KR20170028383A - Rna 전사물 변이체의 정량분석을 위한 방법 및 생성물 - Google Patents
Rna 전사물 변이체의 정량분석을 위한 방법 및 생성물 Download PDFInfo
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Abstract
본 발명은 전사체학의 분야에 관한 것이며, 전사물 변이체를 모방하는 인공 폴리핵산 분자의 참조 세트를 제공하고 상기 참조 세트를 외부 대조용으로서 전사물 변이체를 포함하는 샘플에 가함을 포함하는, 샘플 중 전사물 변이체의 조절된 식별 및/또는 정량분석 방법을 제공한다. 본 발명은 또한 상기와 같은 참조 세트뿐만 아니라 상기와 같은 참조 세트의 제조 방법을 제공한다.
Description
본 발명은 전사체학, 특히 전체 전사체 샷건 서열분석("RNA-seq") 분야에 관한 것이다. 보다 구체적으로, 본 발명은 RNA-seq 또는 마이크로-어레이 분석 또는 정량적인 PCR(qPCR)에 의해 분석된 샘플 중 RNA 전사물 변이체의 식별 및 정량분석에 적합한 방법 및 생성물에 관한 것이다.
차세대 서열분석(NGS) 기술은 핵산 샘플의 서열분석시 다량의 짧은 리드(read)를 생성시킨다. 차세대 서열분석의 필수 단계는 라이브러리 제조 또는 간략히 라이브러리 프렙(prep)이다. 상기 과정은 mRNA 또는 cDNA를 투입으로서 취하여, 각각 mRNA 분자의 섹션에 상응하는 짧은 cDNA 단편들의 라이브러리를 생성시킨다. 이어서 상기 단편을 NGS 서열분석기에 의해, 대개는 상기 단편 전체가 아니라 부분적으로 그의 개시 및/또는 단부에서 서열분석한다. 그 결과 리드라 칭하는 뉴클레오티드의 짧은 서열들이 생성되며 이들은 가장 통상적으로는 4개의 ASCII 문자, 예를 들어 A, C, G, T 또는 0, 1, 2, 3(유전 암호의 핵염기를 나타낸다) 그룹의 서열로서 상기 NGS 서열분석기에 의해 저장된다. mRNA 분자가 원래의 샘플 중에 존재하였음을 추단하기 위해서, 상기 리드를 참조 게놈(reference genome) 또는 전사체상에 지도화(mapping)하거나 또는 정렬시키거나, 또는 서열 오버랩을 근거로 드노보 조립한다.
차세대 서열분석은 다양한 게놈 지도화 과정(US 2013/110410 A1) 또는 DNA 식별 방법에, 예를 들어 지도화된 게놈을 사용하여 서열 리드를 몇몇 유기체 변이체에 관련시킴으로써(WO 2009/085412 A1) 사용되어 왔다.
WO 2009/091798 A1은 유기체 전사체의 프로파일을 획득하는 방법을 기재하며, 상기 방법은 하나 이상의 cDNA 분자를 서열분석하여 서열분석 리드들을 획득하고; 각각의 상기 서열분석 리드를 참조 서열에 대해 정렬시킴을 포함한다.
그러나, 짧은 서열 리드를 사용하는 전사체 분석에 근원하는 주요 문제는 하기의 단락들에 기재된 바와 같은 전사물 변이체 경우의 정렬 단계이다. 짧은 서열 리드를 하나의 전사물 변이체에 정확하게 정렬시키고 특히 샘플 중에 존재하는 모든 전사물 변이체를 신뢰성 있게 정량분석하는 것은 대개 어렵다.
EP 2 333 104 A1은 잠재적으로 다양한 RNA 분자들의 풀로부터 유래된 핵산 분자 단편 서열의 RNA 분석학적 배열 방법에 관한 것이다. 유전자는 하나의 전사물 변이체에서 발현될 뿐만 아니라 다수의 전사물 동형(isoform)들이 주어진 게놈 영역으로부터, 그들의 엑손-인트론 조성 및 전사 개시-(TSS) 및 종료-부위(TES)의 변화와 함께 전사될 수 있다(예를 들어 Nilsen and Graveley, 2010; Wang et al., 2009; Koscielny et al., 2009을 참조하시오). 전사물 동형들은 또한 여섯 자릿수(106 배)까지 그들의 풍부성이 다양할 수 있으며, 이는 추가적인 복잡성을 한 층 더 가중시킬 수 있다(Aird et al., 2013). 장(Zhang) 등은 합성적인 선택적 스플라이싱 데이터베이스에 관한 것이다.
RNA-Seq에 의한 상기 전사체의 복잡성 분석은 짧은 리드를 어노테이션된(annotated) 참조 게놈에 정렬시키고 전사물 유사체 및 가설을 특유의 특징, 예를 들어 콘틱 커버리지(contig coverage)로부터 찾아 엑손-엑손 접합을 증명함을 필요로 한다(예를 들어 Wang et al., 2009를 참조하시오). 이러한 연산(algorithms)은 불충분하고 상이하게 관장된 어노테이션, 및 유사한 특징을 공유하고 유사한 수준으로 발현되는 전사물 변이체를 식별하는 본질적인 문제로 인해 결코 정확하지 않다. 게놈 서열 및 어노테이션을 사용하지 않는 전사체 드노보 조립(transcriptome de novo assembly)은 훨씬 더 어려우며 비효율적이고 대개는 충분히 특성화되지 않은 유기체에 적용된다.
본 발명의 목적은 샘플 중 전사물 변이체의 보다 정확한 평가(즉 식별 및 정량분석)를 허용하는 방법 및 생성물을 제공하는 것이다.
본 발명은
a) 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 특히 적어도 5개의 상이한 핵산 (NA) 분자 그룹을 포함하고, 이때 각각의 그룹이 적어도 2개, 바람직하게는 적어도 3개, 보다 바람직하게는 적어도 4개, 특히 적어도 5개의 상이한 NA 분자로 이루어지는, 전사물 변이체를 모방하는(simulating) 인공 NA 분자의 참조 세트를 제공하고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 모든 NA 분자는 동일한 인공 유전자의 참조 전사물 변이체이고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 NA 분자는 적어도 80 뉴클레오티드(nt) 길이, 바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 특히 적어도 200 nt의 서열을 공유하고, 상기 각 그룹의 적어도 2개의 NA 분자는 적어도 80 nt 길이, 바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 훨씬 더 바람직하게는 적어도 200 nt, 특히 적어도 300 nt의 적어도 또 다른 서열만큼 상이하며,
여기에서 상기 NA 분자의 적어도 2개, 바람직하게는 각각은 소정의 몰량으로 존재하는 단계; 및
b) 상기 참조 세트를 외부 대조용으로서 상기 전사물 변이체를 포함하는 하나 이상의 샘플에 가하는 단계; 및
c1) NA 서열분석을 리드 생성(read generation) 및 할당(assignment)을 근거로 수행하고, 여기에서 참조 리드 할당은 상기 참조 세트의 리드에 의해 생성되고 상기 참조 리드 할당을 사용하여 상기 하나 이상의 샘플의 전사물 변이체의 리드 할당을 조절, 확인 또는 변형시키는 단계; 또는
c2) NA 검출 또는 정량분석 방법, 바람직하게는 마이크로-어레이 분석 또는 qPCR을 상기 하나 이상의 샘플상에서 수행하고, 여기에서 적어도 하나의 탐침이 상기 참조 세트의 적어도 하나의 NA 분자에 결합하며 상기 참조 세트의 적어도 하나의 NA 분자에 결합하는 적어도 하나의 탐침으로부터 생성되는 신호에 기반한 측정 결과를 사용하여 상기 NA 검출 또는 정량분석 방법에서 탐침에 결합하는 상기 하나 이상의 샘플의 전사물 변이체로부터 생성되는 신호에 기반한 측정 결과를 조절, 확인 또는 변형시키는 단계
를 포함하는, 하나 이상의 샘플 중 전사물 변이체의 조절된 식별 및/또는 정량분석 방법을 제공한다.
본 발명은 또한 상기 방법에 사용하기에 매우 적합한 인공 NA 분자의 참조 세트뿐만 아니라, 상기와 같은 참조 세트 및 상기와 같은 참조 세트 중에 함유하기에 적합한 NA 분자를 생성시키는 방법을 제공한다.
하기의 상세한 설명 및 바람직한 실시태양을 본 발명의 모든 태양에 적용하며, 명백히 지시되는 경우를 제외하고, 제한 없이 서로 조합할 수 있다. 바람직한 실시태양 및 태양을 특허청구범위에서 추가로 정의한다.
내부, 외부, 상대적 및 절대적 표준은 전사물 변이체(진핵생물 세포로부터의 거의 모든 전사물 샘플에 적용된다)를 포함하는 샘플의 상이한 정성적 지표를 측정하고 상기와 같은 복잡한 전사물 샘플을 분석하고자 하는 방법에 필수적이다. 정량적 데이터를 상대적인 또는 절대적인 용어로 나타낼 수 있다. 각각의 다양한 방법, 예를 들어 마이크로-어레이, qPCR 또는 NGS는 측정 결과의 표준화에 관하여 상기 데이터 분석에서 다수의 특수성을 갖는다.
마이크로-어레이 및 qPCR에서의 상대적인 정량분석을 위해서 RNA 수준을 내부 또는 외부 대조용을 사용하여 샘플들간에 비교하여 샘플 농도 및 부하에서의 차이를 표준화한다. NGS 실험은 리드의 수, 및 식별된 전사물의 길이에 대해 상이한 표준화 과정을 사용한다. 상기 결과는 유전자 어노테이션의 품질 및 상태와 같은 다수의 변수, 또는 상기 정렬 및 조립 연산에 의한 라이브러리 제조와 서열분석 편향간의 일치에 따라 변한다. 예를 들어 상기 라이브러리 제조 효율에서의 차이를 보상하기 위한 대조군이 필요하다.
대조군은 상기 샘플 세트 전체 걸쳐 일정한 수준으로 발현되는 유전자(내부 참조) 또는 스파이크-인(spike-in))되는 RNA(외부 참조)이다. 정량분석의 경우 상기 실험 유전자, 엑손 또는 태그의 발현 수준을 나타내는 신호 강도(형광 단위 또는 리드 수)는 기지의 양 또는 비를 함유하는 표준과 관련되며 절대적인 또는 상대적인 참조로서 정의되었다.
상기 US 2004/009512 A1은 내부 대조용 탐침을 사용하여 mRNA 스플라이싱 생성물을 분석하는 방법을 개시한다(청구항 7, 상기 문서의 [0097] 및 [0106]의 단락). 본 발명과 관련된 분자의 길이를 갖는 변이체를 나타내는 내부 대조군에 관한 개시는 없다.
다수의 복잡한 RNA 표준 샘플, 예를 들어 보편적인 인간 참조 RNA 및 보편적인 인간 뇌 참조 RNA(앰비온(Ambion), 라이프 테크놀로지스(Life Technologies))를 상업적으로 입수할 수 있다. 상기 표준을 다수의 공여자 및 다수의 조직/뇌 영역으로부터 모으며(pooled), 따라서 상기 표준은 광범위하게 편향되지 않고 재현 가능한 유전자 발현 커버리지를 목표로 한다. 상기와 같은 표준 샘플상에서의 실험은 참조 데이터를 제공하며 실험 방법을 입증하고 평가하는데 사용된다. 미지의 샘플에 대한 측정을 서로 및 상기 표준 샘플에 대해 연동시키기 위해서 내부 또는 외부 표준이 필요하다.
내부 RNA 표준은 분석되는 샘플 전체에 걸쳐 비교적 일정한 수준으로 발현되는 유전자이다. 내부 표준은 유기체의 상이한 조직들에서, 모든 발생 단계에서, 및 대조용 및 실험적으로 처리된 세포 유형에 대해 균등하게 발현되어야 하며, 이를 종종 "하우스키핑" 유전자라 칭한다. 불행하게도, 18S rRNA가 가장 광범위한 실험 조건하에서 이상적인 내부 대조군에 가까운 것으로 보이지만, 상기 모든 상황에서 일정한 발현 수준을 갖는 단일 RNA는 존재하지 않는다. 그러나, rRNA의 비교적 높은 풍부성은 rRNA를 자유로운 서열분석 공간으로 특이적으로 소모시키는 라이브러리 제조 방법을 도출한다.
따라서, 특정한 실험 문제에 대해서 가장 있음직한 mRNA가 되는 적합한 대조용 RNA를 식별할 필요가 있다. 이는 차례로 상기 표준의 적합성에 대한 mRNA 동형들의 영향을 고려할 필요가 있다. 일부 내부 표준을 찾을 수 있지만(β-액틴, 글리세르알데히드-3-포스페이트-데하이드로게나제(GAPDH), 또는 사이클로필린 mRNA), 오직 외부 표준만이 조절되고 신뢰성 있는 참조 값을 제공한다. 다른 종의 RNA 샘플로부터의 일정한 공급원, 예를 들어 포유동물 샘플에 첨가된 세균 전사체를 외부 표준으로서 사용할 수 있었다. 그러나, 원핵생물처럼 훨씬 더 단순한 유기체들이 이미 상기와 같은 높은 전사물 수를 갖기 때문에, 전체 동적(농도) 범위 전체를 통해 균형잡힌 표시는 너무 많은 서열분석 공간을 낭비할 것이다. 따라서, 복잡성은 낮지만 필적하는 동적 범위를 갖는 외부 표준, ERCC가 앞서 개발되었다.
국립 표준기술 연구소(NIST, USA)에 의해 선도되고 37개 연구소로 이루어지는 ERCC 협회는 함께 합성 DNA 서열, 또는 바실러스 서브틸리스(Bacillus subtilis) 또는 심해 배출 미생물 메타노칼도코커스 자나쉬이(Methanocaldococcus jannaschii) 게놈으로부터 유래된 DNA의 시험관내 전사에 의해 대조용 RNA를 합성하였다. 상기 전사물은 모노엑손이고 비-동형성으로 되어 있다, 즉 상기는 스플라이싱 또는 다른 전사물 변이체를 나타내지 않는다. 상기 협회는 19 내지 25 아데닌(중간 23 아데노신)의 폴리-A 꼬리 길이, 250 내지 2000 nt의 길이 및 ∼30 내지 55%의 GC-함량을 결정하였다. 상기 다양한 서열은 내인성 전사물의 성질들 중 적어도 일부, 예를 들어 GC 함량 및 길이의 다양성을 나타낸다. ERCC RNA는 서열분석된 진핵생물로부터의 내인성 전사물과 최소의 서열 상동성을 나타낸다(External RNA Controls Consortium, 2005a). 상기 ERCC 믹스 개발이 특별 보고서(External RNA Controls Consortium, 2005)에 기록되어 있다.
블롬퀴스트(Blomquist) 등은 NGS에 의한 DNA 서열분석에 관한 것이며 합성 내부 표준을 사용하는 방법을 사용한다(상기 문서의 초록 및 도 1). RNA 가공 중에, ERCC 스파이크-인 대조용 내부 표준이 사용된다(상기 문서의 p.4, 좌측 컬럼). 데븐셔(Devonshire) 등이 또한 상기 ERCC에 관한 것이다.
앰비온(라이프 테크놀로지스의 파트)은 상업적으로, 자립형(stand-alone) 믹스(106배에 걸친 농도) 또는 차별적인 유전자 발현을 위해 비교해야 하는(변화 배수 측정의 정확도를 측정하는; 사용자 지침: ERCC RNA Spike-In Control Mixes, Ambion) 2개 샘플에 스파이크되도록 설계된 2개의 믹스로 92개 ERCC 전사물을 제공한다.
상기는 처음에 qPCR 및 마이크로-어레이 시스템에 사용되는 것으로 고안되었지만, 현재는 RNA-Seq NGS 실험에 널리 사용되고 있다. 상기 상이한 의도적인 목적은 ERCC의 현행 용도를 의심스럽게 만든다.
상기 ERCC의 한계는 i) 그의 크기 범위가 제한되고, ii) 오직 짧은 폴리-A-꼬리만을 함유하며, iii) 캡-구조가 없다는 것이다. 그러나, 상기 ERCC의 주요 단점은 상기가 어떠한 종류의 전사물 변이체도 함유하지 않는다는 것이다. 따라서, 상기는 이 점에 있어서 전사물 변이체의 조절된 식별 및/또는 정량분석 및 서열분석 방법(또는 다른 분석 방법)의 평가에 적합하지 않다. 또 다른 단점은 상기가 공지된 서열(바실러스 및 메타노코커스)과 유사성을 갖는다는 것이다.
선(Sun) 등은 선택적으로 스플라이싱된 전사물의 정량분석에 관한 것이다. 인간 텔로머라제 역전사효소의 스플라이싱 변이체가 대조용으로서 사용된다. 대략 20개의 스플라이싱 변이체가 공지되어 있으며, 이중 4개는 종양에 통상적이다(상기 문서의 p. 319, 중간 컬럼). 상기 통상적인 4개는 상기 문서에서 조사되었다(p.320 중간 컬럼, 및 도 1; p. 321, 좌측 컬럼; 상기 문서의 표 1). 그러나, 상기 문서는 인공 전사물 변이체에 관한 것이 아니며, 상기 문서의 대조군은, 천연 서열에 의존할 필요 없이(천연 서열에 대한 의존은 실제로 상기 실험을 방해할 수 있다) 선택적 스플라이싱 사건의 전형적이고 정확한 모방을 허용하는 본 발명과 달리, 단일 인간 유전자로 제한된다.
본 발명은 특히 이러한 단점들을 극복한다. 본 발명의 과정에서, 다수의 상이한 방법 및 참조 세트들이 전사물 변이체의 식별 및 정량분석의 현행 문제를 해결하기에 특별히 적합한 방법 및 생성물을 찾아내기 위해서 개발되고 특성화되었다.
따라서, 본 발명의 하나의 태양에서,
a) 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 특히 적어도 5개의 상이한 NA 분자 그룹을 포함하고, 이때 각각의 그룹이 적어도 2개, 바람직하게는 적어도 3개, 보다 바람직하게는 적어도 4개, 특히 적어도 5개의 상이한 NA 분자로 이루어지는, 전사물 변이체를 모방하는 인공 핵산(NA) 분자의 참조 세트를 제공하고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 모든 NA 분자는 동일한 인공 유전자의 참조 전사물 변이체이고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 NA 분자는 적어도 80 뉴클레오티드(nt) 길이, 바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 특히 적어도 200 nt의 서열을 공유하고, 상기 각 그룹의 적어도 2개의 NA 분자는 적어도 80 nt 길이, 바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 훨씬 더 바람직하게는 적어도 200 nt, 특히 적어도 300 nt의 적어도 또 다른 서열만큼 상이하며,
여기에서 상기 NA 분자의 적어도 2개, 바람직하게는 각각은 소정의 몰량으로 존재하는 단계(이는 예를 들어 상기 참조(즉 대조용) 리드 할당에 대한 상기 샘플 리드 할당의 표준화를 허용하기 때문에 상기 참조 세트를 본 발명에 특히 적합하게 한다);
b) 상기 참조 세트를 외부 대조용으로서 상기 전사물 변이체를 포함하는 하나 이상의 샘플에 가하는 단계(상기 참조 세트를 동일한 샘플 용기(들) 및/또는 별도의 분석용 용기에 물리적으로 가할 수 있다. 또한, 또는 한편으로, 상기를 또한 동일한 분석 장비, 동일한 분석 장비 모델 또는 다른 분석 장비 모델로부터 상기 참조 세트의 선행 측정을 사용함으로써 컴퓨터-실행되는 방법 단계에 비-물리적으로 가할 수 있다);
c1) NA 서열분석을 리드 생성(상기 리드는 임의의 길이를 가질 수 있다) 및 할당(즉 상기 리드의 참조 서열상으로의 지도화)을 근거로 수행하고, 여기에서 참조 리드 할당은 상기 참조 세트의 리드에 의해 생성되고 상기 참조 리드 할당을 사용하여 상기 하나 이상의 샘플의 전사물 변이체의 리드 할당을 조절, 확인 또는 변형시키는 단계; 또는
c2) NA 검출 또는 정량분석 방법, 바람직하게는 마이크로-어레이 분석 또는 qPCR을 상기 하나 이상의 샘플상에서 수행하고, 여기에서 적어도 하나의 탐침이 상기 참조 세트의 적어도 하나의 NA 분자에 결합하며 상기 참조 세트의 적어도 하나의 NA 분자에 결합하는 적어도 하나의 탐침으로부터 생성되는 신호에 기반한 측정 결과를 사용하여 상기 NA 검출 또는 정량분석 방법에서 탐침에 결합하는 상기 하나 이상의 샘플의 전사물 변이체로부터 생성되는 신호에 기반한 측정 결과를 조절, 확인 또는 변형시키는 단계
를 포함하는, 하나 이상의 샘플 중 전사물 변이체의 조절된 식별 및/또는 정량분석 방법을 제공한다. qPCR에서, 상기 탐침은 PCR 반응에서 연장되는 프라이머 또는 표지된 DNA 탐침일 수 있으며; 마이크로-어레이 분석에서 상기 탐침은 DNA 칩상에 고정화된 DNA 탐침일 수 있다.
