크로어레이, 또는 이들의 조합이다.
다양한 실시양태에서, 하나 이상의 검출 제제는 하나 이상의 대립유전자에 특이적인 올리고뉴클레오티드 프로브이다. 다양한 실시양태에서, 올리고뉴클레오티드 프로브는 형광 염료로 표지된다. 다양한 실시양태에서, 올리고뉴클레오티드 프로브는 리포터 염료 및 켄처 염료를 포함한다. 다양한 실시양태에서, 키트는 하나 이상의 검출 제제로부터 형광 신호를 검출하도록 구성된 모듈을 추가로 포함한다. 다양한 실시양태에서, 키트는 PCR 증폭을 수행하기 위해 구성된 모듈을 추가로 포함한다.
본 발명의 키트에 구성된 구성요소의 정확한 특성은 그 의도된 목적에 따라 결정된다. 사용 설명서가 키트에 포함될 수 있다. "사용 설명서"에는 전형적으로 원하는 결과에 영향을 주는 키트의 구성요소를 사용하는데 이용되는 기술을 설명하는 구체적인 표현이 포함된다. 경우에 따라, 키트는 당업자에 의해 쉽게 인식되는 바와 같이 스프레이 병 또는 캔, 희석제, 완충액, 약학적으로 허용되는 담체, 주사기, 카테터, 애플리케이터(예를 들어, 크림, 겔 또는 로션 등의 애플리케이터), 피펫팅 또는 측정 도구, 붕대 재료 또는 다른 유용한 용품과 같은 기타 유용한 구성요소도 포함한다.
키트에 모인 재료 또는 구성요소는 그들의 조작성 및 유용성을 유지하는 편리하고 적절한 방법으로 보관되어 의사에게 제공될 수 있다. 예를 들어, 검출 제제는 용해, 탈수 또는 동결 건조된 형태일 수 있으며; 실온, 냉장 또는 냉동 온도로 제공될 수 있다. 구성요소는 전형적으로 적절한 포장재(들)에 들어 있다. 본원에서 사용되는 바와 같이, "포장재"라는 용어는 본 발명의 조성물 등과 같은 키트 내용물을 보관하는데 사용되는 하나 이상의 물리적 구조를 의미한다. 포장재는 잘 알려진 방법으로, 바람직하게는 멸균의, 오염이 없는 환경을 제공하도록 구성된다. 키트에 사용되는 포장재는 분석 및 요법에 통상적으로 사용되는 포장재이다. 본원에 사용된 바와 같이, 용어 "패키지"는 개별 키트 구성요소를 담을 수 있는 유리, 플라스틱, 종이, 호일 등과 같은 적절한 고체 매트릭스 또는 물질을 의미한다. 따라서, 예를 들어, 패키지는 본원에 기재된 바와 같은 조성물의 적절한 양을 담는데 사용되는 유리 바이알일 수 있다. 포장재에는 일반적으로 키트 및/또는 구성요소의 내용물 및/또는 목적을 나타내는 외부 라벨이 있다.
신규 유전자/영역, SNP, 및 위험 대립유전자
표 1은 본 발명의 다양한 실시양태에 따른 유전자/영역, SNP, 서열 번호(서열 번호 1 - 341) 및 위험 대립유전자의 정보를 제공한다. "Dis"는 질병을 의미한다. "gene.i"는 유전자 ID를 의미한다. "SNP"는 단일 뉴클레오티드 다형성(single nucleotide polymorphism)을 의미한다. "rsID"는 참조 SNP 클러스터 ID(rs 번호)를 나타낸다. "chr"은 염색체를 의미한다. "pos_hg19"는 인간 게놈 버전 19에서의 위치를 나타낸다. "pos_hg18"은 인간 게놈 버전 18에서의 위치를 나타낸다. "A1"은 소수 대립유전자를 의미한다. "A2"는 주요 대립유전자를 의미한다. "risk.allele"은 질병 위험을 증가시키는 대립유전자를 의미한다. "OR.risk.allele"은 위험 대립유전자에 대한 메타 분석에서 오즈비를 의미한다. F_A_cedars"는 세다르스(Cedars) 이환된 사례에서 소수 대립유전자 빈도를 의미한다. "F_U_cedars"는 세다르스의 이환되지 않은 대조군에서 소수 대립유전자 빈도를 의미한다. "OR_cedars"는 세다르스 코호트에서 오즈비를 나타낸다. "SE_cedars"는 세다르스 코호트에서 log(OR)에 대한 표준 오차를 나타낸다. "L95_cedars"는 세다르스 코호트에서 OR의 95% 신뢰 구간의 하위 경계를 나타낸다. "U95_cedars"는 세다르스 코호트에서 OR의 95% 신뢰 구간의 상위 경계를 나타낸다. "STAT_cedars"는 세다르스 코호트에서 검정 통계(Z-값)를 나타낸다. "P_cedars"는 세다르스 코호트에서 P-값을 나타낸다. "F_A_IBDgc"는 IBDGC 이환된 사례에서 소수 대립유전자 빈도를 의미한다. ""F_U_IBDgc"는 IBDGC 이환되지 않은 대조군에서 소수 대립유전자 빈도를 의미한다. "OR_IBDgc"는 IBDGC 코호트에서 오즈비를 의미한다. "SE_IBDgc"는 IBDGC 코호트에서 log(OR)에 대한 표준 오차를 나타낸다. "L95_IBDgc"는 IBDGC 코호트에서 OR의 95% 신뢰 구간의 하위 경계를 나타낸다. "U95_IBDgc"는 IBDGC 코호트에서 OR의 95% 신뢰 구간의 상위 경계를 나타낸다. "STAT_IBDgc"는 IBDGC 코호트의 검정 통계(Z 통계)를 나타낸다. "P_IBDgc"는 IBDGC 코호트에서 P-값을 나타낸다. "beta_meta_fixed"는 메타 분석에서 log(OR)를 나타낸다. "se_meta_fixed"는 메타 분석에서 log(OR)의 표준 오차를 나타낸다. "P_meta_fixed"는 메타 분석에서 P-값을 나타낸다.
<표 1> (파트 1)
(파트 2)
(파트 3)
많은 변이 및 대안적인 요소가 본 발명의 실시양태에 개시되어 있다. 당업자에게는 또 다른 변이 및 대안적인 요소가 명백할 것이다. 이러한 변이 중에서, 제한 없이, 본 발명의 방법, 조성물, 키트, 및 시스템에 대한 구성 모듈의 선택, 및 이에 의해 진단, 예측 또는 치료될 수 있는 다양한 병태, 질병 및 장애가 있다. 본 발명의 다양한 실시양태는 임의의 이들 변이 또는 요소를 구체적으로 포함하거나 배제할 수 있다.
일부 실시양태에서, 본 발명의 특정 실시양태를 기술하고 청구하는데 사용되는 성분의 양, 특성, 예를 들어 농도, 반응 조건 등을 나타내는 숫자는 일부 경우에 용어 "약"으로 수식되는 것으로 이해해야 한다. 따라서, 일부 실시양태에서, 서술된 설명 및 첨부된 청구 범위에 기재된 수치 파라미터는 특정 실시양태에 의해 얻고자 하는 원하는 특성에 따라 달라질 수 있는 근사치이다. 일부 실시양태에서, 수치 파라미터는 보고된 유효 자릿수의 개수를 감안하고 통상의 반올림 기법을 적용하여 해석되어야 한다. 본 발명의 일부 실시양태의 넓은 범위를 기술하는 수치 범위 및 파라미터가 근사치임에 불구하고, 특정 실시예에 기재된 수치는 가능한 한 정확하게 보고된다. 본 발명의 일부 실시양태에서 제시된 수치는 각각의 검사 측정치에서 확인되는 표준 편차로부터 반드시 기인하는 소정의 오차를 포함할 수 있다.
본원에 개시된 본 발명의 대안적인 요소 또는 실시양태의 군의 형성은 제한으로서 해석되어서는 안 된다. 각 군의 구성원은 개별적으로, 또는 군의 다른 구성원 또는 본원에서 발견되는 다른 요소와 조합하여 언급되거나 청구될 수 있다. 군의 하나 이상의 구성원은 편의성 및/또는 특허성을 이유로 군에 포함되거나 군에서 삭제될 수 있다. 그러한 포함 또는 삭제가 발생하는 경우, 명세서는 변형된 바와 같은 군을 포함하는 것으로 본원에서 간주하여, 첨부된 청구 범위에서 사용된 모든 마쿠시 군의 기재된 설명을 충족시킨다.
실시예
본 발명은 하기 실시예에 의해 더 설명될 것이며, 이는 순전히 본 발명을 예시하는 것으로 의도되며 어떤 식으로든 본 발명을 제한하는 것으로 간주해서는 안 된다. 하기 실시예는 청구된 발명을 더 잘 설명하기 위해 제공되며 본 발명의 범위를 제한하는 것으로 해석해서는 안 된다. 구체적인 재료가 언급되는 범위까지도, 이는 단지 예시를 위한 것이며, 본 발명을 제한하고자 하는 것은 아니다. 당업자는 발명능을 발휘하지 않고도 본 발명의 범위를 벗어나지 않으면서 동등한 수단 또는 반응물을 개발할 수 있다.
실시예 1 GLS-SKAT: 가족 구조를 갖는 코호트에서 유전자 기반 분석을 위한 새로운 접근법
유전자 기반 분석은 복합 질병에 대한 신규 유전자좌를 확인하는데 중요할 수 있다. 그러나 이용 가능한 대부분의 접근법은 집단 기반의 사례 - 대조군 샘플을 겨냥하여 독립적인 가정에 기초한다. 여기서 본 발명자들은 복잡한 가족 구조를 가진 데이터를 사용하여 유전자를 확인하는 일반화된 최소 제곱(GLS) 기반 분석 전략을 제안하였다. 이 접근법은 다음과 같이 설명할 수 있다.
일련의 유전 인자 X 와 결과 y 의 연관성의 선형 명세화가 주어지면, 다음을 얻는다:
(1)
결과 y의 분산을 다음과 같이 쓸 수 있다고 가정해보자.
(2)
샘플 내 대상체가 상관관계가 없는 경우, β의 추정치는 다음과 같이 쓸 수 있다:
(3)
(4)
샘플들이 상관관계가 있을 때, 예를 들어. 가족 계열 샘플에서, β의 일반 최소 제곱(OLS: ordinary least squares) 추정은 문제가 될 것이며 의 편향된 추정으로 이어질 것이다. 이는 대부분의 유전자 기반 검사를 포함하여 독립적인 가정에 기초한 모든 모델에 영향을 줄 것이다.
선형 모델에서 독립성 가정의 위반에 대한 해결책 중 하나는 일반화된 최소 제곱 변환을 수행하는 것이다. 다음으로 놓자:
(5)
그리고 GLS 변환된 모델은 다음과 같이 쓸 수 있다:
(6)
변환된 모델에 기초한 추정은 다음과 같이 쓸 수 있다:
(7)
(8)
분명히 이는 작도에 의한 최량 선형 비편향 추정량(BLUP: Best Linear Unbiased Predictor)이다. 즉, GLS 변환 후 데이터는 비편향 추정량을 유지하면서 데이터는 비상관화된다. 따라서 독립성 가정으로 개발된 모든 모델은 GLS 변환된 데이터에 적용될 수 있다. 여기에 유전자 기반 분석을 위해, 본 발명자들은 독립성 가정이 유지되면서 대부분의 시나리오에서 더 나은 성능을 나타내기 때문에 GLS 변환된 데이터에 SKAT-CommonRare를 적용하기로 선택한다. 친족 행렬의 분해의 역수로서 변환 행렬 G를 계산하였다. 이것을 GLS-SKAT라고 부른다.
실시예 2 유전자 기반 분석을 통해 확인된 다수의 신규 유전자좌
단일 SNP 기반의 연관성은 대부분의 GWAS 소견을 유도하는데, 그 이유는 주로 간단하고 직설적이기 때문이다(도 1A). 이는 단일 SNP의 빈도가 사례 및 대조군에서 동일한지를 검사한다. 그러나 다수의 검사 보정, 변이 수가 증가함에 따른 어려움, 다수의 약한 신호 간과, 몇몇 인과 관계 유전자좌의 누락을 포함한 몇 가지 단점이 있다.
유전자 기반 분석은 단일 SNP를 검토하는 대신에 유전자 전체를 조사한다(도 1B). 이는 주어진 유전자에서 모든 SNP 분포가 사례와 대조군에서 동일한지를 검사한다. 이는 효과를 약한 인과 관계 SNP가 여러 개 있을 때 더 강력하다. 이는 수백만 개의 SNP와 약 25,000개의 알려진 유전자에 대한 다수의 검사 패널티를 감소시킬 수 있다.
유전자 기반 분석을 위한 현재 접근법은 데이터 붕괴 접근법(예를 들어, 결합 다변량 및 붕괴 접근법(CMC: Combining Multivariate Collapsing approach), 가중합 통계(WSS: Weighted Sum Statistics), 가변 임계치 및 포괄적 접근법) 및 분포 기반 접근법(예를 들어, C-알파, SNP 세트 커널 연관성 검사(SKAT: SNP Set Kernel Association Test), 및 SKAT-CommonRare)을 포함한다. 이러한 접근법의 대부분은 대상체의 독립성을 가정하여 집단 기반 설계에만 적용될 수 있다.
본 발명은 가족에서의 유전자 기반 분석을 위한 새로운 접근법 GLS-SKAT를 제공한다. 다음 선형 모델을 고려하여:
독립적인 대상체의 경우:
상관된 대상체의 경우:
상관된 데이터를 독립적으로 변환하기 위해, 다음으로 놓는다:
선형 모델에서 T를 곱할 수 있다:
그런 후,
즉, 상관된 데이터는 이제 "비상관화"된다.
GLS 변환된 데이터를 이용한 OLS 추정:
이것은 정확히 참 모델의 최대 우도 추정치이다:
GLS-SKAT를 아이칩(iChip) 데이터 세다르스 vs. BBC:4600건 사례 및 6800건의 대조군에 적용시킨다. SKAT-CommonRare를 IBDGC(세다르스 및 BBC 샘플 제외): 30200건 사례 및 29700건 대조군에 적용시킨다. 인자를 혼입하기 위해 PCA를 대조군에 포함시킨다. 유전자 영역을 각 유전자의 상류 및 하류 100Kb로 정의한다. 분석을 적어도 2개의 SNP을 가진 IBD와 유전자(약 8000개 유전자)에 중점을 둔다. 따라서 유의한 임계 값은 0.05/8000 = 6.25E-6이다. 피셔의 결합 P 값을 유전자 수준의 p-값의 메타 분석에 사용한다.
TET2는 Tet 메틸시토신 디옥시게나제 2를 코딩하며, Foxp3 탈메틸화에 관여하여 조절 T 세포 분화를 유도하고 면역 항상성을 유지한다.
LRRC16A(류신 풍부 반복체 함유 16A)는 단백질 코딩 유전자이다. LRRC16A와 관련된 질병에는 급성 요산염 신장 병증이 포함된다. 이 유전자의 중요한 파라로그는 LRRC16B이다. LR16A_HUMAN Q5VZK9는 CAPZA2에 높은 친화성으로 결합하여 액틴 미늘모양 말단에 대한 CAPZA2 친화성을 현저하게 감소시킨다. 이것은 CAPZA2의 존재하에서 시드(seed)로부터 연신율을 증가시킨다; 그러나 필라멘트를 핵 주위로 모을 수 없는 것으로 보인다. 이것은 CAPZA2에 의해 캡핑된 미늘모양 말단을 빠르게 캡핑제거(uncapping)하고 미늘 모양 말단 액틴 중합 b 유사성을 향상시킨다. 이것은 라멜리포듐에서 액틴 역동성을 조절할 수 있으며 세포 이동에 필요하다.
전체 HIST1 영역은 조인트(joint) 연관성을 갖는다. HIST1 클러스터 부분 1(∼ 26.2M, 제1부분) 및 HIST1 클러스터 부분 2(∼ 27.8M, 제2부분). ∼ 1.6M(26.2M에서 27.8M까지)을 하나의 큰 영역으로 결합한 후, 전체 영역 기반 연관성 P 값은 1.64x10-7이다.
BTN3A1/A2/A3은 흥미있는 유전자 클러스터이다. 부티로필린, 서브패밀리 3은 B7 패밀리 구성원에 속하며, T 및 NK 세포와 같은 다양한 면역 세포에서 발현된다. BTN3/CD277은 3개의 구조적으로 관련된 구성원, BTN3A1, BTN3A2 및 BTN3A3을 포함한다. 이는 적응 면역 반응에서 T 세포 반응에서 역할을 하며, 활성화된 T 세포로부터 IFNG의 분비를 억제한다. 이는 인간 γδ T 세포 항원 활성화에 중요한 역할을 한다. 이는 T 및 NK 세포에서 면역 신호의 보조 조절 인자로서 CD277에 대해 차별적인 역할을 한다(예를 들어, 문헌[Messal N, Mamessier E, et al. Eur J Immunol. 2011 Dec;41(12):3443-54) 참조). T 세포가 모든 BTN3/CD277 전사체를 발현하는 반면, NK 세포는 B30.2 세포 내 도메인이 결여된 BTN3A2를 주로 발현한다. 또한, NKp30 유도된 사이토카인 생산은 BTN3A2의 특이적 결합에 의해 감소하지만 BTN3A1 유발에 의해 감소되지 않는다.
본 발명자들은 아이칩 데이터의 유전자 기반 분석을 통해 14개의 신규 유전자좌를 확인하였다(도 4 및 표 1). 이들 모두는 다수의 약한 신호를 보이지만 일부 신호는 조인트 모델에서 매우 강하다. BTN3A2는 또한 LRRC16A 영역의 eQTL 분석에 기초한 IBD 병인에 강하게 관련된다.
실시예 3 유전자 기반 분석에 의한 다수의 신규 IBD 유전자좌의 확인
주로 단일 SNP 분석을 통해 염증성 장 질환(IBD)에서 200개 이상의 유전자좌를 확인하였다. 본 연구에서는, 본 발명자들은 단일 SNP 분석에서 놓친 신규 IBD 유전자좌를 확인하기 위해 유전자에서 모든 SNP 신호로부터의 신호를 결합하는 유전자 기반 분석을 활용하고자 한다.
세다르스-신나이 메디칼 센터(Cedars-Sinai Medical Center)의 3312건 IBD 사례 및 이뮤노칩(ImmunoChip) 데이터가 있는 7154건 가족 및 집단 기반 대조군을 발견(discovery) 코호트로서 포함하였다. IBDGC에서 유전자 수준의 p 값이 0.05 미만인 유전자를 복제하였다(30179건 사례 및 29678건 대조군, 발견 단계와 중복된 샘플은 제외됨). SKAT-CommonRare를 수행하여 유전자 수준의 연관성을 평가하였다. 피셔의 결합 p 값을 발견 및 복제 코호트로부터의 p 값을 결합하여 계산하였다. 본페로니(Bonferroni) 보정된 유의성 임계치 6.25E-6을 유전자 기반 P-값에 사용하여 아이칩에서 적어도 2개의 SNP를 가진 7,924개의 유전자에 대해 계수하였다.
IL23R 및 NOD2와 같이 공지된 IBD 유전자 이외에, 본 발명자들은 IBD와 관련된 다수의 신규 유전자를 확인하였다. 이러한 유전자에는 TET2(발견 p 값 0.019, 복제 p 값 2.82E-9, 결합 p 값 1.33E-9); LRRC16A(발견 p 값 1.55E-6, 복제 p 값 3.43E-5, 결합 p 값 1.19E-8); 및 히스톤 클러스터 1 유전자좌 내 다수의 유전자(예: HIST1H4H,
발견 p-값 2.89E-5, 복제 p-값 2.44E-4, 결합 p-값 4.24E-6; HIST1H1B. 발견 p-값 1.45E-4, 복제 p-값 8.61E-5, 결합 p-값 2.41E-7)이 포함된다. 이들 유전자들의 SNP는 표 1에 열거한다.
우리의 생물 정보학 분석은 LRRC16A 신호를 유발하는 최상위 SNP(rs7752195)가 적응 면역 반응을 조절하는데 중요한 역할을 하는 BTN3A2의 강한 발현 양적 형질 유전자좌(eQTL: expression qualitative trait locus)임을 나타낸다(seeQTL에서, p = 5.96E-51; SCANdb에서, p = 8E-9; GeneVar에서, p = 0.0025). 더욱이, 현재 연구에서 확인된 최상위 유전자인 전위 (Tet) 메틸시토신 디옥시게나제 2를 코딩하는 TET2는 FOXP3의 DNA 탈메틸화를 통해 T 세포 분화를 유도한다고 보고되었다. 또한, 이는 염색질 구조의 조절에 의해 인터류킨-6 (IL-6) 전사를 매개하는 것으로 보고되었다.
특정 이론에 얽매이지 않고서, 현재 연구에서 유전자 기반 분석을 통해 확인된 신규 유전자좌는 이전의 단일 SNP 기반 GWAS를 유전자 수준에서 재검토하는 것이 가치가 있음을 강하게 시사한다.
상기한 다양한 방법 및 기술은 본 출원을 수행하기 위한 여러 방식을 제공한다. 물론, 기재된 모든 목적 또는 이점이 본원에 기술된 특정 실시양태에 따라 반드시 달성될 필요는 없음을 이해해야 한다. 따라서, 예를 들어, 당업자는, 본 방법이 본원에 교시되거나 시사되는 바와 같은 다른 목적 또는 이점을 반드시 달성하지는 않으면서 본원에 교시된 바와 같은 하나의 이점 또는 일단의 이점을 달성하거나 최적화하는 방식으로 수행될 수 있음을 인지할 것이다. 본원에 다양한 대안이 언급되어 있다. 일부 바람직한 실시양태는 하나, 또 다른, 또는 여러 특징을 특별히 포함하는 한편, 다른 실시양태는 하나, 또 다른 또는 여러 특징을 특별히 배제하는 한편, 또 다른 실시양태는 하나, 또 다른, 또는 여러 유리한 특징을 포함함으로써 특정 특징을 경감시킴을 이해해야 한다.
또한, 당업자는 상이한 실시양태로부터 다양한 특징의 적용 가능성을 인지할 것이다. 유사하게, 상기에서 논의된 다양한 요소, 특징, 및 단계뿐만 아니라 이러한 각 요소, 특징 또는 단계에 대해 다른 공지된 균등물은 본원에 기재된 원리들에 따라 방법을 수행하는 당업자에 의해 다양한 조합으로 사용될 수 있다. 다양한 요소, 특징, 및 단계 중에서 일부는 특별히 포함될 것이며, 다른 것들은 다양한 실시양태에서 특별히 배제될 것이다.
본 출원은 특정 실시양태 및 실시예와 관련하여 개시되었지만, 당업자는, 본 출원의 실시양태가 구체적으로 개시된 실시양태를 넘어 다른 대안적인 실시양태 및/또는 용도 및 이들의 변형 및 균등물로 확장된다는 것을 이해할 것이다.
본 출원의 바람직한 실시양태가 본 출원을 수행하기 위해 본 발명자에게 알려진 최선의 형태를 포함하여 본원에 기술된다. 이들 바람직한 실시양태에 대한 변이는 상기 설명을 읽음으로써 당업자에게 명백해질 것이다. 숙련된 기술자는 이러한 변이를 적절하게 사용할 수 있으며, 본 출원은 본원에 구체적으로 기술된 것과 다르게 실시될 수 있음이 고려된다. 따라서, 본 출원의 많은 실시양태는 적용 가능한 법률에 의해 허용되는 바와 같이 본원에 첨부된 청구 범위에 열거된 주제의 모든 변형 및 균등물을 포함한다. 또한, 본원에서 달리 지시되지 않는 한, 또는 문맥에 명백하게 반박되는 경우를 제외하고, 상기한 요소의 모든 가능한 변이에서 이들의 임의의 조합은 본 출원에 포함된다.
본원에서 참조된 모든 특허, 특허 출원, 특허 출원의 공보 및 기타 자료, 예를 들어 논문, 도서, 명세서, 간행물, 문서, 사물 및/또는 그 밖의 유사한 것들은 이로써 모든 목적을 위해 그 전문이 본 참고로 본원에 포함되는데, 상기와 관련된 출원 경과 기록, 본 문서와 일치하지 않거나 충돌하는 것 또는 현재 또는 나중에 본 문서와 관련된 청구 범위의 가장 넓은 범위에 대해 제한적인 영향을 줄 수 있는 것은 제외한다. 예로써, 포함된 임의의 자료와 관련된 용어의 설명, 정의 및/또는 사용과 본 문서와 관련된 것 사이에 불일치 또는 충돌이 있는 경우, 본 문서에서의 그 용어의 설명, 정의 및/또는 사용이 우선한다.
본원에 개시된 출원의 실시양태는 본 출원의 실시양태의 원리를 예시하는 것으로 이해해야 한다. 이용될 수 있는 다른 변형은 본 출원의 범위 내에 있을 수 있다. 따라서, 제한하는 것이 아니라 예로서, 본 출원의 실시양태의 대안적인 구성은 본원의 교시에 따라 이용될 수 있다. 따라서, 본 출원의 실시양태는 보여주고 설명된 바와 정확하게 같은 것에 제한되지는 않는다.
본 발명의 다양한 실시양태가 상기 상세한 설명에서 기재되어 있다. 이러한 설명이 상기 실시양태를 직접적으로 설명하지만, 당업자는 본 명세서에 본원에서 보여주고 설명된 특정 실시양태에 대해 변형 및/또는 변이를 생각해낼 수 있음을 이해한다. 이 설명의 이해의 범위 내에 있는 이러한 임의의 변형 또는 변이도 본원에 포함되는 것으로 의도된다. 구체적으로 언급하지 않는 한, 명세서 및 청구의 범위에 있는 단어 및 문구는 적용되는 기술 분야(들)의 당업자에게 통상적이며 익숙한 의미를 부여받는 것이 본 발명자의 의도이다.
본 출원의 출원 당시에 본 출원인에게 공지된 본 발명의 다양한 실시양태의 상기 설명은 예시 및 설명을 목적으로 제시되고 의도된다. 본 설명은 포괄적인 것으로 의도되지 않으며 본 발명을 개시된 정확한 형태로 제한하지 않으며 많은 변형 및 변이가 상기 교시의 견지에서 가능하다. 기재된 실시양태는 본 발명의 원리와 그 실제 적용을 설명하고 당업자가 다양한 실시양태에서 그리고 고려되는 특정 용도에 적합한 다양한 변형을 통해 본 발명을 이용할 수 있게 하는 역할을 한다. 따라서, 본 발명이 본 발명을 수행하기 위해 개시된 특정 실시양태에 제한되지 않는 것을 의도한다.
본 발명의 특정 실시양태를 보여주고 기재하였지만, 당업자에게는 본원의 교시에 기초하여, 본 발명 및 그보다 넓은 측면을 벗어나지 않고 변화 및 변형이 이루어질 수 있음은 명백할 것이며, 그러므로 첨부된 청구 범위는 본 발명의 진정한 취지 및 범위 내에 있는 바와 같은 그러한 모든 변화 및 변형을 그 범위 내에 포함해야 한다.
SEQUENCE LISTING
<110> CEDARS-SINAI MEDICAL CENTER
MCGOVERN, Dermot P.
LI, Dalin
<120> DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE BASED ON GENES
<130> 065472-000626WO00
<150> 62/339,357
<151> 2016-05-20
<160> 341
<170> PatentIn version 3.5
<210> 1
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 1
cctaaggaag ttctagacta gtgtttcatg gagcccattc ttttaaatta aaagtagcca 60
tttaaaaaaa ttaaagtccc agaaaatgac cattagaata tgcaatttaa aaatagcaaa 120
taaaacaaac taaggttttt ttgaacagat atatagaaac aaaatttcac ttagtttaca 180
atataaacat gcatttcaca ttagcattaa aatgctattg tgatttatct ctctttcaaa 240
tactattgcc tctacttaca caatcatatt tgtcctttcg ccacaatctg cctatttcag 300
caaactgcat cagcattccc tttaagtttc ccaatgctaa agctgccagg acggactgtg 360
aaaaacacaa acatcagatg tactttaagt taatgaaata aaccacaggg aagcaaaggt 420
gaaggctata gataagtgtg tgctttaaag ggcctcaaag caaatcaaag cattacaccc 480
ttttccggtg tgcgatgcca ygcaagacac accagaactg ggactctgac ctgttcctat 540
gaatgacttt gtccccacaa cagtgacaag gcctaggctg ctcttgtgat tatgagatag 600
atgatctgat ggcgtttagt agcctgcacc ttgggacaga gaaaggcaga ccttcagacc 660
tatgacagac taacatttgg aataaattcc tcccaagcag agacagtcta atgtgtgttt 720
gtttattgga gtcaaggaga tgggggttgc tctttgttaa aaaaaaaaat agcttgggaa 780
gcttgaggtc ctggaatgag atgacttgag gcgggctttc tgggacagca tgaaacatat 840
ctatctagtt cctgctatat ccccagaacc tactatgtta aatgcataca ggaggggctt 900
taaaattagt cagtgaatga gtggctgagc caatgaatga atatttccca ggccagtact 960
aatccctaca gccaagcttc agacttccaa ttcttccaca g 1001
<210> 2
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 2
ttgtttattg gagtcaagga gatgggggtt gctctttgtt aaaaaaaaaa atagcttggg 60
aagcttgagg tcctggaatg agatgacttg aggcgggctt tctgggacag catgaaacat 120
atctatctag ttcctgctat atccccagaa cctactatgt taaatgcata caggaggggc 180
tttaaaatta gtcagtgaat gagtggctga gccaatgaat gaatatttcc caggccagta 240
ctaatcccta cagccaagct tcagacttcc aattcttcca cagccagaat gtgatctttt 300
atcttgcagg aattgtgata gttaaggtga aaaatgctga atagctaagt atattctctt 360
cattctttgg attttatcgt aattgtagga acatgcccct caccgtcctg ttccccctgc 420
caatttattt tattctgaat ggagtatgga atttgtatac tgctatacca tgaaaacaca 480
gtgtacaaag aaaagccaaa hacagttttt atttttatat cttgaggaca gttgaactga 540
tctgcctatt tctaattttc acaggtaatc cttataatat aatatctaag caattaattt 600
tactaactgt gagaatagag gtcacagttt agaagaaata tggtcttaag tgacttttaa 660
aaaatttggc acacaagtga atgccagtta aaaaatggtg aaaattgaat aaagtctgta 720
atctacttaa catactatac taatgtatag tactgatatt gtactacagc tgtgtaagat 780
gtcaccattg tggtagctag gcaaagaagt cagaggactg tacaacgggc ctctccattt 840
tgcaggactt ttaattctct aagtataaaa tatgtcaaga gacacctgtg cgaagagact 900
ttttttttcc attgggcatt atttcccacc tagtcagtat tctacggaaa aacaatttga 960
agtaatttac gatgacatac atatacaaca gattactttt a 1001
<210> 3
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 3
tcttagatat tgaattatat gctaaggttc tttggaacta gcttcctgaa ttttacacag 60
ttgacatatt ttcattggaa caatcataaa acgaaagatc attaaaatat taaggaaaca 120
aaggttaaag agggaaacgc tgatttcttt actgtaaata gatcccaatt tgcatctttt 180
aaatcctttt ggatttcccc atctggtccc ctccctgtta taggcactaa ataaatatta 240
gaaaacagtc ccttcaaaac atgtagtcct ttccttattt gccctgcctc tcttctaaaa 300
aaaaagaaaa acagaactaa ctagagatta ttggctgcac aaacccatca gcacctgcca 360
gtttttaaat ttcattttgg aaaatcagcc atcacttaag ggacttgtcc ataatagctt 420
cattaaagct ttgtttttta tcaaaagggg gccacatatg taaacttgtg gaagtaattt 480
acctcctcta ctcttgtctt yttatttgat tgcaaaagtt aatgttatta aagttgctat 540
ggaagcatta atgttcagcc tgaacaagag cttgacgaac ttctttatac aagcaataac 600
actctgcaac cccattttat gagatatttt tcatgatgta gacatttact ttcttagcac 660
aagtgatctc ttaagattaa tttcttttcc attttccttc agttttaaat gatgtaatat 720
agtaatcttt ataacatgat cagccaagta taatttgaga agtcagttct gttggcaaat 780
atctgaagga caaaaccaaa gccaccctag ctgaggtttt tgtcccttcc ttctttcatt 840
taccaaaaac cttaattggg ttaacagtag gggaatttta gaaatcatgt tttcctaatg 900
taacctgtga aacaaaagca aaatagatta aggcaagggg aaaaatgaac ttaccaagag 960
tgttcttttt cctaagtaaa aaccacaaat tttatagttt t 1001
<210> 4
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 4
gatttcctgg tggatttttt ggcttgatca gcttaagaaa aatggagttg tcattaactg 60
aggtagaaaa aatgctggta gagcagatta ggggaagatc agcagatcag ccttgacatg 120
ttgaaatcca gaggaagatg ctagaaacat gaattaaata tccctctttt atattcttgt 180
tcatgcagtg tagggtcagc catttaaaaa atttcattta catttctaag tggtaagttc 240
ctgtgtttag acaaaaatat gtatcaagtg cttaaataac ttacaaaata attttaaaga 300
tacactgctc aacatgtatt actttcacac tttatgaatt tctgtaatgt atttgtctct 360
tcacaagttg ttctgtctcc cagttgcctc ctctcccctc caatcttgtt ctggtttata 420
tacgtttatt tttatcttcc aacatggtct cttgacttct tcctaaatta gggatcagat 480
tttggtacta ggaaatttcc ratatgtgct ctgaggcagg caagtagagg ctcagcccca 540
tgtattccca ttactagaag catacccaac cttagtggcc tacaagaaag aaaacattta 600
aggataagga taagtaaacc tctaaggtgt taaggttgaa tgtactgtga tgtgggcaca 660
agaattggag tgcttgtgct tgtttcttga gttttttgtt tttgtttggt ttggtttggt 720
ttggttggca agaagagtgc agagggcacc tttgcttggg aagatggaga cctcagcgac 780
aatcctatat ataaggcatt tgcctcaact tcaagccaaa tgattgagta aataggctcc 840
tgttttcaat ttcgacttcc tactcttttt agaggagaag ttcttaaccc aagatttgtg 900
aggcatttta tatgtaaatt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt 960
gtgtgtgtat tttttccccc aaagtccata gggtgtatga g 1001
<210> 5
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 5
aattgagtca ttattaaaat gtccaatcgt cccataaatg ccttaattaa aaaacaattt 60
attcaaatca ggagttatac cacctacttt tgatattttt ctttcatctg taggtcactg 120
aatttaaaaa ctaccaagta gcaaggtata aggtatacat tcctcatgct aagatttttg 180
taaaaactag ctccaggctt gtattgccaa aatatactca gtgtgtttat cttctttaaa 240
gaaaataata ataataaggc gcctggatta ggagtctgaa aagtaatctc catttagaga 300
ctccacatcc atcagtctct ggctggacca gaaaataggt ttttgtgtag gaatattttt 360
tcagaggatt aaaaatgtga gcgaggggtg ggacacttaa tcctgtgttc tctagaagag 420
tgcatttaaa aggatagata cagttcttgg caaaagcatg gtaagcactt cagggttatt 480
attttccagg aaatacttat yctttttcca aatagttata aacatcagca gaatccagtt 540
cataactttg tgatttgcaa attggttgtg actgagattg gattgaaaac ccagttttct 600
tgctttttga cagttgttca agaaagagag cctttggtgt gctaaagact cttgtgccca 660
tcttggagtg gctccccaaa taccgagtca aggaatggct gcttagtgac gtcatttcgg 720
gagttagtac tgggctagtg gccacgctgc aaggtaagat gttggcagat tgagagttct 780
ggtctccagc aggagtttaa cacttctccc cagctaccat aggtctgtga cagatggttg 840
cttacccttc aaggcctgta tctttcctgt agagcccctt agtggagaga gtcacctctc 900
ttctcccctt ccttagagtt ctcttcctgg gaaactgctg ccccactagg tgcagaggtc 960
caatttagag gcatatacta ggcagtggct tctcaatttt t 1001
<210> 6
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 6
tcaggctaat atctcagaga gtagttaaac tttaggctct tgattggggt tccagggcag 60
gactctgtca ctgaaaggga atcctagttc tcagcatact aggaaaaata gccaagagag 120
gaacttatgc cctaaagaac aaggcatgaa tctaattagc agcactgggg tccaagatag 180
agctggacaa acaacaagga taactcatcc caaattctgg agtgcttatc cagaacttgc 240
taagtgctac ttcctaaaga ccagaacctc caggcagatt tgcaagtagg gggaaagtct 300
aataaaactt taggtaattc tgatggaaaa aggcaagaat aacattcctg tgtttgaatt 360
tataatacag cctaagacat aaagaagtca ttattgacaa tgggaaggaa agtaatttaa 420
tatgcaacat aactcaatcc atgaaataaa tatttattta tgtaatacaa tttgctaaac 480
accaccatta ttaaggagag yactaggaaa aactaccaaa cacagcatgt gaaacagttg 540
ggcacggtgg taaagggcac agactctgga gccacagccg gctaatacac tgcaatattt 600
tatgtttagc aaattatagc tggtctgtgt ataaccagaa gagcggtatc tgggggatca 660
ggatatctaa attctagact tacagcctgg ccctgaatct aactatcaat gttgccttgg 720
aaaaactgct caaacttttg atgtctaaag tttcagactt gtaaacttga gagggttgag 780
gtccaaggtc ccttaaatgt aaactttaaa atgctttttt gggaatcttt caaatcttca 840
agctcttcaa agtgcaacca gactttctcc ttactataca gtctgaacaa ctttgagaat 900
cactgtatta tcttagttta tatagtaatc ctgacctaaa ttttattatt ctcattttgg 960
agacaaggaa atagaggcct aggctagcat ggctaaataa g 1001
<210> 7
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 7
actttctcca caaaaccagg tgaccacacc ttcccctcct accctaccga accacgggac 60
ctaggtcccc aggaacagct gtatgtgtaa gagaaagcca cttggagggg ctaccgtgct 120
gggagtgtgg gtgcgcgtgg gtcccgggga gctatctgca ggctcgaagt ccactttcac 180
ccaagcccct ggcaactggc tgtccgggct gcttcctcac accccggtgt cttcctattt 240
tgccccgatt gtcagactcc acgtagctag atcataatgg ggccctgggc agtgggtcca 300
agcttagaag ctcccgggcc tgacagatct caggaaatga cagctacaca tagaagcgag 360
agctaccagg ggccaatgta cttgagaggc cagtgaaact gagatcttca gtgggtctgg 420
ggtctggggg gcagtaagag cagggaccag ggtcgggatc ccaggagttc gaggctgtgg 480
gcagaagaca gggagagaac yggaacttgg gtagagccat aagctgggaa tgaaggggga 540
caccggccca gggctgtgaa caggggacag tggccactaa ctcaggtaca ggattggctc 600
tctggctctg caactccctg caaaatgtgg tcactgcagt gcccatctta gagagcttct 660
gaggattaaa tgagatcatc tttgcacaga cagcacgaag tctagcctag caaatgtgca 720
ctgaacagta gctagagtga cggaagaaaa agctaggaag cagtcttgtc gggagctggt 780
gcttcagcct gagggcagat caggctgggg aaggctgaga ggggccacag ttccatgcct 840
gcatggaggg aggagaaagg cacaagagac tagaaatttc ctgtttgcct gtgtttccag 900
aaattcattg tacaacacac gaaccccttc aatacctgga taggtctcac ggacagtgat 960
ggctcttgga aatgggtgga tggcacagac tataggcaca a 1001
<210> 8
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 8
tactaaaaat acaaaaatta gccaggcatg gtggcgggcg cctatagtcc cagctactca 60
ggaggctgag gcagaattgc ttgaacccgg gaggcggagg ttgcagtgag gggagatcat 120
gccactgtac tccagcctgg gcgacagagc gagactccac ctcaaaataa aaaaaaaaga 180
aaaaatacac ccagaatctg acctcctctc accatcccat tcaaccaccc caagcctgca 240
atgctgtgtg actggcctca ggctccaatg cctgggcctg tctgtcctct gcagccgcca 300
cagcgatgct ctgtgaagta tcagccagca cctggcactg tcctgctctg aacacttcgc 360
agcctctctc aagcagggtt ccagagcctg aggccctaat gctctcaggc agccagtgta 420
tgcaactaag gagctgctct cccaggatga ggtgcctccc atccctggga gaactgaaca 480
aataatcact ctagtcactt mtgccttcca gggctcaggt gagccccaat gagaaaggct 540
cctccacagg cttccaacta agagtaaggc aaaatctctc cgtgaccttc cagactctcc 600
atgagccagc ccctccgtta tttcttggaa ctcatctacc atcttctctc cctcagtaac 660
tgcactggcc acacggcttc tgtgcaatcc tgcatttgtc ctagctggcc ccgatactca 720
gaatgtcctt cttggctggg tgtgatggct cacgcctata atcccagcgc tttgggaggc 780
caaagcagga gaatagcttg agcccaggag ttcgagacca gcttgggcaa cacaaagaga 840
ccccgcctct acaaaaaata caaaagttag ccagttgtgg tggtgcatgc atgtagtccc 900
agctactcag gaggctgata tgggaggact gcttgagcct gggaggcgga ggttgcagtg 960
aacgaagatc gtaccactgc actccagcat ggacgacaga g 1001
<210> 9
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 9
gccaggctaa gggctgtgtt gggcatatgg gcacaatcag agtaatagcg aagggaggga 60
caagagaagg ctggggccgg ggcatacgat gaccccccga ctcaacaccc agtgccagta 120
ccagtaggac ccagagggtt ggcacagcac aagcacccat gaaggcaggc cctggggtct 180
gttccccgag tgggtggcca tgccccaatc cacagtgcta atgggaggcc ccaggagctg 240
cctttgaagc ccttccccaa acaccacttg ccatgtgagt gtcaaccagg aagtctttat 300
tgagccagaa gagcacccca accccccaaa tccttgagag gctaatggag aacaggggtg 360
gggtctctaa gggggggggc gtagacaggt ggggaggagg ctgaatgggc agagcagaca 420
gtggaggtga ggacctgcca gaaaccgagg aagcccctgc tcctcgtcag ggccaggtgg 480
tcactggtcc tgcctgctca rccaccccaa ggctccagaa tcacccctcc cctcttcctt 540
ccctgtcggc tttgccccag ccccccacct gggcctcccc cgagcctccg atccattctc 600
catatagcag cctgaagggt gttttggaaa gctcagacct gacttgcctc ccagagaccc 660
tcaagaaaca aggtcaaatt cccacctcgg cctgcgagac tcctgtgtgg gcaggcccca 720
ggggcacctt tcccaatggc gacagcctga cctcctccct tgaccaggcc ccctccttcg 780
tcccctaggt ccagaaccag ccagcaagca cctccctcgg tccctgcagt ctcctgctgc 840
tgccgcctac tcatccttcc ttggtctcag cctgagtgtc ccctttttcg ggaagtcttc 900
cctgatgtcc cacacccagg ctgggttaca tggcccctct gggctgccca gtcccaggcc 960
acccctctca gttgttactg gccagggact tcttgtctct c 1001
<210> 10
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 10
agaggactca ccggggctga gtgacaggga taatgggctc tggcctcctc ttggcctgcg 60
gtgcctcttc ctccaggggg gacatggagc tcagggaacc caccaccgag atggcttggc 120
cctgggctga caggcgccgc ttgatcagga cgctctctgt cttcaccacc ttctcctcct 180
tgggctcctc cttgcactgt ttggtctgct ctacacctga gggggaggca gcaaacagac 240
acccagtgcg tcagacccac ctgctccaac ccgaggacct cctgtgtgcc tggctctgtt 300
ctgagccctg tacacacaaa acctcgttta aatccacaca acactgtcct ggagtgggta 360
ctctttttat ccccactttt caatacaact gaggctcaaa ctagaaatgc cattcattgc 420
tggggggagc agcaaatgct acagccactt tggaaacatg atgagcagtt tttgtttttt 480
agactgggtg tcactctgtc rcccaggctg gagtacggtg gtgcaatcag ggctcactgc 540
agtcttgacc tcctgggctc aagcaatcct cctgcctcag cctctcagcc tcccaactag 600
ctgggactac aggcgcatgc caacatacct agctaatttt tgtatttttt tgtagagatg 660
aggtctccat atgttgccca gcttagtctt gaactcctgg gctcaagcga tcctcccgcc 720
ttggacttcc aaagtgctgg gattacaggt atgagccact gtgcccagcc ctcagctgtt 780
ttttttggag acggagtctc actccatcac caaggctgga gtgcagtggc ttgatcctga 840
ctcgctgcag cctccacctc ctgggtccaa gccattttcc cacctcagct tctggagtag 900
ctgggattat agacacccac tgccacaccc agctaatttt tttgttttca gtagagacgg 960
ggtttcacca cattggccag gctggtcttg aactgctgac c 1001
<210> 11
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 11
ccccgagcct tgacactggg agaaagacct tgccaagacc atgcccaaat cccaccatcc 60
aagattcctc tggatgggca acaagcagcc ccgacctccc tccagaggcc tttgtcttcc 120
cgatccaggc ggctggacca cgagggcaac ttgggaaggg ggtggaagaa aactcagccg 180
ccttttacca gagctccccc tgggccaggc ccaggctaag tgctgcggga gcacctctca 240
tgacattctc acggcagcct ccagggggcg aaattacccc tgctaaacag cggaggtccg 300
tgccggtgcc gggacctgtc ctgggtcaca tgtacattct caccgcagcc tccagggggc 360
gacattagtc ctgcggggtt tggttttttt gttctctttt tttttttttt tttttttttt 420
ttttgagaga tggtcttact ctgccgccca ggctagagtg cagtgagtgg cgcgtttctt 480
cctcactgca gccccaaact yctgggctca agcagtcctc ctgtctcggc ctcccaaaga 540
gttggcatta caggtgtgaa ccatcacacc tggccttatc gtggtatttc taaagcccaa 600
atttctagca cctcttaaaa aactgggcca tttttcagct ctgggatgca tcctggccgg 660
gcacacagcg gtggagggtg aggagcagcc atgcctctcc cgggtgcaca ccccttgagg 720
gttaccacag ctcctaccac ccagctgccc tccctcatca cctgggagct ggcccagtca 780
tacaccctgg agcactgcta ttttcttggc aggaggcaga gcagagcctg ctgtcctcca 840
ccgggctccc tccggggtca gacgggggaa ggggagggca agcaggctag aagctgctgt 900
ctgcagcctg gaggcggggt ggccggggat gggttacctg cttcatgatg aggcgggaca 960
ggatgttcat gacgaagccc cccaggcggg ggtacatggt c 1001
<210> 12
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 12
gaccccacat taagaactcc agctcttggc tgggagtggt ggctcacgcc tgtaatccta 60
atactttggg aggccgaggc aggaggatgg cttgaggcca agagttcaag accaacccgg 120
ccaacatagc aagaccccca tctcaattat ttttatttat ttatttattt ttatttattt 180
atttttttga gacagagtct cgctctgttg cccaggctgg agtgcagtgg tgtgatctcg 240
gctcactgcc aagctccgcc tcctgggttc atgccattct cctgcctcag cctccggagt 300
agctgggact gcatgtgcct gctgccacgc ttggctaatt tcttatattt ttagtagaga 360
cggggtttca tcatgttagc aaagatggtc ttgatctcct gacctcgtga tctgcccacc 420
tcggcctccc aaagtgctga ggttacagat gtaagccacc ccatcctgcc aagactgaag 480
ttgttttgtg actggattgt scaatgctgt ctttcgcctc caggccttgg cacaggctgt 540
gccctaagta tgcttgggcc cccactgacc ctgatgccca cctctcctga ctggctcact 600
caccacctcc tcctccatct cctgttcgcc ttcagtgccg cctccactcc gggtgaacag 660
cgccttctgt ttctccgcca tcttgtaggt gggctgcatc tcggggtcgt cccgcagcgt 720
gtccagcttg gggtggaacc actcccactg cgtggtgcgg ttcagagact ccaggacaga 780
caaggggtcc tcaggccgct ggttcaggat cttggtcagc agattcacca ggtgctcgta 840
cctgcctccc gcaggaggag tgggaggaga gggacctcac tcactcagct cactgagctg 900
gctcccatgt gcctggccct gtgcctggtg ctggggacac agtagggaac tgaaaaggtc 960
cctgcccagg tgtagctgac atttatttat ttatttttat t 1001
<210> 13
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 13
gttaacaggt gtgaaccacc gtgcctggcc aacatttgta ttttttgtat tttttttttg 60
agacagggtc tcactttgtc actcaggctg gagtgcagtg gctcggtctt ggctcactgc 120
aacctctggt tcccgggttc aagtgattct cccacctcag actccccaga gctgggatta 180
cacgtgtgcc aacatgcctg gctaattttt gtactttttg tagagatggg gttttgccat 240
gttgcccagg ctggtctcaa actcctggac tcaagtgatc tgcctgcctc agcctcccca 300
actgctggga ttacaggcgt gagccaccag gcccggccac agtcagcctt tgaaaccaag 360
ttggtctgat ttccaagcat gtatgtgtca ccttttgctt tgcggaagct gttttgttgg 420
cagtcttggg tgtggtgttg ggccatcatg gaagttggga agggtaagaa gaggtgagac 480
tttggctagg gcttctcagg ragagagcct gaagctctga agagctggca cttggggaat 540
agccagaggt taattctgac tagattctag gatccgagga aggagcaggt agtgactaga 600
aatcaagttt ggtcagcggc caggggctga accacgtaag gccttttgtt tgttggtttg 660
tttgagacag agtctcgctc tgttgctcag gctggagtgc actggcacga tcttggctca 720
ctgcagcctc tgcctcccgg ttcaagtgat tctcctgcct cagcctcccg agtagctgag 780
atcacaggcg tgtgccacca cgcctggcta actttttgta tttttagtag agacagggtt 840
ttgccatgtt ggccaggctg gtcttgaact cctgacttcg agttatctgt ctgcctcagc 900
ctcccaaagt gctgggatca caggcatgag caaggcctta tatgtctcag gccaggagcc 960
ttgaaggttg tggtgaggag tctgagcttc cccctgtggg c 1001
<210> 14
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 14
gttcactggt gaagatgttt ctggctccac ccacctgctt cgtgactcgg tttctcaggc 60
gcagctggct tggctgcgag cccagaccag gctccacctg ctgctgcttc ctgagcctgc 120
tctgcggtga atgccaaaca ggagccaggg ccaggctcca cctctgccca gtaacgttta 180
cgctcctgac taaaaccgac tgtctctgcc ctcgagaagc tcacagccct gccagataac 240
ttttctgcaa agtgagatca cttttccaca gctggaccac cttgagaatg gggctaaaaa 300
tctgtttcct cccaactaca agcctgttat ccccattttc caggtaaggg ccccactgaa 360
cccaaatggc agataggtgg ggattaacat acacttctct ctcccgttta tcacgaaaat 420
gttctgtaat ccaaaaatgt caggggcaga aagaaaaaaa gtggtttcaa atcctgctgc 480
aaactggaag agcagacctt ytaatctcag gtgctagtct gtcactgagc tgcttctcat 540
gtgggcagac ctgtgcctct agagagaggg gcaggaagga cttatgttta tgtaatgaca 600
gctaaagagt cccgttagca acactgggaa ggccagctca taaagtgaca gtaacacaga 660
ggtttatgtg cctgagttca tggactcctt gcatcagcgt ggagggactg gaacgtcttc 720
cccattttta ctgacgggcc caaggtcgca gtgagaaagc gagaagtgaa cgcgaaccca 780
ggtctatcag ctccaggctc ctaactgccg ggccacttga cgtttcctca ggagtgacat 840
gcggaccgcc tgcaagctac acagcctggg tcggcccggg gtgaccaccc ttcgggcttg 900
gcacactctg aggtggagca ggttggggaa gagctggagc tggggacaca gccttgcccg 960
tgggtgggca gggcctggtg ggctcagggg cctcaccggc t 1001
<210> 15
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 15
aggcagcagt gagggaggcc tggaggggca tgaggggaac tatagccacc aacagctcgg 60
gctgcggtgt ttgaaccctc gctgcagacc acacacacac acacacacac acacacacac 120
acacacacac acactctctc tctctctctc gctctctttt tttttttttt ggagacagag 180
tctcgtcgct ttgtcactca ggctgcagtg cagtggtgtg agctcgactc actgcaacct 240
ctgcctccca ggttcaaacg actctccttc ctcaacctcc cgagtagctg ggattacagg 300
catgcaccac cacgcccggc taatttttgt atttttagta gagacagggt ttcaccatgt 360
tggccaagct ggtctcgaac tcctgacctc aggtgatcca cccgcctcag ccccccaaag 420
tgctgggatt acaggcgtga gccacctcgc ctggcctgga ccactctttc tctatgtggc 480
cccaggaagc cagttcacct rtctgagcct cagtggctgc acccaggaaa tggggagact 540
catctggcct ttgttgcagg gtggcagtga agcctggtga caaggtctgc agcacacctg 600
ctgcagtgcc tggcgcccag cagggcctcc agactgggaa gccactgtga ttccactccc 660
gagttggtca tcggtttgga ccagggtgca gagggaaggg cacaggctgg caggatctgg 720
cttcaaatcc aggacctgtc ccctggccca ctcctagcct ctctctccac ttccctccgg 780
gtgcctgagg ccccaacctt aaaaaattcc tgtccattca tccaaaatcc agctccaggt 840
tgggcacagt ggctcctgcc tgtaatccca gcactttggg aggccgagta aggtggatca 900
cttgaggcca ggagttcgag atcagcctgg ccaacatggt gaaaccccat ctccactaaa 960
aatacaaaag ttatctgggc gtggtggcac acgcctgcaa t 1001
<210> 16
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 16
tcgctttgtc actcaggctg cagtgcagtg gtgtgagctc gactcactgc aacctctgcc 60
tcccaggttc aaacgactct ccttcctcaa cctcccgagt agctgggatt acaggcatgc 120
accaccacgc ccggctaatt tttgtatttt tagtagagac agggtttcac catgttggcc 180
aagctggtct cgaactcctg acctcaggtg atccacccgc ctcagccccc caaagtgctg 240
ggattacagg cgtgagccac ctcgcctggc ctggaccact ctttctctat gtggccccag 300
gaagccagtt cacctgtctg agcctcagtg gctgcaccca ggaaatgggg agactcatct 360
ggcctttgtt gcagggtggc agtgaagcct ggtgacaagg tctgcagcac acctgctgca 420
gtgcctggcg cccagcaggg cctccagact gggaagccac tgtgattcca ctcccgagtt 480
ggtcatcggt ttggaccagg ktgcagaggg aagggcacag gctggcagga tctggcttca 540
aatccaggac ctgtcccctg gcccactcct agcctctctc tccacttccc tccgggtgcc 600
tgaggcccca accttaaaaa attcctgtcc attcatccaa aatccagctc caggttgggc 660
acagtggctc ctgcctgtaa tcccagcact ttgggaggcc gagtaaggtg gatcacttga 720
ggccaggagt tcgagatcag cctggccaac atggtgaaac cccatctcca ctaaaaatac 780
aaaagttatc tgggcgtggt ggcacacgcc tgcaatccag ctactcagga ggctgagacg 840
ggagaattgc aggaacccga gaggttgagg ttgcagtgag ccaagattgc accactacac 900
cctagcctgg gtgacagagc tggactccat ctcaaaacaa caacaatgac aacaacacca 960
ccaccaccac acacacacac acacacatac acacacatgc a 1001
<210> 17
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 17
tctgattttc ctgtcgcttg gccacctcga ctcccccgaa tcctgtcccc tccaccttca 60
aggagctgcc acctgccctg gctcctgact ttgaacacat cccagagccc ttggccgagt 120
cccatcttac tgactgggac ttggtggacc caaggctcgc ccaatagagg ctaaaacggt 180
ggcccaggcc cctgcgggga cacaggattg ggagtggtac agggatgccc gggaggcgag 240
tgaggaagcc aggccatcct gccaccgtct ccccagcacc aaggctcgca ggttcagccg 300
ccagcacaac cgcatcgtga agcaggacgg ctccagcagc gaggctgagg actgggagac 360
gccaaagccc ttctaccagc tgctggccga gaaggccttg ccgctgcccc cgcacctcca 420
gtgagagggc ggcccctcgc ctcgctcccc tcacccctca tggcaaccgc ggctcttgct 480
ggaagccagg acccatcgat kaacttgtcc ctcctgggcc tccagcccct gagaatgcag 540
gtcccatggg actggggagg ggggcactga ttagccccaa ccgctgggca catttgcctg 600
gagcaccaga gtcacccaca gctgccttga ttctccccca ggcttaggaa ggaaacccaa 660
aatgaaatgc ggggtgtcgg aaggtgaagt ttacccaccc ctctcccctt cccttcccca 720
ccccagagcc actcggttgc aaccctgttc atgctcacct caccctactc ctccctctcc 780
tgttctattt ttagactatt tattgtttta aataaaataa agcaagtgga acctttgtta 840
ccagcaagag agacaagggc aggccctcct gcgtccccct gctgccccac tggggtgctc 900
cgtccaccct catctggagg cctgtggctt gcaagaggcc tcagtgccac cccctcccca 960
gccactctgt gcatctgaat gcaaacccct cttcccctcg g 1001
<210> 18
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 18
gcctggccca cataacataa tctataatat aatcttagta aatacaaatt cagcatagtt 60
taaggtaaat aatgaaacat ttcagcatgg tctgcctgcc ccaccccacc agcccctctc 120
acccagcttc atcttcttga gtgtggagtc cgagtcatcg cggggccgct tgcgggtgtc 180
cttgctgctc ggcatgttgc gggcgatctc ggcctgaggt gtgcccaggt ccaccagcag 240
ggtggtgatc tgggcctgga actccaagga agccgggtgc ttcagcacac tcaacaggtg 300
cagcttcaga ttcttacgca cactgctcac ctgcgatttg gccagcgtcg ggggcaggtt 360
ggctgtgagg aaagtggcag gagctgtgtc ttgtggaaga tctcatggca tgctgccagt 420
cttaattctc aaccccaaac ttgggcagtg gtcttgcagg catctactag aaaagttcct 480
tcaccctcag atctaacgtg hggctttccg ccttacaagc tgatgcttca aaccctgggg 540
gtctccatca gtatcagtca atcttaaaga gaaaaactca ccctctcttt tagtaaatac 600
atacaatttc gtcctcctcc atctctggtc tggaaattca catatgcttc gcttggggag 660
ggttataatc accacttttg cctccagaaa cccccaactg aactgctgca acagctcact 720
gctagtctcc ctgacgccag gatgactttc taatggtcac cctgataagt gagcctcccc 780
tgttccacag tgaaaaagga tgcctgtaat tctgcctgcc tagcatccac tgccccttcc 840
tcagccaaca acacaaccca ctctccgtta agggagaccc cccttctcca gtctccttcc 900
gagtgggcat gagacctggg gccagtgaga ataccacatt cccttggcca ctgtaattgg 960
ctcagagact ggctcataat ctctgctcag ccaatcagaa a 1001
<210> 19
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 19
ttgcagtgag ccgaaattgc gccactgcac tccagcctgg gtgacagagc aagactccgt 60
ctcaaaaaaa aaaaaaaaaa gaaggggatg gatgggaagg agtttggaaa agcacaagga 120
gctgttagct attgtgttga tcggcacaaa tgaatcaata aatttgctct tccccaactc 180
tccacccctc accaacaccc tattgcaata ttctcaattc ccttcccaag ggcctcgggc 240
aaaaatggag ccctcctggc tagactccat ctcccagcgc gcccagcggg gaagcaccct 300
gcgcttgcgc tgccaagtcc tccccggctt tgtctcccgg gagttcgagt cgttcttttc 360
ctccgcccgc ctaatttgct tcctacccca cctccaagct tgaccgtgct gccttctggg 420
ggatgtagtc cgtggctgcc cggacttcaa ttcccagcgg gcttcgggac gagaacccgg 480
aaggggaggc tggagaggag ygagtggggg aaacccgcgt agccgaggga gatgcagcgc 540
gcggcgatgg tgagagccca ggcgcgggcc gggggcgctg gagagtcggg acgggggttc 600
gggaccgggt gacgaggggg aagaggcagg ggcgaaagaa ggggctgggt gaggggagat 660
tgcctggggg agaggactgg gaggaatggg agccggaggt agtagtagaa gaatggtggc 720
ttggggaggg gtcttggagg tggggtggga gtggagcttt ggaattgatt gtaaaggggc 780
tcagagctgg ggaagtgggc cccgagttgg agactgggct ggacatccag gtagaggccc 840
tgaaggggtc gatttcgatg ggggcttaac ctgcggcgag ggtatgagga tcagggttag 900
gatgagtgag ggggtctgga agctccaagg gacaggcgaa cggtggacgc aatgggttgg 960
ggcctctgga tcggattggg ggcaggaagg caagttgagg a 1001
<210> 20
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 20
cactcctggg gagagactcc ccgcccctgc cacaagagcc ccaggtctgc agtgtgcccc 60
tcagttgagt gggcagggcc gggggtggtc cagccctcgc ccggccccca ccccagctgc 120
ccttgctatt gtctgtgctt ttgaagagtg ttaaattatg gaagcccctc aggttcctcc 180
ctgtcccgca ggacctctta tttatactaa agttccctgt tttctcagcg ggtctgtccc 240
cttcggagga gatgatgtag aggacctgtg tgtgtactct gtggttctag gcagtccgct 300
ttccccagag gaggagtgca ggcctgctcc cagcccagcg cctcccaccc cttttcatag 360
caggaaaagc cggagcccag ggagggaacg gacctgcgag tcacacaact ggtgacccac 420
accagcggct ggagcaggac cctcttgggg agaagagcat cctgcccgca gccagggccc 480
ctcatcaaag tcctcggtgt kttttaaatt atcagaactg cccaggacca cgtttcccag 540
gccctgccca gctgggactc ctcggtcctt gcctcctagt ttctcaggcc tggccctctc 600
aaggcccagg caccccaggc cggttggagg ccccgacttc cactctggag aaccgtccac 660
cctggaaaga agagctcaga ttcctcttgg ctctcggagc cgcagggagt gtgtcttccc 720
gcgccaccct ccaccccccg aaatgtttct gtttctaatc ccagcctggg caggaatgtg 780
gctccccggc caggggccaa ggagctattt tggggtctcg tttgcccagg gagggcttgg 840
ctccaccact ttcctccccc agcctttggg cagcaggtca cccctgttca ggctctgagg 900
gtgccccctc ctggtcctgt cctcaccacc ccttccccac ctcctgggaa aaaaaaaaaa 960
aaaaaaaaaa aaagctggta taaagcagag agcctgaggg c 1001
<210> 21
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 21
tcaggtgcat tggagattct taggagtgtc tcttgggggt aatattttat tttttaaaaa 60
atgaggatgt cactcttacc caggttggtc ttgaactcct gggctcaagc aatcctccca 120
ccacgggtct ctcaaagtgc tgggattaca ggcgtgagcc accgcacccg gctttttttt 180
ttttttttaa acggagtctc actctgtcac ccaggctgga gtgcagtggt gcaatttcag 240
ctcactgcac cctccacctc ccgagttcaa gcctcccggg tagctgggat tacaggcacc 300
gccaccatgc ctggctaatt tttgcatttt cagtagagat agggtttctc catgttggcc 360
aggctggtct cgaactcctg acctcaagtg atccacccac ctcagcctcc caaagtgctg 420
ggattacagg cataagccac catgcccggc ccaaatgggc taatgtttta aacagatcct 480
tcttgtctgc cctgtaggag kacaaattat caggggcagg ggtggaagct ggagcccaga 540
aaggagggga ctgcaggtgg gaagtgatgg tggctggacc aggatggagg ccactgaggg 600
gtatgaagca gtcggatttg aagctgttta aaaggtggag gtgagaggat ttcatgaagg 660
agcacatgag gacacagcag cagagaggac tccttggctt tggatggtgg agagactaaa 720
gatagagaga ttgggttcgg gtagggggag aaccacgtgt gctctttgga aaggttaggc 780
tggcagtgtt tgtaggacat gacaggacac tgagtgtaag ggtctggagc tctcaggaga 840
ggggcgagct ggagatagta atgtgagagg cactgggtcc tgagagggtg atttggtgtg 900
gaccggagca caggtgaggc aaggcaggcc tcgcagctga aactttatat ccagagcagc 960
cagggccact gctggctgcg gagtgaggac gcatatcccc a 1001
<210> 22
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 22
ctcaggcagg gaggtttagt tgcaggataa gagggtctca ggagggctgg gcacggtggt 60
tcatgcctgc aatcctagca ctttgggagg ctgagatggg cggatcactt gaggtcgagt 120
ttgagactag cctgggcaac atggtgaaat cttgcctcta ctaaaaatac aaaaattagc 180
tgggtgaagt ggagcgcgcc tgtaacccca actactcggg aggctgaagc agaagaatca 240
cttgaacttg ggaaggagag gttgccctaa gccaagacca cgccactgtg ctccagcctg 300
ggtgacaggg tgagactatg tctgggggaa aaaaaaagca agagggcttg gggagccaaa 360
tcacgtgttc tggaatcctg actctgccat atcctagctg tgtagttttg ggtaagcgac 420
ccaacttctc tgtgtctcgg tctcctcctc tgtaaagtag gatgagctga tgtgctcatc 480
tccggtgaga attaggtgag dgtgtgcagt gccagcacat gtctgggaag tgaatgctag 540
ctgttgttgg cattgattcc gactcagctg aattagagtc actggttttc catgagggat 600
gatcccttgt ctgactgact gaggcaggca cttcgggtgg ggcccctccc tgcctgggtc 660
ccccacccgc cccactccta gcccctgctc acaggctgag gtcgcaattg atgctggtct 720
gcagcaggta ggccttggcg ttctgcacgg ccagctccag aggctcgggc tcaggcacct 780
gggcactgta gtgtgggaag cccagctcag agggcaagaa ctgaagggca gggtcatccc 840
ttatgtaagg cccgtgctgg gcaccttcag agaactggtc tgtctggtag aggttgaact 900
ggcccaaggg gttgactggg ggctcctgga aggtggggtc cagttgctgg aacaggctgc 960
tttggccctg ctggagccgc tgcagcatta ggctggtggt g 1001
<210> 23
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 23
gtcacacagc aagcggagga actaggattt gaatcccagt ctttctgctt caaaaactgg 60
agcttatata tcaaccttta tgccacctcc tgggactgtc ccctgctttg tcccactttg 120
gggcagctct tactcttaca tccctacaca ctattaaaac aaatgaaggc cgggcacgga 180
ggctcacgcc tgtaatccca aaactttggg aggccaaggc ggatagatca cgaggtcagg 240
agattgagac catcctggcc aacatggtga aaccccgtct ctactaaaaa tacaaaaaat 300
tagccaggtg tggtggcaca tgcctgtaat ctcagctact caggaggctg aggcaggaga 360
atcgcttgaa cccaggagac ggaggttgca gtgagccgag atcgtgccac tgtactccag 420
cctgggcaac aaggcgagac tccatctcaa taataataat aataataata ataataataa 480
taataataat aataacaatg rtaataaagt aactagggta tgttcaggtt gattagctca 540
gggaaaagga aacttgagaa ttaggttcat atgccacttt agaagtctga gcagctatcc 600
caagaccttt cagtattcat taattcaata attctttatt gagcacccac taagtgttag 660
gcattattcc aggacttaag ggatataacc agcgcagcat tatggcttct gtgggcccta 720
tacaatttta ccttcttgat ccccttcttc catagaaaaa tattaacgct gggtgcggtg 780
gctcacgcct gtaatcccag cactttagga ggccaaggcg ggcagatcac gaggtcagga 840
gttcgagacc agtctggcca acatggtgaa accccgtctc tactaaaaat acaaaaattg 900
ggaggcatgg tggcgggcac ctgcaatccc agctacttgg gttgctgatg cagaagaatc 960
gcttgaatct gggaggcgga gatttcagtg agctgagatc g 1001
<210> 24
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 24
ggaagtggag gttgcaatga gtcgagatca taccactgca ctccagcctg agcaacagag 60
taagaccctg tctttttttt ttttttgaga cggagtcccg ctctgtaccc caggctggag 120
tgcagtggca ccatctcggc tcactgcaag ctctgcctcc tgggttcacg ccattctcct 180
gcctcagcct cctgagtggc tgggactaca ggtgcccgcc accacgcccg gccaattagt 240
ttttgtattt ttagtaaaga cagggtttca ccgtgttagc caggatgacc tcgatctcct 300
gacttcgtga tccacccgcc tcgggctctg aaagtgctgg gattacaggc gtgagccacc 360
gcgcctggcc atgagacccc atcttaaaag aaatagagtc agatgtatct cactccaaag 420
gctcttgcct tcaaccattc tgtcactcaa ggttcaatag atgtttgttg aatgactgaa 480
tgagctccct ttgttgggac rgttacagga cctgttgatc ttaccttcag aaggtctttg 540
agagtccaga ctctggtgta gcccccaagc taaccttcct gaagtttcaa ttactgaggc 600
atctgtcttg aaatctggga tgatgcccaa ttgctttcta catacaacct ttatactagt 660
aataataagt aacatttata tattacttca tggtttataa ggactttttc ttagcgagtg 720
ccaaccatat gctccaagcc tggtattaga gataataagc ttaaaaagac tgaggctggc 780
tgggtgcagt ggctcacaca tgtaatccca gcactttggg aggccgaggt gggtggatca 840
cttgaggtcg gtagttcgag accaacctgg ccaacatggt gaaaccttgt ctctactaaa 900
aatacaaaaa ttagccaagc gtggtggcac attcctgtag cccctgctac tcaggaggtt 960
gaggtgggag aatcgcttga acctgggagt cagaggctgc a 1001
<210> 25
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 25
gcaaagtgag atcacttttc cacagctgga ccaccttgag aatggggcta aaaatctgtt 60
tcctcccaac tacaagcctg ttatccccat tttccaggta agggccccac tgaacccaaa 120
tggcagatag gtggggatta acatacactt ctctctcccg tttatcacga aaatgttctg 180
taatccaaaa atgtcagggg cagaaagaaa aaaagtggtt tcaaatcctg ctgcaaactg 240
gaagagcaga ccttctaatc tcaggtgcta gtctgtcact gagctgcttc tcatgtgggc 300
agacctgtgc ctctagagag aggggcagga aggacttatg tttatgtaat gacagctaaa 360
gagtcccgtt agcaacactg ggaaggccag ctcataaagt gacagtaaca cagaggttta 420
tgtgcctgag ttcatggact ccttgcatca gcgtggaggg actggaacgt cttccccatt 480
tttactgacg ggcccaaggt ygcagtgaga aagcgagaag tgaacgcgaa cccaggtcta 540
tcagctccag gctcctaact gccgggccac ttgacgtttc ctcaggagtg acatgcggac 600
cgcctgcaag ctacacagcc tgggtcggcc cggggtgacc acccttcggg cttggcacac 660
tctgaggtgg agcaggttgg ggaagagctg gagctgggga cacagccttg cccgtgggtg 720
ggcagggcct ggtgggctca ggggcctcac cggctgctca atgaccctca gcaccgtccg 780
cttgatgtcg gcgatggctt cagtgtacac ggccgccagt tcgtggatca gcttgtggtt 840
ctgaggcagg agggccaggt agaggtacag acactgcttc actgtctcct ccgtccaggg 900
tgctgccacc tctgacaggg caggagcggg catcagattg gcccacactc ttctccaacc 960
ccctcggacc ctcaggaatg tcccttcttg ggcagtggag c 1001
<210> 26
<211> 1943
<212> DNA
<213> Homo sapiens
<400> 26
gctaagggga ggtgggaaac gggctgacag aactgctgtg ttgaggtgag gactcctgac 60
tgtgcgaccc ccattcatgc attcattcac tcattgaatt tttttttttt tttttttttg 120
agatggagtt ttactctgtg gcccaggctg gagtgcagtg gcacaatctt ggctcactgc 180
aacctctgcc tcccggttta agtgattctc ctgcgtcagc ctcctgagta gctgggatta 240
caggtgcctg acaccacgcc tggctaattt ttgtattttt tagtagagac ggggtttcac 300
caagttggcc aggctggtct cgaactcctg acctcaaatg atccacccgc cttggcctcc 360
caaagtgctg ggattacagg tgcgagccat tgcacctggc ccactcattg attcttttct 420
tttttttttt tgagatggag tctggctctg tcgcccaggc tgaagtgcag tggctcactg 480
aaagctccgc ctcctgggtt cacgccattc tcctacctca gcctcccaag cagtggctta 540
cgcctgtaat cccagcactt tgggaggctg aggcgggcgg atcacgaggt caggagatag 600
agaccatcct ggctaacacg gtgaaacccc atctctacta aaactacaaa aaaaatagcc 660
gggcatggtg gcgggcgcct gtagtcccag ctactcagga ggctgaggca ggagaatggc 720
gtgaacctag gaggcagagc ttgcagtgag ccgagatcac gccactgcac tccagcctgg 780
gcaatagagc gagactccgt ctcagaaaaa aaaaaaaaaa aagccaggca tagttgtggt 840
ggtatgtgcc tgtagtccta actactcggg aggctaaggt gggaggattg cttgagccct 900
ggaggtcagg gtagcagtga gttatgatct catcactgca cgccagcctg ggcaacaaag 960
caagttgcta tgtcttaaaa gaaaaaaaaa gctgggcatg gtggctcatg cctgtaatcc 1020
cagcactttg agaggctgag gcgggcagat cacctgaggt caggagtttg agaccagcct 1080
gaccaacatg aagaaaccct gtctctccta aaagtacaaa attagttggg cgtgatggca 1140
catgcctgta atcccagcta cttgggaggc tgaggtggga gaattcgctt gaactaggga 1200
ggcggaggtt gcggtgagcc gagatcacgc cattgtactc cagcctgggc aacaagagcg 1260
aaattctgtc tcaaaaagaa aagaaaagaa aaaaaaaaaa aaccagccag ggcgcagtgg 1320
ctcatgtcta taatcctagc actttgggag gccaaggtag gcagattgtc tgagctcagg 1380
actttgagac cagcttgggc aacacagtga aacctcatct ctactaaaat acaaaaaatt 1440
agccaggtgt ggcagcgtgt gcctgtaatc ccagctactc aggaggctga ggcgggacaa 1500
tcgcttgaac ccaggaggtg gaggttgcag tgagccgaga tcgtaccact gcactccatc 1560
ctgggtgaca agagcgagac tctgtctcaa aaaaaaaaaa agaaaagaaa agaaaagaaa 1620
aagaaaaaaa agaagaaaga aagaaaagaa aaaaaaatgc ctctgtcccc aaaggtttct 1680
gatgggatta tccgctaata tctgttgaac caatgaatgg atggatgaat gaacgaatga 1740
atrttagttg cccagcagag agtaagagct tgatgtcagt attgcagggt catgcgtgag 1800
ccccctgctc ctgccgtttg tgagaggcgg gagtcccggc gctcacctgc ggcaggatgt 1860
gctgtgtgtg atgcacccag ttggccatgg agtcgaccag ctccagcacg gggatgccct 1920
cgaagtccgg gttctcctcg tag 1943
<210> 27
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 27
aacactcttc actgaacctc tttttgcttt ctttctttct ttctttcttt ctttatgaat 60
gagatggagt cttgctctgt cacccaggct ggagtgcagt agcgcgatct cggctcactg 120
caactgctgc cgcctggatt caagcaatta tcctgcctca gcctcccgag tagctgggat 180
tacaggcaca tgctgctgcg ccaggctaat ttttgtattt ttagtagaga cagggtttca 240
ccatgttggc caggctggtc ttgggctcct gacctcaagt gatctacctg ccttagcctc 300
tcaaagtgct gggattgcag gcatgaccca ctgcacctgg cctcttttgt tctctggaca 360
gggtgccagc tctgctgctt cttagccttc tcccatggtg tttctctacg gggaatacac 420
acccctccca cctcaaaacc ttgtcctgta ttatgctgac tcctgccctc ccctcagttc 480
tcagcctagg tgcttcttgc rcagggagcc cttgccttgc ctggctcctg ctgtggctca 540
cagtgccctt catgttaccc tctcaagcac tacactatat aattatttgt tttctctgtg 600
acttccagaa gaggctgggc cccaggagag caggcccaag tcggtcttag gcactgccat 660
ttccccagta ttggcatggg catggaaaga atgcttcttg agttaatgat taaggagagg 720
ctctcttcct gggcatccca caggtcctca tcagcatggt gtacctaccc gaggccatgc 780
cagcctcctt ccaggccatc tacacccccg tggagtcagc aggcacggaa gcccagatca 840
agcacctggc tcggctcatg gccacacaga tgacagctgc cggactggga ccaggtgagt 900
gtgtcctggc cctaacctgg gccagggatt ggcacttgtg gcttctgggt tctccttact 960
ggaagagcaa cttctcgtgg tgcagttgaa aatcatgtgg g 1001
<210> 28
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 28
cccaacctaa tcttttccat agtattgggc ttgaaccaga gacttacagt gtgcaggatc 60
ctaataatcc agcccaccag cagtcctctt cttataaaga cacctcttct cataaggaca 120
ccataatcag taatcaggtt ttgctggctg tggaagtact ctggacagat tagataacag 180
tatgtatcaa tgtaaatttt tgaagctgat actgtgtaaa tgtaagggaa tatctatttt 240
tagaacatac acactgaaat gtttaggacc atattataag taagtactta taaatgtact 300
ttaggaccat attataagta agtacttata aatgtacttt aggaccatat tataagtaag 360
tgcttataaa tggctcagaa caaacaatta tgtatatata tctgtaaata tacacatgga 420
gagagtgagc atacatgcac actgtgcaaa tgatgaatgg ggtaaaatgt taacagtgaa 480
tctcggtgac ggatgtatgc rtgttccttg tgcctttttc tttgcaagtt tctttaagtt 540
tggggttatt tctaaagtta ggattttttt caagagtaat aattaggatt cacttatatc 600
ttttaggttt ttaagaacct acaactattt atggagaaca agcagcccga ggatgatctt 660
tttgatagac tcaatgtgag tagatgaagc acacaatgtt gaagggagtc ccagccagag 720
cctcacagta cctaaagggg agggttgctg gcagatgact tgggctctcc ctttagcctg 780
gcctgctctg tggcatccca tacactctct cttcctccct ctgagtccac ggtgaatctg 840
tagtcaagag aagacacatc tgctgcagaa caactgctaa agcactcagg gtggggggta 900
gatgagccct accttttatc cttccctgct cctgcagagc tttcccttca ctgaatgccc 960
agccacccct gctggagacc caaaacctgt ccctgatatc t 1001
<210> 29
<211> 801
<212> DNA
<213> Homo sapiens
<400> 29
acaaccttta tatcaacttt ttttcctcta acaatgaaca atgaaaacaa tttgtgctcc 60
atctttaaaa atgtgtgaca caaaaatttt ttaaataaaa ataaatatgt gataaacatt 120
cctgaatgcc tagtgtgtgc cctggcgctg tgctctgcat ttaatttgga tcagcagttc 180
tcagccttgt ttgtacatta caaccaactg gagaggtttt taaactccca gtatccgggg 240
catcagtatt cgtctagggc acagtgattc taacacacag tcaaggttga gaaccactta 300
tttaattcat cctgtaaatc ctcacaatag aatcctgcaa ggtagctttt atcaccacct 360
ttgccgatga aattgaggct caaagaggta aattgatttc rgcatctgta gccccaacct 420
gtgacctctc cttccttcct tctcgggctc ccttcaggga tttcctgatg ttacagaaaa 480
tggtatgtat gacgctgccc tcctggccac cttgacatag ctctgctccc aacagggctc 540
ttctgagata gcagccagac actacctggg atcaggactg atactaaatg acttctgcca 600
aaatgaggac aactgaggcc agtcacttcc aaacaggttc tgtcaccctg agtcagaata 660
atggcagcta cctctcctcc tcaccgccca gtcgtttcta agcctggctc gtcgccgttg 720
ctgctccgcc aagcctttcc tcggtgccct ctctctttta gaacaaatta cttcatctcc 780
aggcccttct cagggcagct t 801
<210> 30
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 30
cttcttgttc atcataaata atgattaact tagaatgtac ttctcccctc tcttaaaatg 60
accaatataa aagactactt attaaaagaa tatatattat aaaaatacaa gagtaataag 120
ttcacagcag cacaggataa acaggaaaga caccatcaga atagcatgag gacttctggg 180
ccaaagggag gggaaatgcc atcaggactg actgaatgac agcaatacta agacgtaaag 240
gaaatttcaa tttgaaccaa gcaaaagaag gaaactctaa aactgtgaat ataaccatag 300
aaccctaggg gggaacaaac tcaaattcag agataagtga agctggatgt agaagtagaa 360
gtgagcccag gactgtcagg agaataatta gaggcctatg gaacagctgc atcctccagt 420
gttctcagaa aggctaaggt gtgagaacag ctctctgtaa taaagtggag gatcagctgt 480
gggggaacca cccacacagg ygctgggact acagaatgaa gaaacagcac cacaaatgac 540
aatgcacaca cccacccaga aggcagctga ctgaatccct ggacgtatat ccctggtact 600
tagcaggacc agcactcctg tactctgaat ttacttctgg aagaataatt cccacttgtg 660
ctgagagaac ccactacagt taccactcgg atcacacaaa gagttctcaa tcctggatgc 720
acatcagaat catctgctga gctttttaga aataccaatt gcctgggccc caccgcaatg 780
caactgaatc agtatttata gagggaagag ggatctaggc atttgtattt aaatattctc 840
cagataattt aatgtgccct taagtaataa caaataaaaa cagcaaagga agcagaaaat 900
aattgtagta ttctctgaaa gatctattaa gataccattt caaagatcta tggagatact 960
aagggagagg aacaatacta aaaagttatt agtggggaat a 1001
<210> 31
<211> 1093
<212> DNA
<213> Homo sapiens
<400> 31
cagtgatgtc tctgagcatc agtggtgtct cttctcagtg gcttacagct ccagacatca 60
catgcagacg tgacaatgtc taatggagaa ggggcacatt ctctcccaat tctactcaat 120
gagaaaccct ttccttcctg gaggtccttc agcggccatt cacacagatc ccactggcaa 180
gactggatcc catgctgttc ttacaccagc catttccaag agaatgaggc caccataact 240
ggcttaggcc aattggtagg acccttcagg aggcagaacc tgggaaccta ggcagggctc 300
tgcccacagg aagaagcagg tgagcgtgtg ggggtggcgg rtggttgtca aaacccaata 360
tacagggaac attacaggaa gagtcactta ctttacaatc atgtcatttc ataaacattt 420
cttgacataa ttagggaaca agaggcagca tgaaggagca cagcttccct gccattcccc 480
ccgccacagt gagacgcctg caaggacaca gacacagcct ttccatcagc cttcctctgt 540
ggatccccca tccacactga gccagcaggt caatggggac aggttccatg ctgttcagag 600
aaaccagcac tgtacacagt ggggccctgc atccactgca ggggtggacg cctcagccag 660
cccaggactg tgccgtcatc cctgagactc actgatcctg atgtgagact ctccccgaca 720
ggggcttcca ggcatggctc tatgcagggt catttgtggc cacactatga cgtgggcgat 780
cccatttcta cacatctaaa ttccccaggg caggcagcat gtggtatctc actccctcgg 840
ctctaacctg gttatgggaa gttgctaggt aactgcttcc cacactggag gaggcttagt 900
taccatggaa agtccagatg ggtggggggg cacagaggaa gggagcactg gctggggggt 960
ctgcagctgg gattctgtcc ccactctctc ctgagcccct ggacctaagg ggagtctctc 1020
aacccctctg ggcctcagtt tcctcctagt aaaatgaagg aaaggctggg tcacttcttg 1080
ctctaaacca ctg 1093
<210> 32
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 32
ataataataa tagcccacat tattgatact gacatgtaga taggtgaatc caatataaaa 60
tgataggagg tatgaaagaa gttggtgagt ttggaatatt atttgactgg ctataatata 120
gagtaatggg gtgggagcca gagggaaatc gaaaaggtga cctggaaaac attgttcagg 180
gccttgaatg ctatgttgag gtattttgac tttataaaat agtgggggac aaactacaag 240
tattttatac attgaggtat agtttatgaa gtttttttat atgtatagct tatgtaaatc 300
tcaaaggaat gctgagaagt aggcgttatt atcccattgt acaggtgaga aagctgagtt 360
tgtggaatat gcatacattc tacattattg agcacctgct atttgccaag cactatgctg 420
agctatgaga ctagaaggaa gttgtagttt aatactctaa tagaggaaac aggaataaat 480
cagcaattgt aagtagttgc yataataaag gcaaacaatg ttacgggagt gaaaggggga 540
cttgtctata tttgcatagt cagggaaggc ttcctggagg aggtgagctt aaactgagtt 600
tggagaaaca aatagattac agtaattgcc cagagatatt taactaggaa gcagtttacc 660
tgaaacttga acccaaatct cctgtgtcta gctctttccc ctactccaag gaccaatctt 720
tggtccttga ttttaagctc tatcagcaac tcagtcacaa gtggacttgt tatgtttgga 780
gaaggtcaga gattccaatt ttttattttt aaattcattc attttctcct tttaaaatct 840
ctgtgtgtgc tcaaagagta gattggaagc agaggaactg gaagaagaac agaatgttct 900
gatagttcag gcaataagtg atgaaggcca taactaaggc agaggtcatg ggcatagtgt 960
gaatctccac tctgttcact ctcctcacac atatactttt a 1001
<210> 33
<211> 2093
<212> DNA
<213> Homo sapiens
<400> 33
tggttttctc ctttaatttt ttgaacttga ggttctataa aagtgaacac agtttgcttc 60
acctgacttc ccggacacca tttctccttc tcatctcctt gactcatccg ttctcaattc 120
tatgacctct caactttgaa ggagcccatt ctctaacctc ttgtcttctc tatctatatt 180
cactccacag gtagtgttat ccacttgcaa agcggtaaat actcttcgat tctgacaact 240
ctcaaggttt tctcttcagc ttctcctgac ctccaaactc gtgtatctaa ctaccttgac 300
ctctactcct ggtcttgcct tccaaacctt ctctcccacg gtctctcctg tctcagtaaa 360
tgacacatcc ttgcttctag gttctcaggc catgaacctg ggagtcacct taactcctgt 420
gtttgtctct tatagctctc atgatatcca tgagcttacc tttgaaatac aaggtggcta 480
cccagtctag ataataaatg atttattgat gctacattct aatacaagat acaataacat 540
tatctatgtt tctagacttt atgatcaccc tgtatattca aaatccaacc acttcccacc 600
actyacatca tcctgtttta agccacaacc atctctggtc tggactatga aagtagcctc 660
tttttttttt tttttttttt tgagatggag ttttgctctt attgcccagg ctggagtgca 720
atggcgcaat ctcggctcac tgcaacctcc gcctcccggg ttcaagcgat tcttctgcct 780
cagcctccct agtagctggg attacaggca tgcgccacca tgcctggcta attttgtatt 840
tttagtagaa attgggtttc tccatgttga tcaggatggt ctcaaactcc cgacctcagg 900
tgatccatcc gcctcagtct cccaaagtgc tgggattaca ggcatgagcc aaccatgcct 960
ggccaacagt aggctcctaa ctggtctctc ttcttctgtt cttgctccct tgctatctaa 1020
tttcagcaca acagccagag ctaccctttt aaaacttaaa acccaagtca gatcatacta 1080
ctccccagtt caaaatcttc cattggcttc catctcactc agagtaaaat ccaaaggcct 1140
cgccatggca acaaggccct acatgttctg ctctctctct gatctccatc ccaactcctc 1200
tccacctcac tcacagtgtt aaacatgtct ccacctgaag tctttgcact tgctagtccc 1260
tatacctgca aaagctattt ccccagatgt ccatccagga agtactggct tcttcacttt 1320
gttctagact ttgctcaaat gtcctttgat ttcccaacgt aaaatcgcaa cccccatctc 1380
agccacactc cctgtggctc ttgcatcatt ttatttttct ccctaacagt aggaccatct 1440
gatgtacctt ctgtttctcc ctttaccaga atgtaagatc caggagggca gagattatgt 1500
tttgttcact gatagttttc cagcacctag aacaggacta acacagagta ggtgttcaaa 1560
ctttatttat tgaataaatg aaacgagaat gtctgaatgc acactattaa ataagaagta 1620
catattttac cataaagtta aattgagcat aattatggca agaagttcag atattggcca 1680
ggcgcagtgg ctcatgcctg taatcccagc actttggggg gccaaggtgg gcagatcacc 1740
tgaggtcagg agttcgagac cagcctgacc aacatggcga aacctcagct gtcctaaaaa 1800
tatacaaatt agctgggtgt ggtggcaggt gcctgcaatc ccagctactc gggaggctga 1860
ggcaggagaa tcatttgaac ttaggaggtg gaggttgcag tgagccaaga ttgcgtcact 1920
gtactctagc ctgggcaacc gagcgagact cagtctccaa aaaacaaaat aaaacaaaaa 1980
acaaaacaaa acagaagttc agatataaac aaatgacccc tcaaaaggaa ttgattaaaa 2040
aaattttaaa caaagtatgg tttaaaaaag aaacttctcc actgtggcta agt 2093
<210> 34
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 34
ctgcacagtt gtacatattg gcagggctca gcttccttaa atgccattgg atcagtaggg 60
aaatggtgat tttccttatt gatttaatgc cagttcctct tttatgaaaa atcccacgtg 120
ctgctcactg gcgtatgtac cataaaaact gaacgtaggg ggccagaaat taagtaagtc 180
actcatgttc ttctccagcc atgtgacgtt aaaccatctc tactttcagg ctggagtgtt 240
caatcattct ccctttaaat ttagcagagt gattattcct cctggtggat tgcacatatg 300
ctcctttgat ctatgaaata ctcattctgg atgaacttta agctcccagg aaatgcatgt 360
aaaatactgt ttataaatcg cgggagaaat gtttcacatt cttattactc ccaagtaatc 420
ataccaagcc tctctctcca agattcgctt tttttcctag aagagggaaa aagaacttcg 480
ggcagtagca ctgtgacaat matcaccacg gtcgtacttt ccatgagttt tacgcagtag 540
gctcacggaa gtgacaatgc atggtcgggc gcggtggctc atgcctgtaa tcccaacact 600
tcgggaggcc gaagtgggtg gatcaactga ggtcaggagt tcaagaccac cctggccaac 660
atagtgaaac cctatctcta ctaaaaatac aaaagattag ccggacgtgg tggtgggcgc 720
ctgcaatcct agctactcgg gaggctgagg caggataatc acttcaaccc gggcggcgga 780
ggttgcagtg agccaagatt ataccactac actctagcct gggtgacaaa acgagactcc 840
gtctcaaaaa aaaaaagaag tgacaatgta ggatacccat tcatcagcaa atatttaatg 900
tgagcaggac aatgtgctaa gtccatagac tgcaaagagg agtgaggctg ggttcccatc 960
ctctggggct tacaaggtag ctggagaagt aaaactcaaa c 1001
<210> 35
<211> 658
<212> DNA
<213> Homo sapiens
<400> 35
tgattaaaca ttcctgaatg caaatgtttt caaatgtcca atgacttccc atcatccttg 60
gtatgaagtc ctaagtccct ggcatgcttt caatgtcctc catgatctgc ccccagtcca 120
atcactgatc ccatctcctg ccagtccatg attgaaccag ttgggtcccc aactcctatt 180
tgcacacacc attctctctg tgtgtcatat atgagctctc tactctgcct agctacttgt 240
ctgcaagact cagttcaatt gtcacctcat ttgggaagct tccactaatc cctcctgcac 300
ctgtctccgt cctaggctag attaggagcc tgccctttgg gttcctgaac cacttgaggt 360
gtggttcctt tatcatgctg atctcactgg tttggctgac ttgtttttcc tacaagactg 420
aactgtctga ggtcttaaga tgggctgtct agtccacact ggatcttcat gctctacaca 480
