KR20210047425A - Cosmetic Composition for Enhancing Skin - Google Patents
Cosmetic Composition for Enhancing Skin Download PDFInfo
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- KR20210047425A KR20210047425A KR1020190130878A KR20190130878A KR20210047425A KR 20210047425 A KR20210047425 A KR 20210047425A KR 1020190130878 A KR1020190130878 A KR 1020190130878A KR 20190130878 A KR20190130878 A KR 20190130878A KR 20210047425 A KR20210047425 A KR 20210047425A
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- cosmetic composition
- resveratrol
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- polyol
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- 239000000203 mixture Substances 0.000 title claims abstract description 55
- 239000002537 cosmetic Substances 0.000 title claims abstract description 35
- 230000002708 enhancing effect Effects 0.000 title 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims abstract description 29
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims abstract description 28
- 235000021283 resveratrol Nutrition 0.000 claims abstract description 28
- 229940016667 resveratrol Drugs 0.000 claims abstract description 28
- 229920005862 polyol Polymers 0.000 claims description 12
- 150000003077 polyols Chemical class 0.000 claims description 12
- 239000004094 surface-active agent Substances 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 239000004359 castor oil Substances 0.000 claims description 6
- 235000019438 castor oil Nutrition 0.000 claims description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 6
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 3
- 208000007542 Paresis Diseases 0.000 claims description 2
- 208000012318 pareses Diseases 0.000 claims description 2
- 229940097941 polyglyceryl-10 laurate Drugs 0.000 claims description 2
- LUKBXSAWLPMMSZ-UHFFFAOYSA-N resveratrol Chemical compound C1=CC(O)=CC=C1C=CC1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-UHFFFAOYSA-N 0.000 claims 1
- 238000009472 formulation Methods 0.000 abstract description 15
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 235000016709 nutrition Nutrition 0.000 abstract 1
- 230000035764 nutrition Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 11
- 230000003381 solubilizing effect Effects 0.000 description 8
- 239000004615 ingredient Substances 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 3
- 125000005250 alkyl acrylate group Chemical group 0.000 description 3
- SWQUTKGVXGTROS-UHFFFAOYSA-N bis(2-ethoxyethyl) butanedioate Chemical compound CCOCCOC(=O)CCC(=O)OCCOCC SWQUTKGVXGTROS-UHFFFAOYSA-N 0.000 description 3
- 229920006037 cross link polymer Polymers 0.000 description 3
- 229940119676 diethoxyethyl succinate Drugs 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229960002104 cyanocobalamin Drugs 0.000 description 2
- 235000000639 cyanocobalamin Nutrition 0.000 description 2
- 239000011666 cyanocobalamin Substances 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- QWGRWMMWNDWRQN-UHFFFAOYSA-N 2-methylpropane-1,3-diol Chemical compound OCC(C)CO QWGRWMMWNDWRQN-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940100573 methylpropanediol Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 235000020095 red wine Nutrition 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
본 발명은 레스베라트롤을 함유하는 피부 개선용 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition for improving skin containing resveratrol.
천연 폴리페놀 물질 중 하나로, 레드 와인에 함유되어 건강에 유익하다고 알려진 레스베라트롤(resveratrol)은 강력한 항산화제 및 미백효과 등의 효능으로 널리 알려져 있다.As one of the natural polyphenols, resveratrol, which is contained in red wine and known to be beneficial to health, is widely known for its potent antioxidant and whitening effects.
그러나, 레스베라트롤은 난용성 물질로 유화 타입에는 적용된 사례가 많으나, 투명한 가용화 제형에 고함량으로 함유시키기 어려운 문제점이 있다. 기존 제품들은 레스베라트롤의 함량을 극소량(컨셉 함량)으로 배합하거나, 용해도를 높이기 위해 레스베라트롤 유도체 사용 등의 방법을 적용하였다.However, resveratrol is a poorly soluble substance and has been applied to an emulsified type in many cases, but it is difficult to contain it in a high content in a transparent solubilizing formulation. Existing products have applied methods such as blending the content of resveratrol in a very small amount (concept content) or using a resveratrol derivative to increase the solubility.
이에, 레스베라트롤을 투명한 가용화 제형에 고함량으로 적용시킬 수 있는 피부 개선용 화장료 조성물의 개발이 요구되고 있다.Accordingly, there is a need to develop a cosmetic composition for improving skin that can apply resveratrol to a transparent solubilizing formulation in a high content.