상기 NA는 DNA 또는 RNA일 수 있다. 바람직하게, 상기는 RNA이다.
당해 분야의 숙련가는 DNA 또는 RNA로서 상기 참조 세트를 적용해야 할 때 선택에 자유롭다. 숙련가는 또한 NA 서열분석 또는 NA 검출 또는 정량분석 방법을 위해 샘플을 어떻게 제조해야 하는지를 알고 있다. 이롭게는, 상기 참조 세트를, 상기 참조 세트가 모든 또는 대부분의 샘플 제조 단계 중에 존재하도록 NA 서열분석 또는 NA 검출 또는 정량분석 방법을 적용하기 전 샘플 제조 중에 초기에 가한다. 이를 위해서, 바람직하게는 상기를, 상기 전사물 변이체(관심 분자)가 상기 샘플 제조 중 초기에는 전형적으로 mRNA 분자이므로, RNA로서 가한다.
"인공 NA 분자" 또는 "인공 유전자" 또는 "인공 서열"에서와 같은 "인공"이란 용어는 문서 전체를 통해 사용되는 바와 같이, 상기 존재가 천연 생물 유기체(예를 들어 미생물, 동물 또는 식물) 중에 존재하지 않고 인간에 의해 의도적으로 고안되어 생성된 인공물로서 지칭됨을 의미한다. 그러나, 인공 NA 분자 또는 인공 유전자와 같은 인공적인 존재는 여전히 인공적인 그의 특성을 상실하지 않으면서 재조합 유기체에서 생성될 수 있다(예를 들어 천연 이 콜라이 세포내로 도입되어 발현된다).
인공 NA 분자는, 특히 상기가 공지된 NA 서열에 대해 서열 상동성이 없거나 또는 단지 무시할 만한 서열 상동성을 갖는 경우, 본 발명의 방법에 특별히 매우 적합하다. 이는 차세대 서열분석 리드에 전형적인 짧은 서열(예를 들어 40 내지 80 nt 또는 심지어 20 내지 200 nt)의 경우에조차 "참조 리드"로서 리드의 명확한 할당을 허용한다.
일반적으로, 전사물은 전사 개시 부위에서부터 전사 종료 부위에 달하는 RNA 서열로 이루어지는 하나의 유전자로부터(예를 들어 DNA 주형으로부터)의 전사 생성물(예를 들어 RNA 폴리머라제에 의해 합성된)이다. 본 발명의 목적을 위해서, 전사물은 적어도 하나의 엑손을 포함하는 NA 분자이다. 전사물이란 단어는 단일 분자 또는 동일한 서열을 갖는 모든 분자의 그룹을 기술한다. 주지된 바와 같이, 진핵생물에서 mRNA(전사물)는 성숙한 전사물이 되도록 전-mRNA(또한 이종 핵 리보핵산으로서 지칭된다)로부터 가공된다(특히 스플라이싱에 의해). 정의에 따라, 상기 전사물 밖으로 스플라이싱되는 서열 영역을 인트론이라 칭하며, 성숙한 전사물 중에 남아있는 서열 영역을 엑손이라 칭한다. 하나의 성숙한 전사물 변이체에서 엑손은 또 다른 성숙한 전사물 변이체에 대한 인트론일 수 있다(상기 변이체에 존재하지 않음으로 인해). 유전자 서열 영역을, 모든 전사물 변이체의 서열들이 공지된 경우, 엑손 및 인트론으로서 어떻게 어노테이션하는지는 숙련가에게 명백하다. 본 명세서에 사용되는 바와 같이, 엑손은 임의의 변이체에서 엑손일 수 있는 서열 영역이다. 상기는 대개 동봉된 인트론 영역의 양쪽 단부에서 다소 보존된 서열을 통해 특성화되며 이웃하는 엑손과 소위 엑손-엑손 접합을 형성한다(또한 표 2를 참조하시오). 천연 엑손은 암호화 영역의 부분(또는 이와 역)일 수 있으나, 본 발명의 인공 NA 분자의 경우에 상기 엑손은, 본 발명의 인공 서열이 천연으로 존재하는 유기체 중에 존재하는 공지된 전사물과의 유사성이 결여되도록 설계되고 개시 및 정지 코돈을 갖는 판독 프레임 또는 오직 개시 코돈만을 갖는 개방 판독 프레임(ORF)을 함유하지 않기 때문에, 바람직하게는 인공 단백질 또는 천연 단백질에 대한 암호화 영역의 부분(또는 이와 역)이 아닐 수 있다. 본 발명의 인공 NA 분자 중에 포함된 엑손은 인공 서열을 포함하기 때문에 인공 엑손이다. 본 명세서에서 "전사물"이란 단어는 달리 서술되지 않는 한, "성숙한 전사물"을 의미하는 것으로 해석될 것이다.
가장 광범위한 용어로, 전사물 "변이체"는 유전자의 전사물이며, 여기에서 상기 유전자의 적어도 2개의 전사물이 존재하고, 상기 전사물은 상기 적어도 2개의 전사물의 다른 하나와 적어도 하나의 뉴클레오티드("선택적인 전사 사건"에 의해 생성됨)만큼 상이하다. 그러나, 본 발명의 방법과 관련하여, 각 (전사물) 그룹의 인공 NA 분자는, 각 그룹에 대해 독립적으로, 적어도 80 뉴클레오티드 길이(바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 특히 적어도 200 nt)의 서열을 공유하며, 각 그룹에 대해 독립적으로, 각 그룹의 적어도 2개의 NA 분자는 적어도 80 뉴클레오티드 길이(바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 훨씬 더 바람직하게는 적어도 200 nt, 특히 적어도 300 nt)의 적어도 또 다른 서열만큼 상이하다. 상기 그룹의 다른 구성원들은 단지 하나의 뉴클레오티드만큼 추가의 구성원들과 상이할 수 있지만, 변이체들 간에 더욱 큰 차이, 예를 들어 상기 그룹의 모든 구성원들간에 단지 80 nt 또는 100 nt 또는 150 nt 또는 200 nt 신장부 이하의 서열 일치성이 바람직하다.
본 명세서에서, (인공 유전자의) "전사물 변이체를 모방하는"은 천연 진핵생물(바람직하게는 동물 또는 식물, 보다 바람직하게는 척추동물, 훨씬 더 바람직하게는 포유동물, 특히 인간) 유전자의 천연 진핵생물(바람직하게는 동물 또는 식물, 보다 바람직하게는 척추동물, 훨씬 더 바람직하게는 포유동물, 특히 인간) 전사물의 전형적인 특징을 가짐을 의미한다. 당해 분야의 숙련가는 전사물 변이체의 상기 전형적인 특징과 친숙하다. 이러한 특징은 하기 중 하나 이상을 포함한다: 하나 이상의 선택적인 스플라이싱 사건(하기 및 표 1 참조)의 결과이고, 몇몇 인트론 스플라이싱 부위 디뉴클레오티드(하기 및 표 2 참조)를 갖고, 선택적 전사물 개시- 및 종료-부위(하기 참조)를 갖고, 인티센스 전사물이고, 다른 유전자/전사물과 중복되고, 폴리아데닐화된다(또한 Wang et al., 2008 참조). 추가로, 또는 선택적으로, 왕(Wang) 등(2008), 특히 도 2에 정의된 특징들을 사용할 수 있다. 이롭게, 상기 참조 세트의 NA(RNA 또는 DNA) 분자 전체는 선행 2개의 문장에 인용된 특징들 중 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 훨씬 더 바람직하게는 적어도 4개, 특히 적어도 5개를 가지며, 이때 각각의 NA 분자는 서로 독립적으로, 적어도 하나 또는 적어도 2개 또는 적어도 3개 또는 적어도 4개의 별도의 경우에, 선행 문장에 인용된 특징들 중 어느 것도 갖지 않거나, 또는 1, 2, 3, 4, 5 또는 6개를 갖는다. 본 발명의 NA 분자는 전사물 변이체를 모방하기 위해서 RNA 분자일 필요는 없다. 전사물 변이체의 모방은 DNA 또는 다른 NA 분자에 의해서 또한 가능하다.
본 발명의 목적을 위해서, 인공 유전자를 포함하는 인공 게놈을 생성시킬 수 있다(개념상 컴퓨터에서, 서열들을 배열시킴으로써). 상기 인공 게놈의 서열을 또한 리드 할당에 사용할 수 있다. 인공 유전자는 천연 유전자로부터 공지된 특징, 예를 들어 프로모터, 전사 개시 부위, 전사된 영역 및 전사 종료 부위(또한 종결자라 지칭됨)를 갖는다. 상기 프로모터 영역은, 본 발명이 인공 유전자의 전사 변이체를 모방함에 관한 것이기 때문에(그리고 상기 인공 유전자 또는 상기 인공 유전자 자체로부터 상응하는 단백질의 합성이 아니기 때문에), 본 발명의 목적과 무관하다. 동일한 인공 유전자의 참조 전사물 변이체인 인공 NA 분자(즉 인공 NA 분자 그룹의 일원)는, 동일한 천연 유전자의 천연 전사물이 서로 및 상기 천연 유전자와 관련되는 바와 동일한 방식으로, 서로 및 상기 인공 유전자와 관련된다(크기 및 서열과 같은 매개변수에 의해). 이들의 공통적인 특징은 전사물 변이체가 동일한 가정 유전자로부터 전사되는 변이체들 간에 엑손(또는 그의 부분)을 공유하는 것일 수 있다. 본 발명의 목적을 위해서 상기 인공 유전자가 상기 인공 NA 분자를 한정하는 단순한 개념이며 상기 인공 NA 분자의 정의에 필요한 것 이상으로 한정될 필요는 없음은 숙련가에게 명백하다(예를 들어 이전에 언급한 바와 같이, 상기 유전자의 프로모터 영역을 한정할 필요는 없다).
이롭게, 전사물 변이체를 모방하는 인공 폴리핵산 NA(RNA 또는 DNA)의 참조 세트는 적어도 하나 또는 적어도 2개 또는 적어도 3개 또는 적어도 4개의 별도의 경우에, 상기 참조 세트 중에 존재하는 전형적인 전사물 특징 중 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 상기 전형적인 전사물 특징 중 적어도 3개, 특히 적어도 4개, 특히 전부에서, 진핵생물(바람직하게는 동물 또는 식물, 보다 바람직하게는 척추동물, 훨씬 더 바람직하게는 포유동물, 특히 인간) 전사체의 전형적인 전사물 특징(예를 들어 하기의 단락들에서 명시되는 바와 같은)의 상응하는 평균 빈도와 유사한(적어도 +/-50%, 바람직하게는 적어도 +/-25%, 특히 적어도 +/-10%) 선행 단락들에서 언급된 전형적인 전사물 특징의 빈도를 갖는다.
선택적 스플라이싱 사건(AS):
선택적 스플라이싱란 용어는 생물학에서 1차 전사물(전-mRNA)을 하나보다 많은 패턴으로 스플라이싱하여 다수의, 별개의 성숙한 mRNA를 생성시킬 수 있는 임의의 경우를 기술하는데 사용된다. 선택적 스플라이싱 사건의 가장 통상적인 유형들을 표 1에 나타낸다. 인간에서, 엑손 스키핑은 발견되는 가장 통상적인 스플라이싱 사건의 ∼33%를 차지한다. 선택적인 5' 및 3' 스플라이싱 부위가 각각 ∼25%로 이어진다. 또한, 선택적 스플라이싱 부위는 종종 함께 존재한다(Barbazuk et al., 2008; Roy et al., 2013). 뇌 조직 및 고환 조직은 다수의 AS 사건들을 갖는 것으로 밝혀졌다(Roy et al., 2013). 이롭게, 상기 참조 세트의 NA 분자 전체는 표 1에 인용된 특징들 중 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 훨씬 더 바람직하게는 적어도 4개, 특히 적어도 5개를 가지며, 이때 각각의 NA 분자는 서로 독립적으로 적어도 하나 또는 적어도 2개 또는 적어도 3개 또는 적어도 4개의 별도의 경우에, 선행 문장에서 인용된 특징들이 없거나, 상기 특징들 중 1, 2, 3, 4, 5, 6 또는 7개를 갖는다.
| AS 패턴 유형 | 약어 | 정의 |
|
카세트 엑손
( 스키핑된 엑손) |
CE | 하나의 엑손이 그의 인접하는 인트론과 함께 1차 전사물 밖으로 스플라이싱된다. |
| 인트론 유지 | IR | 하나의 서열이 인트론으로서 스플라이싱되거나 성숙한 mRNA 전사물 중에 남아있는다. |
| 상호 배타적인 엑손 | MXE | 다수의 카세트 엑손이 상호 배타적인 방식으로 사용되는 경우를 지칭한다. 가장 간단한 경우: 성숙한 mRNA 전사물 중에 결코 2개가 모두 포함되지 않는 2개의 연속적인 엑손. |
| 선택적인 3' 부위 | A3SS | 선택적인 수용체 부위를 또한 지칭한다. 2개 이상의 스플라이싱 부위가 엑손의 5' 단부에서 인식된다. 선택적인 3' 스플라이싱 접합(수용체 부위)이 사용되어, 하류 엑손의 5' 경계를 변화시킨다. |
| 선택적인 5' 부위 | A5SS | 선택적인 공여체 부위를 또한 지칭한다. 2개 이상의 스플라이싱 부위가 엑손의 3' 단부에서 인식된다. 선택적인 5' 스플라이싱 접합(공여체 부위)이 사용되어, 상류 엑손의 3' 경계를 변화시킨다. |
| 선택적인 첫 번째 엑손 | AFE | 각 변이체의 두 번째 엑손이 동일한 경계를 가지나, 제1 엑손은 상호 배타적이다. 이는 가능한 선택적 프로모터 사용을 어노테이션한다. |
| 선택적인 최종 엑손 | ALE | 각 스플라이싱 변이체의 끝에서 두 번째 엑손이 동일한 경계를 가지나, 최종 엑손은 상호 배타적이다. 이는 가능한 선택적인 폴리아데닐화 사용의 어노테이션을 허용한다. |
안티센스 전사물 및 중복 유전자:
중복 변이체뿐만 아니라 모노엑손 안티센스 전사물이 유전자 부분집합에 대해서 모든 전사물의 상당한 몫(인간에서 9%, 마우스에서 7.4%; Sanna et al., 2008)을 구성하는 것으로서 설계되었다. 상기 중복 변이체는 모노엑손이거나 센스 또는 안티센스 방향으로 스플라이싱될 수 있다(예를 들어 단지 말단 엑손 중복만을 갖는 3 엑손). 안티센스-배향된 유전자는 같은 방향의 중복 유전자보다 10배 더 빈번할 수 있다. 이롭게, 상기 참조 세트의 NA 분자 전체는 센스 및/또는 안티센스 방향으로 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 훨씬 더 바람직하게는 적어도 5개의 중복 전사물을 포함한다. 바람직하게, 상기와 같은 전사물의 빈도는 상기 참조 세트 중에 존재하는 모든 전사물의 약 10%이다. 2개의 인공 전사물 변이체간의 안티센스 중복은 예를 들어 10 nt 내지 500 nt의 길이일 수 있다.
선택적인 전사물 개시- 및 종료-부위(TSS 및 TES):
선택적인 첫 번째 및/또는 최종 엑손(AFE 및 ALE)을 생성시키는 선택적 스플라이싱 사건 외에, 또한 어노테이션된 엑손내 또는 엑손 전체에 상기 전사물의 실제 개시 또는 종료 부위가 가능하다. 미세-변화의 경우, 상기 어노테이션된 부위로부터의 정확한 편차는 논쟁의 여지가 있지만 대개는 <20 nt이다. 더욱이, 이들은 기능상 유사하다, 즉 동일한 프로모터 또는 동일한 폴리아데닐화 신호에 따르며, 따라서 이들은 조정시 함께 달라진다. 큰 변화의 경우, 이들 선택적인 TSS 및 TES는 전형적으로 선택적인 프로모터 또는 폴리아데닐화 신호에 따라 변하며 동일한 첫 번째 또는 최종 엑손내에 또는 이웃하는 것들 중에 위치할 수 있다. 이들은 더 떨어져 위치한다, 즉 프로모터들에 대한 참조 거리로서 500 nt가 고려될 수 있으며(Xin et al., 2008) 폴리-A 부위 측량시 조정 거리로서 40 nt가 관찰되었다(Yoon et al., 2012). 따라서, 이롭게, 상기 참조 세트의 NA 분자 전체는 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 훨씬 더 바람직하게는 적어도 5개의 TSS 및/또는 TES를 포함한다. 바람직하게, 하나의 그룹에서 적어도 2개의 전사물 변이체는 20 nt, 바람직하게는 10 nt의 긴 5' 또는 3' 말단 영역에서 적어도 1 nt, 바람직하게는 2 nt, 3 nt, 4 nt, 5 nt 이상 만큼 상이하다.
본 명세서에서, 선택적인 스플라이싱 사건, 선택적인 전사물 개시- 및 종료-부위 및 안티센스 전사물 및 중복 유전자를 "선택적인 전사 사건"이란 용어 하에 포함시킨다.
인트론 스플라이싱 부위 디뉴클레오티드:
대부분의 인트론은, 스플라이시오솜 성분에 의해 인식되고 스플라이시오솜 형성에 필요한 5' 및 3' 단부 부근의 공통의 공통 서열(consensus sequence)을 갖는다(도 1). 주요 부류의 경우, 스플라이싱 접합쌍은 고도로 보존되며 전형적으로 인트론 공여체 및 수용체 서열 GT-AG(어노테이션된 접합의 98.70%)를 포함하며, 이어서 GC-AG 및 AT-AC의 빈도로 이어진다(표 2). 보다 일반적인 관점에서, 가장 통상적인 엑손-인트론 서열을 엑손...AT(컷)GT...인트론...AG(컷)G... 다음 엑손으로서 묘사할 수 있다. 표 2에서, 공여체-수용체 쌍의 빈도를 제공한다. 이러한 보존 및 적당한 변이성을 밝히기 위해서, 모든 접합의 97%가 GT-AG이고, 2%는 GC-AG이며 1%는 AT-AC인 것을 목표로 하였다. 이러한 모방은 정렬자(aligner)(예를 들어 톱햇(TopHat))가 그의 기존의 접합 표를 사용하여 평가할 수 있게 해야 한다. 엑손 경계는 상기가 보다 중요한 인트론 접합 디뉴클레오티드를 방해하지 않는 5' AG 및 3' AT이어야 한다. 이롭게, 상기 참조 세트의 NA 분자 전체는 바람직하게는 각각 존재하는 모든 인트론 공여체-수용체 디뉴클레오티드의 약 97%, 2% 및 1%의 빈도로 GU-AG, GC-AG, AU-AC 중에서 선택된 바와 같은 엑손의 하나, 바람직하게는 2개, 특히 모든 인트론 공여체-수용체 디뉴클레오티드를 포함한다.
| # | 디뉴클레오티드 | 분율 | # | 디뉴클레오티드 | 분율 |
| 1 | GT -AG | 98.70% | 12 | AT-AG | 0.02% |
| 2 | GC -AG | 0.79% | 13 | GC-CT | 0.02% |
| 3 | AT - AC | 0.08% | 14 | GT-CT | 0.02% |
| 4 | GT-GG | 0.06% | 15 | GT-TT | 0.02% |
| 5 | GG-AG | 0.04% | 16 | AG-AG | 0.02% |
| 6 | GA-AG | 0.03% | 17 | GC-GG | 0.02% |
| 7 | GT-TG | 0.03% | 18 | GC-TG | 0.02% |
| 8 | AT-AT | 0.03% | 19 | GT-GA | 0.02% |
| 9 | GC-CA | 0.03% | 20 | CA-AG | 0.01% |
| 10 | GT-AT | 0.02% | 21 | CC-AT | 0.01% |
| 11 | AA-AG | 0.02% | 22 | GG-CA | 0.01% |
폴리아데닐화:
성숙한 진핵생물 전사물은 폴리-A 꼬리를 갖는 것으로 공지되어 있다. 이롭게, 본 발명의 또는 본 발명의 방법에 사용하기 위한 인공 NA 분자는 적어도 10, 바람직하게는 적어도 20, 특히 적어도 30 아데노신의 폴리-A 꼬리를 가지며, 이는 실제 전사물의 가까운 모방을 지원한다. 또한, 상기는 (특히 적어도 30 아데노신의 경우) 적합한 올리고(dT) 비드 정제를 보장하며, 또한 모든 구조물의 보편적인 증폭을 위한 T7-프로모터 및 폴리-A 결합 프라이머와의 PCR 증폭 반응에서 5'/3' 프라이머 융점(Tm)의 균형을 돕는다.