gggcttgaca cagagtgggg cacaggaaat gtttgttgaa cgaatacaca aagcatatgg 540
atactcctga gagagagrag gtgggcaaga cagccttgtg aagttaagca gcagaaaatc 600
tgaaaacgaa cctggataga aatcaccaat tcctggaagt acagagagag gaaggaga 658
<210> 36
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 36
tggccaccca gacctccttc ctgcgcttca cactcaaaca aggctgttcc ccatgtcttg 60
ggtctgtctt tcctctacct ggatcgttct tccccatggc ctggtctcag cattgagttc 120
tcaaatgtcc ccccttccct caccttatcc gaaggaccca ttccccgtcc tctctacatt 180
ctgtcctatt accctgtctg gtttattttc ttcctagtat tgattactac tggaatcctc 240
atattcatca gtctgctggt ttaatgcctg ttccctttac tggaatgtaa gcatgatttt 300
ggtctttttc tcctctgtcc tgagtaccca gaacaaagcg tggcctatgg aggacactaa 360
atgaacgcat gggggaaaaa cgggttttat tgcagaggga gaccctttgt ttcatacaga 420
tcgtttgtaa acttagatat tttattagca acaaattatg atagagctta caaactcctt 480
gagaatcgct gcggtagtag rtgggggtgg agcttctcta ggcagcattt cagtgtgtcc 540
tagcttggat gctgtggctt cccgagctct gaatctatac tgcttactct gggcttatgg 600
agtgtgtagc agggaatcct tgttgaagga tccccaaacc cttgatagcc atggacagcc 660
cacagtggtc atggagccgg agccagaatg taattcccag tgtgaccagg agctagagtt 720
taagtcaagg cagcaggtat actcaggtgc attttccatt ccctttgagg gaggggtgga 780
ggtttgagcc ccctccacat cccaccccat tggggtgcct ttgtcactct tgacagcttt 840
agagtgactt agatgggaga ttggtgggga ggaggggggg aggggcactg tttgaatcta 900
ccctgctgga ggcactgaat agttttataa gtatgtgtac actctattgt tcaagtgttt 960
gcttaaatca ctgtatcttc ttagaaattt ttgtaacctt t 1001
<210> 37
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 37
gataataacg cctacttctc agcattcctt tgagatttac ataagctata catataaaaa 60
aacttcataa actatacctc aatgtataaa atacttgtag tttgtccccc actattttat 120
aaagtcaaaa tacctcaaca tagcattcaa ggccctgaac aatgttttcc aggtcacctt 180
ttcgatttcc ctctggctcc caccccatta ctctatatta tagccagtca aataatattc 240
caaactcacc aacttctttc atacctccta tcattttata ttggattcac ctatctacat 300
gtcagtatca ataatgtggg ctattattat tataattatg actgaagtag taggagatag 360
aaacaaatgt tgcttttgtc tactaagtgt tttgttatcc tctgtctttt cccctcatcc 420
tagtcaatat tccattaaaa cacaggttcg attacatttt tcaatgccta ctggataaaa 480
tcaccttgta gtatggataa kgttcttcat gatccaactt ccctctgtta tttaaccttc 540
ctctgctgct ccactaatag cctttgtgac agttgtagta actacagtac atgtagtttt 600
tccaagataa taggctggct cagctttcat gcctttacac atgatgtgtc ctttgcctct 660
tacgtcctcc tctactttgt ctatccagtg aactccctgt catcctttaa gattcaattc 720
agatgtaaac tcttctgtga aacctgccct taaatactca gtggcagaat tagatgatct 780
cttctctctt actatgccat acatatcttg ttacaatctt ctctgacggt gcctgtcacc 840
tccactagcc tgtaaacgta tccagcagag ggctgctttt tatctccgag tccttactgt 900
ctggcacaaa gtgggtgctc acggaaaatc agttgaatac atcaacaatt acccgtcagt 960
ggcacctgaa gccatcagtc actggagcta ccccatcatt g 1001
<210> 38
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 38
gactttactg aagcagagga gaaggagatg atcaatctat tcaatatgaa gaaatatctc 60
tgttgctaat acaatatcct tttgaatatc tcccacatct taggccctgg tgaaaatccc 120
tttcaattgt tctgtctacc tcgtagggat gttgtaagaa taaatgagtt aacatagata 180
tgaagtgcct taggaaaaag gctctataaa aatgcaaggc gatatcatga ttagttgttt 240
ctttgactct tgatcatttt cttcccactt cttatacaaa atgtctctca cttatttcct 300
gaagccatct cttttagaac tattgcttcc tagaagagct gaaaatgatc ctagttccaa 360
catatttatt gattcccaga taataacacc cactggtgtt gatgactgac agggttcatg 420
cctaagcttg agtagaactt gccctttttt cctgggtcaa gaaaagtctg caattgttcg 480
aaaatgtgtc agtaagtgtg mttccatcac gatttcttaa ataagtaaca gttgctgctg 540
gataatcctg ggggcagatg attcattttt gtgcccctat caaacaaact caaaacttgt 600
taaagaatct ttataagttg tttgaatcaa acaatagggt cgctaggtcc ccattttgtc 660
catttgaggt atttgcccag cataccttgg tctgtaaaga aatagcacag ccttggctgg 720
gcgcggtggc tcatgcttat aatcctagca ctttgggagg ccgaggtggg cagatctcca 780
aaaataaata ataataatga taataacaca gcctcatgag tctttttttt tttttttttt 840
ttgagacagg gtctcactct gtcactcagg ctggagtaca gtggcacaat cacagctcac 900
tgcagcctca actaccctgg gtttagtgat cctcccacct cagcctctca agtagctgag 960
actacaggta cacaccacca cacctggcta atattgtatt t 1001
<210> 39
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 39
gaaacctttt atatccttac aactattcaa tcttcctgtt caggaaaatg gaatatttaa 60
tatctttcta ataatcaaat attctctata tctaggaaag tcatttttat gtatctcaat 120
caagttttat agttttcttg atatgggttc tacacattga cttacatcca tctacatttt 180
tgatttttat actgggaatg agatggagct gctgctaact ctggagaaac ttactgctga 240
tcttttatct ttggacatga tcctgactgt tctcctaagt gatggattat cttagatttg 300
aaaagtatag gaagtaaagg acaagaggga catgtggggg gatgtagtag agtctgtttt 360
atattcatag tgagaagact ctgaacctcc caggagggct ctaaaggtta aaaaacatgc 420
aaccaaaagc accgaggatt agtaaaaaga aataatgtgc agtaagtgct cagagggatg 480
actcattgca ttggatcatc yttgggaaac cacctactaa gcagaattta gcagctaaag 540
cgttattttt ggtgcacagt ttattgctac ttcctcttgg gaaaaaaaga ttaatcctag 600
ctccctaaaa cacttaagaa tggtcaccct ggcaaaccgg cctgtcaggt aacaatgttg 660
tttccagatc agggcagtgt taggttccct gtagggattt cttcagaaca agggagaagc 720
actttaccac atgttatgga aaggagtata gaccaggaga cagaagatcc agctcttagt 780
gctggctctg taactgatta acaaataaat cccagagtgc aggcaggcca cttaatctct 840
gctcatctgc taaaaaacag atatcacagc ttctgtcgta ctccatatca tggaagaaaa 900
taacacaaaa taataaacca tgtgaatgaa gcagttaaaa ctgctgagaa ataaaattaa 960
cctgctcagt aaaagtaagg ctaccaatca agaacaaata g 1001
<210> 40
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 40
ggcaatcctt gctttttatt accacactgg attgcttctg tacacagcta agttgcctga 60
agcatggaaa cttggacttc tccatctgac acgttctgga agcctcaagg cacaagctga 120
cagttctgct tctacagaaa aactctcaca ctgctctcct ctcaacagta ctgcctgttc 180
ccactactcc acatgacacc tacgagggca ctacatcacg tgagggaagc ttcttcatga 240
gggcagacaa gaggaggcac cacccaggca ctggtctctg cctggcatct attccgaggg 300
ccacctggca cagtttctaa attaaggcat atctaaaatg cttttctacc tttagttttt 360
atttttgcta tatttttgca ctctactata tgcatattta ataaaaacaa ctacaaagtc 420
ctttacttta attcctttac ataatgataa aacacctaga tacccaaaat actacatcta 480
tatattcaaa tctactaatc rtgttacaaa tgcatgcagc ttatttgggg gcttagtcta 540
atttttattt tcttaggtcc atcaatacca tgataatgaa cattagatgc aaaatcctaa 600
cactttctgc cttcagttgt actttcacag gactagtgtg attcagaaat aaataacata 660
catgaataat aatagaaata atttatgcaa atgtagaaca acttgaaaaa aaatcccccg 720
cctgtcaggt gctgttcctg ggggtagctg atgctataaa ttccatgtac taactaatat 780
atttactaca ggtaatagga aaacaaatga ataaaaagtg aggaactatg atatacatgt 840
gtatattttt gcaaacacag gatcagaatg aaaagatata tcatgcactg tgaggtttaa 900
gaaatgtatt actgctggga tttgttttat tattcagact ttaagatcaa actgagagtt 960
gttggtgatc acagaaatat tgctagctga tacatattat t 1001
<210> 41
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 41
cctttccatt taagacatgt ctttgaaaat agactctagt ttaaatgtta gcagatagac 60
tttgaagtaa ttatgaggaa gaacttggga ctgaggatgg tcaaattcta aaacacagta 120
ttggatccaa agacaggttt ctccaccctt taagaataaa tctgtcaggc caggtgcggt 180
ggctcacccc gtagtcccag aactttgaga ggccaaggca ggtggatcac ctgaggtcag 240
gagtttgaga ccagcctggc cagcatggca aaaccctgac tctactaaaa atacaaaaat 300
tagccaggtg tggtggtgtg cgcctgtaat cccagccagc tatttttggg aggctgaggc 360
aggagaatcg cttgaacctg ggagacagag gttgcagtga gccaagatcg tgccacactg 420
cactccagcc tgggggacag agagagaatt tgtctcaaaa aaaaaaaaaa tccatcagaa 480
acgtctcacc tcaatatagc rgccaatgtt gtcccatgta aaagtcaggg cacatggtct 540
attgatatga aaaccataaa tcagaatatt tcccattgaa actgccttag gcacagcttg 600
cacattgtaa tatctctcaa ggcaagaaaa tgacctttca gaatagacgt attctagcta 660
aatccccagg catcccaatc aacaattctg gcttccctaa atttccatct gccagagttc 720
gggctgattc tgggagtctt cttgttttga attctcaatg gggtgttagt gcggttttta 780
acacccctct ccagcctcac ccctgatgtg gctgcatttt ggcagcgagg aaaagtctgg 840
gttagaggtt tgggtttcat gagcccttcc aagaacaaga gcagctaagc tgacacaaga 900
gcacactctc cctaaacagt cttttctgcc acctctccca ctgattttat gtaaccgaga 960
agaattagaa aagtgtgaaa aaagcaagac tgatgtttgc t 1001
<210> 42
<211> 601
<212> DNA
<213> Homo sapiens
<400> 42
gaaaatctgg agatgaatca gatctgttcc ttctctcagt gacactgcag tctagatggg 60
ttcagtacaa atatctctat aatacaaaat agctctcaga ccagtctttg tagaaatagc 120
tgtatgataa ggcttccaat aattataata ataaaaaacc cagttattgt ctgaaatata 180
aacgctcaaa atgcagaaat gttttattca ttgttctgtc cccaggaatg gtgcctggcg 240
tatagtaggc actcaaaaaa tgttagatga tggcagcaac ggtacttcag ggccagggga 300
rccagcaccc atggagagat gcagaggcag aaatggatta ctcaaattgg gaacctgatg 360
ccccctcttc tcactttaat ggagttgtag tagttgagct tcaaagaaag gagcgtcctc 420
cagtgaggtt cctgcccctt cctgggcctc tctaccacag caagagccag ggccagctgg 480
cagttttcac caccctgctc atgtttttct ggagacacca gcttaaccac agccaccaca 540
gatcggaggg tgctggcccc agcctgctgc ctgctggttc ttctccttcc tccctccctt 600
c 601
<210> 43
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 43
tacagtcctg caggctgtat atgaaacaca gtaccagcat ctgctcctgg tgaggcttca 60
ggaagcttat aaccgtggca gaaaggtgat ggggagccgg tgtatcacat gatgagagaa 120
ggaagcaaga gatgggggaa gaggcaccag gctcttttaa acaactagct ctcatgtgaa 180
ttaattgaga actcacttat caccaagggg agggcaccta agccattcat gagggatccg 240
ctctcatgac ccaaacacct cctgctaggc cccacctata acactggaga aaacatttca 300
acatgagatt tggaggggac aaatatccaa accatgtcac tgacctgggt tcacattgtc 360
agtctgccac ttatcatctt gatattcttg ggaagataac tttgcttctc tgagccttgg 420
ttttcttcta gaaaataata aaacttgctt cacaggagtg ttaagaagag taagtgagat 480
aatacttgaa aagcacttaa ytttgcatat gacacacagt aagggcttaa gaattgtcgc 540
catcatcatc aatatcatta ttattctctg cacaataaaa tgtgttggaa tcacagcaga 600
taatccagtt atttggatga gtttttccca cgtcatgggc tgagcagatg agttgacaat 660
gggtgactgt tgagtgtcta ccatatactg gcactgttat ggaagtgtgg gcacagctcc 720
tgagagttgc ctaagtgggg ttatgacctg tattttccta gtcatcctac ttaggaaatc 780
atccccccag ttggtgtaag acagtaggct ctcttataca ctgttgctgg gagtacaaat 840
ggatgcaatc tttttggaga gcaacatggc agtatttttt tacgactttt taaaggcata 900
tttggattga gtaattttcc tttgcaggag aataatctgg atatgctgat aaaatatgcc 960
caacgtggca tggataaata tgtttgaaac acacacacac a 1001
<210> 44
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 44
ggagatattg accactgtga agatctgttt cctcccagct gatgcagaca ggtcctgaga 60
ccaccggaat ggtgcattct caggggcccc agccaggcag ggtgtgcagc ctgtactcag 120
aggaccctga gcttggtttt attttctccc atcagcattt gacactctta atgatttttg 180
aacacgaggc cctgcatttt cattttacgc tggaccacac aaattccata gctgtttggc 240
agccaagcca agggctgagg acagcacctt cctagagggc tgtgcacaag ccaagttctc 300
agcagcaact tttctgagag aaaaccatct agctccaaat cacgtgttca ttatccattt 360
tcttcccacc ttttgccact tctccttttt ctgtggtccc tccctgttta gcaggtatgg 420
aaggtttggg ggagaagcca ctcattttct ctgcatctct tctggccctg tttctacctc 480
caaatctgca ccatagcccc rtcctcagct tccttgtatt tcctgaagct gtgtcctctc 540
tcccccagcc cctggccgca cccatctcag tgtaatggta ccataaaggg gccaaggaag 600
agcctgtttc cttggcagct tacatctccc cctgggattg ccaacatgca ggagtcagcc 660
cttcctgcct cattacctga acagcttccc cttcaatccc tgaaacactg cactggagtg 720
gagtctactt tgaaagtgaa agtgatttag agtctactcc atttcgagaa tttgcatgtt 780
aaccccttgg gctgggcaca gccccatgga gatttgtttc tttcctggcc agtcccctct 840
cctgccaggt ggtctttgct tctttgcagc ccctcaacat gacagcatgt ttgagtcctt 900
tccagcaaga agctgaactc cccaggagtc tgccagtttt ctagaaaaca ttggttactg 960
gctcctttct ggttttgacc attctttact cagggcttag c 1001
<210> 45
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 45
ttaaggggga cttcaaaata aaaaactatg gacacactcc tggagagcag cacggaggag 60
ggatctatga tggtgtaata attgtgagtt tgggctagat atgactgaac aagtaaaggt 120
tgccccaggc atctcacagc gggatgcaga aaagcatcct gatgctaccc agttgaggaa 180
tccaagacat ctcctcccct cctatcaggg agggcacgaa ggggcttcac tctacaggga 240
gggtggaagc acagcagcct tacattgcag ctagggtgca gcaagccaca gccaaggcca 300
gaattctgca gagtgtccca ggaagagaaa agtctaggta gaaatcagcc aataacagag 360
cagaagctaa agagcagaca atgcaacttc caagacaaag acttagcaga aaggactctg 420
aagctagaag cagctgtaac aggggggatg agatggtaat ggttaggaat aaagaagtag 480
aacatgaaga ggggcctttc rccatgctga tagtgataac catttcttta ctgaggagga 540
accagacacg atgtggtaat ctgctttata tactttaaat gtaatgggcc atagccaggt 600
acagtaggag aaccacacac ttgtcctttt ataaaatcca gaatgcaaaa ccttctccac 660
taggtactgt tcatagaatt atctgaacag aaaagacctt tcttaataat ttaagtcaag 720
attctattgc tctacctggg caaatcagta agctacactg cccttatccc ttacaaaatc 780
ctgccttctg tctgggcatg ataacatggt tagacagggt cacatgttat atatatatat 840
gcagagtttt tcattgcagc aaaatataga aatcaacata aatatgcacc aataaagtgc 900
taataaaaag attatgttca tccaggcaat ggaattctat gcaactattt taaaaagggt 960
gtgaagaagt gctctaaata atatgaaaga tctaagtcat a 1001
<210> 46
<211> 701
<212> DNA
<213> Homo sapiens
<400> 46
cacagccact gtcttcacag ggaagcttgg tggccttgag ctaacatgaa ccggtaagtc 60
ctttcctttt taacagcact ttccttggaa gaatttctcg caggccagcc ttacaggctc 120
ctcacatgtc cactcgtgtg aggtgtaccg gcagtagagt tagtcccttg agaggccata 180
tcagggctta ctccacagcc yctgggacga cagcccagtg tttcagcaaa ggagctgctt 240
acaatcttgt ctatattaag gcccctggcc tttcctttaa agaacaggga tccatttaac 300
accaaaacat tttggagccc cctctctcca tccctatcat cagagtcctg ctttctgtgt 360
ccattcattt aaaatatcca taatgggctg ggcacagtgg ctcacgcctg taatcccagc 420
actttgggag gcagaggcag gtggatcact tgaggtcagg agttcgagac cagtctggcc 480
aacatggtga aatcccgtct ctactaaaaa tacaaaatca gtcaggtgtg gtggcacgca 540
cttgtaaacc cagctactta ggaggctgag gcaggagaat cgcttgaacc tgggaggcag 600
agattgcagt tagccaagat tgcaccactg cactccagcc tgggtaacag agcaagattg 660
tctcaagaaa agaaaaaaga gaaaagatcc ataacgatcc a 701
<210> 47
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 47
aactacttgt agttcctcaa atcaccatgc tcactctttc tcactggtct tctctccttt 60
gtcttcttgg aaaactattt cacctgtcaa gattcagccc aaagcatcat gttttgtcaa 120
gtctgtctga atgctttagg cattgctaag tatgcctttg cttctgctca cagcatccat 180
gaataactct attatatcac ttattacact gctttacaac tacatctaca ttcttgttgt 240
tattctccac tacatgatgt aaatattttt ttttacttat attcaagaat taaaagaaaa 300
aaaaacctta ccttttcatg gcaaccaaaa gtactgaatg tgcatggaat tggggctgta 360
gggcagtcta gatcataatg attaggcatc tgaaatccaa aacaaaggct gaaaaatctc 420
ttccttgcat atcattttct agtttgatgc gatcacattt aaactgtatt gtcaatggct 480
gctttgtacc acattggcag ytgaataggt gcagcataaa ccatcaccca caaaaattaa 540
aagaacatct actttcaaaa gttatagaga aaggaaatat caacatctca taatatcccc 600
tccaattatc caaaattcat ttcaagaaaa tgaatttgtt cctcttgctg ggaactggca 660
ccctctagtg gcactttaca gaaaaaacac ctaacaatag ctacaagtgc aaactggatt 720
aagactccca ctatggtcta ggccatttaa taggaaccag tcaactgcat gcactgaagc 780
cactgactac acccatactt gcctcatgac cacctctcaa aaatcatctt tgaccacctt 840
tcaacaatct tcttaacttt tgttaagctg ggcatatttt agctacaatg gggagactca 900
gatgttagaa ggtactttaa acacattaat agaagctcta aaaaaagtct cagtcctgga 960
ttttgggact ctaagacaca ttctctaagg taagatcctt t 1001
<210> 48
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 48
taagtcctgg tgacagttca gcttcacctc taggaccaga aggttccgaa tgccctcgga 60
aagggcttct ccaggggctg ccttcaggcc ctcaggcttt cttaaaacca caaacgtagc 120
caacacctga aaagagaggg aagcttttat tgagaactcc tggcctgaga acacctctta 180
gaggaagttg gctgggactt tccagcctaa ctaccccgaa aacaactgcg ggacccagca 240
atagcatcta ttccctggca ggttcccatt cacaagtttg cacagggctc ttttcggttg 300
taacagtgtg gtcaccctca agtgggaaga cagtgacaat ggggccagcc taaggccagt 360
cctgcagaaa aatgatttct aagctgtgct agactctggt tccaatatgc agccatcagt 420
ttgagcactg cctgggttcc tgtggcccac gatgttgtgc agtaagagat ggatttttaa 480
aaaatgtctc aaggaggaca yaagagctcc tcatcctggc attgatgacc atccatgata 540
tgcccttacc aagccagtct gcatatattg ctcagttttt ctcaaagtat cagtgactct 600
tcactcaagc acatctcacc ttcccttacc tgctgttcct tcactcattt catcaggaca 660
cactcactga gtgtttgcta tttattaacc actgtgagtt gcagaacatc caaagatttc 720
taagaccaaa tccctgctct cagggtactc agcctatgga gaagataaca gtcttttcaa 780
gtattcactc atgcaataaa tatttattga gcagctacta tgcatagcca ctcaggcact 840
gggagatata agatggctcc agaggccctg gtgccctgcc ccgtggagct cgcaaccagc 900
aggcactctt ctatgtcatg cacagtcctt cccccacact tttgctcgta ccaactactc 960
ctcttgccca gaattctctt cctttttccc tctgcttatt t 1001
<210> 49
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 49
aaatataatt aacactactg aactgtaaag tactgaaatt ataaagaggg tatattttat 60
attgtgtggg gttttgttta accacaattt aaattttttt ttctaaaggt cttgggttat 120
tgggtattta taaggttgaa aaaaaaatgt catcgatgta ttcaagggaa gaatggctac 180
aggttcagcc aactctcaaa tgtgcaaagg ttaatttcta acctctattc ttcccaaggc 240
ttggtaagca ttaactgttt gccagacctt ggaactttcc agcgtcagtt tctcattttc 300
cttcctactt tgtctttcta ggagcccctt tcctggacac actcgtgtct ttcccaggga 360
atgggaagaa acaaaaggat gatgacatga cacctaataa gtctggatct ggaagtaagt 420
ttgatctacg gttcattagg ctggagcaga aaaaaaagaa agggtccggt atgttcgcct 480
gtgtgccagg tatggtgtta ygccactcat gtgccttata ttccctacaa cccctcaccc 540
caatttatca cttcaaaaat gataaaagct gagacttgga gaaactagta actaaccaaa 600
agtcacccaa gaaggaggtg gcaagctaag atcaagcccc actttggtgg gagctaagag 660
tagcccttgg tagagtcatg gggttggcta attcttgcct ttggaacctg tttctatctc 720
cattcagttc ctttctttcc tgtcagttgg actttaaact ctaagatcag gaaatttccc 780
tttatctatc aaatcatacc ctattgagtg agtgcctgct tagcctaatg tcctgcaaat 840
ggacaggact cctctcttct atgactcccc agaaatatta caaaggcctg taggaaatag 900
ctcgggacag accagaggaa atagcatgga ggattcacag tataacttat accttcaaag 960
gtgaccacca gcctgcatcc cattaaaaac aaaaacaaaa a 1001
<210> 50
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 50
ccatttacat taagaaaaat ccccttcaaa agcaacttaa aagttttggt gctgaaaggg 60
ttaacttcag ttatctggaa agcccaggcc ctgggtccgg gaaattcggt ggcagttaca 120
gggttactgg gaggtatcac aggccttgct aacactcagc ttatatgagt ttcatcaaaa 180
acttccaaga tgtgtttcta ggagaaaaag aatgtgtcat ctcactttct cctcacagct 240
gccacgccag ggcatggaga tggggcacag ccctgcctgc tggggcagtg ggtagaggaa 300
gatgctgcac ttagtggaaa atgcaaatga attccactag ggctccaacc tttgactctg 360
aaaagggaag tagaatcatg gcccaacaac ttaaaataaa gaagtgggtg gcttataata 420
actctgaggc ttccaggaaa aagccattct gagtgtaagt aacaaagaag tcaaagaaaa 480
cagccatgcc atctgatgtg hctgcctgga aaacaaggag aaactagtta ccacggaaac 540
aagagagatg gcctctttta cacacaaccc tcggaagctt ctgcagtcag aaagcccagc 600
gtgcaaatcc ttccctggac catgaacaca ggaatgaccc aatgtccttc cacaccacca 660
ggatttagat aatgatcggt caaactcaac tgatccattc tctaattgca gtcagaatgg 720
tctttctaat gacaaccttg atgatcatga tagcaccatt tactgactgc caactgtgag 780
gcgggcactt gacatgtatt atctcagcat tttaaaaatg aacttagagg gtcttgactt 840
ttagtgaaat ggaatagaaa atatcggagt gcatcacatt tggagaaaat aaatttattc 900
atgattactg ggttaaaatg cctcatttat ttcatacctc atatggcact caaaactaca 960
tgaaagcacc tgtttggaag cacctgtgtc tgatcttaca a 1001
<210> 51
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 51
tcttgccatt gtttgcttcc tttcaatctg tatgaacctt ccctaggagt ccacatcaga 60
tatagcaagg ccatgggagc tatttttaac ttcgggaata ctgtatcaaa actaaataaa 120
ccacagccgg gctcgggggt tcgtgcctta atctcaacac tttgggaggc cagggcaggt 180
ggatcgtttg aggtgaggag ttccagacca gcctggccaa catggcaaaa ccccgtctct 240
actaaacaca aaaattagtt gggcgtggtg gcgggcgcct gtaatcccag ctattgggga 300
ggctgaggcg ggagaaccca gaggcggggg ttgcagtgag tcgagatcgt gccattgcac 360
tccagcctga gcgacagagt gagactctgt ctcaaaaaaa aaaaaaaaaa cttaagtaaa 420
ccacatgcca agtttctttg cagattcttt ggaattctgt caatgtagtg tagtagtgct 480
ggacagacca tgtttaatag yagctgtggc cagcacttta gtgtaataaa ataaaggcaa 540
ataaatttta aatgcagctt catggacaaa ttggtcaaaa catggataaa agtagtgtat 600
tacaaagtgc aaagctccaa ggtcaggtag acgtgggttc tgatcccaac tctgttactt 660
attagttggg taatcttagg taagttactt aaccttttaa gctccatagt taccactttg 720
ataagtggtg acaacaaaac ttaaatacta cataaagttg ttgtaataat tcattcttac 780
tgcctggcac tgttctaagt gctttgcaca tattaacaca tttaatcttc tcagtaactc 840
aagtggattt tattgttaga accattttac agatgagaaa attgaagcac agaaaggtta 900
tataatttgc ccagctcata aatggaagaa aagagttaaa ttcgtatcat tcaattccag 960
cacctgagct catcaccact tattagcact gcgtttccag c 1001
<210> 52
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 52
cataagaaaa aatggtgtcc tataacagaa ccagatgcag agaacattgt tacatagaac 60
atggaacatc ccaaaagtag tcttacacat aaaaagctac ttaggaaaaa agaacaatgg 120
acagaaaatt gagaaagtta gattcttatc ccagtttcca ctgttgtgtg aaaagtgact 180
tgaatctcct cctctcttga cccttggata aataagtaaa taatttgcta cttttactta 240
aagcaattct aatgcagact ggggagtgac tctatgcttt aaagaaaata gtatttttta 300
aatgtacctt aaattatgat gctactagat aaggataatc tcaaccacac aaagaatact 360
gactctgtaa gtgatcagtt attgtgattt taggcatgtt aaatcttgtt tattacctaa 420
agtgtatggt caactgtaaa attaccagta tttttaaaga aagtattaac tgaaggctct 480
accttcataa tatatccaaa rtccagtccc ttctcacttc ctccctctgc taccaccctg 540
ttgtgactca ccaccagctc tctaacaggc ctcctgcttt ctattcttgt cttccaggct 600
gttctcaata cagcagcggg agtggaccta gtaaaataag taagatgatg tcatctctgc 660
tcagaccatt gtagcagggt atctgggagt aaaagctaaa atccttataa gaccctgtgt 720
gataggccca tgattcattt cctgacctct tttctgctgc actctttgtc cttctaccca 780
ttcattccct ctttgctatc ccttgaacat gtcaggcatg ctcctgcctt ggtgagtggt 840
ggctttagct cttctgtttg taacactctt gccacagcta accccttaac tcttccactt 900
tggctcaaat ctcaccttct cataggtccc ctcaccaccg tatttatacc acagcgtggt 960
tccacctttc ttgccgaaca atcccaatct ctccacctgg c 1001
<210> 53
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 53
ccaatgtggt acaaagcagc cattgacaat acagtttaaa tgtgatcgca tcaaactaga 60
aaatgatatg caaggaagag atttttcagc ctttgttttg gatttcagat gcctaatcat 120
tatgatctag actgccctac agccccaatt ccatgcacat tcagtacttt tggttgccat 180
gaaaaggtaa ggtttttttt tcttttaatt cttgaatata agtaaaaaaa aatatttaca 240
tcatgtagtg gagaataaca acaagaatgt agatgtagtt gtaaagcagt gtaataagtg 300
atataataga gttattcatg gatgctgtga gcagaagcaa aggcatactt agcaatgcct 360
aaagcattca gacagacttg acaaaacatg atgctttggg ctgaatcttg acaggtgaaa 420
tagttttcca agaagacaaa ggagagaaga ccagtgagaa agagtgagca tggtgatttg 480
aggaactaca agtagtttgt rttgtgctag ttcaacccaa tagcaatgta gatgatttga 540
ggtggaggtg ggggtactag tacctgagct gttggaatac ctaagtgaag acagcttgaa 600
ttatggcgat gaccgtcaag atagacctag gagccagtac atatttagga gagaagatct 660
actgcctgtg tgactaaata aatgtgatga gtgaaggaga gggaggcgtc tagaatgact 720
cttggtttct ggcctttgtc actgggtaga tggaagggcc attcggcaaa aaagagtgaa 780
cacaggaaga actgactgga ggtagagttt aaaaaaaaaa tctgttttaa tgtattgaat 840
tacagataat gacttcaccc agctagggaa caggtgggat gactgacatg cattatgtgc 900
tgtcttaagc cccaaagaga aattaggact cagagtattg atttgggaaa gtgatttgtg 960
gtaataatgg aagttgtgat tgagatcata tggcgtatgt a 1001
<210> 54
<211> 601
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (301)..(301)
<223> n is a, c, g, or t
<400> 54
tggaatcaca gctctgcctt cgagctgtgt gactttgggg cagttagttg gcctctctga 60
gcctgtaaag cgggggtatt agagtctagt catgagatat cttataggta agtaaactag 120
catagtgctg gataatgttg taacaattca tgtaataaca attactatgt gattttaaga 180
tgtcagctcc cttttctgga ttggaggatg gaaaggcata tttgcatatt ttcagttgag 240
ttctcccacc cagtcctaca tttactatag taaaaccttg tagatcaaat gtaagtaatg 300
nctctctttc ctccccacac ctaatgctgc acctcccatt cagagtctta ctagtgaaga 360
ctagtaagtt tagattactt attagtaaga ccagagagtt aggatcaata cgtgcaccct 420
tgtgagatgg aatatatttc tgccctgaga atctctgttg gtcttagcct ggaattaaga 480
tcctgtagca ccacacctct gctctctggg ctttaatagc tcctggctgc aagtttttta 540
gcatgtgcag cttgacattt tatgtggaac tgtcttctgg cctctcctac aagtaatgac 600
g 601
<210> 55
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 55
atggatggaa ttctctttct aggccatttt tattcgatgc cagattacat agtaaggtca 60
tttcagtttg agatgcactc actcaactat tagcactact gcaaataaca gttatgagta 120
tgatcactaa gtgttcattt tacactgaaa agaaatagaa tagtcagttt ccaaaccaaa 180
tagctatact ccctgaacaa cagtggaaag tcattcttct tgaagtttga cccagaatca 240
agtgcagact cagactccta ggcctacagc cagtggcaac ttaacacatt atatggttga 300
ccttcaggga aaaagggaaa ccactgctct taccactggt gccagaaaaa agccaactaa 360
tctttaaggc acaaaataaa ctattcttaa ggcagaaaaa gaaactgtga ggaaacaagt 420
tagaatggag gcatatagag aaaaatacag aaaatacatt accaagtaag gactagtttt 480
tccatggttc tcagtgtttt yatttttggg aatataatta atcagcattt tctttttggg 540
ttttaactcc tactacctgg tagaaatgca aagatgtaca agaaagatgc atttttaaaa 600
aggcttggag acttaaaggc aattatcttt gctaatttta ctttgagcca gtgacattaa 660
taagttcata tagaaaagta aatagttgct gggcatggcg gctcatgcct gtaatcccag 720
cactttggga ggctgaggcg ggcagatcac ttgagcccag gagttcaaga ccagcctggg 780
caacatggca aaaccctgcc tctacaaaaa atacaaacat tagctgggca tggtggcatg 840
tgcctatagt cccagctact cggggggctg aggcgggagg actgttgaac ccaggaggcg 900
gaggctgcag tgagctgaga tcgtaccact gcactccagc ctgggtcaca gcgagacctt 960
gtctcagaaa aaaaaaaaaa agtaaatagt gatgggatac c 1001
<210> 56
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 56
atttacaact ccatagtcca caaaattaag tctttaatat ggcaccttcc aagatcctcc 60
atagtaacaa cgataatgca aatacaataa catcaacaga aaacgtttcc tgaatgcatt 120
atctcattca atcctcaaaa caaccctttg aggtagtaat tattatcatc ccattttaga 180
gaaaaagaaa ttgaggtaca catcctcaac cacacttggc ctcttgtcaa tccatcctta 240
tttcagccat tcccaactac ttgtatcact gtgcccctct gcagacttct gtgctgtgga 300
catccttagc ctgcactgcc ctgccttagg ccgcccctgc tgtttgttgg gtgaacaatg 360
gctaatcttt ttagacccag ttcaggaaag gccaaaagct agaggaatgg tatttcagca 420
catatgatca gatttggaag tgatcttaaa gagacatcta gtttcacaat ctatagacta 480
tggattccaa ctcccattag ygggtcaaag ccagggtttt tataaaattg aaataaaata 540
gaataaaaaa tatcagagag cagggagtga aactatgtat tgtttcaagg gcaggcattg 600
ttttgtgaag gttgtgtatg ccaggtccca aagtaaaatg tgttttttac tgtgggtaga 660
ggtccaacca ccaagccact ctccacgcca gaagccagaa tgatctttct aaatctgatt 720
acgtcagact cttactttga aattttctgt gttttcctat ttccattaag attaaagaca 780
aaacaaaaca cctcacaatg cctacccagg gccctgctgg tctcccgttc ttctgaggtc 840
atcccaagcc tttgaaggtg ctgttcctgc ctgtacactc tacccttgcc ctttacacct 900
tctaagtccc attaatcctt caagattcta ctcaaatatc actttcccca agaaacctct 960
gcctaagttt cttgatctag tctaggttgc tagactagga c 1001
<210> 57
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 57
ctggaggaag tgggtgaatg ggtcagatct catttggtgg cctcttgggg aagaagggtg 60
atatactcct gttttctctc tgaaatattc ttcctgaggc ttgtggtggg atccagggtt 120
aaaactgagt gaagagaaaa tattgccttg agaaacaata atgactctgg caacccacct 180
attctttagt agcccatctc aattgacctt cttttaattg ttcatattgg acagactgga 240
gactgcagtg tggggagagt catcctctta cttatcttgg cctttggctt cccactgcag 300
acagcccttg caggtccatc caggttgggg aagatggttt taaaaggttc attagttaag 360
aaaggccctg gggcctggaa ataaagggtt tgaggaggag agtagagggt ggggtcttcc 420
tccccggacc tcacgattgg gaatgaggat tttttttagc tacacgggtc tgactagagc 480
tgtaaacgtt actcagattg ytcactatgt ctcttcccac gagcccctcc ctgtcaccac 540
ccccctgctg tcaaaccata tcttcgtgga ccagccatgc gggacatccc tcttaatggg 600
agcataagag tgttgtctca gacccttatt ttgttagttt atgtttccat gaagctctta 660
atgtttatta aataaacaga caatgagttt gtgtgacatg cccacagctt ctgtgtatgt 720
gacacatgcc tagcctgtgt tctgggagtg tatgtcactt tggcctttgg ctggggaact 780
ggtgatggtg ggaggccact caattactct ctctgcaact gtataactat taatacttct 840
tcagaactgt gggaaatggt tctactcatc agctttatgg aatgtgggtt agggagaggg 900
gacagaatct cttcaaggtc tggatgctaa acgtacccct tccttattcc ctcccaatgc 960
agaaaaaggt ctgggatgtt ctgacagggc catctctgcc t 1001
<210> 58
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 58
attttcattt gtgttttttt aaatttctag tgaggtcatc taattcacct ttaaatattt 60
tatcttattc ttttgttttc aaatgctcta cctagccttt caagagtatt cttcacaacc 120
aaagcagtcc taagcctaag cagaaaggag aaataaagtt gatgggggaa aaatgtatat 180
atttttttct aaaataaggc ttaggagtaa tttaaaacaa aatgctgatt tggtattcaa 240
ttgtcctctt taagggctct taatatgctg aatataatta aaacaagcaa ttagcaattc 300
actcaaattt atctattttt caagttaaat aacattctaa taagctaaca agcacaaaac 360
agatcagcag ttatcataag gtcaggggtc ataaatatgt aaatgcctac aaatgccagg 420
cattaaacat aaatgagtga actgaaagca cattcactgt ctcaaaggga gagccacaac 480
tcagttccat cttattactg ycaagtgtaa attcaagttc aattttgccc tatttttcaa 540
acttcaaaag gcataaattc agattttaat gtaaaatctc ctgattttta aatgctgaag 600
aaaaaaatcc aaaaaacaat ggtgggccct tctggataag tttgttctct gccctagata 660
aattaataga ataagaacaa aatctaattt agttattact gatgacagta agtcaagaga 720
aatttgccac atcacaaaaa tacacatttg tatttctgaa aataaaacta ctgatataaa 780
tcatgacctt tatgtgaggg tctgaaaaga tcaatatgga atcaacagtc catttctgaa 840
gatcattcac agatacactc tgtcctcctt gagttcaacc tttagctggg gttagacaca 900
cctctagaga agtacataaa actttgcaag gaccaaaatg gaatacatgg ttttaagaaa 960
atcaacttct aaagcttcaa ctttatcact ctttcctata a 1001
<210> 59
<211> 501
<212> DNA
<213> Homo sapiens
<400> 59
taggggaagc tttattctga gatctgcaca aaagtgggtt atcctggcag cacagtgtac 60
ctcgtagttg ttctctgatg tgtaaaactt ggtgtaacac atctgagtgt gtgtgttggt 120
gttttattcc agtagttaaa atagacataa gacaaattca tataaaatgt ttgtagactg 180
caatgtcttc tgaagaatgc tgtcagaaaa tcattattct aggtccccag gtttacatcc 240
ctctgtgaga ygctcttgta ccagttgttg ggtaatttga acagttgcct ttgtggtacc 300
attaggagtc tcaactttta aggatcactt acagttctgt gcataggtga ttttcaaagc 360
acctgggtga agttacatgg ctctagaaaa ttgagcttta gaaaacagca ataacactga 420
aacaatcttt gggagtgagt tatcagagaa cgtgcattgt tgccaaggat gctggcataa 480
attctgggaa cctcaaaata a 501
<210> 60
<211> 807
<212> DNA
<213> Homo sapiens
<400> 60
aagtgtatag actgcacctc cccactgtct cttcctccta ctctggccag gtgaagtatt 60
tgctctccct ttgccctcca ccatgatcat aagtttcctg aggcctcccc aaaagctgat 120
gtcaccatac ctgtacggaa tcatgggcct atggaaccgt gagccagtta gcctcttttc 180
tttataaatt acccagtctc aggtatttcc tcatagcagt gtgagaacaa actagtaaac 240
agtgtaaatg ctttgtaaat agttgttagt taaactgtac tgttttggga ataatgacaa 300
agaaaagagt ctgtatgtat tcagtacaga ggcagccatc cattttttaa aaatatcttt 360
aatccacaga tgcagaaccc atgagtgtag agggctggac tgtatacatg aatacatatt 420
gacatcttta tttctatatc tatatatcca aatatatttt gaaaatcatg agtttacact 480
gatacctcta gtttgaatcc rataacacag gttcattcta gtttactccc ttttcatatt 540
tatacctttc ttctctgaca gtgagaaatc aggcttcctt tatcctcagt atattcactt 600
actggctaat ttcccctccc cattgcctat aaactactca tctcccattg gtgctgccac 660
cacaatccct caatctcata tgcatatggg tgacctcctc actccacttg gtctctgaca 720
tcctgtgtga gctccctgtc actgccctcc cccccatatg ggtgctcttc tcacccctct 780
ttggcttaaa aacccaattc tgggttg 807
<210> 61
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 61
ttatgcaaac cttgagtttt atgcaaataa gaattcagtt ccaagcacaa ataattaaaa 60
gcagggtttt tacagtcacg attgccccct ggacatttga aattcaagtg agacatgggg 120
caattcttca ttctgcagaa atttccatgc aatgccagaa acctaatatc cctagcccta 180
tgtacaaaat gctagttgtg ccccctttat cactgtgata actaataggg ccttctgcat 240
gagtctaaac actctgtaga ggcgggtttg ctatggtcct gctggtaggg cagggactat 300
gctctaatcc cttgaataac ttctcacttg gtggagtgtt gtgtacttgg ggggattcaa 360
tgagtagttg tgaattgatg gagttacagt agcactgaac agagatgaaa ggcagcaaaa 420
tcagttagta tagtacagtc ttccctaagt atcctctggg gattggttcc agaacctccg 480
cggataccag atacccaaat yctcggatgt tcaagtccca caattggccc tgaagaaccc 540
acagataggg ggtgccaagt gtatttcaaa accagtttga tacggaattt gaaaatgtga 600
actgtggtaa gcagaataaa gatgtccacg tcttaggctg ggtgcagtgg ctcacacttg 660
taatcccagc actgtgggag gccgaggcag gtgcatcact tgaggtcaga gtttgaggcc 720
agcctggcca gcatagtgaa accctgtgtc tactaaaaat acaaaaaata aaataaaata 780
aaattagctg ggtgtggtgg tgcatgcctg tagttccagc tcttcaagag gctcaggcag 840
gagaatcgct tgaactcagg aggcagagtt tgcagtgagc caagattgcg tcacagtact 900
ctagttaggt gactgagcaa gattctatct caaaaaaaga aaggaaaaaa aagatatcca 960
catcctaata tccagaactg gtgactattt tatgttacat g 1001
<210> 62
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 62
tctcattgca ttttttttaa atttttaatt attatgacta cataatagtt atatatattc 60
ctcatatctc aatttaatta ccacaatcac tgtttttaca aggtcccagg caagaagagg 120
tgaggcaaat ggaggctctg aggaaagtgg ctccaaagcc tacatgatgg aagataactc 180
tggaagagaa agagatgacg ttcctaagct tgtatagcaa aacttgagag aaggtaacga 240
agatgtgaca tctgaactca gagaaatata acttctatag aaaagaaaca aggccttgca 300
gctctataag gaacagtaaa taaatcaagt atgcacacaa gaagtaaaaa aatatatcca 360
agtagaaagg aagcttttca tgaaatgtcc acagagctca tgctctgtag tgactgtaat 420
gcaagattca aggctctatc tagaaaactc ctagccagtc ttgacggacc aagccctaca 480
ctgagcatgt acagagtctt yctgttccat gcagtacttg ctaacaaaac taatttaaat 540
gccttaccat gactcgatct cctttaaagt acctcattag tccttgatat ccctttgctg 600
tatctctggc ttgccttgcc actgctctgt gagtccccac aactcctcct ccacacatac 660
tcttccccca agagcttggc acagaataaa gatccatttt agatctggat ttaaatagtt 720
ttctttacta gctcatttcc ttatctacta atgagggaaa taccacctac gtcagagtgg 780
gaattaaatg aaataataaa cctaaagacc ccagctcaat ggttcaaaca taaataatgc 840
caaatattca ttcctctccc catgcccata tcctctcacc aagccccaat gttctatagc 900
ttatgaccca aaacgctaaa agtagaacat tctaatattg agcatattaa cagaagcttg 960
aagagatatg caagttataa atctgttttt gttcttcctc a 1001
<210> 63
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 63
ctacattaga aacaggtttt ggaggagtag tgggaacatt gggtgatttc tagtggggtt 60
agagaaagca gtacctggtt ctttggccac atctaccaaa gcaaagacct agacttgtag 120
aggagagtat tgtttgcttg tttgaggatt gtatttccca ggtttgttca tttgcatgag 180
tggctgaata atgtaacaga gacttcagaa gtaaggaaaa tggttgtcac caaaatatct 240
tgttttacct ttatttggac taaatggaaa acacatgttt aatagctaag gctattgagt 300
gcttatcatt tgccaggaac tgtttctgag cctttcacat ataacacctc attttatcca 360
ccctctaccc ctaacaaatg gtgtggtttg agttggcctt ggtgaggtat gaaaaggaaa 420
caaagcagtg acctcttcct gcaggctggt cagatgtttg ggataacatt ccttagcatt 480
cttggtggaa gtggtgattt ygttgaaagc tgcttcccag ttgctctgga gtgcaggtgg 540
gaggggtgga ctttggcttt tccaaaggat cccaggaatg ggaaggacct taaagatcta 600
gaccaggggt atccaatctt ttggcttccc tgggccacat tgtaagaaga agaattatct 660
tgggctacac gtaaaatacg ctaacactaa tgatagctaa tgatcttaaa aaattgccaa 720
aaaaatctca taatgtttaa gaaagtgtat gaatttttgt tgggctgcat ttaaagccat 780
cctggactgc atgtggccca tgggccatga attggacaag ctttatctag actgttctga 840
actactcatc tgcctccccc agcccccacc cccaccccac acatccagaa ttctccaccc 900
attggttgtc tggcctctgc ctgaatagct gagtacctgt cttttccaaa actacccctt 960
gaggggagac ttacagcacc ctgtagcata gtatatgata t 1001
<210> 64
<211> 1402
<212> DNA
<213> Homo sapiens
<400> 64
aacttgatcc ttaacagaat ctcatgagag ctataagtct tattattatc ccctttattg 60
atgagaaaac tgaggcccaa ggaggttcag taacttgacc aaggttaaac ttccactagt 120
atgtggcaca tgtgtgattc taatcaaggg aggctggctg caaagcctct gcttctgtta 180
ttgctagaat ctaataagtt atttactaag tatgtaagga tacagtctca tttaattctc 240
acagtaacat tgtagatgag tgattagaaa atagctaaaa gacagacact tctcaaaaga 300
agacatttat gcagccaaaa aacacatgaa aaaatgctca ccatcactgg ccatcagaga 360
aatgcaaatc aaaaccacaa tgagatacca tctcacacca gttagaatgg caatcattaa 420
aaagtcagga aacaacaggt gctggagagg atgtggagaa ataggagcac ttttacactg 480
ttggtgggac tgtaaactag ttcaaccact gtggaagtca gtgtggtgat tcctcaggga 540
tctagaacta gaaataccat ttgacccagc catcgcatta ctgggtatat acccaaagga 600
ctataaatca tgctgctata aagacaaatg cacacgtatg tttattgcgg cactattcac 660
aatagcaaag acttggaacc aacccaaatg tccaacaatg atagactgga ttaagaaaat 720
gtggcacata tacaccatgg aatactacgc agccataaaa gtgagttcat gtcctttgta 780
gggacatgga tgaaattgga aatcatcatt ctcagtaaac tatcacaagg acaaaaaacc 840
aaacaccgca tgttctcact cataggtggg aattgaacaa tgagaacaga tggacacagg 900
aaggggaaca tcacactctg gggactgttg tggggtgggg ggaggggggg agggatagca 960
ttaggagata tacctaatgt aaatgacgag ttaatgggtg cagcacacca acatggcaca 1020
tgtatacata tgtaactaac ctgcacattg tgcacatgta ccctaaaact taaagtataa 1080
taataataaa ataaaataat aaaaaagaaa atagctaaaa gatgtgaagt tggctagtct 1140
aaagattcaa aagtaatgaa tgggagaaag agaaattaga ctcaccatgt cctacttatt 1200
thgacttttt actgagctga actgcttccc ctacctgcat atccaggaaa atgggtaagg 1260
tctggtagat gctttcagcc ttatcgtgct atgatgtttg ggccgcagtg ttatttgctc 1320
attagtcctt tcttgtttct taaaatttaa catttagcca ctgttttgta aattctgact 1380
taggtgccaa gttatggcgc ta 1402
<210> 65
<211> 2022
<212> DNA
<213> Homo sapiens
<400> 65
gctgggttga agtgaggctg gaggtggagg caggggccag tgtagtggtg cagagccact 60
gaagagctta agcagagaag ggacataata atgtttgggt tcttaaaaga tcacgttcag 120
atcctatatg agcaggtgat ttgagggggc aggagtggat ctgttagaag gctattgcaa 180
gtggtccagg agcaagaggg tggtggcttg gaatagtatc atagtagtag agatggagag 240
aagtgaatgg atgtaagagg tatttaggga ggtagactgc attgaacttg gagaatgact 300
aagataggaa gagaagggga caatgcttgg atttctggct ttggaaacca tatggatgac 360
catccttgtt cctgagccag acctattgtg ggaagggcag attttgaaag aaagatcatg 420
gtttagttgt tgacatgctg aatttaaggg ttggagtaca tacaagtgaa gttagatcaa 480
tagatctgat gatcggaggg gagatctggg ctgtgcataa agttgggagt catctgggat 540
ggactgaagt catgagagag aatgaatggt agcagggaat ggggattgga catgtgacta 600
ggaataacca cagaggccag ttgaaaatgt atggaaacga gaacatcaag catgaagggc 660
catgcccagt gctaaggaga aatctggtta ggaagtgcat ggatttagca gcygtgaggt 720
tggatttagc aatcaagatt ggcacctcaa gcaggagaaa tttaagtgga gttgtgggga 780
cagaagccaa ttttgaacac tagatgagtg aattggaggc aggaatatga agacactgag 840
tatgggtacc ttttttgaga agttgggctc aaagggtaga gacagttaga ggggacctgc 900
aagaggtgtg taggatccag gcatatagct ctaggtctaa acatctctat gtttggatat 960
ttagagatgg aagagaaagg atatttagtt gcttaaggtt cctgcaaaga caggtgggat 1020
gtaacccaga gcccacacga agggacgggc atttatctcc agcacttcag aaggagagga 1080
agaggagggg gtgggtacag ctgcagatgc aggcaggtgt ggaggtttgg agtggaatgg 1140
taagtgatac cattctgata atttctgttt tctctgtgaa gtaggaggga aagtcatctt 1200
cccagatgaa gggaacggaa tcaggttgct gggtaagatc agttctccag ctgtgcttgg 1260
cagctaccac tgcaagcatg gaataggcgg ctaggtaagt tcagccaaga ttgaagtttt 1320
actctgtggg agtaataaaa ggacaaggaa cacgaaggct aaggacatta acacatggag 1380
gaatgatttc agtggaggtt cagttggatg aagataggtt agtgctgatg gagaatgacc 1440
tggcagtgtc agggggcaat aaacagggta gtggtagtac ctgaataagg gaactagcta 1500
tgagtgcttc tccaactgta atgctaatgt gaatcacctg gggattttag taaaaacgca 1560
gattctgatt cagcaggtct gggctgaggc ctcagattct gcatttctaa caagttcctg 1620
tcacgccagc ctctctggcc cgtggatcac actgtgaggg ccaggtgtgg tggtgcatga 1680
ctataatcca aacactttgt gaggcccagg tgggaggatc acttgagctg aggagtttga 1740
gaccagcctg ggcaacatag acgtcatctc tacaaaaagt ttaaaaatta cctgggtgtg 1800
gtggcttgtg cctgtagtag ctacttgaaa agctgaggca ggaggatcac ctgagcctgg 1860
gaggtcaagg ctgcagtgag ccgagattgc accactgcac tccagcccgg gtgacagtaa 1920
aagcctgtct cttaaaataa aaaaaaaaaa aaaaaaaaaa gatttcgggc agagagtggg 1980
atgcctgaat tagaaatcgt ttgacatggt ataatctcaa gc 2022
<210> 66
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 66
gtggcttctc tttggaaaca gttcactggt tttctcaagg gaccaatggg ctatgaagac 60
cagggactgt ccaagctggc cactcgggaa atgaaaaaaa atatgtgacg gaacatggga 120
aagaaccaca agtggaagaa gtttggacac acaggattct acctttttgc tcattctacc 180
caaaccatct gcacattgat aaattattag gatgagctgt gcatcctact ttacaatata 240
catgtccatg ggggagaggt caatagaaac agttaccacg acagttggtg gagtcagaac 300
atctggcggc tacacagaca caccagctgc gtgacttggc aaactcagta tctctgtgcc 360
tcatattcct catccgtaaa atggagcagt gacgaggata ttgagagttc atcaaaaagc 420
acttactata gtgccaagga cacagctaag tgctcaaaga ttagccatga tgatgatctg 480
actatctatt tttatccctg yttgactaat ttttgtggga gaacaagggg aagaggtgaa 540
gaattgatgt aactttcata tattacctat cctacttttg tatatgtttg aaaattctta 600
taatggtaag ttaaattaaa aaaaaaaaac ctaatgtgtg tgtgtgtgtg gtgttttttt 660
gtgtgttttt ttgtttgttt ggttggtttt tttgagatag ggtgacgggg tcttgtcact 720
caggctggag tgcagtggtg tggtcacagt gtgatcacag cctaaattcc taggctcaag 780
ttatcctccc acctcagcct cccaagtagc agggactaca ggtgtgcact accacacctg 840
gccttatttt gtgcaggaga gaataaggtg aagaccaatc catttctaat atttttaagt 900
ttcttctatc attagatttt ctaaactaat agcaaacttt tttgtaaagg gcccaagagt 960
aaatatttta cactttgcag accatatggc cctgttgcaa g 1001
<210> 67
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 67
tcgtcttgaa attcttaatc atatttgaac aatgtcccta cagattatgt agccagtctt 60
gctactaccg agctgcactt gacctccccg cactcatcct ggccatactt catccctgtc 120
cctctccttt ctactgcctg gtgctttgtc ccatttcctt gcccccaagg ccttaggagg 180
gtgtaaaaaa aaaaaaagat aaattcctca gggaaaagat gtgatttggc tcacagcata 240
tggaatattc aaagatagac atcatctgtt gcccacattt ttatgagact gacatgctgc 300
ctgtagcatt gagaaggcac tggttgccta cacttttaga agtcatttat taatggcttc 360
ctagggcatg ccaactctaa aatcaagcca caaaaatgat accaggtaaa aattgatcct 420
gtgaataact gtgacggtgg catttgggtg aaaggtcttg aaatgggctg tgtcttttcc 480
ctcaactttc ctcacccgct yttatcacac tctcccagcc agtgtcagat tacttctctt 540
ctcatctgtc tcataaatag ttctggcttg agttatcccc taccgtgatg acatatgatt 600
attcaaagaa agattttata gaaaatgcat tgtttctatt tggagttggg agactaggga 660
aaggtataaa gcacgccaca ggggcacagc cttgattgac tttctgtgct cagcttagcc 720
gttcaagccc ggggttgtgt ctgggtaaag ctgtttgact ttgggtaagt cctttaacaa 780
cctgaggtcc cagtgttctt aactttctac agttttgttc taatccagca ttcttgaact 840
agcacataag cataacttgc taaataagca ccacttgcta aatacaggct tagtgacaag 900
gaagttattt ggaaaatgaa aagagggcaa ttctcccatc aggacttgag aagccttgga 960
gttttctttc tttattgaaa agactcatga ggcctgtcca a 1001
<210> 68
<211> 1958
<212> DNA
<213> Homo sapiens
<400> 68
accccaaggt ggaagcttta catgactgag aaagcccatc cactcattgt catagaatca 60
actattaatt caacaaatac ttatggagcc tttgccatgc ctatgagcct tgtgctagaa 120
gccagggata agtaaaataa attctgcacc tgcctcctgc aacttagtcc aatttccagg 180
tctcccttag atttttctct gttttaattt ttattttgaa aatggagaca gggtctcact 240
atgttgccca ggctggtcat gaactcctgg gctcaagtga tcctcccgcc taggcctctt 300
aaagtgctga gattacaggc atgagccatc acacctagcc tctctcttaa aacaacttta 360
ttaaagatgt aattcaggct gggtgtggtg gctcacatct gtaatcccag cacttgaaaa 420
ttacttgaag ttgggaggtg gaggttgcaa tgagctcaga tcatgccact gcactccagc 480
ttgggtaaca gagcaagagt ccctctcaaa aaaaaaaaaa aaaaaaaaag taattcacat 540
accatacatt tcacctgttt aaagtgtaca attcagtggc tattagtata ttcacagagt 600
tgtgcatcta ttaccagaat caattttgag cctttttttt tttttaaccc caaaaagaaa 660
cctcttccct ttaacactta tccccagtcc acctatcctt ctcagccctt ggcaacagct 720
agtctacttt ctgtctctat ggaccggcct agtctagata ttttatataa atggaattat 780
ataatatgtg gccttcatgt ctggcttatg tcatttagca taatattttc aaagttcttc 840
catgttgtag catgggttag aacttcattc ttcttttatt atggttgaat gatattccac 900
tgtatgaata taccacatct tttttttttt tttttttttg gagacagaat cttgctctgt 960
tgcccaggct agaatgcaat ggcacgatct cggctcactg caagctccgt ctcctgggtt 1020
caagggattc tcctgtctca gcttctcgag tagttgggat tacaggtgca cgccaccgca 1080
cccggctaat ttttgtattt ttagtagagg tggggcttca cctccttggc caggctggtc 1140
ttaaactcct gacctcatga tccacccgcc tctgcctccc aaagtgctgg gattacagga 1200
gtgagccacc ccgccgggcc acatcttttt ttaatctatt ccttcactaa tagattgtgg 1260
gttgtttcca ccttctcact atgtgagtaa tgctcttatg agcgtgcata caagtttttg 1320
tgtgggcata tgtgctcaag tctctgatcc cctagatgtc ttgcctatcc tacagatcca 1380
ggcctaccac aaaaaagtgt agaaggatca tataccatga gaacataaag gagggacatg 1440
tagacttaat tagggagtca gggaaggctg cccctgaggc caccatatcc aagctgcggc 1500
ttgagagatv ggttgaatag aaaagttttt caaactgcag ctgatcaccc attagtaggt 1560
tgtgaattca gtttagtgaa tcatggccag cattttttag gaggtgaact aaaatagaat 1620
agtagatgtt agaggacatt ccatgtggta agggtaagta ttgttgcatg aaatttattt 1680
tcagtagcta tatgagcgca tctagcaaat tgtgacgtaa gaagtattct atattccggg 1740
ttgcaatcag aaaaatatga aagccactgc tctagggatt ttttaaaagg agattattta 1800
ttaatctgga gctttaaata tggttccact agaagattgg agagatacag gagagagaag 1860
aacctagaaa gctgaagatc ctttgaaagc ttaaagttct gtgatttcta cacttttaaa 1920
atgattcatt tattcaacaa atattaaaat atttacca 1958
<210> 69
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 69
tcatatactg caacacaaca cacacacacc tcacttacat agacttttga tttaagctgt 60
gttcagattt ctcttagcac attcaagttt tccttccttc ttcccagaag cacctaaagg 120
ctgtaatgag aaacatattt tttactcctt tgttccctct ctttgtgtaa aggcatccca 180
agaaaatcag tgaaggattt tgtgctctat gtccctaagg ctccatgtcc cagttatttt 240
tctctctcaa ctggggcttg atttccactt tattcaagtc tacttcttat ttccttcggt 300
gatccgaagt actggcagat ttttctaaga cttcagacat gtggggagta actttcataa 360
ctccaaagaa tacactacca gaaatgtaac catctcagct gttctccgtc tactctgatg 420
ttgcctgtaa gaaataacaa gatgccactc tgttctttaa aagagatata taacattttt 480
cataagatgt ccttcattac wtggtgcaga attcgaactg atcgtttgtg gattaatcat 540
aataatgact tattttgttt atgttaacta aaaggagttt atcattttta tatgatattg 600
actgaatggt cataggaaat tgagatcttt ttcctaaaaa ggtgataaca tttactggag 660
tgttgtttta gtagataact tgatccttaa cagaatctca tgagagctat aagtcttatt 720
attatcccct ttattgatga gaaaactgag gcccaaggag gttcagtaac ttgaccaagg 780
ttaaacttcc actagtatgt ggcacatgtg tgattctaat caagggaggc tggctgcaaa 840
gcctctgctt ctgttattgc tagaatctaa taagttattt actaagtatg taaggataca 900
gtctcattta attctcacag taacattgta gatgagtgat tagaaaatag ctaaaagaca 960
gacacttctc aaaagaagac atttatgcag ccaaaaaaca c 1001
<210> 70
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 70
cattgaattg ccttattaat ctcttgggtc atgcaattca gtgatataac tagggttagc 60
ctgagtgttt caaagcaaga ttaatggaag ctcattcgcc agctgtcggg ttaggagatt 120
attcacaaat gttgccctgt catttgaatc tggtagggtt tgctgatgaa taaatgaacc 180
ccattatact gacagccacc tcactaatcg atcctaacta aaccacctta tcctcttcac 240
cttccaattg tgtagccagc aacttgccag atctcaggga cgttgttggg acatgtggaa 300
ggtctgagac agagggccgg aaggacagac aatgccacca actctattaa tcagtccgca 360
tttctcagac ctggctctca gcctactgaa tttgacaacc aaggatttgc gtgtagtttt 420
tttttttttt cattttcaat taatttccct ttttatgcct tcctaatttc tcttcttttc 480
tgactaagct atatatttac rctgtgaaat tgactgtcat taatcttttt ctgccttgat 540
ttcctcaact aaaaaatggt taaactaata ccagcccttt cattcatggt gatcttggga 600
ggaaaaaaaa aagagataac tgatgtcaga gagtgctttg aacttaaagc aggaagattg 660
ttcaattata ataagactct tctatcttta tttttatgtg acatttagaa tgttagcgtt 720
gaatacgcgt caaggaagaa aatcccattt tgaatgacag tgttagaatg acggcctgta 780
agatattgga attgcatgca aaaaccaaga aaatgtgttt aaaaactgct aagaccaagc 840
cagctactgt ttcttttcaa agaatatatg tagggaatag gagaattagg taactctagg 900
gcataataaa aaagaagaac atgtgctttc tgattttgcc aatctatttt gtacttactt 960
tataattcaa ttttaagagt aaagtgtaat gtctgattca t 1001
<210> 71
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 71
ctttgggatg gttggctgta cttttaacca ctactctgtc ttgtctctgc atgtgtgggc 60
atgaactttg ttaggttctg aggaggagga tggggggttg ggaggagctg catatgttct 120
ctgccccaga agaatcatgg cccaggggaa gaggtagcaa aaggaacaac tattccagta 180
tgacttgatc agtttcttga tggacatgtg tgcaaggcac tatagaagga cagaagagat 240
ttttacttta attaattgaa aattagtaat ttatatttgg tatatacgta atctaataat 300
tcattaagtg gagcaacttt tcaaactatt ctaacaaaat ctaacattat aaaactataa 360
catggagact gcattgctaa atacctttca tctacaaagg aaagttatag ggatttatta 420
tgttttctag atttctagct ctctagtgct caaaaaaatt gaaaattgaa aaattgaaga 480
aaaactgaaa ttgaagtgac mctcatcttt gttgaagaaa aaggaatgtg acaaaattta 540
tttctatgtg cagtcaaaaa gtgtggtttg tgaaatgtgt tgttgttgtt gatcttacag 600
gagaatcatg aaaaaagtct ccatggagcc atctgagcgc ctggctagtc tccaggcgct 660
gtgggacagc cagaccgtgg ctgagcaggg cccctgtggt gagcatgcat tttaaaactg 720
aaatgtgaat agctggatgg atatccccct gccaggaagt taagtctatt cctagtgtgc 780
tactgtaaag gtgcaattag tttcaaggtg taattagcag cgcacagact ttagattggt 840
ggacaaaagt cctatattta agctgtattg catcctgcta tgtacttact atagaacagg 900
gaggagaatc tttgctgttt tcccccctaa aaaggaaaag gataatcagc attgtcaaca 960
tcggccatat ttaagcttta aaattttaat ttaaacatca t 1001
<210> 72
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 72
gatttggttt ctgtctctac tgagttctgg ttgttctttt gattacaaga actactcaat 60
ttcctttaag taaatttatt tattcttaaa attctgttgc ttgaaactaa gaataagccc 120
taataggcac agaggaataa tttaactctt cctgatctgt ttcctcatct gtaaaataaa 180
ggaaaagggc acacatatcc cctgacccct cttaactctc tcatctttag ctagaattgg 240
gttctagtga ttctcaaatg gatgtgttct aaaagaggct ggctggccct gtgttgggga 300
agcagaagtt ttagtaatta attaggttaa tatgaacttt atagttatat tttttctgta 360
ttccctgaat aactgtgact ctattacttg tgaatttatt taaaacataa atatgacagt 420
gatgactaga tgaggtctct tagcacacat gccctatgca gacctgtgag tcccctgctg 480
tctgctcacc caatagttga rggcctgggt aggagttctg ccacatgtga gttcttaaca 540
caaaatcctc atggaccctg tgggcctgga gctggatact tcactcatct tcacccttgg 600
cctcatgcta agaattacca tcctgccacc acttaaagat gcccattcat gttagtgtgt 660
cactgctaaa gtactgtcat taaagaagac ctatcattac tctgacttta aaatacattg 720
ttctaacaga atcactatgg gagattccag acttctgtat cagcgggtgc tttgaaaaga 780
ggatctgata tgtactggcc cctgtgttca cctgtgggcg aacattagac atgtttgttt 840
cttttatgct ttgataacac cttacaactt gcaatagtgt gactttggaa agaatgaagt 900
gattgtgtct ggcatgctgt atgtaaacat tccatttcta cataatgtga aaaggaatga 960
attaggtgaa aataaatgga tttgcacagg tgttagagta c 1001
<210> 73
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 73
taagttttgt ttaacttatt taactaaaaa atgatgctaa tgaatgtgga ggggtgattt 60
ggatagaacc tgttctgtgt ggggccttca tgtaatccct agagaacgtg taaatcaaat 120
tatgcctgga ggaaatttta tttccaattt cagttgcttt actgatatgt taagggaatt 180
aaaaaatatt tagctcggcc tttcagagag ctgttattac tggttgaact atgactgtta 240
ttttaattct cattagataa ctagtatctt ttgagctgtt gttagctagg ctgtgtgcta 300
aaaagtttta tatacatcct cttatttaat cttcacgaca cttataggag gtagatacta 360
cattatgtgt ttttacagcc aagggtgagg tgtaggggat ctgataattc gctccaaatc 420
acacagctag taaatggtgg agctggtcca ggcgtgtctg tcttgagaag cgctgtacca 480
ttcaccttac aattatatct rtaggtattg tctgactcat agaatccatg cagtacatct 540
gtgcagcttc catttctgtc cttagcctca attcctttct gtctttagtt ctctatcttt 600
accttaaaat ctccatgtaa atcatgctaa cctagcacga tccatggtgc acccacttgg 660
cattttcagg gaaaagggat aaggcctata aagaaagtcc acacccagcg cctggttctg 720
cctgtgccca ttctgactgc tttatcttca gtgctttaga tgaatgtgca tcttcctgga 780
tgcttttcct tcctgcatga tttggaagaa ttagaatcag tcttccttcc atgagtttcc 840
cagggaatca gagggacttt ttaagcataa tgatggaatt tttattgtca ccttttgttg 900
taaaatgctc tatagatgag aaatagatta tatccatccc cccaccagct gtgcttcatg 960
gtaatggcca aaaaaatgtt cagaattaag actgggaatt t 1001
<210> 74
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 74
tgtagtctgg actttcttag ggaagtcctt tacctgaaga atgagtaggc atgagccagg 60
tgaaggtaaa gcaagagggg gaagggatag ctcctaaagc agaggtgggg caggagccct 120
cctcttggga gagcaacaga aggccagtgt ggctgggttg aagtgaggct ggaggtggag 180
gcaggggcca gtgtagtggt gcagagccac tgaagagctt aagcagagaa gggacataat 240
aatgtttggg ttcttaaaag atcacgttca gatcctatat gagcaggtga tttgaggggg 300
caggagtgga tctgttagaa ggctattgca agtggtccag gagcaagagg gtggtggctt 360
ggaatagtat catagtagta gagatggaga gaagtgaatg gatgtaagag gtatttaggg 420
aggtagactg cattgaactt ggagaatgac taagatagga agagaagggg acaatgcttg 480
gatttctggc tttggaaacc rtatggatga ccatccttgt tcctgagcca gacctattgt 540
gggaagggca gattttgaaa gaaagatcat ggtttagttg ttgacatgct gaatttaagg 600
gttggagtac atacaagtga agttagatca atagatctga tgatcggagg ggagatctgg 660
gctgtgcata aagttgggag tcatctggga tggactgaag tcatgagaga gaatgaatgg 720
tagcagggaa tggggattgg acatgtgact aggaataacc acagaggcca gttgaaaatg 780
tatggaaacg agaacatcaa gcatgaaggg ccatgcccag tgctaaggag aaatctggtt 840
aggaagtgca tggatttagc agccgtgagg ttggatttag caatcaagat tggcacctca 900
agcaggagaa atttaagtgg agttgtgggg acagaagcca attttgaaca ctagatgagt 960
gaattggagg caggaatatg aagacactga gtatgggtac c 1001
<210> 75
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 75
gaactcctag gctcaagtga tcctcccacc tacagcctcc caaagtgctg ggattataag 60
cataagctac cacacctggc tgagaattct catttttaac tttctacctg gtggccctat 120
gtatggcaga tgcacctgac agcaataatt taacttaagc atactctgta tggcagatgc 180
acctgacagc ataatttcac ttatgatatg agggttgcca tgtggaggtt gtgtggaagg 240
aggtggggtt gggggaagga gtgttaagga aaaatgctat ataaacagca cgctttttta 300
aagtgatggt tgttcttctg accagcccac tgccactgga ctgccctgta agttcccaaa 360
taaattctat gtttcacctg ctggctccat gtctcttctt cagtcttgtg aacctggtgc 420
catccctatt gaagttaata agggtcatat aatccataag gcaggattct cagtcatttg 480
tgggtaatgc tctcctttga raatctatca ccccctaaca tgcatgtaac acaacatttt 540
gcttatagtt tcaggagatc tataggcccc tgaagcccat ttctggccct tctaagagaa 600
cgtgaactcc agattcaaca tttctgttcc aaatgttcct gagcaacaaa attttctagg 660
tctacctcat cccttggaac ctgatccaac tgtgttccca aaactaccag actctctctt 720
ccatgccaca ttcatctgtt tcttgttttt ctatcatgaa attttgtatt ttgctactgc 780
ttttttacca aaattccttt agataatctc acggctttgc cgaaatccaa ttcacaatgc 840
tctgtctaac ccacgaggat ggactataac tacttcctcc caatcctaga caatgtttct 900
gatgtgttcc tttaagctcc gggagctgcc agtgaatgtg tacctaaggc cctagggaaa 960
gaatccctgc tttaaagagc ttaagaaaga ccatgaggga a 1001
<210> 76
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 76
cctccaggtg acaacacggg tggtgagagc cgccgcatga atccacactg cggctgaagg 60
tcaagaattg gcggtagccc atcggtagcc cagagaccca aactgtgtcc gatgtgagtg 120
aaggtcaccc cagatcagtg cgtcagttcc gttttggcgg ccaaatttct gacgatccca 180
tgtaagaaat gccacacctg tcaataggag cgactcacgc gctgggtctc tttctcggat 240
cgggtcgcca ccccagtgcc gggactatgc taaagactag agtctcagac ttggaatttc 300
gaggaaggtg ttccaaaacg ctgcgctccc tccggcgagg gacaagagca ggagcctggc 360
ttgcctgggt ccaaggacag tagctgggag gggtgtggca gccgcttagc ttgaaatctt 420
tcagataccc caccgaaata tcataaagag cacaaagaac ttttacgtag gaacaaaata 480
gtgaatctac aacaccttaa rcgcctgata acttcacaat gcatgcctag gaaaccaaat 540
agcagtcaaa tggagttagt ccccagagaa gaggaaacgc agaggaatct gatagggagc 600
aggcttcaga aatattgagc tgcctctctc ttctagaagg agagaaccaa ccctgagctg 660
aaatttctgc aaatagaact gagattatac cagacaatgt catggctgaa ggagggtagg 720
aaagtttata aagtgcttgt gttgctgggc acagtggctc acacctgtaa ccccagcact 780
ttgggaggct gaggcggatg gatcacctga ggtcaggagt tcgagaccac tctggctaac 840
atagtgaaac cccgtttcta ctaaaaacac aaaaattagc cggccgtggt ggtacgcgcc 900
tgtagtccca ggtattggga gcccgaggca ggggaattgc ttgaacccag gaggtggaga 960
ttgcagtaaa ctgagatcat gccactgcac tccagcttgg g 1001
<210> 77
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 77
aagcctggcc aacatagtga aaccccgtcc ctactaaaag tacaaaaaat tagccgggct 60
ttgtggcggg tgcctgtaat cccagctact caggaggctg aggcaggaga atgtcttgaa 120
cccgggaggt ggaggttgca gtgagatgag attgtgccat tgcactccag cctgggcgac 180
agagcaagac tctgtctcaa aaacaaataa ataaataaca aaaaataaat tcatattgtc 240
ttaaaccacc aaatttgtgg taagcaatag gaagctaata aaaagccact aagatagtac 300
catgaatagg gctaaacagg cagaaagaag tctacagggc ttttttctgg aacaattttt 360
agaggccaga ggagttcatg gagctcactt ttgttgtcat tgagagccct ggaggatatg 420
ttttgaactg tagagagagt caacagaagg aatttagagt cccaccaaca gttgggattt 480
ctgtatttgg agtccagagt rttaaccgtt ataccatggt atctttgtat aacaaaggtt 540
ctagggaaga cttgtatact attgcatctg gtcagttaac ctttaaaatg ggcatagatt 600
caatgtaagg aacactaata gcttctcata gggagaaaaa tgcaggttct cagatgactc 660
aatttgtggt ttgcacatat tcatgcccga gtccagagat agcatagaga gcattcggag 720
tgagctctga agaagaaaaa agtcataggt ggggcctctg acacatgaac ctttactcat 780
cccagcagat gattaactta cagtggtcta actgacttca ggctccagca aagcaaagca 840
aagctttcaa aagaagagct tctaggatac atgagggtga tgggcagtgg acaactttca 900
gtagccagag aaaagagcaa gaagcgggat gttgctccag aaaagaagtg caaatatgtg 960
agactatcta tacatgccca agtgtgcttc tccatttggg t 1001
<210> 78
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 78
atacaaggga atactgcaca gtttgtaaaa ggaaaaagaa gcaattctct ctatactaat 60
atggaaagat ctccaagata cactttacac agaaaaagca agatgcagag ggacgtgtat 120
agaatgctat ttttagttta aacaagagga aaaataagaa tatattttaa tttacttttt 180
tttagttctc aattgggtta gtttacattt ttaaacttca acaagcaatt ttgtaacact 240
tactgtacat caggcacttt ataagtatta attcaattct tctaacctca ggaaataggt 300
attatcatta ccctcatttt acattagtag attaggccac tacaaacaga gaggttatgt 360
aagtagtcca acatcacact gctagtcaca tgggggagcc agcattgaaa cccataccct 420
ctgactccac aggttatgtt cctaagcatc atattaagtg gactaagaag ttaatacatg 480
gagggaggga ggacagggtg ratgagagag ttgcgtgact ttatgtgtat gtagttttga 540
acgatgtaaa tgtgttacct attgaaaaaa tatttagaaa aaatgtgtat gactttgctc 600
aagttacttt ccatgtgaga ggcagacatc tcaagataag taatagtagt agcttgtagt 660
gagggtttac caaagtctta tctatagtcc tctgagactt tagggagaga atccttattt 720
aacctcatga gatagattcc ccacccccga cctgagctga gcagctaaag cttggggtgc 780
tgcaggctgg ggaggctgag cgcaccagcg cccatgacct acagctctcc ccttcgcaga 840
ccccttcttc aggagcgccc agccctggat cgcagccctg gcagggaccc tgcctatctt 900
gctgctgctt ctcgccggag ccagttactt cttgtggaga caacagaagg aaataactgc 960
tctgtccagt gagatagaaa gtgagcaaga gatgaaagaa a 1001
<210> 79
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 79
atgaagagtg aaggaagaaa tgtaaatgag acacgtgcca ggcacacggg gacccagtga 60
ccagactcca agaaagcgca ggacagggct gggcgcggtg gctcacgcct gtaatcccag 120
cactttggga ggccgaggcg ggcggatcac gaggtcagga gatcgagacc atcccggcta 180
aaacggtgaa accccgtctc tactaaaaat acaaaaaatt agccgggcgt agtggcgggc 240
gcctgtagtc ccagctactt gggaggctga ggcaggagaa tggcgtgaac ccgggaggcg 300
gagcttgcag tgagccgaga ttgcgccact gcactccagc ctgggcgaca gagcgagact 360
ccgtctcaaa aaaaaaaaaa aaaaagaaaa agaaaaaaag aaaaaaaaaa agaaagcgca 420
ggacagaaag agcgaggtgc taagacttag agtggaccca gaggctctgg ccctcctgtc 480
tcccaccacg cactccattt ytgtcacatt tcaaacctat cgcttttacg atatatgttc 540
aaaaattgtt taatgaactg taaatggctt ggtaagggcc gcatcgtaaa tggcttggta 600
tgggccacat cgagaacagc tgtcaaatat aagcctaagg ctaaccacgg atctatttta 660
acactgagca gttgtggctg agtgtctgga gcttggcaga aagcaacgtc acaagtctgg 720
ctttttccca cgtagactga accctcgccc tcaaagctac aaacacaaca atttaaccaa 780
ctgagtgatc aactaggaga agaatcaata tgatctcttt caaaagctta aaatatgtca 840
aaatagtatt atctcagaaa gttttttttt cccaaaataa tacaagacat tatcgaattc 900
ttatttaacc cttttctaaa atcacccacc cacctcattg aatttccttt aaaaaatctt 960
catcctggcc gggcgcgatg gctcatgcct gtaatctcag c 1001
<210> 80
<211> 601
<212> DNA
<213> Homo sapiens
<400> 80
actagagata atatgcatag cttaactaaa aattccaact gctaggaaag aaagtgcaca 60
aatgctaagg gaagaatgca gagaaaaagt gctcccacac atccaggctg acatgtcact 120
gatgtctgat gtcacctata cctctcttcc ttgtataaga aggggcagct ccaggcacag 180
tgcatcaaac actgctgtac aatggctctg gctcccttgt ggaccagaaa gaagcagatg 240
tttctggatg ggagttggga aatgatcagc caccttctcc ctgggccctg gaatcttcct 300
yttccacaag tgacagaaga cctcagaatc ttctctttca ctgcctaccc ctgaccagct 360
ctgccctgga cagtcccctt ccaaagccaa aggcagcccc aatccacagt tgtcaggtac 420
actcacctgg ggagtctgtg cagcatgcct ctgggtggct gttctggcag agcagcacca 480
accagggcct gtttatattt ccccaagtcc cagtgctcat gggcaactcc cactggtgtc 540
acaatgtcaa tgtcataatt tctgactttg ccaaaggaaa aggggtcctt ctgtacaatg 600
t 601
<210> 81
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 81
agcattgtgt ccctgtgagc ccctctacgt tattttacct ctgactggaa cacacctcca 60
tcatttttcc ctcacttcct gcaagttgct gtctaaaggt gactgttcca catttttgtt 120
atgatagagg gtccttattg gtaccatgtg agaaattacc ttgatgccct ggtaggctcc 180
aagtatagtc ccatgcaagc tctcccagag gacacagcac aaataggttt gcagactatg 240
cagtgaaatg ctcaaatcac agcttcatta aaaaacatag caagcagcaa ggggaaaaag 300
