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KR20180101767A - The composition for catheter, the central venous catheter and the intravascular tube catheter prepared by using the same - Google Patents

The composition for catheter, the central venous catheter and the intravascular tube catheter prepared by using the same Download PDF

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KR20180101767A
KR20180101767A KR1020170028128A KR20170028128A KR20180101767A KR 20180101767 A KR20180101767 A KR 20180101767A KR 1020170028128 A KR1020170028128 A KR 1020170028128A KR 20170028128 A KR20170028128 A KR 20170028128A KR 20180101767 A KR20180101767 A KR 20180101767A
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catheter
zinc oxide
central venous
present
composition
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김도연
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김도연
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L29/126—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/02—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0009—Making of catheters or other medical or surgical tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06—Body-piercing guide needles or the like
    • A61M25/0606—"Over-the-needle" catheter assemblies, e.g. I.V. catheters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/20—Oxides; Hydroxides
    • C08K3/22—Oxides; Hydroxides of metals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
    • C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
    • C08L75/04—Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L81/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing sulfur with or without nitrogen, oxygen or carbon only; Compositions of polysulfones; Compositions of derivatives of such polymers
    • C08L81/06—Polysulfones; Polyethersulfones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
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Abstract

The present invention relates to a composition for catheters, a central venous catheter produced by using the same, and an intravascular tube catheter. The composition includes a mixture obtained by mixing polyvinylpyrrolidone and zinc oxide along with at least one selected from the group consisting of silicone, polyurethane and polysulfone. According to the present invention, it is possible to secure excellent antithrombotic abilities and antibacterial functions.

Description

카테터용 조성물, 그를 이용하여 제조된 중심 정맥 카테터 및 혈관 내 튜브 카테터 {The composition for catheter, the central venous catheter and the intravascular tube catheter prepared by using the same}BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a composition for a catheter, a central venous catheter manufactured using the same, and a vascular endotracheal catheter,

본 발명은 카테터용 조성물과, 해당 조성물을 이용하여 제조되는 중심 정맥 카테터 및 혈관 내 튜브 카테터에 관한 것이다.The present invention relates to a catheter composition and a central venous catheter and an intravascular tube catheter manufactured using the composition.

카테터(catheter)는 질병을 치료하거나 수술할 목적으로 인체에 삽입하는 도관으로써, 의료용 소재를 압출 성형하여 만든 것이다. 카테터는 심혈관계, 비뇨기계, 소화기계 등 다양한 임상 분야에서 응용되므로 인체의 강, 관, 혈관 등에 삽입된다. 특히, 카테터는 허혈성 심혈관계 질병을 진단 또는 치료하거나, 가이드용 도관 및 풍선 카테터를 이용하여 관상동맥을 확장하는 경피적 관상동맥 확장술 등에 많이 적용되고 있다.A catheter is a catheter that is inserted into a human body for the purpose of curing or surgery, and is made by extruding a medical material. Since the catheter is applied in various clinical fields such as cardiovascular, urinary and digestive apparatuses, it is inserted into the human body such as steel, tube, and blood vessel. Particularly, catheter is widely used for diagnosis or treatment of ischemic cardiovascular diseases, percutaneous coronary artery dilatation for expanding coronary artery using guide catheter and balloon catheter.

혈관 내 카테터를 사용하는 경우, 카테터 주위에 혈관 내에서 생성된 혈전 또는 박테리아가 들러붙어서 감염을 유발하는 문제점도 존재한다.In the case of using an intravascular catheter, there is also a problem that the thrombus or bacteria generated in the blood vessel around the catheter sticks to cause infection.

이처럼, 기존의 카테터는 항혈전력 및 항균력이 우수하지 못하여 감염의 위험성이 존재하므로 보다 우수한 항혈전력 및 항균력을 가지는 혈관 내 튜브 카테터용 조성물 및 그를 포함하는 혈관 내 튜브 카테터가 필요한 실정이다.As such, existing catheters have a high risk of infection due to poor antibiotic power and antibacterial ability. Therefore, there is a need for a composition for intravascular tube catheter having better antimicrobial power and antimicrobial activity and an intravascular tube catheter containing the same.

본 발명은 보다 우수한 항혈전력 및 항균력을 가지는 카테터용 조성물과, 그를 포함하는 중심 정맥 카테터 및 혈관 내 튜브 카테터를 제공하는데 그 목적이 있다.It is an object of the present invention to provide a composition for a catheter having better anticoagulant power and antimicrobial power, and a central venous catheter and an endovascular tube catheter comprising the same.