본 발명자들은 고함량의 레스베라트롤을 함유하면서 제형의 안정성이 확보된 피부 개선용 화장료 조성물을 개발하고자 예의 연구 노력하였다. 그 결과, 계면활성제 및 다가 알코올(폴리올)을 특정 함량비로 포함시켜 혼합하는 경우 레스베라트롤의 수용액 가용화를 위한 특정 성분의 사용 없이도 다량의 레스베라트을 함유하면서 투명한 가용화 제형의 안정성이 확보될 수 있음을 규명함으로써, 본 발명을 완성하게 되었다.The present inventors have made intensive research efforts to develop a cosmetic composition for improving skin that contains a high content of resveratrol while ensuring the stability of the formulation. As a result, it was found that when a surfactant and a polyhydric alcohol (polyol) are included in a specific content ratio and mixed, the stability of a transparent solubilizing formulation can be secured while containing a large amount of resverat without the use of specific components for solubilizing an aqueous solution of resveratrol. By doing so, the present invention has been completed.
따라서, 본 발명의 목적은 레스베라트롤(resveratrol), 계면활성제 및 폴리올(polyol)을 포함하는 피부 개선용 화장료 조성물을 제공하는 것이다.Accordingly, an object of the present invention is to provide a cosmetic composition for improving skin comprising resveratrol, a surfactant, and a polyol.
본 발명자들은 고함량의 레스베라트롤을 함유하면서 제형의 안정성이 확보된 피부 개선용 화장료 조성물을 개발하고자 예의 연구 노력하였다. 그 결과, 계면활성제 및 다가 알코올(폴리올)을 특정 함량비로 포함시켜 혼합하는 경우 레스베라트롤의 수용액 가용화를 위한 특정 성분의 사용 없이도 다량의 레스베라트을 함유하면서 투명한 가용화 제형의 안정성이 확보될 수 있음을 규명하였다.The present inventors have made intensive research efforts to develop a cosmetic composition for improving skin that contains a high content of resveratrol while ensuring the stability of the formulation. As a result, it was found that when a surfactant and a polyhydric alcohol (polyol) are included in a specific content ratio and mixed, the stability of a transparent solubilizing formulation can be secured while containing a large amount of resverat without the use of specific components for solubilizing an aqueous solution of resveratrol. I did.
이하, 본 발명을 더욱 자세히 설명하고자 한다.Hereinafter, the present invention will be described in more detail.
본 발명의 일 양태는 레스베라트롤(resveratrol), 계면활성제 및 폴리올(polyol)을 포함하는 피부 개선용 화장료 조성물에 관한 것이다.One aspect of the present invention relates to a cosmetic composition for improving skin comprising resveratrol, a surfactant, and a polyol.
상기 계면활성제는 피이지-60하이드로제네이티드캐스터오일, 피이지-40하이드로제네이티드캐스터오일, 옥틸도데세스-16, 콜레스-24, C12-14파레스-12 및/또는 폴리글리세릴 계열(예를 들어, 폴리글리세릴-10라우레이트)일 수 있으나, 이에 제한되는 것은 아니다.The surfactants are PEG-60 hydrogenated castor oil, PEG-40 hydrogenated castor oil, octyldodeces-16, Coles-24, C12-14 pares-12 and/or polyglyceryl series (e.g. For example, polyglyceryl-10 laurate) may be, but is not limited thereto.
상기 계면활성제는 화장료 조성물 총 중량에 대하여 0.1 중량% 내지 2.0 중량% 포함될 수 있다. 상기 계면활성제가 상기 범위 밖에서 실시되는 경우 전체 조성물 안정성이 저해되어 실사용이 어려운 문제가 발생 할 수 있고, 레스베라트롤이 석출되어 투명한 제형을 얻을 수 없는 문제점이 발생할 수 있다.The surfactant may be included in an amount of 0.1% to 2.0% by weight based on the total weight of the cosmetic composition. When the surfactant is carried out outside the above range, the stability of the entire composition may be impaired, making it difficult to use, and resveratrol may be precipitated to obtain a transparent formulation.
상기 폴리올은 글리세린, 부틸렌글라이콜, 프로판디올 및/또는 디프로필렌글라이콜, 메칠프로판디올, 메칠글루세스-10일 수 있으나, 이에 제한되는 것은 아니다.The polyol may be glycerin, butylene glycol, propanediol and/or dipropylene glycol, methylpropanediol, methylgluces-10, but is not limited thereto.