본 발명의 상기 방법은 바람직하게는 리드 생성(상기 리드는 임의의 길이를 가질 수 있다) 및 할당(즉 상기 리드를 참조 서열상에 지도화한다)을 근거로 NA 서열분석을 수행함을 포함하며, 여기에서 참조 리드 할당은 상기 참조 세트의 리드에 의해 생성되고 상기 참조 리드 할당을 사용하여 하나 이상의 샘플의 전사물 변이체의 리드 할당을 조절, 확인 또는 변형시킨다. 상기 리드 할당을 조절, 확인 또는 변형시키기 위해서 외부 대조군을 어떻게 사용하는지는 당해 분야에 공지되어 있다(예를 들어 Jiang et al., 2011).
본 발명의 과정에서, 용기 중에 건조 형태로(예를 들어 상기 샘플 자체에 의해 용해되는) 인공 NA 분자의 참조 세트를 제공함은 취급 오차를 감소시키는 것으로 밝혀졌다(또한 실시예 8을 참조하시오). 또한, NA 분자(특히 RNA 분자)는 전형적으로 건조시 보다 안정성이다. 따라서, 특히 바람직한 실시태양에서, 인공 NA 분자의 참조 세트를 용기 중에 건조하게, 바람직하게는 동결-건조시켜 제공한다. 전형적으로, 참조 세트를 갖는 별도의 용기를 각 샘플에 제공한다. 바람직하게, 안정화제(NA, 특히 RNA의 분해를 감소시키는)를 상기 참조 세트에, 상기 건조 전, 건조 도중 또는 건조 후에, 특히 건조 전에 가한다. 상기와 같은 안정화제는 산화방지제, EDTA, DDT, 다른 뉴클레아제 또는 RNAse 억제제(예를 들어 프로메가(Promega)의 RNAsin®, 바이오매트리카(Biomatrica)의 RNAstable®, 젠테그라(GenTegra)의 젠테그라®-RNA)를 포함한다. 전형적으로, DNA 분자보다 RNA 분자에 추가적인 안정화가 더 중요하다.
선행 단락에 따라, 또 다른 매우 바람직한 실시태양에서, 외부 대조군으로서 상기 참조 세트의 첨가를, 상기 샘플을 상기 용기에 가함으로써 수행하여 상기 샘플 중에 건조된 참조 세트를 용해시킨다.
하기는 상기 하나 이상의 샘플의 전사체 변이체의 리드 할당을 어떻게 조절, 확인 또는 변형시키는가에 대한 일례를 기재한다: 본 설정에서 유전자 1(G1)은 2개의 전사물 변이체, G1T1 및 G1T2를 가지며, 이들은 단지 하나의 보유된 인트론 서열에 의해 서로 상이하다. 정렬자가 상기 생성된 리드를, 개시 부위 분포, 서열 편향, 길이 편향 및 상기 언급된 스플라이싱 부위 디뉴클레오티드 어노테이션(표 2)과 같은 소정의 또는 유래된 정보의 상이한 가중치 모델을 사용하는 프로그램화된 확률 연산을 사용하여 상기 G1 유전자좌내에 분배하는 경우, 최종적으로 할당된 리드를 카운트하고 예를 들어 지도화된 백만 단편당 엑손의 킬로염기당 단편(FPKM)으로 표준화하여 상대적인 전사물 농도에 대한 하나의 척도 및 G1T1과 G1T2간의 비를 획득한다. 상기 실험 설정에 따라, 상기 FPKM 값은 매우 동일한 실험내의 기술적 복제물로부터 계산되거나 또는 선행 참조 실험으로부터 추정된 신뢰도 구간을 함유한다. 정렬 연산이 거짓 편향을 부과하고 거짓 발현 값을 생성시키는 경우 상기 G1T1 및 G1T2에 대한 결과는 틀린 채로 있으며, 더욱이 상기 샘플 자체 또는 실험 조건이 변하는 경우 완전히 제멋대로 될 수 있다. 유사한 복잡성(예를 들어 유사한 길이, 근접시 인트론 유지)을 갖는 참조 세트, Ref1T1 및 Ref1T2의 실측 자료 지식만이 리드 할당까지의 서열분석을 통한 상기 라이브러리 생성으로부터의 특정한 실험의 수행성능을 평가하고 유사한 복잡성의 유전자 및 전사물 변이체 분포의 신뢰도 구간을 계산할 수 있게 한다. 따라서 상기 참조 리드 할당을 사용하여, 예를 들어 바람직하게는 FPKM 값에 대한 표준화를 근거로 상기 샘플 리드의 통계학적 리드 할당을 조절 또는 이동시킬 수 있다. 상기 참조 세트의 리드 할당의 오차를 상기 참조 세트의 공지된 조성 및 양(주어진 플랫폼에 적합한, 느긋하게 선택될 수 있는 소정의 값)에 기인하여 보정할 수 있으며 상기 보정을 상기 샘플 리드 할당의 변형에 적용할 수 있다.
한편으로, 본 발명의 상기 방법은 바람직하게는 NA 검출 또는 정량분석 방법, 바람직하게는 마이크로-어레이 분석 또는 qPCR을 하나 이상의 샘플상에서 수행함을 포함하며, 여기에서 적어도 하나의 탐침은 상기 참조 세트의 적어도 하나의 NA 분자에 결합하고 상기 참조 세트의 적어도 하나의 NA 분자에 결합하는 적어도 하나의 탐침으로부터 생성되는 신호에 근거한 측정 결과를 사용하여 상기 NA 검출 또는 정량분석 방법에서 탐침에 결합하는 하나 이상의 샘플의 전사물 변이체로부터 생성되는 신호에 근거한 측정 결과를 조절, 확인 또는 변형시킨다. 외부 대조군을 사용하여 측정 결과를 조절, 확인 또는 변형시키는 방법은 당해 분야에 공지되어 있다. 예를 들어 문헌[Devonshire et al., 2010]을 참조하시오.
본 발명의 과정에서, 놀랍게도 상기 방법의 적용이 NA 서열분석 방법의 평가에 특히 적합한 것으로 밝혀졌다. 상기는 또한 NA 서열분석 방법의 평가, 또는 NA 검출 또는 정량분석 방법의 평가에 매우 적합하다. 따라서, 본 발명의 또 다른 태양에서, NA 서열분석 방법을 평가하거나 또는 NA 검출 또는 정량분석 방법을 평가하기 위한 방법을 제공하며, 상기 방법은
a) 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 특히 적어도 5개의 상이한 NA 분자 그룹을 포함하고, 이때 각각의 그룹이 적어도 2개, 바람직하게는 적어도 3개, 보다 바람직하게는 적어도 4개, 특히 적어도 5개의 상이한 NA 분자로 이루어지는, 전사물 변이체(앞서 설명된 바와 같은)를 모방하는 인공 NA 분자의 참조 세트를 제공하고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 모든 NA 분자는 동일한 인공 유전자의 참조 전사물 변이체이고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 NA 분자는 적어도 80 nt 길이, 바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 특히 적어도 200 nt의 서열을 공유하고, 상기 각 그룹의 적어도 2개의 NA 분자는 적어도 80 nt 길이, 바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 훨씬 더 바람직하게는 적어도 200 nt, 특히 적어도 300 nt의 적어도 또 다른 서열만큼 상이하며,
여기에서 상기 NA 분자의 적어도 2개, 바람직하게 각각은 소정의 몰량으로 존재하는 단계;
b1) 상기 NA 서열분석 방법을 평가하기 위해서, 리드 생성 및 할당에 기반한 NA 서열분석을 수행하고, 여기에서 참조 리드 할당이 상기 참조 세트의 리드에 의해 생성되는 단계; 또는
b2) 상기 NA 검출 또는 정량분석 방법을 평가하기 위해서, 상기 참조 세트상에서 상기 NA 검출 또는 정량분석 방법을 수행하고,
여기에서 적어도 하나의 탐침이 상기 참조 세트의 적어도 하나의 NA 분자에 결합하는 단계;
c) 임의의 단계 b)의 산출 결과, 특히 산출 몰량, 산출 농도, 및/또는 상기 NA 서열분석 방법 평가의 경우에, 상기 참조 세트의 NA 분자 중 적어도 하나의 할당된 리드의 수, 및/또는 상기 참조 세트의 적어도 2개의 NA 분자의 적어도 하나의 비를 상기 소정의 몰량에 비교하고/하거나, 상기 NA 서열분석 방법 평가의 경우에, 할당된 리드의 수 및/또는 상기로부터 계산되거나 예상되는 비 및/또는 산출결과에 비교하는 단계
를 포함한다.
본질적으로, 본 발명은 다양한 NA 분석 방법들을 "벤치마크"(또는 비교 또는 평가)하여, 조사자들(또는 NA 분석 방법 및/또는 NA 분석 장비의 생산자)로 하여금 그들의 방법을, 특히 전사물 변이체(복잡한 유기체의 전사체에 전형적이므로)를 신뢰성 있게 식별 및/또는 정량분석할 수 있음에 관하여 최적화되게 하는 방법을 제공한다.
상기 참조 세트에 대해 공지된 매개변수들(예를 들어 농도, 존재하는 서열 등 - 즉, 상기 참조 세트는 이 경우에 공지된 대조군을 나타낸다)로부터, 숙련가는 예상되는 결과(예를 들어 리드의 수, 외삽된 농도 등)를 계산하거나 예측할 수 있다. 상기 (실제) 산출 결과를 상기 예상 결과와 비교함으로서, 숙련가는 실제 결과와 예상 결과간의 상이함을 측정하여 상기 핵산 서열분석 방법을 평가할 수 있다.
현저하게, 또한 핵산 서열분석 방법의 계산적 태양을, 상이한 계산 방법 부분(예를 들어 연산)을 평가하거나 또는 상기 방법 부분(예를 들어 연산 또는 연산들)을 개선시키기 위해서 (반복적으로) 상기 참조 세트의 종래의 서열분석 측정을 사용하고 (반복적으로) 상기 서열분석 방법의 계산적 부분을 변화시킴으로써 평가할 수 있다.
이롭게, 본 발명의 임의의 참조 세트(하기 참조)는 특히 상기 참조 세트의 NA 분자의 적어도 2개, 바람직하게는 각각이 소정의 몰량으로 존재할 때, 상기 본 발명의 상기 방법에 적합하다.
본 발명의 과정에서, 다수의 상이한 참조 세트(및 그의 제조 방법)를 특성화하고 최종적으로 앞서 언급한 방법들에 특별히 매우 적합한 참조 세트(및 그의 제조 방법)를 발견하였다. (그러나, 상기 앞서 언급한 방법들은 본 발명의 참조 세트를 사용함으로 제한되지 않으며; 다른 참조 세트들도 또한 적합할 수 있다(그러나 본 발명의 참조 세트보다 덜 그렇다)).
따라서, 본 발명의 또 다른 태양에서, 전사물 변이체를 모방하는 인공 NA 분자, 바람직하게는 RNA 또는 DNA 분자의 참조 세트의 생성 방법을 제공하며, 상기 방법은 하기를 포함한다:
A) 천연 진핵생물 유전자, 바람직하게는 동물 또는 식물 유전자, 보다 바람직하게는 척추동물 유전자, 훨씬 더 바람직하게는 포유동물 유전자, 특히 인간 유전자의 그룹으로부터 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 특히 적어도 5개의 유전자를 선택한다. 이는 상기와 같은 유전자를 발견하는 분야에 공지되어 있다. 바람직하게, 상기 방법 단계를 소프트웨어로 컴퓨터-실행한다. 예를 들어, 상기(또는 다른 공개 데이터베이스에 사용하기 위한 그의 어노테이션된 서열 또는 그의 명칭)를 공개적으로 입수할 수 있는 데이터베이스, 예를 들어 Ensembl, 국립 생물공학 정보 센터(NCBI) GenBank 또는 다른 NCBI 데이터베이스로부터 획득할 수 있다. 예로서, 인간 유전자의 경우, 하기의 NCBI 검색 질의로부터 유전자를 선택할 수 있다: http://www.ncbi.nlm.nih.gov/gene/?term=Homo+sapiens[Orgn]
한편으로, 또는 추가로, Ensembl 데이터베이스(http://www.ensembl.org)에서 게놈을 훑어볼 수 있다.
바람직하게, 상기 유전자는 그의 전사물 변이체(전사물 표)에 관하여 충분히-어노테이션되어 있으며 인트론/엑손이 어노테이션되어 있다.
B) 각각의 선택된 유전자에 대해 적어도 2개, 바람직하게는 적어도 3개, 보다 바람직하게는 적어도 4개, 특히 적어도 5개의 천연 mRNA 전사물 변이체를 선택하고, 여기에서 각각의 전사물 변이체는 적어도 100 nt의 길이를 가지며 적어도 하나의 엑손을 포함한다. 바람직하게, 상기 방법 단계를 소프트웨어로 컴퓨터-실행한다. 예로서, 상기 Ensembl 데이터베이스는 유전자(예를 들어 인간 유전자)의 충분히-어노테이션된 전사물 변이체(또한 전사물 표라 칭한다)를 함유한다. 예를 들어 http://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000139618;r=13:32889611-32973805는 유전자 BRCA2의 전사물 표를 나타낸다. Ensembl은 또한 어노테이션된 스플라이싱 사건(ASE)을 함유한다(Wang et al., 2008; Koscielny et al., 2009). 상기 서열 어노테이션, 텍스트-기반 포맷으로서 FASTA 파일은 순수한 뉴클레오티드 서열을 나타내며, 전형적으로는 seqname - 염색체 또는 스캐폴드의 명칭과 같은 모든 관련된 정보를 함유하는 GTF 파일(일반적인 전송 포맷)에 통상적으로 유지되는 전사물 변이체 어노테이션과 함께 사용된다; 염색체 명칭을 'chr' 접두사와 함께 또는 상기 접두사 없이 제공할 수 있으며; 소스 - 상기 특징을 생성시킨 프로그램의 명칭, 또는 데이터 소스(데이터베이스 또는 프로젝트 명칭); 특징 - 특징 유형 명칭, 예를 들어 유전자, 변이, 유사성; 개시 - 1에서 시작하는 서열 넘버링을 갖는 상기 특징의 개시 위치; 종료 - 1에서 시작하는 서열 넘버링을 갖는 상기 특징의 종료 위치; 점수 - 이동 소수점 값; 가닥 - +(순방향) 또는 -(역방향)으로서 정의된다; 프레임 - '0', '1' 또는 '2' 중 하나. '0'은 상기 특징의 첫 번째 염기가 코돈의 첫 번째 염기임을 가리키고, '1'은 두 번째 염기가 코돈의 첫 번째 염기임을 가리키는 등이다; 속성 - 태그-값 쌍의 세미콜론-분리된 목록, 각각의 특징에 관한 추가적인 정보를 제공한다. 상기 GTF 파일로부터, 상이한 전사물들을 시각 검사를 위해 줌 기능을 갖는 프로그램에 의해 나타낼 수 있다.
C) 적어도 하나의 엑손을 포함하는 상기 선택된 천연 mRNA 전사물 변이체 각각의 서열을 제공하고, 임의로 여기에서 상기 서열은 또 다른 NA 유형, 예를 들어 DNA 서열로 전환된다. RNA를 DNA 서열로 전환시키는 것은 사소한 일이다. 바람직하게는 상기 방법 단계를 소프트웨어로 컴퓨터-실행한다. 이롭게, 상기 mRNA 전사물 변이체는 성숙한 전사물이다.
D) 단계 C)의 각 서열을 하기에 의해 변형시킨다:
각 서열의 각 엑손의 서열을 각각의 엑손에 대해 독립적으로, 대략 동일한 길이의 서열(엑손 서열로서)로 치환시키고,
여기에서 상기 대략 동일한 길이의 서열을 하기의 그룹 중에서 선택하며:
바이러스 서열, 박테리오파지 서열, 그의 역전된 서열, 임의의 다른 역전된 천연 서열(역전은 정렬 소프트웨어가 상기 서열의 그의 원래 유전자좌로의 정렬을 방지하고 또한 그의 원래 보체와의 하이브리드화를 방지한다), 비-천연 랜덤 서열, 및 이들의 조합, 바람직하게 상기 대략 동일한 길이의 서열을 하기의 그룹 중에서 선택하고:
바이러스 서열, 박테리오파지 서열, 그의 역전된 서열, 비-천연 랜덤 서열, 및 이들의 조합, 보다 바람직하게는 상기 대략 동일한 길이의 서열을 하기의 그룹 중에서 선택하고:
바이러스 서열, 박테리오파지 서열, 그의 역전된 서열, 및 이들의 조합,
바람직하게 여기에서 상기 대략 동일한 길이의 서열을 3개 이하, 바람직하게는 2개 이하, 특히 1개 이하의 디뉴클레오티드를 서로 독립적으로 임의의 다른 디뉴클레오티드에 의해, 바람직하게는 GT, GC 또는 AT에 의해 치환시키고/시키거나 3개 이하, 바람직하게는 2개 이하, 특히 1개 이하의 디뉴클레오티드를 서로 독립적으로 임의의 다른 디뉴클레오티드에 의해, 바람직하게는 AG, AC 또는 AT에 의해 치환시킴으로써 변형시키나, 단 바람직하게는 상기 디뉴클레오티드 교환을, 엑손-암호화된 인트론 접합 디뉴클레오티드의 풍부성이 예를 들어 엑손 좌표에 대한 정보(ICE) 데이터베이스(Chong et al., 2004)(하나의 서열에서 엑손인 것은 상기 다른 전사물 중에 존재하지 않음으로써 또 다른 전사물에 대한 인트론일 수 있다)에 제공된 바와 같은 천연 빈도를 반영하기 위해 90 내지 100%(GT-AG), 0 내지 10%(GC-AC) 및 0 내지 2%(AT-AT)이도록 수행해야 한다.
상기에 의해 인공 전사물 서열(적어도 하나의 인공 엑손을 포함한다)의 세트를 획득하나, 단
상기 동일한 선택된 유전자의 상기 선택된 천연 mRNA 전사물 변이체의 서열로부터 획득된 인공 전사물 서열은 적어도 80 nt 길이의 서열(바람직하게는 단일 엑손 서열 중에 포함된다)을 공유해야 하며, 바람직하게는 단,
단계 C)의 서열의 엑손 서열이 단계 C)의 서열의 또 다른 엑손 서열에 일치하는 경우, 상기 엑손 서열 및 상기 또 다른 엑손 서열은 대략 동일한 길이의 동일한 상기 서열에 의해 치환되어야 한다.
바람직하게, 상기 방법 단계를 소프트웨어에 의해 컴퓨터-실행한다. 상기 단계(및 모든 후속의 바람직한 컴퓨터 단계)를 예를 들어 널리 사용되는 소프트웨어 CLC 메인 워크벤치(Main Workbench)(퀴아겐(QIAGEN)), 바이오컨덕터(Bioconductor) 패키지, UCSC 게놈 브라우저, 또는 다른 것들로 수행할 수 있다.
서열들을 또한, 특히 바이러스 서열, 박테리오파지 서열, 그의 역전된 서열, 임의의 다른 역전된 천연 서열, 또는 비-천연 랜덤 서열이 전체 엑손을 채우기에 너무 짧은 경우, 대략 동일한 길이의 서열을 형성하도록 합할 수도 있다.
이롭게, 바이러스 서열, 박테리오파지 서열, 그의 역전된 서열, 또는 임의의 다른 역전된 천연 서열 또는 비-천연 랜덤 서열의 길이는, 특히 너무 많은 짧은 서열 신장부들이 결합하여 불리하게 진핵생물 서열에 너무 상동성인 서열을 생성시키는 것을 피하기 위해서, 적어도 10 nt, 바람직하게는 적어도 20 nt, 보다 바람직하게는 적어도 50 nt, 특히 적어도 100 nt이다.
이롭게, 몇몇 제한 부위들을 단일의 점 돌연변이를 도입시킴으로써(예를 들어 XhoI 및 NsiI의 제한 부위를 제거함으로써) 상기 인공 전사물 서열로부터 제거하여 클로닝시 보다 양호한 처리를 허용한다.