상기 목적을 달성하기 위하여, 본 발명의 일 실시예에 따른 카테터용 조성물은 실리콘(silicone), 폴리우레탄(polyurethane) 및 폴리설폰(polysulfone)으로 이루어진 군으로부터 선택되는 1종 이상에 폴리비닐피롤리돈(polyvinylpyrrolidone) 및 징크옥사이드(Zinc Oxide)가 혼합되어 구성되는 것을 포함한다.In order to achieve the above object, the composition for a catheter according to an embodiment of the present invention may comprise at least one selected from the group consisting of silicone, polyurethane and polysulfone, polyvinylpyrrolidone (polyvinylpyrrolidone) and zinc oxide (zinc oxide).

또한, 본 발명에 따른 상기 폴리비닐비롤리돈은 상기 징크옥사이드 분자를 감싸, 상기 징크옥사이드의 분산을 균일하게 하는 것을 특징으로 한다.In addition, the polyvinyl birolidone according to the present invention is characterized in that the zinc oxide molecules are wrapped to uniformly disperse the zinc oxide.

그리고, 본 발명의 일 실시예에 따른 중심 정맥 카테터는 실리콘(silicone), 폴리우레탄(polyurethane) 및 폴리설폰(polysulfone)으로 이루어진 군으로부터 선택되는 1종 이상에 폴리비닐피롤리돈(polyvinylpyrrolidone) 및 징크옥사이드(Zinc Oxide)가 혼합되어 구성된 조성물을 이용하여 제조되는 것을 포함한다.In addition, the central venous catheter according to an embodiment of the present invention may include at least one selected from the group consisting of silicone, polyurethane, and polysulfone, polyvinylpyrrolidone, (Zinc Oxide) are mixed with each other.

또한, 본 발명에 따른 상기 폴리비닐피롤리돈은 상기 징크옥사이드 분자를 감싸, 상기 징크옥사이드의 분산을 균일하게 하는 것을 특징으로 한다.In addition, the polyvinylpyrrolidone according to the present invention is characterized in that the zinc oxide molecule is surrounded to uniformly disperse the zinc oxide.

또한, 본 발명의 일 실시예에 따른 혈관 내 튜브 카테터는 실리콘(silicone), 폴리우레탄(polyurethane) 및 폴리설폰(polysulfone)으로 이루어진 군으로부터 선택되는 1종 이상에 폴리비닐피롤리돈(polyvinylpyrrolidone) 및 징크옥사이드(Zinc Oxide)가 혼합되어 구성된 조성물을 이용하여 제조되는 것을 포함한다.In addition, the endovascular tube catheter according to an embodiment of the present invention may include polyvinylpyrrolidone and / or polyvinylpyrrolidone in at least one selected from the group consisting of silicone, polyurethane, and polysulfone, And zinc oxide (Zinc Oxide).

또한, 본 발명에 따른 상기 폴리비닐피롤리돈은 상기 징크옥사이드 분자를 감싸, 상기 징크옥사이드의 분산을 균일하게 하는 것을 특징으로 한다.In addition, the polyvinylpyrrolidone according to the present invention is characterized in that the zinc oxide molecule is surrounded to uniformly disperse the zinc oxide.

본 발명에 따라 실리콘(silicon), 폴리우레탄(polyurethane) 및 폴리설폰(polysulfone) 중 적어도 1가지 물질, PVP(Polyvinylpyrrolidone) 및 징크옥사이드가 혼합된 카테터용 조성물을 제공할 수 있으며, 이를 포함함으로써 보다 우수한 항혈전력 및 항균력을 가지는 중심 정맥 카테터 또는 혈관 내 튜브 카테터를 제공 가능한 효과가 있다.According to the present invention, it is possible to provide a composition for a catheter in which at least one of silicon, polyurethane and polysulfone, polyvinylpyrrolidone (PVP) and zinc oxide is mixed, It is possible to provide a central venous catheter or an endovascular tube catheter having an antimicrobial power and an antimicrobial power.

도 1은 본 발명의 일 실시예에 따른 중심 정맥 카테터를 나타낸 것이다. 1 shows a central venous catheter according to an embodiment of the present invention.

이하 본 발명의 바람직한 실시를 보다 상세하게 설명한다. 그러나 본 발명은 다수의 상이한 형태로 구현될 수 있고, 기술된 실시예에 제한되지 않음을 이해하여야 한다. 하기에 설명되는 본 발명의 실시예는 당업자에게 본 발명의 사상을 충분하게 전달하기 위한 것임에 유의하여야 한다.Hereinafter, preferred embodiments of the present invention will be described in detail. It should be understood, however, that the invention can be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. It should be noted that the embodiments of the present invention described below are intended to sufficiently convey the spirit of the present invention to those skilled in the art.