aagagcaagt taatggttta gtgtgtaagt gaattggaag aaccacacta tctgactcaa 360
gtgtgagcag tttccgtata tctgatctct tttacatcgc tcaatcagcc tgtaggatag 420
acacagagat atatatgcct ggacccaacc aattagttgg ttgaatagcc atggatttta 480
tttttgttcc taaagtagag racttatggt gtctccaatt tgtggctgac tcaaggcctc 540
atgaataatg agtcagtgct tcgatgtctc atatatctgt gaattctgaa tgtgtggctc 600
cttttgtata ttttgtgcat caggaacatt aggtatcttt tgacccttcc atcccttata 660
tctatattta acaacatatg ctctttttac taactactta tgtctactta aaacatctta 720
agcatttttg cctacatttt actaactaaa agcatattta tcttttataa tagaattgct 780
catttacaaa agtaaatatg tgttacaatc catatcattt attggtgtat ccctgacata 840
tagtaggcac tcaatacata tatggaatga gagaattgtg ctttctctct cccttttcgc 900
cttcccctcc tcctgctttt tctcctactc tcacactgtc tctctctctc aaacacacac 960
acacacacac acacacacac acacacacac acattggaca g 1001
<210> 82
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 82
tctcagcctc caggaccatg agccaaataa acttctattc tttataaatt atgtagtctg 60
tggtattctg ttatagcaaa aaaaaaaaga ctaaaacaga aaattggtaa aggctatttt 120
aatgaggtcc tagatggaaa tgaggagcaa ggtattggaa actagagtaa aggccatcct 180
tgtatacagt tgcaaagaac ttgggggatt gtgtctgcgt tctagggcct tataaagtgc 240
agaacttaac agtgacgaac tgggatatct ggtggaagaa atatctatgc agcaaagcat 300
tcagactgct gtgtggctgt ttttaactgc atacaatgag atgtgagagg aaagaaataa 360
agatggaatt tataattaaa agagaatcag ggtagaaata tttggaaaat gtatagcctg 420
gccatataaa taatagaaaa gtatgttcag gagagaaaac taagtgtgtg gctaagtgac 480
tttttactaa ggagataaac rtggacaaaa ggaaggtgct attcattaag acaatgggag 540
acagaccata aagcatttca aagatcttca agtctgcccc tacaatcaca ggcccagaac 600
tctaaaaggg taaaatgatt taggggaaag gcccaaggca ccctccatgg actcagctca 660
gagctgcctc aggtctgctc ctggggttcc agagcagcac tctgtggcca ccctagccat 720
ggctcattag gcccaggtat ggcttgatcc agaaaatgca agctgtagag cttggcagtg 780
tccatgtggt gctgatgcag caggcatgca caatgcaata gctgtgaaga cctggcttcc 840
tccacctaga tttcaaagga tgttgctgac agtctggggg cccaggcaga gaattgtgca 900
gggacacagc cactgcagag agcccctacg acaatgacaa gtggaaatgc ggggtcagag 960
ctgacacaga gtctccacta gggctgccta gtagagcatg g 1001
<210> 83
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 83
gcgggagagc tgggccactg gttaaacatt tggaacgttt gttatgaaaa gataaagcat 60
ttttcatcta gagcttagga atgactttta ggaaaaacct tacaggattc aggtgacatg 120
tttaagtcag aatgtgaact agttatttaa tgtagggctt acaagaatgt tcgctgtgtt 180
tattcatctc gtgttatatg aactagaacc aataaaaaaa aatccagagc caggctcagt 240
ggctcacgcc tgtaatccca gcacttttgg aagctgaggc gggaagatcg ctggagctca 300
tgaattcgag atctgcctgg gcatcatagc ggatacaaaa attagccgac cggggtggtg 360
cacgccttta gtcctagcac ttcacagagg ctgaagtggg acgatccctt gagccgggga 420
ggctgaggct gtagtgagcc gagaccacgc cactgcacgc cagcctgggt gacagcgaga 480
acctgacttg aggaaaaaaa rataatccag tacagaatga cacggtcata tcaaattggc 540
atgtaataga gaccccatct tgaaacttgc tactatattg tcttgtgcgt tgatagcata 600
ttatattaat gccgaacaca ttagtgacgc cgaagtagct ggtgcctaaa tggcttaaac 660
gcggaaaaac cacatacaga tgatggaaca aaaactggcc aatcagatta tagagcgggc 720
tttttaaaat ataagaagct tctttgtagc taggcgtctg acaaaaagct tgacaccaac 780
ttaacaaaaa ccaacggctg gaattcatac tctaataaca gactgcatgg gtaaactacg 840
tggggagtcc aaccaacacc ctggactctt gcttgccttg cgttactcga ttagggttga 900
gggagaactg cccgagattt ttcgaatgca aggaatcttg ctgcctgatc taacatgttg 960
tgcacagcca ttttttagag gtctctgggt ggctctgaaa a 1001
<210> 84
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 84
aagaaggcag tgacaaaggc ccagaagaag gacggcaaga agcgcaagcg cagccgcaag 60
gagagctact ccgtgtacgt gtacaaggtg ctgaagcagg tccaccccga caccggtatc 120
tcgtccaagg ccatgggcat catgaactcc ttcgtcaatg acatcttcga gcgcatcgcc 180
ggcgaggctt cccgcctggc gcattacaac aagcgctcga ccatcacctc cagggagatc 240
cagacggccg tgcgcctgct gctgccaggg gagctggcca agcacgcggt gtcggagggc 300
accaaggccg tcaccaagta caccagttcc aagtgagccc gcccaccgcg gaacgttcgg 360
tcagtctcgg cccacacccc aaaggctctt ttcagagcca ctcagtcttc ccaaagagaa 420
ctggcactca ctgttcttac agcaggtatt tcttacttgc tacaaagacg atttccaaga 480
ttcctttagc cttgttagaa rctaattttg gctcaagcct ctaatcccgg ttcgggaaac 540
cgaagcgggt ggctcacctg aggttagaag ttcgagacga gcctagccaa catggtgaaa 600
cccgtctcta ctaaaagtac aaaaaaatag ctgggcgtgg tggcggacgc ctgtaatccc 660
agctacccgg gaagctgagg caggagaatc gcttgaaccc ggcagatgga ggttgcagtg 720
agccgagatc gggccattgc accccagcct gggcagtaag agcgaaactc tgtctcaaaa 780
aagaaagaaa aagaaaagaa attaattagc actgcagtgt actgcatgtt gcagcaacgc 840
ttgagacaat tttatatctg aagaaggatg aggtttatca tcagacaaac ctagtaaagg 900
gaaaattcag ttcctgttga ccccaaagaa aatataatac ttaagtgtca ctggtaaaat 960
atccacagtg cttccggcgc tctgtcccta aacttcatgt g 1001
<210> 85
<211> 2052
<212> DNA
<213> Homo sapiens
<400> 85
tgaattcagt atatgttgta aagagggtaa ggtagcatag gttaattgaa tacgttaatc 60
taagggtaaa tacaaattaa aaatgagagg cttaattatc tgttgaaaac aaaagacttc 120
cctttccttt cccatcactt tcaaaatgtc tttctctgtc cttttaaaat gtatgtaaat 180
ccttttaatg gctaaatagg ccttataact cagaatattt tctcaatgcc tggagagcca 240
tccctttgaa atgttaatca ttaaaaaaga tagtggtctg tctcccagtt tccagcgaga 300
aaatgggctg aactttagct gtcacctgac ttcgaattgc aaaacctatc caatgtagcc 360
atacataata agcaagattt ctttctgctt ttgcaacctc ttcataaggt ttcctgtgat 420
aagcaactct ccctggttta atgcttattc aataataaaa ttatttcctt tgtcttcttt 480
gggagaagat tttaaaattg tatttcccca acattagtta acaagtatat ttctctactt 540
gagcttctca ctaatcagaa gcctttttct gtatctgatt tcatgagttt tcgcatagca 600
attagtgaca aggatagcaa tgaatggtaa aaggtggcag agcatgccat cccaaaatat 660
gccattttgg aataagaatt attctgagat acaggcaatt ttaaaaagag taggtacaag 720
aaaggcactt tgaccgttcc cttttacccc cttaaaagca ggaattaaaa ttcccmtgtg 780
gaagatgtcc tccctgtacc aaaaggaaaa gaacattttc atcaaggaca ggaagttgaa 840
accaagagaa ttctgtccaa gcagatctta aaataattct tgttttcctt tagccttcct 900
acatagttac atttccacaa tttactccat tcaacctact ataaaagcat ttaggttttg 960
ctacttcttt ggggtctatt attagagctc ccatgtccca tgccacataa aatttatatt 1020
aaatttatat ggttttctcc tcttaatctt atgtcagttt aattatcagg ccagccataa 1080
aaactcttaa gaggacagag gtaaaatttt gcctccccta caaggatatt tgagtttgtc 1140
agactcttta gtttctgaaa ttgacggtaa atttagttct gaaatagtaa acatacacgc 1200
agtataacat tttaaaaaaa tgttatgcta atcagtctgt tttctaacag gataactgac 1260
tatcaagata aacttagttc aaatagagta actctgagtt ctcacattct ttcacattac 1320
aaaacaaatc tggcagcaaa ctttgtcaga ggcgtttaaa ccagagaaac tccatcttga 1380
ataggggctg ggtaaaataa ggctgaggcc tactgggctg cattcccaga ggcttaaggc 1440
atttgtagtc acagaatagg tcagcacaaa gtacaggtca caaagacctt gctaataaaa 1500
gcatgcggta aagaagccag ccaaaaccta ccaaaatcaa gatggtgagg aaattgacct 1560
ctggttatcc tcactgctca ttatacacta cttataatgc attagcatgc taaaagacac 1620
tcctaccagt gccatgacca tttacagatg ccatggcaac gtcggaaagt taccctatag 1680
ggtctaaaag ggggaggaac tctcagttgg ggaattgccc accccgttcc cagaaaactc 1740
atgaagaatc caccccttgt ttagcatgta gtcaagaaat aactataaat atccttagaa 1800
tagaacaaaa gaacaatttt ctttacttct ctaataaact tgctttcact gtactctatg 1860
gatttgcctt gaattctttc ttgagaaaga cccaagaact ctctcttggg gtctggattg 1920
ggaccccttt ccagtaacag ttacacttgc aaagtacatc ctgtgtccaa ccactgtata 1980
tttaattgtg aaatttatta aatattaatt taaataagtt gaaagacctt taaagacagg 2040
gcaattcaaa aa 2052
<210> 86
<211> 701
<212> DNA
<213> Homo sapiens
<400> 86
ataagccaga aaatcggaag agggagaaaa atgaaaaatc agcaacaaaa ctgggtcgag 60
agtgaaaata gctttagtaa gaggaattaa gttcaattct atcgtggccc tgtagctcag 120
cggttggagc gctggtctcg taaacctagg ggtcgtgagt tcaaatctca ccagggccta 180
acagactgcc ctttgggttc yggtgtttac ctacacttct tgtgtcttat ttttatgttt 240
ttttgagaca aagtctcgct cacgtcaccc aggctggagt gcagtggcgc catctcggct 300
ctatacaacc tccgccttcc gggttcaagc gattttttcc cgcctcagcc tcccgagtag 360
atgggactac aggcctgcac caccaagccc ggctaatttt tgtgttttag ggtagagaca 420
aggtttcgcc atgttggcca gactggtttg gaactcctga tctcaagtga tctgcccgcc 480
tcgccctccc aaagtgctgg gactacaggc gtcaaccacc gcgccctgcc gaagggtgcg 540
tttattagat gccaaaacct aaaactggaa attattcaaa tcgataagca cccattttag 600
cccaccttct cagaatacag gaatgtactg gtagcaaaag taggaaatgc tagaaataca 660
ctctggttcc aaaatggcag aagcaagctg gcttcactgc t 701
<210> 87
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 87
atttatccac tcttaaaagg gtatctttaa atagctgtgg tatccttttg tatttcagac 60
attttatgta atttaaattc tgattcatat ccctaatttt aggattaaag tgtttgttaa 120
caactaaaaa gcaaaacaaa acaaaactag gaagtcctta tctgcatctt taagattata 180
tcaaataggc tactgagtgc ttacctgtta acacctgctc caattgcttg caattgtggc 240
taatgtctta aaggtggtag atttctctgc tttccaataa aatcacattg ccagcatctc 300
cagatacaat tattctcatt ttgaatagcg aacattccat tgactagcaa aacaaaacat 360
ttgaattata tgagatatct agcagatcag aaagagacca tagcaattgg attaaaacag 420
aagttaatgg aagagaattt tagaaagctg ctgaggggat ctttatagtt tttatctgtg 480
atcactttag aatgttttaa ygcctagttt agaatactta cctagatgaa tacacatcct 540
tacctccttt cttacctgtg tattggttga ccttatgttt gtcatcttcc tcttgagttt 600
tctgattata tatatatttt taaatttttt agttattttt aattttatta ttattatact 660
ttaagtttta gggtacatgt gcacaacgtg caggtttgtt acatatgtat acatgtacca 720
tgttggtgtg ctgcacccac accaacatgg cacatgtata catatgtaac aaacctgcgc 780
gttgtgcaca tattttttaa tattaaaaaa ggtgaggttc aacagagtct tcaaagcatc 840
tttttaaatt gcactgtgga acaaaaatcg agacaagaga ggcaacaaga gttttagtcc 900
caaatctgcc atccaaagtc actgtataat tgggcgagtt agttaatagc tttggccgtc 960
agttttattt tctgtaacat tataaggttg ctgttttcct c 1001
<210> 88
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 88
attctcctgc ctcagcctcc cgggtagctg ggattacagc agtatgccac cgcgctcggc 60
taatttctta tttatttatt tatttatttt tggtatattt agtagagatg gggtttcgcc 120
attttggcca ttatggtctc gaactcctga cctcaggtga tccgtccgcc tcggcctccc 180
aaagagctgg gattacaggc gtgagccgcc gcccaaccac tttttttagt attttaaatc 240
aagtatcttt ttgtttgttt gtttcttctg tgcctatgct tacccagaca gtttcttcat 300
ttattttccc ccgccttggg caggcttcca ctcttcagac cctttcctgc acaactttgt 360
ccctgagcat aggtcctgga cgtaaaagaa gggacatcgt ctggagaaat attgaattaa 420
gaaaggcgcg gctgtgaaga atagaaatca gtgtctccct tagtctctca gttcggcgat 480
cttggtaatg ccctgtccca ygcctgctaa cgcgattcag cctcgatatc cccgtccagt 540
cccacgatcg caccaagaag agcttgcgag ccttcctgct acatactgac attaagaaac 600
cggacttgaa agggatccca gacaaacgtt aaacatgcaa caagagggat agggtgtaag 660
gaagagaatc cttggggcgg tgtctgataa aacagatggc tctcctttcc aggtgtttct 720
gaatttgatc cccgacgcct ggggcatcgt ggaggaactt gcataggaaa tcaaggtgtc 780
gcaggaaaga gaacacgcac aagcaaaaga taccttaatt tgtagtatac tcaatattta 840
tcgtacagaa gtgtatcgac gatagacaat gtgcgatgtg atgggtgctg ggaacttaac 900
gaactctcca cgcgcctaga cctcattgga tccactttct cttgggctgt gagccggtaa 960
aaaaaaaagg ggtggatgtg gaggacggtc caaaggattc g 1001
<210> 89
<211> 501
<212> DNA
<213> Homo sapiens
<400> 89
tgtggagctc cgccactccc agcccgggtg aaggaaaact gggaaacaga atgaatgtga 60
ttatctattc gaagataaat ttccacaaag catgccgttt gatagtagct tataatgtgg 120
aagtaaggca tcctgtcatc cggccggtta gctcagttgg ttagagcgtg gtgctaataa 180
cgccaaggtc gcgggttcga tccccgtact ggccaagtat tctctgtggc ttttatcacc 240
agaatggata rtaacccaga catcgatcta aacgtgtacc tgtgtgtttc tccaggctta 300
actttgcccc gagaaaacgg atctgtgaat ttggtgcgcc ctcgcttact cgacagcggt 360
taatttgaac ggggacgttt ctttccgctg cctccaaggc atacccacat cctacccgta 420
aaacaaaggg gctataggca ccttacagtg acagaggtac gttacggttg gaggcttttg 480
tgatttttgt cctcctctgc c 501
<210> 90
<211> 501
<212> DNA
<213> Homo sapiens
<400> 90
tttttgatgc ggatcgaaag ggactggccc cggagcctac aacctgacgc aggtgggact 60
tggggaaatg tcgagaaacc taggtctggg acttgagttg gcttccaggg cacacattct 120
tgttcagaag aaacacattg caaaaatcgg gaggtgacgg gcagatgaag tgtcggcgct 180
tcgcctcggg actccagtgc aacctatggg gcttttggaa atgaggaagt cgatgactct 240
gcagggactc mtctgaccca ggagcagatg gcgctcgtct gggcactccc caggagaaaa 300
ggtgcatcgg gaagcagcct ggcttgtgga tggtaataag tcactgttga tgggttgggt 360
gcagggaggg atttaagttc ttgagcgaca gatgctaggg agtttacctg ctctggataa 420
cagtatcttg tggaggatag tcacctggaa aacagaaatg gcgtgactgt gttgaataca 480
ctgtttgatg attctgggca t 501
<210> 91
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 91
tggggcctaa ggagattctg ttgtccagaa ttcagaaaat tctgcctcca gaaatacaaa 60
tatgctcttt tctaaacaag tgacaacaca atgtagccat aggctccctt aagcagccac 120
ctcatgtcaa ctaatagtct ttgctctcta gcctctctcc tccaaagtcc atttcgtctc 180
ctgaggcttc agctattact gtcagaccct cagttacttc tgatgaacag ggattaggct 240
tgagaaaatg gagatgcatt tagattggca gatatggggg acttcttaat gtgcttttat 300
tgctgcctta tctctgaaaa caggttctgg gagtttggga ataagtctga gggcatataa 360
aggattgaga ctgagtgact taggagtgtg agaggaaata tcttgatgtt gagaacaggg 420
ttgatgtgga ggggtattct ctgtgttatg catgtaaaaa gaaaaaaagg aaaaaaaaat 480
cattactggg aaagaaaaca ycccaagctg aagtccaaga aaggtacaca gaggaaacac 540
agaaacagtt gtgttagcag aagatgacat gaaacccagc tgacagtgaa attaggaagt 600
tgccttggaa tttcaagaac ttgcattctc aagtttatgg ttctgtgtcc aacagagcag 660
caaaatccag cacttcttct tttgagtctc catatcgtgc taacagaaag acaaggggtc 720
gggagatgca gagatgagga ggagctcaag agtgacagtg ttgaagagat tctgagcaga 780
actccacagt gatctgtgta actgatatcc aaccctgatc cctccatcgt ctgcctgtcc 840
aacccttgct tagatctcaa tgtaacttca cttcattgtg tccaagaagt tctctgatct 900
cttcccctgt ggatttagca accctccatt ttagaggcat tttcaggaat ctttttgcaa 960
tgcatcatct ctatgaaagc tcagcttcct gctccccagg c 1001
<210> 92
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 92
ttgctgtaat gaaataaaca aaaaaaaaat aaaaataaaa ataaataaaa aaggagcatg 60
tccagtacta cgtcataact gaagaatggt agactgcatg aaatctagaa atgagtgaaa 120
aagaattagg ctttgtcagt atgtttcttg caatctccat ggaagggagt gctctgtttc 180
caatgaggaa aatataaatt tttctagtct ggccaaagac catttattca ggtaaatagt 240
tgttttttca agacatagct gtaaaaaaaa aaaaaaaaaa aagtccttta ggaccagatt 300
ctctcatata attctatgtt ccaatctgtt cctttttgcc ctacaaattg ttcttcagaa 360
aaaaaaatat atatatatat atagacatat atatatagac atatatatag acatatatat 420
atatacatac acaaaaagtt atttggggca aaacatgaat catgtgcttt cttgaagcta 480
ccatataaaa gttccagtgt raagcactaa catgacaacc tggtttggat tagctctaat 540
caattcccca aggctcatta gcaatgtcat aaattaatca agattgtttc agcaacagag 600
ggtaccatgc ttggctatca ggtgcaaata acttaaaaga tctatctttg agtccttatt 660
tctctttatc tctctgtttt agaaatttta acttcttaat aactgagagt aatgggcctg 720
atatgtgaac tttgtaaaga agtgttcaat ttttttctga atgcttctct ccattctcca 780
cacagatttt agccaccgca cacacaatat tcttctagac atcttcttcc ctgctgacaa 840
ttccaggtta ttcaagtagt ccctgatggc ccaaacttca tatagacata tagatgcaga 900
aatatagaca tctatctata ttctctgtat gtttaataag gagtcacttc actattcttt 960
attctggcct ggagaatgtg tttaggtatc ttaatccttc c 1001
<210> 93
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 93
cgcttgtaat cccagcactt tgggaggccg aggccggtgg atcacctgag tcaggagttc 60
gagaccagtc tggccaacat ggtgaaaccg tgcctctact aaaaacacaa aaattagctg 120
ggcgtggtgg caggcacctg taatcccagg tatttgggag gctgaggcag gagaaacgct 180
tgaacccttg aggcggaggt tgcagtgagc caagaccaca ccaatgaact tccagcctgg 240
ctatcaagag cgaaactcca tctcaaaaaa taaataaata aaattaaaaa ataaaaaaag 300
aaaaagtaag gtattctacc catgaagctt gaaagatcat gctatacaaa taaaaaactc 360
tcatcttgga ttgacctaga tgagtttgta ggccaaggca aaaattacac ttctactgca 420
gagactgaac cctgcttcat acaaaacaaa agatacttga aactgtacta atgctaggaa 480
gaaagacatg atgacaagct vagagtgtca attggcagga caggcatagt tggggttctg 540
gggtttttct ggggacagaa ttactgggaa attcactgat cttccccaca tgcagaataa 600
tctgccatca gattctataa aacaagtttt tctactttac tttgaaactt tgaagaagat 660
agccccacaa aatattatca tattgcagaa aattttccta gatcattaaa gtaaaagaaa 720
tgttaattaa cagtaaataa cttgttaaac ttaaattttc cctctgctca aaataacttc 780
ccttcttctt caccacaagt ttactcaaat tttagatata cctcaagaat aatcttccct 840
tgggaggttt cctcagacca acgtgagtta catgtccttc ctctgtttcg atttgtcacg 900
acaaaaatat tatatgtatg aatttctaca tggaataaaa gtaggatttt attcttaaaa 960
aatatagttc ttagattttg ctctgcaggc attgagtttt t 1001
<210> 94
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 94
ttataaaaac tgatacagga agtaatagaa aatttaaata gtgctattaa acaaatgaat 60
cagtaattta aaaaccttct tacagagaac actcccagct tatactgctt caaaggtgaa 120
ttcttccaaa tatttatgaa acaaataaca tgaatcttgc acaaactctc aagcaataga 180
gagaaaggaa cacttcctaa aatattttgt aagacaagca tactcttggg tatcagacat 240
atcttatgtg ccacctctga ttctcttgcc atcttacctt gcaacttgtt ttaccccaat 300
agtcatggca atcaatttcc tctgagtgca gaaaacaaca ggacttcact gttcacctct 360
gttgaacttc tcgtcttctg ctataaggct tctctgctgc tgttgaaaca tgagctgctg 420
agcgatcttt gatatctgca catgcccaac ttctatatgt agggctatta atgctctatg 480
gagcaaaact ttgatcagtt rgatatagta gctgaccaat aatttttttt tttttttgag 540
atgtgtcttg ctctgtcacc caggctggaa tgcagtggca tgatcttggc tcactgtaag 600
ctctgcctac ccagttcaag caattctcct gcctcagcct cccaagtagc taggattaca 660
ggtgtgcacc accatatcca gctaatcttt gtatttttag tagagatggg tatcactgtg 720
ttagccaggc tagtcctgaa ctcctgagct caactgatcc tcccgctttg gcctcctaaa 780
gtgctgggat tacaggtatg agccaccatg tccagccgtg accaataaat ttttcccact 840
ttcttcccct aaatagcctt ccctgagatt acactcctta atacattaat aatacattat 900
aatttgattc agtggatgct gtttacatga gtgtgttcag tttgtgaaac ttcatcaagg 960
tttacactta caggtggagt tttatgtgtg tatgttatgc c 1001
<210> 95
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 95
aaaccacatc tctactaaac atacaagaat tagctggaca tggtggctca tgcctgtagc 60
cccagcttct cgggagggta aagcatgaga actgcttgaa cccaggaggc ggaggttgca 120
gtgagtggag atggcgccac tgccctccag cctgggtgac agagcaagat tctgtgttaa 180
aaaaaaaaaa aaaggatggc ctttttcaca gcctaatgcc cttgagatcc atccaatttg 240
ttgtatcaac agttcctgcc ttttaattgt tgagtagttg tttatagtat ggatgtacca 300
cagtttcttt aaccatctac ctattgaggt acattttagt agttttctag tgttttgcta 360
ttataaataa aggattacaa ataattgtga tagacttttg tgttgacata gttttcatgt 420
catttttatt atcgttatat attattgaat atatacaata tatattgaat gctacacatg 480
tagcattcac gtttctgttt yataaaatgt ctctgtttca tcactgtgaa atgcctcctt 540
ttctttttta ttatgtcacg tctctatggt aatactcctt gtcttaaaat ctacacttta 600
tgttaataca tacgttttat gttaattttt ttatggttcg cctttgtggg gttttttttt 660
tttttggttg ttgttgtttt taactttatt ttattttatt tattttattt attttttgag 720
actcactctg tcacccaggc tggagtgcaa tggcgtgatt ttgtctcact acaacctctg 780
cctcttgggt tcaaacgatt gtcatgcctc agcctcctga gtagctggga ctataggggt 840
gggccaccac acctggctaa tttttgtatt tttagtaaga gacagggttt caccattttg 900
gccaagccag tcttgaactc ctggcctcaa gtgatctacc tgcctcagcc ttgcaatgtt 960
ctggaattac aggtatgagc taccacaccc agcctaacct t 1001
<210> 96
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 96
tgggtcaaaa tgacaccgga gaacggatac tggactatgg gcctgactga tgggaataag 60
tatcgggctc tcactgagcc cagaaccaac ctgaaacttc ctgagcctcc taggaaagtg 120
ggggtcatcc tggactatga gactggacat atctcgttct acaatgccac ggatggatct 180
catatctaca catttctgca cgcctcttcc tctgagcctc tgtatcctgt attcagaatt 240
ttgaccttgg agcccactgc cctgaccgtt tgcccaatac caaaagtaga gagttccccc 300
gatcccgacc tagtgcctga tcattccctg gagataccac tgaccccagg cttagctaat 360
gaaagtgggg agcctcaggc tgaagtaaca tctctgcttc tccctgccca gcctggagct 420
aagggtctca ccctccacaa cagccagtca gaaccataaa gctacaggca cacactgaag 480
cactttactg atattcattc rattattcca taggacagtt gtttgagttt ggtgccacct 540
tattggcccc tttatacaga taaggaaact ggggtgtaga aaagtgtatt gactttacaa 600
agcagacagg aatagtgaac aacagagctg ggatctgaac aacaatgact aacattaatg 660
gagaatttaa aacgttctga gtgctgtgtt atgagctttg gtgggtgtca ctcctttaat 720
cctcacaaca ccctgtcagg tagtctcatt tggcaagtat ggaagcagag gcagggcaac 780
attaagtagc ttacataact cacacggtaa tttgtgcagt tgggagatgt tcagcttcag 840
tccctggcca attgcccgtt cttttccagc ctgatttttc ctgcatggga agagcccaca 900
tgtagccctg aggttccctt cccaggacag ctccaggatc gagatcactg tgagtggttg 960
tggagttaag acccctatgg actccttccc agctgattat c 1001
<210> 97
<211> 2802
<212> DNA
<213> Homo sapiens
<400> 97
tctttctaca tttttgttgt ttccctcccc acattgattc tgcccactga tgctttatac 60
tcagaggtta attttctttt cttttctttt tttttttttt tttttttttc ttgagacaga 120
gtctcgctct gtctcccagg ctggagtgca gtggcgtgat ctcggctcac tgcaagctct 180
gccttccggg ttcatgccat tctcctgcct cagcctcccg agtagctggg actacaggtg 240
cccgtcacca tgcccggcta attttttatt ttttgtattt ttagtagaga cggggtttca 300
ccgtgttagc caggatggtc ttgatctcct gaccttgtga tccgccctcc tcagccttcc 360
aaagtgctag gattacaggc atgagctgct ghgctggccc tcagaggtta attttcaatc 420
ttcactcgac cactcgtgag ctaaatgagt tccccttttc tgcagtctat ttttccatac 480
atccaattta tttaacaagg tggagcctca tctgaagcat ttcctcacct gaaaaatggg 540
gataaacata tgaatctcta gcgctgtaga aggcaatcat attatttact cagcccacag 600
caggccatga aggaagctcc tcatcttcct gatagctgca aggccgtctc tgtgctgggc 660
tctgtgtggg gccttatatg ccctagattc actctccagc cttcagcttt ctccaccctc 720
ttctggaccc caggaatctg tcctctatgg acagtgccac tgggctccct tgtcctctgg 780
tttgctgctg tgtttggcca atgggaggcc ctgatagaag attagaagga gaaagaaagg 840
agatacacac cgtttaattt cctgcttcct ccctgccagc agcagctggt ggtgctctaa 900
caaggcccga ggactcttct caggaagctc cctcgttaag ctacctcttt ctctgggttc 960
cagtaattgc ctcccctttt tagccctccc aggctagggg tggagacagc tccccactgt 1020
tgggaaccat gggggcactg cacttttcct tgttgctttc ccttaaccct tctttctgga 1080
aaccttgtcc aactacccag tttgagctca ccatctattt cttgctaggt ttctgccaag 1140
catgttcatt attccttcag tcttcacctc aacccccatg aaaaacagat tgcaatcatc 1200
atctaaaaat gtggaggcca aagcttggaa gcattaaatc ctttgaggag atacaggcag 1260
taggtggcat gagaagcctg ggaaggacaa agttctttgg gcaggcatca cctcctctcc 1320
ttggcatttc catcctcact ctccctgcag tattactcag tgtgtgtctc cttcccttca 1380
cctccaccct ttatgcgtct tcctacccac gaaggaagtc aagggaactt ttctgctcca 1440
aatcacaaga gttggagaag aaaaaaggaa aaaggaatat agtccctcag gttgttggtc 1500
cagggaacat gcagtgattt actcaccagg cttgaagagg gccatttttc cattctgaaa 1560
ggaaggagac acagataaga aaaaggtcag tatttttgta cttttcccac tccattctcc 1620
tctcactaca tgttttctct ccttttcttt agagtctctt ccagggtcca gcttccctcc 1680
tctacagctc tgatggatca gaggtggcac cttctcaaaa atgtcaggct tggctccctg 1740
tgtcatgggg ggtgcaggat gcatggccag gctttacaag ggggtgtgca ggatcaggag 1800
tttctcagag gctccagaaa agcggaggtg aacccccacc acacagaaat tgagtcttta 1860
gattagatct aattaatcca gctgagaaca tccacgggtc acagtggaga aaaagttgaa 1920
atattcaggg catgtgaccc agcaaactta cagagcatca ggctgactta ttggtatcgg 1980
acgaagactc ctctccacct acaatgaaag aaaggtagag gtgtcaccag aactctgcct 2040
tttctgtgtt ggccccttcc ccttcttttt gcatccatct agtctttttt tttttttttt 2100
tttttttttt tttttttttt tttaccatcc cacccttccc catggtctcc atcttcaggt 2160
acaattcttt cttcacctct tcttaatatc aagtctggga acatcggttg aacgctagtg 2220
gcagggcagg cactgtgaga gttccttccc aatggggtcc agctcatctg ttttgaatgt 2280
gtacctgggc ataggtgtca ccatgtctat atgtgtatgc ctaggagtac aagattcatc 2340
cttctcaatc tgtatcattt cgtaccttgc tctaaaaaga atttgggaaa tttaatgagc 2400
aatttcaggg actagttttt gaaagcagtt atgatctatc tgtaccaact gagccactgt 2460
agctactcct ctttattaga cacacttttc tccctccctc tctcttttct gattttctta 2520
tttcttaaat cttccattct tgttttcctt tcaacagcct ctagattatg ggaaacaaca 2580
agtaagtttc ctgccataga aaatgcacct catccttctc ttccctcttc cttttgaagt 2640
gtacccctgg atattcctca gtgcttttta gagcttaagg gtctgtagcc cctagtacaa 2700
agagattgaa gacctctttt tttttttttt ttttttctag agagaaaaag cactgggtgg 2760
tttctccaaa gagccacact tgttttcttt ttctgggtaa ag 2802
<210> 98
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 98
tgggtgaaaa caagaaaaac ttttaaaaat ctactctggc atcttttgct agcaggcatt 60
gacaattagg agaaggcaag gtgttaactt ttactgatct cccacttttt tttttgagac 120
aaggcctggc tttatcaccc aggctggagt gcagtggtgc gatctcagct cactgtaaac 180
tccgcctacc aggctcaagc catcctccta catcagcccc ctaagtagct gggacaacag 240
gggcgcgcca ccactcctgg ctaatttttg tgctttttgc agagacgggg ttttgctatg 300
ttgcccaggc tggttgcgaa ctcctgggct caagggatcc gcccgcctcc acctcccaaa 360
gtgctgggat tacaggcatg agccaccgcg cccacccctc tagtttccag tttagtcgga 420
aagattaaaa acgccagcct tgttttccta gtgctgtttt tggtttttac ctcgggtctt 480
ttgtcgtgcc ttaaaatcat rtctggttgc gcaagtgagg gaaaggattg ggtaaagggg 540
gcgccaccgc aagttgctgt gcaacatcca gacatcacca gacccaccac ctggagcctg 600
gcctggcggt gtcaaacgca ttctggtctc atctttttag aaacccgtgg atgctcaagg 660
aatttccgga taacgtgatc ccggatgcgc ttgactgact tacacggaac gagcaaagcg 720
caaagcagtc cctgctaagg acttagttta tgccctcaag cgcaaaggtc ggaccctcta 780
tggtgttggt agctatatgc acgtacctca tgtacatttc accttaaatg gctttcaaag 840
agctagatta atttagtgga tagatcaaaa tgatttatga cccctcgccc cccagtgata 900
ggaagagcga accagctctt ctttagataa tagtgagtgg ctctgaaaag agcctttggg 960
ttggacaaga gcttgagaat ttacttggag ctggtgtact t 1001
<210> 99
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 99
atttagtgga tagatcaaaa tgatttatga cccctcgccc cccagtgata ggaagagcga 60
accagctctt ctttagataa tagtgagtgg ctctgaaaag agcctttggg ttggacaaga 120
gcttgagaat ttacttggag ctggtgtact tggtgacggc cttggtgccc tccgacaccg 180
cgtgcttggc cagctccccc ggaagcagca ggcgcacggc ggtctggatc tccctggagg 240
tgatggtcga gcgcttgttg tagtgcgcca ggcgggaagc ctcgcttgcg atgcgctcga 300
agatgtcgtt gacgaaggag ttcatgattc ccatggcctt agaagagatg ccggtgtcgg 360
ggtggacctg cttcagcacc ttgtacacgt acacggagta gctctccttg cggctgcgct 420
tgcgcttctt gccatccttc ttctgggcct tggtcaccgc cttcttggag cccttcttcg 480
gggcgggagc agacttggcc rgctcgggca taatgaaaca atagtggcaa aaccaaaaca 540
agaagtcggt ctcctctttt tatataatag tttatgcggc cgaggtagtg ggaaggtctc 600
tgctgattgg taattatccg tggatgacga cagatgccag ttttgcccaa tcaaaatagg 660
tatcctgcat aatcgagtcc tattggtcta aataaaaata aaacgtaagc caatcgcaca 720
gcttcctttt cgcgcccagt agaggctata aaatgtacgt ttttctagtt tcacttcagt 780
ctttcttgac cgtatagata ataggccttt tgccatgtct gggcgtggca agcagggagg 840
caaagctcgc gccaaggcca agacccgctc ttctcgggcc gggcttcagt ttcccgtagg 900
ccgagtgcat cgcctgctcc gcaaaggcaa ctatgcggag cgggtcggtg ctggagcgcc 960
ggtgtacctg gcggcggtgc tggagtacct gaccgccgag a 1001
<210> 100
<211> 1366
<212> DNA
<213> Homo sapiens
<400> 100
ggtatttcct atgatttcat aatagacaaa ggtttaatta cacaactcct ggctgaatct 60
agagtactaa aatgtggctg ttagaaaagg ttgctctctg ggcccgatgc agtagctcat 120
gcctgtaatc ccagcacttt gggaggccaa ggctggcaga cagctttagg ccaggagttg 180
gagaccattc tggcctatgt gttgaaaccc cgtctctact aggaatacaa aaaattagcc 240
gggcgtggtg gcacacacct gtaatcccag ttacttgaga ggctgaggct gagaatcgct 300
taaacctggg acacagaggt tccagtaagc cgagatcaca cctctgccct ccagcctggg 360
tgacagagtg tcgccaaaca aaacaaaaca aaacaaaaaa acaaaaaaaa agattgctct 420
tacccaggga tgatggtcag atgcaattac aggttatgaa tttggcataa aagtaatgct 480
aagtgtttca cactgcactt actgttgtca gtgttctaag tgttttttat ttaccaattc 540
atttacactt gtttgtcttt tttttcaggt ctccaactcc tgggctcaag ctgtcctccc 600
acttctgcct ccccaaaagc tgagattaca ggcgtgagcc acccggccct actcatttaa 660
tccttacaac aacccttaga gctgggaact atttttatca tcatcacata attgtttaca 720
aaaataaath gaggcttaga gagcatatgc acctcaaccc aagatcccac aagtagaata 780
ttattgttac agatttggtt gcaaataatc tgcttcttat gattgtgctt taaatttttc 840
accgtgtcac atcactttgg tggtgtaaaa ttataaaaca acatttaagt cttaacttta 900
aaaatgtgtt tttggcctgg tgcgatggct catgcccata atcctagcac ttggggagga 960
tgaggcagtc agattgctta aggccaggac tttgagacca gcctggacaa catggtgagg 1020
caatttctct actaaaaata ctcaaaaatt agctgggcct ggtggcctgc gtatataatc 1080
tcagctactt gggaggctga ggcacgaaaa cccaggaggc agaggttgca gtgagccgag 1140
atcctgccac tgctctccag cctgggtgac agactaaggc tctgtctcaa aaaaaaaata 1200
tatatatata tatacatata tatatatatt tatatgtata gacatacata gttaaaatat 1260
atatattatt ttttacatct taaagagaaa cattatttat atgcaaaaaa ttttatttag 1320
gcccacttag caattccaga tctgacaact tttgaggatt taaaat 1366
<210> 101
<211> 528
<212> DNA
<213> Homo sapiens
<400> 101
aacataaaac tctaagcatt tattcaaata tattagaaat ttaaatgaca taaaaattgt 60
taagtacttt atttggacta gtgcaaatag cataaatgtg aatttaaata tatacaaaaa 120
gttaagtaat tgaatatcaa taaaatatta ataaacagta aatataaatt ttctatatgt 180
gactagtgag atctactaag ctagtctagc catttttctc aattatctcc attatttcct 240
aaagtatcct gtggagtaac tctgattgcc tttactctca ttaaaaagat gaggaaatta 300
agacaaaaac agcaaaagta tctgcaayga agccacaatt tcagtctagg tttgtttgat 360
tgcagaggct gaactcacta ttctccaaag taaatattta catggaaaca ctaaaaaaca 420
aagaaattac attttaaatt gtgtcaagat tacactttct ttagagttaa aagaattcca 480
cagtgtatcc atgcatgtaa aaaatattaa atatatgaaa agacgact 528
<210> 102
<211> 801
<212> DNA
<213> Homo sapiens
<400> 102
cagccttctt ggccttctta ggcgtggccc ccgcgggctt cttagcttta gcggcgcctg 60
ccttcttggc tttgggcttg gcttccccgg aggccgcctt cttgttgagt ttaaaggagc 120
cagaagcacc agtgcccttg gtctgcacca gggtgccctt gctcaccaag ctcttgaggc 180
ccagcttaat gcggctgtta ttcttctcca cgtcgtagcc accggccgct aaggccttct 240
taagggctgc caaagaaagg ccattgcgct ccttagaagc agccacagcc ttggtgatca 300
gctctgagac tgggggcccc gtcgctttgc gcttagcagc gccggcgccg gcagccttct 360
tagttgcctt cttcttagcc ggggatttct ccaccggcgc yggggtggct gtctcggcag 420
gagcggtttc cgacatggtg gcaagaaact gctagaagag aataagctcg aaatctaaag 480
agcaggtttt gcgttgctgc tatgctcggg ccccgggctt atataagccg gcgctgccct 540
gtgattggtg gagcgtccaa tccaccgccc tctggccgcc gccgctcgcg gttggactcc 600
caaattgtgt ttgttagtcc tcaaaatttg attaaatgct taaaacaatg gtacagaatt 660
tggcactttg aagctccaaa ggaggaaaac agcctccagg ttcacatact tgtttgtgtt 720
ttcaagaatc ttgtgcaatt gatgaaagat attttaaaaa atcccttcag cttttcataa 780
gaatccattg ggctgagggc a 801
<210> 103
<211> 1092
<212> DNA
<213> Homo sapiens
<400> 103
gatttggatt cctaatgaaa tcaacagtca cttatttctc attcttgaaa tgctgtgcaa 60
gaaaatttaa agtagccaat gcacttcatc ttctaagaac tcctggagaa gttggcagac 120
tatggccaaa tctggacaat ggcttttttc tgtatggccc tcaagctaag aagtgtcttt 180
atgttttaaa agtattgtta aaaaaaaaaa aaacaaaaac aaaggctggg cacggtggtt 240
catgtctgta atctcagcac ttggggacac tgggataggt gggttgcttg agctcaggag 300
ttggagacca gcttgggcaa cttggtaaaa ccccatcttt aataaaaata caaaacattt 360
tgctggatgt ggtggcacat gcctgtagtc tcagctactc gggaggctga ggtgggagga 420
tcacttgaat tcagggtgtc aaggctgcag tgagcaatga tagcagcact gcactccagc 480
cagggcaatg gagcaagatc ctgtctcgaa aaagcaaact aactaaaaac taaagagtgt 540
gtgacagaga ctatatatgg cctttaaacc ctaagctatt tattacctag cccttttgct 600
gtgttataaa tttctccaca gagacacaga tattgtatag gcctcttacc gaacaatgca 660
aattgagaac taaagaaaag gagatcttca ygagcaaatg atctaaccaa gcactttcca 720
ctgttccaaa cacaaaactt agaaggtcca ggagaaaaaa accccaaaac tccatgtgta 780
atggagccag ggtataacaa taagagctga cactcattca gcatttacta cctgacagga 840
agtaatctta aatatgttct acaggtttct attaatttgc tacatttaca gctatacaag 900
atgaggccca gatagagaat taataacttg tcaaaggtta tacagctatg aagtggcagc 960
tctaaatttt aaacctagaa acatggcctc agctctatta tggagggaaa atccttgaag 1020
aggtgagaag agaactatct tcaaagcttg gaagaggcag tgtcaagttg ttcctacacc 1080
tagcaaacag cc 1092
<210> 104
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 104
gatctcaggt gatccgcccg ccttggcctc ccaaagtgct gcgattacag gtgtgagcca 60
ctgtgtctag cctatattgc cttttaattc ttgtttttta caatgatggc aatccataat 120
gttattcaat tgttgtttaa tcctttcata agaatgttat tctagttttt ctggtaatta 180
aaaagacagc tctggaaact tccgtagact tacctataaa tctgttattg ttttgatttc 240
atatcacttt taaagattgt gtacattttg ttttgttttt ttaagtaatg tggtccagct 300
agtcacccag gctgaaatgc agtggggcca tcctagctta ctgcagcctt gaacttctgg 360
gctcaagcta tcttcctact ccagcctccc aagtagctgg gactatagac atgaggcacc 420
tctcctagct tcacttttaa aggttttaaa atctaatctt tctctggttt tagcttgctt 480
aatacaaaat tcaattatgt yctataggaa aaatttcctc tactttggga tcttggcagt 540
gatcctccta gaaatggtga tgggcaaaac aaaaggcttt tgattttgtt gaaatgtgtt 600
tgataggcta cattaaagcc acagcacaaa gaaaccttgt agagcaaagg aataaagaaa 660
ttattgatga aactctgaat cctggaagga aactcaaaga tcatcttact aaaccctacc 720
tttatttaca tttgaaggaa tggaaaccaa gaagtatttg tgaaaaacat gctgtcacgc 780
cagaacccag atctctggga ttcctgtcca atgtgtgtgt gtgtgtgtgt gtgtgtgtgt 840
gtgtgtgtgt gtttgagaga gagagacagt gtgagagtag gagaaaaagc aggaggaggg 900
gaaggcgaaa agggagagag aaagcacaat tctctcattc catatatgta ttgagtgcct 960
actatatgtc agggatacac caataaatga tatggattgt a 1001
<210> 105
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 105
cacagcacaa agaaaccttg tagagcaaag gaataaagaa attattgatg aaactctgaa 60
tcctggaagg aaactcaaag atcatcttac taaaccctac ctttatttac atttgaagga 120
atggaaacca agaagtattt gtgaaaaaca tgctgtcacg ccagaaccca gatctctggg 180
attcctgtcc aatgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtttgagag 240
agagagacag tgtgagagta ggagaaaaag caggaggagg ggaaggcgaa aagggagaga 300
gaaagcacaa ttctctcatt ccatatatgt attgagtgcc tactatatgt cagggataca 360
ccaataaatg atatggattg taacacatat ttacttttgt aaatgagcaa ttctattata 420
aaagataaat atgcttttag ttagtaaaat gtaggcaaaa atgcttaaga tgttttaagt 480
agacataagt agttagtaaa magagcatat gttgttaaat atagatataa gggatggaag 540
ggtcaaaaga tacctaatgt tcctgatgca caaaatatac aaaaggagcc acacattcag 600
aattcacaga tatatgagac atcgaagcac tgactcatta ttcatgaggc cttgagtcag 660
ccacaaattg gagacaccat aagttctcta ctttaggaac aaaaataaaa tccatggcta 720
ttcaaccaac taattggttg ggtccaggca tatatatctc tgtgtctatc ctacaggctg 780
attgagcgat gtaaaagaga tcagatatac ggaaactgct cacacttgag tcagatagtg 840
tggttcttcc aattcactta cacactaaac cattaacttg ctcttctttt tccccttgct 900
gcttgctatg ttttttaatg aagctgtgat ttgagcattt cactgcatag tctgcaaacc 960
tatttgtgct gtgtcctctg ggagagcttg catgggacta t 1001
<210> 106
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 106
tattgagtgc ctactatatg tcagggatac accaataaat gatatggatt gtaacacata 60
tttacttttg taaatgagca attctattat aaaagataaa tatgctttta gttagtaaaa 120
tgtaggcaaa aatgcttaag atgttttaag tagacataag tagttagtaa aaagagcata 180
tgttgttaaa tatagatata agggatggaa gggtcaaaag atacctaatg ttcctgatgc 240
acaaaatata caaaaggagc cacacattca gaattcacag atatatgaga catcgaagca 300
ctgactcatt attcatgagg ccttgagtca gccacaaatt ggagacacca taagttctct 360
actttaggaa caaaaataaa atccatggct attcaaccaa ctaattggtt gggtccaggc 420
atatatatct ctgtgtctat cctacaggct gattgagcga tgtaaaagag atcagatata 480
cggaaactgc tcacacttga ktcagatagt gtggttcttc caattcactt acacactaaa 540
ccattaactt gctcttcttt ttccccttgc tgcttgctat gttttttaat gaagctgtga 600
tttgagcatt tcactgcata gtctgcaaac ctatttgtgc tgtgtcctct gggagagctt 660
gcatgggact atacttggag cctaccaggg catcaaggta atttctcaca tggtaccaat 720
aaggaccctc tatcataaca aaaatgtgga acagtcacct ttagacagca acttgcagga 780
agtgagggaa aaatgatgga ggtgtgttcc agtcagaggt aaaataacgt agaggggctc 840
acagggacac aatgctcagc agtttgagga acatcaacgg ggccagggta gctagagtag 900
aggaaacaag taagacagcc ctaggagatg aggccaaata catcactggg gccagagtat 960
gcaaaacttc atagggcaag gtaagggctt tggaagtttc t 1001
<210> 107
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 107
agacttcttt agttgtcctt taggatgtat gtcctttagg acagtgacca tgttcttttg 60
tattgactgt ttctccaagg acacattcaa tgataatcaa tgtggaggac ttccgagata 120
atgacccttt gccatcacag gctgtctacc tcttctcagc attaagaccc tctgcttatt 180
cacatgccca cagctctcga gggaagaaaa gaagtctaga aatacccaac caggcgcatg 240
gacaaattgg cctacgtagg ccttcctcca tgcctcccct tcccccaaac ccacatttat 300
tttcattcct ttccttctag tctggcacaa catgtcagta aaaaggacac aagactagaa 360
agcaaattct gagatttgga gcatctgtct cagaataagc agttgcaata tgccttatct 420
ttcccagaat atgttcttgc tccacatcta acaataaagt tccaagaagg ggaattcgtc 480
aacatctctc tgactgattt racaaggtga agacatatct gtttaagagg tattgctggt 540
agccagacga gagaagctat tgagacatct gcagtgaggt acctgttgca aagccccacc 600
gagaaggtgg ctgcggggaa ctcattcctt ctttgggatc agcatggttc tgtattacat 660
ttttagaaga gctgagtttc catgtgttct taaggtctag gatgtataca ggagctccag 720
tatcacagtg gaccccacag aagtggccaa ctacttacat ttcaatatcc ttctctgctt 780
ttttgtttat cagaccaaag ctgaatgtga atctgatggc tgctgcttta gttcaaagcc 840
aatggagtgc tatacctaca gaagcagaac tttaataaac tggcctgagc aatagcaaat 900
ggggaggact tctgaattaa cgaccctttg ccatcacagg ctgtccactt cttctcggta 960
ataagaccct ctgcttattc acatgtccac aggtaacctc t 1001
<210> 108
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 108
cagtgccagg tattttaaaa actctcttaa aagttttcat tatcacgcac ttgtgtatac 60
ttattctgta taagcgcttc tatatacact tcaacaatgt ataatttggt tttattttca 120
ttttatttat ttatttattt atttatttat ttatttattt atttatttat tttaagaggt 180
agggtctcac catactgccc aggctggtct tgaactcctg agcttaagca aacctcccat 240
ctcagcctcc caaagtgcta ggattacagg catgagccac catgcccagc catggtttta 300
cttctgagtt taaaaaaaat gttattatat atgaaccttc tgagacttac atttctaaaa 360
ttcaaccagg tactgtgtgt acctcaataa atgcattatt ttgaccatga acatgtagtt 420
gcctctagta tttttatcta ttaaaaatgg cattttttcc attctcatat gtctcctgtt 480
gcatgtgtgc aaaatattct ytcatgtaaa cagctaggaa tcgaatggtt gggtcactgg 540
agtacactta ctggataaaa aatattatca aaaaccttca gcaaatacaa tttgatgtgg 600
aagagttccc acactgattc ttggcaaaga ccaaaatact tttaaatatg ccactcctaa 660
gtgtttaaaa tgaagacact cattttgatt tcctgagttg ggggtggggg aaaacaatgg 720
agaacagccc ttctcctcct ctattttttt ttcttttaac atttcttcca attactagag 780
atacagtaaa cgcaagtgac acagacaaga aaacatggag cagaccctaa cagaaaaagt 840
agggaataga aactatgttc ataaatagga attccacaca agagaattat gggaatgagt 900
aagacagcaa gattcctcca aaaaacctgc actgccaaga attttcccaa ctagaacact 960
caccagagaa aacggtggcc aagtttcaaa ctgccctcgc a 1001
<210> 109
<211> 1204
<212> DNA
<213> Homo sapiens
<400> 109
tagagctgtg ttcagtttta tctgatagtc gagtcatttt gcaatggcac tggaatgctg 60
tatggagatg aagcaaaact aaacggcttt tacaccacat tgttttgaga tagaaagtag 120
acattgaaat gtttacggta catcaagaaa tttaggcgcg gcagctcgcg cctgcaatac 180
agctgaaaca ataagaaaag tgaggcaaga gaataacaaa gggagctgaa agttagaggg 240
cagaataagt aaaagcaaag ggcagaagta aggtagatgg gcgggtgaac aagaagcgag 300
ataacaagca gtgaaccttt tgcagccgaa acaaaagaga taatgtgagc aaggacctcg 360
tggccggcaa gatctggaac aaaccagttt aagaggcagc tcttcagaga tgggcatgcg 420
tattagagag gaaaagtatc cttaacaaaa gcccgtatga taatcagcta cttaaggttc 480
atgcatatgg gctacatatc atgcatatat ttaagattat aagatagagg cacaagccac 540
agaggacaaa gtaagcaaca aacctatcaa taaaagggca gatgctggct atagattagg 600
cagcactggg aacagaaaac atacacacac gcacgcacac acataaaatg actcaaacta 660
cagcaagctg acgctgatct cacctcgcag aggtcagtcc gctctctccc rcccccgaga 720
gtgtaatact ctgtttacta aacttttgct gctttgcttt gctatctgtg tgtgtgtcgt 780
ccaatttcta ccgggcacca agagcctgga actgtttggc accatccggt aaacagaacc 840
gctttgggaa gccgaggcgg aaggaccgct agagccttgg agttcgaagc cagcctgatc 900
tttacaaaag taaaataact aaccgtgcct ggcgtctcat agcctgtagt cctagctact 960
cgggaggctg agaccagaag gatcacttga gcccaggagt tcgaggctgc aatgagctat 1020
gattgcacca ctgcagtcca gcttgtgtga cagagcaaga gtgtttcaaa tgaacctagt 1080
gtcagatatt tactttctgt attacagagg actgaaagct agctaaataa tacttttcag 1140
tgtacctggg ttccagagat aaaattggta aactaacctt tgctccttac ttgggctttt 1200
agtt 1204
<210> 110
<211> 1538
<212> DNA
<213> Homo sapiens
<400> 110
agattttaaa catgtttctc aggtatccat ttatgaaact aaaccggtaa gcagtgtatg 60
ccaacagtaa gccttaaaag ggcgaggcaa ttgtcatcat ccaatatttg tcagtaagcc 120
aaactgtcat ttctctatgt accaggatgt taccttttaa ggaggagtac tccacaaata 180
tgaaatatgc aactggggga aaattagctg atcctaacca ttttgtagta tctgaagcaa 240
gaatcaacct tattaattta cctagattta tcctgacatt tatgtgtttt catctttttg 300
catttttctg tgctggactc tccttaagat ttttggaaac ctgtgttctg aattcctccc 360
tttccctggg ctagagtggc tggaggcttt ggctcttggg aatggtctcg cgtccttcac 420
cagaacttac gggaatcatg tttggctgaa gagtcggaga cctctccaga gtcatctttt 480
ccagttagga tagaaacgag cccccctcct cacctcgcaa gcccgcgcca gtccagtttt 540
agccgttctt ttggaagagc aagtcagttg aacgccatcg aagaggctcc tgatttagat 600
attaattgtg cttaaatgca gatgactccc cactctcatg cgttccctta tttcccgttg 660
cttctcccat tggcatttac agacttgagg ttgcttggac tctcaattca atactccttt 720
tctgcgggtt cgtgagaatt aggtgtgaac gtgatgtccg cggatatcag tggctagtgg 780
gcaagctcca gcgcccagga actttgagtc gcttgtctag gagtcctgta ttgaattgca 840
acactaagtg caatattctg gttcttgttg tgttctgaaa gagctctttc actcatgagg 900
agagacctgc acgagactgt gaagaccaac tgcttctcag cgctccacgc atccattatg 960
agttcaccgc aggattttac ctgmaaaaat tttgcgtaga ttaagtcacg cttattgcct 1020
cctacttttg tcagtgaaca ttatgtcaca agcattttcc cagaactatt acagtcttcc 1080
agcatgtcgt ttctagtggc ttggtaatga cctattaggc agatggagca ataataataa 1140
taaacaactc tcattttaat atctattttt cactatcaca attagaaata aaaataaaga 1200
ttcctgcata gtatatgtct tcctttggtt aagcttattt cctggctggg tgcagtggct 1260
cacacctgta atcccagaac tttgggaggc ggagatggaa gaatggcttg agaccagggg 1320
tttgaacaag gagtttaaga ccaggctggt caacacagtg aggcgccgca tttctattta 1380
taaaatataa aacaaacaaa caaataaaaa gattatttct ctaggagagc ggttctgaaa 1440
cttcagtggg catcagtacc agcaggatga cttgtttttt gtttgtttgt ttgttttttg 1500
agatggagtc tcactctgtc tcccaggcta gagtgcag 1538
<210> 111
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 111
cacctgccac cacgaggcgt aggatggcct catcgtagga cctgccttct tggaagtaac 60
agcggtagat cccattctcc tgggctgtga cgttatgtat gaccagggcc acgctgcccc 120
tgttgatgtc tttgctcaca aaggtgattc ttccccggta ctcctccatc tgctcctctg 180
ttctctctct cccaccctta tacacaaaca ctgcggggga gaactgagac cggaaccacc 240
gcacctccat gtcctcagca tttttctcgg gtgacagatg gcagcgtaat gtagtgtttt 300
ctcccaccat ggccaggatg ggattagctg gccccacgac agtaaactgg gctgttcaac 360
aagggcagaa tcagacaagg atgccagtta tcacaactct aaggcaaaac aaaaaacaaa 420
aaacaaaaac aaacaaacaa aaaaaactcc agggatgaaa ggaagcagat attccaaggc 480
tacaggggtt cttgggctga saacccttct ggggaccagt agctgtggct ggtcggcagc 540
accaacccct gggagcagta actattgagg ctgctcctgc ttcacgaagg aaacattggg 600
gagcccgccc tgggcaccct gtgcccctga gattttcctc cattttgcaa tctagcactg 660
tgcctgagtg tagtgtaaac ttgaactgtc cattagggta tctatccact agctatttaa 720
cagttccaat aaaaatgaac tctaagtgta aaacacacac agattataaa gatttaaaat 780
ttcaaaatgt caaatatctc attggtaata gttctattaa ctaagcattt aaatattgat 840
atgtgattat ttatatgaaa caaaatacat tattaaaatt tatttcaagt atgtttttac 900
cttttaaaat aaaaagtaga ataggcacag ggtcttgcgc ctgtaattgc agatatttgg 960
gaggccaaag tgggaggatc cttaacagct aggagtttga g 1001
<210> 112
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 112
tggatgttct cagctggatt aattagatct aatctaaaga ctcaatttct gtgtggtggg 60
ggttcacctc cgcttttctg gagcctctga gaaactcctg atcctgcaca cccccttgta 120
aagcctggcc atgcatcctg caccccccat gacacaggga gccaagcctg acatttttga 180
gaaggtgcca cctctgatcc atcagagctg tagaggaggg aagctggacc ctggaagaga 240
ctctaaagaa aaggagagaa aacatgtagt gagaggagaa tggagtggga aaagtacaaa 300
aatactgacc tttttcttat ctgtgtctcc ttcctttcag aatggaaaaa tggccctctt 360
caagcctggt gagtaaatca ctgcatgttc cctggaccaa caacctgagg gactatattc 420
ctttttcctt ttttcttctc caactcttgt gatttggagc agaaaagttc ccttgacttc 480
cttcgtgggt aggaagacgc rtaaagggtg gaggtgaagg gaaggagaca cacactgagt 540
aatactgcag ggagagtgag gatggaaatg ccaaggagag gaggtgatgc ctgcccaaag 600
aactttgtcc ttcccaggct tctcatgcca cctactgcct gtatctcctc aaaggattta 660
atgcttccaa gctttggcct ccacattttt agatgatgat tgcaatctgt ttttcatggg 720
ggttgaggtg aagactgaag gaataatgaa catgcttggc agaaacctag caagaaatag 780
atggtgagct caaactgggt agttggacaa ggtttccaga aagaagggtt aagggaaagc 840
aacaaggaaa agtgcagtgc ccccatggtt cccaacagtg gggagctgtc tccaccccta 900
gcctgggagg gctaaaaagg ggaggcaatt actggaaccc agagaaagag gtagcttaac 960
gagggagctt cctgagaaga gtcctcgggc cttgttagag c 1001
<210> 113
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 113
ctttaactca aatgataatt ttttttttca ttttctaaat acactcatca aagggcttga 60
aaaattctga gtttttaccc ctattgttcc acagacaaca aaccttttat aaacccctcc 120
gttactgcaa aatggaaaag agcacaattg tgtccaggtc agagagtctt cacttctcca 180
ggattctgag ctccttcctc ccaagggctc aaggcctcac gatatatgaa aatgaagaat 240
atttgagacc ctgtctctac caaaaaaagg aaagtagggt gaagtcagga caataatgaa 300
ttcataggct gctcctaaga tgtctaagtc ttgcattttc acatttatca tagcctgtcc 360
tcgcgcggga gaatgtacac ctgttttgga aggatctacc ccaccaggta acagtaagaa 420
agactaagat gaacagatat ggaagatagc tcagaggctg caatgggata aattctgggc 480
agaactcaaa cagtggtcca ygcaaccttg atcccttccc tgaactcttt ctctcttact 540
caatccaacc tcaatttatt ggctcccata agttccctgt ctacccctct tgttctagga 600
actctccatt tcaaaagtac ttccaagaat ataattcagg gacgtccaca ctctaccaga 660
tctcagcctt ttgcttcccc agggcaaacc cctgctaacc cctcttccac acagaagtcc 720
accatcttca tctccacacc atcttcactt cacttcccct ccaccttcac atatgcaagc 780
tgttgtgcat aaattacaca aattataatt ataacattat acaaactctg tatgtataat 840
tttaacacgg gcttggtaaa tagcggaatt atgtcactgt aataatgttg aagcaccatt 900
aggtcatatc tgattattac taccatatca atagtgtgtg cccccaagaa agagcagctg 960
accacaaagc tcactagtaa gccacagaag aatacagtat t 1001
<210> 114
<211> 1093
<212> DNA
<213> Homo sapiens
<400> 114
tggccttgac taagtttatg gcgacagcag gtaagtctgg agagaaagct ttacaggaca 60
tgtgggtggc ttggacatgc ttctcctagc ccaatgctgt ccaatagaac tttatcctgt 120
atctgtgttg tccaacacag taatcgctat gtacatgtgg ctattaaact cttgaggctg 180
ggcatggtgg ctcacgcctg taatcccagc acttttggag gccgaggcag gcatatccct 240
tgacctcagg agtttgagac tagcctggac aaaatgatga aaccctgtct tcacaaaaaa 300
tacaaaaaaa attatcaggc atggtggcat gcccctgtag tcccagctac ttgggaggct 360
gaggtgggag gatcgcttga gcctgggagg tcgaggcatc agtaagctgt atttgcgcca 420
ctgcactcca gtctgggaga cagaaataga ccctgcctca aaaaaaaaaa aaaaaaccac 480
ttgaaatgtg gctagtacta atgaattttt actgaatttt agtggctact ktattagaca 540
atacaactca actctaggca gtggtttctt aataggcagg tagtataacc agattatgtc 600
ttagattata gttataatat ggagaatgca ttgaacaggg acaagaccaa aaacagtaaa 660
atcagtcaaa agactctcgg aataatctag gtaggtgtgt gtaaactttg gccccccttt 720
agttatcagt ccttaattct actctgattt ttttcagtta ggatgtttat ttgattagta 780
ccataaagac caagtaacaa tgattaagca agatagaaaa ttttctttgt catataaatg 840
tgctgttgaa gggcaaacca gagacttcta gaagcccttc tccacaaagt tctccagggg 900
tctatgttct tctagctgct tttggacctc ctgaggattg ccttgttcac atgggtgaaa 960
cagaatcaca gcctgcagga aggggaaaga aaatattgtg acttagaagc ttccttttaa 1020
gcaatgacag aatgaaagtt gcatataaca ctttggctca cattctatgt taagctaaaa 1080
cttgggagat tct 1093
<210> 115
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 115
acagcagcaa tataaaacta cttagaaata aataaaacat agccatgcca aataaagcat 60
aggaaaactt ctccctcctg agacccaaaa atagactcga ataaatggaa ggacagcctt 120
tgttcttgca tagaacaatt caacattatg aagatgttcc ctcctaagat ttataaacaa 180
tgcaatctca ataaaaataa caagcttctt tatgaaacta gactaagggg tggcaaacta 240
tggcccacag gccaattctg gcctgccacc tgtttttttc aaataaaatt ttactgaaat 300
agggtcatac ttattcatta atgtattgaa aggcagaatt gagtagtcac aatagagacc 360
agatagccac caaagcctaa atacaatact ttctggccct ttaaagaaaa atctccaatg 420
cctaagctgt acagttgcta ctcaagttca ctttgaaaag accaacaagg acagccatga 480
agcaatgaaa agacagacta ygaagggtaa ctaaacccat gagacattaa aataaacttt 540
aaagcttcta atattaaaac aacagagttc caaaacacaa ttagataaag ggacaaatag 600
aaaaggaaat ccagaaataa acacatatag aaatttagta tacaataaag atgacatctc 660
aaatcaccag ggcaaaaatg gactttttaa taaatgatgg taaaacatca aggtagccac 720
atgaaaatag gtacaatttg gtctacactt cataccacac accaatataa actcccaatt 780
ggttagggtt ctaaatgtat acatggaaat gataagatac tacaagaaaa ctaaagtaaa 840
ttctacatta atcttagggt accaaaaatt ttctatctgt aagactgatc atttgactaa 900
aaataaaaac tttttttaaa gttttctttt atatatacat acatatgtgt gtgtgtgtgt 960
gtgtgtgtgt gtgtgtgtgt gtgtatatat atatatatat a 1001
<210> 116
<211> 1072
<212> DNA
<213> Homo sapiens
<400> 116
ccgagggcac caaggccgtc accaagtata ccagctccaa gtgagcctct cgctgcagta 60
acagttccgc cgtgacccac accccaaagg ctcttttcag agccgtccac gtttctcaag 120
aaagagccag ttcactgtta agtttgtctc ccattaggta ccctttggga ctcgcttcgt 180
acatataaat gtacttgtat rtgtgggttt ttttttgttt tttgttgttg tttttgaggt 240
gtagtctcac tttgttgccc accctggagt gcaatggcac gatctcggtt cactgcaatc 300
tccaccttcc gggttcaagc gattcttctg cctcagcctc tcgagtaggt gggaccacag 360
gcatgtggca ccaggccctg ctactttttg tatttttagt agatacgggg tttcaccacg 420
ttggccagac tggtatcgaa ctcctgacct taggtggtcc acttgcctcg gcctcccagt 480
gttgggatca caggtgtgag ccactgcgcc cggcccaaaa tattttaaag aggattatta 540
gcaactatga gtgaccgtgg cttagggaag acacaatccc ccgagaccat gagaaagtgg 600
ttctgaggca gtcagaatgc aactgttttg tacattttag ggaagcagaa gttataggta 660
aagtcataaa taaatatgtg gagggttagt ccaggcgtgg tggctcacgc ctgtaatccc 720
agcactctgg gagtcagagg cgggcggatc acttgagatc aggagtttga gactagcctg 780
gccaacgtgg tgaaaccccg tctgtactaa aaatacaaaa aattaaacgg gtgcagtggc 840
acgtgcctgt aacaccagct tctcgggagg ctgaggcagg agaatcgctt gaacccggga 900
ggcagaggtt gcagtgaacc gagtcgtgat cgcgccactg cactaacctg ggcaacagag 960
caagactctg tctcaaaaaa aatcaggtaa atcaaagaaa atgaactgga aaaaataatt 1020
gctcttaata tcactgtgaa tacctagtga gtgttctgta gatgtgttac ag 1072
<210> 117
<211> 2784
<212> DNA
<213> Homo sapiens
<400> 117
tgataaggta tatgacaaat aagtcctagg aattattgaa ttatttcctc tgaagaaata 60
attcaaaatt tatagtggaa aaatcatcaa agaaattaaa tgctacagta taaaatattt 120
gcttaatgca aaaatggaat ataggaggaa tggaagaacc aaaaaggcat gagacataca 180
gaaaataaaa agttaaatac cagacaaatc caaatatatc agtaataata atgttatatg 240
taaatatatt aagcaattga atcaaaaggc agagactgtc agggtggata aagaaacagt 300
attcagctat cttttgtcta gagaagacac catttacatt taaagataca agtaaattga 360
aagtaaaagg atggaaaaca tatgtcatgc aaacttcatc caaaaaaagc tgtaatgact 420
atacgagtag wcaaagtaga ctttaaaaca aataatgtta ctagggacaa ataaggacag 480
aaagggctaa tccatcagga agatatcaca attataaaca tctatgcaat taataagagc 540
accaaaatac ataacgacaa aagtgacaga aatgaagaga aaaatagaca atgcaaaaat 600
aatagttgga gtcctcagtg ccccactttc agtaatgaat agaacaacta agaaatagat 660
cagtagggaa atacaagact tgaagaatgc tataaaccaa ctagacctaa caaatattta 720
tagaatctcc attaaacagc agcagaatgt acattcttct caagagcata tggaacattc 780
tctgagatag atcctatgct aggtcataaa acaaatccaa ataaattgaa aaggatagaa 840
ataatgcaaa gtatgtttgt ctgatcacaa tggaatgaaa tcagaaatca aacacagaga 900
gaaatttaaa aatccacaaa taagtggaaa ttaaatttct aaatagccag tgggttaaag 960
aagaaatatt aagataaatt agaaaatatt tgagataaat gaaaataaag aaacgacata 1020
ccaaaactta tgggattcag gtaaattagt gtttagagga aaatttatag ctataaatgc 1080
ccatattaaa aaagaagaaa aatatcaaat gagtaaacta agtttttacc ttaagacact 1140
ggaaaaagac caaactaaac agaagcaaaa ttcaggataa cagtgaaatt aatgaagtta 1200
ataatagaaa aatgtcaaga aaatcaatga aatgaaaaac tagctcttca aaaagatcaa 1260
taaaattaac aaacctttag atagagtgac caagaaaaaa agagaactga aattattgga 1320
atccaaaatg aaagagtgaa cattactact aaccatatag aaataaaaag actgtaaagg 1380
acagctgcga aaaactgtat gccaaaacat tagataactt agatggaata gacaaatccc 1440
tgtaatgatg ctaactactg aaactgactc aagaagaaat agacaatctg actagacctg 1500
taataagtaa agagataaat tagtaataaa aaaactatat acaaataaat gtccagactt 1560
agatggcttc agtgttgaat tctaccaaac acttaaaaga attaatacca actcttcaca 1620
aactcttcca aaaaacagaa gaggaggaaa cacttctcaa ctcattctac aaggccagta 1680
ccagtatcct tataccaaaa ccaggcaaag ccatcacaag aaaagaaaac tacagaccaa 1740
tatttcttat gaatacagac ataaaaatac tcaacaaaac accagcaaga tgaatccaac 1800
aacatataaa aagaactaga tatcattacc aagtgggatt tatcccagaa gtgcaagatt 1860
gttttaaatt ctgaaaatca gttaatatga tacaccatgt caacagaata aaaaacaaaa 1920
accacatgac catctcaaaa gatctctttc atgttaaaaa gtctcaacaa actagaaata 1980
gaagggaatt tcttcaaccc taaaaatgca cctacaattg catggaaccc ttgaaaaact 2040
agaacaaagt tgaaagactc acacttcctg atttcaaaat ttactataga gcaacagtaa 2100
ttaaaacaat gttgtactgc cataagcata aacatataga tgaatggaat ctacagttga 2160
gaggccagaa ataaacccat atgtctatgg ccaactgact ttttccaaga gtctgagact 2220
attcagtagg aaaagaatag tctttccaac aaatggtgcc gggacaaatt gacagacatg 2280
tgcaaatgaa taaagtttga cacttacctc acaccatata caaaaattga ctcaatggat 2340
taaagagcta aatataagag ctaaaactat aaaacccaat atttgggaaa ccactgcctt 2400
atagaaagct tatacatttg tactacaagg caaatacatg aatgtttata gcagtattat 2460
ttagaatata aaaaatctgg aaggtatctg aatgtgtatt cacaaaaacg aacaccagag 2520
aatttaattg tgatatacct gcgcagggga atacaatacc acaacgtaaa ctgaatggtc 2580
tccaggtaca ttcaataaca tggatgaata tcacaaacca aaagttgtgc aaaagaaggc 2640
aggcaaagaa taaaaagaca gtatatatat aaagttcaaa gactggaaaa tacattttgt 2700
cttttgattc atacacatga ggtgtattag tatcaagtaa ggaaaacaga gatcacactg 2760
attattttaa caggattact agat 2784
<210> 118
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 118
gcttcgaact ccaaggctct agcggtcctt ccgcctcggc ttcccaaagc ggttctgttt 60
accggatggt gccaaacagt tccaggctct tggtgcccgg tagaaattgg acgacacaca 120
cacagatagc aaagcaaagc agcaaaagtt tagtaaacag agtattacac tctcgggggt 180
gggagagagc ggactgacct ctgcgaggtg agatcagcgt cagcttgctg tagtttgagt 240
cattttatgt gtgtgcgtgc gtgtgtgtat gttttctgtt cccagtgctg cctaatctat 300
agccagcatc tgccctttta ttgataggtt tgttgcttac tttgtcctct gtggcttgtg 360
cctctatctt ataatcttaa atatatgcat gatatgtagc ccatatgcat gaaccttaag 420
tagctgatta tcatacgggc ttttgttaag gatacttttc ctctctaata cgcatgccca 480
tctctgaaga gctgcctctt maactggttt gttccagatc ttgccggcca cgaggtcctt 540
gctcacatta tctcttttgt ttcggctgca aaaggttcac tgcttgttat ctcgcttctt 600
gttcacccgc ccatctacct tacttctgcc ctttgctttt acttattctg ccctctaact 660
ttcagctccc tttgttattc tcttgcctca cttttcttat tgtttcagct gtattgcagg 720
cgcgagctgc cgcgcctaaa tttcttgatg taccgtaaac atttcaatgt ctactttcta 780
tctcaaaaca atgtggtgta aaagccgttt agttttgctt catctccata cagcattcca 840
gtgccattgc aaaatgactc gactatcaga taaaactgaa cacagctcta cttggtgaaa 900
aagtaggtgg ctctgaaaag aacctttttg gtttggaccg aggtatgagt aatgaactgc 960
tccagccccg ctacttgccc ttggccttgt ggtggctctc a 1001
<210> 119
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 119
aatagggctg aggactctac cctcagtttt caatctagag actgtgaaac tgtagagaaa 60
cacactgtct agtagcaatc catatacttt ttctagtaag catattaaaa accgaatact 120
atactatatt ccttacagcc cagtgagttt cccagaatca taaataaaac ccaccagtac 180
ctactatgta actcccagta agaggctttg acttttgtca aagttgtgtc ccagtaaaat 240
gccttcaaga taccacaaac tggcctggcg cagtggctca cgcctgtaat cccagcactt 300
tgggaggcct aggcgggtgg attacctgag gtcgagtcag agaccagcct ggccaccaag 360
gtaaaacccc tgaaaacacg tgttagcaaa cgtaccttgt tagtatctac attaagaaaa 420
aaaaaaaaaa aaaaaacctt gaaattcagg caatgtaaac aggttaaaga ttaacaccga 480
aacatcatga gtgtactgtg kagtggtgaa gcagctgaaa acggactcgt gtcatctttt 540
tatgattgtt gaagtggctc tgaaaagagc ctttgttttt atgcgctttt caactcggtc 600
tttacttagt cttgtggtgg ctctcagttt tctttggcag cagcacggcc tggatgttgg 660
gcaggacgcc accctgtgcg atggtgactt tgcccagaag cttgttgagc tcctcatcgt 720
tgcggatggc cagctggagg tgacgcggga tgatgcgagt cttcttgttg tcgcgggccg 780
cgttgccagc cagctccagg atctcggcgg tcaggtactc cagcaccgcc gccaggtaca 840
ccggcgctcc agcaccgacc cgctccgcat agttgccttt gcggagcagg cgatgcactc 900
ggcctacggg aaactgaagc ccggcccgag aagagcgggt cttggccttg gcgcgagctt 960
tgcctccctg cttaccacgc ccagacatgg caaaaggtct a 1001
<210> 120
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 120
tcactaccaa agtatatgac tactactata gatattttat tttatttatt gattgatttg 60
tagagatggg gtttcattat gttgaccagg ctggtcttga attcctgggc tccagggatc 120
ctcccatctc aacttcccaa attgcaagga ttacaggcat gaaccactac ttaaacttgt 180
attcctttat gctttttttc atttgcaata ttgactataa tcaggaaaaa aaatatatcc 240
tttatgaaga agaaaaactt atgtctcatt ctaaggacag cagagaaatt gttaactcag 300
ggaaaatgat aataaaaatg ataccccctc tatagcaaca taaagagcag tttcgaggag 360
caaaagatgt ggtgaaatgc attgtttact ctgggtgggt gcaagatcca ggcaggggtg 420
aagcatggcc ggctgcacag atctctgttc tcttgtttcc tttacatccc tccccacctc 480
cctctgcaga tcttgttctc rgaggccatt cccagaccca cagcaagagg gattatggct 540
gcaggcctca tgctcctttg ttttggaaga aactgttgag gagttagtat ttactgagca 600
gctaatatgt tcccgtcact attgtaactc ataataatta ttgttaagta atacacgaaa 660
agttttaaat ttaaagcatt ccaatatttt aaaagtaaag ggaacaaaag gccaagtgtc 720
ccttcactca ctaacctctg atcttcagat tagcatgcgt cttttttgag tttttcaggc 780
atttacataa atagttatgc agaaatggat agctttgctt ctgttcttca attgaatctt 840
tagtatagtt gtgcaaggtg ttttttgatc acttagtgtg tctccgttat ctaggttcat 900
gacaacaaat caactctttt tacctgctgc attgaattcc ctccgaggga tgagccgtca 960
ttcctctaag cagtctcctg atgggtggct ggttcagttg g 1001
<210> 121
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 121
ggggatggtg tagactgtgc caagttgaag acccatgtag ggaagaggcc aggagggtcc 60
ctagtaagcc tgacataagg gtgtaccaat aggtggccag aaatgccttt ctgctcttaa 120
gagaacacta atactttgtg tatagcctgc cgtgggaggg atttcaggtg ggtgggagag 180
cacagaaccc aattgcccac tcccagtgag cacttttcat cttatgattc agcccctctg 240
cccataagca ccacagaatc caagctttac cagataccat ggcacatgga cctttcctct 300
ttaggtgaat ttcaaaattg ccactgtcaa cttgggacaa aatagcaaat tgtcacagcc 360
agacatatta acttggggaa tggaggaaat cattttaaca caatagaaaa gtagactgaa 420
taagtaagaa taaatacaga tgggagaggt ctgcagaatg cccggagtct ggagcatttc 480
ttgtacctac agaagtgata ygtgaagaca tcagacccat gttgttgaag caaaactgga 540
tgggaatagt tactccctac atttgcccac agacccctca ggcaacaggt tttcttttgg 600
ggacatttat tctccttctt cattttttga agggtgccct tgttagtcat ttaagtcagt 660
tgtgatctgg taaaaggaac acataggacc aatgaagaga ccctttatcc tccaggacag 720
tgtgaaggga aagactcacc ttagttgatc caccggggag aggaggagca ggacataaag 780
cctttgtgct ggtttaagcc aagttggaaa gtttctaagt aaagaaaatc ccagagatca 840
taggtcttca tttggggttt tgttttgttt tgttttgaga tgatgtcttg ctctgtcacc 900
caggctggag tgccatggca caatctgggc tcactgcaac ctctgcctcc cgggttcaag 960
caattctcgt gcctcagcct cctgagtagc tgggattaca g 1001
<210> 122
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 122
aaagacattc ctagaagtca tccttcagtg atatcaccac ttgctcagtc accatctcaa 60
ccttatgtca cctcagccct catctcaatg cccaaacccc ttacacacac cttcagttag 120
cttcaactgc ctccgtttcc acactgtgca cctttcactt tccctaccca gctttcctac 180
atgctgcctc tcctcagggt cccctgaatg ctgcatcatt gtgttcagtg cagctggact 240
gattgcacct gtgtatttgc ccctgagcac tttcctttac acatgtggct tgtcttgcca 300
atagactcca ggcttatacc ttccatttcc atcgtattct ccagtttcca ggatagacgt 360
tgctcatcgt ctttacctaa taaataagtt tgtctgattg ctgaaagcaa cctcttaacc 420
tttctttttt aatatcaact gaaacaaaat aaaacatagg gcaagaaacc tgcatgggaa 480
tgcagctgtc taaagctttg hcattgtatg tggtctaaga cccatcccta ggcctgatgg 540
cagtgggctc accagggcag gtgcacatgg gggctgatgc ctcatgaggg aacaactgct 600
taccagggtc ttcaagcagg aatacagaat ctcaactcag gaacaatttt ttattagtcc 660
atcctcatat ttctgtaaag aaatacctga gactgggtaa tttataaaga taagaagttt 720
aggccgggca cggtggctca tgcctgtaat cccagcactt tggaaggccg aggcgggtgg 780
atcacgaggt caggagtttg aaaccagcct gacaaacatg gtgaaacccc gtctctacta 840
aaaacacaaa aattagccgg gtgtggtggc aggcacccgt aatcccagct gctcagaagg 900
ctgaggcagg agaatcactt gaacccggga ggcagaggtt gcagtgagct gagatcgcgc 960
cactgcactc cagcctgggt gacagagcaa gactccattt a 1001
<210> 123
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 123
cattatggtc tcgaactcct gacctcaggt gatccgtccg cctcggcctc ccaaagagct 60
gggattacag gcgtgagccg ccgcccaacc acttttttta gtattttaaa tcaagtatct 120
ttttgtttgt ttgtttcttc tgtgcctatg cttacccaga cagtttcttc atttattttc 180
ccccgccttg ggcaggcttc cactcttcag accctttcct gcacaacttt gtccctgagc 240
