KR20180104858A - Apparatus and method of sensing glucose using electromagnetic wave and multi cavity resonance - Google Patents

Abstract

The present invention relates to a glucose concentration measurement apparatus, including a source unit generating electromagnetic field energy having a predetermined frequency, a sensor unit receiving the electromagnetic field energy generated from the source unit, irradiating a measurement object with the energy, and detecting an electric wave reflected from the measurement object, and a processing unit determining the resonance frequency of the sensor unit by controlling the source unit and calculating a change in the glucose concentration amount of the measurement object from a change in the resonance frequency and reflectance of the electric wave detected through the sensor unit. The sensor unit includes a plurality of cavity resonators interacting with the measurement object and a hole is formed inside the center so that the measurement object is inserted into the inside center for interaction with the measurement object. According to the present invention, it is possible to significantly improve resolution by means of a multi-cavity resonator sensor-type diabetic sensor and real-time diabetic measurement and blood sugar monitoring can be performed.

Description

[0001] The present invention relates to an apparatus and method for measuring glucose concentration using electromagnetic waves and multi-cavity resonance,

The present invention relates to an apparatus and method for measuring glucose concentration, and more particularly, to an apparatus and method for measuring glucose concentration in a non-invasive manner using a plurality of multi-cavity resonances.

Diabetes mellitus is a type of metabolic disease that lacks insulin secretion or does not function normally. It is characterized by hyperglycemia in which the concentration of glucose in the blood rises. Hyperglycemia causes various symptoms and signs and excretes glucose from the urine . Many diseases, including diabetes, can detect abnormalities in health through blood sugar, so many of the medical diagnoses often involve blood glucose measurement.

A conventional blood glucose measuring device currently in use includes a blood glucose measuring device for measuring blood glucose by collecting blood from a patient. Among these, the blood glucose measuring device is a device that can easily purchase test strips from a pharmacy and can measure blood glucose through blood collection. It is a device that can manage diabetes by checking blood glucose level easily at home.

However, the blood glucose meter needs to be collected every time blood glucose measurement, additional disinfection to prevent infection of the blood collection site, and pain and hygiene problems are required because the needle must be used for blood collection. Recently, a diabetic phone capable of measuring blood sugar using a mobile phone has been introduced regardless of the place. However, the configuration and principle of the conventional blood glucose meter are not so different from those of the conventional blood glucose meter in that blood collection must be accompanied.

Non-invasive blood glucose measurement method and apparatus therefor (Korean Patent Laid-open No. 10-2016-0075230)

SUMMARY OF THE INVENTION The present invention provides a glucose concentration measuring device for measuring glucose concentration in a non-invasive manner using a plurality of multi-cavity resonances, which improves resolution and accuracy of measurement.

In order to achieve the above-described object, the present invention provides a plasma processing apparatus comprising: a source for generating electromagnetic energy of a predetermined frequency; A sensor unit for receiving electromagnetic field energy generated from the source unit, irradiating the object to be measured with the electromagnetic field energy, and detecting a radio wave reflected from the object to be measured; And a processing unit for controlling the source unit to determine a resonance frequency of the sensor unit and calculating a change in glucose concentration of the measured object from a change in resonance frequency and reflectance of the radio wave detected through the sensor unit, Wherein the cavity is formed by a plurality of cavity resonators interacting with the object to be measured and a hole is formed at an inner center of the cavity so that the object to be measured is inserted into the center inside to interact with the object to be measured And a glucose concentration measuring device for measuring glucose concentration.

According to an embodiment of the present invention, the sensor unit may include: a first cavity resonator having a hole formed at an inner center thereof and the object to be measured inserted into the center of the cavity; And a plurality of second cavity resonators placed in contact with the side surfaces of the first resonator.

According to an embodiment of the present invention, the second cavity resonator may be a rectangular shape.

According to an embodiment of the present invention, the hole formed in the center of the sensor unit is formed in such a manner that the object to be measured can be fixed so that the measured object is positioned at the center of the first cavity resonator. Concentration measuring device.

According to an embodiment of the present invention, the hole formed in the center of the sensor unit may be formed in a cylindrical shape or a ring shape.

