KR20210111230A - Antibacterial or conservative composition containing polyglycerine-3 - Google Patents

Abstract

The present invention relates to an antibacterial or preserving composition which contains polyglycerin-3 as a preserving agent. An antibacterial or preserving composition according to the present invention has excellent resistance against microorganisms by containing polyglycerin-3, has no skin side effect, and has excellent skin moisturizing power.

Description

Antibacterial or preservative composition containing polyglycerin-3 {ANTIBACTERIAL OR CONSERVATIVE COMPOSITION CONTAINING POLYGLYCERINE-3}

The present invention relates to an antibacterial or preservation composition containing a specific glycerin derivative and having excellent antibacterial and antiseptic properties.

Various products such as cosmetics and human body products contain various materials such as moisturizing agents, oils, surfactants, inorganic powders, organic water-soluble polymers, and fragrances, which are suitable for the growth of microorganisms. Therefore, it is common to add a chemical preservative to prevent the product from decaying by microorganisms and to prevent deterioration of the product by killing the microorganisms over time. As such chemical preservatives, parabens, imidazolidinyl urea, phenoxy ethanol, paraoxybenzoic acid esters, or benzalkonium chloride are generally used.

However, as new additives such as proteins, gums, vitamins, and medicinal plants are added to products in recent years, the changes caused by the action of microorganisms are diversified, and the oriental medicinal side effect of chemical preservatives is weakened, and the content of chemical preservatives is increasing. As the content of chemical preservatives increases, the problem of harm to the body, such as irritation to the skin, allergic symptoms, etc., is emerging.

Accordingly, there is a demand for new products that do not contain chemical preservatives or are not spoiled by microorganisms even if they contain a small amount.

The present invention not only has excellent antibacterial and antiseptic properties, but also can achieve a moisturizing effect without stickiness, even when chemical preservatives are not used or a small amount is used. An object of the present invention is to provide an antibacterial or preservative composition without skin side effects.

The present invention provides an antibacterial or preservative composition comprising a compound of Formula 1 below.

[Formula 1]

In order to solve the problems of the prior art, the present inventors tested various components, and among these components, polyglycerin-3 of Formula 1 was able to achieve antibacterial and antiseptic effects.

As a result, by using polyglycerin-3, chemical preservatives could not be used or its content could be reduced, and skin side effects did not occur. did it

The antibacterial or preservative composition according to the present invention contains polyglycerin-3, so that it has excellent resistance to microorganisms even if it does not use or uses a small amount of chemical preservatives, has excellent moisturizing power, and does not cause skin side effects.

The present invention relates to an antibacterial or preservative composition comprising polyglycerin-3 represented by the following formula (1).

[Formula 1]

Hereinafter, the antibacterial or preservative composition according to the present invention will be described in more detail.

As used herein, the term “antibacterial” refers to the ability to resist bacteria, and refers to all mechanisms made to defend against the action of microorganisms such as bacteria or fungi.

As used herein, the term "bacteria" refers to an organism belonging to bacteria, the most prosperous species among living organisms, and is mostly pathogenic and has the characteristics of prokaryotes as it is, but does not have structures such as nuclear membranes, mitochondria, and chloroplasts. The size varies from 0.5 μm to 0.5 mm. As the bacterium, for example, Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15522, and Escherichia coli ATCC10536 can be used.

As used herein, the term "fungi" refers to a group of microorganisms composed of more than 72,000 species including mold, yeast, and mushrooms, belongs to eukaryotes with a nuclear membrane, and organelles such as mitochondria and endoplasmic reticulum are developed, It has a cell wall composed of chitin and glucan. Most of them form cellular hyphae, elongate and develop, and are characterized by sexual and asexual reproduction. They form spores as propagules, but some species reproduce unicellularly. It is mainly involved in organic decomposition in nature as saprophytes, but some are parasitic or symbiotic with animals and plants. The fungi may be, for example, Aspergillus niger (Aspergillus niger ATCC 9642) and Candida albicans (Candida albicans ATCC 10231).

In the present invention, polyglycerin-3 is used as a preservative, and can exhibit excellent antibacterial and antiseptic effects.