E) 단계 D)의 세트의 인공 전사물 서열 중 적어도 하나를 임의로 중복시키고 상기 중복된 서열을 상기 세트에 가하여, 단계 F) 내지 K) 중 하나 이상에서 선택적 변형을 위한 사본을 포함하는 세트를 획득한다.
상기 중복은 상기 참조 세트 중에 존재해야 하는 전사물 변화 사건의 모방을 허용하지만(상기 참조 세트가 보다 적합할 수록 선택적 전사 사건이 보다 광범위하게 획득된다), 상기 선택된 유전자와 함께 발생하지는 않는다. 바람직하게, 상기 방법 단계를 소프트웨어로 컴퓨터-실행한다.
F) 적어도 하나의 서열을 상기 세트의 인공 전사물 서열의 적어도 하나에 임의로 삽입하고,
여기에서 상기 적어도 하나의 삽입된 서열은 각각 서로 독립적으로 단계 D)의 인공 전사물 서열 중 어느 하나의 동일한 길이의 센스 또는 안티-센스 서열(즉 역 보체 서열)에 일치하며 바람직하게는 5 nt 내지 10000 nt, 특히 10 nt 내지 1000 nt의 길이를 갖는다.
이롭게, 인공 전사물 서열당 5개 이하, 바람직하게는 4개 이하, 보다 바람직하게는 3개 이하, 특히 2개 이하의 삽입이 수행된다. 바람직하게, 상기 방법 단계를 소프트웨어로 컴퓨터-실행한다.
G) 상기 세트의 인공 전사물 서열 중 적어도 하나로부터 1 nt 내지 10000 nt 범위의 길이를 갖는 적어도 하나의 서열을 임의로 제거하고,
여기에서 상기 하나 이상의 인공 전사물 서열은 각각 적어도 100 nt의 크기로 남아있으며 적어도 하나의 엑손 서열을 포함하는 상태로 남아있는다.
이롭게, 인공 전사물 서열당 5개 이하, 바람직하게는 4개 이하, 보다 바람직하게는 3개 이하, 특히 2개 이하의 제거를 수행한다. 바람직하게, 상기 방법 단계를 소프트웨어로 컴퓨터-실행한다.
단계 E 내지 G의 조합에 의해, 상기 선택된 천연 mRNA 전사물 중에 존재하지 않는 추가적인 선택적 전사 사건을 포함시키는 것이 가능하다. 바람직하게, 상기 방법 단계를 소프트웨어로 컴퓨터-실행한다.
H) 상기 인공 전사물 서열 각각의 첫 번째 뉴클레오티드로서 구아노신을, 5' 단부가 구아노신일 때까지 상기 서열을 5' 절두시킴으로써, 첫 번째 염기를 구아노신으로 교환함으로써 또는 구아노신을 5' 단부에 가함으로써, 바람직하게는 5' 단부가 구아노신일 때까지 상기 서열을 5' 절두시킴으로써, 또는 첫 번째 염기를 구아노신으로 교환함으로써, 특히 5' 단부가 구아노신일 때까지 상기 서열을 5' 절두시킴으로써 임의로 확립시킨다.
상기 첫 번째 염기가 구아노신인 것은 T7 폴리머라제에 의한 효율적인 전사를 허용한다. 바람직하게, 상기 방법 단계를 소프트웨어로 컴퓨터-실행한다.
I) 상기 인공 전사물 서열의 세트가 GAA, GAC, GAG, GAT, GCA, GCC, GCG, GCT, GGA, GGC, GGG, GGT, GTA, GTC, GTG, GTT 중에서 선택된 5' 개시 트리뉴클레오티드 또는 AA, AC, AG, AT, CA, CC, CG, CT, GA, GC, GG, GT, TA, TC, TG, TT 중에서 선택된 5' 개시 디뉴클레오티드 및/또는 AC, AG, AT, CC, CG, CT, GC, GG, GT, TC, TG, TT 중에서 선택된 3' 종료 디뉴클레오티드의 필수적으로 랜덤하게 분포된 존재를 갖도록 상기 세트의 인공 전사물 서열 중 적어도 하나를 임의로 변형시킨다. 바람직하게, 상기 방법 단계를 소프트웨어로 컴퓨터-실행한다. 이는 상기 생성된 참조 세트를 WO 2011/095501 A1에 개시된 복잡성 감소 방법에 양립성이고 특히 적합하게 한다.
본 명세서에서, 전체 발명과 관련해서뿐만 아니라, "필수적으로 랜덤하게 분포된 존재"(본 발명의 목적을 위해서)(상기는 "필수적으로 균일하게 분포된 존재"일 수도 있다)를 가짐은 - 광범위하게 사용되는 카이-제곱 검정(피어슨(Pearson)에 의해 개발된 바와 같은)을 적합한 분포로서 별개의 균일한 분포(즉 모든 사건이 균등하게 있음직함)를 갖는 상기 존재에 적용할 때 - 상기 생성되는 p 값(전형적으로 상기 카이-제곱 값에 대해 표로 작성된다)이 0.1 초과, 바람직하게는 0.2 초과, 보다 바람직하게는 0.3 초과, 훨씬 더 바람직하게는 0.5 초과, 특히 0.8 초과임을 의미한다. 상기 카이-제곱 검정을 적용하는 방법은 당해 분야에 주지되어 있다. 상기 카이-제곱 검정을 적용하는 방법에 대해서 또한 실시예 4를 참조하시오.
J) 바람직하게는 폴리-A 꼬리 서열을, 바람직하게는 적어도 10개, 특히 적어도 20개 아데노신으로 이루어지는 상기 세트의 인공 전사물 서열 중 하나 이상, 바람직하게는 전부에 가한다. 바람직하게, 상기 방법 단계를 소프트웨어로 컴퓨터-실행한다. 임의로, 상기 폴리-A 꼬리 뒤에 지표 서열(DNA 바코드 또는 서열 표지)을 상기 세트의 인공 전사물 서열 중 하나 이상, 바람직하게는 전부에 가한다. 상기 지표 서열은 상기 참조 세트의 제조 중 선택적인 정량분석 및 확인 방법을 가능하게 하지만, 참조 서열로서 적용 중에는 가릴 필요가 있다. 상기 가림은, 상기 지표 서열을, 특정한 이어지는 작업흐름(폴리-A 프라이밍을 포함한 RNA 서열분석 프로토콜)에 의해 보이지 않거나 또는 상기 지표 서열을 임의의 잠재적인 리드 및 참조 어노테이션에서 감추어야 하는 상기 폴리-꼬리 밖에 놓음으로써 성취될 수 있다. 바람직하게, 상기 방법 단계를 소프트웨어로 컴퓨터-실행하거나,
K) 또는 바람직하게는 단계 E 내지 J 중 적어도 2개의 임의의 조합으로 수행하며, 바람직하게는 여기에서 각각의 방법 단계를 단지 1회만 수행하고;
L) 상기 세트의 각각의 인공 전사물 서열의 경우:
상기 전체 인공 전사물 서열을 포함하는 NA 분자를 물리적으로 합성한다. NA, 특히 DNA 및 RNA 분자를 합성하는 방법은 당해 분야에 공지되어 있다. DNA 및 RNA를 생체내(재조합 세포, 예를 들어 이 콜라이에서 발현된다) 또는 시험관내 생화학적 방법(예를 들어 DNA/RNA 폴리머라제에 의한 합성/증폭, 예를 들어 폴리머라제 쇄 반응 - PCR)에 의해 생성시킬 수 있을 뿐만 아니라 화학적으로 합성시킬 수 있다. 상기 인공 NA가 DNA인 경우, 상기를 바람직하게는 드노보 DNA 합성에 의해 합성하고 PCR에 의해 증폭시킨다. 플라스미드내로의 클로닝에 의한 생체내 증폭, 미생물내로의 형질전환, 서열-확인 및 상기 형질전환된 미생물의 성장이 또한 가능하다. 상기 DNA 주형으로부터, RNA를 T7 RNA 폴리머라제에 의한 전사에 의해 합성할 수 있다. 바람직하게, 상기 NA가 RNA인 경우, 상기를 특히 T7 RNA 폴리머라제에 의해 DNA로부터 전사시킨다.
M) 바람직하게, 단계 L)의 NA 분자가 RNA 분자인 경우, 5' 캡-구조를 상기 RNA 분자에 물리적으로 가한다. 이는 실제 진핵생물 전사물의 훨씬 더 가까운 모방을 성취한다. mRNA의 캡핑을 효소적으로, 예를 들어 우두 캡핑 시스템(뉴잉글랜드 바이오랩스 인코포레이티드(New England BioLabs, Inc.)에 의해 수행할 수 있다. 또한 WO 2009/058911 A2를 참조하시오;
상기에 의해, 바람직하게는 RNA 또는 DNA 분자의 참조 세트인 전사물 변이체를 모방하는 인공 NA 분자의 참조 세트를 물리적으로 획득한다.
바람직한 실시태양에서, 단계 D) 내지 G), 바람직하게는 모든 단계를, 상기 인공 NA 분자의 참조 세트가 진핵생물 유전자, 바람직하게는 동물 또는 식물 유전자, 보다 바람직하게는 척추동물 유전자, 훨씬 더 바람직하게는 포유동물 유전자, 특히 인간 유전자에 대해 자연에서 발생하는 선택적 전사 사건을 모방하는 한 수행하며, 상기 사건은 바람직하게는 하기의 그룹 중에서 선택된다:
선택적인 전사물 개시 부위(TSS), 선택적인 전사물 종료 부위(TES), 안티센스 전사물, 중복 전사물, 및 스키핑된(skipped) 카세트 엑손(CE), 인트론 유지(IR), 상호 배타적인 엑손(MXE), 선택적인 3' 스플라이싱 부위(A3SS), 선택적인 5' 스플라이싱 부위(A5SS), 선택적인 첫 번째 엑손(AFE), 선택적인 최종 엑손(ALE) 및 트랜스-스플라이싱의 그룹 중에서 선택된 선택적인 스플라이싱 사건들.
또 다른 바람직한 실시태양에서, 인공 NA 분자의 참조 세트는 하기의 그룹 중에서 선택된 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 훨씬 더 바람직하게는 적어도 5개, 특히 모든 선택적인 전사 사건들을 모방한다:
선택적인 전사물 개시 부위(TSS), 선택적인 전사물 종료 부위(TES), 안티센스 전사물, 중복 전사물, 및 스키핑된 카세트 엑손(CE), 인트론 유지(IR), 상호 배타적인 엑손(MXE), 선택적인 3' 스플라이싱 부위(A3SS), 선택적인 5' 스플라이싱 부위(A5SS), 선택적인 첫 번째 엑손(AFE), 선택적인 최종 엑손(ALE) 및 트랜스-스플라이싱의 그룹 중에서 선택된 선택적인 스플라이싱 사건들.
또 다른 바람직한 실시태양에서, 상기 인공 NA 분자의 참조 세트의 모든 엑손 서열내 모든 인트론 개시 디뉴클레오티드의 적어도 50%, 바람직하게는 적어도 75%, 특히 적어도 95%는 GT이며, 여기에서 상기 인트론 개시 디뉴클레오티드는 각각 상기 참조 세트의 또 다른 인공 NA 분자 중에 존재하지 않는 서열의 5' 말단 디뉴클레오티드이고 이에 의해 상기는 상기 또 다른 인공 NA 분자에 대한 인트론을 나타내고/내거나(바람직하게는 나타내고), 상기 인공 NA 분자의 참조 세트의 모든 엑손 서열내 모든 인트론 종료 디뉴클레오티드의 적어도 50%, 바람직하게는 적어도 75%, 특히 적어도 95%는 AT이며, 여기에서 상기 인트론 종료 디뉴클레오티드는 각각 상기 참조 세트의 또 다른 인공 NA 분자 중에 존재하지 않는 서열의 5' 말단 디뉴클레오티드이고 이에 의해 상기는 상기 또 다른 인공 NA 분자에 대한 인트론을 나타낸다.
또 다른 바람직한 실시태양에서, 상기 인공 NA 분자의 참조 세트는 500 nt 내지 2000 nt, 바람직하게는 750 nt 내지 1500 nt, 특히 1000 nt 내지 1400 nt의 평균 서열 길이를 가지며; 바람직하게는 300 nt 내지 1200 nt, 바람직하게는 600 nt 내지 900 nt, 특히 700 nt 내지 800 nt의 표준 편차; 적어도 100 nt의 최소 크기; 및 바람직하게는 10000 nt의 최대 크기를 갖는다.
또 다른 바람직한 실시태양에서, 상기 인공 NA 분자의 참조 세트는 GAA, GAC, GAG, GAT, GCA, GCC, GCG, GCT, GGA, GGC, GGG, GGT, GTA, GTC, GTG, GTT 중에서 선택된 5' 개시 트리뉴클레오티드 또는 AA, AC, AG, AT, CA, CC, CG, CT, GA, GC, GG, GT, TA, TC, TG, TT 중에서 선택된 5' 개시 디뉴클레오티드 및/또는 AC, AG, AT, CC, CG, CT, GC, GG, GT, TC, TG, TT 중에서 선택된 3' 종료 디뉴클레오티드의 필수적으로 랜덤하게 분포된 존재를 갖는다. 이는 상기 생성된 참조 세트를 WO 2011/095501 A1에 개시된 복잡성 감소 방법에 특히 적합하게 한다.
또 다른 바람직한 실시태양에서, 상기 참조 세트의 적어도 50%, 바람직하게는 전체 인공 NA 분자는 25% 내지 55%의 평균 GC 함량을 갖는다. 바람직하게, 상기 평균 GC 함량은 천연 유전자가 선택되는 종들(또는 계통발생 그룹)의 전사물의 평균 GC 함량과 동일하도록 선택된다.
또 다른 바람직한 실시태양에서, 상기 참조 세트의 각각의 인공 NA 분자는 5' 개시 뉴클레오티드로서 구아노신을 갖는다.
또 다른 바람직한 실시태양에서, 상기 참조 세트의 인공 NA 분자 중 적어도 하나, 바람직하게는 각각은 상기가 RNA 분자인 경우 5'-캡 구조를 갖는다.
또 다른 바람직한 실시태양에서, 상기 방법은 상기 인공 NA 분자의 참조 세트를 제공함을 또한 포함하며, 여기에서 상기 참조 세트의 NA 분자 중 적어도 2개, 바람직하게 각각은, 바람직하게는 동일한 용기 중에 소정의 몰량으로 존재한다. 이롭게, 상기는 사용 준비가 된 키트의 형태로 제공된다. 바람직하게, 상기 NA 분자의 적어도 2개의 각각의 몰량은 적어도 102, 바람직하게는 적어도 103, 보다 바람직하게는 적어도 105, 특히 적어도 106배만큼 상이하며, 특히 상기 NA 분자 중 적어도 2개는 액체 중에 용해된 상태로 제공되거나 또는 액체 중에 용해되거나 희석될 준비가 되어 있으며, 여기에서 그들 각각의 농도 또는 최종 농도 범위는 0.01 아토몰/㎕ 내지 100 펨토몰/㎕, 또는 100 젭토몰/㎕ 내지 1 펨토몰/㎕이다.
상기에 논의된 바와 같이, 안정화 및 처리 오차의 감소가 중요하다. 따라서, 매우 바람직한 실시태양에서, 본 발명의 방법은 바람직하게는 안정화제와 함께, 바람직하게는 용기 중에서 물리적으로 획득된 참조 세트를 건조, 바람직하게는 동결-건조시키는 단계를 포함한다.
또 다른 바람직한 실시태양에서, 인공 NA 분자의 참조 세트의 서열은 NCBI GenBank 데이터베이스 수납 번호가 표 3에 나열된(즉 대부분의 공지된 진핵생물 서열과 유사성을 갖지 않는다), 바람직하게는 표 3 및 표 4 중 어느 하나에 나열된(즉 대부분의 공지된 진핵생물 및 대부분의 공지된 원핵생물/바이러스 서열 모두와 유사성을 갖지 않는다) 서열, 특히 2014년 6월 15일자 발매 NCBI GenBank 데이터베이스 202의 모든 서열과 유사성을 갖지 않으며, 이때 통계학적 유의수준 한계(예상 한계)는 10-1 미만, 바람직하게는 1 미만, 특히 10 미만이다. 상기 유사성을 하기의 매개변수들을 갖는 BLASTn 프로그램에 의해 측정한다: 낮은 복잡성 영역의 필터링, 1차 갭 비용(linear gap cost) 및 1, -2의 매치/미스매치 점수와 함께 28의 워드 크기. 상기 통계학적 유의수준 한계의 설명에 대해서 문헌[Karlin & Altschul, 1990], 및 GenBank에의 도입에 대해서 문헌[Benson et al., 2013]을 참조하시오. 상기 실시태양은 복잡한 샘플에 첨가시에조차 상기 참조 세트의 서열의 명확한 식별을 허용하기 때문에(상기가 예를 들어 RNA-seq에 의해 쉽게 성취될 수 있는, 예를 들어 30 nt의 최소 길이를 갖는 한) 본 발명의 문제를 해결하기에 뜻밖에도 대단히-적합하다. 현행 GenBank 버전을 ftp://ftp.ncbi.nlm.nih.gov/genbank/ 하에서 다운로드용으로 자유롭게 입수할 수 있으며, BLAST 소프트웨어는 ftp://ftp.ncbi.nlm.nih.gov/blast/executables/blast+/ 하에서 다운로드용으로 자유롭게 입수할 수 있다. 사용이 용이한 GenBank의 BLAST 검색이 또한 http://blast.ncbi.nlm.nih.gov/Blast.cgi (뉴클레오티드 블라스트, 선택된 데이터베이스 뉴클레오티드 수집(nr/nt), 매우 유사한 서열(메가블라스트))상에서 가능하다.
본 발명은 또한 본 발명의 상기 방법의 임의의 실시태양에 의해(특히 본 명세서에서 명백히 언급된 실시태양에 의해) 획득될 수 있는, 전사물 변이체를 모방하는 인공 NA 분자의 참조 세트를 제공한다.
본 발명의 또 다른 태양에서, NA 분자 중 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 특히 적어도 5개 그룹을 포함하는 전사물 변이체, 바람직하게는 RNA 분자 또는 DNA 분자, 특히 RNA 분자를 모방하는 인공 NA 분자의 참조 세트를 제공하며, 이때 각 그룹은 적어도 2개, 바람직하게는 적어도 3개, 보다 바람직하게는 적어도 4개, 특히 적어도 5개의 상이한 NA 분자로 이루어지고,
여기에서 각 그룹에 대해 독립적으로, 상기 각 그룹의 모든 NA 분자는 동일한 인공 유전자의 참조 전사물 변이체이고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 NA 분자는 적어도 80 nt 길이, 바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 특히 적어도 200 nt의 서열을 공유하고, 상기 각 그룹의 적어도 2개의 NA 분자는 적어도 80 nt 길이, 바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 훨씬 더 바람직하게는 적어도 200 nt, 특히 적어도 300 nt의 적어도 또 다른 서열만큼 상이하다.
본 발명의 과정에서, 인공 NA 분자의 참조 세트는 본 발명의 목적에 특별히 적합한 것으로 밝혀졌다. 상기 분자를 SIRV(스파이크-인 RNA 변이체)라 칭하며 본 발명의 경우 서열번호 1 내지 148(실시예 1 참조)에 개시되어 있다. 따라서, 또 다른 태양에서, 본 발명은 서열번호 1 내지 148의 그룹 중에서 선택된 전체 서열과 적어도 50%, 바람직하게는 적어도 60%, 보다 바람직하게는 적어도 70%, 훨씬 더 바람직하게는 적어도 80%, 더욱 훨씬 더 바람직하게는 적어도 90% 또는 적어도 95%, 특히 100% 일치하는 서열을 포함하는 NA 분자, 바람직하게는 DNA 분자 또는 RNA 분자를 제공한다. 상기 서열의 큰 변화는 상기 서열이 오직 NA 분석 방법에서 참조 서열로서 사용하기 위한 것인 한 생물학적 기능이 보존될 필요가 없기 때문에 가능하다. 바람직하게 상기 서열번호에 대한 변화는 상기에서 말한 바와 같이 표 3의 서열에 유사성을 갖지 않는다. 이러한 변화는 상술한 방법에 의해 획득될 수 있다.
상기 SIRV의 엑손은 자체가 또 다른 서열에 포함되는 경우에 조차 본 발명의 목적에 매우 적합하기 때문에, 본 발명은 또한 서열번호 156 내지 334의 그룹 중에서 선택된 전체 서열과 적어도 50%, 바람직하게는 적어도 60%, 보다 바람직하게는 적어도 70%, 훨씬 더 바람직하게는 적어도 80%, 더욱 훨씬 더 바람직하게는 적어도 90% 또는 적어도 95%, 특히 100% 일치하는 서열을 갖는 적어도 하나의 엑손을 갖는 서열을 포함하는 NA 분자, 바람직하게는 DNA 분자 또는 RNA 분자를 제공한다.
