KR20210048921A - Method for training electric opepration using biomimetic strucure and biomimetic strucure and compostion for the same - Google Patents

Abstract

The present invention relates to a surgical training method based on a biomimetic structure and the biomimetic structure and compositions for the same, wherein the biomimetic structure has electrical conductivity, mechanical strength and elasticity, and includes a channel in which a vascular mimetic fluid is accommodated. According to the present invention, as an incision of a skin like a living body, suturing of blood vessels, and incision are performed in the transparent biomimetic structure, so unlike Cadevana and non-conductive silicone-based structure, very realistic surgical training can be performed.

Description

[Method for training electric opepration using biomimetic strucure and biomimetic strucure and compostion for the same}

The present invention relates to a surgical training method using a biomimetic structure, a biomimetic structure and a composition therefor, and more particularly, a structure that exhibits phenomena such as evaporation, incision, and suture on an electrical surgical tool such as an electric cauterizer. , It relates to a surgical training method using a biomimetic structure that can improve the surgical ability of the actual medical staff, a biomimetic structure and a composition therefor.

Surgeons and residents often use animal models such as pigs or use cadavers to educate and train in order to improve their technical expertise prior to direct surgery on patients.

In general, an animal model and a catheter are used to administer surgery instructions for medical staff, and in particular, education and skill development of laparoscopic surgery and further robotic surgery have been actively conducted through this.

However, the limitations of using an animal model or a cadava as a textbook for medical staff surgery instructions are often pointed out. It is difficult to obtain corpses for cadava worldwide because it is difficult to donate corpses for cadava. In some regions, cultural and religious use of cadava is prohibited, making it difficult to spread as a universal model.

In the case of animal models, as the spirit of respect for life of animal protection organizations is spreading, the use of animals is increasingly criticized and opposition is increasing. It may be restricted in use. Against this background, there is a need for a surgical education model that can replace animals or cadets.

Recognizing this demand, there are companies that have developed surgical simulators using artificial cadavers. SynDaver of the United States, Fasotec of Japan, and SINI of Korea are representative companies. Existing artificial cadavers developed to date are based on silicone materials. In the case of silicone material, it is possible to secure mechanical properties such as elasticity, touch, and texture similar to human tissues, and it is used as a representative surgical simulator material as it has the advantage of being able to mold, a method of easily manufacturing various human organ structures. do. However, since silicon materials do not conduct electricity, they cannot be applied to surgical training using an actual electrocautery, so unlike animal models or cadavers, they have a big disadvantage in that they are less realistic. In addition, there is a problem that surgery education and training such as blood vessel ligation and bleeding control using electric cautery, which are used in actual surgery, are impossible because restoration to the original state is impossible after amputation.

Furthermore, there is a problem in that phenomena such as evaporation and incision occur according to temperature conditions, and it is very difficult in reality to simulate a complex human body structure including vascular nerves with a material such as silicon.

Accordingly, the problem to be solved by the present invention is to provide a new method of surgical training using a biomimetic structure, and a structure and a composition therefor.

The present invention is an electrosurgery training method using a biomimetic structure, comprising the steps of: contacting an electrocautery machine to make an incision with a biomimetic structure having electrical conductivity, mechanical strength and elasticity, and having a channel in which a vascular mimic solution is accommodated; It characterized in that it comprises the step of observing the behavior of the blood vessel simulation solution in the channel during the incision.

The behavior of the blood vessel simulation solution may be a biomimetic structure characterized in that coagulation or bleeding, and the channel may be formed of a separate tube.

In addition, in the biomimetic structure, evaporation, incision, and blockage of the channel may occur in the biomimetic structure by varying the electric energy application method of the electric cautery machine.

Meanwhile, the biomimetic structure may be a hydrogel-based structure.

In addition, the present invention is a biomimetic structure for electrosurgical training, wherein the structure includes a material having electrical conductivity, and the material contains moisture so that evaporation or incision occurs according to the contact of the electric cauterizer. do.

The structure evaporates at a predetermined specific temperature or higher according to the electric energy applied to the electric cautery machine, and can be physically cut in a preset temperature range, and a blood vessel simulation solution accommodated in the biomimetic structure for surgical training A channel or a neuro-simulation channel may be provided.

In addition, there may be a plurality of blood vessel simulation channels, and a blood simulation solution of a different color may be accommodated in the plurality of channels.

Furthermore, the present invention is a material for a biomimetic structure for electrosurgery training, comprising: gelatin; And carrageenan, characterized in that it has mechanical stiffness and conductivity through pi-pi bonding between the gelatin and carrageenan.