The content of the polyglycerin-3 may be 0.01 to 40% by weight or 1 to 10% by weight based on the total weight of the total composition. Antibacterial and preservative effects are excellent in the above content range. If the content of the polyglycerin-3 is less than 0.01% by weight, it does not greatly help the antibacterial and antiseptic effects, and if it exceeds 40% by weight, it may cause a problem that the feeling is sticky.

The antibacterial or preservative composition of the present invention may further include a chemical preservative in addition to polyglycerin-3.

Polyglycerin-3 can be used together with chemical preservatives to create a synergistic effect, resulting in greater antibacterial and antiseptic effects. Specifically, since the polyglycerin-3 exhibits excellent antibacterial and antiseptic effects, it can exhibit excellent antibacterial and antiseptic effects even with a small amount of chemical preservatives. Therefore, unlike conventional cosmetic compositions using an excessive amount of chemical preservatives cause skin side effects such as skin irritation and allergies, the antibacterial or preservative composition of the present invention hardly causes skin side effects such as skin irritation and allergies.

Examples of the chemical preservative include polyols such as 3-hexyloxy-1,2-propanediol, 1,2-hexanediol, and octanediol, parabens such as methylparaben, ethylparaben or propylparaben; and one selected from the group consisting of phenoxyethanol and the like, or a mixture of two or more may be used.

The content of the chemical preservative may be 0.01 to 30% by weight, 0.1 to 10% by weight, or 0.5 to 5% by weight based on the total weight of the composition. In the above range, the synergistic effect with polyglycerin-3 is excellent, and when it exceeds 30% by weight, there is a risk of skin side effects such as skin irritation and allergies.

As described above, the present invention provides an antibacterial or preservative composition containing polyglycerin-3 of Chemical Formula 1 having excellent antibacterial and antiseptic properties. Such an antibacterial or preservative composition may be used for purposes such as cosmetics, quasi-drugs, pharmaceuticals or preservatives.

In one aspect, the present invention may provide a cosmetic composition comprising the antibacterial or preservative composition according to the present invention. In the present invention, since the cosmetic composition contains polyglycerin-3, it is possible to improve stability as well as antibacterial activity.

Polyglycerin-3 contained as an active ingredient is a colorless and transparent liquid, and has excellent solubilization ability and emulsion stabilization ability compared to conventional moisturizers, so it is very advantageous for the stability of the cosmetic composition. However, the composition stabilization effect of polyglycerin-3 of the present invention is not limited to the above theoretical assumption. Therefore, polyglycerin-3 according to the present invention is an oil-in-water or water-in-oil cosmetic composition, emulsion, micro-emulsion, skin, lotion, cream, foundation, essence, gel, pack, foam cleanser, softening lotion, astringent lotion, mascara, eye It can be used to improve the stability of various formulations such as liners, shampoos, conditioners, soaps, body cleansers, hair dressings, and hair products, but the present invention is not limited to these formulations.

The present invention provides a method for improving the stability of a cosmetic composition, characterized in that the addition of polyglycerin-3 to the cosmetic composition. The polyglycerin-3 may be used as a moisturizer.

Preferably, the present invention is characterized in that it contains 1-60% by weight of an aqueous phase component, 1-10% by weight of a humectant, 0.1-5% by weight of a surfactant, 0.1-30% by weight of an oil, and the remaining amount of water with respect to the total weight of the composition It provides a cosmetic composition of oil-in-water and water-in-oil type.

In the cosmetic composition with improved stability according to the present invention, the humectants include propylene glycol, 1,3-butylene glycol, and dipropylene glycol within the range that does not impair the purpose of the present invention other than polyglycerin-3 according to the present invention. , glycols such as polyethylene glycol; Glycerol, such as glycerol and diglycerol; sugars such as sorbitol, multitol, sucrose, starch sugar, and racucitol; hyaluronic acid; Water-soluble components such as betaine may be additionally used, but for the purpose of the present invention, the moisturizing agent is preferably polyglycerin-3 of Formula 1 above. These moisturizers increase the moisturizing ability of the skin and lower the polarity of the aqueous phase, so waxes, higher alcohols, surfactants, etc. with low polarity interact with the aqueous phase to help form a stable emulsion.

The cosmetic composition with improved stability of the present invention may further contain higher alcohols, waxes, flavoring agents, coloring agents, etc. within a range that does not impair the purpose of the present invention, which are conventional in the art to which the present invention pertains. You can choose to use it.