또한, 상기 SIRV의 단편은 또 다른 NA 분자에 포함될 때 본 발명의 목적에 유용하다. 따라서 본 발명은 또한 적어도 80개, 바람직하게는 적어도 150개, 바람직하게는 적어도 200개, 보다 바람직하게는 적어도 300개, 특히 적어도 400개의 연속적인 뉴클레오티드의 서열을 포함하는 NA 분자, 바람직하게는 DNA 분자 또는 RNA 분자를 제공하며, 상기 서열은 서열 단편과 적어도 50%, 바람직하게는 적어도 60%, 보다 바람직하게는 적어도 70%, 훨씬 더 바람직하게는 적어도 80%, 더욱 훨씬 더 바람직하게는 적어도 90% 또는 적어도 95%, 특히 100% 일치하고, 서열번호 1 내지 148의 그룹 중에서 선택된 서열의 적어도 80 nt, 바람직하게는 적어도 150 nt, 바람직하게는 적어도 200 nt, 보다 바람직하게는 적어도 300 nt, 특히 적어도 400 nt의 최소 크기를 갖는다.
바람직한 실시태양에서, 본 발명의 NA 분자는 NA 분자 중 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 특히 적어도 5개 그룹을 포함하는, 전사물 변이체를 모방하는 인공적인 NA 분자의 참조 세트로서 제공되며, 이때 각 그룹은 적어도 2개, 바람직하게는 적어도 3개, 보다 바람직하게는 적어도 4개, 특히 적어도 5개의 상이한 본 발명의 NA 분자로 이루어지고, 여기에서 각 그룹에 대해 독립적으로, 상기 각 그룹의 모든 NA 분자는 동일한 인공 유전자의 참조 전사물 변이체이며, 여기에서 각 그룹에 대해 독립적으로, 상기 각 그룹의 NA 분자는 적어도 80 nt 길이, 바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 특히 적어도 200 nt의 서열을 공유하고, 상기 각 그룹의 적어도 2개의 NA 분자는 적어도 80 nt 길이, 바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 훨씬 더 바람직하게는 적어도 200 nt, 특히 적어도 300 nt의 적어도 또 다른 서열만큼 상이하다.
바람직하게, 본 발명의 임의의 참조 세트는 하기의 그룹 중에서 선택된 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 훨씬 더 바람직하게는 적어도 5개, 특히 모든 선택적인 전사 사건을 모방한다:
선택적인 전사물 개시 부위(TSS), 선택적인 전사물 종료 부위(TES), 안티센스 전사물, 중복 전사물, 및 스키핑된 카세트 엑손(CE), 인트론 유지(IR), 상호 배타적인 엑손(MXE), 선택적인 3' 스플라이싱 부위(A3SS), 선택적인 5' 스플라이싱 부위(A5SS), 선택적인 첫 번째 엑손(AFE), 선택적인 최종 엑손(ALE) 및 트랜스-스플라이싱의 그룹 중에서 선택된 선택적인 스플라이싱 사건들.
본 발명의 임의의 참조 세트의 또 다른 바람직한 실시태양에서, 인공 NA 분자의 참조 세트의 모든 엑손 서열내 모든 인트론 개시 디뉴클레오티드의 적어도 50%, 바람직하게는 적어도 75%, 특히 적어도 95%는 GT이며, 여기에서 상기 인트론 개시 디뉴클레오티드는 각각 상기 참조 세트의 또 다른 인공 NA 분자 중에 존재하지 않는 서열의 5' 말단 디뉴클레오티드이고 이에 의해 상기는 상기 또 다른 인공 NA 분자에 대한 인트론을 나타내고/내거나(바람직하게는 나타내고), 상기 인공 NA 분자의 참조 세트의 모든 엑손 서열내 모든 인트론 종료 디뉴클레오티드의 적어도 50%, 바람직하게는 적어도 75%, 특히 적어도 95%는 AT이며, 여기에서 상기 인트론 종료 디뉴클레오티드는 각각 상기 참조 세트의 또 다른 인공 NA 분자 중에 존재하지 않는 서열의 5' 말단 디뉴클레오티드이고 이에 의해 상기는 상기 또 다른 인공 NA 분자에 대한 인트론을 나타낸다.
또 다른 바람직한 실시태양에서, 본 발명의 임의의 참조 세트는 500 nt 내지 2000 nt, 바람직하게는 750 nt 내지 1500 nt, 특히 1000 nt 내지 1400 nt의 평균 서열 길이를 가지며; 바람직하게는 300 nt 내지 1200 nt, 바람직하게는 600 nt 내지 900 nt, 특히 700 nt 내지 800 nt의 표준 편차; 적어도 100 nt의 최소 크기; 및 바람직하게는 10000 nt의 최대 크기를 갖는다.
또 다른 바람직한 실시태양에서, 본 발명의 임의의 참조 세트는 25% 내지 55%의 평균 GC 함량을 갖는다.
또 다른 바람직한 실시태양에서, 본 발명의 임의의 참조 세트는 GAA, GAC, GAG, GAT, GCA, GCC, GCG, GCT, GGA, GGC, GGG, GGT, GTA, GTC, GTG, GTT 중에서 선택된 5' 개시 트리뉴클레오티드 또는 AA, AC, AG, AT, CA, CC, CG, CT, GA, GC, GG, GT, TA, TC, TG, TT 중에서 선택된 5' 개시 디뉴클레오티드 및/또는 AC, AG, AT, CC, CG, CT, GC, GG, GT, TC, TG, TT 중에서 선택된 3' 종료 디뉴클레오티드의 필수적으로 랜덤하게 분포된 존재를 갖는다.
또 다른 바람직한 실시태양에서, 본 발명의 임의의 참조 세트의 각각의 인공 NA 분자는 5' 개시 뉴클레오티드로서 구아노신을 갖는다.
또 다른 바람직한 실시태양에서, 본 발명의 임의의 참조 세트의 인공 NA 분자 중 적어도 하나, 바람직하게는 각각은, 상기가 RNA 분자인 경우, 5'-캡 구조를 갖고/갖거나 적어도 10, 바람직하게는 적어도 20, 특히 적어도 30개 아데노신의 폴리-A 꼬리를 갖는다. 바람직하게, 본 발명의 임의의 참조 세트의 서열은 NCBI GenBank 데이터베이스 수납 번호가 표 3에 나열된, 바람직하게는 표 3 및 표 4 중 어느 하나에 나열된 서열, 특히 2014년 6월 15일자 발매 NCBI GenBank 데이터베이스 202의 모든 서열과 유사성을 갖지 않으며, 이때 통계학적 유의수준 한계(예상 한계)는 10-1 미만, 바람직하게는 1 미만, 특히 10 미만이고, 여기에서 상기 유사성을 하기의 매개변수들을 갖는 BLASTn 프로그램에 의해 측정한다: 낮은 복잡성 영역의 필터링, 1차 갭 비용 및 1, -2의 매치/미스매치 점수와 함께 28의 워드 크기.
특히 바람직한 실시태양에서, 본 발명의 인공 NA 분자의 임의의 참조 세트를 제공하며, 여기에서 상기 NA 분자 중 적어도 2개, 바람직하게 각각은, 바람직하게는 동일한 용기 중에 소정의 몰량으로 존재하고; 바람직하게, 상기 NA 분자의 적어도 2개의 각각의 몰량은 적어도 102, 바람직하게는 적어도 103, 보다 바람직하게는 적어도 105, 특히 적어도 106배만큼 상이하며, 특히 상기 NA 분자 중 적어도 2개는 액체 중에 용해된 상태로 제공되거나 또는 액체 중에 용해되거나 희석될 준비가 되어 있으며, 여기에서 그들 각각의 농도 또는 최종 농도 범위는 0.01 아토몰/㎕ 내지 100 펨토몰/㎕, 또는 100 젭토몰/㎕ 내지 1 펨토몰/㎕이다. 광범위한 농도를 갖는 것은, 예를 들어 높은 동적 범위의 검출을 갖는 장비 및 방법을 개발하는 것이 보다 큰 도전이기 때문에, 장비 및 방법(예를 들어 RNA-seq에서) 평가에 보다 양호하다.
상기에 논의된 바와 같이, 처리 오차의 안정화 및 감소는 중요하다. 상응하게, 또 다른, 특히 바람직한 실시태양에서, 본 발명의 인공 NA 분자의 참조 세트를 용기 중에서, 바람직하게는 안정화제와 함께 건조, 바람직하게는 동결-건조시켜 제공한다.
DNA 서열을 RNA 서열로 전환시키거나(뉴클레오티드의 교환: T->U) 이와 역(뉴클레오티드의 교환: U->T)도 가능하다. 따라서, 하나의 서열을 본 명세서(서열 목록 포함) 중의 DNA 서열로서 제공하는 경우는 언제든 상기를 또한 그의 각각의 RNA 서열 및 이와 역으로서 판독할 것이다. 본 명세서에 사용되는 바와 같이, RNA는 전형적으로 단일-가닥인 반면 DNA 분자는 전형적으로 이중 가닥이다. 그러나, 또한 이중-가닥/단일-가닥 형태의 각각의 RNA/DNA는 본 발명에 청구될 뿐만 아니라 상기 청구된 서열에 상보성인 서열(예를 들어 cDNA)도 청구될 것이다.
적어도 하나 이상, 예를 들어 전체 NA 분자의 길이는 예를 들어 100 내지 1000000 뉴클레오티드, 바람직하게는 130 내지 100000 뉴클레오티드 또는 150 내지 10000 뉴클레오티드일 수 있다.
바람직한 실시태양에서, 상기 천연 또는 인공 유전자는 단백질(예를 들어 mRNA)을 암호화할 뿐만 아니라, 비 단백질-암호화 전사물, 예를 들어 microRNA, snoRNA 또는 rRNA를 포함한 조절 또는 촉매적 RNA뿐만 아니라 그들의 전구체, 특히 전-microRNA 또는 전-rRNA가 고려된다.
본 명세서에 사용되는 바와 같이, "유전자"는 하나 이상의 전사물을 형성하도록 전사되는 서열을 갖는 유전학적 뉴클레오티드에 관한 것이다.
본 명세서에 사용되는 바와 같이, "동형" 또는 "전사물 변이체"는 전사물의 특정 변이체에 관하여 사용된다.
본 명세서에 사용되는 바와 같은 "약"은 동일한 값 또는 주어진 값의 +/-10% 만큼 상이한 값을 지칭할 수 있다.
본 명세서에 사용되는 바와 같은 "포함하다"는 개방된 정의로서 이해될 것이며, 함유하는에서와 같이 추가의 구성원을 허용한다. 다른 한편으로 "이루어지는"은 상기 이루어지는 정의 특징의 추가의 요소 없이 폐쇄된 정의로서 간주된다. 따라서 "포함하다"가 보다 넓은 정의이며 "이루어지는" 정의를 함유한다. "포함하는"이란 용어를 사용하는 본 명세서의 임의의 정의는 또한 본 발명의 특별한 실시태양에서 이루어지는의 제한으로 판독될 수 있다.
상기 핵산 서열분석 단계를 당해 분야에 공지된 임의의 방법, 예를 들어 PCR 서열분석에 의해 수행할 수 있다. 상기와 같은 방법은 막삼-길버트(Maxam-Gilbert) 서열분석, 쇄-종결 방법, 샷건 서열분석, 브리지 PCR, 초병렬 서명 서열분석(MPSS), 폴로니 서열분석, 피로서열분석, 일루미나(Illumina)(솔렉사(Solexa)) 서열분석, SOLiD 서열분석, 이온 반도체 서열분석, DNA 나노볼 서열분석, 헬리스코프 단일 분자 서열분석, 단일 분자 실시간(SMRT) 서열분석, 나노포어 DNA 서열분석, 하이브리드화에 의한 서열분석, 질량 분광분석에 의한 서열분석, 미세유동성 상거 서열분석, 현미경-기반 기법, RNAP 서열분석, 시험관내 바이러스 대량고속처리 서열분석을 포함한다.
본 명세서에 사용되는 바와 같이, "자릿수"는 "십진법 자릿수"를 의미한다, 예를 들어 "6 자릿수"(또한 본 명세서에서 "6 자릿수"라 칭한다)에 걸쳐 있는은 1 내지 1x106 또는 2x10-7 내지 0.2에 걸쳐 있는 값을 의미한다.
임의의 본 발명의 방법 또는 단계를 명백히 제외하는 경우를 제외하고 컴퓨터-실행된 방법으로서 수행할 수 있다. 심지어 대개 NA 분자의 습식-화학 서열분석 및 합성 단계는, 예를 들어 자동 또는 반-자동 서열 판독기로부터 데이터를 조절 및 획득하기 위해서 컴퓨터에 의해 지원될 수 있다. 상기 컴퓨터 프로그램 생성물 또는 기억 장치에 또한, 샘플로부터 짧은 리드를 획득하는 리드 생성 성분, 예를 들어 서열분석기, 바람직하게는 컴퓨터 성분을 포함하는 서열분석기가 제공될 수 있다. 예를 들어, 컴퓨터 판독성 매체는 비제한적으로 자기 저장 장치(예를 들어 하드 디스크, 플로피 디스크, 자기 스트립...), 광학 디스크(예를 들어 콤팩트 디스크(CD), 디지털 만능 디스크(DVD)...), 스마트 카드, 및 플래시 메모리 장치(예를 들어 카드, 스틱, 키 드라이브...)를 포함할 수 있다.
참조 뉴클레오티드 서열에 관하여 "서열 일치성 퍼센트(%)"는, 서열 및 필요한 경우 도입되는 갭을 최대의 서열 일치성 퍼센트를 성취하기 위해 정렬시킨 후에, 상기 서열 일치성의 부분으로서 어떠한 보존적 치환도 고려하지 않은, 상기 참조 서열 중의 뉴클레오티드와 일치하는 후보 서열 중의 뉴클레오티드의 백분율로서 정의된다. 갭은 일치성의 결여를 일으킨다. 뉴클레오티드 서열 일치성 퍼센트의 측정을 위한 정렬을 당해 분야의 기술내에 있는 다양한 방식들, 예를 들어 공개적으로 입수할 수 있는 컴퓨터 소프트웨어, 예를 들어 BLAST, BLAST-2, ALIGN, ALIGN-2, Megalign(DNASTAR) 또는 EMBOSS 소프트웨어 패키지의 "니들" 짝 서열 정렬 어플리케이션으로 성취할 수 있다. 당해 분야의 숙련가들은 비교되는 서열들의 전체 길이에 걸쳐 최대의 정렬을 성취하는데 필요한 임의의 연산을 포함한, 서열 정렬에 적합한 매개변수들을 측정할 수 있다. 그러나, 본 명세서의 목적을 위해서, 뉴클레오티드 서열 일치성% 값을 EMBOSS 소프트웨어 패키지(유럽 분자 생물학 실험실로부터 공개적으로 입수할 수 있다; Rice et al., EMBOSS: the European Molecular Biology Open Software Suite, Trends Genet. 2000 Jun;16(6):276-7, PMID: 10827456)의 컴퓨터 프로그램 "니들"의 서열 정렬을 사용하여 계산한다.
상기 니들 프로그램을 웹 사이트 http://www.ebi.ac.uk/Tools/psa/emboss_needle/nucleotide.html 하에서 접근하거나 또는 http://emboss.sourceforge.net/로부터 EMBOSS 패키지의 부분으로서 로컬 설치를 위해 다운로드할 수 있다. 상기는 다수의 광범위하게 사용되는 UNIX 운영 체계, 예를 들어 리눅스(Linux)상에서 실행된다.
2개의 뉴클레오티드 서열을 정렬하기 위해서, 상기 니들 프로그램을 바람직하게는 하기의 매개변수들로 실행한다:
명령행: needle -auto -stdout -asequence SEQUENCE_FILE_A -bsequence SEQUENCE_FILE_B -datafile EDNAFULL -gapopen 10.0 -gapextend 0.5 -endopen 10.0 -endextend 0.5 -aformat3 pair -snucleotide1 -snucleotide2 (Align_format: pair Report_file: stdout)
주어진 뉴클레오티드 서열 B에, 상기 서열과, 또는 상기 서열에 대한 주어진 뉴클레오티드 서열 A(한편으로 주어진 뉴클레오티드 서열 B에, 상기 서열과, 또는 상기 서열에 대한 일정한 뉴클레오티드 서열 일치성%를 갖거나 포함하는 주어진 뉴클레오티드 서열 A로서 표현될 수 있다)의 뉴클레오티드 서열 일치성%를 하기와 같이 계산한다:
100 x 분수 X/Y
여기에서 X는 A 및 B의 상기 프로그램의 정렬에서 서열 정렬 프로그램 니들에 의해 일치하는 매치로서 기록된 뉴클레오티드의 수이고, Y는 B 중의 뉴클레오티드의 총수이다. 뉴클레오티드 서열 A의 길이가 뉴클레오티드 서열 B의 길이와 동일하지 않은 경우, A 대 B의 뉴클레오티드 서열 일치성%는 B 대 A의 뉴클레오티드 서열 일치성%와 동등하지 않음을 알 것이다. "A의 서열이 B의 전체 서열에 적어도 N% 일치하는" 경우, Y는 B의 전체 길이이다. 달리 구체적으로 진술되지 않는 한, 본 명세서에 사용된 모든 뉴클레오티드 서열 일치성% 값을 상기 니들 컴퓨터 프로그램을 사용하여 바로 앞 단락에 기재된 바와 같이 획득한다.
"서열 유사성", "서열 일치성", "서열을 공유하는" 및 유사한 용어들을 또한 서열의 역 보체에 적용할 것이다, 즉 "서열 A가 서열 B에 80% 일치한다"란 표현은 또한 "서열 A가 서열 B의 역보체(또는 안티센스 서열)에 80% 일치하는" 경우 참일 것이다.
본 명세서에서, NA 서열과 관련하여 "삽입"이란 용어는 또한 5' 또는 3' 단부에서의 직접적인 삽입(즉 5' 또는 3' 단부에서 첨가)을 의미할 수 있다.
예시적인 실시태양
본 발명의 방법의 특히 바람직한 실시태양은
a) 적어도 3개의 상이한 NA 분자 그룹을 포함하고, 이때 각각의 그룹이 적어도 3개의 상이한 NA 분자로 이루어지는, 전사물 변이체를 모방하는 인공 NA 분자의 참조 세트를 제공하고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 모든 NA 분자는 동일한 인공 유전자의 참조 전사물 변이체이고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 NA 분자는 적어도 80 뉴클레오티드(nt) 길이, 바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 특히 적어도 200 nt의 서열을 공유하고, 상기 각 그룹의 적어도 2개의 NA 분자는 적어도 80 nt 길이, 바람직하게는 적어도 100 nt, 보다 바람직하게는 적어도 150 nt, 훨씬 더 바람직하게는 적어도 200 nt, 특히 적어도 300 nt의 적어도 또 다른 서열만큼 상이하며,
여기에서 상기 인공 NA 분자는 각각 소정의 몰량으로 존재하고; 추가로
상기 인공 NA 분자는 각각
- 적어도 100 nt의 길이를 갖고 적어도 하나의 인공 엑손을 포함하며, 여기에서 상기 공유된 서열은 단일 인공 엑손 서열 중에 포함되고,
상기 NA 분자의 참조 세트는
- 25% 내지 55%의 평균 GC 함량을 가지며,
- 하기의 그룹 중에서 선택된 적어도 5개의 선택적인 전사 사건들을 모방하고:
선택적인 전사물 개시 부위(TSS), 선택적인 전사물 종료 부위(TES), 안티센스 전사물, 중복 전사물, 및 스키핑된 카세트 엑손(CE), 인트론 유지(IR), 상호 배타적인 엑손(MXE), 선택적인 3' 스플라이싱 부위(A3SS), 선택적인 5' 스플라이싱 부위(A5SS), 선택적인 첫 번째 엑손(AFE), 선택적인 최종 엑손(ALE) 및 트랜스-스플라이싱의 그룹 중에서 선택된 선택적인 스플라이싱 사건들,
상기 인공 NA 분자의 참조 세트의 엑손 서열의 모든 5' 개시 디뉴클레오티드의 적어도 75%는 GT이며, 상기 인공 NA 분자의 참조 세트의 엑손 서열의 모든 3' 종료 디뉴클레오티드의 적어도 75%는 AT이며,
상기 참조 세트의 서열은 NCBI GenBank 데이터베이스 수납 번호가 표 3 및 표 4 중 어느 하나에 나열된 서열과 유사성을 갖지 않으며, 이때 통계학적 유의수준 한계(예상 한계)는 10 미만이고, 여기에서 상기 유사성을 하기의 매개변수들을 갖는 BLASTn 프로그램에 의해 측정하고: 낮은 복잡성 영역의 필터링, 1차 갭 비용 및 1, -2의 매치/미스매치 점수와 함께 28의 워드 크기인 단계;
b) 상기 참조 세트를 외부 대조군으로서 상기 전사물 변이체를 포함하는 하나 이상의 샘플에 가하는 단계;
c) NA 서열분석을 리드 생성 및 할당을 근거로 수행하고, 여기에서 참조 리드 할당은 상기 참조 세트의 리드에 의해 생성되고 상기 참조 리드 할당을 사용하여 상기 하나 이상의 샘플의 전사물 변이체의 리드 할당을 조절, 확인 또는 변형시키는 단계
를 포함하는, 하나 이상의 샘플 중 전사물 변이체의 조절된 식별 및/또는 정량분석 방법이다.