상기 목적을 달성하기 위하여, 본 발명의 일 실시예에 따른 중심정맥카테터용 조성물은 실리콘(silicone), 폴리우레탄(polyurethane) 및 폴리설폰(polysulfone)으로 이루어진 군으로부터 선택되는 1종 이상에 폴리비닐피롤리돈(polyvinylpyrrolidone) 및 징크옥사이드(Zinc Oxide)가 혼합되어 구성된 것일 수 있다.In order to achieve the above object, a composition for a central venous catheter according to an embodiment of the present invention comprises at least one selected from the group consisting of silicone, polyurethane, and polysulfone, (Polyvinylpyrrolidone) and zinc oxide (zinc oxide).

또한, 본 발명에 따른 상기 폴리비닐비롤리돈은 상기 징크옥사이드 분자를 감싸, 상기 징크옥사이드의 분산을 균일하게 하는 것을 특징으로 할 수 있다.In addition, the polyvinyl birolidone according to the present invention may be characterized in that the zinc oxide molecules are wrapped to uniformly disperse the zinc oxide.

그리고, 본 발명의 일 실시예에 따른 중심정맥카테터는 실리콘(silicone), 폴리우레탄(polyurethane) 및 폴리설폰(polysulfone)으로 이루어진 군으로부터 선택되는 1종 이상에 폴리비닐피롤리돈(polyvinylpyrrolidone) 및 징크옥사이드(Zinc Oxide)가 혼합되어 구성된 조성물을 이용하여 제조되는 것을 포함할 수 있다.In addition, the central venous catheter according to an embodiment of the present invention may include at least one selected from the group consisting of silicone, polyurethane, and polysulfone, polyvinylpyrrolidone, (Zinc Oxide) are mixed with each other.

또한, 본 발명에 따른 상기 폴리비닐피롤리돈은 상기 징크옥사이드 분자를 감싸, 상기 징크옥사이드의 분산을 균일하게 하는 것을 특징으로 할 수 있다.In addition, the polyvinylpyrrolidone according to the present invention may be characterized in that the zinc oxide molecules are wrapped to uniformly disperse the zinc oxide.

도 1은 본 발명의 일 실시예에 따른 중심정맥카테터를 나타내는 것이다.1 shows a central venous catheter according to an embodiment of the present invention.

본 발명의 일 실시예에 따른 중심정맥카테터(10)는 일정한 길이를 가지는 튜브 형상일 수 있다. 또한, 중심정맥카테터(10)는 환자의 혈관 내로 삽입될 때, 환자의 혈관을 손상시키지 않을 수 있다.The central venous catheter 10 according to an embodiment of the present invention may be in the form of a tube having a certain length. Further, when the central venous catheter 10 is inserted into a patient's blood vessel, it may not damage the patient's blood vessel.

이 때, 필요에 따라, 환자의 혈관 내로 삽입된 중심정맥카테터(10)에 다양한 의료 기구들이 삽입되는 것을 가능하게 하여, 환자의 치료에 필요한 시술이 가능하도록 할 수 있다.At this time, it is possible to insert various medical instruments into the central venous catheter 10 inserted into the blood vessel of the patient, if necessary, so that the procedure necessary for the treatment of the patient can be made possible.

또한, 본 발명의 일 실시예에 따른 중심정맥카테터(10)는 복수 개의 구멍을 가질 수 있다. 상기 복수 개의 구멍을 통하여 환자에게 혈관조영술 등 각종 시술에 필요한 약제를 투입하거나 환자의 치료를 위한 기타 약물 등을 투입하는 경우, 투입된 약제 또는 약물이 빠르게 혈액으로 전달되어 환자에게 약제 또는 약물을 보다 효율적으로 투여할 수 있다.In addition, the central venous catheter 10 according to an embodiment of the present invention may have a plurality of holes. When the medicines necessary for various procedures such as angiography or the like are put into the patient through the plurality of holes or other medicines for treating the patient are put in, the injected medicines or medicines are rapidly delivered to the blood and the medicines or medicines are more efficiently ≪ / RTI >

본 발명의 일 실시예에 따른 중심정맥카테터(10)는 실리콘(silicone), 폴리우레탄(polyurethane) 및 폴리설폰(polysulfone)으로 이루어진 군으로부터 선택되는 1종 이상에 폴리비닐피롤리돈(polyvinylpyrrolidone) 및 징크옥사이드(Zinc Oxide)가 혼합되어 구성된 조성물을 이용하여 제조될 수 있다.The central venous catheter 10 according to an embodiment of the present invention may be made of at least one selected from the group consisting of silicone, polyurethane and polysulfone, polyvinylpyrrolidone, And zinc oxide (Zinc oxide).