As another aspect, the present invention may provide a quasi-drug composition comprising the antibacterial or preservative composition according to the present invention. That is, the composition of the present invention may be added to a quasi-drug composition requiring antibacterial or preservation.

When the composition of the present invention is used as an additive, the composition may be added as it is or used together with other quasi-drugs or quasi-drug components, and may be appropriately used according to a conventional method. The mixing amount of the active ingredient may be appropriately determined according to the purpose of use.

The quasi-drug composition may be, for example, disinfectant cleaner, shower foam, gargrin, wet tissue, detergent soap, hand wash, humidifier filler, mask, ointment, coating agent or filter filler.

As another aspect, the present invention may provide a pharmaceutical composition comprising the antibacterial or preservative composition according to the present invention.

The pharmaceutical composition of the present invention can be formulated and used in the form of tablets, pills, powders, granules, capsules, suspensions, internal solutions, emulsions or syrups according to conventional methods, oral dosage forms, external preparations, suppositories, or injection solutions. have. Specifically, when formulating, it may be prepared using a diluent or excipient such as a filler, a weight agent, a binder, a wetting agent, a disintegrant, and a surfactant commonly used. Solid preparations for oral administration include, but are not limited to, tablets, pills, powders, granules, capsules, and the like. Such a solid preparation may be prepared by mixing at least one or more excipients, for example, starch, calcium carbonate, sucrose, lactose, gelatin, etc. in addition to polyglycerin-3 of Formula 1 above.

In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. It can be prepared by adding various excipients, for example, wetting agents, sweetening agents, fragrances, preservatives, and the like, in addition to liquid water and liquid paraffin for oral use. Formulations for parenteral administration may include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations and suppositories. As the non-aqueous solvent and suspending agent, propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate may be used. As the base of the suppository, Witepsol, Macrogol, Tween 61, cacao butter, laurin, glycerogelatin, etc. may be used.

The composition of the present invention may be administered orally or parenterally (eg, intravenously, subcutaneously, intraperitoneally or topically) according to a desired method, and the dosage may vary depending on the condition and weight of the patient, the degree of disease, Although it varies depending on the drug form, administration route and time, it may be appropriately selected by those skilled in the art.

As another aspect, the present invention may provide a preservative composition comprising the antibacterial or preservative composition according to the present invention.

The preservative composition may be used by mixing an appropriate amount of commonly used ingredients according to the type and purpose of use of the product containing the preservative composition. For example, acetic acid, sodium acetate-based, sorbic acid-based, benzoic acid-based, propionic acid-based can be added, and natural linseed oil soap, propolis soap, acacia sap, etc. are emulsified with natural emulsifiers to manufacture liquid, It can be freely manufactured and supplied, such as powder.

Hereinafter, the present invention will be described in detail by way of Examples. However, the following examples are merely illustrative of the present invention, and the content of the present invention is not limited to the following examples.

Reference Example 1: Polyglycerin-3 material information

[Formula 1]

Compound name: polyglycerin-3;

3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]propane-1,2-diol

CAS No.: 56090-54-1

<Comparative Examples and Examples 1-4>

An emulsion-type antibacterial or preservative cosmetic composition was prepared in a conventional manner using the composition components and contents shown in Table 1 below.

Ingredient name Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Polyglycerin-3 - 2,000 2.000 4.000 6.000 Purified water To 100 To 100 To 100 To 100 To 100 glycerin 4.000 4.000 4.000 4.000 4.000 1,2-Hexanediol 0.500 - 0.500 0.500 0.500 panthenol 0.500 0.500 0.500 0.500 0.500 Trisodium EDIT 0.002 0.002 0.002 0.002 0.002 wax 0.500 0.500 0.500 0.500 0.500 PEG-40 Hydrogenated Castor Oil 0.300 0.300 0.300 0.300 0.300 xanthan gum 0.030 0.030 0.030 0.030 0.030 incense Q.S. Q.S. Q.S. Q.S. Q.S. methylparaben 0.200 - - - - ethylparaben 0.100 - - - - Propylparaben 0.100 - - - -

<Experimental Example 1> In order to test the antibacterial and antiseptic effects of the compositions of Comparative Examples 1 and 1 to 4, bacteria or fungi were added to the sample and the change in the number of inoculum was checked, and the number of fungi or bacteria was 20 CFU The days starting to become less than /g were recorded and shown in Table 2 below. Measurements were made up to 28 days, and the detailed test process is as follows.