According to the embodiment of the present invention, the processing unit calculates the change in the graphical area with respect to the reflectance of the detected radio wave, and calculates the glucose concentration of the measured object by using the change in the area of the graph of the calculated reflectivity And the glucose concentration measuring device may be a glucose concentration measuring device.

According to an embodiment of the present invention, the sensor unit detects a radio wave reflected from the measured object using a dielectric permittivity according to a reflection coefficient and a frequency change according to a glucose concentration in the measured object And a glucose concentration measuring device.

According to an embodiment of the present invention, the dielectric constant is determined by a combination of electric energy in the measured object and loss of the electric energy.

According to an embodiment of the present invention, the processing unit generates visual data on the quantitative change of the amount of glucose concentration of the measured object by comparing the change of the resonance frequency and the reflectance of the radio wave detected through the sensor unit with a previously stored database and,

And a display unit for displaying the generated visual data.

According to an embodiment of the present invention, the sensor unit may be a device for measuring glucose concentration, which non-invasively examines the measured object.

In order to achieve the above object, the present invention provides an apparatus for measuring blood glucose with a non-invasive sensor, wherein the sensor has a hole formed at an inner center thereof, And a plurality of second cavity resonators placed in contact with a side surface of the first resonator, wherein the first cavity resonator and the second cavity resonator are arranged to irradiate electromagnetic energy to the measured object, And detects a change in resonance frequency and reflectance of a radio wave reflected from the measured object as a result of the interaction.

According to another aspect of the present invention, there is provided a method of measuring an object to be measured, the method comprising: inserting the object to be measured into a hole formed in a center of a sensor having a plurality of cavity resonators interacting with the object to be measured; Generating and inputting electromagnetic energy of a predetermined frequency from a source; The sensor irradiating the object to be measured with the input electromagnetic field energy; Detecting a radio wave reflected from the measured object by the sensor; And calculating a change in the amount of glucose concentration of the measured object from a change in the resonance frequency and reflectance of the detected radio wave, wherein a hole formed in the center of the sensor causes the measured object to be in contact with the center of the cavity resonator The object to be measured is fixed so that the reproducibility of the sensor is maintained at a predetermined level or higher.

The present invention greatly improves the resolution by using a sugar sensor in the form of a multi-cavity resonator sensor, and can monitor glucose in real time in the measurement of sugar beet. And it is convenient to manufacture and accurate blood glucose measurement is possible.

1 shows an apparatus for measuring glucose concentration according to an embodiment of the present invention.
2 and 3 are views showing a sensor unit of the glucose concentration measuring apparatus according to an embodiment of the present invention.
FIGS. 4 and 5 are views for explaining a process of calculating a change in the amount of glucose in the object by measuring a change in the decomposition rate of the detected radio wave.
6 is a flowchart of a glucose concentration measurement method according to an embodiment of the present invention.

Prior to the description of the concrete contents of the present invention, for the sake of understanding, the outline of the solution of the problem to be solved by the present invention or the core of the technical idea is first given.

The apparatus for measuring glucose concentration according to an embodiment of the present invention includes a source for generating electromagnetic energy of a predetermined frequency, an electromagnetic energy generated from the source for receiving the electromagnetic energy, And a control unit for controlling the source unit to determine a resonance frequency of the sensor unit and determining a glucose concentration value of the measured object from a change in resonance frequency and reflectance of the radio wave detected through the sensor unit Wherein the sensor unit includes a plurality of cavity resonators that interact with the measured object, and a hole is formed at an inner center of the cavity, so that the measured object is inserted into the center inside Thereby interacting with the measured object.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. It will be apparent to those skilled in the art, however, that these examples are provided to further illustrate the present invention, and the scope of the present invention is not limited thereto.

BRIEF DESCRIPTION OF THE DRAWINGS The above and other features and advantages of the present invention will become more apparent from the following detailed description of the present invention when taken in conjunction with the accompanying drawings, It is to be noted that components are denoted by the same reference numerals even though they are shown in different drawings, and components of different drawings can be cited when necessary in describing the drawings. In the following detailed description of the principles of operation of the preferred embodiments of the present invention, it is to be understood that the present invention is not limited to the details of the known functions and configurations, and other matters may be unnecessarily obscured, A detailed description thereof will be omitted.