상기 폴리올은 화장료 조성물 총 중량에 대하여 1 중량% 내지 60 중량% 포함될 수 있다. 상기 폴리올이 상기 범위 밖에서 실시되는 경우 전체 조성물 안정성이 저해되어 실사용이 어려운 문제가 발생 할 수 있고, 레스베라트롤이 석출되어 투명한 제형을 얻을 수 없는 문제점이 발생할 수 있다.The polyol may be included in an amount of 1% to 60% by weight based on the total weight of the cosmetic composition. When the polyol is carried out outside the above range, the stability of the entire composition may be impaired, making it difficult to use, and resveratrol may be precipitated to obtain a transparent formulation.
상기 화장료 조성물은 점증제를 더 포함할 수 있다.The cosmetic composition may further include a thickener.
상기 점증제는 예를 들어 잔탄검, 아크릴레이트/C10-30알킬아크릴레이트크로스폴리머, 암모늄아크릴로일디메칠타우레이트브이피코폴리머 및/또는 카보머일 수 있으나, 이에 제한되는 것은 아니다.The thickener may be, for example, xanthan gum, acrylate/C10-30 alkyl acrylate crosspolymer, ammonium acryloyldimethyltaurate VP copolymer and/or carbomer, but is not limited thereto.
상기 화장료 조성물은 상기 기재된 성분 외에 정제수, 보습제, 중화제, 방부제 등을 더 포함할 수 있다.The cosmetic composition may further include purified water, a moisturizing agent, a neutralizing agent, a preservative, and the like in addition to the above-described components.
상기 화장료 조성물은 이의 화장품학적 유효량(cosmetically effective amount) 및/또는 화장품학적으로 허용되는 담체를 포함하는 것일 수 있으나, 이에 한정되는 것은 아니다.The cosmetic composition may include a cosmetically effective amount thereof and/or a cosmetically acceptable carrier, but is not limited thereto.
본 명세서에서 용어 "화장품학적 유효량"은 상술한 본 발명의 조성물의 효능을 달성하는 데 충분한 양을 의미한다.As used herein, the term "cosmetically effective amount" means an amount sufficient to achieve the efficacy of the composition of the present invention described above.
상기 화장료 조성물은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있다.The cosmetic composition may be prepared in any formulation conventionally prepared in the art.
본 발명의 화장료 조성물에 포함되는 성분은 유효 성분과 담체 성분 외에, 화장품 조성물에 통상적으로 이용되는 성분들을 포함하며, 예를 들어 항산화제, 안정화제, 용해화제, 비타민 및 향료와 같은 통상적인 보조제를 포함할 수 있다.Ingredients included in the cosmetic composition of the present invention include ingredients commonly used in cosmetic compositions in addition to the active ingredient and the carrier ingredient, for example, conventional adjuvants such as antioxidants, stabilizers, solubilizers, vitamins and fragrances. Can include.
본 발명은 레스베라트롤을 함유하는 피부 개선용 화장료 조성물에 관한 것으로, 본 발명의 화장료 조성물은 다량의 레스베라트롤을 포함하면서도 투명한 제형의 안정성을 제공함으로써, 오일처럼 부드럽게 펴 발리며 흡수 후 끈적임 없이 영양감을 부여할 수 있는 피부 개선용 화장료 조성물의 용도로 유용하게 사용될 수 있다. The present invention relates to a cosmetic composition for improving skin containing resveratrol, wherein the cosmetic composition of the present invention contains a large amount of resveratrol and provides stability of a transparent formulation, so that it spreads smoothly like an oil and gives a nourishment without stickiness after absorption. It can be usefully used as a cosmetic composition for improving skin that can be used.
도 1은 본 발명의 실시예에 의해 제조된 화장료 조성물의 제형 안정성을 확인한 결과이다.1 is a result of confirming the formulation stability of a cosmetic composition prepared according to an embodiment of the present invention.
이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본 발명의 요지에 따라 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 당업계에서 통상의 지식을 가진 자에 있어서 자명할 것이다.Hereinafter, the present invention will be described in more detail through examples. These examples are only for describing the present invention in more detail, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not limited by these examples according to the gist of the present invention. .