폴리비닐피롤리돈(PVP, Polyvinylpyrrolidone)은 의약품 중 포비돈-요오드의 주요 원료로 사용되며, 화학적으로 안정적인 제품으로써, 화합물을 제조할 때 안정제 또는 분산제로 사용된다.Polyvinylpyrrolidone (PVP) is used as a major raw material for povidone-iodine in pharmaceuticals. It is chemically stable and is used as a stabilizer or dispersant in the preparation of compounds.

징크옥사이드(Zinc Oxide)는 나노 입자 크기가 항균력에 영향을 미치며, 나노 입자의 크기가 작을수록 강한 항균력을 가진다. 또한, 생성된 혈전에서 주로 발생하는 박테리아에 의한 감염을 억제하는 것이 가능하다.Zinc oxide has a strong antibacterial activity as nanoparticle size affects the antimicrobial activity and smaller nanoparticle size. It is also possible to inhibit the infection caused by the bacteria mainly occurring in the generated thrombus.

이에 따라, 본 발명의 일 실시예에 따른 중심정맥카테터용 조성물은 보다 우수한 항혈전력 및 항균력을 가질 수 있다.Accordingly, the composition for a central venous catheter according to one embodiment of the present invention can have better antimicrobial power and antimicrobial activity.

또한, 폴리비닐피롤리돈(PVP)은 원자 구조 상 그물 형태로 징크옥사이드 분자를 감쌀 수 있고, 이로 인해 폴리우레탄의 단위 면적당 징크옥사이드의 분산을 균일하게 할 수 있다.In addition, polyvinylpyrrolidone (PVP) can envelop the zinc oxide molecule in the form of a net in atomic structure, thereby making it possible to uniformly disperse zinc oxide per unit area of the polyurethane.

이로부터 징크옥사이드가 중심 정맥 카테터(10)에 균일하게 존재할 수 있게 되어 본 발명의 일 실시예에 따른 중심 정맥 카테터(10)가 박테리아 감염에 대하여 동일한 항균력을 가지도록 할 수 있다.From this, zinc oxide can be uniformly present in the central venous catheter 10, so that the central venous catheter 10 according to one embodiment of the present invention can have the same antibacterial activity against bacterial infection.

이 때, 중심정맥카테터용 조성물 간의 배합 비율은 중심정맥카테터(10)의 기능성에 따라 변동 가능하다.At this time, the mixing ratio between the compositions for the central venous catheter may vary depending on the functionality of the central venous catheter 10.

그리고, 본 발명의 일 실시예에 따른 중심정맥카테터용 조성물은 일반적인 중심정맥카테터 뿐만 아니라, 인체 내에 삽입될 수 있는 각종 도관, 예를 들어 정맥 카테터, 액체저류용 도관, 두개내압 측정용 카테터, 경막, 지주막하강 및 완신경총 카테터, 기관용 튜브, 약물 투여용 도관, 자궁 내 카테터 등에 광범위하게 적용이 가능하다.In addition, the composition for a central venous catheter according to an embodiment of the present invention may be used not only in a general central venous catheter but also in various types of catheters that can be inserted into a human body, such as an intravenous catheter, a liquid storage catheter, , Subarachnoid and subarachnoid catheters, tracheal tubes, drug delivery catheters, intrauterine catheters, and the like.

예를 들어, 본 발명의 일 실시예에 따른 혈관 내 튜브 카테터는 실리콘(silicone), 폴리우레탄(polyurethane) 및 폴리설폰(polysulfone)으로 이루어진 군으로부터 선택되는 1종 이상에 폴리비닐피롤리돈(polyvinylpyrrolidone) 및 징크옥사이드(Zinc Oxide)가 혼합되어 구성된 조성물을 이용하여 제조될 수 있다.For example, an endovascular tube catheter according to an embodiment of the present invention may be provided with at least one member selected from the group consisting of silicone, polyurethane, and polysulfone, polyvinylpyrrolidone ) And zinc oxide (Zinc Oxide).