참고문헌:
도면의 간단한 설명
도 1: SIRV 설계 원리의 개략적인 개관.
도 2: DNA 합성 후 선택된 SIRV의 플라스미드 선형화에 대한 예시적인 결과. 상기 SIRV는 정확한 크기를 가지며 T7 폴리머라제에 의한 RNA 전사에 사용될 수 있다.
도 3: 선택된 SIRV 및 조건에 대한, T7 폴리머라제에 의한 전사 수율에 대한 예시적인 결과. 전사는 대부분의 선택된 조건에 대해서 성공적이었다. o/n, 밤새.
도 4: KLK5 및 SIRV1 그룹 정렬. 도해는 SIRV1 및 상응하는 참조 유전자의 전사물 정렬을 도시한다. SIRV1-100이 마스터 전사물임에 유의한다. SIRV1-101-105는 규정(canonical) 전사물(KLK5 전사물과 유사하게)이다. 전사물 SIRV1-106-109는 인공 전사물이며 이때 후반 3개는 중복(안티센스) 전사물이다. MT = 마스터 전사물.
도 5: LDHD 및 SIRV2 그룹 정렬. 도해는 SIRV2 및 상응하는 참조 유전자의 전사물 정렬을 도시한다. SIRV2-100이 마스터 전사물임에 유의한다. SIRV2-201-204는 규정 전사물(LDHD 전사물과 유사하게)이다. 전사물 SIRV2-205 및 206은 인공 모노엑손 안티센스이다. MT = 마스터 전사물.
도 6: LGALS17A 및 SIRV3 그룹 정렬. 도해는 SIRV3 및 상응하는 참조 유전자의 전사물 정렬을 도시한다. SIRV3-100이 마스터 전사물임에 유의한다. SIRV3-301-306은 규정 전사물(LGALS17A 전사물과 유사하게)이다. 전사물 SIRV3-307-311은 인공 전사물이며 이때 후반 하나는 모노엑손 안티센스 전사물이다. 전사물 SIRV3-308-310은 중복 안티센스 전사물이다. MT = 마스터 전사물.
도 7: DAPK3 및 SIRV4 그룹 정렬. 도해는 SIRV4 및 상응하는 참조 유전자의 전사물 정렬을 도시한다. SIRV4-100이 마스터 전사물임에 유의한다. SIRV4-401-407은 규정 전사물(DAPK3 전사물과 유사하게)이다. 전사물 SIRV4-408-410은 인공 전사물이며 이때 후반 2개는 중복 안티센스 전사물이다. MT = 마스터 전사물.
도 8: HAUS5 및 SIRV5 그룹 정렬. 도해는 SIRV5 및 상응하는 참조 유전자의 전사물 정렬을 도시한다. SIRV5-100이 마스터 전사물임에 유의한다. SIRV5-501-510은 규정 전사물(HAUS5 HAUS 전사물과 유사하게)이다. 전사물 SIRV5-511 및 512는 인공 전사물이며 이때 후반 하나는 모노엑손 안티센스 전사물이다. MT = 마스터 전사물.
도 9: USF2 및 SIRV6 그룹 정렬. 도해는 SIRV6 및 상응하는 참조 유전자의 전사물 정렬을 도시한다. SIRV6-100이 마스터 전사물임에 유의한다. SIRV6-601-615는 규정 전사물(USF2 전사물과 유사하게)이다. 전사물 SIRV6-616-618은 인공 전사물이며 이때 후반 2개는 모노엑손 안티센스 전사물이다. MT = 마스터 전사물.
도 10: TESK2 및 SIRV7 그룹 정렬. 도해는 SIRV7 및 상응하는 참조 유전자의 전사물 정렬을 도시한다. SIRV7-100이 마스터 전사물임에 유의한다. SIRV7-701-707은 규정 전사물(TESK2 전사물과 유사하게)이다. 전사물 SIRV7-708은 인공 전사물이다. MT = 마스터 전사물.
도 11: SIRV 레이아웃. 모든 SIRV 카세트는 XhoI 제한 부위로 출발한 다음, T7 프로모터, 구아노신 및 SIRV mRNA 바디가 이어진다. 모든 SIRV는 그의 3' 단부에 30 아데노신의 폴리-A 꼬리뿐만 아니라 NsiI 제한 부위를 유지하여 런-오프 전사가 가능하다.
도 12: FPKM 상관관계 플롯. 샘플 1 및 샘플 2의 FPKM 값들이 서로에 대해 플롯팅되어 있다.
도 13: 인공 유전자 SIRV 1의 커버리지를 나타내는 게놈 브라우저 스크린샷. SIRV 1 표지된 전사물을 갖는 것은 모두 주어진 어노테이션에 상응한다. 커프스링크는 오차를 도입하는 Cuff.8 및 .9라 명명되는 5개의 전사물 변이체를 추가로 유도한다.
도 14: 믹스(Mix) E0, E1 및 E2를 수득하기 위한 SIRV 혼합 설계. A) 8개의 프리믹스(PreMix)는, SIRV가 바이오분석기 자취에서 분명하게 식별될 수 있도록 길이가 상이한 6 내지 11개의 SIRV를 함유한다. 2개의 프리믹스를 각각 같은 비로 합하여 총 4개의 서브믹스(SubMix)를 제공하였다. 차례로 이들을 한정된 비로 합하여 최종 믹스 E0, E1 및 E2를 수득하였다. 측정된 자취를 적색으로 나타내며, 서브믹스 및 최종 믹스를 확인하기 위해 상기 프리믹스 자취로부터 계산된 자취를 청색으로 나타낸다.
도 15: 대조군을 갖는 RNA. SIRV 믹스를 또한 시험 준비가 된 참조 RNA 샘플 RC-0, RC-1 및 RC-2로서 입수할 수 있다. 첫 번째 샘플, 보편적인 인간 참조 RNA(UHRR, 10개의 혼주(pooled) 암 세포주로부터, 에이질런트 테크놀로지스 인코포레이티드(Agilent Technologies, Inc.))를 ERCC 엑스폴드(ExFold) 믹스 1로 스파이크하고; 두 번째 샘플, 인간 뇌 참조 RNA(HBRR, 23 공여자의 다수의 뇌 영역으로부터, 라이프 테크놀로지스 인코포레이티드)를 ERCC 엑스폴드 믹스 2로 스파이크하고; 세 번째 샘플의 경우 상기 둘을 2:1 비로 합하였다. 이어서 상기 3개 샘플을 SIRV 믹스 E0, E1 및 E2로 스파이크하여 전체 RNA 중의 2% mRNA 함량과 비교된 상대적인 크기로서 평가된 도면에 나타낸 바와 같은 질량비를 획득하였다.
도 16: SIRV NGS 리드를 정확한 어노테이션 SIRV_C로 할당한 결과로서 SIRV의 투입-산출 상관성, A) E1을 함유하는 샘플 RC-1 및 E2를 함유하는 RC-2에서, B) E2와 E1간의 차별적인 발현 비. 개별적인 데이터 점을 작은 회색 기호로 나타내고 평균값을 큰 흑색 기호로 강조한다. 각각의 라인은 표준 편차를 표시한다. 회색 직선은 대각선을 강조한다.
실시예
실시예
1:
SIRV
특징
| 명칭 |
인간
전사물
주형 |
배향 | 엑손 | 길이 | GC 함량 |
서열
번호 |
| SIRV1 그룹 | ||||||
| SIRV101 | KLK5-001 | 센스 | 6 | 1591 | 46% | 1 |
| SIRV102 | KLK5-002 | 센스 | 4 | 1330 | 45% | 2 |
| SIRV103 | KLK5-004 | 센스 | 6 | 1393 | 45% | 3 |
| SIRV104 | KLK5-005 | 센스 | 7 | 1429 | 45% | 4 |
| SIRV105 | KLK5-006 | 센스 | 5 | 700 | 44% | 5 |
| SIRV106 | 주형 없음 | 센스 | 3 | 1003 | 45% | 6 |
| SIRV107 | 주형 없음 | 센스, 중복 | 3 | 774 | 45% | 7 |
| SIRV108 | 주형 없음 | 안티센스, 중복 | 3 | 732 | 46% | 8 |
| SIRV109 | 주형 없음 | 안티센스, 중복 | 3 | 494 | 45% | 9 |
| SIRV2 그룹 | ||||||
| SIRV201 | LDHD-001 | 센스 | 11 | 2081 | 42% | 10 |
| SIRV202 | LDHD-002 | 센스 | 11 | 2001 | 42% | 11 |
| SIRV203 | LDHD-003 | 센스 | 5 | 716 | 41% | 12 |
| SIRV204 | LDHD-004 | 센스 | 3 | 770 | 42% | 13 |
| SIRV205 | 주형 없음 | 안티센스 | 1 | 553 | 42% | 14 |
| SIRV206 | 주형 없음 | 안티센스 | 1 | 454 | 40% | 15 |
| SIRV3 그룹 | ||||||
| SIRV301 | LGALS17A-001 | 센스 | 5 | 2497 | 35% | 16 |
| SIRV302 | LGALS17A-002 | 센스 | 2 | 1837 | 35% | 17 |
| SIRV303 | LGALS17A-004 | 센스 | 3 | 2048 | 35% | 18 |
| SIRV304 | LGALS17A-005 | 센스 | 8 | 1113 | 34% | 19 |
| SIRV305 | LGALS17A-006 | 센스 | 3 | 466 | 32% | 20 |
| SIRV306 | LGALS17A-201 | 센스 | 3 | 2403 | 36% | 21 |
| SIRV307 | 주형 없음 | 센스 | 5 | 809 | 34% | 22 |
| SIRV308 | 주형 없음 | 안티센스, 중복 | 3 | 509 | 41% | 23 |
| SIRV309 | 주형 없음 | 안티센스, 중복 | 3 | 826 | 43% | 24 |
| SIRV310 | 주형 없음 | 안티센스, 중복 | 3 | 619 | 39% | 25 |
| SIRV311 | 주형 없음 | 안티센스 | 1 | 191 | 30% | 26 |
| SIRV4 그룹 | ||||||
| SIRV401 | DAPK3-001 | 센스 | 9 | 2283 | 39% | 27 |
| SIRV402 | DAPK3-004 | 센스 | 3 | 2089 | 37% | 28 |
| SIRV403 | DAPK3-005 | 센스 | 4 | 700 | 38% | 29 |
| SIRV404 | DAPK3-006 | 센스 | 4 | 622 | 38% | 30 |
| SIRV405 | DAPK3-007 | 센스 | 2 | 656 | 40% | 31 |
| SIRV406 | DAPK3-008 | 센스 | 2 | 647 | 42% | 32 |
| SIRV407 | DAPK3-201 | 센스 | 8 | 2135 | 39% | 33 |
| SIRV408 | 주형 없음 | 센스 | 5 | 600 | 36% | 34 |
| SIRV409 | 주형 없음 | 안티센스, 중복 | 3 | 1597 | 44% | 35 |
| SIRV410 | 주형 없음 | 안티센스, 중복 | 2 | 980 | 44% | 36 |
| SIRV5 그룹 | ||||||
| SIRV501 | HAUS5-002 | 센스 | 17 | 1920 | 45% | 37 |
| SIRV502 | HAUS5-003 | 센스 | 18 | 2014 | 46% | 38 |
| SIRV503 | HAUS5-004 | 센스 | 3 | 556 | 43% | 39 |
| SIRV504 | HAUS5-005 | 센스 | 1 | 2503 | 50% | 40 |
| SIRV505 | HAUS5-006 | 센스 | 16 | 2059 | 47% | 41 |
| SIRV506 | HAUS5-007 | 센스 | 2 | 582 | 51% | 42 |
| SIRV507 | HAUS5-008 | 센스 | 6 | 563 | 50% | 43 |
| SIRV508 | HAUS5-009 | 센스 | 17 | 2115 | 46% | 44 |
| SIRV509 | HAUS5-010 | 센스 | 4 | 915 | 47% | 45 |
| SIRV510 | HAUS5-201 | 센스 | 18 | 2504 | 48% | 46 |
| SIRV511 | 주형 없음 | 센스 | 2 | 576 | 51% | 47 |
| SIRV512 | 주형 없음 | 안티센스 | 1 | 259 | 47% | 48 |
| SIRV6 그룹 | ||||||
| SIRV601 | USF2-001 | 센스 | 9 | 1465 | 42% | 49 |
| SIRV602 | USF2-002 | 센스 | 8 | 604 | 41% | 50 |
| SIRV603 | USF2-003 | 센스 | 1 | 1999 | 35% | 51 |
| SIRV604 | USF2-004 | 센스 | 10 | 1567 | 43% | 52 |
| SIRV605 | USF2-005 | 센스 | 9 | 1118 | 43% | 53 |
| SIRV606 | USF2-006 | 센스 | 4 | 575 | 45% | 54 |
| SIRV607 | USF2-007 | 센스 | 4 | 604 | 47% | 55 |
| SIRV608 | USF2-008 | 센스 | 4 | 407 | 35% | 56 |
| SIRV609 | USF2-009 | 센스 | 4 | 515 | 48% | 57 |
| SIRV610 | USF2-010 | 센스 | 5 | 1193 | 39% | 58 |
| SIRV611 | USF2-012 | 센스 | 3 | 484 | 46% | 59 |
| SIRV612 | USF2-013 | 센스 | 10 | 1558 | 43% | 60 |
| SIRV613 | USF2-014 | 센스 | 6 | 1341 | 38% | 61 |
| SIRV614 | USF2-015 | 센스 | 5 | 489 | 40% | 62 |
| SIRV615 | USF2-016 | 센스 | 3 | 813 | 34% | 63 |
| SIRV616 | 주형 없음 | 센스 | 4 | 561 | 45% | 64 |
| SIRV617 | 주형 없음 | 안티센스 | 1 | 306 | 43% | 65 |
| SIRV618 | 주형 없음 | 안티센스 | 1 | 219 | 41% | 66 |
| SIRV7 그룹 | ||||||
| SIRV701 | TESK2-001 | 센스 | 5 | 2492 | 36% | 67 |
| SIRV702 | TESK2-002 | 센스 | 6 | 2277 | 37% | 68 |
| SIRV703 | TESK2-003 | 센스 | 5 | 2528 | 36% | 69 |
| SIRV704 | TESK2-004 | 센스 | 3 | 458 | 29% | 70 |
| SIRV705 | TESK2-201 | 센스 | 5 | 2492 | 36% | 71 |
| SIRV706 | TESK2-202 | 센스 | 5 | 979 | 33% | 72 |
| SIRV707 | TESK2-203 | 센스 | 10 | 2356 | 36% | 73 |
| SIRV708 | 주형 없음 | 센스 | 5 | 919 | 33% | 74 |
또한 도 1, 및 4 내지 10을 참조하시오.
예시를 목적으로, SIRV 전사물 그룹 1 내지 7을 생성시키는 7개의 인공 SIRV 유전자(SIRV1-SIRV7)를 서열번호 149 내지 156에 나열한다. 상기 SIRV 유전자는 상기 유전자가 생성시키는 전사물에 의해 한정되므로, 오직 그의 엑손 서열(즉 상기 전사물 중 적어도 하나에서 엑손인 서열, 상기는 다른 전사물에 대해서는 인트론일 수 있다, 즉 존재하지 않을 수 있다)에 의해서 한정된다. 본 명세서에 언급된 바와 같이, 상기는 오직 개념으로서 존재하는 것으로 충분하다.
상기 SIRV의 엑손을 서열번호 156 내지 334에 나열한다.
SIRV는 뉴클레오티드 및 단백질 수준에 대한 블라스트(blast) 검색에 의해 밝혀진 바와 같이 NCBI 데이터베이스 중의 기입물들과 일치성이 없다. 상기 인공 SIRV 전사체로부터 50 nt 길이 NGS 리드를 생성시키는 인실리코 실험에서 상기 SIRVome는 또한 모델 유기체 인간, 마우스, 아라비도프시스 탈리아나(Arabidopsis thaliana), 씨 엘레간스(C. elegans), 디 멜라노가스터(D. Melanogaster), 이 콜라이(E. Coli)(CGA1.20), 에스 세레비지아에(S. Cerevisiae) 및 엑스 트로피칼리스(X. tropicalis)로부터의 어노테이션된 전사체에 그다지 정렬되지 않고, 상기 SIRVome에 매우 충분히 지도화되었다. 또한, 임의의 표적-밖(off-target) 정렬을 리드 스파이크로서 쉽게 식별할 수 있다. 따라서, 상기 SIRV 전사체는 시험된 모델 유기체 전사물과 매우 상이할 것이며 상기 게놈에서 스파이크-인 대조군으로서 사용시 전사물 발견 및 정량분석을 방해하지 않는 듯하다는 결론이 내려진다. 외삽에 의해, 다수의 상이한 계통적 부류로부터의 게놈들이 상기 nt 블라스트 외에 시험되었기 때문에, 상기 인공 SIRV 서열이 임의의 공지된 게놈 시스템을 방해하지 않을 것임은 합리적으로 추정될 수 있다.
SIRV를 또한, ERCC 스파이크-인 전사물에 대한 표적-밖 지도화가 거의 존재하지 않기 때문에, ERCC와 함께 사용할 수 있다.
상기 74 SIRV 전사물은
·NGS RNA-Seq 실험 및 다른 NA 분석 방법, 예를 들어 마이크로-어레이 분석 또는 qPCR에 스파이크-인 전사물로서 사용될 수 있고,
·매우 낮은 표적-밖 정렬과 함께 SIRVome에 대한 독특한 지도화를 허용하는 인공 서열이고,
·길이, GC 함량, 인트론 스플라이싱 부위 디뉴클레오티드 및 엑손-인트론 구조에 관하여 천연 mRNA를 모방하고,
·ERCC와 함께 사용될 수 있고,
·T7 RNA 폴리머라제 전사물로서 비용-효과적으로 생성될 수 있다.
상기 SIRV는
·폴리-A 기준 선택 및 증폭
·동형 검출,
·어노테이션-기반 동형 지도화 및 가설 형성,
·동형 풍부성 평가,
·로그-변화 배수 확인(다양한 SIRV 농도를 갖는 2개 믹스를 사용함으로써),
·동형 풍부성 평가 연산의 훈련(training) 및 확인,
·동형 드노보 조립,
·SQUARE 시스템(WO 2011/095501 A1에 기재된 복잡성 감소 방법)에서 동형 분리
를 허용한다.
실시예
2:
SIRV
생성
상기 SIRV를 생성시키기 위해서, 시험관내 전사 주형을 외부 DNA 합성 제공기에 의해 합성하였다. 상기 구조물은 5'에서 3'으로 (a) 독특한 제한 부위(XhoI), 바로 상류의 (b) T7 RNA 폴리머라제 프로모터(그의 3' G는 (c) SIRV 서열의 첫 번째 뉴클레오티드이다), 이어서 이음매 없이 (d)(e) 독점적인 NsiI 제한 부위와 융합된 A(30) 꼬리를 포함한다(도 11).
상기 T7 프로모터의 융합뿐만 아니라 상기 A(30) 꼬리내로의 NsiI 부위의 통합은 5' G(SIRV 서열뿐만 아니라 T7 프로모터의 부분)로 시작하여 여분의 3' 뉴클레오티드가 없는 폴리-A 꼬리로 종료하는 서열-참 RNA를 생성시키는 전사를 허용한다.