ataggtcctg gacgtaaaag aagggacatc gtctggagaa atattgaatt aagaaaggcg 300
cggctgtgaa gaatagaaat cagtgtctcc cttagtctct cagttcggcg atcttggtaa 360
tgccctgtcc catgcctgct aacgcgattc agcctcgata tccccgtcca gtcccacgat 420
cgcaccaaga agagcttgcg agccttcctg ctacatactg acattaagaa accggacttg 480
aaagggatcc cagacaaacg wtaaacatgc aacaagaggg atagggtgta aggaagagaa 540
tccttggggc ggtgtctgat aaaacagatg gctctccttt ccaggtgttt ctgaatttga 600
tccccgacgc ctggggcatc gtggaggaac ttgcatagga aatcaaggtg tcgcaggaaa 660
gagaacacgc acaagcaaaa gataccttaa tttgtagtat actcaatatt tatcgtacag 720
aagtgtatcg acgatagaca atgtgcgatg tgatgggtgc tgggaactta acgaactctc 780
cacgcgccta gacctcattg gatccacttt ctcttgggct gtgagccggt aaaaaaaaaa 840
ggggtggatg tggaggacgg tccaaaggat tcggagctcc ttaaaatgct actcaaactt 900
tatttagcgc gctggagaat ccctgagaag gagtattata cccagttttc cgggacttac 960
ctccagtgat tctacgtcga ttctttgatg aggcccatta a 1001
<210> 124
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 124
gaaaaatttg aacaggcgct tcacaaagac ggccaaatgg caactgaaca atttgcaatc 60
agaaaaaaaa aaagaaagaa agaaagaggg aagagggtct aaacaagcaa ataaacgaaa 120
aacgagaggc gaggctacca ggtttcttcc atttctggca aacatttatt gttgttgttt 180
tttccttcac agaattattt tcagaaacct tccacaggag attcgtgcgt ggagggggtg 240
gggtggaaag aagtagggaa tggagaagat tactaagaaa agtttcctgt ctggaactgc 300
ggcagatctc tttggataga gatgactact taacctcact ctgctttcct tcgccgcggt 360
tgcggccgcg accctgttct taccaccagc aattcctcca gggacttggt cagcagccca 420
acttgatctg cgtctctctg ctaaggtgtt tccgcaacag ggtcaactcc aagtctcacc 480
tttctaggaa tcccgggcgc mgcgcggggg tcgggactcc gacctgtatt tccaggcgga 540
ggtttccctg ggtcaggcgg ccactctctg ccagagattg tcagttatcc aactgtcaat 600
agagccgccg ctccagcgag tttaatttag gcacagaaaa gtcctgcctg ggttgaggtg 660
ggcttaggat gagtttactt gagtgtgtga tttagaaata gatctatggg acagacagac 720
acgaaatcgg gcattggggc cctcgcaggc agggtatcta gactggcagc tgccggtgca 780
ggatattgcc aaggactcgg catccggctc agctcaaggt ggggacgaag acgtcctggt 840
tgcaaggagg agccctactc cccccggaat cagaactgtg catagcgggc tctggatttg 900
ccgggatgtt tgaggaattt gaaatgagaa aggagaggag gaaatggttt aatggtatat 960
tgagttactg gagtgtattt tagtcaccga ttttggtttt a 1001
<210> 125
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 125
tttgatcctc ttaccggcca catgaggaga attagttctt taccactttt gttgatcaca 60
tctcctgtga attctgcttc cagtttctcc gaaagtaagc tctatatcgc cactactgaa 120
ctggaaacac agtctttcaa aagaagaaat gtgggcgagg gcggtggctc acgcccgtaa 180
tcccagccct ttgggagacc gaggtgggcg gatcacttca gttcaggagt tcgagaccag 240
cctagctaac atggtaaaat ctccgtctct actagaaata caaaaattag ccgggcgtgg 300
ttgcgagcgc ctgtaatccc agctactcgg gaggctgaga caggagaatc gcttgaaccc 360
gcggggggga gtgggggggg ggcggcgcgc agaggttgca gaaagccaac atcgtgccac 420
tgcactccag cctagctgat aagagcgaaa aaaaaaaaaa aaaaaaaaaa gaagaggtaa 480
catgtgagag ctaagacgga rgccttcatt tttgttttta agtaaaattg agtaaggtaa 540
ggcgtgtgtg ctaagggaag gggaactagc gttaaacaat ttccagtttt gttttagaca 600
aaactttctg aaacatcgtt tcacattaaa cttgtgaaag acaaaaaaag attctatttg 660
ctgtggctgg ttagctcaac tggttagaat tcggtcatag attcccgttt gtccctgcct 720
aagaacactt tgtggtctcg caagtcctct ccaagattta acaacgtccc caataaatct 780
gtagaatccg atggctgttc cctcacagtt taggtctttg cttttatttc catcttcata 840
catagaaaat tggcctatgt gaattgtctc catctgagaa gaaattgtaa agccatctgc 900
acttccaatc acttccacac ttgggttttc accggatcac atgaaatagg atttttaaat 960
gacatatgtg aacaattttc attaacatca acacactagg a 1001
<210> 126
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 126
ggtgcaagca tgcatgtcct gttgcttcgc tgcgcgaggc tgaggcacga gttgctggat 60
tttgggggtg gggagtgcgg tgcttggctc ctggctggtg aatcagtctg tgaggatgct 120
ggggtgggcg ggcggagggg atatggggag agtgggtagc gcagtgtgtc tggtggttct 180
ttagttctcg gattgttact atttgtgttc ttatcccggc tctgttcacc tctctttccg 240
gacctgttta ctggtttgtt acatgaatac aacctgagta aaagtctcgt cagcttttct 300
acaaaactga acataactct ttagcattgc tgcctaggtc aagaaactat ttgatcaacc 360
gcccctcttc tttccaccct caattttaca ttgaggctga ggacttgtgc cggttttaag 420
cagcgttcag ggctggccag attaaggagt ggacaattaa ggaaagaatt gagttagcta 480
gaggaaaggg tgcgatttac rgttcccttc ctcctgggca aaaactcttc aggtgggact 540
cccactggca gatgtgaaga acgttgcggg cagtgggagg tgcttttgag tgagtgctgc 600
ataggcgtcc tggacgggtc tttgtctttg gcgcgcagac cggttcgtga gacgcaagaa 660
gaaggcagca gcagctgccg gaggaaaaaa gcggtcctac accaaggact acaccgaggg 720
atgggtggag ttccgtgaca agcgcatagc caagcgcgtg gcggccagtc tacacaacac 780
gcctatgggt gcccgcaggc gcagcccctt ccgttatgat ctttggaacc tcaaggtgag 840
aagatagatc tttctgccac acctctcacc ctcccttctc cccaactctg gcccaagtat 900
ccccatggcc tctcattggc cttgtcccct tgtctcatct ttctccctaa tctgcactat 960
cctgatcttt tcttcttttc tgcccacagt acttgcaccg t 1001
<210> 127
<211> 1399
<212> DNA
<213> Homo sapiens
<400> 127
tccctcatga tctgtttcct ctgatttcaa caagcaggtg ttctttctcc tgtctcaggc 60
taattctgca cccacatcgg ggagccccca ccccagcttc cctcaggctt ctctatttgg 120
tcaattcatt aattcattca tttgacaagg atccatgaac gctaactatg tgccagtcac 180
tattctaggt ggtggagtca yagaagtgaa caaaacagaa agttctcatt caaaaacaac 240
ataacttgtg gtaggaggca gacaggaaat gaaataatta gtaatatata tggtgtgctg 300
gatgatgata agtgctcagg agagaaataa acctggaata gcagaacttg catttctttt 360
tgaaggggtc ttgctctgtt gttcaggcta gagtacattg gagtgatcat agctcactgc 420
agcctaattt tttttttttt tgaaagacag agatcttgct atgcatactg cccaggttct 480
tgaactcctg gcctcatgca attctcctcc ctcgatcttt caaggtcctg tgattacacc 540
tgtaagccct cgttcccggt tggaagttac agtttaaaat agggtggtta tgagcaaggg 600
gagcgaggca cagaatactt gggagaaaag cattccgagt tgagagaaca gcagtgccag 660
agcacagagg cagaagcact gtggtttgtg tgaagaaaag caatgaggct ggggtgcgca 720
gagcacacag ggtgatcagg agaagaggag gtgacaaggc cagagggggt tgagggccag 780
atcatgtatg gccttgaaag tcatcatgct gacctgggct ttacctctga gaggggagcc 840
actggaaggt tagagcagaa aaaggactgg actgacttat gttttaagaa gttacttcac 900
atgctagacc aagatgggct gtgggtaggg gtggtggatg gaggcctgaa gacccagctg 960
ggagctactg cagtgatcca ggggaaagat gcagatgact tgtaccaggg aggagccatg 1020
aaaatgttat gatgctggat ttattttcaa gatagaataa aaaggctttg ctgataaact 1080
tacaggtggg gtgtgaaaaa ggagggcatc aagggtgacc acaaggtttt ggtcctaaga 1140
aacggtacag atggagttgc cacttactga gatggggaaa atgagggaga aaccgcttgt 1200
ggaggccaga ggaggagcca gcacagaatc caaaggtcag ttttgaatat gttgggtttg 1260
aggagcttac tagagattcc cgtggagatg tagagtaggc aggtcaataa taagcttgca 1320
gtccaggcaa cgggtcaggg ctggaaacac aagttattct ctttgtcttc tttatattca 1380
tgtttgttgc cactgtgtg 1399
<210> 128
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 128
tgagaaacag cttaatggtg tcttgtgata aaattgttaa attttcacga agtcaaattt 60
atttcaattt tgtttactta tttttgtatc tccctatgaa atctttgttt ccccaaggtc 120
atggaaatag cctatgctcc acgacccccc cccccactta cataatcatt taccttttat 180
ttatttattt ttattttatt tatttttttg agccatcttg gctcaccaca acctccatct 240
cccaggttca aacaattctc ctacctcagc ctcccgagta gctgggatta caggctcccg 300
ccacaacacc ccgctaattt tgtattttta ttagagaccg ggttactcca tgttggtcag 360
gctggtctcg aactcccgac ctcaggtgat ccccctgcct cggcctccca aaaccctggg 420
attacaggcg tgagccactg tgcctggcca catcatttac cttttatttt taggaatatg 480
atcaaaagac ctgaacaggc rcttccaaaa tagaatatgt caatggccag taagcacata 540
agcagatgtt gtgatatcaa taaaaagttt gcttatttat tttaaccagt ggtgaccaga 600
caaaagacct caactgtctc tggaaacttt attttatttc cagaaatctt ttcaaaactc 660
ttctgtgaag gttgtgtttg tctgggggag gggtgaagtt gtggtttggg atgagttgca 720
gatgaaggag ataagacaag gtttctgcct tcaggatctt caggaatatg tgtcctttaa 780
tcagactgct taacttgatt tggctgatcc ccctttcttt ttcagttccc tccatccctc 840
taatccccat cacctaaaaa gacctccaga gacttagttc atagctgggc ttgatctata 900
tctctttgct ccagacattt ctgctctgtg tcaatgccag cctgcatcta tctgggatgt 960
tgggtggggt agtagagtgg gatcggtctc tctagccata a 1001
<210> 129
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 129
aagaagctcc tgaaattttt atgttagttt tgtcttttta ttttcctcct tcttcttctt 60
cctctttttc ttcttcctct tcttcttctt cacaccacta tacaaaggag gaagtttagt 120
tttgtctttt actttaaatt acacaagatt tttttttctt tctctctctg tctctttatt 180
attttaaatt gtttgtagag atggagtctc gctcgaactc cttagttggc tcaagtgatc 240
ttcctgcatt ggcctcccaa agtgctggga ttacaggtgt gagccaccgt acccagctga 300
ttttctcttt aacctggcaa tgactcttgt ttctgtttta ttatagaatg gaaactggct 360
cgatcttgtg caggttagtg gctgggcact gctctgggtg ctgagattta acctctgagg 420
tatccaaaga cctaaaataa gtggaaatga aaaatgctga taccctttta gtgatgaaca 480
cagagatttt aagttgtggg raaaaaaaaa agaaagaaag cctaatactt ccttggaaca 540
cagagagggg ctttggaaga tggccaagag tccagcttcc tgtgagatta tctcacgagg 600
cattacaagc ctgggcacag tcaactctta acatcaccct ctggctgctg gtgacagagg 660
gagcctgggg gaatggagac cccttagcag gccaaacagc cctccccctg aggagaccta 720
tcaactccta cagcagtgct ctgtttctta gaagcaaaaa tagtcctgta accataacac 780
tcaccaatgg tcagactttt tgtttctgtc tttctctcca gttgaagtga ctctggaccc 840
aaacatagcc ctccctcacc tctttcttta ttaggattca aatctgtttg actggaagat 900
tcatgtcaga aactgcctga aaaaccagag agatgtgact cctggccctg tgtgctaggc 960
ctggaagcct tcacctcgga gagacattac caggaagtgg a 1001
<210> 130
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 130
cacccttcta tgcatcctca agcctaatct ttcctggtta tgtgacaaga acccggtttt 60
tagctgaact aaggagaaag tcctacaaca ctgccaccat gtggcaatta ctccaaatag 120
aaggagaggc tgaaggacac acaaccagga tgcagagaaa aagatggaga cagagtctgt 180
gcaagatggg attgatactg agactgggtt agccacctct cctagacagt gaaacagatc 240
gcaagagagg ctgacccaga aagacacatg caaaacaatg ggcaatagaa cacatgacct 300
gaattagatt atctgggttc aaatcctgat tttgctattc attatctgtg tatcactggg 360
caatttactc aatctctctg tgcctgaata tcctcattca aaatcaggga tgaaaagagt 420
acttatctca aagggctatt tgctcactta ttgcacaagt aatttggcat ctgatatgaa 480
ccaggtgcac ctctagatga rgatactgtc acattgaatg aagaccagtg accagaagcc 540
tgcctcacag cccagctcag tgagaaaaat aattccattc tcacctctaa tctcaaccct 600
gtgtcaccat ttatgtatag tcctttgcat tagtgtctgg aaaggtcatt ttttgagggc 660
agaatgaata acctatagaa ggatcattct tgggtataat gaattaaaga agtattatga 720
agctttataa ggcaggatta gctcataaaa atggagggtt cttttgcttt tccagtccca 780
tttgttgttt cacagacaaa gaataaaaca atcactgatg gcaaagactg caaactgcca 840
acgttcatcg gtagagcaag gtgacgctcg tcctgtccag gcctgtggtt gggataagct 900
cagaaagcag agtctccagg gctggtcatc atctatcata accctgcgta taaagaaagc 960
cttgagaaag aaaagaagtg acttattatg tgtcttctga c 1001
<210> 131
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 131
ctgtggacac tgctgaggaa gcactgttaa acgcccttct tcccactgcc atcatatcta 60
agtcagcgtc tcctaaagag cccgaacagc tgctgaagct tttcattgtc attggagggt 120
tgaattttgt ttttttcggt tttgtttttg ttttttttga gacgagtctc tttctgtcgc 180
caagctggag gagtgcagtg gcgcaatctg ggatcgctgc aacctccgcc tcctgagttc 240
aagtgattct cctgcctcag cctcccaagt agctgggact acaggcgggc accaccacgc 300
ctggctaagt gtgtgtgtgt gtgtgtgtgt gtctgtgtgt gtgtagtaca gacgtggttt 360
cactatgttg tccaggttgg cctcccagag tgctaggatt acaggcatga gccactgcac 420
ctggccagga gggttgagct ttgaaacaac tgatgagagc ctgaggagcc attttgagca 480
atagggaacg ctcacggact rtgtagtaaa gaaagatcca aacaccaagc actccagggg 540
ctttgggttt gtcacatatg ccggtatgga aaaggtggat acagccatga atgcaaggcc 600
gcacaaggtg gatggaagat ttgtggaacc aaagacagct gtttcaagag aagattctca 660
aagaccaggt gcccacttaa ctgtgataaa gatgttaaag aagaactgaa gaacataaac 720
taagagatta tattgaacag tatggaaaaa ttgaagtgat tgagatcatg actgaccgag 780
gcagtggcaa gaacaggggc tttgccttgt aacttttgat gaccatgact ccatggaaag 840
gattgtcatt cagaaatacc acactgtgaa tggccacaac tgtgacttta ggagtgctct 900
gtcaaagcaa aagatgttta gtgcttcatc cagccaaaga gatcgaagtg gttctggaaa 960
ctttggtggt ggcgttggag gtggttttgg tgagaatgac a 1001
<210> 132
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 132
ctaccttgac agctataaaa agtcgctcta aagaaaaaga accagctctg gccaggcgca 60
gtggctcaca cctgtaattc cagcactttg ggacaccaag gcaggtggat cacttgaggt 120
caggagtttg agaccaagcc tggccaacat ggtgaaaccc tgtctctact aaaaatacaa 180
aaattagtgg agtgtggtgg tgctcgccta tagtcccagc tctcaggagg ctgaggcaga 240
attgcttgaa tcagggaggc ggaggttgtg gtgagtcaag attgcaccac tgcactccag 300
cctgggtgac agagtgagaa agaaaagaaa agaaggaaag aaaagacagg aaaaccagtt 360
atttccactg ttttcacaga acaaatcaac agactgaagt ttactcgtgt caacagtgtg 420
tgaggttaca atgtgatact tactattctt gagatggaaa tgttcagaaa agaagccaca 480
taaagcacat ggtggaagag maaaaatgca aaacaggctt aaagaactgt gagagtttag 540
aaaaaagcaa tagatcaaag ggatcaagaa tgggcattag aagatgaaac tgaagacaga 600
atagggagta gggggttcca ggcatggaaa taggatattc tgtatgagga aaagagaaga 660
acctctttag ttgggcatga aacatacatt ctaagtagaa ataatttttt ttttcttgag 720
atgacatcta gctctgtcac ccaggctgga gtgcaatggc acaatcttgg ttcactgcaa 780
cctccgcctc ccaggttcaa gcgattctcc tgcctcagcc tccaagtagc tgggattaca 840
ggtgcccgcc accacgccct gctaattttt gtatttttag tagagacggg gtttcactgt 900
gttggccagg ctggtctcta actcctgacc tcgtgatccg cctgccttgg cctcccaaag 960
tgctgggatt accggcatga gccaccgtgc ctggcccggt a 1001
<210> 133
<211> 2091
<212> DNA
<213> Homo sapiens
<400> 133
gtaagtacca ttaacagctt ctcttgaact ggtttctcta aaaattcctc ctttaccttt 60
cttctaaagt gtcggatcct ttacctttca aaaacgagga ataggtctcg tggctcatgc 120
ctagcgagac ctcatctcca caaaaaataa taataaaaaa attagccagg tgtggtggtg 180
tgggcctgta gtcctagtta ctggggaggc tgaggtagga ggatcactta agcccaggag 240
gtcaaggtta tagtgagtta tgatcgtgcc actgcactgc agcctaggtg acagagcaag 300
accctgttcc ccaccctctg caaaaacaaa caaacaaaaa agcatcctga taaacataga 360
catgaaattg aaacatacag gtgaagggtc acagatttat gcctcagtct tctcatctgt 420
aagacaaaga cagcctcatc acttttaatg aggtgagyga atgagggagg agaccacccc 480
tcatattgtc ttatgcccga tttctgcctc caaagaaaga agaagtaaaa actaaaaagc 540
agaaatgaaa tccacaggca gacagcccgg cgccacgccc tgggcctggt agttaaagat 600
taacccctga cctaacactg gttatgttat ctatagtttc cagacattgt atggaaaagc 660
attgtaaaaa tccctgtcct gttctgttcc gttctgatta ctggtgcatg cagcccccaa 720
acatgcaccc cctgcttgct cagttgatca cgaccctctc atgtggaccc ccttagagtt 780
gtgagccctt aaaagggaca ggaattgctc actcagggag ctcggttctt gagacagaag 840
tcttgccgat gctccaggcc aaataaaccc cttccttctt taactcggtg tctgaggggt 900
tttgtctgcg gctcttcctg ctgcacatta agtgaggtac accactgcat attacatggc 960
aggtgctcag tctcctcctt ccacttcctc actggttttc tagtgaagag agaatgaagg 1020
ggtgggttgc ccctccacac ctgtgggtgt ttctcgtaag gtggaacgag agacttggaa 1080
aagaaaaaga cacagagaca aagtatagag aaagaaataa ggggacccgg gggaccagcg 1140
ttcagcatat ggaggatccc accagcctct gagttccctt agtatttatt gatcattcgt 1200
gggtgtttct ccgagagggg gatgtgtcag ggtcacaaga caattgtggg gagagggtca 1260
gcagacaaac acgtgaacaa aggtctttgc atcatagaca aggtaaagga ttaagtgctg 1320
tgcttttaga tatgcataca cataaacatc tcaatgcttt acaaagcagt attgctgccc 1380
gcatgtccca cctccagccc taacgcggtt tttccctatc tcagtagatg gaacgtacaa 1440
tcgggtttta taccgagaca ttccattgcc cagggacgga caggagacag atgccttgct 1500
cttgtctcaa ctgcaagagg catgccttcc tcttatacta atcctcctca gcacagaccc 1560
tttacaggtg tcgggctggg ggacggtcag gtctttccct tcccaagagg ccatatttca 1620
gactatcaca tggggagaaa ccttggacaa tacctggctt tcctaggcag aggtccctgc 1680
ggccttctgc agtgtttgtg tccctgggta cttgagatta gggagtggtg atgacgctta 1740
acgagcatgc tgccttcaag catctgttta acaaagcaca tcttgcaccg cccttaatcc 1800
atttaaccct gagtttgaca cagcacatgt ttcagagagc acggggttgg gagtaagttc 1860
atagattaac agaatctcaa ggcagaagaa tttgtcttag tacagaacaa aatggagtct 1920
cctatgtcta cttctttcta cacagacaca gtaacaatct gatctctctt gcttttcccc 1980
acagagaagg cccatgcaac acagacctaa acccctttga gaggaaaata gggcatttgg 2040
tggaggggag gggaggagtc ctggcttgcg gctataaaaa tgtttttcca c 2091
<210> 134
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 134
cctctttccc tgttttatta ttatttttct ccaatcgctt atcactatta ttttgtttat 60
ttaatgcttt attatccgct tccgccactg ccatgtaatc ttgagggcaa gggtctctca 120
tgttttcttc accgttatct gcagtgcctt gaacactaat actggttgaa tgaacgaacg 180
cattaatgga gcggtgatat tggggcagag aggatgcagg gcttgctttt caccgccatt 240
tttcagccgg cagagacaga ccgagaaagg aatgaaggcc acggggcgtg tgcagaagta 300
gctaccagag agtccatgcg ctgcgagcct ggaccagcgg gcaaacgcgg cttacaggcg 360
ttcacccaga tattacgggt acaacctagt ttcttatgaa atacctcgcc cctaaggtac 420
gcgcagggcc agtggcgcaa tggataacgc gtctgactac ggatcagaag attccaggtt 480
cgactcctgg ctggctcggt rtaagcaggg tcgttttaca actttctgac tccgcaggag 540
taaggaaatt cctgcaagat aaatttgcct ggaagactca gaagcaagag gggcagctcc 600
cgacaacata tggggttatc atttctttgc ggagcattct gccactgacc acgtggtaac 660
gccaactacg ccagagaaac gctcgcccta cccaagttgt gcccagcctt gcctggccat 720
tttggccgaa gaacgaagga ccgttcagag attaaattaa agtctctatt gtgttcttcc 780
ctattcagtc atttgtagaa taaattctat ggcttcagtt tgaacactgg aggggctggg 840
tctgagcttt tcattggttt ttctggtttg agaggtcggt acagagacgc acgcgcacat 900
cagcaaaaca cgcacttgga acgaagaaac acggaactag gcaggaagaa ctatttactc 960
tgaaaaataa gcccttagtg ggtttccgta gtgtagtggt t 1001
<210> 135
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 135
cgcggggaga ccccaatgga tttcaagtcc atcgccttaa ccactcggcc acgactacgt 60
acctccttca acaacctgga tatattccca tgaggaatat atgtttcttt tcacagacat 120
ctttaaattt gtttattttg acaaggtaac aactctggaa tgtctctcat cctggttaaa 180
aaacaaaatc aaaattttaa agatttagat attggctaaa agagatattg caaattgcaa 240
gacttgtctg atgtaggaag tacgaaagac tttacgaggg ggccacacgc caacccctaa 300
atggtctcca aacctacgaa actggctgaa agctctccac acctaattag taggattaca 360
gatattgaag cctacaaatg cgcatttcca ccaggatacc ttgtggattc ttacacgggt 420
caggtccgct gacgtttagc acgcctactt taaaacctct tttctgtagg gtcctagtct 480
tcaagtaaaa tatatgcggc yatatagcag aggatggttt cgatccatcg acctctgggt 540
tatgggccca gcacgcttcc gctgcgccac tctgctgtct cgacagtccg ctccgccact 600
ctgctgtttc aacattactc ttgtcaagta tgtattagag gctacaattt tcggcatctt 660
cctaatttta aatgatttgt tgtcgtttgc caaattatcc tggagaatga gaagtgcaca 720
ctggccatcc atatggggct gcacgccact tccaaacacc agcggtttag aattcttcct 780
cgataaattc gaatcagctg aggttgaagt tctctaaaac ggaagcatgt ttcgagttat 840
gggaaaacaa agtgcaggct aattggcata atttataaag gtgaaattat aaatgcttgg 900
gcaaatttca gccattcctg gataccggag ggagtcgtta ttacttccaa acatttttta 960
cttgagattt tcatcgaaaa tgttcacagg aaaaaaaaaa t 1001
<210> 136
<211> 1256
<212> DNA
<213> Homo sapiens
<400> 136
ctgttaggct ttctccaaca gcagaaggct ctgtgatctc catctcttgg gaggcagaaa 60
attaccacaa gaaaatagcc gggaggcagc ggattgaacc ctggaaacgg cccgctcttt 120
gtgctgggcg gtgctcgaag ggaagaaact gagggcccgg gagtcgagtg tgtccagttg 180
tctgccaggc aggataagga ctgggaaaaa tgaaaaaaaa attcctagac atacacaacc 240
taccaagcct gaatcatgaa gacacagaaa atatgaacat accaatagta gataaggaaa 300
ttgaatcagc aataaaaaca tctcccatca aagaaaagcc caggacctgt agcgtctcta 360
gtgaattcta ccaactattt aaagaactaa taacatttat tatggaaaac agtattgtgg 420
ttcctcaaaa aattaaaaat agagatacca tatgatccag caaactctct agtgggtata 480
tagctaaagg aagtgaaatc agtatgtcca agagattatc tgcataccac caagatatgg 540
aattcttctt yttttttttt tttggtggca cagaatctct ctctgtcgcc cagggtgcga 600
ttttgactca ctgcaacctc tgtctcccgg gctcaaacga ttcttgtgcc tcagtctccc 660
gagtagctgg gattacaagc ctatgccaat ataccccgct gatttttttt tttttttgta 720
tttttagtag gggcgcgttt tcaccatgtt gcccaggctg gtcttgaact tctgggctct 780
cctcggcctc ccaaagtgct gggattgcag gcgtgagcaa cggcgcccag ccaagatatg 840
gaattcttgt gttcaccaat ggatgaatgg atagagaaat gcgtttagct tccctgtgcc 900
ttggaagtat catttccaat ttatcatggg tgtgtacatt tttattggtg tacttgtgag 960
ctcatcacta atttttgcag tctgttaatc taccatagtt tcagtttcat tgtattttct 1020
tatatattta tattgtgtac tgatgtgtgc atggattagt aatgagtact ctattatttt 1080
taatgtcata attattcatt atttatttat tatttattaa aaataatatt taatattaaa 1140
tattatttat tacttatatt atttattatt ataataattt ataatatgtc acattataaa 1200
atattattta attaaaattt aatgtcactc tattatttta atatcataaa atacat 1256
<210> 137
<211> 7021
<212> DNA
<213> Homo sapiens
<400> 137
ctaatagagt cctccctctg atcagtggca aagagtagcc attatcattt tttaatggta 60
ataatattta ttacttttta aacttatttt ttaatggtaa taacatttat attatactgg 120
gtgtctgtat attgagttgc cattccaaag gactatataa aaaatatata tctaaatgct 180
tgacaaaaaa aaaatgcaat ttttttggaa aggaatatat ttggtggctg cctcatgcag 240
cttaagtgtc caaaatctga tagattggtg tatcccagtg gtagttttct gttgccacaa 300
actccaatca gcaggaatgg gggttgtaac tcctgtacaa tagttctacc ttatccacag 360
ttctgttttc tgcagtttga gttgctcctg gtcaaccttg gtctgaaaat attaaatgaa 420
aaacttcaga aataaacatt tcatatgttt taagttgcaa ctgactctgg gtaggataat 480
gaaataccac cctgtccagg atatgaatca tccctttgtc ctgcttatcc aagctgtgta 540
tgctaactgc ccattagtca ttgacatcat ctgcccctga catccaacca cagacgttat 600
catggctcag tgatccagga tcacccaggc agatgatcct ccttctgatg tatcatgagg 660
tcaacagtag cctaacgttc catcacagtg cctacttcac tcatctcgct tcatctcacc 720
acttaggcat tttatcacct catcatcata agaagaaggg ggagtacagc acaagacgat 780
attttgagag agagacccca ttcacataac ttttattaca gtgtattgtt ataattgttc 840
tattttaagc tagtgttgtt aatctcttac tatgcttaat ttataaattc aactttacca 900
taggtatgtc tgtgataaac attgtatata tagtgtttga cacatccata gtttcaggca 960
tccactgagg gtcttggaac atgtccccca aggataagtg gggactactc tagtgccatc 1020
aggctagcag gctgtaaagg ttttaatggc agtccctgga ccatggctta tttaattgct 1080
tccaaggccc actgctacaa agggcctcat tcaaagctgg tggctttgtt ggtcaccctg 1140
acttagggga ccaaaagaac actcaggtgg ggtacatgtt gcctccaatg cccaagtacc 1200
caaagaggcc ttccagctgt tgggcctcct ttttattagt ggatgtctcc aaaattaaat 1260
ttttttgctt ggttgtatct agaatacttt tctggcttac tgcccatgtg gccttcgcat 1320
ttagcccagg gacagtccac tgttagtctc cacatccgaa agcctttttg actagccaaa 1380
ctgagctgtt acattatgac agggtagttt gtagcatttc catttgtaac aataattaac 1440
acaataatgt cctgttcttc agttagtatg cagtactgtt tttttgaata acccactggg 1500
acttgggtgg cttaggtggc agacaggcat ggatatgccc cgccgtaacg gctggaattc 1560
ttagctgtga gcgggcgcac ccctcaggca gtgatgatgt gctgagcccc aagcagccaa 1620
aatgtcaatg actataagac attcagccac aggaaccaaa gtcaccggca cctcaaatgg 1680
ccagaggcac cccacagcag ataagcacca taggtcactg cttttgtccc caagcctctt 1740
aatgtcacca gtttaatttt tcccttaagg agacctggaa atattgtcac atgggttcca 1800
atatctaaga acaccagaaa aatatgaatt cctttttccc cctttttatc ttttaaagga 1860
atattattaa ttttaaaagc agggaccatg ctaatcatct ctatatcatt ccaatttcag 1920
tatatgtgct gctgaagcaa gcatgtcttt ttttttttaa tttttaaatt ttaaatttta 1980
tgagcacata gtaagtggat atatttaata ggtacgtgag acattttggt acaggacgca 2040
atctgtaata atcacatcat ggaaaatggg gtatccatcc tttcaagcat ttatcctttg 2100
tgttaaaaac aatccaatta tactcttagt tattttaaaa tgtacaatta agatattatt 2160
gactatagtc ttcctgttgt gctgtcaaac attaggtctt tttcattctt ctgttttttt 2220
ttgttttttt ttttgttttt ttcttttttc agatggagtt ttgctcttgt tgccctggct 2280
ggagtgcaat ggcatggtct cggctcactg caacctgcgc ctcccgggtt caagtgattc 2340
tcctgtctca gcctcctgag tagctgggat tataggcaca caccaccatg cctggctaac 2400
ttttgtattt ttagaagaga cagggtttca ccatgttggc caggctgatc ttcaactact 2460
gacctcaggt gatccacccg cctcagcctc tcaaagtatt gggattacag gcacgagcca 2520
ccacatccgg ccctttttca ttaaccatcc ccacctcctc tcccgcttcc tcccacttcc 2580
actacccttc caagcctctg gtaaccatcc ttatattctc ttatctccat gagttcaatt 2640
gttttgattt ttagatcctg caaataactg agaacatcca aagtttgtct ttctgttcct 2700
ggcttattat aagaactcct gttttatctt gacaggaata tagagtgact gacctccagt 2760
ggggaggaaa ccagagaccg tggccccatt cccaactggg ccattcagcc tgagacattt 2820
ggatttgata gaacctcttt gatagaacca tggcttattg atgaagtgga aggagtgata 2880
cccgaagtac ccagcccacg gtgtagacat caacctacag gggtgcggaa gctggacaca 2940
ccacccagcc tgcacaagat ttagctggct attctccatt tttattcttt ggataatgag 3000
tttctgctct gtaaatgccc ttatgaactg tgtttggttc cctctcagat gcctcaggga 3060
ccaccagagg acctcttcct cttccctctc agggttctca gggatcaact gagtatccat 3120
ttcctgagtt ctctagctct cgggaatgaa caaccataca agtgtccaac aatcagaggg 3180
tggcttgcca ctgtcctatt ctatatttct ttctctctgc cccagtcagt gcagccagct 3240
cactcatatc cgcagggttg ggggtgacct atgtcctgtt tacaaaaaga gtcaaactgt 3300
aaaacatttg aagagattta ttctcagcca aatatgagtg accaatggcc tgtgacacag 3360
ccctcaggag atcctgaaaa catgtgccca aggtgatcgg ggcacagcca ggttttatag 3420
agtttaggga ggcatgagac atcaatcaaa cacatgtaaa aaattcattg gttgggtctg 3480
gaaaggcagg acaactcgaa gctgagaaag ggtggtgggg tgagggtgtg gcttcctggt 3540
tataggtaga tttaaaattt tgtgattggc aactggttga aagagttatt atcaatagga 3600
aggaatgtct gggttataat gataaggggt tgtggagaac aaagctttat tatgcagatg 3660
aagccttcag gtagcaggct tcagagagaa tagattgtaa atatttcttg tcagacttga 3720
ggtatgtgtt gatgttaatg ctggtcagct tttcctgaaa gccaaacttg agtggggtat 3780
aattggccct tctttcctgt catgacctga accagataat caggtaaact ttggaatgcc 3840
ctggccaaga ggaaaggtcc attcagatgg tgagaaggcc ttcaaatttt attgttggct 3900
tataatctca cctctcattc ttccttttat aaatcatctg gctgcttgtc cagctcctgc 3960
acmcctctag gttgatgtct acaccctggg ctgggtactt cggggtatca ttccttccac 4020
ttcatcaata agccatggtt ctatcaaaga gggccctgct cacttcacca attttgtgaa 4080
ccagattcac catgcactgg tgaattttgt gaacctgcct gagcctggtg agacagaaga 4140
cactcacatg caacaagtta catgaagcaa atgtattact tacagatagg aagcaagaga 4200
caacagaaga ctagaattca ttatgtgcca gtttcccaag gcttatgaaa gctgccttgg 4260
gtggatggag cttcaattgc acatggccta ctgttgttgc agctgagggg ccccaaaagc 4320
agcttacccc aggctcagta cctcaggggc cacaggaatc actgggtaaa tctcatccta 4380
ctttcaggga gagaggaaca aggctctggt tgtcctagca gttcctcctt aattcaatat 4440
gttacattct ttaggagagc caggagccag gcccaggctg tttcaggcag ttcctccctg 4500
cctcaggata tgggcattcc cacacactct acagttgttc ttcagactac aagcaagaaa 4560
tggaggagaa ctgggtcagt gcctggccac ttggagaaca gttctgcaga aagaagtcac 4620
acctgtgaaa actgcctgcc aagaggaaac aactacattg acatgtatgt gagcaagaaa 4680
tcaattgcta tttggttaag ccattgaaac tttctatttt tctttctttt tttttttctt 4740
ttttttgaga aagggtatca ctgtagctca ggttgtagta cagtggcatg ttaatggctt 4800
actgcagcct tgacctccca gatccaagca atccttttga gtatctagaa ccacaggtgc 4860
acactaccat gcccagctaa attttaaact ctctaaagag acagggtctc cctatgtggc 4920
ccaggcttgt ctcaaacttt taggctcagg tgatccttcc acctctcgac atcccatagt 4980
gctgggatta caggagtgag ccgtcttccc tggcctgaaa cttttacata tatttgttac 5040
agcagttgac actactctaa gcaggatata taccttgcat gttcaataaa gaatatatag 5100
aaatagcaac agttttcagg ggaacattgt ctttgaggat gaaactctga ctttttttct 5160
tatcttggcc aaactcctcc ctaagggacc ttgggagtca cccctacaaa ccataaagtt 5220
tcatcagagg ggttttattt aaccctatgt gacgtggttt gctttccaac ctggctctgg 5280
catgacctca cataataaat aaggaaagaa atgaaaatat tttagcccca aatatatttc 5340
cttgtcttga aatgaccctg caaagttgtc tctctcttgt gggaataaaa tctacatctt 5400
tttttttttt tttttttttt tttttgaggc gaagtttcgc tgttgttgcc cgggctggag 5460
tgcaatggcg tgatctcggc tcactgcaac ctctgcctcc caggttcaag cgattctcct 5520
atctcagcct cccgagtagc tgggattaca ggcacatgcc accacacctg gctaattttt 5580
ttggtatttt tagtagagac ggagtttcat catattgttc aggcaggtct tgaactcctg 5640
acctcaggtg atccacccac ctcagcctct taaagtgatg ggattacagg cgtgagccaa 5700
cgtgcccagc ccgttctttt cctttttttt tttttttttt tttttttgag atagagtctt 5760
gctttttttc ccaggctgca ctgcagtagc gtgatcttgg ctcactacaa cttctgtctc 5820
caggttcaag tgatcctcct gcctcagctt ccagagtagc tggcgtgcac ctccacacgc 5880
agctaatttt tctatcttta tttatttatt tattctgaga cgaagtttgg ttcttgttgc 5940
ccaggctgca gtgcagtagt gtggtctcag ctcactgcaa actctacctc ctgagttcat 6000
gtgattctcc tgccttagcc tcctgagtag ttggggttac aggcatgagc caccatacct 6060
agctaatttt tgtgtatttt tagtagagat ggggtttcac catgttggcc aggctggtct 6120
cgaactcctg acctcaggtt atccactcgc cttgacctcc caaagcactt ggattacagg 6180
aatgagcaac cgcagctggc caacttttgt atttttagta gaaatggggt ttcaccatgt 6240
tggccaggct ggtcttgaac tcctgacctc aaataatcag tctgtcttgg cctcccaaag 6300
tgctgggatt acagacatga gccatctcgc ccggccaaaa cttttttttt tttttttttt 6360
gagacaaagt ctcactctgt cacccaggct agagtgtaat ggtatgatta tggctcactg 6420
cagccttgaa ctcccaggct ccgcttccca agtagctggg actacaggtg catgccacca 6480
cgcctggcta atttttgtat ttttgtagag attgggtttt gccatgttgc ctaggctggt 6540
gttgaaatcc tgggctcaag tgatccactg tgcttggctt tttttttctt tttttttttt 6600
gagaccgagt ctcgctctgt cacccagatt ggagtgcagt gactcgatct tggctcactg 6660
caacctccgc tcggctgggt gcggtggctc acgcctgtaa tctcagcact tcaggaggcc 6720
gaggcgggcg gatcaccaga ggtcaggagc tcaagaccag cctgggcaac atggtgaaac 6780
cccgtctcta caggaaatac aaaaattagc caagagtggt ggcgggcgcc tgtaatccca 6840
gctactcagg aggctgaggc aggagaatca ttggaacttg ggaggcggag gttgcagtga 6900
actgagattg cacccatgca ctccatcctg ggcgacagag atagactccc tttcaaagaa 6960
aataataata ataataataa tgttttcatg atgctttgtt gatatctcct tcatcttaac 7020
a 7021
<210> 138
<211> 2457
<212> DNA
<213> Homo sapiens
<400> 138
ttcacattat cctctaagcc atttccagat tgactgtaga tctgaatata aaagtaagca 60
aacaaagctt gtagaataca acatcgggga atatctttat gactttgacc caaggaaata 120
ttttctagac ttgatgctaa aagcgttagt cataaagggc aatccttccc gtctagatct 180
tcaagtcctt cagttctgag aatttttctt atatttcttg gtaaaattat cctccatttt 240
tcctttgtct tgctggaact cccagtaatg agatgatatt gaatctctgg aatgggttgt 300
tcaattttct ttccactact attttccatc tttgatgttt tcctactgtt tttgaagtag 360
ttctaaactg taacttccaa atttttcatt aaatgttttt cttttcccct gctactttat 420
tctttatttc taggagatct tgtttcatta tcataaaaag atagtacccc aagttactat 480
ttccaggtga gatgaagtgt gttttacatt ttttctccta tcaaacacaa ctataagtta 540
tgggcagaat gcatgaaata actatttgaa gactctgata ataaaagagt aaacaaaaga 600
gtgtaaggat ggaaaaagaa caccagaatt atcctatatg ttctccccaa attgagtata 660
gatgtaatgc aattgctatc aaaattccag tagaattttt tggagataga gaaaagctga 720
ttctaaactt tatatggata gatgaaagaa ttagaatagc taaatcaatt ttgaaaaaat 780
gcagtgaata atcacattac ctgattttca gatttaatac caacttcagt aatcaagata 840
gtaargtatt ggcagaaata taaacatgta gatcaattga tcagaacaga gattccagaa 900
ataaatttac acaaatatgg cgaattgatt tttgacaaag gtgcaaataa aataaatgaa 960
gaaattaaaa ttgttcaaca aataatattg ggacaatggg ctatccatat gcaaaggaaa 1020
gaaagaaagg agagaaaagg agagaaagaa aggaaggaaa aaaagtaagg aaggcgtgga 1080
agaaagaagt gaaggaaaag tggaaggaag aaagaaaaga tatcctaaca taaatctaac 1140
aatttataca aaaattaact aaaaaattga tcatatatgc aaatgtaaac ataaaactat 1200
aaaactgtta aaagaaaaca taacagaata tccacatgac cttgagttgg gtgatgagtt 1260
cttagatatg gcactttcca aaaaagaaaa aaaaatacat tggacttaat caacttttaa 1320
cacatttgct ctgcaaaaga aactgttaag acattgaaaa aaataaagac tggcagaaaa 1380
tatttgtaag tcatgtatct gatagagaaa ttttatctag aatatataaa gaatccttaa 1440
aactcagcaa taagaaaaca acccaataaa aattgggtaa aggcataaac actttaccaa 1500
acagagtata aggatggcaa ataagcacac aaaaaatgtt tgacatcatt agccattatg 1560
aaatgcaact ttttttttca caattgcccc aaactggaaa caaatgtcac acaacacaaa 1620
tgtccttcaa tgagtggata aactgtggta catccgtgca atggaattct attcaagagc 1680
aaaaaggaat gaaattttga tatttgtaac aacttgggaa aatcttcatt tatttctttt 1740
ttttgagacg gtgtcttgct ctgtagccca ggttggagtg cagcagcgcg atttaggctc 1800
actgcaagct ccgcctcccg ggttcgcgcc attttcctgg ctcagccttc cgagtagctg 1860
ggactacagg cgcccgccac cacgcccggc taattttttg tatttttagt agagacaggg 1920
tttcatcgtg ttagccagga tggtctcgat ctcctgacct cgtgatccgt cctcctcggc 1980
ctcccaaggt gctgggatta caggcgtgag ccaccgctcc cagccaactt gggtaaatct 2040
taaggcatta tgctaagcaa aagaagctga tctcaaaaag ttacatactg tatgattcca 2100
tttctacatt ttccaaaagg ccaaaatata caaatggaaa gagtatttat gattgtcagc 2160
tgctatgtgt gggattagga tgagactata aaggaacagt gctagggagg cttatggact 2220
gatagaactg gtgtgtatcc tgatatggta atgggtatgt gtatatacat gtaagtgctt 2280
tttaaaagtc aattttactt aatacttttt aaaaatacag atagctccca tttgtggcat 2340
agactgtacc ttctccatgg tttctgtgag aaacactttc accgagctct tgaaagagtt 2400
tattttgagc agggtttgga ggagagaaaa cccggtgaga ccctggagca ctgcacg 2457
<210> 139
<211> 3772
<212> DNA
<213> Homo sapiens
<400> 139
aatcgtacat gaatatgtat taatttagca aatatttact gatttctcca ctctttagaa 60
tgcaataatt agttgttatt ctatgtctgg tagttgctga tgagatattg ttatgtggaa 120
aaaacagaat ccaaaacagt tttgcaagat tatgattttt agtttaaaaa aaactgtatt 180
atgggatgat ttatatatga tarcgtgtac aatttgatgt tttggcatat ttatacatac 240
atgtaacaac taccacaatc aaagtagaga acatttccat gatcctaaaa agttcccttg 300
tggcctgtga tagtgaaacc tgtgaatatg ttatctttca cagcaaaagg aactttgcag 360
ctgtgattaa attaaggatt atgaaatgag gtgattatcc acaattacct ggattgggcg 420
ttgtaatcac aaggatcctt ttaagaggga tcattgtcag agaaggagat gtgacagtgg 480
aagcaaaagt tggaatgatg aggccgggcg cggtggctca tgcctataat cccagcactt 540
tgggaggctg aggtgggcag attgcctgag ctcaggagtt tgagaccagc accaccaaca 600
tggtgaaacc tcatctctac taaaaataca aaaattagcc agtaatcctg actaaatgct 660
cctgtaatcc tcgctactca ggaggctgag tcaggagaat tgcttgaacc cgggaggcgg 720
aggtcgcaat gagcagagat tgtgccactg cactccagct tgggcgacag agtgagacgc 780
cgtcttaaaa aaagaaaaaa agttggagtg ctgcagggcg atgagccaag taatgccagc 840
agcctcttct agctggcgaa ggcaaggaaa cagattctcc tctagagctt acagaaggaa 900
gatagccctg ctgactcact ctagacccct gacatccaga gctgtgagat aataaatttg 960
tgttgtttta agctattaag tttgtggtaa tttttcacag cagtaatagg aaactaatgc 1020
atgccctttc ccagtcagtc acactccgac cacacaattt ccagtcaact ataggccctt 1080
tccatcatga tggttttgcc ttttctggaa tttaatctaa atggattaaa ttatatgcta 1140
tgtactctag ttcctggttt ttgctcagaa catttttgag attcattcat gttgttgcac 1200
atatcagtaa tttattccat ttattagcac tttattggta aaatgtattc tatttgtaca 1260
gacatgccac aatttgtttt tccattcatg tgtgggtgaa catttttatt attttcacat 1320
tctagctatt ataaataggg ctgctgtgca aatttgtgta acaagtcttt gtgtagacat 1380
atataagcca gagttcttca gaaacagaaa accaatagtg tgtgtgtgtg tgtgtgtgtg 1440
tgtgtgcgtg tgtgtgtgta gacagtgatt ttaaggaatg gacttacatg attgtagagt 1500
ctggccagtt cagattctgc acggtatgcc agcaggctgg aaacccagga aaaagttaat 1560
gtggcagcta aaactcaaag gctgtctgct ggcaaaagtc cctcttccta gggagagaag 1620
ttagtctttt ttctcttaag tatttttcaa ctgataggaa gcaatctgct ttactcaaag 1680
tgtactgaat taaatgttaa tctcatccag aagtaccttc acatcaacgt ctaaactagt 1740
gttcgatcaa atatctgaat actatgagct agccatgttg acacgaaaaa ttaaccattg 1800
catatgtttt cacttctttt ccaggaaata cctaggaatg gaattgctgg tcatttagta 1860
agtgggtgtt taactttata agaagctacc agtgttttcc aaagtggtgg ttcactttac 1920
attccaaaaa gcattatatg agagttccag ttgtacaacc tcctcagcat ttgttattgt 1980
cagacttaat gtttatgcaa agatatccta tgacatcttt gcctatttca taatcatgat 2040
tttctcctat atttccttct cagagattta taaattagca cttttgttta ggcctatgat 2100
ctattttcag ttaatttttt tatgtattct aaaataagga tcaaagttaa tttttttcca 2160
tatggctatc tccttgtttc tgcaccattt ttgaaaagac tatcctttcc tcataaagta 2220
cataggcact tttgttgaaa gtaaatttat tatacatgta catctatttt tggagtccct 2280
attttattcc attaatctat atgactttcc taattatact ttaatttgca ggccagttag 2340
gatggctatt atcaaaaacc agaaaataaa ttggtaagga tttattggta aggaacttta 2400
tgtattgctg gtggaaatga aaagcagagc agccactgtg gaaaacagta agattcctca 2460
aaattttctt ttcttttttt ttttttgaca gagtcttgct ctgtccccca ggctggagtg 2520
caaggcgcga tctcagctca ctgcaacctc cgcctcctga gttgaagcaa ttctcctgcc 2580
tcagcctcct gagtagctgg gactacaggc gcacgccgcc atacctggct aatttttttc 2640
gtattttagt agagaccagg tttcattgtg ttgcccaggc tggtcgcaaa ctcctgagct 2700
caggcaatct gcccaccttg gcctcccaaa gtgctgggat tacaggcatg agccactgca 2760
ccctgccaat cctcaaacta ttaaatgtag aattaccata tgatccagca attccatttt 2820
tgcatatata tccaaaataa attaaaacac gggctcagat tcatagcagt gttattcaca 2880
atagccaaat atccatcaac agattaatgg ataaacaaaa tgtggtatac acacaatgga 2940
atattattca gccttgaaag gaaattctgg ctgggcacag tggctcatgc ctataatccc 3000
agcattgtgg gaggcccagg tgggtggatc acctgaggtc aggagttcaa gaccagcctc 3060
accaacatgg cgaaaccccg tctctactaa aaatacaaaa ttagcggggt gtggtggctc 3120
atgcctgtaa tcccagccgg aggctgaagc aggagaatcg cttggaccca ggaggcggag 3180
gttgcagtga gccaagataa caccattgca ttgcactcca gcctgggcaa caagagcaaa 3240
actcagtctc aagaaaaaaa aaaaaaggaa attctgacac atgctaaaac atgaatgaac 3300
cttgaagaca ttatgctaag tgaaataaac caatcacaaa aagatgaata ttttatattc 3360
catttatata acgtaccaaa gtagtacaat ttatagagag ataaagtgga atggtggttt 3420
ccaggggact agaaagaggc aaggatgtgg agttagtgtt taataagtac agtttcactt 3480
ggaaaagatg gaaaagttct ggagacaaat ggtgataatg gttgtacaac aatgtaaatg 3540
tacttaatgc cacagaactg agcacttaaa aatggctaag atggtaaatt ttatattatg 3600
gttgcttaca taataaaata attacacacc agagacctat gacatatgta ttagccacat 3660
ttttaaaaat gataaaagtg taacacctta ttagagactg actcaggtac ctacagcaag 3720
taataggtgg agttgtcagt agcctctcaa actcaggtgt ttgatggtcc ct 3772
<210> 140
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 140
ttttggaagg tgacgagtgt attttgtgag agagactggg gtcataggtg gacagaggtc 60
ctatctggta ggcagcctct aagatgaccc ccaataatct ctacctcctg gtattcttgc 120
cctggtgtag ttccctatgt accaggggtg gtctttgtgt ctaatgtaag tgatagataa 180
gctctagagg gaagccagtt actatgtcac cagcagtcct gtttagtagc ctatttgggg 240
agggagtgag ccttcctgcc aacacccact agggagattg gaagaagatc ctccagacac 300
agtcaagcct tacgatgact agagccctag cctggcatct tgattgcaac cccaggagga 360
accctaagct ggaactaccc aaatacaaca ctttgatttt caagttacag acacagtaag 420
ataataaatg tgttgtttta aaccactaca tttggagtta tttgttacag caattgataa 480
gcaatacaaa tctcaaataa rttaagttta taacttaagg ctccctggac tattcaggaa 540
atgcacttcc aggatgccga tctactgtag gtcacctttg tggctttgat ttatcaagat 600
gaagatattt tctacttctt ttctttactt ggtgcattcc taagtgacaa gactactttt 660
cgggcagttc actagggatg atagttgagt tttctctcta gattattatt aatctgcatg 720
tatgacactg aggacgtgta gagtggttct ccattttcag caggtcctag tgacttcggt 780
tttcctcaat ttagaagctg ccaaagcata agcccaaatt tgcctccatg agcaagagct 840
ctaaaagcat aagcaactgg ttgttgtggt gctctgctta tctgtgttct catttccttt 900
tacatttgtt ttacatgtct cttaggtttc tttaatgttt tatcacttca ttgtctaaaa 960
caaaccttta aagaattgat ttagaacata ttttaataaa a 1001
<210> 141
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 141
caggtacttg ggaggctgag gtgggaggat cacttgagcc tgggaggcag agatttcagt 60
gagccaagaa tgcatcattg cactccagcc tgagcaacag agccagaccc tgcctcaaaa 120
agaaaatata tatgtatatt agtttgataa actccaatat aactttttta cataaaattg 180
attttttaag tttataaata taaatattta aatatgatat ttaaatccaa ttttgctgga 240
aagcctaaac acaatgtgga agctattgac ttgtcccatt atcaatctta catactatta 300
taaaataaat gatataccat tatagcttct cccaactatc caaatgctta tgggttaggt 360
gtgaaaccta caagatgaag caaatgaggc tttatctagg ggtgacagtt ttatggaaag 420
aaatgagtat cagggaaggc tacacaatgc aaaaacaaaa ttctgtgagg acttgaaccc 480
aaggcatttt gcttaccaga yaagtaagtt gaatgacaaa gcaacaattc cctgtcataa 540
aagttaattt atttgctatt acagtataga cattttaaaa cacaccagaa gaattttaga 600
gtttgaaaat gacaagttgc attttgtttt gagcaggaaa catatcaaga caaacttcct 660
tcatactaga cagtattgta atcccagcga ctcaggaggc ccaagcagga ggaccacttc 720
aggccaggaa tttgagatta gcctaggaaa catagcgaga cctcgtctct aagaaaataa 780
attagtcatt gtagtagcac acacctgtag ttctagctac ttggaaggct gaggtaggag 840
gatgacttga gcccaggagt ttgaggctgc agtgaaccat gatcacgcca ctgcactcca 900
gcctgggtga tagatcgaga ccccatttct gggagggtgg gaaaaccaga cattgacaag 960
gcctgagcag aggaggctgc caactgtaga aattgcaagt t 1001
<210> 142
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 142
tatgtaatac tatacatatt tttaaaagaa tgaagaaaac ttgtctattc tgatatggaa 60
agtttgcaaa agtacattgt aagtaaaaat ttaaaaaggc aagggactta aaaagtgtat 120
aaaatgccac tattcatgaa gagaaaaaag aaaacacttg tgtaactttg tctatgtatt 180
caaaatctct ggaacgataa acaagacatt aaaaacaatg gtaaagcttt tgggaaacaa 240
tggctgagta gacaacgatt gggtttaacg gcccctggaa tggtgactag aaccacattt 300
ctagcatttt tcaataccaa ggtcttcgaa gcgacctttg atttgaggtc actttaggaa 360
tctgaaggaa cacataggaa gactcccaaa ttgaggatct agacataaga aacctgggac 420
gatctcgatc atgggaccat cgagaatcag actcgttggg aatatccttc aagtaccaat 480
ttgtatgttg tattagtgag yggcttttac gaagcaaaga ctcattaata tttcaccgaa 540
tctgattcat tgtctgcatg tattgactag acattcagaa ggcagcaaat atttccataa 600
attgctgggc cattagccac agtttgaaat gtttaagcgt cctctttcaa gtctacgaat 660
acagccattt tgctttgttt ttgcgttaag aggaaatttc tcgttatttc tattaagact 720
ctaaagcaac taagaaattg ttcctccctg taagacaaac aggaattacg ttgaagaatt 780
taatactttc acggagaagg ggcgaggatg cgggtgagat gaataacaaa agcacagatt 840
tgcggtcggc cggttagctc agttggttag agcgtgctgc tactaatgcc agggtcgagg 900
tttcgatccc cgtacgggcc tttggctttt tcccccctcg agaaatttgg ttttcatgct 960
ctaagatgat tcaaattaac cgtccccatt tcttaacgaa c 1001
<210> 143
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 143
cgagaccggg tagatatact cccttgggtt ggtgtgagcc tagagactta gggacctcat 60
cagagcaaga aagtgcaagt aggcttttct gcatcatttt ctggccctcc agttcagaca 120
caaatcaaaa gttagtccct tcttgaaagc cattagcatt catcaaggag cctcaatgag 180
aggaagtttc aaacaaaaac taaatgtgtc aggcccagat ttacggtgag ggtctgattc 240
cacttccttg cggggtcagt ttgggtccag gtgagagagg tacagtggtc tctagttttc 300
tggaaacggt actgctgata gggcaaggac tccttgcggc tgccccagag aggttggctt 360
gtcttatcca acttgcactt cacgttagag tttctaatga actcgcagac tccagtttct 420
tgcccaggaa accattttta ccgtattttg ttcttttgac cgtttcttgt cagttagctg 480
gtgtaaattc tgtttaaaga hgtgaaggga gccttctcca ttcgtgtagt cgtggccgag 540
tggttaaggc gatggactag aaatccattg gggtctcccc gcgcaggttc gaatcctgcc 600
gactacggga tgttttactg agaacagttc agcgaggaaa taggatctca catttgcttt 660
cagtttggga gtaaagaaac tcgtgataga gcctctgcgt gtcacctaac atagcctgaa 720
cttttgccga cttcgggatg ttttactgag aacagttcag agaggaaata cgatgtcata 780
tttgctttca gtttgggagt aaaggaactc gtaatagagc ttctgcgtgc cacttaacgc 840
agcctgaact tttgccgact tcgggatgtt ttactgagaa cagagaggaa tcgtatttac 900
ttcagagagg aaatacgatg tcatatttgc tttcagtttg ggggcgaggg aactcgtgat 960
aaagcttctg cgtgccactt gacgcatcct gaactttaaa a 1001
<210> 144
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 144
cgaatccgag tcacggcagt accttgatgt cgcctcaatt tctcaacgta ctgagcagta 60
ccttgacgtc gcctcaattt ttcaacatac tggagtggag acagtctcgg aaaaaccctt 120
gcaaaattga attgacttac gatctaatct gtacacaaaa aacactagta ttcatcatgg 180
tgccccaacc agtcagccaa gcagagagtg tctacgcttg ttgccttgtc ttttttttcc 240
cctctccaaa gattctcttc ccaaccctac ccaagcccta cagtcttgtt ggcattggct 300
gtatgtgaag aaactgaggt aatttttttt taatggaaaa cttttacttt caaacactgg 360
taggcatgag gaaaggactg ttcaaaaggg gatccaggtt tgttgtggag atctttctta 420
aaacacaaaa gacaaattat taatcacgcg tttctaagta tcctagctgg accaatgctg 480
aaaaactgta acctttgatc rtctggagaa aattaaagaa atttgagtaa ttgaaggaat 540
ttgggtgggg gggaataatg gcccagaaga acagccccca tttctagccc gttcagtttc 600
tagaatgagt tctaaagagc caagtagact gggtgaggcg ggagtggagg agagctgatc 660
tgagatacgg aggtggctgg aaagaagtag ttggtgctac ctaggaccag taggaggtgg 720
ctggagacag gcagatcccc agaggcgctt ccatgagccc agttctagtt agtagcacag 780
cactctgaga acacattaat ggcacttcgt ccctcctggc cctggtggaa ggttagtatt 840
caaacaggtg tggtggctca tgcctataat cccagcactt tgggaggccg aggcgggcag 900
atcacctgag gtcgggagtt cgagaccagc atggccaaca tggtgaaacc ccgtctctac 960
taaaaataca aaaattagct tggcatagtg gcataggcct g 1001
<210> 145
<211> 2290
<212> DNA
<213> Homo sapiens
<400> 145
gagggagaga aataacgtga tttctctcac atgaactcag gggccaactt tggatagaac 60
tgaaagctgt acctgagaaa caaagagaaa tattccttcc tccttcattt tatactattt 120
ccagcaccaa aaccttttct tctctctgcc tgcccccttc cacacaaact gtccaactcc 180
attctcattt ccccactgag gtggatgctg tggtgccctg ccctggtcac tccgtgttgg 240
actgagacac acaatcaacc agctgcagag agtgttggtg gctcagggcc ctcagctgac 300
tccataccat gaattgttaa agagccaaag agagccctgt kgcccaaggt tattccacct 360
ctcagtgagt ggaccacatc caatgactgg aaaacatagg tgtaaaggtc ctggacccct 420
tgcacaaggt acacaactct gaagggtcac cccagttcca gagttcattg tgagactgca 480
ttatatttca acttttcctt ctgtctatcc tctttcctta acttcctcaa ggtattgatg 540
ctgcggggct ctccagtgga tgtcctatag tctatttctc tggaaccacc aaagacaggg 600
attcttaaaa gtgtggtctg accctaagat tctttcaggg gatccatgag gtgaagactt 660
tttttttttt ttttttttga gatggagtct cactctgtca cccaggctgg agtgcagtgg 720
tacgatctca gctcactgca acctctgcct cctgggttca agctattctc ctgtctcagc 780
ttcccgagta gccaccactc ctgcctaatt tttatatttt tagtagagat ggagtttcac 840
catattggtc aagctggtct caaactcctg acctcaggtg atccacccat ctctgcctcc 900
caaagtgctg agattacagg tgtgagccac cgcacctggc caagacaatg tttataatga 960
tactaaaatg ttatttgtgg ctgggcatgg tggctcatgc ctgtaatccc aacgctttgg 1020
gagaccaagg caggcagatc acttgatgcc agaagtttga gacctgcctg ggcaacatgg 1080
tgaaaccctg atctctacaa aaaatacata aaattatctg ggcatggtgg tgagttcctg 1140
tagtcccagc tactcaggag gctgatgtgg gaggatcacc tgagcctcgg aagtcgagga 1200
tgcagtgagc catgatcacg cctctacact ccagcttggg tgacagagtg agaactctgt 1260
ttcaaaaaaa aaagaagcga gaggatcact tgagcccagg aattcaagac cagcctggac 1320
aacatagtga gacccccatc tctattttta aaaataaata aataaatttt ttttaagtta 1380
tttgcctctt ttactcacat actctcacat gtgtgcattg gagttttcca gatgttgaag 1440
acatgatgac atcatccctc tgacacctat tggaatgtat gtcacaatgt gtattattgt 1500
gtttaaaatg ctgtgtttta agggccgggc atggtggctc acacctgtaa tcccagcact 1560
cagggaggcc gaggcaagcc gatcacttga gcccaggagt cagacctggc caacatggtg 1620
aaaccttgtc tctatgaaaa ataaaaaaat tagccagaca tggtggtgca tgcctgtaat 1680
cccagctact aggaaactga ggcaggagaa tcacttgaat ttgggaggcg gaggttgcag 1740
tgagccgaga ttgtaccact acactccagc cagggcaaca gagcgagact ctcatttaaa 1800
aaaaaaaaaa aaacctgttt tatttattta tttgagacag ggtctcaatc attcgcctag 1860
gctggagagt agtggtgcca tctagactca ctgcaacctt cacctcccag gctcaagtga 1920
tgttcctgcc tcagcctccc acgtagctga aattacaggt gcatgccacc acacatagct 1980
aatttttgta tttttttgta gagacaaggt ctcactatgt tgcccaggct tgtctcgaac 2040
tcctgagctc aagcgatcca cccaccttgg cctcccaacg tgctggagtt acagatgtgc 2100
accaccacac ccagcccagt tttaattttt aaatgctaag tgttgataga tataactcac 2160
ataaataaaa actctctggg attctcaatt attttcaaga gtataagaag gtcatgagac 2220
caaaacatct gagaattgct gctctaagat aaccaaatct accctgggag gaaaaggctg 2280
aggttttaaa 2290
<210> 146
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 146
gaaacaaata cacatgaaaa tacagtatgg cacaaataag gagcaagagg tgaagaaagc 60
ttcagtcaca cccaaaataa ttttgtgaaa aatataaaat atgcagttat agacagcact 120
aactctggat accagaaaat tctataattc ggtaatggat ctgagacctg aattttggag 180
gtactaaaat agatgcaata gatctagttt tcattatgtt catactttca tttggctctg 240
tggtaaaaga tgataatatc caaaacaaaa gatgataata tcctccatgt aacaattaca 300
tgcaagggga tgtctgcaaa ctgccacagt atcattttaa ttaataccta tcttctcttc 360
ttaaaatctt ttcatttttc cactcagttc tcctgatatt tctgttatga tataaaagac 420
agctgaatgt gaagaaacac tgattgtaca cgtaacacac acattaatga ttcaaatatg 480
taaacacaga gagctgcaaa yactttgaga ggtagggctg aaacttttcg tcaatgtgta 540
caattcaata tcgtttcagt tttcattcta accgtcccca gtggcttctg cccagcaact 600
gatgagaaat ggtacctctg agccaatcaa aacacgaatt cctacaaaga ggattctctt 660
agtgtttctc ggaccgagtg tacagcacat gctttctttt cctttattct ggatcagaga 720
atcttaacta aagcagaaat aattgtgtta aattaaacta aatttggtat gagatatgta 780
tacatttagc ctgagggatg gctcttgagc ccttaaataa tgaactgcaa cctaacttag 840
tatgtaaact aactgaaagc ttaaggcatg ggagtatact tttgtaacaa atagctgagt 900
ctcagccaat cccagtagcc gaacttcagt cggcggcagt caaccctgca gccaagtgat 960
cagactatgt tcaaataagg ccaactctga gctgtaacca a 1001
<210> 147
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 147
gagtttctct tggtctgtgt gggagaagat ggagatcaca gctggagggg gaagacaagg 60
ggttagatgg aaaatgggtg cctcttggga ataggcagct tgctagcttg cttagctact 120
taatctgtga ggttatttcc cggctttcaa aagatgggtt attttggtgt cctgggacat 180
ggacaactgc aatctcttcc ggcagctgaa gattttctag cacttgcata attaattcct 240
tgtgggccaa atcttggccc ttactattga tgaggcctcg ttcagtccag atcttttccg 300
aaggcatact tggagtaagt gtaaatagtt ccttcctgat tctgcaggga ttttaaggct 360
tggtttaatg caaagagttc acatatttgg gcagaccact tatttggcag tctttctgac 420
tctaccactg tgagggtttc cctatcaact atggagtacc cgttgtgcct ttttccttca 480
atgacctggg aggagccgtc yataaagagg tgatgccctg tttggaaggg ggtttcatgc 540
ctggatgcgg tctgactcta gtttgaaaac tgattagatc taagcagtta tgctcacatt 600
cctcctggtt tggatttcct gttaggaaag cagcggggtt gagtgaattg tcagtggtta 660
gtgttaggtt atctccctct aataagatag cttcatattt taaaatcctt gagtcagtga 720
gccatctccc tgccttctga ttaagaatgg ttctgacttg atgaggggca cttacgaaga 780
ggtttccccc aaaggttatt ttcctgcttt cttctgttag caaggcagtt gctgctatgg 840
attgaacaca ttcgggccat ccacgggtta ctgggtcaag gatttttgac agaaagacta 900
caggctgccg gtggcctcca tgtttttggg tgagtacccc taaggccact cctttgctta 960
cattaatgaa aagatggaat ggctgttcta aggagggcaa a 1001
<210> 148
<211> 501
<212> DNA
<213> Homo sapiens
<400> 148
ctccagtgca acctatgggg cttttggaaa tgaggaagtc gatgactctg cagggactcc 60
tctgacccag gagcagatgg cgctcgtctg ggcactcccc aggagaaaag gtgcatcggg 120
aagcagcctg gcttgtggat ggtaataagt cactgttgat gggttgggtg cagggaggga 180
tttaagttct tgagcgacag atgctaggga gtttacctgc tctggataac agtatcttgt 240
ggaggatagt yacctggaaa acagaaatgg cgtgactgtg ttgaatacac tgtttgatga 300
ttctgggcat caggtgaata ggaaatgtgt aacgttatgg atgagtgtgt gctcatcgga 360
cagtagcagt gcatcttaac agtcggcctc tcagtcctcc tcttccttag aatcacctat 420
agagctttaa aatttcctgg ataatgttaa tgtgcagcca gcgatgatga ccattgggct 480
acagtcaaat ccaagaggcg c 501
<210> 149
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 149
cccacctcgg cctcccaaag tactgggatt acgggcatga gccaccatgc ctgtcctaca 60
tatatcttat tcattgtctt attcaatcat acaacttcct gataaaatga ggctgatttt 120
cacccctatt ttgctgttaa ggaaactggt ataatgagtg tcactgactt gtttgtgatc 180
acacagtgga caaaatggca tttgtttctt tgtggtgatc tcacaaaggt caagatgacc 240
ttagatcctc agttttggct gttttttttt tgttgttttt ttgtttgttt gtttgtttta 300
caccaaggaa ccaggttcta gctcctatgt ttgttcattg catggaaagg aacaggaaga 360
tctgggggcc actgaatgga aggttagatc cattttcttg gttaagcttg taggttttct 420
cgtctctttt ccttcctgca gcacaattct tatgaatggc aatatcttct attaaaattc 480
tcagtctgta gtcttcttgt ycatacagaa aatagatttc aggtcaacac atttgatagt 540
ctggactgtg ctaactgctc caatatttga gtacatcttt tggggatgtg ggaatttagt 600
gttgtaggcc tcaagtgggg ttcgttccca gaatttggag aggctataga aatataacct 660
ggttggccag gcacggtgac tcatgcctgt aaccccatca atgtgggagg ccgaggcagg 720
tggatcacct gaggtcagga gttcgggacc agcctggcca acatggagaa accctgtctc 780
tactaaaaac ttttaaaaaa ttaggcgggc gtggtggtac gtgcctgtaa tcccagctac 840
ttgggaggct gaagtaggag aatcccttga acccgggagg tggaggttgc agtgagctga 900
gatcacacca ttgcactcca gggcaacaga gtgagactcc atctcaaaaa aaaaaaaaaa 960
agaaaaagaa atataacctg gccataatat aagcataaat a 1001
<210> 150
<211> 1181
<212> DNA
<213> Homo sapiens
<400> 150
gaggtcctgg ctgagccaag gagtaatgga ccagatctac ctcagtattc aagttcagtg 60
gggacaccag tggcttcaaa cttcctggtt tcatgatatc ttgagacgcc ttacaaatga 120
tggaggattc caaagagttt ttgtttattt gggttaatat ttgttggtat ttatggcatt 180
tgagattgaa actaagaaat gttttaattt attaccttta caacatttat ttacattaca 240
tacatacatt tacaacattt attaatttat attaaaatag catgaataag ccaattatag 300
gttaatataa gtagaatgtt tgtgaaaaat aagtatggta tccaaagcaa aataaatttt 360
attgtgaagt gtggcattga ttvacttttt ccagatctaa tgtgtggctt gaaagaatat 420
gactggattc tcatatctgc ctttatactc actctgttga gatatcatag actatatagg 480
ctcaagaaaa ctttatccta gtgacagaat gagattaaaa acaacaaact gtgttttatt 540
attaatatga aaatacgatt attaaccttg caggcccctt aaaacagttc tggttaactg 600
agaccttgtc tctaccaaaa acaaacaaaa aaaattaggt gtggtagcgc acgcctgtag 660
tccctgcttc aggagactaa aaagactaac tccaactcct tgcttgagcc aggagttgga 720
gtttgcaatg agctgtgatc ctgccattgc actccagcct aggcaacaga gtgagactct 780
gcctcaaaaa accaaaacac aggtcgggca cggtggctca cgcctgtaat cccagcactt 840
taggaagccg aggtgggtgg atcacctgag gtcaggagtt caagaccagc ctggtcaaca 900
tggcaaaacc ccatctcact aaaaatacaa aaattagcca ggcatggtgg cgggcaccta 960
taatcccagc tactcaggag gctgagacag ggaatccttg aaccccagtg gggtggaggt 1020
tgcagtgagc caagatcgtg ctgcttcact ccagcctggg tgaaagagtg aaactcccgt 1080
ctcaaacaaa gagggggagg gaacttatgt cagagacccc ccccacccca ccccaggaat 1140
cctgaaacca tatttgagag ttgggataga ggattcggga a 1181
<210> 151
<211> 1205
<212> DNA
<213> Homo sapiens
<400> 151
ttatgggaag aatcaggaac atatatttaa atacctgatt tgttaaggca gaaaacaggg 60
ttgtttatgt gcatgtttta gtctgcccag acagctatga caaatatacc aagactgagt 120
cgtttataaa caaccaaaat tttttttctt gcactctggg ggctgggaaa tgtaagacca 180
aggcaccagc agtttggtaa ctggtaagag cctgcatcct tgttcacagc cttttaaatg 240
tgtcctcata tggcaaagga gaaaagtaga tctttggttt ttgtcccaag aaactggaaa 300
gatgggccgg gcacggtggc tcacgcccgt catcccagca ctttgggagg ccaaggcagg 360
tggatcactt aaggtgagga gttcgtgaac agcctggcca acatggtaaa accctgtctg 420
tactaaaacc cagaaggtgg aggttgcagt gcaccactgc actctagcct gagtggcaga 480
gtgagactct caaaaaagaa aagagagaga aggaaggaag gaaaggaagg aaggaaggaa 540
ggaaggaaaa gtaactggaa agatgaagtt gttaatttct gagatgggga aacggagaga 600
caaggagcaa gacgggagtg gtacagaacc aaaggttcag ttgtggatac attaaggttg 660
aggagtctat attagagatg cacatggaga tgcagagtag tccattgaat aaccaagagt 720
ccaggtgaga cctcaaggct ggagrtagag attccatact caactttcct atatgtttga 780
agagtttcat gatacactgt agtgggtaga gggaagaatt gtattttgtt attaataaca 840
gtcctgaata tcattggctt tgacaaaatg aggacttctt ttcatgtcaa taaatatgga 900
tggtggccat caagggctga tctgagagct tgaaatgtca tacatgcccc agcttagttc 960
tgtctttatt ttcttctgtc ttagcatgtg gcttgcatct tcaatgttgc ctcatggtca 1020
caaaagggct gcccagctcc aaagtccata ttctagataa gaggaagtag aaagtaaggg 1080
gagtgtaagg gtctaccagc tgttttagcc tccccttaaa taatctgtct gataaacttc 1140
caccctcaag caattggctc aaacttagtc ccttggcttc ccctgtctac aaatgagatg 1200
gacac 1205
<210> 152
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 152
cttgtcagat cccagccccc tggttgagat tttcctggac tatgaagcag gaggcatctc 60
cttctacaac atgagtgaca gaacccctta tctatgcttt ccccaaaggc tctttctctg 120
gctcccttca gcctttattc ttcttgtggt catgcgataa aaagcccctg accacctgcc 180
caattgttga tggactttca ggaggtcaca gtcttgtgaa gcctggggcc taaggagatt 240
ctgttgtcca gaattcagaa aattctgcct ccagaaatac aaatatgctc ttttctaaac 300
aagtgacaac acaatgtagc cataggctcc cttaagcagc cacctcatgt caactaatag 360
tctttgctct ctagcctctc tcctccaaag tccatttcgt ctcctgaggc ttcagctatt 420
actgtcagac cctcagttac ttctgatgaa cagggattag gcttgagaaa atggagatgc 480
atttagattg gcagatatgg rggacttctt aatgtgcttt tattgctgcc ttatctctga 540
aaacaggttc tgggagtttg ggaataagtc tgagggcata taaaggattg agactgagtg 600
acttaggagt gtgagaggaa atatcttgat gttgagaaca gggttgatgt ggaggggtat 660
tctctgtgtt atgcatgtaa aaagaaaaaa aggaaaaaaa aatcattact gggaaagaaa 720
acaccccaag ctgaagtcca agaaaggtac acagaggaaa cacagaaaca gttgtgttag 780
cagaagatga catgaaaccc agctgacagt gaaattagga agttgccttg gaatttcaag 840
aacttgcatt ctcaagttta tggttctgtg tccaacagag cagcaaaatc cagcacttct 900
tcttttgagt ctccatatcg tgctaacaga aagacaaggg gtcgggagat gcagagatga 960
ggaggagctc aagagtgaca gtgttgaaga gattctgagc a 1001
<210> 153
<211> 4000
<212> DNA
<213> Homo sapiens
<400> 153
atatagtgtt tgacacatcc atagtttcag gcatccactg agggtcttgg aacatgtccc 60
ccaaggataa gtggggacta ctctagtgcc atcaggctag caggctgtaa aggttttaat 120
ggcagtccct ggaccatggc ttatttaatt gcttccaagg cccactgcta caaagggcct 180
cattcaaagc tggtggcttt gttggtcacc ctgacttagg ggaccaaaag aacactcagg 240
tggggtacat gttgcctcca atgcccaagt acccaaagag gccttccagc tgttgggcct 300
cctttttatt agtggatgtc tccaaaatta aatttttttg cttggttgta tctagaatac 360
ttttctggct tactgcccat gtggccttcg catttagccc agggacagtc cactgttagt 420
ctccacatcc gaaagccttt ttgactagcc aaactgagct gttacattat gacagggtag 480
tttgtagcat ttccatttgt aacaataatt aacacaataa tgtcctgttc ttcagttagt 540
atgcagtact gtttttttga ataacccact gggacttggg tggcttaggt ggcagacagg 600
catggatatg ccccgccgta acggctggaa ttcttagctg tgagcgggcg cacccctcag 660
gcagtgatga tgtgctgagc cccaagcagc caaaatgtca atgactataa gacattcagc 720
cacaggaacc aaagtcaccg gcacctcaaa tggccagagg caccccacag cagataagca 780
ccataggtca ctgcttttgt ccccaagcct cttaatgtca ccagtttaat ttttccctta 840
aggagacctg gaaatattgt cacatgggtt ccaatatcta agaacaccag aaaaatatga 900
attccttttt cccccttttt atcttttaaa ggaatattat taattttaaa agcagggacc 960
atgctaatca tctctatatc attccaattt cagtatatgt gctgctgaag caagcatgtc 1020
tttttttttt taatttttaa attttaaatt ttatgagcac atagtaagtg gatatattta 1080
ataggtacgt gagacatttt ggtacaggac gcaatctgta ataatcacat catggaaaat 1140
ggggtatcca tcctttcaag catttatcct ttgtgttaaa aacaatccaa ttatactctt 1200
agttatttta aaatgtacaa ttaagatatt attgactata gtcttcctgt tgtgctgtca 1260
aacattaggt ctttttcatt cttctgtttt tttttgtttt tttttttgtt tttttctttt 1320
ttcagatgga gttttgctct tgttgccctg gctggagtgc aatggcatgg tctcggctca 1380
ctgcaacctg cgcctcccgg gttcaagtga ttctcctgtc tcagcctcct gagtagctgg 1440
gattataggc acacaccacc atgcctggct aacttttgta tttttagaag agacagggtt 1500
tcaccatgtt ggccaggctg atcttcaact actgacctca ggtgatccac ccgcctcagc 1560
ctctcaaagt attgggatta caggcacgag ccaccacatc cggccctttt tcattaacca 1620
tccccacctc ctctcccgct tcctcccact tccactaccc ttccaagcct ctggtaacca 1680
tccttatatt ctcttatctc catgagttca attgttttga tttttagatc ctgcaaataa 1740
ctgagaacat ccaaagtttg tctttctgtt cctggcttat tataagaact cctgttttat 1800
cttgacagga atatagagtg actgacctcc agtggggagg aaaccagaga ccgtggcccc 1860
attcccaact gggccattca gcctgagaca tttggatttg atagaacctc tttgatagaa 1920
ccatggctta ttgatgaagt ggaaggagtg atacccgaag tacccagccc acggtgtaga 1980
catcaaccta caggggtgcr gaagctggac acaccaccca gcctgcacaa gatttagctg 2040
gctattctcc atttttattc tttggataat gagtttctgc tctgtaaatg cccttatgaa 2100
ctgtgtttgg ttccctctca gatgcctcag ggaccaccag aggacctctt cctcttccct 2160
ctcagggttc tcagggatca actgagtatc catttcctga gttctctagc tctcgggaat 2220
gaacaaccat acaagtgtcc aacaatcaga gggtggcttg ccactgtcct attctatatt 2280
tctttctctc tgccccagtc agtgcagcca gctcactcat atccgcaggg ttgggggtga 2340
cctatgtcct gtttacaaaa agagtcaaac tgtaaaacat ttgaagagat ttattctcag 2400
ccaaatatga gtgaccaatg gcctgtgaca cagccctcag gagatcctga aaacatgtgc 2460
ccaaggtgat cggggcacag ccaggtttta tagagtttag ggaggcatga gacatcaatc 2520
aaacacatgt aaaaaattca ttggttgggt ctggaaaggc aggacaactc gaagctgaga 2580
aagggtggtg gggtgagggt gtggcttcct ggttataggt agatttaaaa ttttgtgatt 2640
ggcaactggt tgaaagagtt attatcaata ggaaggaatg tctgggttat aatgataagg 2700
ggttgtggag aacaaagctt tattatgcag atgaagcctt caggtagcag gcttcagaga 2760
gaatagattg taaatatttc ttgtcagact tgaggtatgt gttgatgtta atgctggtca 2820
gcttttcctg aaagccaaac ttgagtgggg tataattggc ccttctttcc tgtcatgacc 2880
tgaaccagat aatcaggtaa actttggaat gccctggcca agaggaaagg tccattcaga 2940
tggtgagaag gccttcaaat tttattgttg gcttataatc tcacctctca ttcttccttt 3000
tataaatcat ctggctgctt gtccagctcc tgcacacctc taggttgatg tctacaccct 3060
gggctgggta cttcggggta tcattccttc cacttcatca ataagccatg gttctatcaa 3120
agagggccct gctcacttca ccaattttgt gaaccagatt caccatgcac tggtgaattt 3180
tgtgaacctg cctgagcctg gtgagacaga agacactcac atgcaacaag ttacatgaag 3240
caaatgtatt acttacagat aggaagcaag agacaacaga agactagaat tcattatgtg 3300
ccagtttccc aaggcttatg aaagctgcct tgggtggatg gagcttcaat tgcacatggc 3360
ctactgttgt tgcagctgag gggccccaaa agcagcttac cccaggctca gtacctcagg 3420
ggccacagga atcactgggt aaatctcatc ctactttcag ggagagagga acaaggctct 3480
ggttgtccta gcagttcctc cttaattcaa tatgttacat tctttaggag agccaggagc 3540