Before describing the embodiments of the present invention, a basic idea that the embodiments are commonly employed will be presented. As described above, in order to solve the problems (pain, unsanitary) of a conventional blood glucose measuring device, the embodiments of the present invention have focused on a method of measuring glucose concentration or blood sugar through a non-invasive method.

For this non-invasive blood glucose measurement, the following examples utilize the property of changing the dielectric property through glucose-induced from the blood in human tissue. In addition, the following embodiments are intended to measure the blood glucose of an object to be measured using electromagnetic (EM) without direct contact with blood in the object to be measured for non-invasive blood glucose measurement. Such electromagnetic media may include radio waves, in particular microwaves. Embodiments of the present invention include a microwave sensor that can be used to non-invasively determine the glucose concentration in a measured object and to monitor the change in real time, .

According to the method of measuring glucose response using a single probe that emits microwaves in accordance with a near-field principle, many errors are caused according to measurement positions, irregular noise flows in accordance with changes in measurement positions, Have been found to have a negative impact on the sensitivity and stability of blood glucose measurement.

Therefore, embodiments of the present invention to be described below propose an apparatus and method for more accurately detecting glucose concentration and blood sugar by utilizing a cavity resonator having a hole formed inside the center of a sensor unit, rather than a single probe provided outside do.

In addition, when one cavity resonator is used, resolution may be weak. To overcome this problem, a plurality of cavity resonators are used. By using a plurality of cavity resonances, the value of Q (quality factor) can be increased, and qualitative and quantitative measurement can be performed through it, thereby enabling more accurate detection and evaluation.

In the following, embodiments of the present invention will be described in more detail with reference to the related drawings. In the drawings, like reference numerals refer to like elements.

FIG. 1 is a block diagram of an apparatus for measuring glucose concentration according to an embodiment of the present invention. The apparatus for measuring glucose concentration 110 includes a source unit 111, a sensor unit 112, a processing unit 113, And may further include a database 115 or a display unit 116. [

The source part 111 generates electromagnetic energy corresponding to a certain range of frequencies. The electromagnetic energy may be various energy sources capable of reacting with the glucose in the measured object 120. In this embodiment, a method of using radio waves is exemplified. In particular, interaction with a measured object is considered And a set microwave can be utilized. The electromagnetic energy is controlled by the processing unit 113 to be described later to generate a frequency level suitable for the object to be measured. The object to be measured may be a glucose solution or a specific part of the human body to measure blood glucose, for example, a finger.

The sensor unit 112 receives the electromagnetic field energy generated from the source unit, irradiates the object to be measured, and detects a radio wave reflected from the object to be measured. Particularly, in the embodiments of the present invention, the sensor unit 112 is constituted by a plurality of cavity resonators that interact with the measured object, holes are formed in the center inside thereof, Thereby interacting with the measured object. That is, the sensor unit 112 according to the embodiments of the present invention directly irradiates electromagnetic field energy by placing a sample (blood sugar) of an object to be measured directly at the center of the sensor unit instead of a separate external probe, The reflectance is detected. The sensor unit 112 can directly react with the measured object through a hole formed in the center. That is, the holes formed in the center of the sensor unit 112 are preferably formed in such a manner that the measured object can be fixed so that the measured object is located at the center of the sensor unit 112. For this purpose, it is preferable that the holes formed in the center of the sensor unit 112 are formed in a cylinder or a ring shape, but the practical configuration of such holes is not limited to the general knowledge in the technical field of the present invention The present invention can be flexibly designed and implemented within the scope of the technical idea of the present invention.

Particularly, the formed holes not only allow the object to be measured to be directly positioned at the center of the sensor unit, but also function to securely fix the object to be measured and prevent the measurement position from being changed. With this configuration, irregular noise and measurement inhomogeneity can be prevented from occurring without changing the measurement position of the measured object even in a plurality of measurement processes. Reproducibility refers to reproducibility, which means that the same measurand can be measured in the same manner as the measurer, the device, the place of measurement, all of the measurement period, or any of the other conditions. And the nature or degree of agreement between the individual measurements. Therefore, it is preferable that the positions of the cavity and the cavity resonator implemented through the embodiments of the present invention are realized so that a certain level of reproducibility can be maintained through a plurality of experiments and measurement results. That is, this reproducibility depends on how consistently the blood glucose measurement results for the object to be measured can be obtained.