DNA 합성 제공기는 벡터, 본래의 T7 프로모터 없는 플라스미드 pUC57내로 클로닝된 유전자 카세트를 전달하였다. 2710 bp 길이의 플라스미드 pUC57은 pUC19의 유도체이며 이 콜라이에서 클로닝 벡터로서 통상적으로 사용된다. 상기 벡터는 암피실린 내성에 대한 bla 유전자 및 백색/청색 선택을 위한 lacZ 유전자를 함유한다. GenBank 수납 번호 Y14837.1, 바이오 베이식 인코포레이티드(Bio Basic, Inc.)에 의해 제공된 지도.
제한 및 전사 분석에 충분한 8 내지 10 ㎍의 각각의 벡터를 수용하였다. XhoI 및 NsiI에 의한 이중 절단은 정확한 삽입 크기 및 제한의 완료를 나타낸다.
그러나, 대규모의 예비 전사를 위해서, 상기 SIRV 플라스미드를 50 ㎍ 배치 규모로 생성시켰다.
플라스미드 선형화:
다량의 RNA를 생성시키기 위한 초기 디폴트 방법은 SIRV 발현 카세트를 함유하는 NsiI 제한된 벡터의 런-오프 전사이다. 이를 위해서, 수 ㎍의 상기 플라스미드를 절단하여 정확한 3' 단부를 획득하였다. 완전한 PstI/NsiI 제한은 모든 구조물에 대해서 바이오 베이식에 의해 이미 입증되었지만, 우리는, 전사의 개시가 시험관내 전사 반응의 제한 단계 중 하나이고 심지어 주형 프렙 중 소량의 환상 플라스미드조차 다량의 전사물을 생성시킬 것이기 때문에, NsiI 단독에 의한 효율적인 절단을 검사하였다(도 2 참조).
NsiI 제한은 3'-돌출 단부를 생성시킨다. 이는 두 번째 가닥 전사를 개시시킬 수 있으며, 이 경우에 우리는 상기 접착 단부의 평활화(blunting)에 의지하였다. 이를 위해서, T4 DNA 폴리머라제의 3'-5' 엑소뉴클레아제 활성을 사용하였다.
에피센터 앰플리스크라이브 키츠 하이일드 앤드 플래시(Epicentre AmpliScribe Kits High Yield and Flash)를 사용하는 T7 전사:
상기 선형화된 전사물을 상업적인 T7 전사물 키트, 에피센터의 앰플리스크라이브 T7 하이일드 전사 키트(Art.No 150408) 및 앰플리스크라이브 T7 플래시 전사 키트(Art.No 150405)에서 주형으로서 사용하였다.
T7 전사를 지배하는 주요 인자는 고 dNTP 농도를 허용하는 전사 조건을 갖는 키트의 사용이다. 이는 고수율을 허용한다, 즉 1 ㎍ 플라스미드는 160 내지 180 ㎍ 이하의 RNA를 생성시킬 수 있다(예를 들어 에피센터의 하이일드 키트).
더욱 또한, 절대 한계까지, 보다 많은 주형은 보다 많은 RNA를 생성시킬 것이다. 다양한 길이의 주형을 위해서, 몰농도를 고려해야 하며, 짧은 주형은 전사 개시가 제한 단계이고 T7 폴리머라제 연장의 한 단계가 600 nt까지 포함하므로(에피센터의 웹사이트로부터의 정보) 보다 긴 것과 동일한 질량의 RNA를 생성시키지는 않을 것이다.
보다 긴 배양 시간은 상기 개시 가능성을 증가시키고, 보다 짧은 주형의 수율에 보다 큰 영향을 미친다. 따라서 때때로 표준 2시간이 아니라 4 내지 6시간 또는 심지어 밤새 배양하는 것이 권장된다. 그러나, 보다 긴 배양은 상기 T7 전사 완충제가 Mg2 + 양이온을 함유하기 때문에 RNA 분해를 생성시킬 수 있다.
상기 T7 전사효소 반응 온도를 37 ℃에서 42 ℃로 증가시키면 수율이 강하게 증가할 수 있다. 이는 보다 복잡한(GC-풍부, 구조화된) 주형의 경우 현저할 수 있다(도 3 참조).
미량의 GuSCN, 페놀, SDS, RNA 또는 금속 이온은 T7 전사효소 활성을 억제할 수 있다. 예를 들어 와트만 정제에 의한 상기 선형화된 플라스미드의 엄격한 정제가 권장된다. 한편으로, 상기 반응 부피를 증가시키거나 또는 상기 플라스미드 투입 부피를 낮출 수 있다.
주형 DNA를 DNase에 의해 제거해야 한다. 에피센터(앰플리스크라이브 매뉴얼)에 따라, 1 단위의 상기 포함된 DNase를 37 ℃에서 15분 동안 추가로 배양하면서 상기 전사에 직접 가할 수 있다. 상기 DNase 처리를 RNA 완전성에 대한, 즉 상기가 잔류 RNase로 인해 RNA를 분해시키는지에 대한 영향에 대해 시험할 것이다. 한편으로, DNA를 또한 SPLIT 프로토콜 변이체에서 산성 페놀 추출에 의해 제거할 수 있다. 그러나, GuSCN은 후속의 실리카 컬럼 결합에 필요하지 않을 수도 있다.
남아있는 플라스미드 DNA를 생물분석기 실행(심지어 RNA-특이성 염료와 함께)에서 또는 -정량적으로- qPCR 분석에서 프라이머 GCTAATACGACTCACTATA*G (서열번호 337) 및 TTTTTTTTTTTTTTTTTTTTTTTTT*V (서열번호 338)를 사용하여 검출할 수도 있으며, 이때 (*)는 포스포티오에이트 결합을 갖는 뉴클레오티드이다.
권장된 SIRV 정제 방법을 하기에 기재한다. PAGE: NGS 스파이크-인 전사물에 필요한 높은 품질의 시험관내 전사된 RNA를 정제하기 위한 표준 프로토콜은 PAGE 용출이나, 상기는 성가시며 그다지 정확하지 않고, UV 가교결합을 유도할 수도 있고, >1 kb 전사물에는 적합하지 않다.
실리카-기반 정제:
정제를 처음에는 단지 핵산으로부터 dNTP, 첨가제 및 단백질을 제거하는 것으로 당해 분야의 모든 숙련가에게 공지된 와트만 프로토콜에 의해 수행할 것이다. 그러나, 상기 과정은 손실 경향이 있으며; 시험 마커의 60% 이하가 상기 표준 과정에서 용출되지 않았다. 또한, 상기 DNA 주형이 함께 용출될 것이다. 용출 완충제 EB 또는 저장 완충제 SB가 효율적인 용출에 사용될 수 있는지를 시험해야 한다.
전사물의 자기 올리고(magnetic oligo)(dT) 비드 정제:
전사 반응이 완전길이 RNA(NsiI 제한 부위까지)를 생성시키지 못하는 경우, 상기 RNA는 A(30)-꼬리를 함유하지 않을 것이다. 따라서, 올리고(dT) 비드 정제를 사용하여 완전-길이 전사물을 선택적으로 정제할 수 있다. 그러나, 상기 방법은, 상기 RNA가 또한 상기 A(30)-신장부의 최소 하나의 사본을 함유하기 때문에, 예행 전사(run-through) 또는 두 번째 가닥 전사에 의해 생성된 이상(aberrant) RNA를 구분하지 못할 것이다. 상기 DNA 주형의 하나의 가닥이 또한 상기 폴리-A 신장부를 함유할 것임에 유의한다. DNA가 그의 dsDNA 형태로 존재하는지의 여부(상기 전사물이 그의 주형으로부터 방출되기 때문에) 및 올리고(dT) 하이브리드화에 참여할 수 없는지를 결정할 필요가 있다. 상기 방법의 하나의 변형에서 상기 올리고는 RNA일 것이며, 상기 결합 단계에 이어서 RNase H 절단, 그의 암호화된 A(30) 신장부를 통해 비드에 결합된 임의의 플라스미드 DNA의 제거가 이어질 수 있다. 한편으로, 상기 DNA를 DNase 처리에 의해 제거한다.
피핀 프렙(pippin prep):
세이지 사이언티픽 피핀 프렙(Sage Scientific Pippin prep)은 1.5% 또는 2% 고유 아가로스 카세트로부터 dsDNA(예를 들어 NGS 라이브러리)를 용출시키기 위해 고안된 자동화된 젤 용출 시스템이다. RNA는 상기 피핀 프렙의 외부 또는 내부 DNA 표준에 따라 실행되지 않으므로, 길이 평가가 가능하지 않다. 그럼에도 불구하고, 충분한 순도의 SIRV는 설정 한계 염기쌍 값 뒤의 다음 피크를 자동적으로 수집하는 크기 선택 프로토콜 "피크"에 의해 검출될 수 있는 단일의 주요 피크로 진행한다.
품질 조절 및 정량분석은 SIRV 혼합물의 생성에 중요하다. 나노드롭 정량분석: 광도계 측정은 A260/A230 및 A260/A280 비 형태로 농도(및 따라서 수율) 및 순도를 제공한다. 중요하게, 불충분한 정제는 나노드롭 장비(나노드롭 인스트루먼츠)에서 수행되는 바와 같은 흡광도 측정이 미량의 dNTP를 또한 측정하기 때문에(이는 260 ㎚에서 과도한 흡광도를 갖는다) 흡광도 측정으로서 문제가 있다. 큐빗(Qubit) 측정(라이프테크놀로지스)을 세 번째 참조로서 취할 수 있다.
에이질런트 생물분석기 RNA 나노칩:
상기 SIRV 전사물을 올바른 길이, 양, RNA 완전성(즉 파괴 또는 분해 산물) 및 이상(보다 긴) 생성물에 대해서 에이질런트 생물분석기 RNA 칩상에서 평가할 수 있다.
변성 젤 전기영동:
상기 생물분석기에 상보적으로 RNA를 또한 그의 크기에 따라 변성 PAA 또는 아가로스 젤상에서 분석할 수 있다. 이는 전사물 길이의 보다 정확한 평가를, 정량분석 및 상기 생물분석기에 의해 제공된 범위 없이 가능하게 할 수 있다.
qPCR:
상기 스파이크-인 전사물의 완전성을 평가하고 상보적인 정량분석을 유도하기 위해서, 완전-길이 cDNA 합성에 이어서 상기 전사물의 5', 중간 및 3' 영역에 위치한 다중 앰플리콘의 qPCR을 수행할 수 있다. 외부 표준으로서, 상기 PCR 전사 주형을 동일한 셋업에서 증폭시킬 수 있다. 이러한 셋업을 또한 SIRV 믹스 중의 상대적인 농도의 측정에 적용할 수 있다.
이들 SIRV-특이성 프라이머를 오직 하나의 특이적인 SIRV 각각을 표적화하고 예를 들어 주어진 유전자의 모든 SIRV에 공통적인 엑손은 표적화하지 않도록 조심스럽게 설계할 필요가 있다.
실시예
3:
RNA
-
seq에서
외부 대조군으로서
SIRV의
용도
하기의 단계 i) 샘플 수집, ii) RNA 정제, iii) NGS 라이브러리 생성, iv) NGS 서열분석, v) 참조 어노테이션에 대한 리드 정렬 및 vi) 후속의 생물정보학 처리로 이루어지는 실험 과정이 상대적인 전사물 풍부성을 계산하는 것으로 널리 추정된다. 그러나, 하기의 실시예에 나타내는 바와 동일한 실험 데이터 세트의 상이한 방법들, 예를 들어 상이한 샘플 제조 및 또한 생물정보 처리 루틴이 또한 가능하다.
부분적으로 확인된 전사물 풍부성을 함유하는 단지 매우 작은 데이터 세트를 입수할 수 있다. 상기 중 하나는 마이크로-어레이 품질 조절(MAQC) 샘플(MAQC Consortium, 2006)로부터의 것이고 보편적인 인간 참조 RNA(UHRR) 및 인간 뇌 참조 RNA(HBRR)를 함유한다. 상기 두 RNA 샘플 모두에 대해서 qPCR 측정이 1044 Taqman 탐침으로 유도되었다. 상기 측정치를 수납 번호 GSE5350하에서 유전자 발현 옴니버스로부터 입수할 수 있다. 또한, 상기 UHR 및 뇌 RNA 샘플을 일루미나 게놈애널라이저(Illumina GenomeAnalyzer)의 7개 레인상에서 서열분석하여, 35 bp 단일-단부 리드를 생성시켰다(James et al., 2010). 상기 리드(NCBI 리드 기록 보관소로부터 수납번호 SRA010153으로 입수할 수 있다)를 Ensembl 어노테이션 GRCh37 버전 75에 대해 톱햇2로 지도화하였다. 상기 1044개 Taqman 탐침으로부터 오직 906개 탐침만이 유지되었으며, 이를 GSE5350에 따라 단일 Refseq 어노테이션에 대해 지도화한다. 상기 Ensembl 어노테이션이 상기 실험에 사용되었기 때문에 상기 Taqman 탐침 세트는 Ensembl 중에 특유의 당량을 갖도록 Taqman 탐침의 Refseq 어노테이션을 요청함으로써 추가로 감소되었다. 최종적으로, 상기 894개 Taqman 탐침으로부터, 오직 Ensembl 전사물 어노테이션이 다수의 전사물을 갖는 유전자내에 함유된 것들만이 사용되었다. 그 결과 최종적으로 798개 Taqman 탐침 세트가 생성되었다. Pennseq(Hu et al., 2014), 방법 1, 및 편향 보정되거나 보정되지 않은 커프스링크, 방법 2 및 3(Roberts et al., 2011; Trapnell et al., 2010)을 사용하여 상기 798개 전사물상에서 FPKM 값 형태로 농도 평가를 유도하였다.
상기 상이한 방법들에 의해 획득된 FPKM 값과 qPCR 값 사이의 상관성을 표 7에 나타낸다. 상기 상관성을 로그 공간에서 R2 값 및 스피어맨 상관성 ρ로 측정한다. 0에 가까운 값은 로그 공간에서 통계학을 현저하게 왜곡시킬 수 있기 때문에, 1e-3 이하의 FPKM 값을 상기 모든 방법들에 대해서 1e-3으로 설정한다. 한편으로, 1e-3 이하의 FPKM을 갖는 전사물은 검출되지 않은 것으로 간주할 수 있다.
| R2 | ρ | ND % | ND avg log10 (qPCR) | |
| Pennseq | 0.418 | 0.7129 | 2.79 | -1.6506 |
| 커프스링크 | 0.3317 | 0.6541 | 15.48 | -1.6801 |
| 편향 보정된 커프스링크 |
0.3943 | 0.7312 | 14.61 | -1.7606 |
표 7에 나타낸 바와 같이, 상기 R2 값은 한편으로 Pennseq의 경우 0.418이고, 편향 보정되지 않은 커프스링크의 경우 0.3317이며 편향 보정된 커프스링크의 경우 0.3943이다. 다른 한편으로, 상기 스피어맨 상관성은 Pennseq의 경우 0.7129이고, 편향 보정되지 않은 커프스링크의 경우 0.6541이며 편향 보정된 커프스링크의 경우 0.7312이다. 현저하게, 편향 보정된 및 보정되지 않은 커프스링크는 qPCR에 의해 존재하는 것으로 입증된 전사물의 14.61% 및 15.48%를 검출하지 않는 반면, Pennseq는 각각 2.79%를 검출하지 않는다. 중요하게, 상기 3개의 계산 방법에 의해 측정되지 않은 전사물은 qPCR 확인 실험에서 -1.65 내지 -1.76의 높은 평균 log10 풍부성을 가졌다.
본 실시예는 2개의 상이한 생물정보학적 연산, 및 2개의 상이한 편향 보정을 갖는 것(커프스링크)이 3개의 현저하게 상이한 결과를 생성시킨다는 하나 초과의 Ensembl 전사물 어노테이션을 함유하는 798개 Taqman qPCR 확인된 유전자좌의 선택을 통해 설명한다. 상기 정렬은 다수의 유전자내의 리드를 잘못된 전사물로 분배한다. 절대 상관성은 지면 저점(ground trough)을 우리가 알지 못하기 때문에 불가능하다. 오직 천연 유전자 중의 전사물과 유사한 복잡한 환경에 존재하는 공지된 풍부성을 갖는 인공 전사물 변이체만이, 상기가 개별적인 단계든 전체 작업공정이든, 측정 방법 정확성의 정량적인 평가를 가능하게 한다.
실시예
4: 랜덤 분포를 시험하기 위한
카이
-제곱 검정
예로서, "GAA, GAC, GAG, GAT, GCA, GCC, GCG, GCT, GGA, GGC, GGG, GGT, GTA, GTC, GTG, GTT 중에서 선택된 5' 개시 트리뉴클레오티드의 필수적으로 랜덤하게 분포된 존재를 갖는 인공 전사물 서열의 세트"에 대한 카이-제곱 검정을 어떻게 적용하는지에 대해 설명할 것이다.
별개의 경우, 또는 세포의 수(n): 16 (GAA, GAC, GAG, GAT, GCA, GCC, GCG, GCT, GGA, GGC, GGG, GGT, GTA, GTC, GTG, GTT)
인공 전사물 서열의 수(N): 74
5' 개시 뉴클레오티드(O1, O2, O3, ..., On)의 존재(수):
GAA 5
GAC 5
GAG 4
GAG 6
GAT 3
GCA 2
GCC 4
GCG 5
GCT 6
GGA 7
GGC 4
GGG 3
GTA 4
GTC 5
GTG 6
GTT 5
자유도(df): n - p = 15(별개의 균일한 분포의 경우 p = 1)
임의의 세포에 대한 예상 존재는 (별개의 균일한 분포의 귀무가설하에서) Ei = N/n = 4.625이다. 이는 트리뉴클레오티드의 (완벽한) 균일한 분포를 갖는 세트가 허위로 5' 개시 트리뉴클레오티드로서 4.625의 각각의 상기 언급된 트리뉴클레오티드를 가짐을 의미한다.
카이-제곱(피어슨의 누적 검정 통계학)을 하기와 같이 정의한다:
상기에서 상기 식에 직접 적용된 Oi, Ei 및 n에 대한 값은 카이-제곱 = 5.57을 생성시킨다
일정한 카이-제곱 값(본 실시예에서 5.57) 및 일정한 자유도(본 실시예에서 15)에 대한 확률값("p 값")을 주지된 표(소위 카이-제곱 표)에 표로 나타낸다. 상기 p 값을 또한 널리 사용되는 사무용 소프트웨어, 예를 들어 마이크로소프트 엑셀, 리브레오피스 또는 오픈오피스(이들 중 후반 2개는 무료로 입수할 수 있다)에 의해, 또는 무료로 입수할 수 있는 R 소프트웨어 패키지로 계산할 수 있다. 마이크로소프트 엑셀 2003의 영문 버전에서, 상기 기능을 CHIDIST라 칭한다.
카이-제곱 = 5.57 및 df = 15와 관련된 p 값은 0.9861이다. 따라서, 본 실시예에서 개시 뉴클레오티드의 존재는 본 명세서에 정의된 바와 같은 "필수적으로 랜덤하게 분포된다"는 조건을 충족시킨다.
실시예
5:
SIRV
평가
서열번호 1 내지 74에 의해 제공된 상술한 세트로부터의 74개 SIRV 중 60개를 합성하고, 클로닝하고, 발현시키고, 정제하고, 품질 조절하고 전기영동 측정(RNA 나노 및 피코 칩 및 생물분석기(에이질런트)에서의 분석)을 통해 농도를 측정한 후에 2개의 마스터 믹스로 합하고 추가의 샘플 제조를 위해 10 ng/㎕ 이상의 농도로 농축시켰다. SIRV 믹스 1은 동일한 질량으로 모두 60개의 SIRV를 함유하였다. SIRV 믹스 2를 1:10:100의 랜덤화된 비로 102 배 이하까지 SIRV 유전자내 개별적인 SIRV의 양을 변화시킨 혼합 설계에 따라 제조하였다. 상기 SIRV 믹스 2에서 각각의 SIRV 유전자는 모든 부차적인 SIRV들의 합으로서 동등한 질량으로 제공되었다.
3개의 RNA 샘플을 제조하였다. 샘플 1은 단지 일반적인 SIRV 전사물 혼합물 SIRV 믹스 1(100 ng)만을 함유하였다. 샘플 2는 500 ng의 보편적인 인간 참조 RNA(에이질런트)를 0.3 ng ERCC(앰비온) 및 3 ng SIRV 믹스 1과 합하였다. 샘플 3은 500 ng 의 보편적인 인간 참조 RNA(에이질런트)와 0.3 ng ERCC(앰비온) 및 3 ng SIRV 믹스 2로 이루어졌다.