caggcccagg ctgtttcagg cagttcctcc ctgcctcagg atatgggcat tcccacacac 3600
tctacagttg ttcttcagac tacaagcaag aaatggagga gaactgggtc agtgcctggc 3660
cacttggaga acagttctgc agaaagaagt cacacctgtg aaaactgcct gccaagagga 3720
aacaactaca ttgacatgta tgtgagcaag aaatcaattg ctatttggtt aagccattga 3780
aactttctat ttttctttct tttttttttt cttttttttg agaaagggta tcactgtagc 3840
tcaggttgta gtacagtggc atgttaatgg cttactgcag ccttgacctc ccagatccaa 3900
gcaatccttt tgagtatcta gaaccacagg tgcacactac catgcccagc taaattttaa 3960
actctctaaa gagacagggt ctccctatgt ggcccaggct 4000
<210> 154
<211> 1181
<212> DNA
<213> Homo sapiens
<400> 154
gaggtcctgg ctgagccaag gagtaatgga ccagatctac ctcagtattc aagttcagtg 60
gggacaccag tggcttcaaa cttcctggtt tcatgatatc ttgagacgcc ttacaaatga 120
tggaggattc caaagagttt ttgtttattt gggttaatat ttgttggtat ttatggcatt 180
tgagattgaa actaagaaat gttttaattt attaccttta caacatttat ttacattaca 240
tacatacatt tacaacattt attaatttat attaaaatag catgaataag ccaattatag 300
gttaatataa gtagaatgtt tgtgaaaaat aagtatggta tccaaagcaa aataaatttt 360
attgtgaagt gtgrcattga ttaacttttt ccagatctaa tgtgtggctt gaaagaatat 420
gactggattc tcatatctgc ctttatactc actctgttga gatatcatag actatatagg 480
ctcaagaaaa ctttatccta gtgacagaat gagattaaaa acaacaaact gtgttttatt 540
attaatatga aaatacgatt attaaccttg caggcccctt aaaacagttc tggttaactg 600
agaccttgtc tctaccaaaa acaaacaaaa aaaattaggt gtggtagcgc acgcctgtag 660
tccctgcttc aggagactaa aaagactaac tccaactcct tgcttgagcc aggagttgga 720
gtttgcaatg agctgtgatc ctgccattgc actccagcct aggcaacaga gtgagactct 780
gcctcaaaaa accaaaacac aggtcgggca cggtggctca cgcctgtaat cccagcactt 840
taggaagccg aggtgggtgg atcacctgag gtcaggagtt caagaccagc ctggtcaaca 900
tggcaaaacc ccatctcact aaaaatacaa aaattagcca ggcatggtgg cgggcaccta 960
taatcccagc tactcaggag gctgagacag ggaatccttg aaccccagtg gggtggaggt 1020
tgcagtgagc caagatcgtg ctgcttcact ccagcctggg tgaaagagtg aaactcccgt 1080
ctcaaacaaa gagggggagg gaacttatgt cagagacccc ccccacccca ccccaggaat 1140
cctgaaacca tatttgagag ttgggataga ggattcggga a 1181
<210> 155
<211> 4000
<212> DNA
<213> Homo sapiens
<400> 155
agacgtttac ctggagttgg tcctttttag ccgccagaaa gatacaggga ttaaaaacac 60
aaattgtaaa ttgagtgata atatttctta caaaggtaac attaaaactg tgttgagtcc 120
tattactatt attggatagt gtcctgaccc agatgctgcc attcataaat gggagtgcta 180
acttccatat cgactgctga attgggcccc tctttccttg atgacgccgc tgaggcaaag 240
gcggactaaa gcctgttccg tgccaagcca gttgcgtggc agattaggat tgaatcccaa 300
tgcgatatag cgaagaaatg ttaaatgttc accaccagtg gcagcgaagt ttgttccatg 360
aggtctgatt ctcatctctc ccaaatgacc acagggaccc cagtcaataa tgtctcccat 420
taacatagac ttgtctagct aaggggtcaa gacactggat ccaaggaggg gggtgagaat 480
tattgaaggg agcccattct gtataatcaa tacaatttgg acgatggggc tgggagagat 540
tagtaaatcc accagtaata ttattagagc taaggcctaa taggtacata atgtttccat 600
ggtgactcaa ccatgcctgg gattggactg caaggcaact gccattgagc gatgtatcct 660
tggtgatgca taaagggagt ccctccaatg gggcagtgta attgatacta ttgttctgac 720
agtctaatag ttctgtgtca gggggagtta ggggtcctgg ggtccatgct ccctgatcac 780
gatatacctc aggaggagtg tcactccaga gtacaggtcg cactactcag gggttaggaa 840
catatgcccg acatgttttt gcttctacac aggggaaaca taccacacag gacactacag 900
ctagtatggc caagaacatt gattcagggg tttttgcctg accctggcac tccagcattt 960
tctcagcttc ctgcatggtt ttcttgatct gtccccatgt tatgagggtg gatgtcaatg 1020
tgactccagt cggcccttgt tccatctttg cattcagatt caactggcct atggcttgta 1080
ctgggggaac cgggcccatg gttgcgatcc acggatccct ccagtctccc gttccatggt 1140
tgcacgtacc tggagggcac ctacacagtt tgtccatctc ctgtaaaaac acaagcatac 1200
cctcatcccc acatcagcaa atccactggg cctttccttt gtccttcttc tggggatttc 1260
cataacacct ttggataaac ttgcctcttt ccctctaaca cttgccaatg ttgttctgct 1320
agagtcttac catccatacc aggcatcaaa aaatttaaag taaacaagac taaatgtaat 1380
tttgtttaag gtggtagctg gtctcctatt cccccttttt ttctcaacat acgctgtagt 1440
gtttgatgtg cccgctctat aatgccttgt ccttggggat tgtaaggaat tcctgtttta 1500
tgaatgattg cccataactg taaaaaattt tgaaaagcat gactaacata agcaggtcca 1560
ttgtcagttt ttaattgttt agagaccccc atatgggcaa atgacgacaa acaatgccat 1620
tggacatggc cagcagtttc ccctgtttga catgtggcat gtaacatatt ggagtaggtg 1680
tctatagtca catgaacata gctaagtttg ccaaaggctg ctgtatgtgc aacatccatc 1740
tgccagattt catttggagc caagcctcgt gggtcgcatc cttccacggg tgcaacacca 1800
gggacatgct gacaagtgga gcaggcttgc acaatagctt gagcttgact gcaaggcaga 1860
tgaaacatat gagtaagggc agaggtgttt tgatgcagta atgcatggga agcttgggct 1920
tgttggaata cagaaccaat taatttatct gctttatcat taccttgaga tagtggtcca 1980
ggaagttgcg tatgagagcr aataggagca gcacaagaga gaatagcttg ctgaagtctt 2040
agaaacaaat taagcagctc tggttctagg gtgcccttaa tagtggcagt ctcaatgcaa 2100
ctagctgcat ttacaacata ggctgaatca caaacaatat taataggaga taaagccgtg 2160
agctctaaaa cctgaataac tgcgattaac tctgagcatt gagctgaaac tccagagatc 2220
tttattgttt gagtatgttt agttgcataa atagctgtgc ggcctttgta agagccattg 2280
gtaaaatatg tctttccacc tggaatgggc ttgtgatggg taattacagg gaggataaaa 2340
gggtgaactt tataaaattg caaaatcttg tctgatggat aatggttatc tattattccc 2400
acaaaatctg caaaagcaat ttgccatgca gtcgacattt cccatgctgc ggcctgttgt 2460
tgggaatcca agggaacaat aattttatca ggatcatatc ccgtaagcat tttttacctg 2520
tgcctaccta ttgttataag ttgagtaatt aaagaaagat aaacttgcaa agatttcact 2580
gtcagattga ataaaaaaaa aaaaagcctt tatattacca ttacagattt gtctatgaat 2640
tggcctaaaa atcctgatgg agaatggggg gtaggaagaa taaacaaaag caaaggcttt 2700
tgtggctgta gccgggaggc atgttgttgc tgaaggatct gttctacacg ctgtcactca 2760
gcttctgcct cgttagtaag ttgccgagga gaatctaatg aagaatctct ttggagggtt 2820
tgataaaggt gtgtgagttg gtagatggca atacctagca tcaggcacag ccaattgata 2880
tcccctaata attgttggaa gtcattcaga gtttgtaccc tctccctaca gagagttact 2940
ttctgaggcc gaacacttct tccagtaaca atagtaccta agtactggta tggggaggtt 3000
gtttgcacct tttcaggagc tattttgaga ttccatgcag tcaagactca ttttatttcc 3060
ctgaataact gatgtaacat ttgatctgta ggagcggcca aaagaatatc atccatataa 3120
tgaatgatgt aggcattggg aaatatattg cgaggctcct ttaaagcttt tcctacaaaa 3180
tgctgacata acataggact gttgagcatg ccttgggcta aaactttcca ctgagagcga 3240
gagacaggct ctctttgatt aatagaaggc acagagaagg caaattgagg cttatccttt 3300
ttgtgtaatg gtatattaaa aaaaaaactc tttaagacct attactacaa gagtccaatc 3360
tcttggaatg gctgctgagg atgacagacc ttgctgtaat gcacccactg gtttaatctg 3420
tgcatttaat agctctcaaa tcatgtagca gttgccattt tcctgacatt tttggatcac 3480
aaatacaggt gaattccagg ggctgactat tctgtatgtt ctgcttccag ttgctctctc 3540
actagctgat ggagttgcat cagtttctcc tgtgataggg gccattgatc cacccacaca 3600
ggtttgtcag tcagccactc tagcggcaaa gcagtgggtg gaggagaaat accaatgacc 3660
cccaccaaaa atcctgatga cctagccctt ttctgttttg tccagttatt gatattggat 3720
cagggtttcc ctgcaggggc tttcctaagc cttttccact ctgaatccca ttttctttaa 3780
cattttaaat cctggattat caatagtttc ctttttaagt ctcatgtccc atgctgtcag 3840
taaatctcgg ccccatagat taacagctat atttgcaaca taaggttgaa aagtacatga 3900
ctgtccatgt ggtctgagac aggataaaat ctcagcactc cactgaacac tttgagcttt 3960
cctagtccca ctaaggatgt agaagttaat tgcaggggtc 4000
<210> 156
<211> 3639
<212> DNA
<213> Homo sapiens
<400> 156
agttagtatg cagtactgtt tttttgaata acccactggg acttgggtgg cttaggtggc 60
agacaggcat ggatatgccc cgccgtaacg gctggaattc ttagctgtga gcgggcgcac 120
ccctcaggca gtgatgatgt gctgagcccc aagcagccaa aatgtcaatg actataagac 180
attcagccac aggaaccaaa gtcaccggca cctcaaatgg ccagaggcac cccacagcag 240
ataagcacca taggtcactg cttttgtccc caagcctctt aatgtcacca gtttaatttt 300
tcccttaagg agacctggaa atattgtcac atgggttcca atatctaaga acaccagaaa 360
aatatgaatt cctttttccc cctttttatc ttttaaagga atattattaa ttttaaaagc 420
agggaccatg ctaatcatct ctatatcatt ccaatttcag tatatgtgct gctgaagcaa 480
gcatgtcttt ttttttttaa tttttaaatt ttaaatttta tgagcacata gtaagtggat 540
atatttaata ggtacgtgag acattttggt acaggacgca atctgtaata atcacatcat 600
ggaaaatggg gtatccatcc tttcaagcat ttatcctttg tgttaaaaac aatccaatta 660
tactcttagt tattttaaaa tgtacaatta agatattatt gactatagtc ttcctgttgt 720
gctgtcaaac attaggtctt tttcattctt ctgttttttt ttgttttttt ttttgttttt 780
ttcttttttc agatggagtt ttgctcttgt tgccctggct ggagtgcaat ggcatggtct 840
cggctcactg caacctgcgc ctcccgggtt caagtgattc tcctgtctca gcctcctgag 900
tagctgggat tataggcaca caccaccatg cctggctaac ttttgtattt ttagaagaga 960
cagggtttca ccatgttggc caggctgatc ttcaactact gacctcaggt gatccacccg 1020
cctcagcctc tcaaagtatt gggattacag gcacgagcca ccacatccgg ccctttttca 1080
ttaaccatcc ccacctcctc tcccgcttcc tcccacttcc actacccttc caagcctctg 1140
gtaaccatcc ttatattctc ttatctccat gagttcaatt gttttgattt ttagatcctg 1200
caaataactg agaacatcca aagtttgtct ttctgttcct ggcttattat aagaactcct 1260
gttttatctt gacaggaata tagagtgact gacctccagt ggggaggaaa ccagagaccg 1320
tggccccatt cccaactggg ccattcagcc tgagacattt ggatttgata gaacctcttt 1380
gatagaacca tggcttattg atgaagtgga aggagtgata cccgaagtac ccagcccacg 1440
gtgtagacat caacctacag gggtgcggaa gctggacaca ccacccagcc tgcacaagat 1500
ttagctggct attctccatt tttattcttt ggataatgag tttctgctct gtaaatgccc 1560
ttatgaactg tgtttggttc cctctcagat gcctcaggga ccaccagagg acctcttcct 1620
cttccctctc agggttctca gggatcaact gagtatccat ttcctgagtt ctctagctct 1680
cgggaatgaa caaccataca agtgtccaac aatcagaggg tggcttgcca ctgtcctatt 1740
ctatatttct ttctctctgc cccagtcagt gcagccagct cactcatatc cgcagggttg 1800
ggggtgacct atgtcctgtt tacaaaaaga gtcaaactgt aaaacatttg aagagattta 1860
ttctcagcca aatatgagtg accaatggcc tgtgacacag ccctcaggag atcctgaaaa 1920
catgtgccca aggtgatcgg ggcacagcca ggttttatag agtttaggga ggcatgagac 1980
atcaatcaaa cacatgtaam aaattcattg gttgggtctg gaaaggcagg acaactcgaa 2040
gctgagaaag ggtggtgggg tgagggtgtg gcttcctggt tataggtaga tttaaaattt 2100
tgtgattggc aactggttga aagagttatt atcaatagga aggaatgtct gggttataat 2160
gataaggggt tgtggagaac aaagctttat tatgcagatg aagccttcag gtagcaggct 2220
tcagagagaa tagattgtaa atatttcttg tcagacttga ggtatgtgtt gatgttaatg 2280
ctggtcagct tttcctgaaa gccaaacttg agtggggtat aattggccct tctttcctgt 2340
catgacctga accagataat caggtaaact ttggaatgcc ctggccaaga ggaaaggtcc 2400
attcagatgg tgagaaggcc ttcaaatttt attgttggct tataatctca cctctcattc 2460
ttccttttat aaatcatctg gctgcttgtc cagctcctgc acacctctag gttgatgtct 2520
acaccctggg ctgggtactt cggggtatca ttccttccac ttcatcaata agccatggtt 2580
ctatcaaaga gggccctgct cacttcacca attttgtgaa ccagattcac catgcactgg 2640
tgaattttgt gaacctgcct gagcctggtg agacagaaga cactcacatg caacaagtta 2700
catgaagcaa atgtattact tacagatagg aagcaagaga caacagaaga ctagaattca 2760
ttatgtgcca gtttcccaag gcttatgaaa gctgccttgg gtggatggag cttcaattgc 2820
acatggccta ctgttgttgc agctgagggg ccccaaaagc agcttacccc aggctcagta 2880
cctcaggggc cacaggaatc actgggtaaa tctcatccta ctttcaggga gagaggaaca 2940
aggctctggt tgtcctagca gttcctcctt aattcaatat gttacattct ttaggagagc 3000
caggagccag gcccaggctg tttcaggcag ttcctccctg cctcaggata tgggcattcc 3060
cacacactct acagttgttc ttcagactac aagcaagaaa tggaggagaa ctgggtcagt 3120
gcctggccac ttggagaaca gttctgcaga aagaagtcac acctgtgaaa actgcctgcc 3180
aagaggaaac aactacattg acatgtatgt gagcaagaaa tcaattgcta tttggttaag 3240
ccattgaaac tttctatttt tctttctttt tttttttctt ttttttgaga aagggtatca 3300
ctgtagctca ggttgtagta cagtggcatg ttaatggctt actgcagcct tgacctccca 3360
gatccaagca atccttttga gtatctagaa ccacaggtgc acactaccat gcccagctaa 3420
attttaaact ctctaaagag acagggtctc cctatgtggc ccaggcttgt ctcaaacttt 3480
taggctcagg tgatccttcc acctctcgac atcccatagt gctgggatta caggagtgag 3540
ccgtcttccc tggcctgaaa cttttacata tatttgttac agcagttgac actactctaa 3600
gcaggatata taccttgcat gttcaataaa gaatatata 3639
<210> 157
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 157
tatataatta ttgggagtct ctgtgagcct actctgactc agaaagccgc tcctaaagaa 60
gaaaaaagaa caaacaaaca aataaaaaac ccgaattatt tttaaaactc tttattttgg 120
atttttcagt ttctacattt tgttactgta gattttacta gattgaacag ccttatccat 180
aaatatttgc atcaatctct aaattttttt cttcaacact aacttttata gttggaattt 240
tgggggcaaa taatacaaca ttttaaaggc acttgccatg tgtacatggc caaatgcttc 300
cagaaacatt tccacttcca ttagcaaagt atataactac agagtattta aggttttatt 360
cctttatatt tttttctttg gcaaaattgt ctatagtaga aagaatgaat aataaataac 420
ctaaaaaata aaagttctcc ctctgaggac agcagagaaa tttttagctt agcttaataa 480
tacctccttc tccttaggag mataaagagc agtttcgagg agcagaagat gtggtgaaat 540
ataatgttta gtctgatggt ggatgcaaga tccaggcagg ggtggagcat gaccagctgc 600
acagacctct gttcccttgc ttcctctaca tctctcccca cctccatctg cagaccttgt 660
tctcagaggc cattcccaga cccacagcag ctggtatgat ggctgcaggc ctcatgctcc 720
tttgttttgg gagaaactgt tgaggagtta gtatttactg agcagctaat atgttccagt 780
cactattatt cctcataata attagttatt aactaataca tgaaaatttt aaacttaaag 840
cattccaata attttaaaag taaaggaagc aaaaggccaa agcgtccttt cactcactta 900
acctccaatt ttcagtttag catccatcat tttagacttt ttcaggcatt tacatatata 960
gttatgcaga aatgtatagc tttgcttttg tttttcaatt g 1001
<210> 158
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 158
ttaaaagtaa aggaagcaaa aggccaaagc gtcctttcac tcacttaacc tccaattttc 60
agtttagcat ccatcatttt agactttttc aggcatttac atatatagtt atgcagaaat 120
gtatagcttt gcttttgttt ttcaattgaa tcattagtat agttctgcaa ggtgcttttt 180
aatcacttag tatatctcca ttatccaggc tagtgacatt aaatcactct ttttaactgc 240
tgcattgaat ttcctcctag ggatgagcca tcattcctct aaccagtctc ttgtgagtgg 300
ctggttcagt tggtaaccac ttttatactt taaaaatagt gctgcagtgt cattcccaca 360
gaggcttctc tctgcaccca tgcgagtact tcgctgaagt aaccatcagg aagtggaatt 420
gctgggccaa ttgtgaacat tctaagtctc atactcgata tttttgagta actaaagttg 480
aaatggtttt gtcccatgac ygagatcatc aagcttgtga cttgtagagc ctttacctat 540
tgtctaccct ctttgtgttc ctaactctac catagtgggt ccagcccatt gtgggtgctc 600
agtaaatatt tgttgaataa ctttatgaag ggaagaaaga aaagatgagt aaagcctggt 660
cttattcaaa gctctcctaa tcaatatctt tgtgattaaa cgtggtgggt tcagcccctg 720
actgacttca gagcctctgc caggcagtct gcctggatcc caccaggagc caccaggcca 780
taagttgact gtagtaatgg ccaagagttt gacgcttgag gagtccatag tgttggacac 840
ccacagagct gaacaagggt gggaccaggg aatccagtga agagggtcct tcatgaatca 900
gagggggatg atggaagctt ggacctggca agggaagtgt ggggaagtga taggattatg 960
aatattttaa tattttaatg cagtagagtc agagatgtcc t 1001
<210> 159
<211> 1263
<212> DNA
<213> Homo sapiens
<400> 159
agaactcctt tcctctggcc accagagata taagcgaagt gaaggacgag ggataggaag 60
cataagaaac catctcttca gtgactggta cacagtcatt ttggtttagt tgtgtaacag 120
atggcttctg ttgtgtctcc aagtgcacac taccatgggt cctgggaggt ggaatagtga 180
ctgtatctgc tgccagtgtt ytccaactag ccatccccag gaatactcct gtagtagaac 240
tagctgtatt tcttacgtgt tgcagtgagg aagaacacac atcatgggga gctgtggcgg 300
ggtctcagta agaaggtgtt agagcagact tggtatacaa tttgggcttg tgttagggga 360
ttggggccgg gggagttcat agacttagcc ctctgctctg gatgagattc catcaggaag 420
gtgtgggcag gttaattctg agtgagagcc ttaatcaatc ttatgtagga agaaggagac 480
cagggtgaga caaaagctgt aattgatgaa ggggcagcaa tccctcattg ctgagggggg 540
atgtttggtc actgctgtgg tttggacaat gttcatgttt ttctctatgc tcacatatga 600
tgtggggtgg tattgttttt cccatgatcc atcatagtca caaagtgcca ttgtctgtgt 660
tctgtgaaat tgcttatgtt caacaggatg acacagagac ccggtgtcag tttccatatg 720
ttgggacagc ttttctcttt ctcagtgcaa tcccttgccc tgtggctgct ggttaggttt 780
ggtttaaggg gatctctagc agacaatcat aggaggaaga gaaaaggaag aagtctgggt 840
gcttattcac tggcttcctt actgcaagtt accctcaggc tggctgcatt gccttgctga 900
aggtaacagc tcctctaaag gaagtcctca atgcatgaat ctcttctttt ttgtgttcaa 960
aacagcttcc tctcctcctc cctctggtaa ttggggtggg tgggaatagc cccactgttt 1020
ctgaccctgg gatactgcac tagcaaattt agttttcccc tcatcatgac cacacttttg 1080
taaacagctc ctgaatgaaa tatctcttga attatcaaat ctgagcctga cattgattcc 1140
cattgagacc ctccctaata caggagctat ccagaattta ggccaaatta tccttccaca 1200
gcactgggtt ctaatcttca cgtcgaagtg aagggttatg aggatggagg gatccatctg 1260
gag 1263
<210> 160
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 160
tacacttcaa aaggaagagg gaagagaagg atgaggtgca ttttctatgg caggaaactt 60
acttgttgtt tcccataatc tagaggctgt tgaaaggaaa acaagaatgg aagatttaag 120
aaataagaaa atcagaaaag agagagggag ggagaaaagt gtgtctaata aagaggagta 180
gctacagtgg ctcagttggt acagatagat cataactgct ttcaaaaact agtccctgaa 240
attgctcatt aaatttccca aattcttttt agagcaaggt acgaaatgat acagattgag 300
aaggatgaat cttgtactcc taggcataca catatagaca tggtgacacc tatgcccagg 360
tacacattca aaacagatga gctggacccc attgggaagg aactctcaca gtgcctgccc 420
tgccactagc gttcaaccga tgttcccaga cttgatatta agaagaggtg aagaaagaat 480
tgtacctgaa gatggagacc rtggggaagg gtgggatggt aaaaaaaaaa aaaaaaaaaa 540
aaaaaaaaaa aaaaaaaaag actagatgga tgcaaaaaga aggggaaggg gccaacacag 600
aaaaggcaga gttctggtga cacctctacc tttctttcat tgtaggtgga gaggagtctt 660
cgtccgatac caataagtca gcctgatgct ctgtaagttt gctgggtcac atgccctgaa 720
tatttcaact ttttctccac tgtgacccgt ggatgttctc agctggatta attagatcta 780
atctaaagac tcaatttctg tgtggtgggg gttcacctcc gcttttctgg agcctctgag 840
aaactcctga tcctgcacac ccccttgtaa agcctggcca tgcatcctgc accccccatg 900
acacagggag ccaagcctga catttttgag aaggtgccac ctctgatcca tcagagctgt 960
agaggaggga agctggaccc tggaagagac tctaaagaaa a 1001
<210> 161
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 161
agtgtgcata tggtgaatgc ttattacagg aaattcatga gaaatgcaca tgttatagac 60
tagagaatga agtgtacctg ccaatatgag tggatttatt ttatctagca ccaagagtag 120
caaactgagt aataattctc agtcatgatc ctgtggttgt agtgtatact ctgattcaac 180
ttagtttcac tcctgactga gaagctggga ctctgcattt gatggcaatg gagtgggctg 240
atttctttcc aaataagttg aggtgggact cctggtagag taagagggct ttaatagggt 300
atgtctgggt gcctaaaagc tttctctctc tttttttttt tcagagacag ggtctctcta 360
tgttgctcag gctggccttg agctcctggg ctcaagcgat cctcccgcct cagcctccca 420
aagtactggg attacaggca tgagccacca cgccctgccc taaaaatgtt caaaagtcgt 480
atttacagct actctcaaat yccttttttt ttgtgattcc ttataaaacc tttctccctg 540
catttatctt gttatattac agtagaatta tgaggggaaa atcctttggt ggaagtctag 600
ggacatgctc agttcccagg aggcttaatg tgaattttag tgaattgctt aagatccagt 660
attagatctg ctggtccctg cccacccccc ttttattttt tgagacaggg tctcactttg 720
tcacccaggc tggagtgtag tggcatgatc ctgtctcact gtagcctcca tcttctgggc 780
tcaagcaatc ctcccacctc agtttcctga gtagctggga ccgcaggcat gcaccatcac 840
gcccagctaa tttttaaaat attttttgta gagatgaggt ctcactgtgt tgcccaggct 900
gctctcgaac tcccgttctc aagcgatcca cccaccttgg cctcccaaag tgctgagatt 960
acagccacgg tgctcggctc ccatcttgaa atcaatacct g 1001
<210> 162
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 162
taaacgttac tgaacttgct tcttcccgac tacattaaag cacttacttg agatattaaa 60
cattttctca ttagtcctgt ttgcctagtc agtcacttgt atagacaggg caacagcacg 120
gcctgaatat tgggcaggac accgccctgc gcgatagtaa ctttgcccaa cagcttgttg 180
agcttctcgt cgtggatggc gagctgcagg cgtcgggggg tgacgcgggt cttcttgtct 240
cgggccgcgt tgcccgccaa ctccaggatc ttggcggtca ggtactccag caccgcctcc 300
aggtacaccg gcgcaccggc ccggacccgc ttggcgtagt tgcccttgcg gaggaggcgg 360
tgcactcggc ccacagaaaa ctggagacca gccctggaag agtgcgtttt agccttggcg 420
cgagctttgc tgccctgcat tccacatcca gacgcagtga agtatttaaa tacttgttta 480
gaagaaggaa agtgattgat yctagtaaaa cgcaagagct aaactcttat aatctatatt 540
cggcaaagta gactgtgcta tctcctgaac acagatttca gccaatcgaa aagcaggtgt 600
ttaaaaaaat ttaaaaaaaa aaaaaaaaaa aaaaccactt ctgacttaca tacttatagt 660
tgaaaggtca aattatgcaa ggttgagctt ctgggagagc cgatgagatt taggagttca 720
gaaatggcct atcatatatt cagacactaa aagaaccaat gagaaaccga aactcagcca 780
gcctcatttg catatacacg aggtaaataa tgagggcgtt tgggctcacc agcattttcc 840
tgtggtcatt tgacggtatc acttcggctg cgaacatgcc tgaaccagct aagtcagctc 900
ccgccccgaa gaagggctcc aagaaggcgg tgaccaaggc acagaagaag gatggcaaga 960
agcgcaagcg cagccgcaag gagagctatt ccgtgtacgt g 1001
<210> 163
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 163
gacctcagct cactgcaacc tctccctcct gggttcaagc aattctcctg cctcagcctc 60
ccgagtagct ggagctacag gcacccacca ccacacctgg ctaatttttg tatttttagt 120
agagacgggg tttcaccata ttggccaggc tggtctcgaa ctcctgacct tgtgatccgc 180
ccaccttggc ctcccaaagt gctcggattg caggcgtggg ccaccgcgcc cggcctcctt 240
ggacttttta tctgcattgc aggcactcag tggtccaggc cacctacttc tgctctacct 300
ttggacatcc tggcaatgtg ctgctcctca gcctgaccac aacacctgca gtgtcccaaa 360
catatcatgc agtttcatgc ctctgcaccc atttcctctc cctggtcaac acacctgggt 420
gacccctatt ctactcactc agacaaacca ggacaggatc cttgaccttt ctgcaactct 480
atttttctca cctagaaata raattaatga catctacttc tttagcagat gtttaggaat 540
gagatacggt gtggagagca cctggtgcga acacagcgcg tatctgtgat agtgaccgtt 600
agccgttatc ctcatcacca catcctttcc ccacatctca gatggtgcca cagtctacca 660
cctcagagag aaaatagaaa agggaggtcc caaacttcct gctccaccac ctatacctgt 720
ccctcatgat ctgtttcctc tgatttcaac aagcaggtgt tctttctcct gtctcaggct 780
aattctgcac ccacatcggg gagcccccac cccagcttcc ctcaggcttc tctatttggt 840
caattcatta attcattcat ttgacaagga tccatgaacg ctaactatgt gccagtcact 900
attctaggtg gtggagtcac agaagtgaac aaaacagaaa gttctcattc aaaaacaaca 960
taacttgtgg taggaggcag acaggaaatg aaataattag t 1001
<210> 164
<211> 1637
<212> DNA
<213> Homo sapiens
<400> 164
catttctttt tgaaggggtc ttgctctgtt gttcaggcta gagtacattg gagtgatcat 60
agctcactgc agcctaattt tttttttttt tgaaagacag agatcttgct atgcatactg 120
cccaggttct tgaactcctg gcctcatgca attctcctcc ctcgatcttt caaggtcctg 180
tgattacacc tgtaagccct cgttcccggt tggaagttac agtttaaaat agggtggtta 240
tgagcaaggg gagcgaggca cagaatactt gggagaaaag cattccgagt tgagagaaca 300
gcagtgccag agcacagagg cagaagcact gtggtttgtg tgaagaaaag caatgaggct 360
ggggtgcgca gagcacacag ggtgatcagg agaagaggag gtgacaaggc cagagggggt 420
tgagggccag atcatgtatg gccttgaaag tcatcatgct gacctgggct ttacctctga 480
gaggggagcc actggaaggt tagagcagaa aaaggactgg actgacttat gttttaagaa 540
gttacttcac atgctagacc aagatgggct gtgggtaggg gtggtggatg gaggcctgaa 600
gacccagctg ggagctactg cagtgatcca ggggaaagat gcagatgact tgtaccaggg 660
aggagccatg aaaatgttat gatgctggat ttattttcaa gatagaataa aaaggctttg 720
ctgataaact tacaggtggg gtgtgaaaaa ggagggcatc aagggtgacc acaaggtttt 780
ggtcctaaga aacggtacag atggagttgc cacttactga gatggggaaa atgagggaga 840
aaccgcttgt ggaggccaga ggaggagcca gcacagaatc caaaggtcag ttttgaatat 900
gttgggtttg aggagcttac tagagattcc cgtggagatg tagagtaggc aggtcaataa 960
taagcttgca gtccaggcaa cgggtcaggg ctggaaacac aagttattct ctttgtcttc 1020
tttatattca tgtttgttgc cactgtgtgt ttcacttacc taaygcattc gtgatttatt 1080
gctgcataac aaattaccac aaacttagtg gtttaaaaca gtacactttt ccagcctggg 1140
caacatgatg aaaccccatc tctactgaaa acgcaaaaaa taaaagataa aaaattagcc 1200
cagcgtggtg gcacacacct ataatccccg ctacttggta ggctgaggca caagaattgc 1260
tagaacccag gaagtggagg ttgcagtgag ccaagattgt gccactgcac tccagcctgg 1320
gcaacacagc gagactctgc ctcaaaaata aataaataaa taacagtaca cttttatcac 1380
ttcagtttct gtgggtcaga agtccaggca gagcttagtg ggcttctctg ctcagaactt 1440
cacaaagcaa aagtattatt catgcatgta aacctctaag cacaatacca acatcacggt 1500
aggttctatg tgagtataag ctattattaa gaataataat caatcctctt ccctctcctc 1560
catccctaag gcctcatcat ttcttgcctg gagtgtcaca gtagctttct tcctggtctc 1620
cttgtcttct accatct 1637
<210> 165
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 165
cctatcttgc tgctgcttct cgccggagcc agttacttct tgtggagaca acagaaggaa 60
ataactgctc tgtccagtga gatagaaagt gagcaagaga tgaaagaaat gggatatgct 120
gcaacagagc gggaaataag cctaagaggt atccaacgca agcagagaat ctaagctctt 180
ggcttgcatg ccccagcctg aaaacctcac ctctctcccc taccctggca ctgcatcatg 240
tttaaggttt atttcccgaa acaccaacct cacccataac agttcatctt tttttttttt 300
tttttttttt tttggttatt ttccagagag cctccaggag gaactcagta agttaccatt 360
cccccagaga tccagacatg tcttcctatc ctcgctttga gcaccttgat gactcttccc 420
tgttcattcc attgcagaga ggaaaaaaat ccagtacttg actcgtgagt ggctttgaca 480
ttttctctga attcaaatct rttactctct ctctgcttca ttattttcca gcccataagt 540
catagcccag ggttgaaaag tggtcttgga tccctttacc cagaaaaaga aaacaagtgt 600
ggctctttgg agaaaccacc cagtgctttt tctctctaga aaaaaaaaaa aaaaaaaaag 660
aggtcttcaa tctctttgta ctaggggcta cagaccctta agctctaaaa agcactgagg 720
aatatccagg ggtacacttc aaaaggaaga gggaagagaa ggatgaggtg cattttctat 780
ggcaggaaac ttacttgttg tttcccataa tctagaggct gttgaaagga aaacaagaat 840
ggaagattta agaaataaga aaatcagaaa agagagaggg agggagaaaa gtgtgtctaa 900
taaagaggag tagctacagt ggctcagttg gtacagatag atcataactg ctttcaaaaa 960
ctagtccctg aaattgctca ttaaatttcc caaattcttt t 1001
<210> 166
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 166
aactgctctg tccagtgaga tagaaagtga gcaagagatg aaagaaatgg gatatgctgc 60
aacagagcgg gaaataagcc taagaggtat ccaacgcaag cagagaatct aagctcttgg 120
cttgcatgcc ccagcctgaa aacctcacct ctctccccta ccctggcact gcatcatgtt 180
taaggtttat ttcccgaaac accaacctca cccataacag ttcatctttt tttttttttt 240
tttttttttt tggttatttt ccagagagcc tccaggagga actcagtaag ttaccattcc 300
cccagagatc cagacatgtc ttcctatcct cgctttgagc accttgatga ctcttccctg 360
ttcattccat tgcagagagg aaaaaaatcc agtacttgac tcgtgagtgg ctttgacatt 420
ttctctgaat tcaaatctgt tactctctct ctgcttcatt attttccagc ccataagtca 480
tagcccaggg ttgaaaagtg ktcttggatc cctttaccca gaaaaagaaa acaagtgtgg 540
ctctttggag aaaccaccca gtgctttttc tctctagaaa aaaaaaaaaa aaaaaaagag 600
gtcttcaatc tctttgtact aggggctaca gacccttaag ctctaaaaag cactgaggaa 660
tatccagggg tacacttcaa aaggaagagg gaagagaagg atgaggtgca ttttctatgg 720
caggaaactt acttgttgtt tcccataatc tagaggctgt tgaaaggaaa acaagaatgg 780
aagatttaag aaataagaaa atcagaaaag agagagggag ggagaaaagt gtgtctaata 840
aagaggagta gctacagtgg ctcagttggt acagatagat cataactgct ttcaaaaact 900
agtccctgaa attgctcatt aaatttccca aattcttttt agagcaaggt acgaaatgat 960
acagattgag aaggatgaat cttgtactcc taggcataca c 1001
<210> 167
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 167
gaaccaccta gtcttcaggt ttgcctggtg ctcaccagct gaagaaatcc tttaacgacc 60
tttattcagt caagtaaatt gttttctttt ggcaacttgc atgttatttt ttaggttttc 120
atttatttat ttttttatat ttaaagtcat attttcttcc ttttattcac tttgctggtc 180
tttctcactt tgattttttt ttgccttgtt ttgcatttgt ttactttaac attttttgta 240
acttatctct tttattttgg aaattattca cattatcagt tttcttttgc taggcaattt 300
tgatattcta ataaacatta ttaacataaa atataaagtt tactaacacc aagcccaaac 360
aatacaaagt cttagggctc tttaattgca attatttaaa aatatttgct acaaattgtt 420
cattatttta tatttacgtt gtttttctta ttcccacaaa tcacatattg ttggtgtgtt 480
tgttaaataa aaatctttaa ytgcaattgt ttaaaaatat ttgctacaaa ttgtttgtta 540
ttttatattt acgttgtttt tcttattccc acaaatcaca tattgttggt gtgcttgtta 600
aataaaattg tgattgctta tatatatttt ttcacatcct ttcttcttgt aatattttgg 660
aatttacatc cagttaatta tcctttattc tatagtatat actgtaaaag ttactagtct 720
tgctagtaaa ccctcagttt ttggattgtc tgaagatgtc tctattttga tctgctcttg 780
aattctaaat ctaattgaca taaaattcta gatttgccat tatcatttat tagcctttca 840
aagatattcc acaattttct gactttcaat atttttgttg gtaaaaatgg ggattgttaa 900
tcggcttgca tattctgttt tggatattcc attgtttcct tataatttgt ttatttataa 960
ggaaacttat aaacaaatta taaggaaaca atagaatatc c 1001
<210> 168
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 168
agccgggggg tgcggagatt gcagtgagcc aagatcgcgc cactgtactg cagcctgggt 60
gatagagcga gaatccgtct caaaaaaaaa aaaaaaaaaa aaaaaaaaag tgggaagcaa 120
ccagtggaaa gcaatggtaa gagcctgaca aatctcataa aatctcccat tatttttttc 180
ttggtgcaag aaaaaagcaa gtcattaaaa aggaagagaa tgtcgtggtg actgtgatgg 240
gcctactttg tacttttcac tgctctgggg tgttcttgcc tgtctaaaag aattttgaca 300
aacgtgatac ctaccacaat tttttcagtg gacatctaac gtttttcatt aagtttaaat 360
ttttctgaag gatatagtga cttgtatcat aggaatctaa aaaccacagt aatttaatac 420
ttaccagcaa ccttttaaaa gagagaggtg aacattgcta cctctttaat tgtggaagat 480
tttacattga tcctttattt ytctgcattc atagtgccat tgcctgtctc ttatagaatt 540
tttatcccag tacaatgtca ttttgtagtt ttttcttgat ctttctatga tacttctttg 600
gaccaaatat aggtataaat attgaagtcc attgttattt cctgttaccc aaaatgtgtg 660
ttaaaaatag tttttctgga ttgtgttata tttgcatcta ctgctagtac ataatcaaaa 720
cataataggt aaataacaat tttaaagccc ctttactgaa aggtgtaatg gaagtcaatg 780
tggaatttgt catccccttt cctccaagaa attgtacaca atatgcaagt ccacctcgat 840
ggatggaggc tctaacttag tattcccaat tgtttccatg ttgggagctc gagaggagag 900
aatttttagg cctggagcaa tgtgtcatag gcaaacaact accagaaatt tatcaagtga 960
tatctttcca tggagtgcca tcactgattt gattatcaga c 1001
<210> 169
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 169
agataagcaa aggaagagtc aggaagcaaa gagggcaggg catgagcatg gaaaaagcgc 60
caatgtttag gggtttatgt gtaggaaaag ttatctaatg ccaaaagaga gcgtttaatc 120
tccctttaaa gaggtggcca aagatagact gtccacgagg ggaattcttc attttagagt 180
cataacagca agccaagggc aaaagagaca gatctcactt atctgtgaat gcagaaaaca 240
aaacacgtcc tttaatgtca acgtcttgag ttctttttcc caggttgact gactaaatat 300
ctcagtacag atacttttgc ccccttccaa aacgcaacca cccatgaccc cgacgtgatt 360
tgaacacgca accttctgat ctggagtcag acgcgctacc gttgcgccac gaggtcacgg 420
agaccctcca ttttcctttt aagataagta tctaatctta tcctcctccc aaacaatttc 480
tttattattt gatttgatct yttttcacag ttttgctaag gcttttttga gaaaaataag 540
ggagtggctg gattaaatat taaccccaaa cccaaataaa tgctccatat atgaaaaaca 600
gtggtttctc aagttcaatc tttctatttc tcgaatttct ctgtttcgag aaaaagtgtc 660
tatgtgttgg gtttagatta gcagtgaaac agtaataaga acggttatga agtttgtact 720
actactttct gtaaatgcgc tagactactc cctcttcagg aagagaattc cagcattgca 780
ctgccccgca agacctggcc tagctagcac ttacttcact caaacccatc cgcacacccg 840
ccccatcctc aacctaatgg gattcgaaag cctaacataa ataatatctc tagcctaaac 900
gttcacttct cagtccaaat tcgcgggccc tctggtctct attgtgtaca caagccattc 960
agttcacaac aataacccca aagaatccgt taacatttac t 1001
<210> 170
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 170
gctgttggat gccaaatgta atagtctaat catgactctg aataaatgtg tctctttgaa 60
aaatgtgcta tgtaaagtta gtctactctg aagccatctt ggtaaatttc cccaacattg 120
tgaagggaat tccttcaggg tgatgccaca ttctatttgg aatttgtata tgacctgctt 180
gggtggagaa gccattatct tcagtaacct tggtgtagtt gaactgatag ttactgttgt 240
gacttgaagt tcaccattaa aagagttcac cgggccaggc gcggcggctc acatttgtaa 300
ttccagcact ttagaaggct gaggcaggag aattgcttga acccagaagg cagaggttac 360
agtgaggaga gatcttgtca ttgcgctcca gcctgggcga cagagtgaga ctccaactca 420
aaaaaaaaaa aaaaattagg ctcaaggatt ccagaaataa catggaagta gatatctggc 480
tatttgactt tcattctggg mtgggggtag ggggttcttt acagcctggg gcaatgaaag 540
tctcagctcc ctgttctgct ttcttcgaga agtgtgtgtg tgtgtgtgtg tgtgtgtgtg 600
tgtgtgtgtg tgtgtgtgtg ttggaggtag agggaatgca ccttgttaca gcttgatgga 660
agtctagatt ccccactttg cctttgctgt tgtgtgtgaa ggtttggacg acagttgttt 720
tttttttttt tttcctcttc cagcttccca agagcagaag tccgtagaaa tggagtttgt 780
aactccactg aacacacaaa attagctaaa aaaaaataac aagtcacaaa acaaaaattt 840
taaaaatgta aaacttttag aagtagagtc aggcttcggc cgggcgcggt ggctcacgcc 900
tgtaatccca gcactttggg aggccgaggt gggcggatca cgaggtcagg aaatagagac 960
catcctggct aactcggcta actcggtgaa accccgtctc t 1001
<210> 171
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 171
cacttggttt aattttctga acaatgcaat ggttgatcaa accaatttaa ccaataaagc 60
acatgtccag ttctcctttt tacgtttgta actcgccagt tcctttagca gaatgtccag 120
atgctctata gaaatgaaat gaaatgaaaa aaacaaaaac aaaaaaccaa aaaacaaaga 180
actctaaatg tggatgccag atcccaagat gcatagatgt acagatccca ctttatggtc 240
agaaaaatgt taatcgacaa aatgaatttg atgcatcttg agaaagctaa ttgtttggtt 300
ttaatatatt atatttaacc ggaagtaaca aagtgccttt tacatagcat tctatttaat 360
tcatatatca cggagaaagt ttttttccag aaaactgaat ctttttcaaa atcaaataat 420
ttccttttat ctgtacctag agaaagttaa ttatgtcatg actgataaac agaataaatg 480
tggtcatgga aagtaagaat rcatcacact tactttctat atatagatgt ttatatcgaa 540
caagagcatt actaatgtgt tttttattgg ccatctttgg aaaacgtgca gtcatttgct 600
ttaaaagatt gtataatgta ttttaaatct ttattttcag ctgggcgcgg tggctcacac 660
ctgtaatccc agcactttgg gaggccgagg cggatagatc acctgaggtt aggagttcca 720
gaccagcctg accaatatga tgaaaccctg tctctactaa aaatacaaaa attagctggg 780
cgtggtggca tatgcctgta atcccagcta ctccggaggc tgagacagga ggattacttg 840
aactcgggag gcggagattg cagtgagccg agactgagcc attgcactcc agccacttca 900
gcctgggcaa ctagagtaaa attccttctc aaaaataaat acataaataa atatttattt 960
attttctgcc tgtcccttta ggactatttt tggagcaggc c 1001
<210> 172
<211> 626
<212> DNA
<213> Homo sapiens
<400> 172
agactacttg tgattcatgt caaaacaaag tttaatcaag ccatatttaa agagacccta 60
caaatcataa gagaaagacc taacaactaa gtagaaaaat tagcacagaa tactatgcat 120
gtaacagaaa aggaaataca aatggctttt aaacatataa aaaggtgctc aaggacaata 180
taaccagtta aatgcaaaat aaaactccct gagggatcat tttcacattt caaactggaa 240
aaaacaagat aaactctgtt gagaaggact caaccatgct cttcagagtg tgtgagagac 300
agccctagct aagggttggg cttttcttgt acaatcattt ggaaactatg aaaatcctgg 360
ggagtggctc ttatttcctg ggaggtacct agaactagag tttcttacct gtggccttcc 420
ggtcaratag cctcagaggt tcagttcctg gtggaattga aaatcctgga gtaggccatg 480
gatgtgagcg gtggatatga gggatttttc cttctattgg caatctgata ggttgtggta 540
gagaatcatt cacacactac tgcctgttga ggcgatttct ttagatttga agacaaaaaa 600
acgtcagtgt taacgcaaag gggtag 626
<210> 173
<211> 656
<212> DNA
<213> Homo sapiens
<400> 173
ggctgtatct cacttttaga tatgtcttca gcatgttcct tctcctttct ccaaatgttt 60
gcgtaactcc tttcttactc atatcttatt tggaaaggca tatcttactt gggaagagga 120
ggtgacaatt ctcatgttta cttccaacaa attacctatc ttccagtgaa tagaaaatac 180
actgaggttg aatataattt tatattttct tgcactcgaa ggcaaaacac tgttactgac 240
ttttgcctga gaccattggt tattgtaaat cgttattgtc tttttgcttc tacgggagcc 300
tcctgcttct tttgctcttt tgttcatctc tatgcatgat ttattaaatt catttcgtgt 360
actgtgaatt cttctctaaa gctatctgtt acgatggcca aaagacatca tttataccct 420
cctccttcca tacttacaga aactagacac atggartgtt atgagaaaga gaagcaacaa 480
tgaagttaag tgtaaaatgg ttgattctac ttggatagat ttttttaaaa aatgtaaatg 540
gtagaaaaca taggggtaca tttaaagcat tttgtgaatc agaattccat gggcaaactc 600
agaagaccaa taatctttat tttgtctgct taccttctag aagcatttta actaac 656
<210> 174
<211> 101
<212> DNA
<213> Homo sapiens
<400> 174
actgcctggc ttggaaaagt taagaagccc ctcaggaaga gaatcgaggc yaagttcctc 60
tgcgccgagg gccccgagca tatccgccaa ggctcagctg c 101
<210> 175
<211> 51
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (26)..(26)
<223> n is a, c, g, or t
<400> 175
ggtttttttt tgtttttttt ttgttntgtt tttttcctcc ttgcttggca a 51
<210> 176
<211> 1168
<212> DNA
<213> Homo sapiens
<400> 176
cactttccag aaggaaggtc cctctggtgc aggctcacta ctaggtggca ctgtgcacta 60
ctgggctagt tctggtaaaa tacccctgcc ccagctaaag tctctccttc cctccctccc 120
tccttccctc cttctctcgc tccctccctc cttccttccc tccttctctc cctccctccc 180
tccttccttc ccctcctctt cttccttcct tcctcccttc ctttctctct ctctctttct 240
ctctcccttt cttcccttct ttcttttttt ttgagacgga gtttccctct tgttccccag 300
gctggagtgc aatagcgcaa tcttggctca ctgtaacctt cacctcccgc gttcaagcaa 360
ttctccttcc tcagcctcct gagtagctgg aattacaggt gcccaccacc atgcccagct 420
aatttttgta tttttagtag agacggagtt tcaccatgtt ggccaggctg gtctcgaact 480
cctgacctca ggtgatctgc ctgcttctgc ctcccaaagt gctgggatta caggcatgag 540
ccaccacgcc tggcctcttt cttttccttt catttccttt cctttctctt tctctctctt 600
tccttccttc cttccttctt tcttttctct tttccwcttt attttctttt aaattttaat 660
ttaatttaat ttaatttaca gagatggaga ctctctatgt tgcccaggct ggtttcaaac 720
tcctgggctc aagtgatcct cccacctcag cctcccaaag tgctaggata acagccatga 780
gccacggtgc ctggccagag cttcagtttc tatggacagg tgttttcggg cttgctaaat 840
caaaattctc cagaattcct aagatcagcc aattttaaga gcagtaattt tttttttaac 900
agtcttgctc tgtcacccag cttggagtgc agtgatgtga tctcagctca ctgcaacctc 960
tgcctcccgg gttcaagcaa ttctcgtgcc tcagcttccc aagtagctgg gattacagcc 1020
acgcaccacc acgcccagct aatttttgta tttttggtag agatgggtct caccatattg 1080
gccaggctgg tctcaaattc aagctgtctg cccatcttgg cccccagagt gctgggatta 1140
caggcgtgag ccaccatgcc cggcctga 1168
<210> 177
<211> 701
<212> DNA
<213> Homo sapiens
<400> 177
atgtggaaga aaggtggtcg aaaatgaaat ttacaggtga gttcctaaaa ggcctaccct 60
tccccatgtt gagttaagtg tcaaaacatt tctagggaga tgactgtggt aaacccgcgg 120
ggcggtcaga ggcatgcctg agagggggcc gtgagaactc agcagaaagc tgggggagtg 180
ctgtctgttt caggttgagc rccatgtgtt agcttggtgg gagaagaggg ggcatgagca 240
ttggttttaa tgtgtaaaac ctccggataa attttttttt tttttttgag atggactctt 300
gctctgtcgc caggccagag tgcagaggcg caatctcggc tcactgcaac ctctgcctcc 360
caggttcaag tgattctcct gcctcagcct cctgagtagc tgggactata ggcacgtgcc 420
agcacgcccg gctaattttt gtagttttag tagagagggg gtttcaccat attggccaga 480
atggtttcca tctcttgacc tcatgatctg cctgccttgg cctcccaaag tgctgggatt 540
acaggcatga gccaccacgt cctgccctct taggatgaat ttttacaaat taagttttta 600
ttttaccaaa ttgattttta aacattcccc tttattcatt ttatttttat ttcatttttt 660
tcattttatt tttatttatt ttttgtttgt ttgtttgagg t 701
<210> 178
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 178
ataaagaatc aacaaggttt gtccagctgt cttgagcaat cccactgatc tgctcaggaa 60
ataccacatt tcactcatta gatgtggctc aatcgatcaa gccactcagg cctgatttga 120
ggctccagtt cacagtgaaa tggtccctgc actcttccat cacccttcaa taggtcaact 180
cacctccttc cctgtcagtc aacacaagag agtgagctcg gccgcaggag acctgcagca 240
cccgtgtctc ctgaggtctg tccagaggca gggagacggg tgagggctcc aacacatact 300
cgtagcccct cgctggaaaa gacacaggac actgattgag gcatgcattt ctaccactgg 360
aaatcatact gtccaactcc acgctactac actggaaaaa agagagtcgg aggtaggaaa 420
gactcatcaa gacaggtaag ttaggcgcag agcaaggacc agaagcccaa ctcccagccc 480
atggcatggg ctgtctctat yacataatgc gggttccaga aaagcatact tggtcttctg 540
gctgggcgca gtggctcatg cctgtaatcc cagcactttg ggaggccgaa gcgggcagat 600
cacctgaggt caggagttcg agactagcct ggccaaaatg gtgaacccca tctctattta 660
aaatacaaaa attagccggg catggtggcg ggcgcctcta atcccagcta ctcgggaggc 720
tgaggcagaa gaactgcttg aacccggaag gcggaggttg cagtgagctg agattgcgcc 780
attgcacttc agcctggggg acaagagcga gacttcatct ggaaaaaaaa aaaaaatgca 840
tacttcgtct tcttattaaa gaaatcttgg ccgggcagtg gctcatgcct gtaatcccag 900
cgctttggga ggccaaggca ggcggatcac ttgaggtcag gagtttgata cccacctggc 960
caacaaggtg aaacccccgt ctctactaaa aatacaaaat t 1001
<210> 179
<211> 1449
<212> DNA
<213> Homo sapiens
<400> 179
aaccccatct ctactaaaaa taccaaaaaa attagccagg tgtggtggca ggcgcctgtg 60
aacccagcta cttggaaggc tgaagcagga gaatcacttg aacctggaag gcggaggttg 120
cagtgagccg aggttgagcc actgcactct agtccgggca acagagtgag actccatctc 180
aaaaaaaaaa aaaaattaag aaaaaagaca agaggccagg tgcagtggct catgcctgtg 240
gtcccagcac tttgggaggt caaggtgggc ggatcacctg ggatcaggag ttcaagacca 300
gcctcaacat ggagaaaccc cgtctctact gaaaatacaa aaaaaaaaaa aattagctag 360
gcgtggtggt gcatacctgt ggtcccagct actcgggagg ctgaggcagg agaattgctt 420
caatctggga ggtggaggtt gcagtgggcc aagatcgtgc cattgcactc cagcctggac 480
aacaagagca aaactcagtc tcaaaaaaaa aaaaaaaaga caagagaaaa tatttagaca 540
ggtaacgaag ggttttatgc aaatatatca agtactccta caaagtaata agagacaaac 600
aatccagtat gggtgcggtg gtggctcacg cctgtaatcc cagcactttg ggaggctgag 660
acgggcggat cacctgaggt caggagttcg agaccagcct ggccaacatg gtgaaacccc 720
gtctctgcta aaaatactaa aattagccag gcatggtggt gcacgcctgc agtctcaggt 780
acttgggaga ctgggacatg agaatcactt gaacccatca ggcagaggtt gtggtgagcc 840
gagatcggac cactgcactt cagcctgggc gctgggccac agagtgagac tctgtctcaa 900
aaaaaaaaaa aaagagacaa cccaatagaa acgtcaccaa ggatatgagt agatttgcaa 960
ttctcagtag aggagacgtg aaactgtaag atgttcaact yttccagaga ttacagaaat 1020
ataaagtaaa taaaaaatga gatatgtttc aagtagcaga ttggcaaaca tttaaaaaac 1080
gtgggcgggg cacagtggct tatgcctata atcccagcac ttggggaagc tgaggcagga 1140
ggattgcttg agcccaggag ctggagtcca gcctgagcaa catagagaga cccccgtctc 1200
tgcaaaaaat tttagaaatg tccaggtgtg gtgaggtgtg cctgtagtcc tagctacttg 1260
ggaggctgag gtaggagtat cacgagagct ggcaagattg aatctgcaga ggctgcagtg 1320
agctacgatg gcaccactgt actccagcct ggttgataga gtgagacctt gtctgggaaa 1380
aaaaaaacca agtcgtgtag cagggggata tgtaaaagca aatcccactc ataatattga 1440
agcacaact 1449
<210> 180
<211> 501
<212> DNA
<213> Homo sapiens
<400> 180
ggcctctcaa agtgctggga ttacaagcgt gagccactgc gcctggccaa ataattttta 60
aaatttgccg ggtgaggtga tgtgcgcctg tgatcccacc tactcgggag gctgacgtgg 120
gaggcttgct tgagtgcagg aggttgaggc tgcagtgagc tatgactgta ccactgcact 180
ccaacctggg tgacagagca agtccatctc ccctcaacac acatagcaaa aaaaaaaaaa 240
agagagagag wgaaagtggt agaatctggg caaagttaga gctgccggag gaatctgaag 300
gaatggtgtg gagcgtggga ggaataagat gcttccaagg cttctggctt gagtaagtgg 360
aggaatggag tttcattcat tgagctggag aagactgcag gagaagtgtg gggagcgtga 420
gacatgttct tcttgggatg cctattcatt ctccaagata aaaatttttt ttcttaagtc 480
gctgtacaag tggagatttc a 501
<210> 181
<211> 601
<212> DNA
<213> Homo sapiens
<400> 181
ttattattca ctgaacccct tctgtaatcc actctgatgt ctattttaga ctgagcttgg 60
gtgtatgatt gtcatttgta ttagggcctt tactaaattc ctataactgt atcaatcatt 120
cttctcaact actcccccct caaaaaaaat ataggctagg gtatttttat ttaatgattt 180
tattctacta ttgtttgacc tacactatgg agacacagac acactgaaac acatgcatcc 240
atgcatacac acatttgttt taaattctct tccagtttat gtatcagtga ccttgaacaa 300
wgtcacctag attctgtgtt tcagttttct cttctccaaa taaaagaagt tactttacat 360
aaatttgttg ggattcaatg aaatattatt tagaaatgtg ctgtgtgtgg catatatgtc 420
taaaggacag aattaatgga tatatatata tatatatata tatatatata tatatatagg 480
aatgtattaa atactcacat gatcacaagg tcccacaata ggccatctgc aggctgagga 540
gcaaggagaa ccagtccgaa aaactgaagg atttggaatc caatgttcaa gggcaggaag 600
c 601
<210> 182
<211> 549
<212> DNA
<213> Homo sapiens
<400> 182
ggatcaagaa gttgcagtct gtgtcctaat ttccactccc tgccatgggt gcggaacctt 60
gagcagtaga ttgggcccta ttggggacat ctggatggta acacagactc caaaatgcaa 120
gggctaatga cccatcccct agtccgtggg agactgcaag tctctggggc attttgggct 180
ccccgaattg tctctatgtg cccagaccac ttacagcatg atgtctggac acaggattca 240
ggcatcacta tttggaaaaa aagccatctc agtggattcc aatatggcgc caaagtcaag 300
aaccactgct cagcggattc caatatggcr ccaaagtcaa gaaccactgc tctttgagaa 360
gtcagctcaa ggtcacatcc aaggtggcac aggagagaga gggacagagc acagcattgg 420
aggaggcagg tggctagaaa ggtgggctct gaggcagtac tctggccctt tccagaacgt 480
gtgtgtagaa tgcagaaatc ttgaggacca catgttccag gaggagagtg gtgaggaagt 540
ggaagaata 549
<210> 183
<211> 601
<212> DNA
<213> Homo sapiens
<400> 183
gtgccaaaag aagaactcaa aatccctgtc tctcacctga aaatgataca gaagactgga 60
cctaggggtg aggcctctgc aagcggggat tggagaagcc tgacctcaaa tctagaagat 120
cctataattt atattgcata atcacaggtc atagactcag ccacactgtt gggctgtagg 180
aaagcattgg tttacttcca agcaaagagg gatgcctgtg aagagccagc agtccttcca 240
ttcctgattt tcctccttct accaacccac aggaacattc ctaggctgcc ccactctgaa 300
yccagtgttc cttctgtaag aaaggccaga tatgactgtt tattttcagg atgcatgcta 360
acagggccgc caggaaggta tctcagcttt catgccagaa ccaatagagt attccccagc 420
tggaatttag agtgatccag gcctgaaatc tcactttcag caataattaa aattttatta 480
gtgcttcaga atttaagata tgtgtttctc attcaccatt tcatttaatt atcatgacat 540
tatattgtta tcccacttac acagaagata aaactggggt taagagaagt tatgtatcca 600
a 601
<210> 184
<211> 401
<212> DNA
<213> Homo sapiens
<400> 184
cccctatcca caacccacag ggataaacag ggtaaagaaa ggaggaccag agcagaggtg 60
ggtgtggctt cagtagaact cagcttatcc agaaaccaag ctgaaatttc agccacactc 120
tgtgggtttc cccagaattt gtcttctgaa cactctataa atcccagaag actgaagggc 180
ttcctattga atttcagttg ycccattgga ctcaatattt ttattgagaa tttaatattt 240
ttattgggtc caatgggaca actgaaaatc agtatttttg ggatattttg ggaaactcat 300
cagccaaggt cctaaggcct ggccaggtca tgagtccctt ctgattagat gatcgttact 360
cacatcttag agaccattcc cactttagag aggagtaact a 401
<210> 185
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 185
agtcacccaa atgctttgtg aagatccatg tttcttcctc gtgggctgtt cacagttaat 60
ttgtgatccc atcttcatct cactcatccg cccattcact cattcaatgt gtgtgaatgc 120
cctccataaa tttgtactgt gctagtcact gaagtacaga gctgaataaa acaagactgc 180
ttctctcaag gagaggagag gataaaggat ataaacaaat aattattttg gaaaggatct 240
tagtctacct ctccagcttt tactaacacc atgatgaact ctgcccccca ctacagtttc 300
acgctgcgtt tcacactatg ttctgcaagc acctgatgac ttgaagcctc acaaaggcat 360
catcctttgc cttcaagatg tggcctctgt ttctcctttc actactggtg tgctaccctg 420
ccctctcttc ccagttaatt cttactcatc cttctaggct cagctcaggt gtcagtttat 480
ccaaaaggta acaatgatgt mtcctcccca taggttatgt gtccctccca tcagctccca 540
aagaatgtct cagattttcc caacacaccc ttcacacact taacattgta attatctgga 600
tatttttctt tctcgtttac tatattgaga aggctaagag ggaatggagt cacgttacaa 660
ttgttttgga gcctagctca atgcacaacg tacaagtgct caagaaatgt ggaaagaaga 720
aattaactgt ttttgtataa aggagggaga ggtcaattct ggagtaggga atcagagagg 780
gcttcacaga aactattgaa ttgaatcttg aagaattaac gtaaattcac cagatggaca 840
agtttcagaa aaaaactttc caggaaaaac aaacagtaca tacaaaacca aaaagaaaga 900
aaacaaacat tcaaagaaat gtaagtattt aacatgtctg gggtataaat tgcgatgatt 960
aaaatttggc tatgattaag aagttcaccc tcaccaatgt g 1001
<210> 186
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 186
tcacccaaat gctttgtgaa gatccatgtt tcttcctcgt gggctgttca cagttaattt 60
gtgatcccat cttcatctca ctcatccgcc cattcactca ttcaatgtgt gtgaatgccc 120
tccataaatt tgtactgtgc tagtcactga agtacagagc tgaataaaac aagactgctt 180
ctctcaagga gaggagagga taaaggatat aaacaaataa ttattttgga aaggatctta 240
gtctacctct ccagctttta ctaacaccat gatgaactct gccccccact acagtttcac 300
gctgcgtttc acactatgtt ctgcaagcac ctgatgactt gaagcctcac aaaggcatca 360
tcctttgcct tcaagatgtg gcctctgttt ctcctttcac tactggtgtg ctaccctgcc 420
ctctcttccc agttaattct tactcatcct tctaggctca gctcaggtgt cagtttatcc 480
aaaaggtaac aatgatgtct yctccccata ggttatgtgt ccctcccatc agctcccaaa 540
gaatgtctca gattttccca acacaccctt cacacactta acattgtaat tatctggata 600
tttttctttc tcgtttacta tattgagaag gctaagaggg aatggagtca cgttacaatt 660
gttttggagc ctagctcaat gcacaacgta caagtgctca agaaatgtgg aaagaagaaa 720
ttaactgttt ttgtataaag gagggagagg tcaattctgg agtagggaat cagagagggc 780
ttcacagaaa ctattgaatt gaatcttgaa gaattaacgt aaattcacca gatggacaag 840
tttcagaaaa aaactttcca ggaaaaacaa acagtacata caaaaccaaa aagaaagaaa 900
acaaacattc aaagaaatgt aagtatttaa catgtctggg gtataaattg cgatgattaa 960
aatttggcta tgattaagaa gttcaccctc accaatgtga a 1001
<210> 187
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 187
gtatatgtgg aggtggggag acagaaacag agacagagag agagagagag agagaaatac 60
tgagacctag aaagcttgaa taactcattt caagtcaaga gcaacttaat ggtaaacttg 120
gatcaaaaca caaaacacta ttctttttag tcctgtattg tttccactat atcacaatac 180
agtgttcaat agttctcttt aaatcacata ccaggagcta aatttactga agtattacaa 240
aaccaccaaa tgagctttca caggagacct aaaagaggaa attaaagatg caaatagttt 300
aagaaaaatc tgtgtttgat tcagaaactt aaaaccagtt tcttcaaaaa cttgttaaaa 360
gagaaagaaa caggcatttt tacccaaaga aagaaatacc atattctaga gattcactaa 420
ataattttta tgattctcta tgctactttc aagaaactct gacttcagtt atgtagacta 480
aggtgacaag aaccatttat rtaatcaact gtaattacat gaaattctct ctttagcaca 540
tggtacccac tgaatgtggc acaaaagagg atatgatcag ttgattcagg atgatgtcat 600
ttccatgatt ctaaaccaag aatcttcaag aaagcctggg ctgcaagttc cagggtcaaa 660
ttgcagactg cttgcagaga gtggctctgc tattccaaga acctcagatg gctcactgga 720
gtgatctgct ttagatagtg tgatcatatg tcttgaaatt tccatgacag tcttgtttat 780
acatgttgct ccagaatatt tattatagtg ctctctttca caatcagagg tgttccgctt 840
tgaatggtga gttataaaat agttacccta gccatgtgga gtgtgctcgc tcacttaaca 900
ttcaacatgc agtaagccac tttcacacat ggccctgtgc tcacgactta atagaggtta 960
ttaggcaaac ccagcttcac tctgctaaag gtattttatt t 1001
<210> 188
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 188
caatcagagg tgttccgctt tgaatggtga gttataaaat agttacccta gccatgtgga 60
gtgtgctcgc tcacttaaca ttcaacatgc agtaagccac tttcacacat ggccctgtgc 120
tcacgactta atagaggtta ttaggcaaac ccagcttcac tctgctaaag gtattttatt 180
ttaaaattac tcaaagcctg tctgaattcc accctaactc cataacagac attgggtgcc 240
ttcaggaaat tacttagctt ccctctggtt tattcatgtt tactatgaaa tgggaataat 300
tgcatcagtc ttaccacacc aggtaataaa taatggtcga ggaagtaatt aggcttagaa 360
gctggataga aactaagatg cctaagtact aattaggaat acagctgagt agattgtggt 420
tgatggccgt ccaaatgaat atgtcacctc taatttctgc cttgtttctt gtcttatttt 480
aattgtatct atcttctaag ygtcttatct ttacaaagta ccaatcctga accaacgagg 540
ttagatgctt aatttttctc gtgttttgct gggcatttgc tggctctaac agcaaagggg 600
cattaaccta accaaaaata aaatggtttc atatcattat aaaaattatt ctgtcagtgt 660
gaaatgccat aacaaaaaag cttgtatatg ttgatgtcat atatatatat ttatatttat 720
gtattcattt attcttattt tacatatata gttatttgtg gataagcagt tttggtgaag 780
aatagctagt atgtttttga gtagtgtcaa ggcctatact tttgagctat tttctaactc 840
caaacagatc tagaatcaat taacctttac caagggcctg ctatatttca gggtctggac 900
tgaacagacg attatgtcat tgaatcttca ttgaattcct gcataatgga tattctgatt 960
ctcattttgc aggtgagtta cctaaaattt agaaagaaaa a 1001
<210> 189
<211> 401
<212> DNA
<213> Homo sapiens
<400> 189
agtcctggat tctgagtgca aagtatagcc ttctctgttc ttgatgctac cagactgtat 60
tcaggaacac ttaagagaaa tgatggaagt cagagctgaa agctgtgtcc tcgccagatc 120
agtggaaggg cacgacaatc attcagctaa cgaaggaaac tccttggcta gccatgagtt 180
cattataacc aaaagtggga rtgggcagga tggggtgttg agggatacat gaattgttga 240
gcaactgctt tggaagggca ccaaacttca tgtttgttcc cttgcacact tgtcctttcc 300
ataattcata gaataattct atctaaaggt taatatagac cttgaagttc tcctagccca 360
gcccccactt cacgtttgaa tgttttctat cacatctcac c 401
<210> 190
<211> 401
<212> DNA
<213> Homo sapiens
<400> 190
ctatcacatc tcaccaaaca tcatgcctgg gtaagtccag gaataaataa ctcattgctt 60
cctgagccat cccagctcat tttgaggcaa ctctaactat ttgaaaaacc atcattcatt 120
tattcaataa atatttatta aatgccaact aagtgcccaa gcctggtttt agatgataga 180
aaaaaaaagt aaacaaacaa rcaccccgca cgcccccacc aaaaaaatcc ctactttcat 240
gaagtttgct tttcttacac taagccaagc taaaagttga tcttacctaa ccttcttcct 300
cactgagcta cttacaaccc tctaggtcct ctcattaggc atgggaaaag tgcttagttc 360
ttctcccatg taaatattta aagacactgg tagtaccccg t 401
<210> 191
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 191
cacatctcac caaacatcat gcctgggtaa gtccaggaat aaataactca ttgcttcctg 60
agccatccca gctcattttg aggcaactct aactatttga aaaaccatca ttcatttatt 120
caataaatat ttattaaatg ccaactaagt gcccaagcct ggttttagat gatagaaaaa 180
aaaagtaaac aaacaagcac cccgcacgcc cccaccaaaa aaatccctac tttcatgaag 240
tttgcttttc ttacactaag ccaagctaaa agttgatctt acctaacctt cttcctcact 300
gagctactta caaccctcta ggtcctctca ttaggcatgg gaaaagtgct tagttcttct 360
cccatgtaaa tatttaaaga cactggtagt accccgtttg gccttgtctt tttagttcct 420
acatttatcc atagttacat gttttcaagg ctcttcacta caccggctcc aaatttctgg 480
gcttgttctg cttcgttgtt sttccttttc aagtgcaatc ctcagaagtt aatcagctac 540
tccagatgag ttctgaccag cacagaatat agcagcggca tcattacctt gttctagttc 600
tcggatgtcc attaatacaa tctgagttta agttgccatt tttgatttca caaatcactg 660
ctgatgcaca tgaaactcag ctaatttttt caaccctgtt attatgtaag atacttactt 720
agattggaaa taggtccaca gcaaccagca acaaccacac tgctcatgag attctcctga 780
aaaacaagct cagcctccct caaagagagc tacgggacat tttcagccag cctgaagacc 840
acaagtgtgc ctggtgccag ccagaattgt cttccattga gagaatttgc agattctagt 900
aaatctcaag tctaaacctc agctaaatta tttagaaaca atgagcaagg gcagctctaa 960
cttggcccaa tatctgcaat aataaaagtt aatacatttt g 1001
<210> 192
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 192
aatcccttgc ccaaacttag acagatttta agggcaagta ggactcaaat atagatgagt 60
ggactccaaa gcccatgtac ctaaccactc taatcaccag acttctcatt ttcattgcta 120
acctgtcaag caatgttgct tgagagggaa ggagatgcat tcccccaaca cattattctt 180
tctaaatttt ttaagaaatg ttaataatca agcttagaaa caagcaaaaa aaaatgactc 240
cacagacata ttagcttggg agggatcaag ttggtttctc ccacaggttc tgagaagcag 300
ggaggctatc tgggatcctc tcataaaaaa tccttctgat tctgattctg atgtccacct 360
cacaagtcaa atggggaact gagcttgaca acaaatagcc gctttcttat ttctactcct 420
ttcccataat tttcaacagg agatgactat gttttatcta atgatctgac tctgtggagt 480
ggtctctagg ttgcaccccc vccccccccg agtgtgagct aatggaaatg ttttggagac 540
cactgatcca acttgctcta gagttagggc tggccccctc catccaaaac actcaagggc 600
cctgatatct tagtctgctc agtacaaagc cacacaatct gactctaccc tgcccaggca 660
atagtgcagt cctaaacact gtcctctgac ttcaggtagc tcatgtacca gggagagacc 720
tttcaaagac cggtgagaat acccaactga ccagtgatta agaaagggaa atttcagatt 780
cttgcacagt gaatacacag ttgagccaag tacagaattt tgattttctc ctctctgctt 840
atggataatt cattctttta tttcttcatc tatatgtgaa aatttgtttt ccttatattt 900
tctgtgttgc ttctattcct atcaggcttt cctgtacaca ctgtgtaact ccaacagaaa 960
caacctgaac tcctaaggat acaattgaaa ctattagttt g 1001
<210> 193
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 193
tcccttgccc aaacttagac agattttaag ggcaagtagg actcaaatat agatgagtgg 60
actccaaagc ccatgtacct aaccactcta atcaccagac ttctcatttt cattgctaac 120
ctgtcaagca atgttgcttg agagggaagg agatgcattc ccccaacaca ttattctttc 180
taaatttttt aagaaatgtt aataatcaag cttagaaaca agcaaaaaaa aatgactcca 240
cagacatatt agcttgggag ggatcaagtt ggtttctccc acaggttctg agaagcaggg 300
aggctatctg ggatcctctc ataaaaaatc cttctgattc tgattctgat gtccacctca 360
caagtcaaat ggggaactga gcttgacaac aaatagccgc tttcttattt ctactccttt 420
cccataattt tcaacaggag atgactatgt tttatctaat gatctgactc tgtggagtgg 480
tctctaggtt gcaccccccc bccccccgag tgtgagctaa tggaaatgtt ttggagacca 540
ctgatccaac ttgctctaga gttagggctg gccccctcca tccaaaacac tcaagggccc 600
tgatatctta gtctgctcag tacaaagcca cacaatctga ctctaccctg cccaggcaat 660
agtgcagtcc taaacactgt cctctgactt caggtagctc atgtaccagg gagagacctt 720
tcaaagaccg gtgagaatac ccaactgacc agtgattaag aaagggaaat ttcagattct 780
tgcacagtga atacacagtt gagccaagta cagaattttg attttctcct ctctgcttat 840
ggataattca ttcttttatt tcttcatcta tatgtgaaaa tttgttttcc ttatattttc 900
tgtgttgctt ctattcctat caggctttcc tgtacacact gtgtaactcc aacagaaaca 960
acctgaactc ctaaggatac aattgaaact attagtttgc t 1001
<210> 194
<211> 501
<212> DNA
<213> Homo sapiens
<400> 194
acagaaacaa cctgaactcc taaggataca attgaaacta ttagtttgct ataacttttc 60
tatttgattt accaagatac tctccctata gccaaaataa ttatatagca atctatgttg 120
tagcaaaagg aaataaacaa cggtgtttct taaacactta catagagagt ttagatgtat 180
tttttaacct tcttttctct ttttcatcta atttaaggtg agattccagg atctttctca 240
tgaaagatcc ycagagaatg tgcctgctaa acttgataga gtcacaaagc taggttacaa 300
aagagagcaa attaaattta gacccaaaag tgttgatacc acatatactg acgcatttct 360
tcaacagttt tcctttgttt atttattcag ggcactagag aaggtgctct aatcttttaa 420
taacagactc aatctgccat tgtcaaaatt atcaacaaaa ataataaaat gggttaaata 480
caaccacaaa aattcactgt g 501
<210> 195
<211> 401
<212> DNA
<213> Homo sapiens
<400> 195
agtcagtaaa atccagcaag cacaggtacc aacattataa agatgattca tacatggttc 60
caggcttccc aactagtgga agaggcagag ctagaaacag atgagttcaa tgtcatcttt 120
taaaatgatg gttattcata ggatgcttgg aaatgcagag gggcactaaa tatttatgct 180
caataaatag ttgtggcctc vctgtgtggg agtgtttgga gatctaaagg tagcatgaga 240
tgtacaaatg tggagtttag ttttaaagag accaccaaga attgcttcat ttatgagtgg 300
ccctggccct gccactgatt agctccatga acttgagcaa gtaatccttc tcagaatgtt 360
tcttttgttg ataaagttag gagttgcatg ataatgatgt c 401
<210> 196
<211> 501
<212> DNA
<213> Homo sapiens
<400> 196
ttttatgcca gatggcttta ttatttccct ggttccagat ccctttccct cttgcctttc 60
acgccctgtg ccctagggct gtatggtgtg tacccctata attctcccag cctgcagggc 120
aaaatgtaaa aacttcaagc ctctttttca gcagacagaa gggagggtca gggcaggatc 180
tcggtaggtt ttgtccaagc agtcggctca ctcttaagct ggcctgaggc agcagcacct 240
ccttacgctc vtgtgcagag atccagccct cccagtgccc cgctttgagt cccagggctt 300
ttctcagccc ttgcagccag ctgagccact tctaccactc ccaccagctt ataagagaaa 360
gagacttctt ctgtgctatg tctaatatta tcaggtccat tttgaaaatg agactaacat 420
agccacagct cctccctcca agggagactc tcatagcact attcaaattg catgatgaat 480
caagccctgc tgaactgcat t 501
<210> 197
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 197
aggtgttcct cagggcccag tccatgacac atgcttttcc atattaatgt atggaaaata 60
ctcctgtaga tttgagcagc taccattgct ttccctagcc ctttgctcag aagtaggcac 120
cagtccactg gctgttgggc aaaagcctgc tgagaaatcc aatgccttgg ccaaagatgc 180
tttgaagaaa tagtaagtga ggcagctctg acctcttctt atagaactcc ctgattcata 240
aaatcaaaca gcaaagactc ctagagacca ctgagtccaa gcctcttcat tttatagaag 300
agaaactgag gtccatagaa gcccattttt ttatagaatg agaaggaaag tgacttgccc 360
agggctcctg cttacagtag agttgggact ggcatttaca tctccttatc ctttacttag 420
tcctcttcgt aataaacagc gaaacactca ggggtccttc cttcctcttt ccaaaccctg 480
gaggagctga gggggagaca ygggggcttt actcctcgtg ttgtttcaga ctcagacttc 540
tcagcttcca cattgagaga ctatttgcaa ttgcttctcc ttgttgccca aattcctggc 600
tggcattcca gactgacacc agagacttcc ttcccaggga catccatcct gggcaggtca 660
gcagtttgca tcttccctgg ggcagaagtg gcagagtctc agaactcttg cttcttaaga 720
ctcagctcaa tctccacctg actcagcaga ggtttctgga atctcagatg ggtcctaacc 780
agaagcagct aggttgcttc tctgtttcta taatgagaaa acaaaaaaaa aagctgacta 840
tgaccattga gaaagaaaat gcacccatgt aaacacagca atctttaccc tataaataac 900
cctaattaaa atgaaaacac ccgagtgctc ccatcttttt tgattttttc tttctgctgg 960
acaccatggg aggtccttgc agcagagctc tggtgcttgc c 1001
<210> 198
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 198
ctatatctcc aatctcctct tctatccgtc tccctctctt aatcagtttt tgataatggt 60
ggcctgatgt tctttcctac cacagtcccc agcaatcttc acacacacac tgtttcttca 120
gcctgggatt ctcttcacca tctctaaaat gtaagcagct cctacacatc cttcacttac 180
agagacaccg tatcttccac acagacactc ctcggtcatc tccagactaa ctcgctgcta 240
gtgagcaact gcaacttatg ttcccatgta tccattcaat cttctcttaa taagcatatt 300
ccctcatttc tgggggactc tctgtccctc gctcttgaac cacatctcat tttggtgagg 360
ctccacatgg cacaggctta tgccaaatgg tggttggtat gaagatgggt tcattacaca 420
atcatacttt ttctgaggat gttggaatca acatctcact ttttcctact gtcttggagc 480
tgggatgtga gctgtaatgc hgctgtagct ggaaccctct caaaatggca ttaacacagt 540
agacgcagag ctttgaaatg gagaaagaga aaccagatat aaatggctat ggaattactg 600
ttgccaggga agcctgaagg cttcaactta taaaattcct cttcttcttc ttcttctttg 660
tttttatttt cgattaaagc agcttgactt gagttttctc tcatttttaa aagaaaaatt 720
ctccgttgca cactttgagc accctgagtc ttctcacatt ttggcattca cgacaagggt 780
aagcatttgt tcaatttcta tctctttcat actagattgg aaattccatg gaagttggaa 840
tcctatgagt cttatatatc actatttctc tcgtttctag tacaatgtgg agcacataat 900
gaaatatcaa taaaatattt ctgaatttaa tgaatgaatg aatgggagat tctgagatcc 960
caacccctat caggcctttt gttccatgat cctgatctga a 1001
<210> 199
<211> 601
<212> DNA
<213> Homo sapiens
<400> 199
tactttttct gaggatgttg gaatcaacat ctcacttttt cctactgtct tggagctggg 60
atgtgagctg taatgccgct gtagctggaa ccctctcaaa atggcattaa cacagtagac 120
gcagagcttt gaaatggaga aagagaaacc agatataaat ggctatggaa ttactgttgc 180
cagggaagcc tgaaggcttc aacttataaa attcctcttc ttcttcttct tctttgtttt 240
tattttcgat taaagcagct tgacttgagt tttctctcat ttttaaaaga aaaattctcc 300
rttgcacact ttgagcaccc tgagtcttct cacattttgg cattcacgac aagggtaagc 360
atttgttcaa tttctatctc tttcatacta gattggaaat tccatggaag ttggaatcct 420
atgagtctta tatatcacta tttctctcgt ttctagtaca atgtggagca cataatgaaa 480
tatcaataaa atatttctga atttaatgaa tgaatgaatg ggagattctg agatcccaac 540
ccctatcagg ccttttgttc catgatcctg atctgaaaaa agtgaatcta gttcccagtg 600
c 601
<210> 200
<211> 601
<212> DNA
<213> Homo sapiens
<400> 200
tcttggagct gggatgtgag ctgtaatgcc gctgtagctg gaaccctctc aaaatggcat 60
taacacagta gacgcagagc tttgaaatgg agaaagagaa accagatata aatggctatg 120
gaattactgt tgccagggaa gcctgaaggc ttcaacttat aaaattcctc ttcttcttct 180
tcttctttgt ttttattttc gattaaagca gcttgacttg agttttctct catttttaaa 240