According to the present invention, by using a biomimetic structure including a tube channel that simulates blood vessels and has conductivity to enable incision according to contact (including proximity access) to the electric cauterizer, the surgeon can actually use the electric cauterizer. It makes it possible to practice the surgery through very realistically. Therefore, 1) it can replace animal models and cadavers that are becoming increasingly difficult to supply and demand, 2) professional management institutions and procedures required when using animal models and cadavers become unnecessary, and 3) mass production becomes possible and education The cost can be reduced, and high-quality educational materials can be stably supplied and universalized, thereby contributing to the treatment of patients by improving the surgical ability of surgeons in the clinical field.

1 is a step diagram of a surgical training method using a biomimetic structure according to an embodiment of the present invention.
FIG. 2A is a diagram illustrating a method of manufacturing a biopsy material according to an embodiment of the present invention, and FIG. 2B is a result of comparing the elastic modulus when chemical treatment is performed according to an embodiment of the present invention.
3 is an experiment result of an electric cautery machine according to an embodiment of the present invention.
4 is a photograph showing a conductive hydrogel having various colors according to an embodiment of the present invention.
5 is a photograph of an artificial nose and an artificial ear manufactured by 3D printing using a material manufactured according to an embodiment of the present invention.

In order to solve the above problems, the present invention provides a surgical training method based on a biomimetic structure that has electrical conductivity, mechanical strength, and elasticity, and has a channel in which a blood vessel mimic solution is accommodated. As a result, since the incision of the skin, the suturing of blood vessels, and incisions are performed in a transparent biomimetic structure, as in an actual living body, a very realistic surgical training can be performed unlike Cadevar or non-conductive silicone-based herbicide. Therefore, 1) it can replace animal models and cadavers that are becoming increasingly difficult to supply and demand, 2) professional management institutions and procedures required when using animal models and cadavers become unnecessary, and 3) mass production becomes possible and education The cost can be reduced, high-quality educational materials can be stably supplied and universalized, thereby improving the surgical ability of surgeons in the clinical field, contributing to the treatment of patients.

1 is a step diagram of a surgical training method using a biomimetic structure according to an embodiment of the present invention.

Referring to FIG. 1, the surgical training method according to the present invention comprises the steps of making an incision by contacting a biomimetic structure having an electrical conductivity, mechanical strength and elasticity, and having a channel in which a blood vessel simulation solution is accommodated; And observing whether or not the blood vessel replicating solution from the channel comes out of the channel during the incision.

In particular, the surgical training method according to the present invention makes the biomimetic structure having mechanical strength and elasticity transparent so that the behavior of the vascular mimetic solution can be observed with the naked eye, whereby the surgeon can use the technique of suturing blood vessels or avoiding blood vessels. Allows them to train.

In one embodiment of the present invention, the channel is made of a separate tube, and in one embodiment of the present invention, the tube and the biomimetic structure are made of a material having conductivity and mechanical rigidity, whereby As the electrical energy application method is varied, evaporation, incision, and channel blockage of the biomimetic structure occur in the structure.

In one embodiment of the present invention, the biomimetic structure is based on a hydrogel to maintain the shape of the reaction between the hydrogel and the additive (carrageenan) for a long time. In other words, the present invention is a biomimetic structure based on a material that 1) has higher strength than existing materials, has durability that is easy to store for a long time, and can manufacture even artificial blood vessels in the form of a hollow tube capable of squirting and sealing blood. Can provide.

The material according to the present invention can be cut, ejected, blood vessel sealing, vaporization, desiccation, coagulation, and fulgulation according to the contact of the electric cauterizer and its energy.

FIG. 2A is a diagram illustrating a method of manufacturing a biopsy material according to an exemplary embodiment of the present invention, and FIG. 2B is a result of comparing an elastic modulus when a chemical treatment is performed according to an exemplary embodiment of the present invention.

2A and 2B, the biomimetic preparation according to an embodiment of the present invention may maintain mechanical rigidity through a hydrophobic bond (pi-pi bond) between gelatin and carrageenan. This indicates that it has conductivity that can be applied to an electric cautery machine commonly used in a circle, and it is easy to control stiffness according to the blending of materials, so that it can be manufactured to have mechanical properties similar to human tissue.

The present invention will be described in more detail through the following examples and experimental examples. However, the scope of the present invention is not limited to the following Examples and Experimental Examples.

Example

Manufacture of conductive hydrogel and structure

First, in 70 g Di-water, 0.3 g additive including 30 g gelatin and carrageenan was added and reacted at 80° C. for 30 minutes. After that, the lumped solution was well dispersed using a Vortex Mixer. After that, the pretreated 0.1, 0.2, or 0.3 g of micro nanofibers are mixed with the dispersed solution. The mechanical stiffness according to the target site can also be controlled according to the ratio between gelatin and carrageenan.