The sensor unit 112 may include a plurality of cavity resonators. Specifically, the sensor unit 112 may include a first cavity resonator in which a hole is formed at an inner center of the cavity and the object to be measured is inserted in the center of the cavity, The second cavity resonator may include a plurality of second cavity resonators.

When the glucose concentration is measured using only one cavity resonator having a hole at the center inside thereof, there is a problem that the resolution may be insufficient. In order to improve the resolution, as shown in FIGS. 2 and 3, the first cavity resonator 210 The second cavity resonators 220 can be disposed in the periphery of the second cavity resonators 220 to enhance the resolution. Thus, the Q value can be improved. The number of the second cavity resonators 220 may be predetermined or may vary depending on the required specification or user and may be implemented in a form that is symmetrical about the first cavity resonator 210 in a rectangular shape have. But it is natural that it can be implemented in other forms. The second cavity resonator 220 may be located at the highest measurement efficiency in the hole formed in the second cavity resonator 220 and the position may be calculated through simulation or the like. The cavity resonator may be a dielectric resonator, and there is no particular limitation on the type of the dielectric for implementing the dielectric resonator, and a suitable dielectric may be selected by those skilled in the art.

With this configuration, it is possible to solve the conventional problem that the measurement result of the glucose concentration changes unexpectedly according to the position of the measured object in contact with the conventional external probe, irregular noise and measurement inhomogeneity appear in the measurement result, .

The glucose concentration measuring apparatus 110 according to the embodiment of the present invention may measure the energy of the electromagnetic field generated from the source unit 111 in the cavity resonator 112 of the sensor unit 112, The blood glucose of the patient is measured while reacting with the glucose solution (in the case of the human body, blood inside the human body) in the object to be measured. More specifically, the sensor unit 112 detects a wave reflected from the measured object 120 using a reflection coefficient according to the glucose concentration in the measured object 120 and a dielectric constant according to the frequency change. At this time, this dielectric constant is determined by the combination of the electric energy in the measured object 120 and the loss of electric energy.

The processing unit 113 determines the resonance frequency of the sensor unit 112 by controlling the source unit 111 and detects the resonance frequency of the measured object 120 from the change of the resonance frequency and reflectance of the radio wave detected through the sensor unit 112 And the change in the amount of glucose concentration is calculated. The processor 113 can measure the glucose concentration from a non-direct measurement of the dielectric constant or a direct measurement of the reflection coefficient of the microwave using analysis of the microwave signal of glucose. The parameter used in the processing unit 113 is a dielectric permittivity, which is one of the main material characteristics of the medium.

In summary, the sensor unit 112 measures the change in the reflection coefficient of the resonator contacting the measured object 120 at a resonance frequency of a certain range to determine a change in glucose concentration. The electromagnetic wave interaction between the microwave sensor unit 112 and the measured object 120 causes a change in the reflection coefficient and it is confirmed that this change is directly related to the glucose concentration change. Then, the processing unit 113 can determine the glucose concentration in real time through the change in the microwave reflection coefficient measured through the sensor unit 112.

In order to confirm a more accurate glucose concentration, the processing unit 113 calculates the change of the area on the graph with respect to the reflectance of the detected radio wave as shown in Fig. 4, The change of the blood sugar amount of the measured object can be calculated. As shown in FIG. 5, it can be seen that the case where the change in reflectance area is calculated and used is easier to distinguish the glucose concentration than in the case of calculating the change in the position of min of the reflectance. Therefore, the processing unit 113 calculates the change in the graphical area with respect to the reflectance of the detected radio wave, and calculates the change in the blood sugar amount of the measured object using the change in the graphical area of the calculated reflectance, .

The processing unit 113 compares the change of the resonance frequency and the reflectance of the radio wave detected through the sensor unit 112 with the previously stored database 115 to obtain a visual change of the quantitative change of the amount of glucose concentration of the measured object 120 Data can be generated. In addition, the glucose concentration measuring device 110 can display the visual data generated through the display unit 114. [ Such a display unit 114 may optionally be included according to an embodiment in which an embodiment of the present invention is implemented.