agaaaaattc tccgttgcac actttgagca ccctgagtct tctcacattt tggcattcac 300
racaagggta agcatttgtt caatttctat ctctttcata ctagattgga aattccatgg 360
aagttggaat cctatgagtc ttatatatca ctatttctct cgtttctagt acaatgtgga 420
gcacataatg aaatatcaat aaaatatttc tgaatttaat gaatgaatga atgggagatt 480
ctgagatccc aacccctatc aggccttttg ttccatgatc ctgatctgaa aaaagtgaat 540
ctagttccca gtgcctagac ttgctgttct gttatggaaa gatctctatt agggagcatt 600
c 601
<210> 201
<211> 601
<212> DNA
<213> Homo sapiens
<400> 201
ggcaataaag gcaatagttt aatcttcaac ctgtggaatc cattggctat cccttagctg 60
gttataaaca aaggtaggaa aaaaatggga tactacttat tttccttgtg aagcccaaca 120
tatggttgga aacatttaga aatagaaaag gattggaatt tggtaaatta aatggcattt 180
ttacctcaag gcttcctgtg gggccttgat tataggcatg aggctataga ttttagcaac 240
taggtattgt gggattttga ccctatgtca cggggttggt tcctatatct gtgtggctgg 300
yttttaacta gtgcacttgt aaaggcctta gcctttagaa gtaaatcata tggcattttg 360
acttttataa gtcactagag ttaacggcaa ctttgtttgc aaatgataac tttttgtaac 420
attcagaaat ctaagcaaat gccaactaaa tggggtgagg ggcttagtaa acctgtgcaa 480
gccatgttat ttctggcaag gatctgatca aaggaaaaga gtcttcctgt tacacacatt 540
taggcactgt ggcagaacag ggaggagccg agggatatcc aggaaggggt gccgcagaag 600
a 601
<210> 202
<211> 601
<212> DNA
<213> Homo sapiens
<400> 202
gtggctggtt tttaactagt gcacttgtaa aggccttagc ctttagaagt aaatcatatg 60
gcattttgac ttttataagt cactagagtt aacggcaact ttgtttgcaa atgataactt 120
tttgtaacat tcagaaatct aagcaaatgc caactaaatg gggtgagggg cttagtaaac 180
ctgtgcaagc catgttattt ctggcaagga tctgatcaaa ggaaaagagt cttcctgtta 240
cacacattta ggcactgtgg cagaacaggg aggagccgag ggatatccag gaaggggtgc 300
mgcagaagag tcgtttgctg tttgaactgt gtttctcagt caagaaagga gttctctatt 360
ttaaacttca aaggtagcta ctttgcgttt gtgctacaga gcactgttat atgtgagatg 420
ctagctttac acttttaaac caagaatagt tagtccttga ttaagtaccc ataattttgt 480
tcattgttga tattattttg aacctctttt agagcctgga gaggaggtag ggaagaaata 540
actttgaatt caagtggttt atccacagat ccaagagtca ccacagagta aattgcttta 600
g 601
<210> 203
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 203
ctggagtgat tcccaagtgg cacctacaac ttcacctgtc ttgacttttt ctggtctttt 60
tctcctgatt ttgtattttc acttttgttt ctttacttga ccaagtttgg ctctgggtat 120
gatttatctg tggctgatgt ggtattcccc atagacggca acaatgattg agaatctggt 180
tttgtcatct gtccatttgg tgatctcttg gataacaaga atctagtctc tctaaggtga 240
gaaacagtag ataatgtggt taattaattt ttgtttgtct ttttgtctac ccatgagctc 300
aaataaatat tgtatgtctt ccaaaaagga taacaaatct ttgagatcca gcccggtgag 360
tgtgtttttg tgtttacttt gactcatgtc tgaagttata gaactgaagc catgggctct 420
ctgtatatct gtaagtgaag aaagccttta cctctcagta cataaatgtg aaatattctt 480
ctacctctgg agtgtattaa kaaattatgt cacaaagtat tttaaattat gttctatgtt 540
gtaattagct tagagagaat acgtgcttaa atgaatctat tattttccca gaattcagaa 600
tattttccta gaaaataaac taaaatttta atattttaaa tatattttaa agactatact 660
ttaagtattt tttaaaagta taaaaagccc tttttataaa aataattagc ccaaaagcat 720
ttttatgtaa aaatccaagt ttactgaatc aaggtgaaat ttttgttagg tcaaactggt 780
ttgtttggcc attttgtttc aaaatagcca tatatatagt tcccctgatc ttattagtgt 840
attaagcgta agtatatatt ttagttttat aagatttgag gtgtttcctg ataaagtgac 900
tagttattct gaacttccta aatttcttat attgacttac tgatcaaatt agctaatatg 960
acttctacat aatcatgatt gtgaaaattg taaaattatg t 1001
<210> 204
<211> 601
<212> DNA
<213> Homo sapiens
<400> 204
tataaaaagc cctttttata aaaataatta gcccaaaagc atttttatgt aaaaatccaa 60
gtttactgaa tcaaggtgaa atttttgtta ggtcaaactg gtttgtttgg ccattttgtt 120
tcaaaatagc catatatata gttcccctga tcttattagt gtattaagcg taagtatata 180
ttttagtttt ataagatttg aggtgtttcc tgataaagtg actagttatt ctgaacttcc 240
taaatttctt atattgactt actgatcaaa ttagctaata tgacttctac ataatcatga 300
ytgtgaaaat tgtaaaatta tgttttcaac caaattgaaa tacaatttta acaaagtttt 360
aacacattct ataatgtttc tgcttaaaaa taacttccaa gatccttagt taattttaag 420
atggactaac attacaccta gttaattaat ggctaattgt tggatgccta gataatttcc 480
aagtaagata gaatactcca aaattgatca ccatatacat agtatatata tatatatata 540
tagagagaga gagagagaga gagagagaga gagaaagaga gagagagaga aagagagaga 600
g 601
<210> 205
<211> 601
<212> DNA
<213> Homo sapiens
<400> 205
atatagttcc cctgatctta ttagtgtatt aagcgtaagt atatatttta gttttataag 60
atttgaggtg tttcctgata aagtgactag ttattctgaa cttcctaaat ttcttatatt 120
gacttactga tcaaattagc taatatgact tctacataat catgattgtg aaaattgtaa 180
aattatgttt tcaaccaaat tgaaatacaa ttttaacaaa gttttaacac attctataat 240
gtttctgctt aaaaataact tccaagatcc ttagttaatt ttaagatgga ctaacattac 300
rcctagttaa ttaatggcta attgttggat gcctagataa tttccaagta agatagaata 360
ctccaaaatt gatcaccata tacatagtat atatatatat atatatagag agagagagag 420
agagagagag agagagagaa agagagagag agagaaagag agagagagag agagagagat 480
tgagagagag taagaaacta tatgtacata gttttttact tttatatgtc atggagtggc 540
tacacctttc agtcatgtta atgaatatgc tcttttttgc cactttagaa aggatttgtg 600
t 601
<210> 206
<211> 601
<212> DNA
<213> Homo sapiens
<400> 206
tgatgggcct gatttgaccc agtgggccac agtttgtcaa catgtgatct aaagcatcct 60
aaaatttttc tatttgctac cctgggacct tgattatttc agggccaacc taatttccaa 120
gtccaaggta tatgaagcat aagctttctt tggaggactt tttaatgggc ctttggattg 180
gtgaaaccat tttcttttac ctctgtctaa ttggatattt tatcttctat gtggtagagg 240
ctaacaggca ccagtcatct tctacccaag ttggaattaa gagagaaaca cctaagttag 300
rcaagtaggg attaaaatgt cagttttatt atagataaaa tccatttcag agaatccagc 360
tgaggtttac agctagtgac tatgcaagta atttattctg aattaaacag acctgctcac 420
ccaatcacaa gcacatctgg acacaggcct ctccacatgg acctatgtcg gtaaaagcta 480
gagtgcaaag caacaaggat gtgttcgctc tgcagcaata tctcaggaga tgaggaagga 540
aggtgctgaa ttatgcatcc ccaagtttat ctcccaaatt ctcaattgga aaatattatt 600
c 601
<210> 207
<211> 714
<212> DNA
<213> Homo sapiens
<400> 207
ataacttctt actcttttac tcccttgatt aaaatgttaa atgacccctc tttcctcaaa 60
agaaaaaaaa aatcagttct gatatcttat cctggtatta aacatgcttc actctctggc 120
actagactac tactacctag tatgactctc ctctctggcc aggtaagtct gtttataacc 180
tctgtaagat gacacttaaa ttttgcctcc ttgyctttgc caaggccatt gcttccacct 240
ggaatgcact ctttaattgt tttacttgat tcatatctat ctttcagcgc ccagctctag 300
cctctgtgaa gccttcctgg atcactctag ttctcaaagc cctctctgcc cttgaactac 360
taaagtcctt actgtctgta tcttaggcat ttgcagttgg tgttgttaat tttgcataat 420
tatatcctat ctccaaattg agatgttcag ttctttgagg atcagaaaca tttgttaggc 480
atctttatac cctcaaagca actagcacag tgatttcaca taatgtaagg gttcatatgt 540
ttgctcatgt gttatatacc ctttaaaata atttattaaa taattattta attacttatg 600
ttatgttata aatatataac aacaacgact tctcactaat ccagactagc tccattagta 660
aaagttaatg aggatgtgct ctattcagaa tacgtttcat gtgtttttgt gctg 714
<210> 208
<211> 701
<212> DNA
<213> Homo sapiens
<400> 208
cattgcttcc acctggaatg cactctttaa ttgttttact tgattcatat ctatctttca 60
gcgcccagct ctagcctctg tgaagccttc ctggatcact ctagttctca aagccctctc 120
tgcccttgaa ctactaaagt ccttactgtc tgtatcttag gcatttgcag ttggtgttgt 180
taattttgca taattatatc ctatctccaa attgagatgt tcagttcttt gaggatcaga 240
aacatttgtt aggcatcttt ataccctcaa agcaactagc acagtgattt cacataatgt 300
aagggttcat atgtttgctc atgtgttata taccctttaa aataatttat taaataatta 360
tttaattact tatgttatgt tataaatata taacaacaac gacttctcac taatccagac 420
tagctccatt agtaaaagtt aatgaggatg tgctctattc agaatacgtt tcatgtgttt 480
ttgtgctgct gttgcctaga wccatgaaac agatttgtag ttggttgttt ccagtcctga 540
ggaaatgtgg gcttgctgag cttctgaact acatccttct tgtgagcagc ttagatttca 600
aggttacgtg cttccagaaa tagaaaggga gtatttagat tctttccttc cctgtcaaga 660
aactctgttg aatcatcttt tggcaataat gccaaagtaa t 701
<210> 209
<211> 701
<212> DNA
<213> Homo sapiens
<400> 209
cttctgaact acatccttct tgtgagcagc ttagatttca aggttacgtg cttccagaaa 60
tagaaaggga gtatttagat tctttccttc cctgtcaaga aactctgttg aatcatcttt 120
tggcaataat gccaaagtaa tttgtaagcg ttagaacatt tgtgcagaca gcataagttc 180
cttcaaataa tgcagttgca yaaagcagta atgttaatta gtcaaagcaa cttttttaaa 240
atcagtagtt ctatgcacat gtgacaccac cttggtaaaa agagctttag aaatttgaag 300
aaaattttga gttgtcccaa tatcgagagg ggatgccact gtcacttatt gtgaaatagc 360
tagggatgct agatgtcctg caacgtgtaa ggcattctca tgcagtgaaa aattgcccca 420
cattctaact ggtcttcaaa tgtccctcca tacatttatg tggatgaaaa ctatttaaac 480
ttatctgagc ctaacactta atgccattta catataaaca cctaggatct agtttttgta 540
cagtttaaat acatgatttt gtacagtttg aatttttgca actgttatgt aaatcaaaga 600
aagattacgt tttgtctcat atggaaattt aacaagcttc atttatcatt gtgaaaaatc 660
atgttaccag tggaagtacc acttttggta tttgaatacc c 701
<210> 210
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 210
cctcaaagtg gcttaaaata acaacgattt aattatcatt tacaagtctg tggatcaatt 60
aagaggttct gctgatccaa ccccagctct aatctcagct gtgcttcctt atgagtttat 120
ggtcagctgg gagttggctg gtctgggaca gcctcagtca ggatcctcca gcagactagc 180
ctgggctttc tgggtaatgg tggggttcaa agagagtaag cccaggcctg caaagccttc 240
tgagactcag aattggcaca gtcaccactc tgcagcattt cattgaccaa ggcaagtcac 300
aaggccagcc cagattcaca gggtaggaaa agagacttca cccctcggcc atggaaggag 360
ctgcaaagtc acattttaaa gagggtaaga gtgtagacac aggaaggggt ggccattgtt 420
gtaatcagca gcaccaagtt aaggcgtaaa gaagggatag gagtcaacca aacagttagc 480
tgaagagaac tgtggtcagc rtgtcaaggc cctgaggcaa gaaatagcat gcagtcgtcc 540
agaaggctaa gaaagccaga gcggcagcat gctgagagtg aggggtgagt tgtacaaaat 600
gaggctggta agaaggaaag ggtcagatgt tgcagagcca tgtagtgtgg gccttgttgc 660
gattttcatc ctttatctga agaaatgttt taagcaggag agggagatga ttagttattt 720
aaattttctc cagtgatacc aatgtgcaac caaggttgaa actctctgtg taaaagaaag 780
gcacaactta ggaagttgtt attacttgtt atccaggtga aagacgacag tagcttgaat 840
gagtgtagtt acttagtgaa tgaatgaata aataaaatta aactccaagg gagagattta 900
ggatccacag gaagactgcc ttgtttcaaa tcacagctcc agcacccact agctgtactt 960
gctggggaaa cctcagtaca ttctttcatc cctttgtgcc a 1001
<210> 211
<211> 701
<212> DNA
<213> Homo sapiens
<400> 211
tgtaaaagaa aggcacaact taggaagttg ttattacttg ttatccaggt gaaagacgac 60
agtagcttga atgagtgtag ttacttagtg aatgaatgaa taaataaaat taaactccaa 120
gggagagatt taggatccac aggaagactg ccttgtttca aatcacagct ccagcaccca 180
ctagctgtac ttgctgggga aacctcagta cattctttca tccctttgtg ccacagagcc 240
ttctttccca aaacggagat agcaataata cctaccttag cagtgcatta taaaaactaa 300
tgcattaatg ctcatagagc agttatcatc atgccaggca aatgataggc actccataaa 360
cgttaactac tgtgattgtt gttaaaagga tgatgtctga ggcagtacag tatctcatgc 420
agaaaagctc tcatcccaaa atgaatctct attctaatcc caactatacc ctgtagctct 480
gactgtgctc atgtggttgc rattaagcca aagcccaagg tgggaccaga tactgtccat 540
ttcatctcgg cttgtcatcc atcctcctca ggtctgcctg gtgctctgac atctggcttc 600
cactcatctg ggggaggaca gggagaagcc agacagccat gaatcctgct gtctgctcac 660
aaattcgcag tctagggagg gctaggggga gttgctgtca g 701
<210> 212
<211> 401
<212> DNA
<213> Homo sapiens
<400> 212
gtcacctagg tgctattggt agatacaaag tgttttatga gcgatgctgg taagagctct 60
tttccaagtt atctccccag gcacctctgc ctgaaattgg tggtggttac aagcagagtt 120
ttgaagaaag acctgggtct ggaccctctc tcccctgctt acagttgtgg gattccaaaa 180
aagctactgt ctctgtttct yatctggcgc tggggcaatg actcctgcct tacacagcca 240
ttgtgtgaat actaatccat gatgtcatac cgcacatgcc caagagcagg caggaggccc 300
tctccctcac ttcttccagg ctctgatgga atggcagctt agtaacagcc ttgctgtagt 360
caccccgtat tcagcagagg ctctcctcca gcccaacaca t 401
<210> 213
<211> 701
<212> DNA
<213> Homo sapiens
<400> 213
aaaggctctc cccagcctcc tgccctgctt caccattccc cagtgtcttt atctccacct 60
gaagtttcac atgtacttgt ctgtctctcc gaagaattta agtgccacga gggcacggtg 120
gtttattcac ctctttaata gtagctggca tgcagtaggc actctgtagg catttggaat 180
taatgaataa gtaaatacct ggattaatta actagtattt caagggagag tgggatcctt 240
gggaaagaag gatagattac accacagttt gctatagaag gatgcctaag attggtcttt 300
gtcagttaat tactcactga tataacattg gctagtcagt tgctcttgag cctcagtttt 360
ccatatctaa aaaagagaca atgtcactta ccatacttac ctcaaacagc tagatggagg 420
ataaatctca aacatgggaa taagtctgct ttgaacactg taactcacca tgtaaaaatg 480
agaatttgga tttttttaag waacttagca gttaatttcc tgggtaatat cctaatagag 540
aaatgtccca cgtggtatgg gacaaaggag aatgcctcat ttggatccac atctgatttt 600
aaaccttgct gcatcaacct gacccaccca acacaacttc actcccttgg tcccagattg 660
gcaggcacac aagccctgag gacagtatgg cttcaggtct c 701
<210> 214
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 214
gccctgtcaa gcaagacgcg cagcttggca cagccagccc tgtagccagc ccaggcctcg 60
taatgggata cagagctcgt cgctaggtgc agcagagttt gcatcaggcg ttgtcactgt 120
ctggtggttg cctggtgacc ctaatggaaa atgagtggag gcagccccta ccacagaaac 180
cactccctca gctggcaggc ttgtcggaaa gcccagtgcc atgggagggg gaggggctgc 240
cacagaggag ctgtcaccca ggcgccctgt gtaggtggtg gcagggacgg ggagagaagg 300
gcgcagagcc acaggagggc tcagcagtgg tgtctgctct cccttctgca tgaattgttg 360
ctcataaaag atgggtgagc ccagcacagt aactaatgct tatccccagg cccaaattta 420
ggtaaaagca cacaaaaagt ctcatcagtg gtcaatgctc cacagctcca aacacaggaa 480
ggtgcattct caagctgtta ygagaagctc actcaagctg atggtattga cagccacagc 540
ccccatgcag ggaaggctgg acccgacacc tgcccacgag aagcagcata cctgggactg 600
gagggacttc ctggcctata agaagaacac taagagggga ggaggactcg ggctgattgg 660
gaaaacagat ggtgagctcc atccgtggga aaataaatga cagcgtgcat ttaagaggtt 720
gagccccaga gccaagcctg ctgaaatgcc agcttatcaa aagcacagga gcactgtgtg 780
ctagacgctc tatcatactc tcttccatcc tggtttctct taatcccaag ataatgtctg 840
taggcattgg aaagtcttgc ttgagagacg aagaaatgta ggctcagaga ggttgaacag 900
tttgtctgag gtcacacagc tactcaatca caggatttaa cacaggcttt tctgctttca 960
agtctaacat tccttctcct aacatcgtgg gagaaagtga t 1001
<210> 215
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 215
gttaattgtg gctcaccaag gcttggagag agctggatga gaggggagca gagtccagcg 60
tgggtggggc tggactggca gtggcagagg agaggcagct gctgttcaca tcagggtctg 120
gatggccttg tcgccgcagg aggctgcgct gctccaccct cccaagcgtt tcccagctcc 180
gtcacagggt ctccgttccc accacagtgt gtcccagcag ttccatttgt atttgtaccc 240
agagagctcc actgaggcct gtggtcacag agtgactccc ttccatgttc tgccacaggt 300
tgcaagccat agggtgaagg tcacacagtt ttgtttggcc ataacagctg cctccatggc 360
aacagcgtgt gatatcactg gaaaagccat ttgtgggact ccaagctgga aggaaaaggc 420
agagttggag agagctgtag cgggagacag agaaagggca gggtctctcc ggatgctcca 480
aggtgctgga cgcacaggtc sctttctgta gtccttgtca tgtaagatct tttcatttag 540
gctaagcaaa tccagatgtt cttcaaataa ttcaggcata tttggcccaa gcataaactt 600
gtcttcattt ttcatccaat ctgacaaacg tttgcaatcg cctcactctg tgagttccag 660
gacaccttcg ggctggaagg ggttaatgag aacaagccct ccctggtggc ttcccttccc 720
cctggtgctg cccctcggcc cctcccaggc cagcaggatt tgctgtccaa aggccctcaa 780
aagacatcca agcagtcttt tcttagaaac aggaaactgt cttcggccaa gtacaaatga 840
agtgaagcac ccagaaacct gaggaccgct ccaaactgag gcctggaggc agacagggag 900
ggcccaactc ctggcagggc ctccaggact caggctctca tgaatgagac tgagctcagc 960
tgcagcctca gccattcttc gttgcactca acccattatg t 1001
<210> 216
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 216
agggatagct gactatgagc ggccccactg ggctctcaag gtaccatgaa ggatccagtt 60
cccctctggc tgagctgttt gatcctaaga catccctgtt ggttggcagg gaccattttg 120
tcactgtttt ctgtcatgcc ttgttttctc attctttctg tcacatattt ctaagtgaga 180
gggaaagtta aagccacgga atcgcttatc atctcctccc tctgcctttg ggtttactca 240
gagaaagtca tatcttgaca ttcccaggag tattactatg cctttaccca ttttcagtag 300
taataataac caagttccct ttcccatttc cacctacatc cagccactga aatggaatta 360
acaagagtac cagaactaca tatattgcca gcagttattc ctgggaagat ggaagaagaa 420
aagtcctaaa catccaactc ctgggtacct gcttgcttga aactctaaac atcagtctta 480
ttcgctagtt atggaagtaa hgatatgtta ggtgatactc tgagaaagct gtgagctaaa 540
agttgcctta cattgcagaa ctctcagttt ccagagaagc agcagacaac acagattata 600
gactctgcag tcaaccaacc agtcctgtta agaacaaact cagccactta gttacgtgaa 660
tttggacacg ttgtttaatc actccccata cttgcctcag ttttctcata agcaaaatag 720
gcatattgag agtacattgc tcttaacatt gttgtgacaa tgaaatgata taatttatgc 780
agagtgaaca acactatgcc tgacacatag caagggctct acaaatgtta gatgttgttg 840
ttgttactat tattcggtat actggataat actgccagat tcaacatgtt tgtgcatttc 900
tctcaaattc gcggttgaaa gtatacaaaa aacaaaatca aaaaaatgtc tatttctctt 960
agccctgtgg tgtctctggc acaactcgtt ctaagaaaag t 1001
<210> 217
<211> 501
<212> DNA
<213> Homo sapiens
<400> 217
tttctcataa gcaaaatagg catattgaga gtacattgct cttaacattg ttgtgacaat 60
gaaatgatat aatttatgca gagtgaacaa cactatgcct gacacatagc aagggctcta 120
caaatgttag atgttgttgt tgttactatt attcggtata ctggataata ctgccagatt 180
caacatgttt gtgcatttct ctcaaattcg cggttgaaag tatacaaaaa acaaaatcaa 240
aaaaatgtct mtttctctta gccctgtggt gtctctggca caactcgttc taagaaaagt 300
tagagctagg tatggtgaat tgtcccaaca acaaagcttt catcaaacaa agcagcaggg 360
agattctcaa gtctcctttt attattatta ttgtacttta agttttaggg tacatgtgca 420
caacgtgcag gttggttaca tatgtataca tgtgccatgt tggtgtgctg cacccattaa 480
ctcatcattt acattaggta t 501
<210> 218
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 218
ccccggtgtg tgatgttccc cactctgtac ccaagcattc tcattgttca attctcatgt 60
gagtgagaac atgcggtgtt ttttaatggg ctttccacct ttgtctgtag cgggggcaat 120
gttatctatt cagttcagtt cagacacaca agtgggctcc caacttccct caggctccaa 180
tattagccat tttcctctta gtgtgaattc caccagaata ttatcattcc cccactgtag 240
tagtgtggaa acacttatac tcagtgtcaa atggaaattt gggagcagat gtgcaagcac 300
gaagttcttc cagggaattc taaaagacaa acagggaagg cacttgtata tgggaacctc 360
aagtgctcgg ttgtcaagta gagcctcaat tcaaatcatc tcatttgtta ttttcataaa 420
ccctcaatgt tttctggaaa ctatattttc caggatgttt ctcacacttg gatgtagcaa 480
ggaaatcatt ttttatatca ygtgagtctc aaatttagtc catgaaattg agcaaattca 540
ttaatggaaa gacccttgga ctgagaattt attctactgt cactagagga ctttaatggg 600
ctaagaaaga gaagaaatta cagataatat ccaaagccca gcacgatacc ataaaggccc 660
ctcccagatg agtccaagac ctccagaaag aactaccaat gcctgaagtt ccagtaaaaa 720
cctccctcaa gaatgatcac attcataaca gaaagttatt actaccatca tccctggaga 780
atctcaaagc aaaatctatt atcctaatac agcatcactt gaattataaa gtctgatgaa 840
accagacttg gaggctaaat gatgtacaca gagttgcggc atctatcagg gagctcatcc 900
tagaacttga ttgtcataac aggttcattg caattttcgc tgcctgtgga actttgtgcc 960
ataacctgac tctccaacca aatgtgaatg tagcttaatt a 1001
<210> 219
<211> 401
<212> DNA
<213> Homo sapiens
<400> 219
tatattttcc aggatgtttc tcacacttgg atgtagcaag gaaatcattt tttatatcat 60
gtgagtctca aatttagtcc atgaaattga gcaaattcat taatggaaag acccttggac 120
tgagaattta ttctactgtc actagaggac tttaatgggc taagaaagag aagaaattac 180
agataatatc caaagcccag yacgatacca taaaggcccc tcccagatga gtccaagacc 240
tccagaaaga actaccaatg cctgaagttc cagtaaaaac ctccctcaag aatgatcaca 300
ttcataacag aaagttatta ctaccatcat ccctggagaa tctcaaagca aaatctatta 360
tcctaataca gcatcacttg aattataaag tctgatgaaa c 401
<210> 220
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 220
gcagagcccc gaggcagata tggcatttac ggagacttta tcatggaagc acaacagctt 60
gtcctcagtg gaatacagca ggagatccct cgaagatctg tcaggcttgg ccatttagag 120
gcttggaccc ctgactcctg ccaagagcag taaggaagcg tgggggccaa cacctgtgca 180
catactctca tgccctcact ctccactcat tgtgcagagc agaaaccaga ctcagaagtg 240
ctccaggcca ggctttcttc accaaccttc accagcctct gctggatttg gccgtttgca 300
gtgaaaaatg agcctgaaag ccctggaggc ttcctggtga tttaccgaga attttacttc 360
cacatgggct ttccagctgc agccaacccc aagaggcaga ggtaggaaga ggaagaaaat 420
cataaatgga tagtaagatg agaaacagat gtttggaggc ttcactggaa gggaattctc 480
cacctctact ccctttcttc rtgagatgag aaggctcggg ccctaatgag cagtttctca 540
ctatacctgc aattcatctc cttcccccac caccagctct ctcaagtgtc acttttcaag 600
ggtcttcctg gtcctgccac atgggcatca actttgttgg gtgatttgtt tctggtttta 660
gccaaaataa atgaatgcta ggtgctctga ccatagacac atgttagaca atctcctgcc 720
ctcagggtgc tcaccagccg gaatgaataa gcaggtgcaa gcgtctgccc cctgacagag 780
gcaaggactg gaccctgaaa acccacagga ggggcagcaa acccagcctt ggctcaagga 840
ggcactggag ggtcaaagga aagctcagct gagttgtaaa gatgttaatc aattgaaaat 900
ggatagaagt cactttggag gtattaacct agcaggcttc aagagagttg tatatttatt 960
cagtgtaaca caagggttga gagcaacatc cccaaagcta g 1001
<210> 221
<211> 601
<212> DNA
<213> Homo sapiens
<400> 221
ccacatggac tggtgcacaa cccatctcta gcccccagct ctctctcacc cccgctgagt 60
caggttctca ctgctgttca catcatattt ttgacgccca aattttctca tagcattcct 120
caatttaaga ttcttttgtg gtcccccatt ggctattgaa aagtaacgga attccttaat 180
gtgacagatc cctttgtgaa tcgattctta ttttcctatc cagtcccagc tctggacacc 240
ctcagtgcct ccacccagtg gatgtattct tccgtgaaac cactgtgctc ctgctgtgga 300
yacgttgtct cccataacag gaacagtgtc tctgtcctgt ccaccaaaca ctccgacttt 360
ttccctaaga attttcacat tgcttcgtct gtgacaacgt ctgtgattcc tttgggtccc 420
cctttctcaa gttccttgtg ctctgcacct gtctacatga atgatgggga gggttggaag 480
gagcagaaca tattaatagc actctccttt tctacccaag ctctgcaaaa attaagaaat 540
aaaaataaaa acaaaaaaca gcatatgaga caggatacca aaatatgacc cttattactg 600
a 601
<210> 222
<211> 401
<212> DNA
<213> Homo sapiens
<400> 222
gggagcttcc taatgatatt tccagattag gctaacttac actcccaaat gcaggctcag 60
atgaacaggt cacctttccc cactcggggg cctataccag tatgagaatt atggcatggc 120
ctaacaaaaa caaatataaa tccctcacgg gcaggactaa tttcttcttt caaaacccac 180
ccattaaaca tagtattcct rggaggggag caagcaagga gcagagaaaa gctgggagtg 240
tcacactaat ggagctcctt ccacattaaa ggaaacacca ggagtaaaga agaaaagtgc 300
caacatgtta tatagtattt tcatttttgt gtctcttgat gaaactaaaa gctatttgta 360
ggcgagaata atgctttttc atctaatatt ttcatcctat a 401
<210> 223
<211> 701
<212> DNA
<213> Homo sapiens
<400> 223
aaccccgtct ctactaaaaa tacaaaaaaa aaaattaact ggatgtggtg gtgggcgcct 60
gtaatcccag ctactccaga ggctgaagca ggagaatcac ttgaacccag gaggtggagg 120
ttgcagtgag ccgagatcat gccactgcac tccagcctgg gcaacagagg gagagtctgt 180
ctcaaaaaaa aaaaaaagaa gaaagaaaga agaaagaaag aaagaaagaa agaaagaaag 240
aaagaaagaa agaaagaaag aaagaaagaa agagaaagaa agaagaaaga aagaaagaaa 300
gaaagaaaga aagaaagaaa gaaagaaaga aaagaaaaaa gaaaagaaaa gaaaagaaaa 360
aaaaagtatt atgtgcatgg actttgaccc agtagagtgg aaacagagtt gcttgccagg 420
cactctgttc tggaccctgt ctgcccaccc tcaagagaag cccccagtga tgggtgtctt 480
tccccacagc cacagctaca yaggcaggag taagcactga gccccgtcct ctggattttt 540
aaattgtaac agagaaagag agagatttgg cctcttgtta tgtagctgga ccgatgatgc 600
ataaattctg gaattgctgc aaggtcatgc ttcctatcat gtggaacaag aaaaacagtg 660
gaaacttgcc taccaagaga gagaagaatg ccacagatgc a 701
<210> 224
<211> 1202
<212> DNA
<213> Homo sapiens
<400> 224
tttagaaaca gctgctcaca tataccatta gtagaaatat aaagataaat cattttggag 60
agaaatctgg gaatatacat taaaagtgtg gctcatgcct gtaatcccag tactttggga 120
ggccgaggtg agtggatcat aaagtcagga gttcaagacc agcttggcca agatggtgaa 180
accccgtctc tactaaaaat acaaaaaaaa aaattaactg gatgtggtgg tgggcgcctg 240
taatcccagc tactccagag gctgaagcag gagaatcact tgaacccagg aggtggaggt 300
tgcagtgagc cgagatcatg ccactgcact ccagcctggg caacagaggg agagtctgtc 360
tcaaaaaaaa aaaaaagaag aaagaaagaa gaaagaaaga aagaaagaaa gaaagaaaga 420
aagaaagaaa gaaagaaaga aagaaagaaa gagaaagaaa gaagaaagaa agaaagaaag 480
aaagaaagaa agaaagaaag aaagaaagaa aagaaaaaag aaaagaaaag aaaagaaaaa 540
aaaagtatta tgtgcatgga ctttgaccca gtagagtgga aacagagttg cttgccaggc 600
actctgttct ggaccctgtc tgcccaccct caagagaagc ccccagtgat gggtgtcttt 660
ccccacagcc acagctacat aggcaggagt aagcactgag ccccgtcctc tggattttta 720
aattgtaaca gagaaagaga gagatttggc ctcttgttat gtagctggac hgatgatgca 780
taaattctgg aattgctgca aggtcatgct tcctatcatg tggaacaaga aaaacagtgg 840
aaacttgcct accaagagag agaagaatgc cacagatgca cagacaggag aaacaagaga 900
tggagaggaa gttctgacag tttttcagtt cctggctctg gaacctgcac agttccagct 960
gccttcctga caatcacaga ggcccatcac tcacctctga atctagaaat tttttttttt 1020
tcccaaggag agctcaagat gcttcctatt acttgcaact aaatgagtct caacagtaat 1080
tccattccta agagttttag ccttaagaaa cagtttcaga cacacagttg catatgtaaa 1140
gataaatacc atagtattgc atgtaatttt gataaaatga tcgatttgga tattaatgtg 1200
ac 1202
<210> 225
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 225
gatgcacaga caggagaaac aagagatgga gaggaagttc tgacagtttt tcagttcctg 60
gctctggaac ctgcacagtt ccagctgcct tcctgacaat cacagaggcc catcactcac 120
ctctgaatct agaaattttt tttttttccc aaggagagct caagatgctt cctattactt 180
gcaactaaat gagtctcaac agtaattcca ttcctaagag ttttagcctt aagaaacagt 240
ttcagacaca cagttgcata tgtaaagata aataccatag tattgcatgt aattttgata 300
aaatgatcga tttggatatt aatgtgactc ttgtcaaaca aaccatctta atagtagaaa 360
catattaata tcattaatta atgcttaagc cttacttcat attcattttg tctcaggggt 420
tggattttgt gcttcacata catctatttt aatcctcaca gcagccctag aagatgggta 480
ctattacctt aagataaaca ygtaaagtgt ttagcatatt gttttgcata tagcaggact 540
tgcaaaatag ctaactacta ttattccaat ttctacagat gagaaaatta gaactttttt 600
agctttatag ccagaaattc caaaggtgct cagataaatg tagtgggaaa atgtaatgat 660
gtgtgggaaa gtgagacagg cagagcacct aaaaggtacc ccctcctacc tattgatctt 720
gacagcaagt atcagatggc tgtacttaga ttgagtgtta gaggctaata cagtaattca 780
agatgtgtaa aagtcaacaa aaagaattag ttatcaaaca agttacattc aaggtatgga 840
atgaactata cacaaacggt caacagacat gcaaacacac atgcactttt ctaccaataa 900
cagcagatat agccacacgt tgggcagtta ataccaagtt ttgcttgttg gctaagggaa 960
ctttcagtat cctaattctg attccatttt ttttttcact g 1001
<210> 226
<211> 3766
<212> DNA
<213> Homo sapiens
<400> 226
ctaactgggc tatgaatgac ttgagcttgt ggtcttggcc tcattaacac tggacaacaa 60
ccaactgagc taatcagcca ctgctgacat tacagagaaa ctttattgag gtataattaa 120
agtacattaa accatacatg tataaaatgt acaatttgat cagcttttga atacgtatat 180
actcatgaaa ccatcaccac aatcaaaata acaaacattt aatcaactcc agaagtttct 240
ttgtgtccct ttataatcca ttattcctgc acctccatcc tcagcaactg ctgatctgtt 300
ttctctcagg acagaataat ttgctttttt ctagaatttt atataactgc aataatacag 360
tttgtactat ttggcttgtt atattttaat atctttagaa actagatatg ccccctctct 420
catttttgat attggtagtt tgtcttttct ctttttgtgc taataagtct agctagaaga 480
ttattgatct ttatgagttt tgcaaggaac catctcctga tttcattgat tttttttcaa 540
ttgtttttct gttttccagt gcatttattt tggctctgat catttcatgt cttttccttt 600
ctttgggttt tatttgcttt tattcttcta gtttcttaag gcagaagctg agttcattga 660
tttgaagatg tttttctttt ttaatatgaa acctttttgt tctataaatg ttcccctaag 720
tgctgcctga gctacatctc acatattttt tgtattttgt tttcattttc atcgagttcc 780
aaatactttc cagtttctct tttgattttg tcaatgatcc atgagttatt ttaaatatta 840
tcttgagact acttgggata tcccagatat ctttctgata cactcatttc tgatttaatt 900
caattgtggt tactgtagga cagattttct attacttgac tccttttaaa tttactggga 960
tttgttttct cattcaacat atggtctctc ttgggaaatg tttcattaat acttaaataa 1020
aaagtatatt cggtggttgt tgttgttggg tgcaatgttc cgtaattgtc agttaggtca 1080
atttagttaa tagtgttatt caaatcttct aaatacttat ggactttctg tctatatgtt 1140
ctatcaatta ctgaaatctc tgactataac tgtgaatatg tttgtttttc cttaagtttt 1200
gctccatgta ttttgatgct cagttattat atgtgtaaat atttaggatt gttatatcat 1260
cttgatgagg cgactacttt atcattatta aatggccctc tttatccctg gtaatctttg 1320
ctttaaaacc tactttttaa tatgaatata gcctcattag ctttattttg atgagtatta 1380
acattgtata taacttttca tctttttatt ttaatatgtt tgtatattta aagtgcattc 1440
cttataggta acatatagtt gagtctttct ttttatccaa tatgacacct ctgacttgac 1500
tttgaagtgt ttaaactttt tgtatttaat gtgaatatgt atatgatcgg ttttaaattt 1560
accagctggc tagttttttc tgtttattcc atctattatt ctttgttccc tttttcctct 1620
atgctttctt ttgggttaat tatactttta aaaatatttc gtatatcctt tgttgtatta 1680
ttttagtggt tgatatagtg tcattgatta cgtctttaac ttatcacagt tatctttcaa 1740
gtaacattat accactttgt acatgygtat tagaaaacct tgcaacaatg tacttccatt 1800
ctctgtctcc tgaattttat actactgttg tcgtcataca tattattttt atttctacat 1860
atgtaataag acctatatta cattgtttct gtgtttgctt taaaaaacca agttttcaat 1920
gaaatgttta aaatgagaaa atatatttgt ctacataatt ttttttcaag gctcttaatt 1980
ctatccagta tatcagactt ctatctggta tcatttttct tctgcttgaa agatgtcttt 2040
tatcagggat gccctctctt accactccta ttcaacatag tgttggaagt tctggccagg 2100
gcaatcaggc aagagaaaga aataatgggt attcaattaa gaaaagagga agtcagattg 2160
gccctgtttg cagatggcat gattgtatat ttagaaaacc ccatcatctc agcccaaaat 2220
ctccataagc taatcagtaa cttcagcaaa gtctcaggat acaaaatcaa tgtgcaaaaa 2280
tcacaagcat tcctatacac caataacaga aaaacagaga tccaaatcat gagtgaactc 2340
ccatttacaa ttgctacaaa gagattaaaa tacctaggaa tccaacttac aagggatgtg 2400
aaggacatct tcaaggagaa ctacaaacca ctgcgcaacg aaataaaaaa ggacataaac 2460
aaatggaaga acaatccatg ctcatggata ggaagaatca atatcgtgaa aatggccata 2520
ctgcccaagg taaatttata gattcaatgc caccccacca agctaccaat gactttcttc 2580
acagaattgg aaaaaactac tttaaatttc atatggaaca aagaaaaacc tgcattgcca 2640
agtcaatcct aagcaaaaaa aaaaaaaaag ctggaggcat cacgctacct gacttcaaac 2700
tatactacaa ggctacagta accagaacag catggtactg gtacaaaaac agagatatag 2760
accaatggaa cagaacatag gtctcaggta taacaccaca catctacaac catctgatct 2820
ttgacaaacc tgacaaaaac aagaaatggg gaaaggattc cctttttaat aaatagttct 2880
gggaaaactg gctagccata tgtagaaaga tgaaactgga tcccttcctt acaccttata 2940
caaaaattaa ttcaagatgg attaaaggct taaatgttag acctaaaacc ataaaaaccc 3000
tagaagaaaa cctaggcaat accattcagg acataggcac gggcaaggac ttcatgacta 3060
aaacaccaaa agcaatggca acaaaagcca aaatagacaa atgggatcta attaaactaa 3120
agcacttctg cacagcaaaa gaaactacca tcagagtgaa caggcaacct accgaatggg 3180
aggaaaatgt ggcaatctac ccacctgaca aagggctaat atccagaatc tacaaagaac 3240
ttaaacaaat ttacaagaaa aaacaacccc atcaaaaagt gggcaaagga aatgaacaaa 3300
cacttctcaa aagaagacat ttatgcagcc aacagacaca tgaaaaaatg ctcatcatca 3360
ccggtcatca gagaaatgca aatcaaaacc acaatgagat accatctcac gccagttaga 3420
atggtgatca ttaaaaagtc aggaaacaac agatgctgga gaggatgtag agaaatagaa 3480
acacttttac actgttggtg ggagtttaaa ctagttcaac cattgtggaa gacagtgtgg 3540
caattcctca aggatctaga actagaaata ccatttgacc cagtgatccc attactgggt 3600
atatacccaa agatcataaa tcatgctact ataaagacac atgcacacgt atgtttattg 3660
caacactgtt cacaatagca aagacttgca tccaacccaa atgtccatca atgatagact 3720
gaattaagaa aatgtggcac atacacacca tggaatacta tgcagc 3766
<210> 227
<211> 938
<212> DNA
<213> Homo sapiens
<400> 227
ctggcactct gctcattttt ctttgcaccc tttattttat atgtgcttta ttatgggtcg 60
tttctatgct gggacttcac agtgttgaat ctgccattaa tcccacccaa tgtatctttc 120
atgtcatatg ttatatagct ctcaactgca gaattttgac ttaggtcttt tgtatcgcat 180
ttggcatgtt tggtcttttc tctagcttct tcaacatgtg aaattgttac tctcttttaa 240
tgtccttggg tactaattct atcgtctgtg tcatttcttg gaaattttca actggctgat 300
ttttttcttc attatgggtc atattttcct gcttcttagt atgcctggta attctttatt 360
ggatgccaga cattgtggac tgggtggata tttttgtatt cctaaaaata ctcttgagtt 420
aagttacttg gaaatagttt gaccctttcg agtcttgcct ttaagcttta tttggcagga 480
acagaacagc atttactctc rggctaattt tgctttacta ttgaggcaaa acctttcagt 540
actataccca atgcccataa attataaagt tcaagaacag gcaaaactat gccaatagaa 600
atcagaatag tgattgacgg tagggtgtgg atattggaat tttctggggt attgcttaca 660
caaatgtacc tattaaaatt catcaaactg ctcaaaatct gtgcatatca ctgtatatca 720
attttacctc tataaaaatc atgtttggta tcaaatatat gtgtacataa ttaaatgctg 780
aaaagattta tactaaaatt tcaatagtga agaatatcag gtagttttct aattggcttc 840
tgaatatttt catgttatct aaattttcaa tatatataac cttttaaaaa tacataaaac 900
taatatttaa tgaaacaatt taagggggac tctctacc 938
<210> 228
<211> 401
<212> DNA
<213> Homo sapiens
<400> 228
acaatataac aactctatca agtaggtatt atcccatttg caaaagagaa aacagtgatt 60
cagacttatg gttatgtgtc caaggaccct caacttgatc ttaggtctgc ctgcttctga 120
agtcggtatt ttgattctaa gagaattaag ccctcaagac ggatttctga aattcagaga 180
gtaaagaatg cttggtagga yagaagaatc ccagaaatac attactgtct acgagcatag 240
gaattggcac attggactct gggagttaac tattaaaatg ggaaagtgaa ttatccaaat 300
gtcagagtca caaatcaagc acagttaatc tgaaacccaa gaaagtctga cctgagacaa 360
ggaaagaggt gggtggctca gaggaaaaaa aaaaaaaaaa a 401
<210> 229
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 229
gggctgtggg agagcacacc catgaggttg ctcagggagc aatgggccac agcagttttc 60
cctgtgaatt gtgttcaggt aagaccctgc agtcagacca gctcactcct cctttgctat 120
ttctttatat atagtctctt tccattccga aaatgtactc tgagccctgg cctttaacag 180
cttcatttgt tttccttcat ctcccagttt acaactgtga aggaaacatt cattgatcaa 240
gttctttcag cttggaatgg agtctctgac tcccaaaaat ctctcccagg accaactgca 300
agggggtagt ggatctagga ttaaggctgg agcctgaagc actgctgaga atggggagtc 360
tgacacgtaa tgacctccat atatacaagc tggtcagtgc tctctcagag cctgcatgtg 420
gctttgtcca gagaatatga atcccagttt gagcagcaat atggatcaga gttggtagag 480
aggaagattg aggctctcac vctaggatgt cttcagcatc cttcttgtat ccttgtgtgc 540
aaaatgggag cctgggaaag gaactagaag aactgaaccc catccctctg atacatacac 600
attgcttttt tccttcttta tagcatagct tggctgtcca aatgttctgg cagagaccaa 660
gctccaggct cagtgggggg ttctaatttt ccatggctca ttcacttctg agaactttgg 720
ctcagttgca taatgggggg ctacttcctg ccagttgtgg ccctgttgtg tgataccttc 780
tgacacatac gtttttttga aaaaagattg tctgctggga actggactga aaccaacata 840
taaccgtttg tttcatactg gttaggaagc caccaggaag gcctacccaa agtggtttta 900
aatacataca cacacagtcc tctcctctta gagccaagaa caggccatta gtgatgtgtt 960
agaaaatcca ggctgacctt ctcagtcatg agggaagctc c 1001
<210> 230
<211> 501
<212> DNA
<213> Homo sapiens
<400> 230
cacacagtcc tctcctctta gagccaagaa caggccatta gtgatgtgtt agaaaatcca 60
ggctgacctt ctcagtcatg agggaagctc cctgggccca ccagcaggct tttgccaaga 120
atgggctcca tcttgagccc acagctcttc cctagcttcc cagcagaagc aaggggagag 180
tggagaagtc aaacacttct tgagcattgc ttactatatg tcaagttcta ccctggaccc 240
tcaatagaaa statttcact gatcctcaca atagatctgt ggggtaagtg tcactattgt 300
tattttgagg aaactgaggc tcagaaaagt tacatgtatt cccaaagtca catagtaaac 360
tgagtgtgta aacttgagtg gtagagtcag aatttaaaca ctgattttta tctgttgcaa 420
atgttgggct tttcccacca ccagcagaaa tcttgctggc cctcagcaaa tattccttta 480
cagcagtcat ttcaaaactt t 501
<210> 231
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 231
cttagagcca agaacaggcc attagtgatg tgttagaaaa tccaggctga ccttctcagt 60
catgagggaa gctccctggg cccaccagca ggcttttgcc aagaatgggc tccatcttga 120
gcccacagct cttccctagc ttcccagcag aagcaagggg agagtggaga agtcaaacac 180
ttcttgagca ttgcttacta tatgtcaagt tctaccctgg accctcaata gaaagtattt 240
cactgatcct cacaatagat ctgtggggta agtgtcacta ttgttatttt gaggaaactg 300
aggctcagaa aagttacatg tattcccaaa gtcacatagt aaactgagtg tgtaaacttg 360
agtggtagag tcagaattta aacactgatt tttatctgtt gcaaatgttg ggcttttccc 420
accaccagca gaaatcttgc tggccctcag caaatattcc tttacagcag tcatttcaaa 480
acttttctga ccctatactc ycatcagtaa acatttttaa gaaccacctt caatacagac 540
atatttattt atttataaac tccacgcact agctaatatc tgttagcatt gcctggtaat 600
ataatacccc agagcactaa tcatcattaa tgacaataaa tatatatcca tgtttaatgt 660
agtcttcatg acttggaaaa ctttttggcc agatcttgtg aaatctaatt aaattgcttt 720
tgttttagct tcaatacatg gctggcaaat aatttgttcc aggagtagaa gaaatgatat 780
ggcattcttc ttaccttctt gggcatgagt tgctcctgct gtcaacaatc tccagtttcc 840
ttacagaaga atttttaaga cacttttcca ttttttaaaa gtgattcggt taaaatggga 900
taatatggtt tgtaaatcga ctcactgtgt ttatgcaaga ccatggaata ctatgcaccc 960
atataaaggg atgagttcat gtcctttgca gggacatgga t 1001
<210> 232
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 232
atttttatct gttgcaaatg ttgggctttt cccaccacca gcagaaatct tgctggccct 60
cagcaaatat tcctttacag cagtcatttc aaaacttttc tgaccctata ctcccatcag 120
taaacatttt taagaaccac cttcaataca gacatattta tttatttata aactccacgc 180
actagctaat atctgttagc attgcctggt aatataatac cccagagcac taatcatcat 240
taatgacaat aaatatatat ccatgtttaa tgtagtcttc atgacttgga aaactttttg 300
gccagatctt gtgaaatcta attaaattgc ttttgtttta gcttcaatac atggctggca 360
aataatttgt tccaggagta gaagaaatga tatggcattc ttcttacctt cttgggcatg 420
agttgctcct gctgtcaaca atctccagtt tccttacaga agaattttta agacactttt 480
ccatttttta aaagtgattc rgttaaaatg ggataatatg gtttgtaaat cgactcactg 540
tgtttatgca agaccatgga atactatgca cccatataaa gggatgagtt catgtccttt 600
gcagggacat ggatgaagct ggaaaccatc attctcagca aactaacaca agaacagaaa 660
accaaacacc acatgttctc actcataggt gggagttgaa caatgagaac acatggacac 720
aggaggggaa cgttacacac cggggcctac cagggggtgg tgggctaggg gagggctagc 780
attaggagaa acatctaatg tagatgatgg gctgatgggt gcagcaaacc accatggcac 840
ctgtatacct atgtaacaaa cctgcacgtt ctgcacatgt atcacagaac ttgaagtata 900
tatatatata tatatataaa acaccataat atgctaaaag agaaatcagg gcaccagtag 960
gacctccccc acccaccttg cagaatttca ctttcctcac a 1001
<210> 233
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 233
tgagttgctc ctgctgtcaa caatctccag tttccttaca gaagaatttt taagacactt 60
ttccattttt taaaagtgat tcggttaaaa tgggataata tggtttgtaa atcgactcac 120
tgtgtttatg caagaccatg gaatactatg cacccatata aagggatgag ttcatgtcct 180
ttgcagggac atggatgaag ctggaaacca tcattctcag caaactaaca caagaacaga 240
aaaccaaaca ccacatgttc tcactcatag gtgggagttg aacaatgaga acacatggac 300
acaggagggg aacgttacac accggggcct accagggggt ggtgggctag gggagggcta 360
gcattaggag aaacatctaa tgtagatgat gggctgatgg gtgcagcaaa ccaccatggc 420
acctgtatac ctatgtaaca aacctgcacg ttctgcacat gtatcacaga acttgaagta 480
tatatatata tatatatata waacaccata atatgctaaa agagaaatca gggcaccagt 540
aggacctccc ccacccacct tgcagaattt cactttcctc acagtgcttc gcacggatgc 600
aaatgactcg tgggagtctg agggtaccgg ggtccatata tacattcaat attagtacat 660
agaaaagtag ttcccatttt tagattgaaa gtacctatga atagaagctc taatggtttc 720
ttcccttatc tcgtgttcta ttctgcgcaa ttcctggagc gggcagtccc cgccttggag 780
actcctgcct tacaggaagg ggtcacatat tcctgaattg gaccccactc agatgcagaa 840
ggctaagagt ttggatgaga aaagcgggcc agtgaacagg agagccggtg ggtggggtgg 900
atggaaggag gtgcccactc tggagggcaa gagaaaggca cgaaagcatg gggccacatg 960
agcgcggcgt tctgggccat ccccggtgga ctcctgccta g 1001
<210> 234
<211> 1274
<212> DNA
<213> Homo sapiens
<400> 234
cagagcacta atcatcatta atgacaataa atatatatcc atgtttaatg tagtcttcat 60
gacttggaaa actttttggc cagatcttgt gaaatctaat taaattgctt ttgttttagc 120
ttcaatacat ggctggcaaa taatttgttc caggagtaga agaaatgata tggcattctt 180
cttaccttct tgggcatgag ttgctcctgc tgtcaacaat ctccagtttc cttacagaag 240
aatttttaag acacttttcc attttttaaa agtgattcgg ttaaaatggg ataatatggt 300
ttgtaaatcg actcactgtg tttatgcaag accatggaat actatgcacc catataaagg 360
gatgagttca tgtcctttgc agggacatgg atgaagctgg aaaccatcat tctcagcaaa 420
ctaacacaag aacagaaaac caaacaccac atgttctcac tcataggtgg gagttgaaca 480
atgagaacac atggacacag gaggggaacg ttacacaccg gggcctacca gggggtggtg 540
ggctagggga gggctagcat taggagaaac atctaatgta gatgatgggc tgatgggtgc 600
agcaaaccac catggcacct gtatacctat gtaacaaacc tgcacgttct gcacatgtat 660
cacagaactt gaagtatata tatatatata tatataaaac accataatat gctaaaagag 720
aaatcagggc accagtagga cctcccccac ccaccttgca gaatttcact ttcctcacag 780
tgcttcgcac ggatgcaaat gactcgtggg agtctgaggg taccggggtc catatataca 840
ttcaatatta gtacatagaa aagtagttcc catttttaga ttgaaagtac ctatgaatag 900
aagctctaat ggtttcttcc cttatctcgt gttctattct gcgcaattcc tggagcgggc 960
agtccccgcc ttggagactc ctgccttaca ggaaggggtc acatattcct gaattggacc 1020
ccactcagat gcagaaggct aagagtttgg atgagaaaag cgggccagtg aacrggagag 1080
ccggtgggtg gggtggatgg aaggaggtgc ccactctgga gggcaagaga aaggcacgaa 1140
agcatggggc cacatgagcg cggcgttctg ggccatcccc ggtggactcc tgcctagggg 1200
aggggtgcgt cggcggcggc agcccagttt tctggatttc tttatttctg agtccaggtc 1260
tttcagaagc ctct 1274
<210> 235
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 235
tgggagctcc agagtgggcg aggacttcgg gcagacccgg cgttgctgtt ggacatcatt 60
cagaagtccc cgctcagcgg gggcagcccg aagagcaaaa caaacagagc gaggagtagt 120
ggaaaatgct gagtcctgga gctggccgga acggccttcg cctttccacg cccaaagcca 180
gccgctctgc ccacctgcag ctgcaatagc aagcagggcc gcagcaggca gggaggcctt 240
ggcaccagag cccgtccagg gctgggaagg cggggaacag acactcctct ctcttcagac 300
aggccctcca gagtcctcac cctgaaggct gaggtctttt tcttgttcca ggagtccagt 360
gaaaaaatag ttctcaaaaa cggagaaaaa gactttcttg aactgcagtt tcagatttac 420
taatagagtc catttacata gcacttacta aatgtcaagc accaacacag atgaattggc 480
aatcaccatg tcagtcctgc raggttggta cttttatccc catttcacag atgaaaaaag 540
ccaggcacag agaagtcaaa taacttaacc caagttcaca atgctcaaca atggcagggc 600
caggatttac cacctggttt aaaatttaaa acgtaggatt taaaacctac tttacagtct 660
taaaggtgac tgccttttct cttcagctta ttagatttcc tctctaggaa tacaagatgt 720
gcaacacaaa gagaggaaac tcaagatgga gagtaaaggg aatgaatgag agacaggaga 780
atcaccaagg actagaataa tacaaaagat ttatttaaaa agcaggtggc catcggccca 840
ggagaaggag tgtgagacca aggtacagaa gtggcaagaa atgctgagct ggggctggaa 900
ggtatgacag tactagtcag acaggcacct gttctgtcca aaacaggatt ccagaagtaa 960
tgtgaagagg tcacttggca aagggggctc acacagctct a 1001
<210> 236
<211> 501
<212> DNA
<213> Homo sapiens
<400> 236
ccattcctct aagccaagag ctcttgtccc cagaggaaag aggagaagga agaaaggaac 60
aaacaaatga acagaggaag gaatgaagag agagagagag aaggagggag gaagggctgg 120
aaggaagaaa ggaaggggct gttttttttc ttgtgtttgg aagaacaagc tgccaaccct 180
cattaaatgc ataggattgg ctttagagtt actacaccta aattctaatt ctgtctctgt 240
caccggttag yaatgtgatc tcatggaaat cactgaaact cccttaacct gaaaccccat 300
gtctatacaa tgaggacact ggaattcacc tctaaggttc tctctggatc taaaatctac 360
actctgatga tactgagacc aaggacaggg actttgattg ttgccttttc atgccaccca 420
aggtctacat cctagcacag tgcccaccac ccatccacac cgaccagaca cccagggcta 480
gtgattctgt gttctcaaca c 501
<210> 237
<211> 401
<212> DNA
<213> Homo sapiens
<400> 237
ctggcctttg ttgattccct aggttgctgt gggcagatga tcatcgccat cattactttg 60
gatgtcagga cattgagata caccaggcaa tctgatgcaa ctggctttcc cagggcagaa 120
gcatttgcca ggaaagtgga aacagggaaa gggactggaa cattgagtaa atcaggaaat 180
agcactgacc aagggacaga raggccagag ccactttacc ccctcatttg gggttctaaa 240
ttcttatcaa attttttttc ctcaagttca aaccttgtgg cattttcacc aattgatcaa 300
caactgcctt tatcagactc cttgaatctc tgcctcactg caaaaagtgc caggggaatg 360
cttttctctt ctattattta ggtgaggatt ctcacggcat g 401
<210> 238
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 238
ggcagatgat catcgccatc attactttgg atgtcaggac attgagatac accaggcaat 60
ctgatgcaac tggctttccc agggcagaag catttgccag gaaagtggaa acagggaaag 120
ggactggaac attgagtaaa tcaggaaata gcactgacca agggacagag aggccagagc 180
cactttaccc cctcatttgg ggttctaaat tcttatcaaa ttttttttcc tcaagttcaa 240
accttgtggc attttcacca attgatcaac aactgccttt atcagactcc ttgaatctct 300
gcctcactgc aaaaagtgcc aggggaatgc ttttctcttc tattatttag gtgaggattc 360
tcacggcatg gagggatctc acagagtagt gagatgccag cagcatgccg agccaatatg 420
cccataaatg caagggccag gtccttaatc cagccatgag gatggtcaag gatccctgta 480
tacaagccag agaagggact ytgtacaact agaactgagt cgcaaaccat cttccagagc 540
agcccctggg gaaaagcaga ggccaaacag cagtatggaa gtgaaaaggc tcacgtactg 600
aaagaagact ttgtccttgt cccatatttg atgtgtgaaa cgtacccctt agtaaccagg 660
cctgtggctc ccagagctgg tgagccatca gccagcatca tcaaaagaga cttttcagcg 720
ttctatgcca gcaatacggc atcatggaaa gaacagggct tagaagtcag atggttctct 780
gatgaacctg atgacctctt gtactctctt ccaccgtagg ctctagaata aaatgagctt 840
catgccaagt aaacatggaa tgtggataga tatctacaca ggggtcacaa aattaaattc 900
tacagggaca aggcaggaat gtcaatgtgt gggcctgacc tatgagagtt aaaatagggg 960
actgatatgc acctaaagga ggcagcttca gttcagtgcc c 1001
<210> 239
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 239
gatgcaactg gctttcccag ggcagaagca tttgccagga aagtggaaac agggaaaggg 60
actggaacat tgagtaaatc aggaaatagc actgaccaag ggacagagag gccagagcca 120
ctttaccccc tcatttgggg ttctaaattc ttatcaaatt ttttttcctc aagttcaaac 180
cttgtggcat tttcaccaat tgatcaacaa ctgcctttat cagactcctt gaatctctgc 240
ctcactgcaa aaagtgccag gggaatgctt ttctcttcta ttatttaggt gaggattctc 300
acggcatgga gggatctcac agagtagtga gatgccagca gcatgccgag ccaatatgcc 360
cataaatgca agggccaggt ccttaatcca gccatgagga tggtcaagga tccctgtata 420
caagccagag aagggacttt gtacaactag aactgagtcg caaaccatct tccagagcag 480
cccctgggga aaagcagagg ycaaacagca gtatggaagt gaaaaggctc acgtactgaa 540
agaagacttt gtccttgtcc catatttgat gtgtgaaacg taccccttag taaccaggcc 600
tgtggctccc agagctggtg agccatcagc cagcatcatc aaaagagact tttcagcgtt 660
ctatgccagc aatacggcat catggaaaga acagggctta gaagtcagat ggttctctga 720
tgaacctgat gacctcttgt actctcttcc accgtaggct ctagaataaa atgagcttca 780
tgccaagtaa acatggaatg tggatagata tctacacagg ggtcacaaaa ttaaattcta 840
cagggacaag gcaggaatgt caatgtgtgg gcctgaccta tgagagttaa aataggggac 900
tgatatgcac ctaaaggagg cagcttcagt tcagtgccca tggtggttgc tatgaaggaa 960
tatgctagaa tccaaagaca tcccattaac ctactacggt a 1001
<210> 240
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 240
ggtctgacaa ggccagggac attccacaaa ggatgacaca atatattcaa agattgggat 60
gttcgatgac ttccctatat tcctgttata tttctcacct tattaggaaa tctttatctc 120
caatggtcct gagctagtga gatcagaaag actaaactgc atccctctgt gcttgcctct 180
ggttggttga tttgtcctgc tttaatacat gatccagaca agaaagaatc aagccaaagc 240
cacagcatta tgaatgaaat tctttgtttt taatttcaca cagtttaaaa tacaatatga 300
aatcaggcta cagtatataa aaaactctcc agcaaaatga tgtgccagca tcagctacta 360
aaataaacaa acaaaaaact ccgccataag aatttttttg catttttttt taaaaaaaca 420
tcgacactta catcgctaca tctctaagct acctcagttc tgatttttaa aaagcacctg 480
cttttccttt ttttcatctt rcttctaaat tttcagcttt taaaaaatat aaattatatg 540
aaaatacaag ttggaaaata gtcaaacaca atataacatc tttttcatcc ctatacttct 600
cagcttaaaa aaaaagtatt cttaaaaaaa aaagttcaat aactgaggca gtattcctga 660
taattttatt ttaatatata tattttatat atgtatatgt atacatatat ttatggttcc 720
ttgaaacttc tttggaatgt aggtaagagt tcaacaaatt tatatagacc ccaacagagt 780
aagcggcatg cacagcatga ctagaagaga gatggtgtat ttctcaccat gaaggttagg 840
caggttaatg ctgtaaaacc cagagtgttc atctccaaag tgaggaaaag cacatctgat 900
ctttgaatgc tacctccaat ccccacagcc acaaaaatca gggctctatg taggggaagt 960
ccctctccag aatggagaag ggaacaaaag tgactctgaa c 1001
<210> 241
<211> 401
<212> DNA
<213> Homo sapiens
<400> 241
aattttattt taatatatat attttatata tgtatatgta tacatatatt tatggttcct 60
tgaaacttct ttggaatgta ggtaagagtt caacaaattt atatagaccc caacagagta 120
agcggcatgc acagcatgac tagaagagag atggtgtatt tctcaccatg aaggttaggc 180
aggttaatgc tgtaaaaccc rgagtgttca tctccaaagt gaggaaaagc acatctgatc 240
tttgaatgct acctccaatc cccacagcca caaaaatcag ggctctatgt aggggaagtc 300
cctctccaga atggagaagg gaacaaaagt gactctgaac cctaaagcca aaaccaacaa 360
aggttaaggc atctctggga aaataagggt ttcacccagc t 401
<210> 242
<211> 601
<212> DNA
<213> Homo sapiens
<400> 242
acattagtct ctttctctgt taagccagag ccttcaagct tctgagaagg cccttctccc 60
tctcctgaaa atttgctcaa gaatttctgg tcccacccac cccacaagtc ctggctttcc 120
tttcccaact gcgcacaatt gattacagct gcaactgact tagctcccac ccctgaaggt 180
aaaaaatgag ttctggaaaa taaaaaatag aataacaatt caaaattcag agtccaacca 240
acacggctgt ccttggaagg tctcagcagg gtttccccag ccccttcagt gccatcactc 300
rtcggcatct ggcttgacgt ccagcatggc gtgcagctcc tcaggggtgt accccagcag 360
gctctgcagg tcacacacaa agcggtacac gtagcgtttc cccgctgtct tgtggatgat 420
gtttttgtcg taatagtagc gtaggccacg gctcagtttc tcataattca tcttaggttt 480
gtttttcctc tttccccatc tcctggccac ctgaaattta aaaagaaaaa taaaggagga 540
gtaggcaaaa atctacaaga caggccaaat atatatgttt ctatgcctat gctataccca 600
t 601
<210> 243
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 243
atacccattc atggtgaccc atgatgctca agtaagatga tttgagattc atgtagatat 60
agaaaatatt tttcgggcct atctcctgaa ttccattttt catgggttgg gcaaggatgg 120
gagtcacaat gattctttaa gttgatgaaa acacagtgac cctgaactag gattaaatat 180
gtgactttaa aaaacaaaca aaaagccaca ctatacattc tcctctttcc gcatattatt 240
agtaaaatct ccttgctttg caagcatgaa atctaacagg gaagtgtgaa gcggaggagc 300
tgagctgcaa tcatacctgc ctttcatcaa caggaagtgt tttttttcca taccagggca 360
caaatatttt ctcatgtctg ccagaacaaa gatgttgtct ctcctgttca ttgtttttta 420
tcctcagaat tgggcatggc acggaaccac tactccataa acatgtgtgt aatgaaataa 480
gaaactaatg agccaatctc ycaaggcctc ttgaactgtc tggccccttt cacactcaca 540
gagccaccgg gctaggaaga ggctaagtca caggaggcag ctctatgggt gataactgac 600
ctactgccag gcacgttaat gccttctatc agctaatcct gtaagacaaa tggggtaaca 660
tagatctttt ctctattttc caaataatga acctggagct cagacaggct acctagcttg 720
ctccgggtgg caagtggcag agctgggaat cccaatcctg gaacacgtca ttcaggccca 780
cgccacccct tccaggagtt ttctctcatc cttcctcaac acagtactcg caagcccctc 840
cttccttacc tcatctgggt cagaaagttt gaattcccag ccatctcctg tccagctgat 900
aaaagactga caggatttat cagtgagtaa ttccagaaga aactgccata gctggattgg 960
tccactgcct agaaacacaa gccattgtga atcattacac c 1001
<210> 244
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 244
cacaaatcag gggccacagg ctccctacta cagagcagtg cttatgagcc ataacttgtg 60
tttggaactg gcaaagacat tcattccttc gttaatatgt ttcttacttc tgaaggcaaa 120
aataatgact tagtttttgc aggtgtaaaa gattatgctg ccttagaata tcccagagga 180
taggcacagt gttctctttc tagaatttgt ttagcaataa aaatgaaccg atccttaagt 240
taatcaaaat aaagcacttg acacattttc ttccatgctt ttgttttata gggaggcctt 300
tgtcttttct atctgttcga gctcataaca cttcctccga catgtgcact gtctgttgcc 360
ttcattttct cctggctgga tgggctgaga gaagagggat gtgggagtgc cgtgtgtggg 420
gattagctgc gtagagtgct gaatatctgg tgtaatgatt cacaatggct tgtgtttcta 480
ggcagtggac caatccagct rtggcagttt cttctggaat tactcactga taaatcctgt 540
cagtctttta tcagctggac aggagatggc tgggaattca aactttctga cccagatgag 600
gtaaggaagg aggggcttgc gagtactgtg ttgaggaagg atgagagaaa actcctggaa 660
ggggtggcgt gggcctgaat gacgtgttcc aggattggga ttcccagctc tgccacttgc 720
cacccggagc aagctaggta gcctgtctga gctccaggtt cattatttgg aaaatagaga 780
aaagatctat gttaccccat ttgtcttaca ggattagctg atagaaggca ttaacgtgcc 840
tggcagtagg tcagttatca cccatagagc tgcctcctgt gacttagcct cttcctagcc 900
cggtggctct gtgagtgtga aaggggccag acagttcaag aggccttggg agattggctc 960
attagtttct tatttcatta cacacatgtt tatggagtag t 1001
<210> 245
<211> 401
<212> DNA
<213> Homo sapiens
<400> 245
tcaacactct gacagtcaat ttattctatg ctaaaaggtt tatatcacac cgatttcctt 60
tgaggatact tttctcatct gaaatgacaa tgccaccagt gattcttaat ttataggtgt 120
cggtggagag acaaataggg gttcaaaagt ccatgcttct tgttacactg ccccttataa 180
cataaacaaa ctgggcagag ygggactggg aaagacccag tccatgtctc tggatacagc 240
ccaggaagca ccagctccta caggaaagct ttgctcacta aggctctaat ttttcaccgg 300
agttgcaaat ttgtctgatc caaagtaaac tgagatttaa caggaaacaa actttaagtt 360
ccctctcaat ctaaaaaaga aattgccttc ataatccata a 401
<210> 246
<211> 601
<212> DNA
<213> Homo sapiens
<400> 246
ggcaacctcc aatgaagtaa agaaacagct actgacacga gctatcatcc cacagccaaa 60
ggaagtcctc ctccagtaac aacttcctaa tggtggtttc caaggctcct ctcagcactt 120
gccacgctaa atatgaaaac atgaaatagc tctacctcct ctttctgaga atggaccatt 180
agctctttaa aactatcttg caagaaatac cttacatgta ttccacaata aaatggctca 240
gtgaatgcct ataaaataaa gtaacattcg aacaacagcc cagagggccg cactggtaaa 300
dccgtagctt cctctgtttc tactttcatt caataaaaac cgtttcgtat tcaactcagg 360
gacatttgca ggtttcttgg gagttgccta aagtcatgag ctacttgttt tctgcctggg 420
ctcacaaaac taaccgtgac attctcagag gaatccactg agaagccatc ctaacaggca 480
caaagaagta aaacagcaaa tcgctctcaa gaaatgcagc tgccagagcc ctggtcacag 540
aataggtttc ttggagaaac tcacgataac tatagagact gaagagagac atgaagaaaa 600
c 601
<210> 247
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 247
accttacatg tattccacaa taaaatggct cagtgaatgc ctataaaata aagtaacatt 60
cgaacaacag cccagagggc cgcactggta aagccgtagc ttcctctgtt tctactttca 120
ttcaataaaa accgtttcgt attcaactca gggacatttg caggtttctt gggagttgcc 180
taaagtcatg agctacttgt tttctgcctg ggctcacaaa actaaccgtg acattctcag 240
aggaatccac tgagaagcca tcctaacagg cacaaagaag taaaacagca aatcgctctc 300
aagaaatgca gctgccagag ccctggtcac agaataggtt tcttggagaa actcacgata 360
actatagaga ctgaagagag acatgaagaa aaccattcta tcccaaagct atgtaaaaga 420
agcctcggag gagagggggt tgccttagac cctgacagag aaaaactaat gagtgctatg 480
cttgacggtg cacctactac rccgcagaca ctgtgagtga cgctctacac tcgtttcctt 540
cattcctccc aataattctg tggggtggat gcaactgttg tgctatttgt ttctaccact 600
tcacagcaga gaaaactgac acactgcaag gccatttaga tcagcagtgg agtagccggg 660
actggaaccc atgcagccca tccccaggtt cttcatctca atgctacgtt gcccctggac 720
aggaccaggc caaaggcctg gcatctaaac tgcctgactg agtgcaatgt tccaagggat 780
aaggggacct gacttgaaaa actctctccc ctacttctca cagcagttgc aggacacggg 840
atagccagtg gttctcccag tcatccgacc accagtggcc gtgccaggcc ccgccatggc 900
atccacctcc acaggagata tttccagcat cctcttgtgg tagccattat gttacattac 960
ttcattgttt ctccttccca atgttcacct ttgaacctct c 1001
<210> 248
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 248
cagtcatccg accaccagtg gccgtgccag gccccgccat ggcatccacc tccacaggag 60
atatttccag catcctcttg tggtagccat tatgttacat tacttcattg tttctccttc 120
ccaatgttca cctttgaacc tctctcccac tatctgaaaa tctctttggg gcacggggtc 180
tcatgacacc aagccgagga aagggatggg aagatcgaga tccttccccc ggatgagtct 240
ttggcaggga gctgtcagca catctgctgg tgctggagaa cagggcccag gagcacactg 300
cagtctcctg cccttgggac ttggcagcca caatgcagag aagggacctt caattcccgt 360
ggtttgcacc agctcccaga ggacgaaccc tctgacggaa tggttagttt tccttttcta 420
ccagtgcatt ttccaaactg aaatgtcaag cagtcatagg ctgtagatgc cctgccctgc 480
cctttctctg tgatgtcagc rtacgggacc cggtgagtct gggacagggt gagtactcgt 540
cagaggactt ttgtcctcat tgtgactttt cctttgttca aaaggaatga aagaaaaaaa 600
aattaaattc aggccctaga agcccaagtc ctaggtgcag agctctctaa ctcttttttt 660
tttctgttta cacccaagga aagagggagg atagatagga aaagcagata cctaaagaaa 720
taatgggaat atgaatggga agaaatctct cccgttggct tcataatagg acagtcaaca 780
taacagagat gtcagttcct ggctccctcc cccgattcct gtagagaaac cccacaggcg 840
cactccagcc taactggtgc acacagggct cacccttcag aaagcccaca tttttgtacc 900
aagtgagagg agttcatgat ggccgctgaa gcgtcccctc tagcaccttt ttgctgactc 960
ctaaactgcc tttttgttgt ggggagcaag agaactagga a 1001
<210> 249
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 249
tctctcccac tatctgaaaa tctctttggg gcacggggtc tcatgacacc aagccgagga 60
aagggatggg aagatcgaga tccttccccc ggatgagtct ttggcaggga gctgtcagca 120
catctgctgg tgctggagaa cagggcccag gagcacactg cagtctcctg cccttgggac 180
ttggcagcca caatgcagag aagggacctt caattcccgt ggtttgcacc agctcccaga 240
ggacgaaccc tctgacggaa tggttagttt tccttttcta ccagtgcatt ttccaaactg 300
aaatgtcaag cagtcatagg ctgtagatgc cctgccctgc cctttctctg tgatgtcagc 360
atacgggacc cggtgagtct gggacagggt gagtactcgt cagaggactt ttgtcctcat 420
tgtgactttt cctttgttca aaaggaatga aagaaaaaaa aattaaattc aggccctaga 480
agcccaagtc ctaggtgcag rgctctctaa ctcttttttt tttctgttta cacccaagga 540
aagagggagg atagatagga aaagcagata cctaaagaaa taatgggaat atgaatggga 600
agaaatctct cccgttggct tcataatagg acagtcaaca taacagagat gtcagttcct 660
ggctccctcc cccgattcct gtagagaaac cccacaggcg cactccagcc taactggtgc 720
acacagggct cacccttcag aaagcccaca tttttgtacc aagtgagagg agttcatgat 780
ggccgctgaa gcgtcccctc tagcaccttt ttgctgactc ctaaactgcc tttttgttgt 840
ggggagcaag agaactagga aagacatgga aatgttcttc cagccagaaa cactgggcca 900
gggtgggcgc agttcctggc tgggcccgtg gatggtctaa tacaggagcc tgtctccaca 960
gcaatgcatc accctcactt caggtctggg aggggacttc a 1001
<210> 250
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 250
tcagtgacct ttgtccccta gagcagaaaa cggtactaat aatagcgcca gtcatgggaa 60
ggggagctca catgttcaat gtgactcata atggtgtccc tgtctgggat ctccaaggca 120
gtcaacagca cccttcacga tgctgcccgg gagtgtcaca catcaggaat ccagtggcat 180
cactgggaaa gtatgcttct caagtcgaag ctctgagcca caacaacaga ggggtccctg 240
ttagaaggag gtctctttcc agagccatgc gggcgggaga gcaccacaca cacactccac 300
acacccatct cccatggcac ggagcctcca caccccctgc tgtctgctcc ctctccaccc 360
tccctctcag gcggctgcag gggaatttcc ttctactgct ttgttcttct cagcctctgg 420
agaagaggac agttcttact acacactgac aggtctgatt tgaagaacgt gctacaagct 480
ctgaagaaga aataccaggt rggaacttgg agagctccca agcctacaaa gcaaatcaca 540
ccaaggatgt tcacccccta aggggacccc caaggctcct caaatctaag gcaacaatct 600
cactttttaa aaaaagtaaa gcttcaagta aattactgct catttgggtc atatttcctt 660
gtctgggagc tgcaaggccc actatctgtc tcaatgagga gctggttatt aaaaatcccc 720
tgctattctg gtcccttgcc ctgaggctga gaactgagca gcataaatac atatatagca 780
atgggctagg acaaggtgtt agtaacatgc tcttgatgga aatcccttcc atttcccgat 840
ttgtcagtat cattcttctc attttccaga tctgggagtt gcctgcctgt gacaaggaca 900
tcctcacagc aagtgaacag ggtcaggttg aacttcactt tttccttcta ctccttcctc 960
atttccattt caaccacaag ttctcactct tgtcacctgt g 1001
<210> 251
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 251
tcacgatgct gcccgggagt gtcacacatc aggaatccag tggcatcact gggaaagtat 60
gcttctcaag tcgaagctct gagccacaac aacagagggg tccctgttag aaggaggtct 120
ctttccagag ccatgcgggc gggagagcac cacacacaca ctccacacac ccatctccca 180
tggcacggag cctccacacc ccctgctgtc tgctccctct ccaccctccc tctcaggcgg 240
ctgcagggga atttccttct actgctttgt tcttctcagc ctctggagaa gaggacagtt 300
cttactacac actgacaggt ctgatttgaa gaacgtgcta caagctctga agaagaaata 360
ccaggtagga acttggagag ctcccaagcc tacaaagcaa atcacaccaa ggatgttcac 420
cccctaaggg gacccccaag gctcctcaaa tctaaggcaa caatctcact ttttaaaaaa 480
agtaaagctt caagtaaatt mctgctcatt tgggtcatat ttccttgtct gggagctgca 540
aggcccacta tctgtctcaa tgaggagctg gttattaaaa atcccctgct attctggtcc 600
cttgccctga ggctgagaac tgagcagcat aaatacatat atagcaatgg gctaggacaa 660
ggtgttagta acatgctctt gatggaaatc ccttccattt cccgatttgt cagtatcatt 720
cttctcattt tccagatctg ggagttgcct gcctgtgaca aggacatcct cacagcaagt 780
gaacagggtc aggttgaact tcactttttc cttctactcc ttcctcattt ccatttcaac 840
cacaagttct cactcttgtc acctgtgctc tgctgagagg agaacacagg agttttcttc 900
caaacagaag gaggtcaacg ctgggcaggc accttcccag gcagtctcct catatttcca 960
tagtacatgg cttacaccaa gaccacccca ttggtttggt c 1001
<210> 252
<211> 501
<212> DNA
<213> Homo sapiens
<400> 252
ggattagaaa gtccgctcaa atggcttctc tctattaaac aatatttggg gccaaacaat 60
atgggtgacc ctcaggctgc atttcatcaa cgtgttccca aaaatgaaaa tgactacctg 120
tcctttggga gttaatttgc tactttaaga agctaatccc tttagctcta ttctaaaagt 180
caaatcaaat acctcggtgt gggcaggaca ccacatttat tttaacctat gaaactctca 240
tggttggtca mccttgcaat agggctgact ctgccctgat agcacacatc tggcaggtgg 300
ccctaaaaca gaggaacagg cctgctggcc cctcccttcc agccaggtgt ctctacccac 360
agccaaacga tgatggcaaa aacagaacat tcgaatccag aaatgaccca tctgttcaca 420
agtgtatcaa tctgcctttc atgctaccac aggaggacgc acctctgagg gtggggtggg 480
tgactcccca gtccaagcat c 501
<210> 253
<211> 401
<212> DNA
<213> Homo sapiens
<400> 253
atccagaaat gacccatctg ttcacaagtg tatcaatctg cctttcatgc taccacagga 60
ggacgcacct ctgagggtgg ggtgggtgac tccccagtcc aagcatcacc cctttctgtc 120
aaccctcttc taaatcacca ttcacaaagg cccctaaatc tcctgatttc cattaagttt 180
aaggacaaaa cagaaaacat yctgacagtt tcttggcctc tggaccaagc tcaacctgaa 240
gctgcacaaa gtcttgttgc ctgaggatga ataactcaag aaactgtatt gctggactga 300
ctggcaatca agaccctgag aaaattattt taagaagatt aagggccagg agtgcttgat 360
attttggctg agttctatgt ctctcatttc ttctgagttg t 401
<210> 254
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 254
gtgttcctgt atcagtggct aataactcaa gggcagtgat tgggaatata acttccaata 60
attcaactca aacaacaaag aacattctga caggtgtttg gaaagcatac ttgctgaaca 120
cgatgatgaa caaacaacaa ctttataaac ttgtatttgt tgctgagata gccagtatct 180
aaccatgaaa aagagtgaga aaacagctct caaatcagtt aaaaccagtc tttgactgcc 240
gagttcatgt ctcttgcatg ttagatcaaa aacgaaagga ggaggagtgt caaaaaattt 300
aaaaataaaa gccattttac atgtcaggca gtggagtact gagtgatgac ggcatcctat 360
aaaattaaaa tatatgatgc ctgtgggaaa gccccgggta gggagttgag ggtacgaggc 420
tttgatatca gttcttacct gaatcaccat atgcaatctt atgcaactca tttaatctct 480
ctgggcttta ctttttcctt ycctaaaatg gaaatagtaa tctctgcttc tctttagttt 540
ataaaaatgt aaattaagtc cttattacaa aaatctgcat atatacatat atatagacag 600