또한, 상기한 바와 같은 조성물은 PICC(peripheral inserted central catheter) 또는 central veouns catheter port(Port)에 사용될 수도 있다.The composition as described above may also be used in a peripheral inserted central catheter (PICC) or a central vein catheter port (Port).

이와 같이, 상술한 본 발명의 기술적 구성은 본 발명이 속하는 기술분야의 당업자가 본 발명의 그 기술적 사상이나 필수적 특징을 변경하지 않고서 다른 구체적인 형태로 실시될 수 있다는 것을 이해할 수 있을 것이다.As described above, it is to be understood that the technical structure of the present invention can be embodied in other specific forms without departing from the spirit and essential characteristics of the present invention.

그러므로 이상에서 기술한 실시예들은 모든 면에서 예시적인 것이며 한정적인 것이 아닌 것으로서 이해되어야 하고, 본 발명의 범위는 전술한 상세한 설명보다는 후술하는 청구범위에 의하여 나타내어지며, 청구범위의 의미 및 범위 그리고 그 등가개념으로부터 도출되는 모든 변경 또는 변형된 형태가 본 발명의 범위에 포함되는 것으로 해석되어야 한다.Therefore, it should be understood that the above-described embodiments are to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, All changes or modifications that come within the scope of the equivalent concept are to be construed as being included within the scope of the present invention.

Claims (6)

실리콘(silicone), 폴리우레탄(polyurethane) 및 폴리설폰(polysulfone)으로 이루어진 군으로부터 선택되는 1종 이상에 폴리비닐피롤리돈(polyvinylpyrrolidone) 및 징크옥사이드(Zinc Oxide)가 혼합되어 구성되는
중심 정맥 카테터용 조성물.(Polyvinylpyrrolidone) and zinc oxide (Zinc Oxide) is mixed with at least one member selected from the group consisting of silicone, polyurethane, and polysulfone
A composition for a central venous catheter. 제1항에 있어서,
상기 폴리비닐비롤리돈은
상기 징크옥사이드 분자를 감싸, 상기 징크옥사이드의 분산을 균일하게 하는 것을 특징으로 하는
중심 정맥 카테터용 조성물.The method according to claim 1,
The polyvinyl birolidone
Characterized in that the zinc oxide molecules are wrapped to uniformly disperse the zinc oxide
A composition for a central venous catheter. 실리콘(silicone), 폴리우레탄(polyurethane) 및 폴리설폰(polysulfone)으로 이루어진 군으로부터 선택되는 1종 이상에 폴리비닐피롤리돈(polyvinylpyrrolidone) 및 징크옥사이드(Zinc Oxide)가 혼합되어 구성된 조성물을 이용하여 제조되는
중심 정맥 카테터.Wherein at least one selected from the group consisting of silicone, polyurethane and polysulfone is mixed with polyvinylpyrrolidone and zinc oxide, felled
Central venous catheter. 제3항에 있어서,
상기 폴리비닐피롤리돈은
상기 징크옥사이드 분자를 감싸, 상기 징크옥사이드의 분산을 균일하게 하는 것을 특징으로 하는 중심 정맥 카테터.The method of claim 3,
The polyvinyl pyrrolidone
Wherein the zinc oxide molecule is wrapped around the zinc oxide to uniformly disperse the zinc oxide. 실리콘(silicone), 폴리우레탄(polyurethane) 및 폴리설폰(polysulfone)으로 이루어진 군으로부터 선택되는 1종 이상에 폴리비닐피롤리돈(polyvinylpyrrolidone) 및 징크옥사이드(Zinc Oxide)가 혼합되어 구성된 조성물을 이용하여 제조되는
혈관 내 튜브 카테터.Wherein at least one selected from the group consisting of silicone, polyurethane and polysulfone is mixed with polyvinylpyrrolidone and zinc oxide, felled
Intravascular tube catheter. 제5항에 있어서,
상기 폴리비닐피롤리돈은
상기 징크옥사이드 분자를 감싸, 상기 징크옥사이드의 분산을 균일하게 하는 것을 특징으로 하는 혈관 내 튜브 카테터.


6. The method of claim 5,
The polyvinyl pyrrolidone
Wherein the zinc oxide molecule is wrapped around the zinc oxide to disperse the zinc oxide uniformly.


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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210059103A (en) 2019-11-14 2021-05-25 주식회사 바스플렉스 Resin composition for catheter inner tube and inner tube using same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210059103A (en) 2019-11-14 2021-05-25 주식회사 바스플렉스 Resin composition for catheter inner tube and inner tube using same

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