In the meantime, the non-invasive sensor according to the present embodiment includes a cavity resonator that has a hole formed inside a center portion of the sensor and can directly interact with a measured object, thereby irradiating a microwave to a measured object through a cavity resonator, As a result of the interaction with the object to be measured, a change in the resonance frequency and reflectance of the wave reflected from the object to be measured is detected. For this purpose, the non-invasive sensor uses the dielectric constant according to the reflection coefficient and the frequency change according to the glucose concentration in the measured object.

Now, let's look at the implementation principle and the theory of this embodiment in more detail.

The measurement of blood glucose through the dielectric resonator commonly adopted in the embodiments of the present invention is dependent on the reflection coefficient and the frequency change depending on the glucose concentration. The operating principles of these sensors are based on a change in the reflection coefficient S ₁₁ and the resonance frequency f ₀ parameter from a change in the characteristics of the measured object, such as dielectric permittivity and magnetic permeability, Based.

First, the susceptibility depends on the change in magnetic energy in the material. In general, most of the diamagnetic or paramagnetic materials are not affected by external magnetic fields because they do not have strong magnetic field properties. On the other hand, ferromagnetic material, which is a nonlinear medium, is strongly influenced by external magnetic field change. However, most biological samples are hardly affected by external magnetic fields. Thus, the susceptibility, which is one of the characteristics of such a measured object in terms of embodiments of the present invention with respect to the glucose level in the human body, can be ignored.

Next, let's look at one of the other important characteristic parameters of the measured object, the dielectric constant. The dielectric constant has a complex-type characteristic as shown in the following Equation 1, depending on the material.

는 실수부로서 물질 내의 전기 에너지에 의해 결정된다. 전자기(EM) 신호가 물질을 통과할 때, 허수부

는 에너지 손실

에 의해 결정된다. 글루코스 솔루션에서 덱스트로오스(dextrose)의 유전상수는 몰농도 증가분 δ에 의해 이상의 수학식 1로부터 다음의 수학식 2와 같이 표현될 수 있다.In Equation (1)

Is determined by electrical energy in the material as a real part. When an electromagnetic (EM) signal passes through the material,

Energy loss

. In the glucose solution, the dielectric constant of dextrose can be expressed by the molar concentration increment [delta] from the above equation (1) as follows.

는 37℃에서

(mg/dl)^{- 1}과

(mg/dl)^-1에 의한 글루코스 농도의 유니트(unit) 증가분이고,

는 증류수(de-ionized water, DI water)의 유전상수다. 이 때, 증류수의 실수부와 허수부의 복소수 유전상수는 다음의 수학식 3과 같이 표현될 수 있다. In Equation (2), the constant c is the concentration of glucose,

Lt; / RTI >

(mg / dl) ^{- 1} and

(mg / dl) < ^-1 >

Is the dielectric constant of de-ionized water (DI water). At this time, the complex dielectric constant of the real part and the imaginary part of the distilled water can be expressed by the following equation (3).

Ε _∞ in the equation (3) is a dielectric constant in the high frequency area, ε _s is the dielectric constant of the low-frequency domain, τ denotes the characteristic relaxation time of the material.

The dielectric constant, which is an important characteristic parameter of the object to be measured, can be determined as described above. The change in the dielectric constant is represented by a change in the characteristics of the object to be measured, and the change in the reflection coefficient S ₁₁ and the resonance frequency f ₀ Can be derived. The change in the wave pattern of the microwave propagating through the dielectric resonator due to the interaction with the object to be measured is due to the fact that the dielectric constant changes according to the glucose concentration of the object to be measured and thus the reflection coefficient S ₁₁ changes.

The variation of the reflection coefficient S ₁₁ according to the glucose concentration amount shows that the center frequency, the peak value, and the area of the reflection coefficient vary depending on the amount of glucose concentration. In the apparatus for measuring glucose concentration according to an embodiment of the present invention, since a microwave having a constant bandwidth is irradiated on a measured object by a sensor, a frequency band is shifted in a microwave detected after interaction. That is, the waveform change pattern of the microwave is measured through the sensor, and the processing unit calculates data on the amount of glucose concentration from the measured value. In particular, more accurate concentration measurement is possible by using the graphical area of the reflection coefficient. At this time, the amount of glucose concentration can be calculated from the database of the relationship between the measured waveform change pattern and the previously prepared waveform change pattern and the glucose concentration amount. The measurement of the waveform change pattern can be performed by, for example, a method of measuring an area in a graph expressed by a frequency versus amplitude of a microwave and measuring a change in power of the microwave from the measured area, and the power change can be converted into a voltage.