First, after each 40 g of the cosmetic composition was put in, bacteria, that is, Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15522, Escherichia coli ATCC10536) etc. were added to the sample so as to have the number of 106 per 1 g of the sample, mixed, and stored for 4 weeks. Then, each time 1, 7, 14, 21, and 28 days elapsed from the day of inoculation, the change in the number of inoculated bacteria was checked.

The test process using fungi is the same as the test process using bacteria, and Aspergillus niger (ATCC 9642) and Candida albicans (Candida albicans ATCC 10231) were used as fungi.

Evaluation items
comparative example Example One One 2 3 4 Germ 14 days 14 days 7 days 3 days 1 day fungus 14 days 14 days 7 days 3 days 1 day

As shown in Table 2 above, in the case of the comparative example, the number of fungi or bacteria of 20 CFU/g or less from the 14th day using a chemical preservative showed antibacterial and antiseptic effects. On the other hand, Example 1 of the present invention Although no preservative was used, the number of fungi or bacteria of 20 CFU/g or less from the 14th day was shown, indicating that there was an antibacterial and antiseptic effect similar to that of Comparative Example 1 using a chemical preservative. In particular, in the case of Examples 3 and 4 containing 4% by weight or more of polyglycerin-3, the number of fungi and bacteria was rapidly reduced, and the number of fungi or bacteria of 20 CFU/g or less from the 3rd day and the 1st day, respectively, was obtained. It exhibited a much superior antibacterial and antiseptic effect than the comparative example containing a chemical preservative, which can be seen to exhibit a very excellent antibacterial and antiseptic effect due to the synergistic effect of polyglycerin-3 and 1,2-hexanediol.

<Test Example 2>

In order to evaluate the skin irritation of Example 4 and Comparative Example 1, a primary irritation test was performed on the human body through a human patchtest in the following manner.

The stimulation test was conducted on 50 healthy adult males according to the CTFA guidelines [Reference: The Cosmetic, Toility and Fragrance Association. Inc. Washington, D.C., 20036.19941]. After dropping 15 mL of the sample and solution into the Finn Chamber, it was placed on the back of the human body, the test site, and fixed with tape. Then, after applying the patch for 24 hours, the patch was removed and 4 hours passed. Then, the skin reaction of the test site was judged according to the following criteria, and the results are shown in Table 3 below.

<Criteria for Judgment>

- : No erythema or unusual phenomenon

+/- : Slightly redder than the surrounding area

+ : Significantly redder than the surrounding area

++ : Redness and swelling worse than the surrounding area

Stimulus = [{(+/-) number x 1} + {(+) number x 2} + {(++) number x 3}]/number of subjects

sample number of subjects Judgment result stimulus degree ++ + +/- - Example 4 50 0 0 3 47 0.06 Comparative Example 1 50 0 3 4 43 0.20

As shown in Table 3, in the case of Example 4 using polyglycerin-3, it can be confirmed that skin irritation was significantly reduced compared to Comparative Example 1 using a chemical preservative.

Claims (6)

A cosmetic composition comprising polyglycerin-3 of Formula 1 below, and not containing a chemical preservative.

[Formula 1]

The method of claim 1,
The chemical preservative is at least one cosmetic composition selected from the group consisting of methylparaben, ethylparaben and propylparaben.
The method of claim 1,
Polyglycerin-3 is a cosmetic composition comprising 0.01 to 40% by weight based on the total weight of the composition.
It contains polyglycerin-3 and polyol of Formula 1,
A cosmetic composition that does not contain one or more chemical preservatives selected from the group consisting of methylparaben, ethylparaben and propylparaben.

[Formula 1]

5. The method of claim 4,
The polyol is at least one selected from the group consisting of 3-hexyloxy-1,2-propanediol, 1,2-hexanediol and octanediol.
The method of claim 1,
Polyglycerin-3 is a cosmetic composition comprising 0.01 to 40% by weight based on the total weight of the composition.