agagagagaa agacacttaa agaggtgaac aatttaggag caactgaata tacaataatg 660
gaattacaaa gaagaatgaa acaacagaaa atatattttt aaaaacaatt ttcagtaaaa 720
aacaagaaaa aagatgcatt taaaaaaaat tgtaaaagca ctagaaaaaa tctaattaga 780
cttccaagga ttaaattggc cttcgtatgg caactttgaa aaagtagaaa gttggaggtt 840
aaggaaaaaa aagttacagt atacgaatgt aaaaattttt aatattttca atgagaataa 900
gcatttagga cttttttaag ttagggaaga ctctgaaatc cttgttccca tgttaaaagt 960
gcacacgcac caaaagagac agcagatgca aactgctttg c 1001
<210> 255
<211> 601
<212> DNA
<213> Homo sapiens
<400> 255
ttatttggcc agtctgactt gggtctgaga acaagacagt tacacatttt tagggtatga 60
gggaaagacc tttgtttttg ctctggctct gcacacctgc aagtgctcaa gtacacatgt 120
gtgggggcgg cagcaggaga aaggggactg ttcctctctt aaaggggcag tctctattca 180
aatgcaacca cctctttctt ctaaacccat cagtaactct gtctaacaca ttcaagctaa 240
cactcagaca caaacttgga cagtgagcca gtgaagctca agtcaggaag tgggtttctt 300
yatagctctt tcctcctgat gtcttctagg taaccggttc ttttaagaag tcaccagaga 360
tgggttaggt ttggatttgg gggaagggga taagaatttt gttataaacc aaagaaaagg 420
tttttccagc cactataaat gtacaaagaa aaatcttcct aagtgtgtag gtaatgagaa 480
gaaagaaaga tatgttcact gatcagggtt agaaaacagg actttagaag tctgaagatt 540
atagtctttt ctcagtagga ttctcaactt gctctctgga atttatttta tcctaggggt 600
t 601
<210> 256
<211> 501
<212> DNA
<213> Homo sapiens
<400> 256
atggtctgaa ggttccgctg ccttctcttc gctgcctttt tttccttcat agatgctcct 60
tccgtaaaca tcttgcacat ctaatcatgt cttggcacct gctttccggc acactcaaac 120
taacacagta ttttgaatat tttctgacat gtgaaaaccc tgaaagtcat cttatttgtt 180
gtttgctgtg taacattggg ctagacctcc tcctctaaaa agaaaaaaaa aagtctcgat 240
tccctcattt rtacaatggg cataacagaa acttcctcat gtgatatttg gtgaaggatt 300
taaaaagtca gtgtatatga aggagtctaa gcacacagta ggaacttaat acatctggga 360
ttgagctaaa taattgaaaa gacctaatta ttattaaatg cctgctacgc cccatgacac 420
tgccagcaat tactgcaatt ctataagtaa aatgcgttgt tccctggcct caaggaactt 480
agaattatac tggaaaaata a 501
<210> 257
<211> 714
<212> DNA
<213> Homo sapiens
<400> 257
tgaatatttt ctgacatgtg aaaaccctga aagtcatctt atttgttgtt tgctgtgtaa 60
cattgggcta gacctcctcc tctaaaaaga aaaaaaaaag tctcgattcc ctcatttata 120
caatgggcat aacagaaact tcctcatgtg atatttggtg aaggatttaa aaagtcagtg 180
tatatgaagg agtctaagca cacagtagga acttaataca tctgggattg agctaaataa 240
ttgaaaagac ctaattatta ttaaatgcct gctacgcccc atgacactgc cagcaattac 300
tgcaattcta taagtaaaat gcdttgttcc ctggcctcaa ggaacttaga attatactgg 360
aaaaataaaa ggtttggaga atactatgga atgtaggtga cagctagcac ttagagccta 420
gcttcctgta tacccagcac tgctccaagt gctctccata aactaattca ttagttctca 480
caacaagcct atggtataga aactattatt actgccattt gcagatgaga aaacagatac 540
agagatgtta gcttgccaaa ggttacacag ctgctcactg gcagggcctg actccatgct 600
ctcaattcta cagggatggc ccctgaatgt tgcccttggt aaaactgcat gggatgacca 660
ctctttcttg tgtttaactt ggacttctct acctgcaggc atccccaagt gact 714
<210> 258
<211> 501
<212> DNA
<213> Homo sapiens
<400> 258
ctccactgag atccccaggt ccacgccagg caccccttta ggatccactg ctaaacccag 60
caccgtgaat ggaatccctg ccagcatctc agctgctggc tgacaggaag gctctattta 120
agctgagggg gctgccagct tcctgcaact agttaatcac aacagcctct gagcaagaaa 180
gggaagacac tctgtttctg cccttctcat tcccaagctc ttttcctctt atccaatcag 240
gtactgccca rggatggtct acattgagac tgtgatggct tcagcaagcc tggaagccag 300
ccccagcttt gcctggcctg cagacctcag tgaaatgccc taacttctct gggcctgact 360
ttagccaatt cacactgtct tacacaacag catttacatg gagagacttt agattccaga 420
gcttcgctcc tgttatctcc ccaaattaaa aggctctacg ctgttcctaa tcacatgccc 480
acagcacaaa ttcacactgc a 501
<210> 259
<211> 601
<212> DNA
<213> Homo sapiens
<400> 259
tctgtggcta tgtctgacaa tctggaatga agttcaataa aggtgattta taggtcaata 60
attctggacg gaagccaagg ccagctctct tccctcccac atacccctaa cccacatgca 120
tatagtgttc attagtgaca agagggagat aaggtcctaa tcagtctagg caggcaactg 180
caataaccaa ggagtactct cattatctaa tatgaagaaa agattttcta ttcaggtgag 240
acatttggtg cttaagattc aattcagaag ctacctctgt gcagaatgca attacataca 300
yggccttgaa taagtcattt ttttgtgcct cagtttcatc atctatgaaa tgggactaga 360
ggggttgaga ggaagagaga ctactatgtg acaacccatt atattattct atacctactg 420
aaatggagaa gcaagaggaa gaagagatgc ctatgttttt caaggacttg gaaagcgttt 480
tgcttaggtc tataaaatgt atatagaaag cattgggcta cttctctagg actgtgttgt 540
aattagaagg ggttcataat gtatcttcga acaaaagaaa atggagcttt ctgatggtat 600
c 601
<210> 260
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 260
tatgtttttc aaggacttgg aaagcgtttt gcttaggtct ataaaatgta tatagaaagc 60
attgggctac ttctctagga ctgtgttgta attagaaggg gttcataatg tatcttcgaa 120
caaaagaaaa tggagctttc tgatggtatc agtttgataa ccgtaaacag ttcacagtaa 180
ggtaagaagg tacattttgg cggaagccaa cattgcattt gatgtattct taactcagct 240
aacaggcagg ctttcaagcc acgttatctg cccccgcatc ttgacctcat ttaacaagtt 300
gctatgggag cccagtgaag gttgatgcaa ttttcttatc tttggaggaa gaatgtaact 360
gtgcaggaga atgtgaaaat tcagtttcta actggcttcc gcacttacag tgcagtaaga 420
aagacatcct atcaagaagt aaaatgtatt cctttggacg tgatagggac aaagacccag 480
actcctggtg aaatggcagg dagatggatt ctcttcccag cttggagaat ctaagcatgc 540
accctttagt tcaggccaag taatagtgac atagagctat gtgtacccct actgtgtggc 600
caaacatact ctggagcaat caaattttaa gggaacagac agaaaagttg agcagaacct 660
gagaaggtga gtgtgacttt tacaagcaat aaaatgtatt gccaacaagt ctatacaatg 720
atttctgctt tccaaagtac ttttgcaaat ttcagctcat cttaacatgt ctgcataaag 780
ctagacagcc atttataggc actctagtga ctgcctcagg tggtgggtga ggctgtatgg 840
gcacatttca tccgcttccc tattccctag gacgcatctt aaatgaggtt ggcgggggca 900
ccatgagggt gtgagatcac cctcagaggg tgagtctgca gtacaggcag gaggtgttca 960
ccaggtatca attacaggga aaaaataaat actaaaatgt g 1001
<210> 261
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 261
ggagaaagaa ttaaatggta agaggcttca aaaatgtttt ttcattaaaa tgattacttc 60
agactttgag acttttaaga gataatcacc accccttctc ttctactcac taaatgtttt 120
actcccttat cccatttctg aagaaagaga gagagaaaag aaggaaagga gggaggaagg 180
gaggaaggag ggagggagag agggagggaa ggagggaagg aaagaaggaa ggaaggaagg 240
aggaaggaag gaggaaggaa ggaggaagga agggagggag ggaggaaggg agggagggag 300
gaagggaggg aggggaagga aagaaggaaa ggaggtaggg agggagagag ggagggagga 360
aggaaggaag gaaggaagga aggaagggca gaagagaggg tgggcaggca actatcaatc 420
tatccaaaca taactcagac ctagagcata gttttctctg caccacaaaa acagaagcaa 480
gcactgccaa ttagagataa ygtctacctc ccaaggccac aaagtcattt tagagctacc 540
tctgcctttc ctttctcttc ccaattaagc agcacatctc ccttccttta tcactatatt 600
caactgcagt ctagttcttt aacccctaac aggtataact gcatgagctg gcactcttgt 660
acttcctgag agtgacttaa tacacttttc ctcatcccag acgtttttaa tggaaatgga 720
tatacttcct aataatctcc tttcaaagat gggaaaggac tcccttgaaa agtactaagt 780
tcctacatgc tagccatgtt caagcaaaga ccaccagggt attgtagaaa gaataaagta 840
aggaccttta agttccattc ctggccttga ccttgttgct actccaacat gtagacataa 900
ttcctgagca ctactcatgc aatgaactgc actaggagct acatggaatg caatataaga 960
gagatactcc tgatctttga aggaggagta agttttcaag c 1001
<210> 262
<211> 501
<212> DNA
<213> Homo sapiens
<400> 262
gaaaaacacc caaaatgtaa gtttcctacc attcttggaa atgatccctt tgaagagaat 60
gatactattt gcttccaaaa atcaatggct attcacaagc agagtggctg gagagagact 120
aaagaattct tagagagact tctcccccgt gccctgcaaa agggagtctc tcgtcgtctc 180
tggtcagagg tgcagagtgc cttccaggac cccacccaca gaaacgtgca gatggagttg 240
gcctaagcag ygggagggcg cctacctgtg tagccagcta gggcagcagc aggaatgaca 300
ggcttgtcct tattgaggtc agcacggtcc cgcacatagt ccttgaaggt gcccttgggc 360
ttgtggttgg gcagggcagc cggatagtcc tctgagtcga agctgtcata ggagggaaca 420
cgctgcaggc tgttgaaaga tgactggctg ctccaggact gggtgaggcg atcacaacta 480
tcgtagctct ctatgctttc a 501
<210> 263
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 263
caggctgttg aaagatgact ggctgctcca ggactgggtg aggcgatcac aactatcgta 60
gctctctatg ctttcaaaag agtcctggcc cccgagttta cctggaggta aaggaggagg 120
taggaagagg acagggggag gagggagtgg gaaaaaaaaa aaactgtaaa aaccctctta 180
tggaggacag attgctaatc agatctgcag gaaggacgga agaagggaga ggcgagtggg 240
aacagaagct tcaggggtca tgggtttact ctgaggaaag gggctgcact aggccaccat 300
ccgagggtcc acggccactc tgctgcctgg tttgagaact ccaagtacag agattcagag 360
tcaaacgttg ctcacatctg tcggagtagc gtttgggtcc tcaagagttc taaagccaga 420
aatctagaag ctgaggatca cacatgttat gatatgattt ctggctgatg tcgtaggccc 480
aatgaataaa tgaagaaatc rgagcaatgt caggctgaat tccccactcc agctcaagcc 540
aatgagatga cttcaaaagg cccagtttgg aaaacatttt ggtcataaga aaaaagaatc 600
ccattagact aagagcagat tagcctgttt tgaccttgga actaagtgct attttttagc 660
atttttccca aatactattt taatatgaaa tacatgtact gaccctatgc cttttcaaat 720
agagtaagat ggtgtaagat gcttttccca agagattttt taaaatcaca cacactatca 780
ctcttctaaa cagaaaacca tattctttat cctctccaag taaaattatg tacttgaaat 840
ttaaacttca ttggaaaagt gtaggcaata tttaaaaggt ttattaaaga gttaaggtcc 900
acagcagtgt cagaaatcct ttactgtgtg agttgcttaa ggcattctta actgaccaca 960
agatcatgca agttcattaa tttcccaaac caggttataa a 1001
<210> 264
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 264
agcaaaaaaa aaaaaaaaat agttttggag gaaaacaaat gaatctaaga gcgaaaaagg 60
ctcgcaggaa tggtttttat atgcaacttt cagatacttt tcaagtaacc taagttaaat 120
cataggagac tagatggtca cctcaattca gcacaggcca aaaggcaaag ggatgtgaca 180
aatgtttacg gagaaatatc cgtaagtcaa ctcttaattg ttcaggggtg gttgatctat 240
aaatttcaaa tcccagaata aggctgactt atacaacttc atattagtgt gcctccagtg 300
tatttttccc tccatgacag cggagattgg ttaaaacaat aaacatcaaa catgaacaga 360
tgcccaaacc taaattaaat atataggaaa atatgttgct cccaacattg tttaaagatc 420
cggataaaat gtattcggtt gagtgtgtac tttttgtaaa atccactgct gtgggttttc 480
tctacatcct gaccccctct rgaactgctt taaacagaaa ggtggtgtca tccgtttcat 540
ctcattcctt cctccactca tccattcaga ggagggtaat ctctggaaag caaactgaag 600
agcttcatgg agttatcagc cctgcccacc cagtccacta gcaaaagggc acctcttcat 660
tcttactaaa aatgaatata tatttcttta taattcttaa aaattctttc ccatttaccc 720
accagaaaag tcatcttttt caccttttta gagatcattt aattttcttt caagaaattc 780
acactaaatg atttaagaaa acagcctaca accagaatgt caaagccttg ttttagcaga 840
acaggaaatt ctgtggcgtc tcataaaaag gtatttgttc ataccagcta ctgatcttca 900
tggtcactta ttttctcttt gagacaaaca taccaaaagc ctaagaagga gaatttatat 960
tttcatcaac accgcaccaa gtcgatagta tttatgctaa a 1001
<210> 265
<211> 1002
<212> DNA
<213> Homo sapiens
<400> 265
caggcttact gcagggtcgt tcagagcttt ctgtccgcag gtgcacttcg tctcccttcc 60
tctccttttc ctaggggagt tggcatctgg gcaggagctt gactgggttg ctcttctctc 120
ccttgacaca agcgcagtcg catttcacca aatggagtca ccttaccagt gtcctgcttc 180
ttgtctgggc ctgaacttga aacctgaggg caatgggaaa aatacaaaac aaaaaccaga 240
catctgttag aggaaatgga gaacgtaaaa tctatggcct aaagactgca atatattttt 300
gagaaatttt gaaattgatt agtttggggg ttggggattg atcctgctaa cctgggatgt 360
actcaagcct ttggctatag tgtggtcgac atacacgcag cacgaatgca ttgagaatga 420
atgctgaatg ccttctgagc ccttagagat tactcatgga ttctctttcc aagatactaa 480
atcccatttt gcagctactg aaataataac cttagtcata tttttttgat ctcatcttta 540
gacaaggcca cagtcaggac agactcagat accaacccag ttaatgagta tgcagatttc 600
ttagaaaagg ggttgagatc attgtggtct ttgcatccaa gatcctttta ggccaagcat 660
gacttgaata ttgacctctt tgttccttcc ctatctgttc attacagagg atgtgaaacc 720
atatcaagtt aatggagtca acccagccta tccagaatcc cgctatacct cggattactt 780
cattagtaag ttcatttcta cccctcttct ctcatgataa tagcaaacta ggaaaagacc 840
cctatctcag tgaatctcag gctccttcat ggtaattcta tcaaaaatar tatcttctta 900
gatgtagact cttctttgtt actttatttt attattttcc acaaagcaca aagtttcaac 960
ctatatatat gtttcattaa cctaccaagt tcctacacac ta 1002
<210> 266
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 266
actgcactcc agcctgggtg acagagcaag actctgtctc aaaaaataaa taaaataaaa 60
taaaataaaa atatactgaa agttgaaata aaatgaagaa aaggagatga gtgatactga 120
agaaatcgcc taccctgagc ttcattttac agacaaggac aataatagga cttgtcctta 180
ctatctcaca gttattttga taatccaaag agaaaatgta tttgaaagca ctttggaaac 240
agggagacat gatagagata ttaattgtaa ctacaatcag agatgggctt agatagccca 300
aaacacctag cagctccatt ttgataaatg gaggaaaaca gcctcttagt agaatatact 360
gggttacaca gtctgattga atctgctatt gtgtttagaa gtcaacagtc aaatcagatc 420
tgttaggagc ctgccgtatc gtttccctct ataaacaggt cgctcatgtc aacacctatg 480
agtgggtgtc tgtgcatgga daacatgccg gtgctttgca actgcctgcc atcctcggta 540
aaagcagcca cagaaagact cacctagttc tttcctgtat tcctttatgt cttatttttc 600
aacagaaagt gaaaagaagg aataaagata acatttttga gcacagagaa atctagtttg 660
ggtctctctt gagcactgca gaatggaata tattcttaac caaaggaagg tataatgcgg 720
ggtaaaagtg ctaatcctga gttttgctcc cctcccccag cgtctgtgcc aagggttaga 780
gctgatgacc acagggaaag gatgggcctg ggttagagag ggcaatgggc ttctaggctt 840
acagtcagct gaagggcact gctgactgct ggtaactgca atttatttta agaaaaaatt 900
caaaaaaata agcacaaaaa cacccaagtt tgccgcctgc tgctgtttct atactcagcc 960
aggactgtgg tacatgagtc acttggtcca aaaaggttgg a 1001
<210> 267
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 267
ataaaatgaa gaaaaggaga tgagtgatac tgaagaaatc gcctaccctg agcttcattt 60
tacagacaag gacaataata ggacttgtcc ttactatctc acagttattt tgataatcca 120
aagagaaaat gtatttgaaa gcactttgga aacagggaga catgatagag atattaattg 180
taactacaat cagagatggg cttagatagc ccaaaacacc tagcagctcc attttgataa 240
atggaggaaa acagcctctt agtagaatat actgggttac acagtctgat tgaatctgct 300
attgtgttta gaagtcaaca gtcaaatcag atctgttagg agcctgccgt atcgtttccc 360
tctataaaca ggtcgctcat gtcaacacct atgagtgggt gtctgtgcat ggagaacatg 420
ccggtgcttt gcaactgcct gccatcctcg gtaaaagcag ccacagaaag actcacctag 480
ttctttcctg tattccttta ygtcttattt ttcaacagaa agtgaaaaga aggaataaag 540
ataacatttt tgagcacaga gaaatctagt ttgggtctct cttgagcact gcagaatgga 600
atatattctt aaccaaagga aggtataatg cggggtaaaa gtgctaatcc tgagttttgc 660
tcccctcccc cagcgtctgt gccaagggtt agagctgatg accacaggga aaggatgggc 720
ctgggttaga gagggcaatg ggcttctagg cttacagtca gctgaagggc actgctgact 780
gctggtaact gcaatttatt ttaagaaaaa attcaaaaaa ataagcacaa aaacacccaa 840
gtttgccgcc tgctgctgtt tctatactca gccaggactg tggtacatga gtcacttggt 900
ccaaaaaggt tggaagaggc tgttagggga ggccatgtca ttataaggtt gcaacatagc 960
gtcctgatat aaccccagtt cctgctccag atgtaaaagg t 1001
<210> 268
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 268
agtggcgtga tctcagctca ctacaacctc tgcctcctgg gttcaagcga ttctcctgcc 60
tcagcctcct gagtagctag gattataggc atgtgccacc atgcccagct agtttttttt 120
atttttagga gagacagggt ttcaccatgt tggccaggct ggtctcgagc tcctgacctc 180
aagtgatcca cctgcctcgg cctcccaaag tgctgggatc ataggcatga gccactgtgc 240
cagcatgagc aggcaacatt taaggggctt tccacattgt gctaggtcta aaatgtcctg 300
catccctgac aaacaaatat gtttactctt cctgaacacc tctactagtt tatacacagt 360
ccctgcttat ctttcacatt taccgagaat attaatgtta ctacatactt tcagttacct 420
atgaaaatga aataacaata ttcattcatt caacaaatga ttatctagca cttgctttgt 480
gcaaggaatt aaagaaacaa magtgagcaa cacagaaata gtctccacag gagctagcta 540
tctgattctt gcagtagatt cagccactaa aaatctatct acacagttaa atgttcaaat 600
gcaatgtcaa taagggcttc aaaggagaag tacatgatgc aacgttaatg tgcaacagga 660
attcctggaa gtctgaagga aacaggaaag gcctccctta gaagatgaga gatgtttgac 720
ctgaattgtg aaggatgcat gagaatttag gaagaaaaga atactccaga tcagtggttc 780
tcaaagtgta gtcctcagag cagggacatc agcatcaact acaaaaagat cattttgttt 840
taagatcacc ttatccgttc tgtaaagagt gatttagggg tgagtatgaa tggatgagca 900
agacatttta gaaagttatt gcatcagtcc tggtgagaga ggatggtggc tttgactaca 960
aaagtggcaa ggcagataac ataagtgaac atgacttcaa g 1001
<210> 269
<211> 401
<212> DNA
<213> Homo sapiens
<400> 269
ggaactgaag aatgagactg actaggaggc ccccagaatc ttctcaacat gaaagctggg 60
acagtgggat gccagtgtga ggtgacagcc aaggacgaca gcagaaagcc tgaaaaagaa 120
gttccttgag tctgcctccc ataactacac aagccctggc agtgtggtct ggacaggact 180
gctgagctga caattctcca ygtaggtttc tgcttcctgt cagggggcag gcacttctgg 240
gttctcactt gttctctccc aggaaagcag ctagaattac ttttgccttt ccacctcaat 300
gccatctcca caagcccagt ccacgtgctg ttggggcccc atcagaggtg cctggctctg 360
cccctctggc tgtgagactc aagtgctaga tctctttaaa a 401
<210> 270
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 270
gctgagctga caattctcca cgtaggtttc tgcttcctgt cagggggcag gcacttctgg 60
gttctcactt gttctctccc aggaaagcag ctagaattac ttttgccttt ccacctcaat 120
gccatctcca caagcccagt ccacgtgctg ttggggcccc atcagaggtg cctggctctg 180
cccctctggc tgtgagactc aagtgctaga tctctttaaa aaaagggttc acatcccagc 240
tgggggaaac catccctgtc cacttaggac acttgcattt ggacttgatc agctccagag 300
aaggcacagc attgtctttg gagccaaagg attcagatgt aaaagtcaga actttatcct 360
ataaagtgtg gaattgtagt ttaaaaagaa aaaaaaagtc aaactccctt ctataactaa 420
gtgaacagtt ggcaaagatt gtctttttcg gttgtgtgag cattgctctt aagtgatgac 480
taatcatgct caaaaatgta yattaaatag aaaataaact caccatataa aatactaatt 540
caaaaattct cttcatgttg tttgcagatt gtagcagttc tgttcaatat actcatcaaa 600
aacaatgaca aaatcattac acgggtgaaa aatctgacat gacttagcct aagcagatat 660
cgctttactc ttaaaatact ttacttcatc acctattata atatttttac attaggtaca 720
aaatatttct aattttagaa tcagtgtctg aaagttaatc actacctcca tagacattaa 780
ctaattatat tttatggaaa aatactgaaa tctcctttgt gctaataatt acaatatctt 840
aaattcaaat aacgtatttg tttcaaaatg ctgagaatcc ggcctggaga aacactacgc 900
caacacagtg gagattctaa acacaacgca ctggaaaatg aggacataaa tatattgcaa 960
ttatattaga tttcctgccc actgattatt ccttgggacc c 1001
<210> 271
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 271
catccctgtc cacttaggac acttgcattt ggacttgatc agctccagag aaggcacagc 60
attgtctttg gagccaaagg attcagatgt aaaagtcaga actttatcct ataaagtgtg 120
gaattgtagt ttaaaaagaa aaaaaaagtc aaactccctt ctataactaa gtgaacagtt 180
ggcaaagatt gtctttttcg gttgtgtgag cattgctctt aagtgatgac taatcatgct 240
caaaaatgta tattaaatag aaaataaact caccatataa aatactaatt caaaaattct 300
cttcatgttg tttgcagatt gtagcagttc tgttcaatat actcatcaaa aacaatgaca 360
aaatcattac acgggtgaaa aatctgacat gacttagcct aagcagatat cgctttactc 420
ttaaaatact ttacttcatc acctattata atatttttac attaggtaca aaatatttct 480
aattttagaa tcagtgtctg raagttaatc actacctcca tagacattaa ctaattatat 540
tttatggaaa aatactgaaa tctcctttgt gctaataatt acaatatctt aaattcaaat 600
aacgtatttg tttcaaaatg ctgagaatcc ggcctggaga aacactacgc caacacagtg 660
gagattctaa acacaacgca ctggaaaatg aggacataaa tatattgcaa ttatattaga 720
tttcctgccc actgattatt ccttgggacc ccaaatttca gttaatattt ataggaattc 780
ccctagacct ctgaaaggac agttgtgcag aagctggtga ttaaataacc attgcaggag 840
attgcacagt atttagacag aagtgagcag gtagctttct ctgaatctac agaagaataa 900
gctagtggca ttttgaatgc agggaaacat ctgctcattt ttcattgtgg cctaaccctg 960
aaccacctca tagatgtttc aagtgaaatg taaaacaagg g 1001
<210> 272
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 272
caatcaatga tcatgtgaag actggagcgt ctgggatcct agggttagga gatgagggat 60
acagccaagg acaagaaatc caaggtgcat gtcccagttt tgcatgacca ttgaactggg 120
cccaacccca tcagattatg ataccagtca tgtgtgttgg gtatggtcac actcaatagc 180
agcatgaaag aaatactaag agtgagtaat atgccttata cctgagaaat gctttacagt 240
ttgccaagac tcttcacata cactattcca aaatatcctc taaacataaa actggagggg 300
cctggaaagg tatcacaagg tccccatttc acagatgagg aaatcaaggc cctgggagat 360
caagagcttg acctaaagtc acaaggccaa gagggaccag ctggggctag aagccagtct 420
tctaactctt aaagttcagg gtctttctct ctattccact gcaaacagaa atggatcaga 480
tatccaggaa aactaacatt kttcagagct gagaaaaaaa aaatgggact tttcctttct 540
tattttgaaa gattttagga gtgattaaaa acttaaaact attccaagaa acccagggtt 600
tcatacagct agccccgtaa gaacataatt aagagccatt tacagaatca actataatct 660
tttcttttcc tggcactcag gcaactgagg cttccttcca tatgaagcaa atgagttaag 720
tgaaaacctg gcttccttct ctgtccaacc ctgactcaac ctaatgggta actttgcata 780
taacagaagt ttaatttgtt acataaaggc ttactgaaat atatttttta aagtaaaagt 840
aaaccaagaa taaaccttct ggtccacatg gagaggataa aagaacagtt ctccaaactg 900
aaagatagga ttctaaagac aaagaaaaaa gagagagagg ggcgtgcatt gttgataact 960
tgttgatcaa aatccatagg ttctgatttc acatacgcca t 1001
<210> 273
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 273
ctaacatttt tcagagctga gaaaaaaaaa atgggacttt tcctttctta ttttgaaaga 60
ttttaggagt gattaaaaac ttaaaactat tccaagaaac ccagggtttc atacagctag 120
ccccgtaaga acataattaa gagccattta cagaatcaac tataatcttt tcttttcctg 180
gcactcaggc aactgaggct tccttccata tgaagcaaat gagttaagtg aaaacctggc 240
ttccttctct gtccaaccct gactcaacct aatgggtaac tttgcatata acagaagttt 300
aatttgttac ataaaggctt actgaaatat attttttaaa gtaaaagtaa accaagaata 360
aaccttctgg tccacatgga gaggataaaa gaacagttct ccaaactgaa agataggatt 420
ctaaagacaa agaaaaaaga gagagagggg cgtgcattgt tgataacttg ttgatcaaaa 480
tccataggtt ctgatttcac wtacgccatt agtgtagaca cactggataa gtcacttact 540
caattcactt tgaaaagagg tctgttcata ggtggtgtct atatccctca tagagtttta 600
cattttttat ttggcaattt tcaaacatac ataaaagtag agagaaactc tactcaaaat 660
ttatcaatac tacccgtttt tatttcatct tccacacaca tgcacaccca tacacacacg 720
cagaagaatt atacacctaa tcccagaaaa caagtcattt cacccacaaa tatttcattg 780
tcacaaggat attttttaga taaagggaga tcatagagtt aaagttcaat aagaggcaaa 840
taaactcaag gaaaaagaaa aaaagccttc aagttacttt ctctcatgct taaatctagg 900
tctatatttc atgcattggc ccacttgaac cacagaactt ctttcaaagc aacactgtca 960
tgatctggaa agtgccaatg ttggatcaca gagatgattt c 1001
<210> 274
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 274
tactcaattc actttgaaaa gaggtctgtt cataggtggt gtctatatcc ctcatagagt 60
tttacatttt ttatttggca attttcaaac atacataaaa gtagagagaa actctactca 120
aaatttatca atactacccg tttttatttc atcttccaca cacatgcaca cccatacaca 180
cacgcagaag aattatacac ctaatcccag aaaacaagtc atttcaccca caaatatttc 240
attgtcacaa ggatattttt tagataaagg gagatcatag agttaaagtt caataagagg 300
caaataaact caaggaaaaa gaaaaaaagc cttcaagtta ctttctctca tgcttaaatc 360
taggtctata tttcatgcat tggcccactt gaaccacaga acttctttca aagcaacact 420
gtcatgatct ggaaagtgcc aatgttggat cacagagatg atttcaaatc aagatggtaa 480
gccagttcca gggacttcca yttcctacaa gcagaaggct gcagtgatat ttcctcttaa 540
tggtcaacat cctcatgaac ttacaactgt aactaaagtg tacaaaacaa ataaaaaggc 600
tcggagttct ggccagcaca gaagggcagt gtgaaaggta atatcattgc caaactgccg 660
acaacaagtc ccagtttagg agataaggtg cctttacccc ttcagaccaa cacaaataga 720
gaaatggctg cagccacact gacggctctg cttctgaagt tgatgacccc tggagggtgg 780
tcactggtct acaagaggat tctcctgata aaaaagctaa tgatctcaga agaatgtgca 840
aaggaatctc aaagaaagac agtctctatt gccctctctc attcatataa aggcagggtt 900
gaagtagagt agaagggagt ggtaagtgat tcctgtgata ggcactagaa accgggcagg 960
caggacttcc agcttaggga ggtactataa tccacaaagc t 1001
<210> 275
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 275
ctgatttttg cgtttgtttt tcttattttc tcagtcgctt atttgtacct ggagaaattg 60
ccagattcct tcttgatgtt tctgtaagca ttgggaaata aaatcttttt ttttaagtct 120
ttatatttta taagatgctt ttcagtataa tcaagtagcc aatgatttgt tgagcaccta 180
ctatgtctta agctttggca ttgtcacaca tagtccactt aatcctcaca gcatggtggg 240
tagagcatcc tagagaatga aagcgagctt catctgaggg gctttgagac ctggtttatg 300
taccttcact tgccaggctg ctagagaaaa acacatattt aaaagccttt ccagcaggac 360
acattcattc atgtatttcc tattttaggc catttgccca atgtttaggg tgggagattt 420
gaactagtct aaggaatgag cgagaaaatt tagctacagg accaaggggg cagttctgct 480
ttctggctgg gatcctggaa yggaagagcc tctctgggtt tccctgaaca cctggaattg 540
atttgggttt tgctctgact tcgaaacatt tgctgaggtg gaggatggtg gaggaggtag 600
gaaagaaata aatccagtga ttaaaaatag cttgtgcatg tcaggtgcct gaacgaattt 660
gggaacatgc ctgcaatccc ttttgtctgg caggtctgaa ctccggcgct gccgaattac 720
aactgctttc atttgttttt cctgcttccc taccatgtaa tggtcaaggg ctcattggaa 780
ccatgtgtga gcctggtgag tcaccaaatc ctcaggactt cagtggtaat aatgtgttaa 840
aactcctttt gggggatggg gcaggaggtg gatgaaggga agagggagaa gtctgaggtc 900
acttcctaca gatgttcagt gtgctgagcc ctctctacag gcttctttct caggcctggc 960
tgcaggacct gaaaccagct tctccatgca atttggagct g 1001
<210> 276
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 276
tacacctgac tcccaccaca tgacatactt tatagttcct aaatgtccca gaacagtgtg 60
acttctttat ctgaaaaaca cagagccatg gtctctacat tactcaggag gaaagaatga 120
gttgggctct ttcgtctcca tggctttgca gagaaccaca ttgcatccta ttggttcttc 180
ccacatctta cacttctgaa tgaggaaaac tcctgccctg ccttcactaa aattctcatg 240
acaggatcat acggcttttg gtaccaacat gacataggat aaccccatcc aggaagacaa 300
tggagaatat ctgacaacta catcttgcta taatcccagc ttccactaat tctggtttac 360
ataatagcct ttgaggcctc atcctctgag atcttgcaga tgctgatgaa ttgggctaac 420
caatttattt taatttcact taactcccac ctataattat cattcctgct atttgactag 480
aactgtatct tttagaaagc rttttcttga atattctcat atgatttttc aaaacaagca 540
cttgtagtta ttatctttat catgtaggtg aggaaactga ggctcacaaa tgtttcttaa 600
gtgacttaac taagattatc aaaccagtaa agtgatataa caaggattca atcccacatc 660
ttcagacacg caagccacgt gttttctccc tgcacctatt cacagaatta aaagcaaatg 720
aggcaaaaat gatggggcat gataacattt cttttttcat tttctccaac attttcattc 780
tagaaaaagc tctttctgta gcagggaaga acctcaatcc ccgagactct ctaccgacag 840
caggctccat tgcacgtcct acccagaact ggcctggtca aacctcggct cggggcccac 900
ttggcacttg gtcggggggt aaaacaggca tcgggagagt ggtgctgaga atcaccaaga 960
aggccaggct gggcaaggtg tacgatgagg agttttctcc a 1001
<210> 277
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 277
atcttgctat aatcccagct tccactaatt ctggtttaca taatagcctt tgaggcctca 60
tcctctgaga tcttgcagat gctgatgaat tgggctaacc aatttatttt aatttcactt 120
aactcccacc tataattatc attcctgcta tttgactaga actgtatctt ttagaaagca 180
ttttcttgaa tattctcata tgatttttca aaacaagcac ttgtagttat tatctttatc 240
atgtaggtga ggaaactgag gctcacaaat gtttcttaag tgacttaact aagattatca 300
aaccagtaaa gtgatataac aaggattcaa tcccacatct tcagacacgc aagccacgtg 360
ttttctccct gcacctattc acagaattaa aagcaaatga ggcaaaaatg atggggcatg 420
ataacatttc ttttttcatt ttctccaaca ttttcattct agaaaaagct ctttctgtag 480
cagggaagaa cctcaatccc ygagactctc taccgacagc aggctccatt gcacgtccta 540
cccagaactg gcctggtcaa acctcggctc ggggcccact tggcacttgg tcggggggta 600
aaacaggcat cgggagagtg gtgctgagaa tcaccaagaa ggccaggctg ggcaaggtgt 660
acgatgagga gttttctcca tgggcaaatg aaaaatctgg gcaaacaaat ggagtagagc 720
ccgtttattt aggctggaag aggtaaagtt tttctgcact tttgaactgt tttctcaagg 780
cctgcctctc cctcccacgc aggaaacaaa cacagagaca ggcctcttcc agtgagggct 840
tcagttgttc aaagttagcc cgggaagggc agaaggaaga aaggcttaga gaaaggaagg 900
aggaacgggg gctaggaagg tggtgcagtg gccatggggg tagccgccaa gggagaaggc 960
tggagctggg atcagacaga ggaggagagc tggccaagaa g 1001
<210> 278
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 278
cacatatctt tgtcttgacc acaaatatat catggaaaga ctcagacaaa agcattactg 60
gaatcaaaat atgaggttac aatattcagt tggtctccca cttgtggagc cagttctccc 120
ctcgagtttc taagcatctg gcaagtgaaa ggtggctgat agtacaaatg gttgagctgg 180
aattcagacc cctgtacagt gaaataaaga aagacagaga aagggggtgg ggtggagaga 240
gagagagaga gagaaagaga gctgcagcca cagcattgct ttgcttctag aaacaatggg 300
cagttagaga acaatggcta cagacaaagt cttggtctat ttatatctgc cactgttagt 360
cccagacagg aggaactgga agtctgccct gtatgcacag ctccaactgg acccaagttg 420
ggaggaagat gaggtcacca agaaggctgc ctgcttagaa atgggcttct tttttcttcg 480
tatagttgct tcttagccta raggttctct taagcttgct tgccttctgc taaaatacag 540
ccactgctga gaagggagag atgagaaaag taactgctgc tctgcccagc ccaaagcaat 600
taaggcctct ctgtacagag gttgcaggaa ggtgggaacg ccaaggaaaa aataaccaat 660
cgatggaggt caactctatg gtttctgaaa caacagtctt attaggtctg ttaattatac 720
atgtttagga gcactataaa ggagcttttc cctgggaaag ttccctcctc atttctttgg 780
agacaaataa agaggccaag agctgaaatt cacagatatg tatgcattac atctcaggga 840
caatctcttc ttccctttat ttcagcccct ttttgatggt atctctattt tctggaattt 900
catcttttgc tctaacatgg ctttggagag atactcaatt ttaatccttc ccaaactgtg 960
ttacttgtat ccttaatcct cctacagcct tactaaaaag a 1001
<210> 279
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 279
atttccctgc ctctgtccct ctatcccgcc ctcactatag ctataggatg cataaagcct 60
tatccaggac caaaaagcag aaaagaggaa tttacagaat ttgctataaa actttaacaa 120
ctccttggag ggatgttctc tttccttgca accagacata gttataaaat ggatgaaaag 180
tggagagaag gaggagccaa gctctgccac tggtcagggg tcttacacta ttcctggaat 240
acagaattag aagacgcttt cgatgtcatc tagttcaaac cttttctttt actggtgggt 300
aaaatgaagc tcaaggtgac atcaacttgc cttaagtcac tggttactaa ttctagaact 360
ctggctccct ctcaggattt ttttttcctc tacatcattg ctgtttactt acaacagtgg 420
actgggaggg agaggctttc tcctatatct tcactactat caagtcctgg ttcatcattc 480
tggataaaca ctactcctcc ycaagttatt aagaatcaca gaggaatgag ccatccaaag 540
atctaataaa tatgatggga ttttacagat tcatgatgct atccactcct atttcaggtt 600
ataagtctgg aataccaatg gtcagactct aaggtggaaa agcttcctcc tagcaaagat 660
ccttgttgca taccagggat attaagcaac tttcaacagt caactccgat agcatgatac 720
catggtgtct gatggctctg aaatttgagg gtgctattcc tgtcaatcca gaaagagtga 780
agactgcagt taacttcagt gatctatgaa cctttatcta aaaagcactg aaaggcagag 840
tgcctcatat catttaaagg ttttacacca ctacccttct agtcctgctg gtattccaaa 900
tagggtcact gagccatggt gatagggttg agggaataca acaaacccca ctgacaaagc 960
cagaacttaa tatcaggggc actggccagt aagttgaatc t 1001
<210> 280
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 280
tacgagccct tctcctcaca tcccagctgg acagcattct ttttttcaga aagagctact 60
gactgctcat gagcatgggg cttcttttgg gagtgatgaa aacattctgg aattagacgt 120
tgatgatgat ggcacaactc tgtgaatgta ctggaatgca ctgacatgta cactttaaga 180
tggtaaattt tatgttatat caattatatc tcaatttaaa aaaaagtaaa tgttagagag 240
agaaagagct actggcccac tgctatgagc ccaacaatga ataccttggt gatagatccc 300
tcaggcagag tttccctcta gtgggagaag caaacaccgc ctaagtacag aagcaatagc 360
tatatgctca caacagacga tgagtgctgg gatcacggct gaagcggaag gttttgcaat 420
gcagagtgag tgaactagcg gggtccagaa gcactagggg agggggtagg aaggagtgca 480
cgtaagatgt cctgggtgta sggcgtgagg gacagaaggc gggcaaggtg tccaggatgg 540
cgcccctggc agttggtggc attactgaaa gggaagacga gaggatgaga tctcccacag 600
ccacctccgc cacctggaaa tccttgtgag atggaagccc cgcgatgctc actgggagac 660
cgaccgtggg agaggctggg cacgggccat ttccagaggc agacacctgg taactgcaat 720
ttctgggacc acttatgtga ggactaaaga ggaagggcca caggttctag gagacgaaca 780
aaatccctca agttccctac cctaaagatg ctcccagaaa aggctgccga gtgctctttt 840
aaagtgatat gtgcatcttt atacttacat acaaaagatt ctcaagggga agaagtctcc 900
atcagacagg gctctttcgc cctccagtcc ctggtggggg agacagagga aaagctgata 960
gggcggtggg gtgtgggggc ggtgaaggct cactgcacag g 1001
<210> 281
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 281
tgaggaaggt gcagtcacaa cactgtgatg ccagggatct ttttgggaaa ttcttttcca 60
aaagggatca tgaattttgg cccctggaat gccccagagc acctctgatt ggttccctgg 120
ccctgactca gatcgagccg ggctccaccc tccatgagta aataaaggca gggacggagg 180
gagggagagg gaaggagagg gagcggagtg ggcagacagg aaccagaagg ccagcgctgg 240
ttcagggaac acaccagatg agatttcagc gacgggtggt gtggcagaat tcaagacata 300
attctctgag ccttacacac cactccagtt gggattcagc cctgccttgg cagccggctc 360
agtgctgctt tataatatac tgaattagtc actggattag caagcacatt tacacacagt 420
ggcgcacagc tgtttaaaga cgcaggatcc ccttttctag gtgccagatt ctggctataa 480
atcaaccatt gcaatcagca rccagcaaac cccagaggtg catggttcct gcagacatct 540
tccttagggg aagcctgcta gaactgcgat ggccattttc tggggacagg agggacatct 600
gtggcaaaga aggaaaggtc ggtgggcttt ttctgtcttg aatcttatta tcttcagggg 660
gctgccaggt cttcactgac ctggaccttc ccggcagcag cctagctcag gaaatgacgc 720
ctgggagaac aggagttcta atcctgcctg gctgtattat caagtacaga gtttttctcc 780
taaaccttga atggctgggt cacctcccag aaaagaaaag actccagggc aaagaggaca 840
gtacttcagc aattaaaata attttaaatc ctgataacat caattccaaa aaactgcctt 900
gttgaagtgg caagggcaat gtctaaaaat aatgctttag agttggaatc ataactcaag 960
ccctaactca cgttcggtaa gaatgcgtga gaggcatttg a 1001
<210> 282
<211> 654
<212> DNA
<213> Homo sapiens
<400> 282
cttgtgcctc tgaacatccc ctccctggag aactctcaag ctggggtgga gctctcactt 60
cattcctcaa ttgtctaatc tggagagtgg gggccaaagc accaattctg tacacaagtt 120
tagtaaattt ggctagccac ctttcatgtg tctactttgg atttgaaaat gcaccatgga 180
aatcaggtga aaattttttt tttttttttt ttttttttta ctttccyact actaacacat 240
cccaatggta gatatgtata agtgaaatga gtgcgttctt cctgccccta taatgacaag 300
cctgacagag aacacatcac acagaagaat gtgccaagaa tcaagacctc ttagaagaat 360
gttagaaagt tttctctcca aatggattct gtctaagtag gaaggccttg gcaactagaa 420
aggtctaaga tcaaatttat gacttgaaaa ctctatggct ttgggcaaat tatctgaact 480
taattctgga ctcaatttct tatctacaaa atgggaatta aggcatcaac ctcaaagggt 540
tgtttaaaga atgtgattat gtatttctgt aaagcacatt gcaaagtatc tgacacatag 600
taggtactct ctgtaaatat tagcttcact tctctcactc ctccaactga actg 654
<210> 283
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 283
agacatgtgt ccatatctgg tggcttaagg taaagccaga cttgggtatc ctgattctca 60
catcaggcaa cagaaggtaa taagatgacc acctatgcca ccctgcccag ttaacagcag 120
agaaaatatt caaaccgggc aaagctaaga ccaaggaccc cttaggcctg acccaaaact 180
attggtacat ggagggcacc aagccatagt gctgaacccc aattggagga ggagacacac 240
ttcgtgacct cactaggatt tgctttacaa gataagattt tcctggcaag cattgaagtt 300
agtgcccaga ttcaaaacag caaacttaaa actattatct tcatgcttgc tataatcagg 360
tgtaccgccc aacttcccat ccctacctcc ccttccctag taatccagag gtactcaagg 420
tcactactgg ctacttaagg tttacatcca ctcccaagga aacaccagca accaaaagaa 480
tacttcccag atggaaaacc mgtcatttga ccttggaatg ctctgcctcc cataatgacc 540
aaaataaggt ccggccagag gggcttacgt tttttggtaa ggaacaacac attgttttag 600
agagataatc tgacataact ctgctaagct ctgagtgtct atgcatggta ccacagcaaa 660
caccctatgt cccaaatgga aactagcagg gtgaaaaaat tgttcatcta agatgacatt 720
aatctctgta tgcctccttg gtacagttct tttccacaac atgcagctta agattcaaca 780
attttttcat tgtgttttgt gtttcctgaa gcattcctcc agctacctga agctctcact 840
gattaaaata gacctccttt actaaaaggg gtaaactgag gcacagaaga acaaagcaat 900
gtgccttata gttcagaata ggtaaacaaa aattggacat ctattatttt caaatctctt 960
tagattaaaa gaaaaaaaaa tgtatttctc aaagtccaaa g 1001
<210> 284
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 284
agacacactt cgtgacctca ctaggatttg ctttacaaga taagattttc ctggcaagca 60
ttgaagttag tgcccagatt caaaacagca aacttaaaac tattatcttc atgcttgcta 120
taatcaggtg taccgcccaa cttcccatcc ctacctcccc ttccctagta atccagaggt 180
actcaaggtc actactggct acttaaggtt tacatccact cccaaggaaa caccagcaac 240
caaaagaata cttcccagat ggaaaacccg tcatttgacc ttggaatgct ctgcctccca 300
taatgaccaa aataaggtcc ggccagaggg gcttacgttt tttggtaagg aacaacacat 360
tgttttagag agataatctg acataactct gctaagctct gagtgtctat gcatggtacc 420
acagcaaaca ccctatgtcc caaatggaaa ctagcagggt gaaaaaattg ttcatctaag 480
atgacattaa tctctgtatg yctccttggt acagttcttt tccacaacat gcagcttaag 540
attcaacaat tttttcattg tgttttgtgt ttcctgaagc attcctccag ctacctgaag 600
ctctcactga ttaaaataga cctcctttac taaaaggggt aaactgaggc acagaagaac 660
aaagcaatgt gccttatagt tcagaatagg taaacaaaaa ttggacatct attattttca 720
aatctcttta gattaaaaga aaaaaaaatg tatttctcaa agtccaaagt caaccttctc 780
caaagggaaa ctgcatgtct gtctagtaac ctataggatc attcacactt ttttttcctt 840
gagaaggaac taacttgcca gcctaccaac aattttgcca gtgccttggc atcaggcata 900
tctgcacaac ctttccagag cctatatcat agtgatctgt tcaagctgct caaagctcag 960
taatcatact aatctgtgca tagtgaccag tgctacctgc t 1001
<210> 285
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 285
aggcatatct gcacaacctt tccagagcct atatcatagt gatctgttca agctgctcaa 60
agctcagtaa tcatactaat ctgtgcatag tgaccagtgc tacctgctca aagctcagta 120
atcagccagc tatgtgggac ttgttataga tgcataaaat atgtgggtga aatctacctc 180
caccaaaaga gaaaagaatg ccttgttgac actttgatct caagctaacg tttattaata 240
acatcattat tatatttaag tgaatgtact agatactcat cgaatcaaag aaatgtttaa 300
aatccatgtg gctgaactca aatgtcaggg gatttggaga aactgactgg agcttcatgt 360
tctaactctc cgcttatttg ccctggaacc ttgggagggt aacttggcat cggtgcactg 420
cactttcctt atttgtaaaa tattggtaac tctaaggatt accatgagct caaatgtggt 480
gaagtcacat ggcaaactgt maaatgctac cagatatagc caagtattaa gatgaactag 540
caaacaatat gcacaaacgg accttagtat ttcccccaaa ttccacaaac acccaaatat 600
ttctgagaat tctgaaaaca acagacatgg aattttcaag ttagctacag ctgggtttga 660
atctgaactc ctccactcag cagctttgca accttgggca agtcgtttaa tctcagtttc 720
ttcatctatg aaatggcaat aataatgctt cactattggg gcgaaataat gaggatactg 780
gcacaaagtt tgcgcccaat aactatcaga aaataaacag aacatgagga aaaaagaaaa 840
gatggatgga gatgagaagt gcttacacaa gcaccagtag ataaactcta cactgtcatc 900
aatgatcgtt ttccttgttt ttcccccaaa aactggcatg ctgaacttag gtccctgctt 960
tggaaagaga agggtaactg cgacagacct ttctcaaaat g 1001
<210> 286
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 286
aatacggtaa ggtcttcctt atcatctgtg attcttcatt gcattctgtg catttatttc 60
gtgtcttaat gatgtgagac aactgatgca taaggtatgg aattaactta aatttttggc 120
aaaagatatc aaataggaga aatgtgtagg tactagaagt acaaaagtcg gttacatgga 180
aactctttca ctgaaaattt cctgtgataa atttcttaaa gggtatttca aaatcagact 240
tgggcagggg cagtggctca tgcccgtaat cccaacattt taggaggcca aggtggaaag 300
attgtttgaa gccaagagtt taagaccagc ctgggcaaca tagcgagacc tcatttctac 360
aaaaaagaaa aagaaaatca gactcaacaa cacattttta ttctgaacat gaatgatact 420
aatgcatcac acaactctaa acgcatcaca caactctaat tgcacacaaa aaaagtaatt 480
aattgagaac aggtataaca sctggcacat agtgggagac cctagatact tcaaaaaacc 540
cgtatctaca aacactcacc aggcttagca gattcctgtg cctgaccgag gttattttcc 600
atttgtacct tgaaaatatg tacctgattg attttgtcat cttctctgag gtttaacgct 660
tattctgata aactgataca gaggttttaa caacagtatg agtaggagga aaagtaacca 720
aaaaaaaaaa gttacctatc tcataagctt actcaataac tctgctctac ccttaaatat 780
tcctactttc aaaggcaaaa ttcatcctga ggttcaaaac gctctttggg tcctggcctc 840
ctacttcctt ccttcatccc tttctacaag taagtttttt ttccttcatg tttatctaag 900
catctctttc attccaaact tgcagcattc ttcccacgct gctctctata tggaaaataa 960
tcctttccct gttcttacac ctccttcaaa tgcttcagaa g 1001
<210> 287
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 287
tagcttactt agatggtcta aaccctgaaa ttggcaattg agagaagata ttctagaaag 60
tacgattgac caaatttagt gtctaactcg ggtggccctc atctgtgggg agagccccag 120
ttaatgtctg tcattctgat gcaattatta atagtgcccc tttacactct caaaggtatc 180
ccagtttggg tggtaaatta tacgattttc tatctctaca ccattatgat ctgaagtcca 240
acagccttaa aatttctaat attactttgg gtctaaaagc actatctggg tcaatattcc 300
acaactctta gagacagtac taaatgctac aagaaagaac aattgagaaa agtggaaggg 360
gcagtaataa gccacatttg aagtgtcaag tgacaggctt gcacccaagc agtagacact 420
ggaaagcacc tgggaaatat gacagcgttg gccaagtgat caataaaata tttacggctt 480
gaatagcaat attttgagcg ygtctgttaa gcatggctct ctgccaatga aaccagacct 540
accacaatcc accctgcaga cctatgtctt tctgtatctg catggagatt atacattata 600
caatcagaag gaaaaggggg tgcagatagg cgaaggcttc agaaaagcag ccaagtagaa 660
atagcctgtt tatgcaattt ggaaaacatc cactgaagtt ttgaaaaaga tatcatcaac 720
ccgacagaaa aaataaagca gaaagtagct agagacacat gacaagtaaa aatgatagat 780
ttgggaatag ccttgacatt cctaaccctg agttaagaac agcttaacag ctgtgagcga 840
agggtagacc tagaatactg caaacataga ggcaaatgct atcagaggtt ccttgtgagc 900
aggaaaatgg agccaaggtt ttcattaagg agcagctaaa taaaaacacg gagatgatgt 960
tgttcatata caaattcctc tctgcggtga cagtgtgggc c 1001
<210> 288
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 288
acaagaatcc tggttctctg cctttcattc tgaggtaagc attgctggaa ctttcaaaca 60
tctttctaaa gcaacacatc tggactgcca ggcctgggga caacccacag gatggaccct 120
ttccccaagc cgtatgaagc actgagctaa caatgaggcc acctgattca gctcaggggg 180
ctcttgcaga gatagcaggg agccactgta cctcctgaac ccccaaagca ccgaccagca 240
ttgccttctc acctgcctgt gttctaattt ccagagtttt tgagaataac tcaaaatttt 300
aggtataaaa tgcctacaac atctcatcag tttctaaatt tctagagtgt ggccttaggc 360
caagtatgca tctctcagaa actcattttc ctcatctgaa aaatggagaa aataatactt 420
ccaccacacc tcagagtaag tgtgaagcat aaaagtgctc ttttatctgg ctgtgcccag 480
cacacaatgc aggctcgatg ygtgcttcag aaatatccca acaacttttg aatgacaaga 540
acctaccacc ttcaatgcaa gctcatggaa ttccaccaca gccatggatt attcattaca 600
caaaccagag agacatctgt aattacactg tcactgtaac cattgcagag ttatctgctg 660
tattctgaaa cagggagact ctcctgaaaa atcctgacct acactaacca gctctcagtt 720
tgcagagatt tgatggagcc cagagagacc tgggctccgg gaggttgacc acgagctggt 780
ttgtctcctg gagggaggcg atgctcctac agggtggtct ggcctcttta agagaaaaaa 840
aaagttacac agacaaaaaa acagcaacac aaaccaacca aaaatgccag gaatgcaagc 900
tctgccaacc aaataaataa ataaaatagg agatgcttta taataactgg acatgatgca 960
tttctcagcc ctgcataatt gaaaacttga cttttccatc a 1001
<210> 289
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 289
tggctttggc acctggcccc ttcacagcag gctccaccag gagagaacca ggagtgaacc 60
caatggctat atttgttttt aagctattta agatccttgc aatcacactg ttgcaatcaa 120
atagcatatc ccaccttact cttacacttg caaggaaaag tcaattctac tgttatttca 180
gagtatatgt taatttagca cttaacgctg tcaaactcct gtgaagtctc aaaatagaat 240
aaaagtgcat aaaggttctt ggtcaggtcc tagccaggaa aacaaataat ccaggtcttg 300
cggctcctgt ttggacaccc cactttctta ctgcctctct ttggcactca tgaatttggg 360
agggggtggg gagaaaattc tggtttaatc atttaagcca gataagatcc cacactagct 420
gtctccacac ataagaaact aagcaaccca aagaaatcat tctgacaaat atttaagtca 480
cagctgtgga taaaaagcta ygctgtgaga agttaaactt taaacacatg tcctatatgg 540
tctgatgggc aaggcaaatc cgcacttagc caatgtcttg tccttccact aacaaaagca 600
gacagccctg gccagaaaca ccgtttctcc catccttgct ttgcacctgc aagttaagtc 660
tcagctgagg tttctttgct gagcttttgg aaggtatctt gcaacattac tcaaagcaat 720
atacattgcg aagttagaaa caggaattga ttgtacttca gccactggct cactacatat 780
ttttatgtca attatttacc tttcctgtga ctctattttc ctctctgagg tatgggcata 840
atgttcgcat ataagcaact aaaggtccag aaaaaaaaaa gttgattata gtctatatat 900
tttttcaagt ttttgtcttt attttttcca agataataaa taatggtgct agaaatcaaa 960
cctctttaca atgaatggca gaagactgcc caatttcttt g 1001
<210> 290
<211> 401
<212> DNA
<213> Homo sapiens
<400> 290
tctttggcac tcatgaattt gggagggggt ggggagaaaa ttctggttta atcatttaag 60
ccagataaga tcccacacta gctgtctcca cacataagaa actaagcaac ccaaagaaat 120
cattctgaca aatatttaag tcacagctgt ggataaaaag ctacgctgtg agaagttaaa 180
ctttaaacac atgtcctata yggtctgatg ggcaaggcaa atccgcactt agccaatgtc 240
ttgtccttcc actaacaaaa gcagacagcc ctggccagaa acaccgtttc tcccatcctt 300
gctttgcacc tgcaagttaa gtctcagctg aggtttcttt gctgagcttt tggaaggtat 360
cttgcaacat tactcaaagc aatatacatt gcgaagttag a 401
<210> 291
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 291
ctgagctttt ggaaggtatc ttgcaacatt actcaaagca atatacattg cgaagttaga 60
aacaggaatt gattgtactt cagccactgg ctcactacat atttttatgt caattattta 120
cctttcctgt gactctattt tcctctctga ggtatgggca taatgttcgc atataagcaa 180
ctaaaggtcc agaaaaaaaa aagttgatta tagtctatat attttttcaa gtttttgtct 240
ttattttttc caagataata aataatggtg ctagaaatca aacctcttta caatgaatgg 300
cagaagactg cccaatttct ttggccagtt gaaattttgt tgtatcgaag ttcacataca 360
aaagatgacc aatggcttgg aaatcttttt tgaaaaagaa agccattgca aatatgctta 420
ttataatgga cgctgactgt agcgttaggc cttattgttc ccattttaca gaatagaaag 480
ctaaagaaag ttacttgccc wgagcttatt tttaatcagt aactgaaatg acggcaccat 540
atacattgtc tctaatattt aatattaaat taccaaaaaa attgcctcag ctgttcactg 600
tgatctgaaa catgtgttgc cagggctctt tttcattccc aggatgaaag atcccttgta 660
ggtatgtgga ctgacatatc gacacgatat ttcccagatg accaaatctg tctcttcccc 720
cataaacacc cataacaaca catataaaca agctgttctt aaggaaagga cctattagtt 780
gagtttatat ctttgatgtg aactatcttt tcacttctat atatggtttc aatcaactga 840
caaacagaac tcattctagc ttcctcgaac ccccaaacac aaccatcata gaaacagcat 900
ttctgaattg taggcctaag tgccttaaat gtctccatgg ttccagctgc gctctcagca 960
ttgctcccac caccatcatc cttgcgagga gacaaaatct c 1001
<210> 292
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 292
tcctctgagg cagcgtccat ctccccttaa cattaaggaa taaggccaga gggttctcgc 60
tcatttggga aaataaaaaa agcaggaatg gggcgctgga aattctataa gcttttcccc 120
accactcaca aaaacacagc tgtgaaaata aataccaccc cccaaaccaa gggtctaggg 180
ccaccaacag tcctcctcct cctcctcctc ctccttctcc tcctcgtcct ccagatccag 240
ctgccaacag catcccccgc tcctgaagaa atgcaccgcc cagaagggaa cggcgaaagg 300
gggaagaagt ccaggggacc cccggcctct ggccgagagc ttgggtgggg gcctcggccg 360
tcgccactca cccggggagg ggaaaagctc cagatcgact ttttccgtct tgatgatggt 420
gagagtcggc ttgagatcga cggccgcctt catggtgcca ggagtggggg acgtacggga 480
tggtagcaag tttgcagtta btgttgtttt tctttttaat gaggattagt aacaggggga 540
aggggacggg ggaaatccga ctttcttccc aaaaatctca aattcccgct gcctttcttt 600
cccccgcgcc cggacggtgc gcgcccggca ctccagggga agttggcact ttgcggcgaa 660
gtgagcgcgc tcgggtccca gcctcgcccg cgccgcgccc gctcctcctg cccggccctc 720
gcccgctccc tcctctccgc cggcggctgc ctcgttcgct ctcgatctcc cggccgctct 780
ccctccctct cgccctcccg cgctctcccc tcctctttag ggcgtttctc gcggcgccgc 840
gtctcggccg ctgggtccgc gcgccctggg ccgggcgatg tccgcttggg ggagcgaggg 900
gcggggcgtc ggggcagggc ggggagccgg gggcggggcc gagcaccgcg gccaatctcc 960
gcccgcggcc caaagcgaaa ggaagggctg gcgagcgcgg g 1001
<210> 293
<211> 401
<212> DNA
<213> Homo sapiens
<400> 293
agcatttgac tgtaactgta acctctgcct ctggtaagtt ttgacacaca ggcttacctt 60
catctaatcc cagttttgtg cccttgaagc cttagtaatt tgcagatttc ccacagcaaa 120
tcggggagga agccaggaac agaaaaatct gtggctcctg gtctaaactc cagattaaat 180
ccctccttag tgaccagagg raaatatttg tatgtgatag tcctaatttt tgaaagaaca 240
aagactgttg caatccagct gtgtttccac aaggtatgag aaaacaatgc tggcctccag 300
atgacaagaa cagacccttc tggtcctggg aaaagcctag agaaacagct gatgaatgaa 360
ttgtacattt acacgtccaa atgaaccaca aaaaaaaaaa g 401
<210> 294
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 294
taacggctga tccagaacca gtttatgact cacagatgtt gatttactgg tataaatgta 60
agatttagaa aaaaaaaaaa aaaaaaaaaa gccctcaatt aacaacaacc tgtctgagct 120
gcatttgtgg tctcattttt ctctgagaaa aggcaacagt ctctgtcata cacagaaaca 180
agctttgaaa gcttacttct aaggcaagtg gtttctatgt gagaagttta gtcattaaaa 240
gtcacactag ggaagaaaaa tgcctggcac ttcaatatct acattatcaa gcagcaataa 300
aatggaaaat tagagatagg aaggaaaatt aaaataactc tcttaattaa acttggatgc 360
caaaaagcct tagggtcagt taagggaccc aagccagggg actcagatgg tactgttgct 420
gactgcaggc tggctctgtg acctcaccaa agccacttaa cctttttgtg tcacaacctc 480
atctctgttt cagggaataa ratcagccct agctctccct agaatggaac acagactcat 540
tggctattgt ttagaaggca caataaacaa tgagggtagg aggagctgca gtcaggaggg 600
aagaagggag ggtggggtgg ggttggggga gaggggagga cttgggagcc tgtttgccct 660
ggaaagctca atataagaaa acaaagagga tagtagtgtg ggctttggaa taagactcag 720
gttcaaattc ttactctacc aactagccag ctgaattgcc acaggtaagt catttaaaca 780
atcccgaacc tcagttcctc catgtttcaa ctagggataa tagcagcaca caccttttaa 840
ggctatttga atgattaaat gagataatgt atgcaaagaa tttagcacag tgtctaggtg 900
agaattagta tttgattatt gttattaaga tctagtatac ggtagaatat gtgggaaatc 960
acattaaatg tctgtctaca gccatctctt tgcagaatag c 1001
<210> 295
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 295
cagttcctcc atgtttcaac tagggataat agcagcacac accttttaag gctatttgaa 60
tgattaaatg agataatgta tgcaaagaat ttagcacagt gtctaggtga gaattagtat 120
ttgattattg ttattaagat ctagtatacg gtagaatatg tgggaaatca cattaaatgt 180
ctgtctacag ccatctcttt gcagaatagc ttggatgctc aattttcctg aacgatctcc 240
agcgagagat agaacaacta tcaccacatt tcatttaaaa atctcttcaa gacccttcct 300
cagttcttaa actggcaacc tgcccagcat cagcctcact tgagaaattc gagaactacc 360
tgattggaga agagaactag atttatattt gttttgagtc acagaaaagt gacagtttaa 420
attctgaaag aagatcacat ttgtagtgcc tctttggaga caaaacctta ggtcttggat 480
ttgtcacatg ttagagctca rtgggagttt atcagtgctc tccaagtcca gcactcctat 540
ttaccagagg tgaaaaatga gtgtgagtga ggaaattatt atttccaggg ccacacaatc 600
taaaaaagtc agtgtcagta ctagaaccag atgccctgat agcagttctc tccctggcat 660
ctccttgcat ttactttgca tttcactttg gcaggagaag taccagacac ccttgagaca 720
caagacagga tacaatggac atgggagtag atagatgagc agactcaatt tctagaaatc 780
caacttctct acactggatg tattgtcttt gggcaaatac attgcaggat aaccacacta 840
tggttccctg tgggagacag cttggcatgg gctgtcagga gagaaagggc ctgggttggc 900
tctattgctg tctgcagttt ctttagacta taattatgaa ccattcaact gcatctgcag 960
ccccaacaat gtggggtgga ttggcctaat ccacagacca a 1001
<210> 296
<211> 601
<212> DNA
<213> Homo sapiens
<400> 296
tgtgaaacac tttcaagagt ccagggctgg cagtgagagg taatgacagg taacgtgcag 60
aatgaagaaa gcagaaagca tatagaagtt gcttcttaat ggaaacgtgt ttcatcagaa 120
tgatcagaaa catgtgttct ccccagattg ggaaaccatc ttgaaagact tcatcacaaa 180
aaggccttgg gtgggaagta ccacaaggga cccatccagg aggggtggga ggaggtgcag 240
ctgggtggga agctggcaat ggactgtgag aggaaaaaac aaagggcagt cagcgctctc 300
rtggcagatt cccaagagag aaccctttcc aggaatttaa aattctgaat aattgttgag 360
aatttctaaa aatcaagaag attataaact tttctttcag gggattccac agcattgaga 420
gagaccagat ggctggcaac aaaattccag atccaggaaa ggtccagcat ctacatatcc 480
atccactttt agtgagctaa tgctttctcc tacagagtgt atttgtctaa ttgaattgaa 540
ttgaattgaa ctgaggtgtg gaggtaaaaa ggctattgca aataagtgtt cctgtttcca 600
a 601
<210> 297
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 297
taattgaatt gaattgaatt gaactgaggt gtggaggtaa aaaggctatt gcaaataagt 60
gttcctgttt ccaaatagtc catacaaaaa cctgcagttt cttgccaagc agaaactacc 120
aggctttggt ttcctcacta tagaataaat ttaaactcta aaataaccag ggaggcaaca 180
tagtagagtg ggttaagagc acaagcttgg cagtaaatag acgagagttt gaattttagc 240
ttggctgctc tccagatgtc agtctttgac ctcagaaagc ctcagtttct tcatctacag 300
aatggagatg cggaaagtgc ctagttcaca gagttgaact gagatgagat gagatgaatg 360
ggtgccaagt gctttgcact gtgcatgatg cagaatgaag actcagtaac ccttcactgc 420
tattattgat tttaaaaatc agaattgtga cttcggattt agtgagcata aaattttcat 480
gaatgttaat ccaaactgta rtatatagta ttcttatgaa gaaatgagga cacagtgtcc 540
tatcttcatg tgcgctgtta aaatcatgac atagtgacaa agataagttt tggtctaggt 600
atgcaaatca tgcaaatcct tgacaccatc cctcttggat gaaaggggat taattcccac 660
tatatagatg tgagatacaa ttatgaaagt tctaatcata tactcacagc tacattacaa 720
attagcagca aagagaatat gtaccctctt gaatttcttc cagtattggg ttctccactc 780
tctggattgc acgtttgata gccaatgatt tttgcaacct aaacaaaata agaccttctt 840
aagcaactgg cctcagcatt tgactttcaa tctgggaaga atcccacatg ctattcaata 900
tgcccccata gcactctgcc taggtacttc ccaaactagc acccattagg cagcacctta 960
ctgcactcac ttcacagaag tctttttcta tgttattgca t 1001
<210> 298
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 298
tgatggggac atactccaaa atgtacatgg ctgagtcctc ttgctctcct tttttttttt 60
ccccagtgac tttggggagg tttgggcagt gatcctgcat acacaatact gttcttgttc 120
ttcttttctc ttacagagca gccttgaata gctctgtcta aaattattag caggggcagc 180
cctaggctcc aagagatcac agccctcatg ctgggcctga acaaagaccc tgctttttcc 240
caacaattag ccctgcaaaa aaggacatct atctccctct attaaaacca ccacgtgcct 300
tcaagtcagc ccattgtaaa gctaattaaa taacacgcct ctctccccat gcaggtctcc 360
tgattagctt tcctctgtca gaaacctctg caaagagcct agtgatagac aagccaatgt 420
tccacttctc cttagccccg ctcccatcgc caattagccg tcgcctttga aaagccatcc 480
ttatcaatgt tggtgagttt rttcacgctc catatccatc caaagcccag acgctagtca 540
cctccacctt aaaggaatgg ataaggttca tactgctttt aaaataaatt atttggaaag 600
gcaaaagttt tcatcacagt gtaaaatctt tggccagcat tccccacatc gcaatacaca 660
agggctgccg ccgccattgc aggagagtgt cagagaagga cttttctgaa agtcagagag 720
cctgggcaag atgcagccaa ggtggccatt tctaccagat ttctaaaaac aggatgcaga 780
agaccaccct ttaggttaaa ctcccttaga tactcctcac cgccaaacag ataaaatcca 840
agcacagtcc aaaaggccaa aattggtcct ctttaccttt tgaccacacc tcaccttctc 900
ccccacatag ggaccctgct ctctgacaat cctggacttg tggcaatccc ttgaacacac 960
tctagttctt cactctttta tgcattttta caggcttttt t 1001
<210> 299
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 299
ggcagtaagt tctttattac tctcccttac cacagtgtgc ctccattctc agatgtttcc 60
ttaaagaaga gtaatctaag acctctaaat acataaaaaa taggataata agtaaagaca 120
aagagaccct catttttata tagatttgtc tcctccagat gcagcttggc atgtatacat 180
gtatacaaag cagccattga gaattaagca tgtgaaaatc acacctgtta atttgtcaag 240
gacagaccaa gtaaactata aggcagaaat aaaactgttt caacaaagat aaatggaaaa 300
catggttgaa aaagaagaat gatttggaat gaatgtcata gtattaatca aataaaaata 360
taagatgcat atagtcaata taatttattc aaatagtaag aagagaagaa atatgtatca 420
taaatgaaca ttatcatgag atattgggta caagaattca atacattggg taaacagact 480
gtagagatct taagagctta rgatttcaga gaatagcata cattctgtgg tctagaaaaa 540
gctgttttct gatccaattg agactgtgag caatgttaag aggcataaca gccaaatcaa 600
gacacacaag aagcctctca ttaggaggag aaagagcttg gaattggttg aagggagcag 660
ccgtgttgac agttcatgtc aatacattcc agttagcagg ttatttaagc aatgacttca 720
ggctaagctg gccttgtaat tctgcaaatc agatcccata gaagagcaat tagcagacat 780
tcatttcata ctctcttcat aaagtttggg tcattttaaa ttttttatgt gtcaaacttc 840
agaagtaaat atgaatacac atcacctctt tcctttgatt aaaacaatag ggatgcttta 900
ccttatttag catgaaagat cacaaaataa ttccaacatc acctcacagc acctctgaga 960
aatgcctaag aggtgggaaa ggatcccagc ctcactgtat g 1001
<210> 300
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 300
atagtattaa tcaaataaaa atataagatg catatagtca atataattta ttcaaatagt 60
aagaagagaa gaaatatgta tcataaatga acattatcat gagatattgg gtacaagaat 120
tcaatacatt gggtaaacag actgtagaga tcttaagagc ttaagatttc agagaatagc 180
atacattctg tggtctagaa aaagctgttt tctgatccaa ttgagactgt gagcaatgtt 240
aagaggcata acagccaaat caagacacac aagaagcctc tcattaggag gagaaagagc 300
ttggaattgg ttgaagggag cagccgtgtt gacagttcat gtcaatacat tccagttagc 360
aggttattta agcaatgact tcaggctaag ctggccttgt aattctgcaa atcagatccc 420
atagaagagc aattagcaga cattcatttc atactctctt cataaagttt gggtcatttt 480
aaatttttta tgtgtcaaac ytcagaagta aatatgaata cacatcacct ctttcctttg 540
attaaaacaa tagggatgct ttaccttatt tagcatgaaa gatcacaaaa taattccaac 600
atcacctcac agcacctctg agaaatgcct aagaggtggg aaaggatccc agcctcactg 660
tatgcagtat ctgtccaggg tacagagact ctctccaatg ttttgcacaa ctttgatcca 720
agtcagctgt gcaaaatact gaagatgcat attagctcaa ctctttcaaa tcattcatgt 780
gtccaaaatc actttcacct accaaagtcc ttaaaatgtg attttctcct gccaagtctt 840
tagtcgtcat ttgttggttt ttttaattag accttttatc actatgtacc ataatttacc 900
tgagacatta ttttcccact aacacagagt gtgtaggggg agagggaggg aaagcatggc 960
atggtgaata aagagactat taatccacta attcctactt g 1001
<210> 301
<211> 1718
<212> DNA
<213> Homo sapiens
<400> 301
gaggaaccac ttaatacaaa taattatttt gccatagatt aaggaggtag ttcgtaggtg 60
acatatgtat ttaaaaatct ctatccacga cagtggacag acaatggaga aagaatactc 120
ttttaacaaa taatagggga gaaccagata cacatacgaa aaagaaagaa actagacctt 180
tgtgcataaa agttaactct aagtggatca gagacataaa tgtaagagct aaagctataa 240
agctcatata agaaaaaaca ggattaaatc ttcataacct tgtgttgggc aataatttct 300
taggtacaat gctaaaagca ctagaaaaac aaagaaaava tagataaatt gggctatatc 360
aaatctaaaa cctatggtgc tgcaaattct aaacatccag aaagtaaaaa gacaactcac 420
tttatgggag aaatatttgt aaattatatg cccgataagg gcttgtattc agaatatgta 480
aagaactctt acaactcaac aataaaaaga caacccaatt taaaaacggg ccaaggattt 540
taatagacat ttctccaaag aaggtataag aatgactggt aaacacgtga gaaaagctca 600
atatcattaa ttattaaaga aatgcaaatc aaaacgacaa tgaaatacta ctgctcattc 660
accatgagga taaattggaa ccctcttaca ttgctagtag gaatgtaaaa tgaagcagcc 720
actttcaaaa acagttgggc agttccacaa atagagttac catacgaccc agaaattcta 780
cccctggaga aatgaaaaca tattcacaca aaaaacttgt acattaatgt taatagcagc 840
cttatttata ataaccacaa agtgaaaagc acctaaatgg ccatcaaatt atggataaat 900
aaaatgtgcc atggccatat aatggaatat tattttgatg ataaaaggat atactgatgc 960
ctgctacaac atgggtgaaa cttgaaaaca ttatgcttag tggccagtca caaaggtcac 1020
atattatata actctactta tgagaattcc agaataggca aatttataaa gatagaaatt 1080
agaccagtag ctgttgaggt gtggagacag gaagaatgag aaagaatgaa gatcgactgc 1140
taatggatat aagatttctg ttaagaagaa taaaaatgtt gctgggcgca gtggatcatg 1200
cctgtaatcc cagcactttg ggaggccaag gcgggcggat cacctgaggt caggagttgg 1260
agaccagtct gaccaacatg gtgaaacctt gtctctatta aaaacacaaa acattagcca 1320
ggtgtggtgg caggcgcctg ttatcccagc tactcaggag tctgagactg gagaatcact 1380
tcaacccagg aggcggacgg aggatgcagt gagcggagat tgtgccattg tactactcca 1440
gcctgggcaa caagagagaa attccatctc aaaaaaaaaa aaaaaaaaga agaagaagaa 1500
aaatgttcta aaattaaatt gcaatgatag ctgcacaata ctgtaaatac actaaacaga 1560
actgtacact ttaaataggt gaattgtata gtatgtgaat tatatctcaa taaagctcac 1620
ctcaataaac cgtttaaaaa aaaaagttgg ttttctggag gtgaaggcaa gacaaaaaaa 1680
gagggagaat ttcctatcat ccaggaaagc ctgcccag 1718
<210> 302
<211> 1719
<212> DNA
<213> Homo sapiens
<400> 302
gaggaaccac ttaatacaaa taattatttt gccatagatt aaggaggtag ttcgtaggtg 60
acatatgtat ttaaaaatct ctatccacga cagtggacag acaatggaga aagaatactc 120
ttttaacaaa taatagggga gaaccagata cacatacgaa aaagaaagaa actagacctt 180
tgtgcataaa agttaactct aagtggatca gagacataaa tgtaagagct aaagctataa 240
agctcatata agaaaaaaca ggattaaatc ttcataacct tgtgttgggc aataatttct 300
taggtacaat gctaaaagca ctagaaaaac aaagaaaaaa tagataaatt gggctatatc 360
aaatctaaaa cctatggtgc tgcaaattct aaacatccag aaagtaaaaa gacaactcac 420
tttatgggag aaatatttgt aaattatatg cccgataagg gcttgtattc agaatatgta 480
aagaactctt acaactcaac aataaaaaga caacccaatt taaaaacggg ccaaggattt 540
taatagacat ttctccaaag aaggtataag aatgactggt aaacacgtga gaaaagctca 600
atatcattaa ttattaaaga aatgcaaatc aaaacgacaa tgaaatacta ctgctcattc 660
accatgagga taaattggaa ccctcttaca ttgctagtag gaatgtaaaa tgaagcagcc 720
actttcaaaa acagttgggc agttccacaa atagagttac catacgaccc agaaattcta 780
cccctggaga aatgaaaaca tattcacaca aaaaacttgt acattaatgt taatagcagc 840
cttatttata ataaccacaa agtgaaaagc acctaaatgg ccatcaaatt atggataaat 900
aaaatgtgcc atggccatat aatggaatat tattttgatg ataaaaggat atactgatgc 960
ctgctacaac atgggtgaaa cttgaaaaca ttatgcttag tggccagtca caaaggtcac 1020
atattatata actctactta tgagaattcc agaataggca aatttataaa gatagaaatt 1080
agaccagtag ctgttgaggt gtggagacag gaagaatgag aaagaatgaa gatcgactgc 1140
taatggatat aagatttctg ttaagaagaa taaaaatgtt gctgggcgca gtggatcatg 1200
cctgtaatcc cagcactttg ggaggccaag gcgggcggat cacctgaggt caggagttgg 1260
agaccagtct gaccaacatg gtgaaacctt gtctctatta aaaacacaaa acattagcca 1320
ggtgtggtgg caggcgcctg ttatcccagc tactcaggag tctgagactg gagaatcact 1380
tcaacccagg aggcggacgg aggatgcagt gagcggagat tgtgccattg tactactcca 1440
gcctgggcaa caagagagaa attccatctc aaaaaaaaaa aaaaaaaaga agaagaagaa 1500
aaatgttcta aaattaaayt gcaatgatag ctgcacaata ctgtaaatac actaaacaga 1560
actgtacact ttaaataggt gaattgtata gtatgtgaat tatatctcaa taaagctcac 1620
ctcaataaac cgtttaaaaa aaaaagttgg ttttctggag gtgaaggcaa gacaaaaaaa 1680
gagggagaat ttcctatcat ccaggaaagc ctgcccagt 1719
<210> 303
<211> 1799
<212> DNA
<213> Homo sapiens
<400> 303
gaggaaccac ttaatacaaa taattatttt gccatagatt aaggaggtag ttcgtaggtg 60
acatatgtat ttaaaaatct ctatccacga cagtggacag acaatggaga aagaatactc 120
ttttaacaaa taatagggga gaaccagata cacatacgaa aaagaaagaa actagacctt 180
tgtgcataaa agttaactct aagtggatca gagacataaa tgtaagagct aaagctataa 240
agctcatata agaaaaaaca ggattaaatc ttcataacct tgtgttgggc aataatttct 300
taggtacaat gctaaaagca ctagaaaaac aaagaaaaaa tagataaatt gggctatatc 360
aaatctaaaa cctatggtgc tgcaaattct aaacatccag aaagtaaaaa gacaactcac 420
tttatgggag aaatatttgt aaattatatg cccgataagg gcttgtattc agaatatgta 480
aagaactctt acaactcaac aataaaaaga caacccaatt taaaaacggg ccaaggattt 540
taatagacat ttctccaaag aaggtataag aatgactggt aaacacgtga gaaaagctca 600
atatcattaa ttattaaaga aatgcaaatc aaaacgacaa tgaaatacta ctgctcattc 660
accatgagga taaattggaa ccctcttaca ttgctagtag gaatgtaaaa tgaagcagcc 720
actttcaaaa acagttgggc agttccacaa atagagttac catacgaccc agaaattcta 780
cccctggaga aatgaaaaca tattcacaca aaaaacttgt acattaatgt taatagcagc 840