FIG. 6 is a flowchart illustrating a method for measuring glucose concentration according to an embodiment of the present invention, including steps corresponding to the glucose concentration measuring apparatus of FIG. 1. For convenience of description, only the outline of each step will be described with reference to the correspondence with the configuration of FIG. 1, and a detailed description thereof will be omitted.

In step 610, the object to be measured is inserted into the hole formed in the center of the sensor having the cavity resonator interacting with the object to be measured.

In step 620, the sensor receives electromagnetic field energy of a certain range of frequencies generated from the source.

In step 630, the sensor irradiates the measured object with the electromagnetic field energy input through step 620, and then, in step 640, the sensor detects the electromagnetic wave reflected from the measured object. As described above, such a sensor is manufactured without a separate external single probe, and a hole is formed in the center inside to induce the object to be measured to be positioned at the center of the cavity resonator.

In operation 650, the change in the glucose concentration of the object to be measured is calculated from the change in the resonance frequency and reflectance of the radio wave detected in operation 640. [

According to the embodiments of the present invention described above, it is possible to measure the glucose concentration without taking blood from a patient, and as a result, the inconvenience of pain and unsanitary can be solved. Further, the sensitivity and accuracy of the glucose concentration measurement can be improved by positioning the object to be measured directly at the center of the cavity resonator through a hole formed in the center of the sensor without an external probe.

Meanwhile, the method for measuring glucose concentration according to another embodiment of the present invention may further include the following additional step.

Visual data on the change in the amount of glucose in the measured object is displayed through the display device. For this purpose, in calculating the change of the glucose concentration amount in the step 650, the change of the resonance frequency and the reflectance of the radio wave detected by the sensor is compared with a previously stored database, thereby obtaining visual data on the quantitative change of the glucose concentration amount of the measured object Lt; / RTI > It is needless to say that it is necessary to generate glucose concentration amount information according to the resonance frequency and reflectance of radio waves before these processes are performed and to store them in the database in advance.

According to another embodiment of the present invention, it is possible to provide glucose concentration measuring means capable of monitoring a change in glucose concentration in real time over time.

According to the embodiments of the present invention as described above, blood glucose is directly reacted with the center of the resonator by fixing the object to be measured in a hole formed in the center of the sensor part of the blood glucose measurement device, The sensitivity, accuracy and measurement speed of blood glucose measurement can be improved. In particular, blood glucose can be measured accurately and quickly by directly reacting with blood, and it is possible to obtain a medical diagnosis from a remote physician by measuring changes in blood glucose change in real time.

Meanwhile, the resonator sensor of the blood glucose measurement apparatus according to these embodiments can be replaced by a resonator pattern suitable for the use by a person having ordinary skill in the art to which the present invention belongs. And the structure can be changed and designed, thereby improving the sensitivity of the blood sugar measurement. The internal cavity resonator sensor using the electromagnetic wave can be designed by selecting the frequencies in the MHz range from the GHz range while maintaining stable characteristics with respect to the external probe type sensor. In addition, it is possible to improve the noise-to-signal characteristic and the minimum glucose detection ability, and to make an experimental or diagnostic error that may occur due to a defect such as noise, irregular noise, measurement inhomogeneity, Can be solved.

Further, in order to control the above-described blood glucose measurement apparatus, another embodiment of the present invention can be implemented as a computer-readable code on a computer-readable recording medium. A computer-readable recording medium includes all kinds of recording apparatuses in which data that can be read by a computer system is stored.

Examples of the computer-readable recording medium include a ROM, a RAM, a CD-ROM, a magnetic tape, a floppy disk, an optical data storage device and the like, and also a carrier wave (for example, transmission via the Internet) . In addition, the computer-readable recording medium may be distributed over network-connected computer systems so that computer readable codes can be stored and executed in a distributed manner. In addition, functional programs, codes, and code segments for implementing the present invention can be easily deduced by programmers skilled in the art to which the present invention belongs.