1 wt% of Propionic acid, Sorbic acid, or Benzoic acid was added to the mixed solution. After that, the mixed solution was removed from air bubbles at 60 °C.

Then, using the prepared material, a biomimetic structure was manufactured by 3D printing.

Vascular simulation channel manufacturing

An artificial blood vessel was fabricated by introducing the prepared conductive material and a sacrificial layer material that can be easily removed into a printing module in which a co-axial nozzle is inserted. The solution of the two phases is printed in a hollow tube and discharged due to laminar flow. Thereafter, the material of the sacrificial layer inserted into the artificial blood vessel was removed at a specific temperature. According to the type of co-axial printing head and the printing speed ratio between materials, blood vessels of various sizes such as 500, 1000, and 1500 um inner diameter were produced in various lengths.

Experimental Example 1

It was tested whether the artificial tissue of the biomimetic structure prepared in the above example could be used as an artificial catheter capable of electric cauterization and cutting using an electric cauterization machine for surgery.

3 is an experiment result of an electric cautery machine according to an embodiment of the present invention.

3, in the case of pork tissue, it can be seen that the tissue is cauterized by the operation of the electric cauterization machine (left image), but in the case of silicon, since it is a non-conductor, it did not react by the electric cauterization machine (center image), In the case of the conductive hydrogel developed according to the present invention, it can be confirmed that it is cauterized by reacting under the same operating conditions of the electric cauterization machine as the pork tissue (right image).

Experimental Example 2

By mixing a dye with the biomimetic herbicide prepared according to an embodiment of the present invention, organs can be clearly distinguished with the naked eye.FIG. 4 shows a conductive hydrogel having various colors according to an embodiment of the present invention. This is a picture showing.

Referring to FIG. 4, it is possible to display a color-colored hedgogen-based tube in which blood vessels, nerves, etc. can be clearly seen in a biomimetic structure having a level of transparency that can be observed with the naked eye, as blood vessels and nerves. A blood vessel replica having a color is put inside, so that it is possible to visually observe sutures and eruptions according to surgical training, and it is also possible to check whether only the desired blood vessels are well closed according to the color of the blood vessel replica.

Therefore, the material of the present invention can easily produce various artificial tissues using molding and 3D printing, and can provide a surgical artificial organ capable of ejecting and suturing blood, which was not possible in a simulator. Can provide surgical training model

Experimental Example 3

5 is a photograph of an artificial nose and an artificial ear manufactured by 3D printing using a material manufactured according to an embodiment of the present invention.

Referring to Figure 5, it can be seen that the material according to the present invention can very accurately simulate a complex body.

Claims (10)

As an electrosurgery training method using a biomimetic structure
Making an incision by contacting a biomimetic structure having an electrical conductivity, mechanical strength and elasticity, and having a channel in which a blood vessel simulation solution is accommodated;
Electrosurgery training method using a biomimetic structure, comprising the step of observing the behavior of the blood vessel simulation solution in the channel during the incision.
The method of claim 1,
Electrosurgery training method using a biomimetic structure, characterized in that the behavior of the blood vessel replica is coagulation or bleeding.
The method of claim 1,
Electrosurgery training method using a biomimetic structure, characterized in that the channel is made of a separate tube.
The method of claim 1,
The biomimetic structure is an electrosurgery training method using a biomimetic structure, characterized in that evaporation of the biomimetic structure, incision, and blockage of a channel occur as the method of applying electrical energy of the electric cauterizer is varied.
The method of claim 1,
The biomimetic structure is an electrosurgery training method using a biomimetic structure, characterized in that the hydrogel-based structure.
As a biomimetic structure for electrosurgery training,
The structure includes a material having electrical conductivity,
The material is a biomimetic structure for electrosurgery training, characterized in that it contains moisture so that evaporation or incision occurs according to the contact of the electric cauterizer.
The method of claim 6,
The structure is a biomimetic structure for electrosurgery training, characterized in that it evaporates at a predetermined specific temperature or higher according to the electric energy applied to the electric cautery, and is physically cut in a predetermined temperature range.
The method of claim 6,
The biomimetic structure for electrosurgery training, characterized in that the blood vessel simulation channel or the nerve simulation channel in which the blood simulation solution is accommodated is provided inside the surgical training biomimetic structure.
The method of claim 8,
The blood vessel simulation channel is a plurality, and the plurality of channels is a biometric structure for electrosurgery training, characterized in that accommodated a blood simulation solution of a different color.
As a material for a biomimetic structure for electrosurgery training,
gelatin; And
Containing carrageenan, the gelatin and the carrageenan material for a biomimetic structure for surgical training, characterized in that it has mechanical rigidity and conductivity through the pi-Pi bond.

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