cttatttata ataaccacaa agtgaaaagc acctaaatgg ccatcaaatt atggataaat 900
aaaatgtgcc atggccatat aatggaatat tattttgatg ataaaaggat atactgatgc 960
ctgctacaac atgggtgaaa cttgaaaaca ttatgcttag tggccagtca caaaggtcac 1020
atattatata actctactta tgagaattcc agaataggca aatttataaa gatagaaatt 1080
agaccagtag ctgttgaggt gtggagacag gaagaatgag aaagaatgaa gatcgactgc 1140
taatggatat aagatttctg ttaagaagaa taaaaatgtt gctgggcgca gtggatcatg 1200
cctgtaatcc cagcactttg ggaggccaag gcgggcggat cacctgaggt caggagttgg 1260
agaccagtct gaccaacatg gtgaaacctt gtctctatta aaaacacaaa acattagcca 1320
ggtgtggtgg caggcgcctg ttatcccagc tactcaggag tctgagactg gagaatcact 1380
tcaacccagg aggcggacgg aggatgcagt gagcggagat tgtgccattg tactactcca 1440
gcctgggcaa caagagagaa attccatctc aaaaaaaaaa aaaaaaaaga agaagaagaa 1500
aaatgttcta aaattaaatt gcaatgatag ctgcacaata ctgtaaatac actaaacaga 1560
actgtacact ttaaataggt gaattgtata gtatgtgart tatatctcaa taaagctcac 1620
ctcaataaac cgtttaaaaa aaaaagttgg ttttctggag gtgaaggcaa gacaaaaaaa 1680
gagggagaat ttcctatcat ccaggaaagc ctgcccagtg gggtctatga acatcatctt 1740
aagaccatat gcttcaccaa agttcagtgg aaaaatgtct aacatttcca tgaccttct 1799
<210> 304
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 304
taaatatttg tatcctggtt gtccaaactt gtcctagcta gtggagggat ggttggtgtc 60
ttggtcctca gttagatcat gggtaattcc aagttactga ctggtttagg gtgtcagtga 120
cattagagca tctttacttt gtcccctatt aatcaacaca tatttattaa gcccttgttc 180
ttcatgaggc gttggggcta tgaagtgtgg ttcagtctca tcctcaagga acatcacgca 240
acctggctgc cgtgctgaga cggacacagc caagctgcag agctggtgag caccagggga 300
ctgggaatga tgagagggat ggtcctgttg agactagaat tatggagaga ccctcctgag 360
gcctcccagt cacgtgaaac tgagggtgag ggggtttgcc ttgaggagca ctcattcatc 420
caaacttagt tggcagaatg aggacagagc tcgatttgga aaggggttgt tttactggtg 480
tttggaagag tggccactcc rgctctgctt tatgtatcct tgagcgttgt tattctttct 540
tctctctcct gtgttgattt tcacctccct caccctggtc tggcctctcc gtggccttcc 600
tgccgctttc agagatgagc ttagactcca cacggggctc ccaatctgaa tgaaatatcc 660
cattcctggg accgctgctc cctcacttca ttagtgctcc ttgctgttta taaagccagg 720
agataatatt tttaaattcc atttggagtt tcccgggcag cctctctcta agccacttag 780
gaagtttaga aaagaaggtc atggaaatgt tagacatttt tccactgaac tttggtgaag 840
catatggtct taagatgatg ttcatagacc ccactgggca ggctttcctg gatgatagga 900
aattctccct ctttttttgt cttgccttca cctccagaaa accaactttt ttttttaaac 960
ggtttattga ggtgagcttt attgagatat aattcacata c 1001
<210> 305
<211> 401
<212> DNA
<213> Homo sapiens
<400> 305
aacatcttta cctttgagaa acttgacaaa gagcagcatg aaaaatcatc tccacttggg 60
agtttatgta cttcagttta aggaaaagga aggccatgtc tctttgctat gaagaagaga 120
cattctgatc ttcaggctat gagcaaatgg agaaggcctc agatgttaat aagatgtaac 180
ttgtagcaag cagagaccat ygagagctgc aagtgttaaa gcaaggcagc tttaatctca 240
gttgcattgg gagatataag acttaagcct tgtggcatta ataggattca agaattatac 300
aaatataaat acagccattt tgaccttttg cttatacaaa caaaacctat tttgtttaga 360
attttaaagg atcacttttc tcatgtcctc aaatttttag t 401
<210> 306
<211> 401
<212> DNA
<213> Homo sapiens
<400> 306
ggcagcactg ccaccagcaa gtggaaggag agaagggaga gagagacaga ggaaaaagaa 60
ttgggatcca ggtgggcatg gacagagagg ccaggaacaa tggaaacaga tgatcatcga 120
aagaaagcat gttctctaag aaggccgagc aattcacaca cctctgttta tccagctcag 180
actctgtgac tgcaaaactt ytaggctctc tgacaacagc caaaacgggt gtcaggaaat 240
gcaggatagg caaaactatt tgcaaggtga agacctaaag caacctttct tgggcccatt 300
cctagagttt agacttcctg tcggggaata aagtaaccca aaatttatgg agaaggcccg 360
ggactttcca ttcaagaaca atagcatctg tacccgcata a 401
<210> 307
<211> 701
<212> DNA
<213> Homo sapiens
<400> 307
ttgtaaggag ttgttatgga tgtgttcccc caaatttaga agttgaaatg taaaacacca 60
atgtgataat attaacaggc ggaggcatta tgaggtgagt aagttgtcag ggcaaagccc 120
tcaaggatgg gactaggacc ctttaaaagg acctgaagga atgggtttgg cctcttccct 180
cccttccgcc actgaggaca cagcgttcat cccctctaga gaatgcagca ggaagggtcc 240
atcttggaag ctgagacggg actctcacca gacacagaga ctgccaatgc cttgatcttg 300
aacattccag catccagaac ggtgagcaat aaatttctat tctttttgaa ttacccagtc 360
tcaggtattt tgttatagca gcactaatgg accaagacag gagtgctata acaaaatacc 420
tgaggaaact ccagtaattc atttaacctc ttaggatctg aatttcctga tattgcaaga 480
tggtctttac attgtggtct sactctgaaa ttctctagct tgtgatgatt gaacctagta 540
gcttacagaa gccccacagt ccaagatgct ggaaaaatat aggttatttt cttctttcct 600
tcaatttctg tgacaaccac taagagttat gagcataaat aatttcccta aacattatgt 660
ttcagcagtc tcattcccac tttggtttta aatttctttt t 701
<210> 308
<211> 401
<212> DNA
<213> Homo sapiens
<400> 308
tgaggagttt ttaatacagt tacttcaccc tcaaattacc aggaatgtcc cttaagccca 60
gagtcttatc ataggaaatt ctggcacttg gggatatgta gttagcctct tgggcatagg 120
tgccttccct gaggtggagc acagtgggcc actcctgccc gagcatgttg ttctatctcc 180
caaagtctgt ggctctggga rgaggtgagt gggcagttcc tttcctctgt acagcccaag 240
gtgtttccta aagcccgcat ggccaaaggg gtcactagtc ccccaggaac tcctccgcac 300
atcctccttg ccggtgagac atcccaggct gggccatgtt tagtcaaaac tgagagcagc 360
ccagcccgct cattcccgcc actctcagct gggccagcac a 401
<210> 309
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 309
taggatgaca ttatattata tctgcaactt ttatacttat aataggcttt ttatctcagt 60
gtctaaacta agtacatatt tgtgtgacat ttctttcttt ctttcttttt cttttccttt 120
tttttttttt tttagatgga gtcttgctct gtcacccagg ctggagtgtg caatggcaca 180
atttcagctc actgcaacct ccacctcctg ggttcaagcg attctcatgc cacagcctcc 240
tgagtagctg ggattacaag gcatgtgcca ccacacctgg ctaatttttt ttgtattttt 300
agcagagact gggtttcatc atgttggcca ggctggtctc aaactcctga cctcaactga 360
tccgcccgcc tcagcctccc aaagtgccag gattacaggt gtgagccact gagcccagcc 420
atggcatttc attcttagcc aaaatattaa tctgttttaa tttgattata gtacctgtaa 480
atagaattaa catggactgg yttttaaatc ttatttttca agtcaatgac acattttgct 540
ctgaaatcac aatatcatta tttattttaa caaatttcta caatatcgtc tttaaggaaa 600
ttttaatgtc atttgtgtta actttaaata atgacctcta tgtgaggaaa aggaggagga 660
gcccttttct ggcaacttct tcagccctcg atatgatctt aaactgcaag tcctttggca 720
atcgctacta agcaaactcg agtgactcct tgcctggact tgtcgtgtag tggagtgttg 780
gggagtgggc agtttaaaca tatttctgat atatattatc gtctaaacct ttttctgatt 840
ctaatttttt gtaaaagtaa acggtgctta catgaacaca gaagccattt taaaaagaag 900
aaaaatgtgg taaaaacagc tactgaagag agatgtctca atcatcctta aaatgtgtct 960
tttcccttga acagaatagc tactgagagt ttttggtttt t 1001
<210> 310
<211> 401
<212> DNA
<213> Homo sapiens
<400> 310
tgacacattt tgctctgaaa tcacaatatc attatttatt ttaacaaatt tctacaatat 60
cgtctttaag gaaattttaa tgtcatttgt gttaacttta aataatgacc tctatgtgag 120
gaaaaggagg aggagccctt ttctggcaac ttcttcagcc ctcgatatga tcttaaactg 180
caagtccttt ggcaatcgct rctaagcaaa ctcgagtgac tccttgcctg gacttgtcgt 240
gtagtggagt gttggggagt gggcagttta aacatatttc tgatatatat tatcgtctaa 300
acctttttct gattctaatt ttttgtaaaa gtaaacggtg cttacatgaa cacagaagcc 360
attttaaaaa gaagaaaaat gtggtaaaaa cagctactga a 401
<210> 311
<211> 401
<212> DNA
<213> Homo sapiens
<400> 311
aggtatgtca cccagtaacc caagaaacag ataaacagag agaaaccctg caaaagggat 60
tgagcattat tgatcttgaa aaaaggagaa gggctattaa ataacttgtt gagagctatt 120
ttctacattg gaagtctgag tgtctagaat gcttgagcaa ttttctggct gaagggattt 180
tccagttagc tactggtcat yattacatat cgaacatctc tgttgaccta aatactttcg 240
aaagttcatt acacactttc ataaacttaa tactatgcat ttaaaaagtc gttcttgaat 300
aatctcgaag attaaattcc taggcatacc aatcagaggc caaattctta ttgttaggaa 360
gtgacgcttt aacttcactg ctttccagtt tgtatttgtc t 401
<210> 312
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 312
tcttaggtct aggaatctaa ctaagaaaat gccaattcta gtctctgaaa cctttgaaat 60
actaacaatc tacactttct agtcaatcat acttctgtca gaacatcttc ctgaagatca 120
aaggtaatat tcaatacact gccttaccat aaaagtggcc atagcctgtg tacaaatgct 180
atgcctcaaa tcctgtattt taccatgaaa ttcaacaaat gatcacactt ggccttagga 240
tgtactcctg agccagaagc atggtaagta ctcataaata actgaataaa taaataagga 300
ttgtgtttta cttcgaacct caaaacaaaa aaagaataag ctggaggaat aatgtagagt 360
actctttgct ttccaagaat ggtcgtaata gaggccatgg aataagagat tgttttccaa 420
gtcaaatgca aagaagggcc acgagattaa aaacgtcaac tctaatccaa tgaatgctgc 480
caatgaaacc tctgaagaga ytagcatttt aaagaattac attacagact cttagcctgt 540
gaagcatgtc agacataatc tagagtttag acttggctct ggctctaaag gaattctcaa 600
caaaactgag aggcaccata aatagaaaga gatattacaa gaacaatgag aggggactgg 660
atagttgcaa taatgcccct ttaaaattga actaaaagat accagctgcc ttagatctct 720
caaatccagc aagcaacttc ttggactatg tctgattgtg attttcatgg tggagtttca 780
tttgttttat tacccgaaat gtaaggttcc aatttctcag tataatgcta aacagcttgc 840
tagcattctt atataaagag ggattgtgca attccagtga attttggagt tggaaaaaat 900
tcatcaatct tctcatttat ttcaatgaac tgagtcctaa gaggttacgt gtttagcagt 960
gatcaagaac cctggagtta catactatgg gtgaacgtag a 1001
<210> 313
<211> 401
<212> DNA
<213> Homo sapiens
<400> 313
actgcttgct gcgtgtatgg ccatgagcaa atttcttaac ctcacaatca gtttcctcaa 60
ctataaaatg caggtaataa tatcaacact ttcaggatta tagaggagga tcatacaaaa 120
cacaaatact tagcagcatg ctgtataaat agtaaaaatg gtcaataaat aataattgtt 180
attattgcta ttttatcagt mgtgcctggc aattagtaag cattagtaaa tgcttactaa 240
tgtcactaat tagtaacact actgttttat attaattact tttttctact gcccaacatg 300
gcagaggtta tttaagtgtt agagctagaa catggatagc taaatctctc atctcttttt 360
ctaaagactt gtattcaagt catgaaaaca ggattccctt t 401
<210> 314
<211> 401
<212> DNA
<213> Homo sapiens
<400> 314
taaagacttg tattcaagtc atgaaaacag gattcccttt cataatcata ggttgagtag 60
cattagtcaa gaattttgca ggagaaaaga gccacaattt ctgtttaatg gtagtctgtt 120
tgtaccattg ttatgcataa aaccaagaag taagcatttt tcttacagtg gagaactaac 180
tcattgaaag attgcatagc mcaaatggtg aaatattgca gcttcctgag ttaaaccaac 240
atctttttga tataatgtcg atcttttgtg gacttacgct ttagcaacta gatacaaata 300
taaggaagta gtaaagcact gcggaaaata gtgcaagatt tcttgtttgt tcattttttt 360
catttttgct ttttcatttg tttttgcttt ttctttagag c 401
<210> 315
<211> 713
<212> DNA
<213> Homo sapiens
<400> 315
ctcttctcat tgagatggtg aaaaataaaa tgagaaaata gagagagaaa atgctttgaa 60
agaagaacac tttgcatatg aaagaaattg gagattttgt ttatgatagc tcagatgaat 120
cctgccttgt ctcattgcaa cagcctgtta taatatttca ttgttggaac tgaaattgcc 180
tcataataga caagtgtcat aggacttgga tcagtagata aacactacag ggaagcctat 240
ttcagatcaa aatggtgaag tgcttttgaa catttagaga gcttttgaat atttggagcc 300
attcaaaaac aaaatgagtg cctggaaagc actgaataag ttgaaacaga gctataagac 360
cagctagcag agatgctgta gaaaagtttc ttgcactgga mcagacaaca gctaacattc 420
tatcccagta agaatctggg aattcactac aatgattttt aatgctgctt ttaaataggt 480
gaagggctgt aatgtagaag aggaagtgtt ttctttcaga ttatcagact aagcccagtt 540
gatggaaagt ataagaagac gaactttggc acaatgcagc caatgcaaca atattcacaa 600
tattcatggc atttagaaat gccatataat taattttttc aaagtcgggt agatgtgaga 660
ataatctgac caaagctaat ccaccagtgt tagacctcaa actttagatt ctg 713
<210> 316
<211> 610
<212> DNA
<213> Homo sapiens
<400> 316
ctggctctgt tctatgccac ccacagcaat gggctagata cactctctga atgccaaact 60
tgtgcttccc aggcaccctg ctgccaaaat atagctggag aaagcagcca gagaacccca 120
tagtcaaggc aagcacaaga gcttaactgg agacaagact gtggggttga aagggaggga 180
gatgaatcct cttagatgtg tgttgactcc ttcctaagtt caaagcattt atgcttttaa 240
atcatctctc ctccaagtaa atttgtggga caagctgtat tttctccact taatagacga 300
tgaaattgag gctcagattt gatttggatc atagccagtt tgcatagata gcaccagatt 360
ctattccttg gccttctcac ttcagggact ttttcctara ccacattacc agtagatgtc 420
attctttgac cagcagacaa atgccagaga gtagaaattc tagccacttg gctgaaagtt 480
caggttcagg gagtatcttc aagagaggga gggactcgag accagtgtgc ccagctcctt 540
cgcctctgcc ccacccagag ctgagggcct ggacctcatg tgccctcccc acacggtgcc 600
tactttctct 610
<210> 317
<211> 401
<212> DNA
<213> Homo sapiens
<400> 317
tagaccaggt gggttcaaat ttcccctatt ctaattttaa tttccacatg atcagaataa 60
acatggctgc cttgagatct cattttccag tgctgccaga aatgaaaatt ccacatagcc 120
tagtggacct tcccacctcc tttcactgga cagcttgctg tttagaggct cctgccattc 180
ttaacacggc agctgtcaca rcagttagcc atggaaagac ccattctctc atttgatccc 240
atctccctgc caggacagga tataggcctt aaaagtgctt cctggtgtaa ggactgagtc 300
ggggtttatt tatcctaggt tacagcaaac attacttcaa aaaacaggaa agagagtctc 360
atcttgttga ttatgatacc agttatagca atgaggtgga g 401
<210> 318
<211> 501
<212> DNA
<213> Homo sapiens
<400> 318
agaagcatca tgaccaatga ccttggataa ctccactttc ttacagcccc tgcctcaaac 60
agggattaag gaagaaaata atctctggga tgctaccttc catgaatcag ggtctagcac 120
caacaaatat ttgggtatga ttcatccagc atcttcactc tcattgtcat atttgatgtg 180
tgggacaact atatgaatta ggccagtcag ataatactac tttacagata atacaactga 240
agctcagaaa scaggtgcag ttgagagttg agccagatcc ggtttcaaat cctatctgtt 300
ttctataaaa taatggcagc ctcttctgag aatgagaatc tgccccattc atgccaccct 360
aaagagatgg tttgctttac ctgggacttc gagctccacc cttgtggcac agatgtcatt 420
cgtggaggtt aagtgttctt ggcgggcaga ggtttccatg agagctcatt tatgttggct 480
acaagactgt tcttctccta g 501
<210> 319
<211> 501
<212> DNA
<213> Homo sapiens
<400> 319
cccatggttt ttaggatcct tagccctgcc aatggttatc tgagcagggg aagcatattt 60
gttttaagca actgggagtg tagaagacat gggtgcttcc ttcctgggat ggccaggcaa 120
caagaggcat gtaagaagat ttccaaggaa gagaaggcaa gccatggggc tgagtgggag 180
caagttggtc tgctgggaag gagcagaaat actgaccacc tcaagtcctg aacacccagt 240
ggaggtcatg yctttccatg ggtggtctcc aaattctggg catgcttttt cttcctgttt 300
ccaaatagct tagcaagctt aatccatcca cacaacatgt aataagctct tctgtgttcc 360
agatatttga taagaactga aaataaatga taaagcaaga ttctgttctt aaagagctta 420
tcagaggagt aagtaacaag aaatggtgtg aatttttagc agaagcttgt aaaacatcag 480
acgagaaaaa cacgatatgt g 501
<210> 320
<211> 720
<212> DNA
<213> Homo sapiens
<400> 320
ttctgttctt aaagagctta tcagaggagt aagtaacaag aaatggtgtg aatttttagc 60
agaagcttgt aaaacatcag acgagaaaaa cacgatatgt gtgttctata tggattggca 120
gggtacatta ttttatacca actcatgacg ttccttaccc atttgatgtg tgttaaatcc 180
tagttcccca agtccataag gagctccttg agggcaggak caagactcat gtttatttgt 240
tcaacgatac ctcacccagc attaagcaca tcaaaagttg ttcactaatc tggacaagtt 300
cttcccctat ctggacatgt ggtagaatcc cactccctgc cctgttgaaa ttgggagtgg 360
tcctaggatg tgctttcact gatgaaattc gaacagggtc acttggcaga aaattagagg 420
accactgaag agtttcggcc tttctgtttg tctctctggc acgtgtcagg tgacagctgc 480
ttatcagcta gggcccggag taactctgat accatggaac aaaaccccct gccagcccag 540
tgttcatgca gcatgagtaa gatgtgttgc ttcaagccac tgaggtttgg ctcttgttac 600
cacagtgtaa cctagtccag tctgcctggt acagaagtgt tccacaaata tttgctgatc 660
tctgtactga tgcctcgatt atagcagata ggtaaggaag taaataaagt aagttggtag 720
<210> 321
<211> 501
<212> DNA
<213> Homo sapiens
<400> 321
aggccattga cattccatct ctttcagcat ttcttccact ttgaggctgc tttgtggctg 60
ctcaaactca gatttaagtt tgctgtgaac cttagcagtg aatgcctcta tctttgcctc 120
aagacttttg tagtcagaat aggcaatgca ataagtagtc ctagatagag aatggtagac 180
aatttaggga agagttaaat gagagattgt ctgaaaaagt gtgcgaagat tggaaaggaa 240
aagttccacc ragacagagc ttcccaggga ttgcagtcaa aaaccactag gaaattgaga 300
tagatggtga tgcctttagg agcttggcct ctggcatcag gcaaacccga ccttgaatcc 360
cagctattca ctcacctact gagtgactga gcaatttact gaacctttct aaccaattca 420
gtttcctcat ctgtcaaaca agagtaagga ttgagctcag ctcttagggc cattgaccac 480
ataggaaagt aattttcctt a 501
<210> 322
<211> 501
<212> DNA
<213> Homo sapiens
<400> 322
agtagtccta gatagagaat ggtagacaat ttagggaaga gttaaatgag agattgtctg 60
aaaaagtgtg cgaagattgg aaaggaaaag ttccaccgag acagagcttc ccagggattg 120
cagtcaaaaa ccactaggaa attgagatag atggtgatgc ctttaggagc ttggcctctg 180
gcatcaggca aacccgacct tgaatcccag ctattcactc acctactgag tgactgagca 240
atttactgaa mctttctaac caattcagtt tcctcatctg tcaaacaaga gtaaggattg 300
agctcagctc ttagggccat tgaccacata ggaaagtaat tttccttaat aataaggaca 360
catttttata ttatgtgctt ttaaaaggag ccttaaataa agagaagtga gatcattttc 420
cagtgcactt agcatagtaa cgacaacata gaaagcgtta aaaaaaatga cagcttaaga 480
aagcaaagga tgtggaaaca c 501
<210> 323
<211> 501
<212> DNA
<213> Homo sapiens
<400> 323
tgaaagaggg ctctgcctgg gctcagcttc caggaaactc tcaaactctt gcccagagca 60
tcgtgatgta gccattggaa cctcacgcag gcgatgatga tccttttacc agatatcaga 120
acttacctaa ccttcagcca cttaaaaatg ctctctggaa agtattcaac aagggcttga 180
gaaaccaagg agaccctgat ggaggagatg tcaaataacg tgagagcctt gttctgtcta 240
agctaatttc yggcactttc cagagagtta gaagtgattg gtcttcggtc tgctcagctg 300
actttgaagc attggccaaa gggctcggga caagcaggga gaagctggaa gtcgtctatt 360
gcctccacct gggactgcct caatgtcctt ttgttccagc tggatgtagc cccagaaata 420
gcagtaaagg aaaaacatgt gatttgagtt tccccatctc ccttttctgt gccctctccc 480
ttaccagggg atttttcctg t 501
<210> 324
<211> 601
<212> DNA
<213> Homo sapiens
<400> 324
tagccccaga aatagcagta aaggaaaaac atgtgatttg agtttcccca tctccctttt 60
ctgtgccctc tcccttacca ggggattttt cctgtgccca ggcaccccat gtttcttgaa 120
gttctgcccc agagacaatt attccctcca gtggagtgga gaaaacaaga gacttggaat 180
taaaagacac atatccaaat ctggatgctt tcacatgcca gttcttatct gattgcccct 240
gagcctcagt ttcctggaaa tagcagtaac caccccacag taggtaatta ttttattata 300
ytatagtact ttaacagatt tgggtttgat ttgaacagca gagataagaa gaattaattt 360
ctgctcttgt agatgaagcg aaatttttca accaggtaaa attccctaac ttgctcactc 420
cattaattcc tccaaccatc cattcactca ataaacatgt attctgagcc tactattgtg 480
ttaagtagca ctaattgacg agagctgaaa gagaattcag accttgggaa tgaggctgac 540
agagaaacag atggtaaagc aggagagtgg ctgcggtgtt taaagcagcc cagcagataa 600
g 601
<210> 325
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 325
cacagaataa atgcccaaca aataatagcc ataattattc ccattcttgg tcgaccacct 60
taataaaagc taccatagag gcagggaatc agtaagaaga gatgactaag aggatgctta 120
ctgcatgtag gaaaatcagt taatgctcgt gtgactggct tatttccctt tgcatactgt 180
ccttcaggtc catccatgtt gtcacatatg gcacgatttt catttttttt taaggccgag 240
taatattcca ctgtctgtat ctacccattt tctttattcg cccattgatg aacatttagg 300
ttgtttccac atcttagctc atcttgacag tgctacaatg aacatgagca tgttaatatt 360
tctccaagat catgatttca attcttttgg ataaatacct aaaagtggaa tggctggatc 420
ctatattagt tctgttttcc tctttttgag gaacctccct actgttttcc atagcggcta 480
taccatttta cattcccacc rtctgcgcca gagttcgaat ttctccacat cctcaccaac 540
actttttatc ttttgttctt ttgataacag ccatcctcac tattgtaagg tgatatctca 600
ttatggggaa aaattatatg aaaaggaagc atcaaattaa taggcaagaa aaccagtaca 660
tagtatttgg acagttggca tattacttaa aaattatgta tgaatccaaa aaattaatta 720
actcttacta tattagtatt ctgattgttg acattaacct gtaacaatag gagaaaaagt 780
tagttcagga atcacttccc aattacatct gttacaaatg caaggagaaa caaatacaag 840
gagaaactcc tttgcataca atattttaaa gaaaaggaca ggtgagtttt gggatgcgag 900
gagaggggca agaaactgtc ttctgtgtgg agagggatct tgaaacatat cttccaatgg 960
gaggccaaat gcaggggggc attgctttca agaaactaaa g 1001
<210> 326
<211> 1701
<212> DNA
<213> Homo sapiens
<400> 326
ggtcaaatga gcaaaggcac catcccaggc acagaatgtg catcctgtgg ttgttggggg 60
gagtctgtca gagtcttatt ctggactaga gtcaggactg ggtcccataa ggtcagggca 120
gggtgagtgt gaccttgggg ctacaggcaa ggccaggcat ccaaggggtc tcaactgccc 180
caaacaaccc catcctgcca ggccccactc cccctgtccc tccctcccat tgttcagtcc 240
cctcaccccc tcaccatggg cacctgcagt ctcattcaga gacaccctca tcttagagtc 300
cctgatagtg gggagtttgg cccctcagag gccttggttg ctttggtcaa tccataatgc 360
ctgggcctgg gacccccacc atttcttgtt catcagggac acagcagctg tgaaggcagc 420
tgccttcacc agagcagcga tgtagcccag caagggcagg gacagagacg caaggtctgg 480
gggatttttc cacaatgctg cagaaagaaa gtccctgtgg agctcagtct cagccatccc 540
tgccccagct gtgagctgaa ctgaatttca ggcatctcag agtcccttca cctttgcatg 600
acccatttcc aggacatgac aggtcaagcc catgggagag gggatcaccc aggtctccct 660
catctccatg gacctcctgg gaacattgcc agggtccact ccacccctgg acgctgtccc 720
caagcttcac cctcttttta taagttgtac atttttatta tgaagatctt tgaacacaaa 780
aatagggaga tgaaagaata ataatgtccc caaggttccc atcaccgagt ccccataatt 840
tttgattttc aaataatgtt gactcaccca caacagagta aacgattccc tcagacaata 900
gtctgaagca gatgcgaaag ccatcacaaa cttaaatgga gagaatcaat gatttcttga 960
cacgaaaaaa cagttaacga gggtctcacc aaatgtcttg tgaatttcat tgtgtatatt 1020
tttagttgac ttcgtggtgc attacgtatt tgtggattta actttagttt ctatgtggag 1080
taaatacttg atgttatcag tggtgaatgt gtttttagac ccattctatc tacagctgtc 1140
tcccaaatgg ctgtcaggct tttcctggca aggcaggagt ggcaggagca gagagctggt 1200
cctgagaccc tcccacagtc aggatgcagc cactgcctcc ctgagcagga acccagtgct 1260
tcctttagct tctcttttcc tgaaaaattg ttctagcatc aagaggctca gtggggttca 1320
ggctggacat tggcataact gcttcctagg acatgtggtt acttctagca aagccaccca 1380
tgttcatcat tcttttagtg acrttagctg tgtttgatga tcgataactt tgtgcttcag 1440
ataaaaagga agacagaggg ttgaggcttc cattcacctc ctcgtgagag ctgcagtgtg 1500
tcgctgaagg gagggcccag cagctgtgct atgaacctag gagtgtgctt cctgctttgg 1560
aaaaaaggaa gaaaagtagt ttcttccctt ttattcacca ctttgataat ggacgatctg 1620
gtgctcggcc atactcgagg gtgaacagaa caacatagag ccagagtgag ctccagcatg 1680
tgaggacatc tgacatgtgg g 1701
<210> 327
<211> 2000
<212> DNA
<213> Homo sapiens
<400> 327
ccgccacact tcagcacaaa caggaggagg tggccgtcta gagtctggag tccggggaga 60
ggaggaccgc tcctctcttg gagaccaccg ctgtcactga cgtgtccacc acccaccact 120
ggcagtgcag cccctgataa tgccccataa ctcatcccca tctaggatac tgcagcaccc 180
gatggtgccc acaacctgcc ccctgccatt ggcagtgcag cccaggttaa tgcccccaaa 240
ctgctccctg atgttggcag tgcagccacg gaaagtgccc ccaaccagcc tcccgccatg 300
ggaagtgact cccgggatag cgcccccaag cagaccctag ccttgggcag tgacgcccgg 360
gtaggtcgcc caaccgccac ccaccccgtt gccgagagtg cagcaccaga tagcgaccct 420
aacatgcccc ccatcactgg cggtgtagcc caggatagcg ccgccaaccc ctcacttgac 480
gcgacagtgt agcccctgat agtgcaccca atctgccacc cactgccggc actgcaaccc 540
cggatagtgc acccgacaca ctccctgctg ggcagtgcag ccccccaata gcacccaacc 600
cgtccctcca cccctgccac tggcagtcca ctcccgataa tgcccccaac acgttcctgg 660
ctgtgggcag tgtagtccat agatagcgcc ccaaaccagc ccccagccat gggcagtgac 720
acctcagata tcacacccaa ggagttcccc accatgggca ctgatgtccc agacagcacc 780
ccaactcgag cctcgtgtga ccaatgcagc cacagatagg cccccaacaa gcccccaccc 840
caccactgct gcaggaaatg atgcctggga taacacccaa ccattcccca ccgtgggcag 900
tgcaacaccc agtactgccc ctaacacacc ccccacacaa gatggcgccc ccaatccccc 960
cctcaccttg ggcagtgtag ttcacgatag tgcatccaay ccttggcccc tgagctcact 1020
gcccctctcc ccccgccaca agtccctgga tagctcacct actctgccac ctttctacca 1080
ctttggctgt gctgtactct acctcactgc caccagccac agtgaggcga gccatgctgc 1140
tgcaggctca agcctccagc atgccaccgg tgacaactcc ttctctaatc tggggtcgga 1200
acagatgggc gggcagacgt agaagaacct ggaatggcaa gactctcgct tacaaaggtt 1260
atgcaaatta ggttcctgga ctacatgttc tgattggatg agagaaaaat ctctaggtct 1320
actatgattg ggctttattt tcgtgttgtg actggatgag aggaagtctt aggataacca 1380
atcagaacat gataacaaag tccaatcaga ctaggcctag aggtttctct tgtccaatca 1440
gaacatgtag tccaggaact tcatttgcat caactccaca tataaaggat gccaagtgag 1500
gcggctcctc attctaggct cttcagtgtc cactggtgta gctgctccat tccaggctta 1560
caggagaagg aggaggaggc acttgccacg cacgctggag actcgagcct gccttggctc 1620
cccttgctgc tgtggttggt ggtggcaagg aagacgacag tgcagccagg atggtaaaaa 1680
ggtggtggga taggttcgct atcccaggag gtactgcctg aggcatgggg ggtgggttgg 1740
ggtccctatc cagggcgtca ctgcccgtgt tgaggggctg gttgggtgtg ctatctgggg 1800
catcactgcc tgtggagggg agtgggttgg ggccctatct ggggtgtgct gcccgtggct 1860
gggggtgggt tggggcacta tcccaatctg tactgctagc ggcagtgggt ggttttgggg 1920
ggcactatct ggggatgcac tgcctgcggc cagggggtga gttgggagaa ctatcgggtg 1980
ctgcaatgcc cttgttgggc 2000
<210> 328
<211> 1001
<212> DNA
<213> Homo sapiens
<220>
<221> misc_feature
<222> (501)..(501)
<223> n is a, c, g, or t
<400> 328
gttggaatca tttacttgca gagaggtgtg tgtgtgtgtg tgtgtattta tgtgtgtact 60
catgtgtata agaataggag aaacactttg tgggcatatc ctgctgaggt gagtaacgtg 120
ctgattagtg aactccagtc tcatcccatt taaacctgga ggagaaccac atcaagcaca 180
gaagcagcca aagcagcatt tcaacaggaa ggaaacatct attactgggg ctttgaagaa 240
acatgccatg aaggtgtact aatatcacaa agggaaggga aggactaaat tcagcatgat 300
aaacaaagtc ccttttttgt aacggaagtg tttgatgatg tttgatcaat ggtggatcta 360
tctcttgaaa ggaaaatgca tttaaacccc aaatggagga ttcttatata aggtgcctag 420
cttgtaatga tatattcatg tttataggta gagtgactgg tttttagaga agaggttttt 480
ttttttcctt catttttgaa ngaaaacttg tctgtctcta ggctttgaaa tgtagaatta 540
tttacctttc cccaaaatga aatgtttcac tgaatctcct acaagcttgt ggaggccatg 600
aagcatgttg aataagagca caggctctgg aggccctgcc acccacaaag ggtgtgctaa 660
ggtaaacaac tgatagtatt ttgaaaatta gatgacttag aatccattca ataaatttta 720
gctattttta ttgtcttttt tttctaaatc tatttggaaa atattgcaga taaagtagat 780
aatacctttc taaaacacag tgagaccagg cgcagtggct catgcctgta atcccagcac 840
tttcggaggc cgaggtatgc ggatcacgag gtcaggagat cgagaccatc ctggctaaca 900
cggtgaaatc ccgtctctac taaaaataca aaaattagcc aggcgtgggg gcatgcgcct 960
gtaatcccag ctactcagga ggctgaggca ggagaatggc g 1001
<210> 329
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 329
gatgggaaac aacaggccat gattttatgt ttttgttaaa ccagtataat tctttcaaag 60
cagtgtatat cacaactatt tctctgtgtt gaagagagta tcaagttctt aaagaaaaat 120
gtaatcccag cactttggga ggctgaggta ggaggagcac gaggtcagga gttggagagc 180
agacaggaga attgcttgaa tccgggaggt ggaggttgcg gtgagcagag atcgcgccac 240
tcactccgtc ctgggtgaca gagtgagact ccgtttcaaa aaaaaaaaaa aagaaagaaa 300
gaaagaacat tttctattct gcaggtggga ggaaatgaag aatgcaccta ttatttttgt 360
gttagtacaa cataaaaaaa atttgcattg taaagcaaac taccatcatc agctctttaa 420
tggacagcag cagacaggaa actgcctcca ccctgagact taaagactga gcaactgagt 480
tagatagcag gtgcgcaggc yaatcaagtc aattttctaa cacagagtag catgttgtgg 540
aacttgttct attagtcttt tttctctgtt aaggaagcaa ggatctctct gtatggaagc 600
agtgctgcta tttctagttt gaggaaaaaa atggtaaaga atttgataat taattgttgt 660
taaaacagca aattatattt taaacacaga ttgtccacac ctgtaggagg aggaatctca 720
agaatgcaca caattaataa aagctggttc tgaattaccc atacaagtgc gcactgcgtt 780
cagtaaacaa ctgatttgca aactatatcc tttctttccc agaaatagca ggaggaagtt 840
tttcaaatca aaaaaaaaat ctaactaaaa tattttatac gtgaaggcct gcagaatttt 900
acttcctttt gctgttgaaa aatcacaata gccaagagga gtaatgtatt ttattttaac 960
ttttaaaaag tcatgatggt taagggtaga gtggaggtgc a 1001
<210> 330
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 330
tgttgcccag gcttgtctcc aactcctgag ctcaagagac ccacccactt ccgcctcgca 60
aagtgctggg attacaggtg tgagccaccg cacccagtca cattcctttt aacacttggg 120
ttacatctcc tgaactgaat ggctaggtaa ctaaagacat ctgagaaagt ttcttgcacc 180
tatacattaa gccctcttta ccaagtcata taacctatca ctatctattg aatcttccca 240
tatgagctct aaaggctatt gttatcacaa aacacaatgc caacttttga gtgattaagt 300
atccttctca tctataagag gatgttgccc agactaatct caaacttctg gtctcccgcc 360
ttggcctccc aaagtgccag gattacaggc ataataaaac tccttgatgc catcttccta 420
gaaagatatg cttagcctca ttcaatccaa atagttcctg catttctttt gcatgagatg 480
taagacattt tctgacataa mataaaccaa ataactcaac tacattcatt tttataacaa 540
cagctttttg aaatataatt cacatacaat aaattcatcc ttttaaagca tataattcag 600
tgggtttcag catattcaaa gagttgggca atcattacta tctaattata gaacattttc 660
atcatcacca aaagaaatct catacttatt aggagtcacc tccctcccat ccctagcccc 720
tagtaataac tagccaactt tctgtctcct tagatttgcc tattctggac gttacttaaa 780
attgaaagca tatcatatgt ggcctttctt gtgcctctca gattcaccta tgtgacagca 840
tttatcaata atccattcct ttatactact taataatatt tcactgtatg gatataccac 900
aatttgttta ttcactcatg acatgataga catctgggtt gtttccattt tttaccatta 960
ttaataatgc tgtaatgaac atttggctac aagttttcat g 1001
<210> 331
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 331
tacacaatat aactagtatt gacttaaggg tactgtgatc accatgcagt gatcccataa 60
aagatgtgac caaaataccc acttaaaatt tgaacgtcag tcatgtaaga acatgtaaaa 120
gatgaaggga atatttcaaa aacgactatc tgacgtaata tgatacttac tatgactcat 180
atgggctttg ttcttcatct catcttcaaa taaaaagttg atgattagaa aaaggagcat 240
tagaaggggg aagtaacact actcggcaat agagaaaaac tccggtcaaa ggaagagcat 300
agttacagag ctccgaatgt cagggaaaat caagcatccg tcattcggaa ttagctctgt 360
atcggtcggt ttcttcatta cttaattgta cggggggaaa ctacttcaaa gtaagggctc 420
ttacgagagg caacttaagc atttgaaagt gcaggtttat ttcctcctag cgagaagtag 480
ggggtcacta gtgagaaacc yatttcaatc tgtgagacgc ccccttctac tcagcccacg 540
tggctaaagt aaacagaagg tgggccgggg cggggagaaa cagaactcgg tcaatttccc 600
agtttgtcgg gtctttaaaa atacaggccc ctaaagcact aagggcatgc cctcggtgaa 660
acaggggagc gcttctgctg aatgagatta aagcgacaga aaagggaaag gagagcgcgg 720
gcaacgggat ctaaagggag atagagacgc gggcctctga gggtaaggtg ggcgcaagcg 780
gaggtgtggt gcggggagag gtgccagtgg gtggaggcgg gggccagagc gagggcacgt 840
gcgggtacac tccggaggag gtgggtgcgc gcgggggcgt gtgcgcggga cctcgaagtg 900
gtggtggagt gcagaccagc aaaaagtttc aaagggaaat cttagatgtc acgtctttgt 960
ccaggcaccc gtgccatccc aacctcccac ctcgccccca a 1001
<210> 332
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 332
acaaagatga ctctttccag cgatttgaaa ttgctagata agactatgaa attctattaa 60
aacaataaca acaaaaacaa tttaacttgc attagaagca attaaagcat aaaaagtaga 120
tctaagattt tctaaatatt agatattcta aaatattgac attatacaat gtctagcatc 180
cgtaactttt gaagatattt tatttcaagg taatttcata agaattcata agaatttacc 240
tactcagact ttgggcagga tggaaaatag agtttctgtg aggtgtgcct atgaatcata 300
agaagggctt cttaatgagg tcagtaatta aggaaataca tttcaatagt gacatttgac 360
ttacaacatt gtttgggggt ggagtcttag aagaattgat agggaacttt taacttcaac 420
aagtgaaact aaaacattaa ctccagttgt tgttacctaa tacaagacca gtgcccaata 480
aggactttgg aattctttca yaacaactcc ttggcaggtg cacttcactt gttctggaag 540
tgatattcac ttgccaatgt ctagtaggac catgtgccac tgcctcaaaa tcatatcaat 600
tcctccggct tctggcataa actggcacat cagacctaat taaagcctta agaagagttt 660
ggcaaatatg acaatttaaa caaagcaagg gatttctctc actgcaactt aatttctcat 720
tgatgattag ttcaataaga aaataagcaa aacaatgtca tagttaagaa aagctatcta 780
tcttgttatt gtccattatc atgttcctaa aattcaataa cccaagacag tcctatggaa 840
tttttggagc acctaggtag tatgatcaca tatatggtaa agaaagaact gaggttatgt 900
cttttattgt aaactacccc atacttatta aaataatttc tcttttccaa caaaggataa 960
agtgactaac atacacatct cttccttata atcactgaaa t 1001
<210> 333
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 333
cagagagtaa agcctaaggg gaaagtttga caggctggtt gtatttatgt attcatcctg 60
ccacatcctc gaaaaaggta tttattgtta agtaggttca aaaacatctt caagaccaga 120
aaatgccttc ggacgccact gggctgttga attccttagt tattgattca ctaatgtcat 180
catgaaagaa tttatgattt tcccaatcca gtccaccagg agagggaagg ccttgataag 240
gatttagatg ataaggagaa gaattgccaa gattgaagac ccagagcaac agcaaagaat 300
tttggaaaag aaatttcacc aaagagtaaa gttagtgtta ttttggttat gtggaatatt 360
agagtgaatt aagtagagga ataaaatcac taataaaatt ggttagcaaa ggcgtcataa 420
aatcacacca atgagaaaca gagtgctaac ctagactttg tatatcttca gtttcctttc 480
aagcatttca aacctcccca rttagcttca agtttatcct taggtagatg tgtacaaaag 540
atttcttcaa ctactttcta gtattcaaga tattatttaa gggaaaaatc acatttattt 600
attcattaga tattttggta agtattctag gtgctggatt aaaagagaga aatggctcac 660
gcctgtaatc ctagcacttt gggaggccga gatgggcgga tcacttgaga tcagaagttt 720
gagaccagcc tggccaatgt gttgaaaccc tgtctctact aaaaatacaa aaattagccg 780
gaaatcacct gaacccggga ggtggaggtt gcagtgagcc gagattgtgt cactgcactc 840
tagcttgggc gacagagtga gactctttct taaaaaaaaa agttaaaaaa ataaaataga 900
taacatgtct tatttttcct caggctctgt ttaatggtgg tgatgatgac atgatggtca 960
tcactaccat ccattgagta catgcaccaa gtcatcatgt t 1001
<210> 334
<211> 10187
<212> DNA
<213> Homo sapiens
<400> 334
tgactgtcat gtgctaattc taacaatatt tgaaagaccc ctatcaaaat aaatatacct 60
tttagtagcc actttattag aaaatcaact ttaagttatt cccccatgtt tttttctaat 120
tgagatataa ttcacatacc ataaaattta cccttttaaa gtatacaatt cagttgtttc 180
agtacattca caaagctatg caaatgtcac ctctacctag tttcagaacg ttttcatcat 240
tcccagaagg aaaccctgta tttattaggc agtcacttcc ccttctcccc ttcttccttc 300
ctctaagtgg caaccacaaa taaacattca gtttctctgg atttacctat tctgggcatt 360
ttgtattagt gaaatcatgt atttggcctt tctctctggc ttctttcatg tacctcaatg 420
ttttcaagtc tcattcattt tattaaaaaa aaaaagtacc ttttttcttt ttcttttttt 480
tttttttgtc cacgtatata ttcacaccac attttttgag acagagtctc gctctgttgc 540
ccaggctagg gtgcaatggt gcaacctcag ctcactgcaa cctctgtctc ccgggttcaa 600
gtgattctca tgcctcagcc cccaagtagt tgggattaca gttgtgcacc accacaccca 660
gctaattttt gtatttttag tagagacagg gtttcaccat gttggctagg ctggtctcaa 720
actcagcctc aagtgatcct tctaccttag cctcctaaag tgctgggatt acaagcatga 780
gccactgtgc ccagccacat tttctttttc catttattag ttaattgaca tttggatcgt 840
ttctactttt tggcgattat aaattatgct gcaatgaaca tcggtgtaca agtttttgtg 900
tgaacatgtt ttcagttacc ttgggatata cacctaggag tgacattgtt agtaatatgg 960
taactttatg tttaactttt tgaagaactg ccaaactgtt ttccaaagta gctttatgct 1020
tttacatttc tgccaacaat gtatgaaggt tccagtgtat ctccacatcc tcaagaaaat 1080
gttattgtct ttttaattgt aaccatccaa gtgggtatga agtttatctc gtgattttga 1140
tttgcatttt cctaatggct gatattgggc atcttttcac gtgtgtattg accatgtatt 1200
tttttgagaa aagtctactt atatgttttt aattgtatta tttttagagt tgtaagaata 1260
tgttatgttg atacttgaac tttgtcaaat gcctggtttg cagatatttt ctcctatccc 1320
acaggttgtc gcttcacttt gataatgtcc ttaaagtaca aaagttttaa attgattttg 1380
atgaaactca atttcttttt aattggcagc ttgtgcattt ggggtcatat ttaagaaatc 1440
attgcctcat tcaagatctg aaagatttac acctatgctt tcttctcaga gtattataac 1500
tttagttctt acatttagat ttttaattaa tgttgagtta atttgatggt gagagataag 1560
agtccaactt cattcctttg caagtagctg tccagttttc tcagcaccat ttgttaaaag 1620
actgtttttt ttcaattaac tgaccaagat gtatgggttt atttctggac tcttaattct 1680
gttaatctgc atgacttttc ttatgccagt accacactgt gctgattcct gtagttttgt 1740
agtaaatttt gaaatcaaga caggtaagtc ttccaacttt gtacttttgc ctaccatgtt 1800
tcttgggttt ccatatgcat tttaagatca gcttctccgt ttcctttctg gatttttttt 1860
tttttttttt tttttttttt tttggtggag ctggagtctt actatattac ccaagctggt 1920
tttgaactcc tggctaaaga gatcctccct cctaggcttc ccagagagct ggggttacag 1980
gcatgagcca ccacatccaa cccccttctg ggactttgac tggggttctg ttgaatctgt 2040
tggtcaattt ggagagtatt gatatcttaa cattaaagct tccaatttat gaacacaggc 2100
tatttttcca tttattctta aatttctttc agtaatgttt tggatgaaac atgtacaaag 2160
tcctgcactt tttatttttt ttaagacaga gtcttgctct gctgcccagt ccagagtgca 2220
gtgctgccat ctcagctcac tgcaacctcc acctccgggt tcaagtgatt ctcctgcctc 2280
agctggaact acaggtgcgc gccaccatgc ctggctaatt gttttgtgtt tttggtggag 2340
acagggtttc accatgttgg ccaggctggt ctcaaacacc tggcctcaag tgacctgact 2400
gccttggcct cccaaagtac tgggattaca ggcatgagcc accacgcctg gcctgtactt 2460
ctgttaaaat tttttctatg tatttttttt atcctattgc aaaatcaaat tttttgttga 2520
taatatatgg tcataaattt catttttata tattggtctc atatcctacc aacttgctga 2580
actagcttat tagcactaac tttttttggt agattcctta ggatttgctg catacaagat 2640
tatgtcatct acaagtagag atagttttgt ttcttcactt ccaatctggg tggctttatg 2700
tttttttctt gcctgattac ccagttagaa cttccagaaa atgtcaggta caattaacaa 2760
ctgcaaacat ccttgtctta ttcattttag aaagaaattt ttagtttttc accattaagt 2820
atgatactag ttgtaggttt tgtttaaaaa aagactgtgt caagttcaga agttcccttc 2880
tgttgctagt ttgttgaata attttatcac gaaagggtgt tgaacttttc tcaaatgctg 2940
tggctacatc taatgaaatg atcatgcgtt cttctccttt attctattaa tatggtatat 3000
tatattgatt catttttata cattagatta acattatatt tctggaataa atcccacttg 3060
gcctcagtgt gtattacttt ttatatattg ctggagtctg tttgcaggta tttcattgag 3120
gactttcgca tctctgttga taaggtatac tgatctttag ttctcttgtg atatctttgg 3180
ttttggtgtc agagtaattc tgagttcaca aaatgcattg ggaaatgttc ccttctctat 3240
cttttggaag agtttacaaa ggattggttt aactcttttt taaatgtttg aggaaattct 3300
ctacccctgg gctttccttt gtgggaattt ttaaacattt ttaaaataga ttatttttaa 3360
agcaatttta gggtaaaagc acattgaatg aaaggcacag agcttcctta agtacatgct 3420
gcccctgtat gtgcatagcc tccctcatta tcaacatcct ttaccagaat ggtacatttg 3480
ttgcagtcaa tgaacctgca ttgacaattg tcgmtgaaag ttcatagttt agagttcacc 3540
tttggtgtta tgtattctgt gagtctggat ccatgtttaa tgatactcat tcaccattac 3600
agtatcattc agagtaattt cactgcctta aaagtcctct gtaccctacc tatttttctc 3660
tcctacccca ctaaccctta gcaaccaatg atctttttat ctcaataatt ttgcctattc 3720
cagaatgtca tatagttgga atgatacagt atatggagcc ttttcagact ggtttttgtc 3780
acttagtaat aagcttttaa attttccacc atgtcatgat cgttcatttc ttttcagcat 3840
tgaataatat tccattgtct ggtttatcac agttgattta tccattcaca tagtgaaaga 3900
catcttagtt gcttccaagt tttgacaatt atgaataaag ctgttataaa agtatgtagg 3960
tttttgtgtg gacaaaagtt ttcagctcct ttgagtaaat aacacagagc acagtagctt 4020
gattgacagt aagagtaaga aatatttttt ctcagtctgt gtcttatttt ttcattcact 4080
tgacagtgcc atttgcagaa caaacagaaa gttttaattt taatgaagtc taggttatca 4140
gttaattcat gaataatgtt tttggtattg tatctaaaaa gtcaacacca aggtcatcta 4200
tatgttctgt gttatcttcc agaaatttta tagttctgca ttttacattt agggctgtga 4260
cccattttgc attaattttg caaaagctat aaagactatg tatagattca cttgtttgca 4320
tgtggagttg tccagttgtt cccgtaccat ttcttaaaga ctatctttgc tttattgtat 4380
tacctttgct actttgtcaa agatcagttg attataatta agtggtctgt ttctggactc 4440
tttattctgt tccattgata tatttgtcta gactttcacc aataccacac tatcttgtta 4500
acttaggctt tagagtaagt cttgcaatca tgtagtgtca gtcctctgac attgtttttc 4560
tccttcagta ttgagttggc tattcttttg cctattacta agtaaaaaaa gcagtctgaa 4620
aaggctatat atacagtcat ttattggtct tttgcctctt gatataaact ttaaaattac 4680
tttgtcagta tcctcaaaat cttgcaggaa ttttgataga ttgcactgca tttctagatt 4740
gagttagaaa tactgccatc ttgacaatac acatcttcct atccatgaac atggaacatc 4800
tctttcttgg atatccttca ttagaatttt gcattttccc catatagacc atgtacatat 4860
tagatttata cataaatatt tcatttgggg gggtgctaat ggtaatgtat ttttatctca 4920
gattctgctt gtacattgct ggtatgcaga aaagtgatca acttttgtat attaaacttg 4980
tttcctgcaa ccatgttata taatcacttt agatccagtt tttttttttt tggtcattct 5040
ttcatatttt ctaggtgatc atgtcatcta gcaaagacaa cttctttcta atctgtatac 5100
cttttatttt cttgtcttaa tgtattagct agcatttcca gtatgatgtt gaaaggcatt 5160
ggtgagaggc aacatacttg ccttgttcct gatctcagca ggaaatcttc aattttatgt 5220
tagctctatg gttttgtaga tattctttat ttacattaaa tatgttagct gtatggtttt 5280
gtatatattc tttatcaggt tcaggtagtt cccctctttt cctagtttac tgagaggctt 5340
ttgaaaatca ttaatcagtg ttggattttg taaatacttt ttttccacct attgatatta 5400
ccatatgatt tttctttagc ttattaacga aatggattac attaattgat tttcaaattt 5460
tgaactagac tggcatacct ggagcaaatc ccacatggtt gtgatacatt atttatgaat 5520
gcattcatgg tcatggttgc tattagtctg tagttatctt ttattgtaaa gactttggtg 5580
ttggtattaa ggtaatgctg ccctcataga ataagttatg aagtattttc tctgcttctg 5640
tcttaattga gattgtagag aattcatata atttcttcct taaaactttg gtagaaatca 5700
gaatgaacca tctgtgtctg gtactttgtt ttgaaaagtt attgctgatt caatttcttt 5760
catagatata ggcctattta gattattatt ttgcataaat attggtagtt gtgtccttca 5820
aggaattggt ccatttcacc ttgattatta aatgtgtggg cacatttgtt cataatattt 5880
ctttattatc ctttgttttt gagacagggt ctcactctgg ttgcccaggc tggagtgcag 5940
tagtatgatc tcagctcact gcagccttga cttcctgggc tcaagtgatt tacccacctc 6000
agcctcccaa gtagctcgga ctacaggcac atgccaccat gcctggctaa tttttttatt 6060
attattagag atggagtttt cctatgttgc ccagtgtggt cttgaactcc tggactcaag 6120
caatctgcct gcctcagcct ccaaagagtg atgggattgc aggcatgagc catcacacct 6180
agcctgatgg cagaactttt taggaacaat agaatggtat atggcatttt caaaaattgt 6240
tttcccctcc tcctatggaa gcatgaaggg atttttctct agtattcatt gtgagaacct 6300
catctggctc ctgaatgtag aaaactcaca aaactgtgag gaacctatta tgactggatg 6360
cctttggagt tgttcacact gaacctccag caattcatca attatatttc agattttcct 6420
atcccaacac tggttcctac agaggtttct gctccagtaa gctgtaattc tttttatcca 6480
tctgcttcct tggttgtgag ggcagtgatt ttccctgtga cctcatttct ctgacagatc 6540
taagtagtct tgattacatc ttttaacctg ttgtaggtat attcagattt tctatttctt 6600
cttcagtcaa ttttagtagt ttgtgttttt ctagaagttt gttctctagc tctgctttag 6660
ctccatccaa taaaatatga gtatgtcgag ttttcattta caacaaggta ttttctaatt 6720
tctatcatgt ttttttgatt cctgactgta taggagtata tttttaccta ttacccaaat 6780
ttgcttgtta ttcatgtata attttatcag aaaacacact ttgcacaatt tttgcagtgt 6840
tacatttatt tagacttgtt ttataacttg acatacagtc catcctggag aatgtttcac 6900
gtgtgcttga gaagaatgtg tatattcagc tgttggtggg tggcatgttt tatagatgtc 6960
tgttagacct agttggttta tagtgttttt tacaacttct gttttctttt taatcttcta 7020
tctactttta gccattattg aaagtggatt agtaaattat ctatttattc ctttaattct 7080
gccatttttt gcttcatgta ttttggtgct ctgttgctta ttacatgtat gtttacattt 7140
gttacatcat tttaatggct tgaacttttt attataaaat gtgtatatct tgtagatatc 7200
gtatagttaa atctttttaa aaattgatat tgctagtctt tgccttttaa tttttcaatt 7260
tatatacatt taacataatt attgataagg taggatttgt ctgccatttt gtctgtatct 7320
tgtctttttt tgtgttcaat agatattttc tagtgtactg ttttaattcc cttgtctttt 7380
actaaatttt ttgatgttct taatggtttc cctggggatt acaactaact tataacagct 7440
agtctgaagt aataccaatt tcattacaat ataaggaaac tttgttccca tatagctaca 7500
ttccctcttt ttactctgtg ctattataca aattacattt tattttatgc ccattaacac 7560
agattatgtt ttttctttta aatcagattg atattgtcat ttaaatcaaa tatgagaaaa 7620
atagttacaa aaaaatacat atatgatttc atatttacct atgtaattat ctttactggt 7680
gctctttaag ttcttaggtg tatttgaggt actgtctagt gtcctttcct ttcagcctga 7740
agtatacatt tagtattttt tgtaggacat gcctgaaaac aataaactct tatttatcag 7800
agaatgtcct aatttattat ataatacatt tctgaaagat agttttgcaa aatacagaat 7860
tcttggttgg cagtcttttt cttgtggttc tatgtcattc tactgccttc tggtcttcat 7920
tgtttctgat cagagatcag ctattaatct tattgggaat cctgcataca tgataatcat 7980
acagttttca tgattttctt gtgttggctt tcagcagttt ggttatgatg tttatatgta 8040
tgcatatctt tgggtttatg ttacatggag ttagttgagc ttcttggaca tgtagattga 8100
tgttgttcat caaatttgag aagttttcgg ccattatttt tcaaatattc ttcctattct 8160
ttattcttca tcctctactt tggggacctg cattatgtct atgttggtat gctttatggt 8220
cttccacaga tctctgaggt tctgtttatg ttttcatttt tcagactgaa taatctcaat 8280
tgacttatct tcaagtccct ttttcccctc cttttcaact ctgctattga acccctctaa 8340
tttttactgc agttattaca ctttcagctt tagaattcta tttaataata tctttttctt 8400
gagtttatct catgtattta ataaaatgct gtagtcttac tttagttatt taaatacagt 8460
tttctttcat tatttgggca tacatgaaat agctgactta aagtctttgt ccagtggcct 8520
aacatctgga ctttttcagg aatagcctct attgactact ttataggggc catactttgt 8580
ttctgtttct cttaattgtt tagacatttt aaactaatgt aatggctgag agcagtggct 8640
cgtgcctgta atcccagcac gttgagaggc caaagcagga gcatcactta agcccaggag 8700
ttcaagacta gcctgggcag catagtgaga ccctgtctct acaaaaataa aaataaataa 8760
aataatataa tctggtaaat ctgaaaatca gattctaccc cctgcccaga atatgttact 8820
gtttctggtg gttgttgttt atttcttttt aactactcct ataaagtttg tattgtttct 8880
catagatagc catcgaagtc tttgcttggt taacttagag gtcagctaag gattagacag 8940
aattccttag gtgcctgaga tcaataagtc agtctttgac aaaggggtct gtatgtgtgt 9000
tggggcatgc attcaacact cagccaggct atttgcagct ctggattagc ctttattccc 9060
tgcttgtgca gagtctcaag gttagactgt ggtgagagtt tagggctttc tgaggtcttt 9120
tgtgggccct acagttgcat gtggctttct aaattcccag gaatatattt tcaaagcctc 9180
ctgtggatca tctcatttcc caggtaattt acttttaagc ttttttagtt atcttatgtt 9240
ttgctccagt tattagctac acctgagtca gtgacaatat tcaacagctg cctatgatta 9300
tttgacaaat gcctctgtgg aaaaggtggt tcacactagg tgaactccaa gttagataaa 9360
gtaaagataa ccttactagt gggatcttcc aggaaactac caaacaggtc aaataatgta 9420
aggtctctgt gaatgggact ttagagtata tccaaccagt ctagagtata tccaaccaat 9480
ctggcctcct ctagtggcag cctggctgct gcttttcata ataaatgtgg gctgttttga 9540
tttgaaggct accatagagc tgtggggaaa gttaaaatac cacagagctc actcttctca 9600
ctgaaatcct gtcttttttt cccttgaaca aattctccct atattgctgc aagctttttg 9660
ctaatttcca gatctgaaaa agctgattct gacaatattt atcagtactt ttattgcttt 9720
tatggaggat aaaattttca gagatcctta ttctgccatt tttgctgaca tgtgtaaagt 9780
gatcatttct aattgtaaaa ttccttttgc atttattagc tggaatactt tacaggactt 9840
ttcctcatca accgttagtt accatttaat atagtttgta agaatgatag aataaatgca 9900
tggcaagaat ctttacttct caaatttcag agattttgat gggaaattat atttagagat 9960
cacaatcagt gtctagatgt gctccctgct atggaggtgt cattactttt aggctttttt 10020
aatgggcaaa tacatgaagt aattattttt tagaaagaaa atctgagatt aactcaaatc 10080
attaattcat actgattttt cctattcata gttgacagag tattattatc ttttgttctg 10140
cttctcttgt acactgaaat tcttggtttt tgatattaac aattatt 10187
<210> 335
<211> 3249
<212> DNA
<213> Homo sapiens
<400> 335
gcatgagcca ctgcgcctgg acttacaatt tcttaaaata agacaacagt gaggtttacc 60
acatcaattg accctttctt tcatgagtga tttctctgtg gcatgcaatg ctgtttgata 120
gcattttact cacagtagaa cttgttttaa aattggagtc aattgtcttc agccctccca 180
ctgctttatc aggtaagttt acgaaatatt ctaaatcatt tgttatgact caagggacat 240
taaaaaaaaa agaaaaacaa tcttttattg tcatttcaac caggttcaca gtgtcttttt 300
tttttaaatt atattttaag ttctagggta catgtgcaca acatgcaggt ttgatacaaa 360
ggtatacatg tgccatgctg gtttgctaca cccatcaact catcatttac attaggtatt 420
tctcctaata ctatccctcc cccagccccc accgcccgac aggccccggt ttgtgatgtt 480
ccctgccctg tgtccaagtg atctcattgt tcaattccca cctttgagtg agaagatgcg 540
gtgtttggtt ttctgtcctt gtgatagttt gctgagaatg atggtttcca gcctcatcca 600
tgtccctgca aaggacatga attcatcctt ttttatggca gcatagtatt ccatggagta 660
tatgcactac attttcttaa tccagtctat cattgatgga catctggtat ggttccaagt 720
ctttgctatt gtgaatagtg ctgcaataaa catacatgtg catgtgtctt tatagtagca 780
ggatttataa tcctttgggt atatacccag taatgggatt gctgggtcaa atggtaattc 840
tagttctaga tccttgagga atcgccacac tgtcttccac aatggttgaa ctactttaca 900
ctcccaccaa cagtgtaaaa gtgttcctat ttctccacat cctctccagc atctgttgtt 960
ccctgacttt ttaatgattg ccattctaac tggcgtgaga tggtatctca ttgtggtttt 1020
gccttgcatt tctctgatga ccagcatgtt cacagtatct ttatcagaag tagattccat 1080
ctcaagaaac ttctttcttt gctcatccat aagaagcaac ttctcatttg ttaaaagttt 1140
tttcgtggat tacaacaatt cattcacatt ttcaggctcc acttttaatt ctaattctat 1200
tgctgttttc accatatctg cagttacttc ctccactaaa ctcttatacc cttcaaggtc 1260
atccatgagg tttggaatca acttttttgg aactcctgtt gatgttgata ttttgacctc 1320
ttcccgtgag tcatgaatgt tctcaatggc atctatgatg gtgatttttt tctgaaggtt 1380
ttcaatttac tttgcccaga tgcatcagag gaatcactat ctatggctgc ttatattgcc 1440
ttacaaaata tatttctttt tttttttttt ttgagttgtt gtcttgctca gttacccagg 1500
ctggagtgca gtggcgtgat ctcggctcac tgcaagctcc gcctcccagg ttcatgccat 1560
tctcctgtct cagccttccg agtaactggg actacaggtg cccgccacca ggtccggcta 1620
attttttttt tgtattttta gtagagatgg ggtttcacca tgttagccgg gatggtctcg 1680
atctcctgac ctcgtgatcc acacgcctcg gctgggatta cagacacaaa atatatttct 1740
taataagact tgaaagtcaa acctattcct ggatccatgg gctgcagaat ggatattgaa 1800
ttagtaggca tgaaaacaac atggattttt ttgtacttct ccatcagaac tcttgtgtgg 1860
ccaggtgcat tgttaatgag cagtaacatt ttgacaggaa tctctttttc tgagcagtag 1920
gtctcaacag tgggcttaaa atattcagta aaccattctg taaatagatc tgctatcacc 1980
caggctttct tgttctattk tggagtgcaa gcagggagat ttagcatcat tcttaagggc 2040
cttgggtttt tggaatggaa catcagcact gattggcctc aacttagagt caccagctgc 2100
attagccact aacaagagag gcagcctgtc ctttgaagct ttgaagcctg ccattgactt 2160
ctccctagct aagaaagtgc tagatgacat cttcttccag taggaggctc tttcatctac 2220
attgaaaatc agttgtttag tgtagccatc ttcatcaatg atcttaacta tatcttctgg 2280
ataacttgct tcagcttctt catcagcact tgctccttca tcttgtactt ttacgttatg 2340
gagacaactt tccttaaacc tcatgaacca acgtttggta gcttccaact tcagcttcct 2400
cccctctctc agccttgata gaattgaaga gagttaaagc cttgttctgg attaggcttt 2460
ggcataggga atgtttcatt ccagaccact aaaactttct gcatctcagg gataaagttg 2520
tttcactttc tcatcattca catgttcatg gaagtagcgc ttttaacttc cttcaataac 2580
ttttcctttg catttgcaat tttgctaatt tttttgttgc aaaaggccta atttttagcc 2640
tgtcttggct ttccatgtgc ctttctcact aagcttgttt ctagcttttg atttaaaatg 2700
agagatgtgc gactattcct tttacttgaa cacttagagg ccattgcagg gttattaatt 2760
ggcctaattt caatattgtt gtgtctcaag taatgggctt ggtgaaaggg agagacagag 2820
aggaatggtt gtcagtggag cagtgagatc acacacactt ttaagtagct aagtttgctg 2880
tcttatatgg gtgtgattca tggtccccca aaatagttac aatagtaaca tcaaagatca 2940
ctgatcacgt caccaaaaca gatattataa taatgaggaa gtttgagata ttgtgagaat 3000
taccagaatg tggcacagag acaggaagtg agcacatgct gttggaaaaa tggcactgat 3060
agatttgctt aatgcaaggt tgccacaaag cttcaattgg caaaaaatgc aatacctgtg 3120
agtataatac aataaaatga ggtatgtcgg aacctgatta tgtcttagtc ataaaactta 3180
caaagaagta ggaggaatat tttccatgcc aacagaatgt atttaaatga tttgatatgt 3240
atttgaggt 3249
<210> 336
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 336
aagtgtgttt ccaccatacc ttgttggtcc aaaacacctc tccccagctc cagcaactgc 60
tgcagctgtg cagggcagtc cctctccagg taggccctgt tctgcctggc ccgaatcttg 120
tgcctttccc actccagctt ggtgggccag gccctgggtt ctgctgctct ccaatccagt 180
gtgtcagggc agaattcaag gtggtcctgc ccatcatacc cgtacttcca gtagccctcg 240
gtactgttgt cttcttgcat ttcacagccc aggatgacct gcagggtgtg ggactctgga 300
aaaatcccca gccttgttaa ctgcaaccaa aggaataggt ccctatttcc accatcccca 360
aggaccaaat gatctcagga agcaaattcc ttccctcttc cctgctccca caagacctca 420
gacttccagc tgtttccttc aagatgcatg aaaagatgaa aagctctgac aacctcagga 480
aggtgaggcc ccctctccac rtacccttgc tgtggttgtg attttccata atagtccaga 540
agtcaacagt gaacatgtga tcccaccctt tcagactctg actcagctgc agccacatct 600
ggcttgaaat tctactggaa acccatggag ttcggggctc cacacggcga ctctcatgat 660
catagaacac gaacagctgg tcatccacgt agcccaaagc ttcaaacaag gaaagaccaa 720
ggtcctgctc tgaggcaccc atgaagaggt agtgcagaga gtgtgaacct ggagacagag 780
caacaggcct taaccatgtg tagtaggagg ggagcaggat gttgaggctc cacacacctg 840
catcaactca taccatcagc tgtgtctggt cctcattttg tgaagggtga gttgcagtcc 900
tgtctttctt ccatatgaca gtcctgggtg ctctttcctt gtgtgctttt ctctgccaca 960
cgtggctgcc accccctcac tgcccccaga tcctattcca a 1001
<210> 337
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 337
cagagccacc ctagccattg gtataataga aataattatt attgccactc ttataaatta 60
ctgcaccagc cagtctacat caatcccaga tggagatatt actgaccctc ttcctccagg 120
tcacccagtt ggtaaatgaa agagatgata tttgttcaga agccagtttg acctgcaaaa 180
ttttgctttt aaacacctcg caagagtgcc tatttcttgg aattatcttc catagctgct 240
actgtctcca ctagctagtt tcaaagcata tggatgatca gatacaaagc ttcagcttcc 300
tgccacttct ccctcacttt tgtcagtctt gttaatatgg atttttacat ttttcatttt 360
tatttttatc atatgaggaa acttggggtt ggggagtata taaaaattgt ccattgctat 420
acagaaaaga gttttggagg tcttcatctc aataccaaga gaagtgactt accgacttaa 480
tgtctgtgga agggcttcaa rttgaaccca gcgtttcctc caagcttact cccttggact 540
ttttggagca gagagatgag gattctttgc caccctaggg cttaagttgc taatcattaa 600
taaaagtcat caaactacaa agttgactca gaagggcttc ttgccaaata ggctttgaag 660
aagcattcgg aaatccagcc caatcccctc tgcagttctt tctgcttttt ggctgatgta 720
agcttctcca ccttcccctt gtgagtgtct cctcaggacc tcataggtgt cctctggttc 780
agacacttgc atatagctat tttgctttgc tttgtggtgt cttcaatgtc tttagtcttt 840
tttgaaaagg ttaaaaagag ataaattata attaaagagt tcagtatttt tgtgtttttt 900
actttgctat ttttgatttt cccccttaat tgaaattttg ttaatttttt tcttctttga 960
aatatgtgaa ttgtaatatt atgggtaaac ttgaacttca t 1001
<210> 338
<211> 2131
<212> DNA
<213> Homo sapiens
<400> 338
aaaaagtatc agcaagttat gtttggatgc caaattgctc tccacttccc ttccctgaca 60
ctggcatttc cagaacttag atgctcttac atgtaaaagc ctcctctagt gcaccatcga 120
gcttttcagg attggacatc agacttttta gttcctggac ctctagatat acggcagtct 180
ctgacaagaa gccctttttc tgttttaact tttttttttt ttaagttttg agacaacgtc 240
tgactcgctg tcacccaggc tggagtgagg tagcaccatc atagctcact gtatccttaa 300
acgcctgggt gcagggacta agggagcgtg ccaaccatgc ttgactaatt tacttttttg 360
taaaaccagt agtctccaac ctttttgaca caagagaccg ttttgtgtaa gacaattata 420
ccacggacca gggggtgcag gggctgggag caatgatttc cggactaaaa ctgctccaac 480
ctcagatcat caggcattag attgtcacaa ggagcctgaa acctagatcc cttgcatgtg 540
ccattcacaa tacagtttga gcttatgaga atctatctaa tgctgcagct aacctgacag 600
gcggtggagc tcagttggtt aatgttcgct cacccctcag ctgtgcggct caattcataa 660
cgtgccatgg acagggaccg gttaccggtc ggtggccggg graatgagga cccctggtat 720
agatggtagt ctggctatgt tgcccaggat ggtcttgaag cctggcctga attaattctc 780
caatctcaag ccttttcaac tcagctgcat cacaacttaa acctatagat aactgtcaca 840
gaaacttgtt tccagtgtta cgccatctta aaataatgtg ggtggctctt aaaagagcct 900
ttgggttctt tccaaattgg cctcccggaa agctctttac ttcttagatg tggcctttct 960
aacattaact tcatgatgtt gggtcaattt tgacttcgaa gcccttgcct tcactgggct 1020
cttctgctgt tgcttaccct tggctccttt agcctttctc ccgctcctaa cagttttagg 1080
agttgtcgct ctcggcttct tggctctctt attggtttta gcagtctttg gtgacttgga 1140
gtccctggat aaaaccagct tcttggtctt ggcagaaact gactttttag ccttgcttct 1200
ggtagattta ggaatcacct tcttactaag cttaaaggaa ccggaagcac cagtacccct 1260
ggtttgcacc aggattccct tgttcactaa gctcttgagg gacagtttga tgcggctgtt 1320
attcttctct acgtcgtagc cagcagcggc caatgccttc ttgagcgcaa ccaaagacat 1380
acctactcgt tcctgtgaca ctgaaagggc ctcggtgatc aacttggaca cagagaggtt 1440
cggcactttg cgacttgcac ttatcaagcc agccggcttc ctccctcgct tcttggttgg 1500
aagtttctcc atagcggcta caccagcact ggcagaagct gcaggcacgg tttcagacat 1560
aacaacagag aaacgcaaga tgtaataacc agcgaaaagc atgaaacacc cgggcggcct 1620
cggggcctta tatagggtag ggcgcgctgt gattggtgca tcacctaggc accgcccccg 1680
ccccttggag gaggagtatt tgtgtttgtt ttacccggaa aagttgagta taacaaaacc 1740
cctctttaca gaatctccca gggtctagtg ctgaataatc tgcggaaatt catatttgac 1800
atgacttttc tctttttaat gaaaaatgac cctggatgcc aaaactattc gagaaagccc 1860
tcgattttca atcaaattca cggagaggaa caaaacttcc ccttttcctt gtaaattaat 1920
aagtaatctt tggcagaaga cttatttcat ctcttcagag tggtcttcca aatggatagc 1980
ttcaaatcgg tagaggaaag aaattattca cgccatgatt tttatttaaa attatttata 2040
tatgtgaggg aagtaacaca gatctcttag ctgtctaatt gcggagtcag aagatgctta 2100
tagaattgtc aaaagactgc agaggatgtc t 2131
<210> 339
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 339
tctctcagac ttttgcagaa aaatgagtca ttcaacaaat atttgaatcg agatagggaa 60
agtgacgagg aagaagtttg cacttatgag gttttaattt gcaattattt ggctaccttt 120
ttgccttccc aaaacatagg gtctttagga gtgaaacttc atagccaaac ttataccttg 180
tccagcacag agaaggccat caaaatgcct ggtttaaata aaaatattaa aatgattggg 240
agggtaaatc ccttgaccta taaatctgac ctcctttaaa cattatttgt atgttcccca 300
ataaactatt ccgtaattta ttagttagca agtggaaata aaaagaaatg tggaatgggg 360
ctatgcttag cgtcattaag ctgacaggaa tacagcgcat tcaacttgca aacacccttc 420
cactcccaca aagagcaagc tgtcactggc caatcaaaac aatgaaccat aatgaaacag 480
tttttcttgc tccacccact yggtgaccaa atttgaaaaa aaaaaaaaac cgcgccaact 540
catgttgttt tcaatcaggt ccgccaagtt tgtatttaag gaactgtttc agttcatacc 600
ttccactgcg ataggaatca tgtctggtcg cggcaaaggc ggaaaaggct tggggaaggg 660
tggtgctaag cgccatcgta aggtgctccg ggataacatc cagggcatta caaaaccggc 720
tattcgccgt ttggctcggc gcggtggcgt caagcgcatt tccggtctta tctatgagga 780
gactcgaggt gtgcttaagg ttttcttaga gaacgttatt cgagacgccg tcacctatac 840
ggagcacgcc aagcgcaaaa ctgtcacagc catggatgta gtatatgccc taaaacgtca 900
ggggcgcact ctgtatggct tcggcggctg aatctaagaa tacgcggtct cctgagaact 960
tcaaaaaaca aaaacaaaaa aacccaaagg cccttttcag g 1001
<210> 340
<211> 1001
<212> DNA
<213> Homo sapiens
<400> 340
aatcattttt ttataacaac aaaggcattt gcactgagag tcaaggaagt accgaattat 60
tcctgttttt actgaattgt attaaaatat aaggaggata taataggaaa acacagcatg 120
tgttcatcaa tcacttctcc tgagtctcct cacttggtca aaaatttccg gagaaatttt 180
tgtttgtacc tgatttgaaa agaaaaacaa gggagcggtt ggaggggaag ggtggagaga 240
tgaggggagg gagtgcccta gtggaaacca cagcattaac accacctact acttctactt 300
cactaaaggc actgtcccga ttttttcttc agagatcact gttttgcctg ctgaattcaa 360
acctccaccc cagacacact gatgtcattg gaggcatcag gactgggggc ccaagtttta 420
ttatattaaa acgagttcat gctggggtaa attttaagat ctttagtgga cagaaaggca 480
gttcaaattc tttgatttta rtgacaaaat gctttaaact gacaatgcaa cctatcaaca 540
aaaggaccat attgagctgt gtgtgggctg cacagaaata cgccgcccca gaactctaag 600
tgctcccgga aaagctcgca attgttacaa cagagaatcc aattcttgtg gctaaagtat 660
ctcctggggg acttattaca aatgtggatt ctagaacccc tcgtgcaatg atcctgacta 720
aagcgattta ctatgggtcc caagaatctt aatcttacca agcaccctca agtaattcta 780
acttcaatag tctgctaaac ggcactcagt gaagggtgct aaagctgtca tggggaattt 840
aaaaactcat gaaataagct cgtagaaagg aagtttaggg tctggaggac acagagctga 900
aatgaaatcc tgaagtaggg ttggaatata attaatttat gtaacaatac tgaacaccta 960
gtgtgtggcg tgcccctttg tttttcaggt aatcagagga a 1001
<210> 341
<211> 520
<212> DNA
<213> Homo sapiens
<400> 341
ccttgaagct acggaattac aattctcctt cacaaagaca gtcaaaggat gtgatctgat 60
gtgttagatt ttctctctcc tgttcaatat ggagttttgc atcttagttt ctttgggccg 120
ctataagaaa atacactaaa ctaggtgact aacaaataac aggattttac ttcttacagt 180
tctaaaggct aggaagtcta agatcaagga gacaccatat tctatgtcta atgaggctca 240
ctctctgctt catagatagc atcttcttgc tgcaacttcg tayggtacag ggggtgaaca 300
agctccctct tttatagggg tactaatccc attcatgagg acgccatcct tatgacctat 360
tcacctccca aaggccccac ctcttaatac caccataatg gggattatgc ttcaacacaa 420
gtatttgttt cttgtttttg ttttcaacat aaatatttgg agggtaacca ttcagatcat 480
agtagtacca gtatccaaaa ctgccaccaa atagtttgtt 520
Claims (1)
- 대상체에서 염증성 장 질환(IBD: inflammatory bowel disease) 발병의 저확률 또는 고확률을 예측하는 방법으로서,
유전자/유전자좌에서 위험 대립유전자에 대해 대상체의 유전자형을 분석하는 단계; 및
위험 대립유전자가 검출될 때, 대상체에서 IBD 발병의 고확률을 예측하거나; 또는 위험 대립유전자가 검출되지 않을 때, 대상체에서 IBD 발병의 저확률을 예측하는 단계
를 포함하는 방법.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| US201662339357P | 2016-05-20 | 2016-05-20 | |
| US62/339,357 | 2016-05-20 | ||
| PCT/US2017/033625 WO2017201461A1 (en) | 2016-05-20 | 2017-05-19 | Diagnosis of inflammatory bowel disease based on genes |
| KR1020227044940A KR20230003433A (ko) | 2016-05-20 | 2017-05-19 | 유전자에 기반한 염증성 장 질환의 진단 |
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| KR1020227044940A Division KR20230003433A (ko) | 2016-05-20 | 2017-05-19 | 유전자에 기반한 염증성 장 질환의 진단 |
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| KR1020247019512A KR20240095363A (ko) | 2016-05-20 | 2017-05-19 | 유전자에 기반한 염증성 장 질환의 진단 |
| KR1020227003985A KR102481305B1 (ko) | 2016-05-20 | 2017-05-19 | 유전자에 기반한 염증성 장 질환의 진단 |
| KR1020187037151A KR20190016972A (ko) | 2016-05-20 | 2017-05-19 | 유전자에 기반한 염증성 장 질환의 진단 |
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| KR1020187037151A KR20190016972A (ko) | 2016-05-20 | 2017-05-19 | 유전자에 기반한 염증성 장 질환의 진단 |
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| EP (1) | EP3458466B1 (ko) |
| JP (3) | JP7475811B2 (ko) |
| KR (4) | KR20230003433A (ko) |
| CN (2) | CN117286238A (ko) |
| WO (1) | WO2017201461A1 (ko) |
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| BR112021022789A2 (pt) | 2019-05-14 | 2022-04-19 | Cedars Sinai Medical Center | Métodos, sistemas e dispositivos para a seleção de pacientes para tl1a |
| JP2022022994A (ja) * | 2020-06-26 | 2022-02-07 | ファイザー・インク | Ｔｌ１ａ抗体で炎症性腸疾患を処置する方法 |
| WO2024148218A2 (en) * | 2023-01-06 | 2024-07-11 | Prometheus Biosciences, Inc. | Methods of treating inflammatory diseases with combination of tl1a inhibitors and tnf inhibitors |
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| US20230366028A1 (en) | 2023-11-16 |
| EP3458466B1 (en) | 2024-08-07 |
| CN109476698B (zh) | 2023-10-17 |
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| JP2024037945A (ja) | 2024-03-19 |
| JP2022095688A (ja) | 2022-06-28 |
| WO2017201461A1 (en) | 2017-11-23 |
| KR20190016972A (ko) | 2019-02-19 |
| JP2019516375A (ja) | 2019-06-20 |
| EP3458466A4 (en) | 2020-03-04 |
| JP7475811B2 (ja) | 2024-04-30 |
| US20190194754A1 (en) | 2019-06-27 |
| EP3458466A1 (en) | 2019-03-27 |
| JP7392020B2 (ja) | 2023-12-05 |
| KR20220025122A (ko) | 2022-03-03 |
| CN117286238A (zh) | 2023-12-26 |
| KR20230003433A (ko) | 2023-01-05 |
| US11549146B2 (en) | 2023-01-10 |
| CN109476698A (zh) | 2019-03-15 |
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