The present invention has been described above with reference to various embodiments. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the disclosed embodiments should be considered in an illustrative rather than a restrictive sense. The scope of the present invention is defined by the appended claims rather than by the foregoing description, and all differences within the scope of equivalents thereof should be construed as being included in the present invention.

110: glucose concentration measuring device
111: source part
112:
113:
114:
115: Database
120: measured object

Claims (14)

A source for generating electromagnetic energy of a predetermined frequency;
A sensor unit for receiving electromagnetic field energy generated from the source unit, irradiating the object to be measured with the electromagnetic field energy, and detecting a radio wave reflected from the object to be measured; And
And a processing unit for determining the resonance frequency of the sensor unit by controlling the source unit and calculating a change in the amount of glucose concentration of the measured object from a change in resonance frequency and reflectance of the radio wave detected through the sensor unit,
The sensor unit includes:
And a plurality of cavity resonators interacting with the object to be measured, wherein a hole is formed at an inner center of the cavity, and the object to be measured is inserted into the center inside to interact with the object to be measured. Concentration measuring device. The method according to claim 1,
The sensor unit includes:
A first cavity resonator in which a hole is formed in the center inside and the object to be measured is inserted in the center inside; And
And a plurality of second cavity resonators located in contact with the side surfaces of the first resonator. 3. The method of claim 2,
Wherein the second cavity resonator comprises:
Wherein the glucose concentration measuring device is a rectangular type measuring device. The method according to claim 1,
The hole formed in the center of the sensor portion is formed,
Wherein the object to be measured is formed to be able to fix the object to be measured so as to be positioned at the center of the first cavity resonator. 5. The method of claim 4,
The hole formed in the center of the sensor portion is formed,
Wherein the electrode is formed in a cylindrical shape or a ring shape. The method according to claim 1,
Wherein,
Wherein a change in the glucose concentration of the measured object is calculated using a change in the area of the graph on the basis of the reflectance of the detected radio wave and a change in the area of the graph on the calculated reflectance, Device. The method according to claim 1,
The sensor unit includes:
Wherein a radio wave reflected from the measured object is detected using a reflection coefficient according to a glucose concentration in the measured object and a dielectric permittivity according to a frequency change. 8. The method of claim 7,
The dielectric constant,
And a loss of electrical energy in the measured object is determined by a combination of the loss of the electrical energy and the electrical energy in the measured object. The method according to claim 1,
Wherein,
Generating a visual data on a quantitative change in the amount of glucose concentration of the measured object by comparing a change in the resonance frequency and reflectance of the radio wave detected through the sensor unit with a previously stored database,
And a display unit for displaying the generated visual data. The method according to claim 1,
The sensor unit includes:
Wherein the non-invasive measurement object is examined non-invasively. An apparatus for measuring blood glucose with a non-invasive sensor,
The sensor includes:
A first cavity resonator in which a hole is formed in the center inside and the object to be measured is inserted in the center, and a plurality of second cavity resonators positioned in contact with the side face of the first resonator,
Irradiating electromagnetic energy to the measured object through the first cavity resonator and the second cavity resonator,
And detects a change in resonance frequency and reflectance of a radio wave reflected from the measured object as a result of interaction with the measured object. 12. The method of claim 11,
The sensor includes:
Calculates a change in the area of the graph on the basis of the reflectance of the detected radio wave and calculates a change in the blood sugar amount of the object to be measured by using the change in the graphical area of the calculated reflectance. Inserting the object to be measured into a hole formed in the center of a sensor having a plurality of cavity resonators interacting with the object to be measured;
Generating and inputting electromagnetic energy of a predetermined frequency from a source;
The sensor irradiating the object to be measured with the input electromagnetic field energy;
Detecting a radio wave reflected from the measured object by the sensor; And
And calculating a change in the amount of glucose concentration of the measured object from a change in the resonance frequency and reflectance of the detected radio wave,
Wherein the holes formed in the center of the sensor hold the object to be measured so that the measured object is positioned at the center of the cavity resonator so that the reproducibility of the sensor is maintained at a predetermined level or higher. 14. The method of claim 13,
The sensor includes:
Wherein a change in the glucose concentration of the measured object is calculated using a change in the area of the graph on the basis of the reflectance of the detected radio wave and a change in the area of the graph on the calculated reflectance, Way.

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