실시예. 본 발명의Example. Of the present invention 화장료 조성물의 제조Preparation of cosmetic composition
하기 표 1에 나타낸 함량비에 따라, 글리세린, 부틸렌글리콜, 프로판디올 및 피이지-60하이드로제네이티드캐스터오일을 비이커에 계량한 후 호모믹서(HOMO Mixer)를 이용하여 50℃에서 HM 2500, 25rpm으로 5분 동안 혼합하였다. 그 다음, 그 외 나머지 성분을 첨가하고 30℃에서 HM 2500, 25rpm으로 3분 동안 혼합하여 화장료 조성물을 제조하였다.According to the content ratio shown in Table 1 below, after weighing glycerin, butylene glycol, propanediol, and PEG-60 hydrogenated castor oil in a beaker, HM 2500, 25 rpm at 50°C using a homomixer. And mixed for 5 minutes. Then, the remaining ingredients were added and mixed at 30° C. with HM 2500 and 25 rpm for 3 minutes to prepare a cosmetic composition.
비교예. 일부 성분 변화에 따른 화장료 조성물의 제조Comparative example. Preparation of cosmetic composition according to some component changes
하기 표 2에 나타낸 함량비에 따라, 상기 실시예와 동일한 방법을 사용하여 화장료 조성물을 제조하였다.According to the content ratio shown in Table 2 below, a cosmetic composition was prepared using the same method as in the above Example.
실험예 1. 화장료 조성물의 성상 평가Experimental Example 1. Evaluation of properties of cosmetic composition
도 1a 및 1b에서 확인할 수 있듯이, 실시예(도 1a)의 경우 투명한 가용화 제형 구현이 구현되었으며, 저온 안정도가 관찰되었다.As can be seen in Figures 1a and 1b, in the case of Example (Figure 1a), a transparent solubilizing formulation was implemented, and low temperature stability was observed.
반면, 비교예 1(도 1b) 및 2의 경우 난용성 물질의 용해를 돕는 디에톡시에칠석시네이트를 10 중량% 첨가하였음에도 레스베라트롤이 용해되지 않아 제형이 현탁하고, 부분적으로 레스베라트롤이 석출된 성상의 매끈하지 않은 화장료 조성물을 얻을 수 있었다.On the other hand, in the case of Comparative Examples 1 (Fig. 1b) and 2, even though 10% by weight of diethoxyethylsuccinate, which helps dissolution of poorly soluble substances, was added, resveratrol was not dissolved, so the formulation was suspended, and partially resveratrol was precipitated. It was possible to obtain a cosmetic composition that was not smooth.
또한, 비교예 3 및 4와 같이 레스베라트롤을 2.0 중량% 초과하여 포함하는 경우(2.5 중량%) 계면활성제를 다량 첨가하여도 레스베라트롤이 석출된 성상의 매끈하지 않은 화장료 조성물을 얻을 수 있었다.In addition, as in Comparative Examples 3 and 4, when containing more than 2.0% by weight of resveratrol (2.5% by weight), even if a large amount of surfactant was added, a non-smooth cosmetic composition in which resveratrol was precipitated was obtained.
나아가, 비교예 5와 같이 폴리올을 1.0 중량% 미만으로 포함하거나(0.5 중량%) 비교예 6과 같이 계면활성제를 0.1 중량% 미만으로 포함하는 경우(0.6 중량%)에도 레스베라트롤이 석출된 성상의 매끈하지 않은 화장료 조성물을 얻을 수 있었다.Furthermore, even when containing less than 1.0% by weight of polyol as in Comparative Example 5 (0.5% by weight) or less than 0.1% by weight of a surfactant as in Comparative Example 6 (0.6% by weight), the properties in which resveratrol was precipitated were smooth. It was possible to obtain a cosmetic composition that was not.
소결Sintering
본 발명의 화장료 조성물은 다량의 레스베라트롤(1 내지 2.0 중량%)을 포함하면서도 투명한 가용화 제형의 안정성을 제공함으로써, 난용성 물질로 잘 용해 되지 않아 유화 타입에만 적용이 용이했던 레스베라트롤의 용해도를 개선시킨 것을 특징으로 한다.The cosmetic composition of the present invention contains a large amount of resveratrol (1 to 2.0% by weight) while providing the stability of a transparent solubilizing formulation, thereby improving the solubility of resveratrol, which was not well soluble as a poorly soluble substance and was easy to apply only to the emulsified type. It is characterized.
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