상기 3개의 mRNA 샘플을, 샘플 제조를 수행하고 서열분석을 수행하는 서비스 제공자(파스테리스(Fasteris), 스위스 소재)에게 선적하였다. NGS 라이브러리를 폴리A 선택 없이 맞춤 라이브러리 제조에 의해 샘플 1로부터 제조한 반면, 샘플 2 및 3은 폴리A 선택과 함께 일루미나 가닥 mRNA 라이브러리 제조를 겪었다. 3개의 라이브러리 모두 바코드를 붙였고, 의도된 균등한 비로 혼합하였다. 서열분석을 v3 화학물질을 갖는 일루미나 MiSeq상에서 수행하였으며 150 bp의 색인이 달린 리드가 생성되었다.
종합해서, 26.7 Mio 리드가 생성되었고 주어진 바코드로 할당될 수 있었다. 상기 리드의 품질을 FastQC(v0.11.1)로 평가하였다. 일부 어댑터 오염이 검출되었으며 이를 하기의 매개변수: ./bbduk.sh ... ktrim = r k=28 mink=12 hdist=1 minlength=20을 갖는 bbmap 스위트(버전 32.32)로부터 bbduk를 사용하여 손질할 수 있었다. 상기 생성 리드를 Ensembl의 GRCh 37.75, 앰비온의 ERCC92 및 SIRVome의 결합된 전사체 및 게놈 참조 어노테이션에 대해 톱햇(v.2.0.8)으로 지도화하였다. 상기 지도화 통계학을 표 8에 나타낸다.
| 전체 리드 | 지도화 리드 | [%] | 특유의 지도화 리드 | [%] | |
| 샘플 1 | 10,246,442 | 8,585,641 | 83.79 | 8,505,344 | 83.01 |
| 샘플 2 | 10,119,416 | 8,642,852 | 85.41 | 8,399,336 | 83.00 |
| 샘플 3 | 6,308,855 | 5,404,486 | 85.67 | 5,268,757 | 83.51 |
상이한 어노테이션에 걸친 특유의 지도화 리드의 분포를 표 9에 제공한다. 샘플 2 및 샘플 3에서 하기의 리드 비 70.3:2.7:27의 UHRR:ERCC:SIRV가 중량 투입에 따라 예상되었으며 전체 RNA 중 2% mRNA 함량이 추정되었다.
| GRCh37.75 | ERCC92 | SIRV | ||||
| 샘플 1 | 4,330 | 0.05% | 11 | 0.00% | 8,505,555 | 99.949% |
| 샘플 2 | 7,521,308 | 89.55% | 38,031 | 0.45% | 839,997 | 10.00% |
| 샘플 3 | 4,156,399 | 78.89% | 22,207 | 0.42% | 1,090,151 | 20.69% |
샘플 1에서, 전체 리드의 99.94%의 매우 높은 수가 SIRVome로 지도화된 반면 단지 0.06%만이 인간 게놈 전체 및 ERCC로 지도화되었다. 상기 결과는 상기 SIRVome와 다른 공지된 서열과의 높은 부적합성 및 SIRV 서열의 독특함을 입증한다.
샘플 2 및 3에서, 상기 92 ERCC 중 58 및 52가 모든 리드의 0.45 및 0.42%에 상응하게 검출되었다. 중량 기준으로 상기 가중된 3% 이하의 ERCC 리드의 반복되는 과소-표시는 단지 24 아데노신의 비교적 짧은 폴리-A 꼬리 및 잠재적으로 가수분해되거나 또는 달리 단편화되고 폴리-A 선택되고 고갈된 ERCC에 기인한다. 상기 SIRV를 상기 ERCC에 비해 10배 접근으로 상기 샘플에 혼합하였으며, 상기는 30개 아데노신의 보다 긴 폴리-A 꼬리 및 상기 SRIV의 잠재적으로 보다 높은 완전성에 의해 야기된 10 및 20.7% 및 따라서 20- 내지 40-배 접근을 따라잡았다.
상기 지도화된 리드를 IGV 게놈 브라우저를 사용하여 시각적으로 검사하였다. 편향 보정된 커프스링크(v.1.3.0)를 사용하여 상기 전사물 풍부성을 평가하였다. 모든 SIRV 전사물을 FPKM 값>0으로 검출하였다. 0.8 이하의 R2 값을 갖는 투입-산출 상관성은, 광범위한 품질 측정이 삽입성 형광 염료를 사용하는 예비 모액 농도 측정 외에 다수의 독립적인 수단에 의해 지면 저점 투입 농도를 확인하기 위해 필요함을 입증한다. qPCR 및 Taqman 분석은 상기 농도의 각각의 확인을 위해 준비 중이다.
도 12는 샘플 2 대 샘플 1의 커프스링크 계산된 상대적인 농도 값의 상관성을 도시한다. 샘플 2의 SIRV 농도는 물론 UHRR 및 ERCC 배경으로 인해 대략 10배 더 낮다. 그럼에도 불구하고, 0.95 이상의 높은 R2 값이 예상될 수 있었는데, 그 이유는 일치하는 SIRV 믹스 1이 상기 두 샘플 모두에서 측정되었기 때문이다. 부분적으로 거짓인 리드 할당은 도 13에 도시된 바와 같이 생물정보학적 처리에 의해 야기된다.
SIRV 유전자 1에 대한 전체적인 커버리지를 도 13의 상부 열에, 하기의 식별된 어노테이션된 전사물 SIRV 101 내지 109(모두 SIRV1으로 암호화됨)와 함께 나타내나, 단 SIRV 믹스 1에서 74개 SIRV 중 60개의 부분이 아니고 따라서 상기 어노테이션에 포함되지 않는 105는 제외한다. 커프스링크는 추가적인 전사물 가설을 더하고 리드를 내부적으로 한정된 길이 의존성 확률 분포 및 다른 다수의 할당 규칙에 따라 전사물 변이체의 세트로 할당하였기 때문에, 제공된 값들은 0.83의 R2 값을 갖는 샘플 1 및 2 사이의 SIRV 상관성이 일치하는 샘플들에 대해 낮을 때 단순히 정확하지 않다.
상기 수행된 할당 오차의 평가를 위해서 오직 상기 제공된 SIRV 참조 세트에 의해서만 가능한 투입 농도의 지면 저점을 아는 것이 필수적이다. 상기 주어진 모델 복잡성에서 오직 상기 투입-산출 상관성의 분석만이 상기 측정의 정확성에 관한 가정을 미지의 전사물 변이체의 전체 세트에 대해 외삽할 수 있게 하며, 이는 본 발명에 의해서 처음으로 가능하다.
실시예
6: 한정된 농도 및 농도비를 갖는
SIRV
믹스
E0, E1, 및 E2의 제조, 및
RNA
샘플
RC
-0,
RC
-1 및
RC
-2를 스파이크하기 위한
SIRV
믹스의
용도
여기에서, 상기 74개 SIRV 중 69개 SIRV를, 모세관 전기영동 생물분석기 자취에서 정확하게 계산된 크기의 주 피크 중 ≥85 w/w%를 나타냄으로써 한정된 바와 같은 순도로 획득된 것으로서 선택하였다.
상기 SIRV 용액을 흡광도 분광학(나노드롭, 써모 사이언티픽)에 의해 측정하고 모액 농도를 ≥50 ng/㎕로 조절하였다. 260 ㎚ 대 280 ㎚ 및 260 ㎚ 대 230 ㎚에서의 흡광도 비는 상기 RNA의 최고 순도를 가리키며 하기와 같이 기록되었다:
A260 nm / 280 nm
2.14 ± 0.12,
A260 nm / 280 nm
2.17 ± 0.20
상기 나노드롭은 정확한 RNA 정량분석을 허용하며, 제조사의 명세서에 따른 오차는 ≤100 ng/㎕ 핵산 샘플의 경우 ±2 ng/㎕이다. 50 ng/㎕ 부근의 최종 SIRV 모액 농도 측정의 정량분석에 대한 상대적인 오차는 ±4%이다.
각 용액의 몰농도를 하기에 따른 SIRV 서열의 기본 분포를 근거로 계산하였다:
MW [g/mol] = A*329.2+U*306.2+C*305.2+G*345.2+159
8개의 프리믹스를 동몰비로 6 내지 11개의 SIRV 전사물을 함유하도록 설계하였다. 이들의 길이 분포는 도 14A에 나타낸 바와 같이 생물분석기 자취에서의 특유의 식별을 허용하여 상기 프리믹스 및 후속의 믹스 중 SIRV의 존재 및 완전성을 모니터할 수 있게 한다(도 14B 및 C). 상기 생물분석기 자취는 절대적인 정량분석을 허용하지 않지만, 상기를 사용하여 상대적인 화합물 분포 및 상기 혼합 과정의 일관성을 추적하였다.
상기 8개 프리믹스의 정확한 부피측정 제조를 계산된 표적 농도로부터 0.002%±3.4%(최대 7.6%)의 편차를 갖는 나노드롭 농도 측정에 의해 조절하였다. 상기 부피의 혼합을 분석 저울상에서의 칭량에 의해 추가로 모니터하였으며, 이는 1.8%±0.65%(최대 2.5%)의 편차를 보였다.
상기 8개의 프리믹스를 짝을 이루어 합하여 4개의 서브믹스를 제공하였다. 상기 혼합 과정을 도 14B에 나타낸 바와 같이 전기영동에 의해 품질 모니터하였다. 상기 4개의 서브믹스의 부피측정 제조를 나노드롭 농도 측정(0.8%±2.5%, 최대 4.5%의 편차)에 의해 조절하였다.
상기 4개의 서브믹스를 한정된 부피측정비로 최종 믹스에 합하였으며, 전기영동에 의한 상기 혼합 과정의 모니터링을 도 14C에 나타낸다. 상기 4개의 서브믹스를 최종 믹스 E0에 합하는 비는 1:1:1:1이었으며, 최종 믹스 E1의 경우 1/4:1/2:2:1이고, 최종 믹스 E2의 경우는 4:1/4:1/32:1이었다. 나노드롭 농도 측정은 상기 계산된 표적 농도로부터 5.1%±3.3%(최대 8.6%)의 편차를 나타내었다.
매우 좁은 여유분 내에서, 믹스의 모든 생물분석기 자취는 그들 각각의 프리믹스 및 서브믹스 구성성분들의 합을 닮는다(도 14). 상대적인 피크 모양 및 위치는 SIRV 믹스에 대한 신뢰성 있는 정량적인 모니터링 도구이다.
이러한 수단에 의해서 신뢰성 있는 SIRV 농도 및 농도비가 상이한 혼합물들에서 보장될 수 있다.
SIRV 믹스 E0, E1 및 E2를 사용하여 보편적인 인간 참조 RNA(UHRR) 및 인간 뇌 참조 RNA(HBRR)(또한 ERCC 대조용 믹스 1 및 2를 함유하여 대조용 RC-0, RC-1 및 RC-2를 갖는 참조 RNA를 생성시켰다)를 스파이크하였다. 상기 각 RNA 분획의 상대적인 양을 도 15에 나타내며 이는 상기 UHRR 및 HBRR 중의 전체 RNA의 2%의 일정한 mRNA 함량을 근거로 계산되었다. 상기 스파이크-인, SIRV 및 ERCC 믹스의 최종의 상대적인 농도는 상기 참조 RNA의 진정한 mRNA 함량뿐만 아니라 리보솜 및 다른 매우 풍부한 RNA의 양을 감소시키면서 고갈 및/또는 농축시키는 방법에 따라 변한다. 이러한 샘플은 상이한 RNA-Seq 워크 플로우(work flow)를 시험하기 위해 고안되었다.
실시예
7:
NGS
서열분석,
SIRV
믹스를
갖는 RNA 샘플
RC
-1 및
RC
-2의 데이터 평가 및 상이한
어노테이션을
사용함에 의한 상기 RNA 서열분석 파이프라인의 정확성의 측정
폴리-A-꼬리가 없는 SIRV 분자의 서열번호 1 내지 74 및 모든 엑손의 서열번호 156 내지 334의 서열들은 임의의 공통의 어노테이션 파일 포맷으로 전치될 수 있는 순수한 SIRV 서열들이다. 하나의 상기와 같은 예는 모든 엑손, 인트론 및 상기 첫 번째 및 마지막 엑손에 인접하고 번역되지 않은 영역들라 지칭되는 서열의 순수한 뉴클레오티드 서열을 나열하는 FAS-TA-파일, 및 각 엑손의 개시 및 종료 좌표에 관한 정보를 보유하는 상응하는 GTF-파일의 조합이다. 서열번호 156 내지 334 서열을 인간 모델 유전자의 배향에 상응하는 가닥 배향으로 전치하였으며, 모든 인트론 서열을 각각의 길이의 GC-가중된 랜덤 서열로 충전하였으며 이때 모든 인트론 공여체-수용체 부위는 표 2에 나타낸 바와 같은 규정 및 비-규정 공여체 수용체 쌍에 대한 그들의 상대적인 존재에 상응한다. 서열번호 339 내지 345(7개 서열을 갖는 FASTA 파일을 나타낸다)는 상기 완전한 엑손 및 인트론 서열을 1 kb 길이 상류 및 1 kb 길이 하류 서열과 함께 함유한다. 상기 GTF 파일은 상기 변이체 구조에 관한 정보를 함유하며 하기의 변화를 예로서 제공한다, GTF 파일 "SIRV C"(부록 B에 나열됨)는 믹스 E1 및 E2 중에 있는 모든 SIRV의 정확한 어노테이션을 함유한다. GTF 파일 "SIRV I"(부록 A에 나열됨)는 불충분한 어노테이션의 다수의 가능성들 중 하나이다. 여기에서, 믹스들 중에 실제로 존재하는 일부 SIRV는 어노테이션되지 않는다. GTF 파일 "SIRV O"(부록 C에 나열됨)는 무한한 수의 가능한 과-어노테이션 중 하나이다. 추가적인 SIRV가 어노테이션되며, 이들은 믹스 중에 존재하지 않는다. 본문에서 상기 어노테이션의 변화를 SIRV_C, SIRV_I 및 SIRV_O라 칭한다.
상기 SIRV를 사용하는 데이터 평가의 가능성은 다양하다. 하기의 제안은 RNA-Seq 파이프라인의 수행성능을 평가하기 위해 수행되어야 하는 기본적인 과정을 개략한다. 역다중화, 바코드 및 품질 손질 후에, 리드를 각각의 게놈, SIRVome(모든 SIRV 서열 전체), 및 적용 가능한 경우 ERCC 서열에 지도화해야 한다. 상기 SIRVome에 지도화되는 모든 리드를 여과하여 별도로 처리할 수 있다.
리드의 유전자 부류에 대한 할당은 상기 스파이크-인 과정의 변화성에 관한 첫 번째 개관을 제공한다. 상기 SIRV 함량은 그의 예상되는 질량 또는 몰비율과 관련이 있어야 한다. RNA 분자의 길이를 포함하고 FPKM과 같은 척도에 이르기 위한 라이브러리 제조의 경우 SIRV 리드의 비율은 질량비에 따라야 하는 반면, 어느 한 태그가 독립적으로 RNA 분자를 카운트하는 라이브러리 제조의 경우 상기 SIRV 리드는 몰비에 따라야 한다. 샘플-특이적인 편향의 보정은 차별적인 발현(DE) 분석에 중요하다. RNA 샘플 배경, mRNA 농도 및 완전성의 변화, 및 고갈 및/또는 mRNA 농축 과정의 변화는 서열분석된 라이브러리 중에 상이한 SIRV 믹스 함량을 유도한다. 전체 RNA 샘플의 mRNA 함량은 2.5 이하 또는 그 이상의 인자만큼 변할 수 있다. 상기와 같은 편향의 보정은 차별적인 발현의 정확한 시험, 및 후속적으로 RNA 샘플 자체 중의 상기 DE 측정의 상대화 및 보정에 중요하다. 상쇄 인자(offset factor)는 RNA 부류 분포의 척도이며 SIRV 대조군-기반 표준화에 사용될 수 있다. 상기 SIRV 믹스의 조심스러운 정량적인 스파이크-인 과정은 필수적인 선결요건이며 샘플 정량분석에 하류인 정확한 부피측정 샘플 처리를 요한다. 모든 측정 및 후속적인 정규화는 작은 부피 규모로 실행시 성취가능한 피펫팅 정확성과 같은 명백한 실험 변수와 관련하여 설정될 필요가 있다.
일례로 NGS 라이브러리의 3중 복제물을 TruSeq 스트랜디드 mRNA 라이브러리 프렙 키트(일루미나, 인코포레이티드)를 사용하여 RC-1 및 RC-2의 500 ng 투입 RNA로 생성시킨 후에 6개의 바코딩된 라이브러리를 HiSeq 2500상에서 공칭 125 bp 길이의 짝진 단부 서열분석 실행으로 서열분석하여, 각각 RC-1 3중 복제물의 경우 16.27±0.16 Mio 손질된 유지된 짝진 단부 리드, 및 RC-2 3중 복제물의 경우 16.97±1.45 Mio를 획득하였다. 상기 리드를 톱햇2로 인간 참조 게놈, ERCC 서열 및 SIRV 서열에 대해 지도화하였다. 상기 SIRV에 속하는 리드의 상대량은 샘플 RC-1에서 2.32±0.05%, 및 샘플 RC-2에서 1.87±0.12%인 것으로 측정되었다.
도 15에서, 스파이크-인 SIRV의 비는 전체 RNA 중 추정된 2% 평균 mRNA 함량에 대해 보다 양호한 비교를 위해 제공된다. 그러나, 진정한 mRNA 함량은 가변적인 것으로 공지되어 있다. 상기는 UHRR에서 3% 및 HBRR에서 2%에 가까운 것으로 이전에 측정되었다(Shippy et al., 2006). mRNA 비 HURR/HBRR은 1.5인 것으로 예상된다.
샘플 RC-2의 참조 RNA 배경은 RC-0 참조 RNA 배경의 2/3 및 RC-1 참조 RNA 배경의 1/3을 함유하기 때문에 상기 RC 샘플 RC-1 및 RC-2 중 2개 SIRV 측정은 상기 UHRR 참조 RNA(샘플 RC-0 중; 상기 참조) 중의 mRNA 함량을 계산할 수 있게 한다. 상기 SIRV는 샘플 RC-1에 2% mRNA에 비해 2.53%로 스파이크되었고, 2.32%로 측정되었으며 이는 HBRR mRNA 함량이 2.18%인 값을 생성시키며, 샘플 RC-2 중의 mRNA 함량은 2.89%이고, 이는 3.44%로 상기 UHRR mRNA에 대해 계산된 값을 유도한다. 상기 mRNA 비 UHRR/HBRR은 1.58인 것으로 측정되며, 이는 1.5의 앞서 공개된 비를 증명한다. 상기 SIRV는 폴리(A30)-꼬리가 상기 사용된 mRNA NGS 라이브러리 제조의 일부인 폴리-A-농축 방법에서 정량적인 표현에 충분함을 입증하는 스파이크된 비를 근거로 100%에 가깝게 나타난다.
커프스링크2 연산에 의한 SIRV 리드의 할당을 SIRV_C 어노테이션을 사용하여 수행하였다. 상기 풍부성은 리드 할당을 기반으로 계산되었고 공지된 투입량과 관련될 수 있다. 투입-산출 상관성을 대수 공간에서 계산하였으나, 상기 세트 농도 범위가 RC-1에서 단지 10배이고 RC-2에서 102 배에 걸쳐 있기 때문에 선형 공간에서도 또한 계산할 수 있었다. 피어슨 적률상관계수, 피어슨의 r은 정확한 측정을 위해서 1에 접근해야 한다. 상기 상관성 플롯을 도 16A에 나타낸다. 상기 r-값은 샘플 RC-1에서 SIRV에 대해 0.446이고, 샘플 RC-2에서 SIRV에 대해 0.932이다(표 10을 참조하시오).
동일한 서브믹스로부터 기원하는 12 내지 21개 전사물의 동몰 농도는 유의수준 품질 척도로서 평균 및 분산을 계산할 수 있게 한다. 각각의 SIRV 믹스에 대해서 상기 서열분석 파이프라인의 품질은 상응하는 분산과 함께 4개의 상대적인 평균값의 세트로서 입증될 수 있다. 상기 검정된 파이프라인에 대한 결과는 각각 RC-1의 경우 1.21±56.05%, 0.93±46.56%, 0.97±49.46%, 및 1.02±71.62%이고, RC-2의 경우 1.56±75.75%, 0.93±54.83%, 0.94±44.46%, 및 1.02±54.48%이다. 상기 상대적인 평균은 전체 농도 범위에 걸쳐 1에 가깝지만, 높은 분산은 개별적인 SIRV가 큰 분산으로 측정됨을 입증한다.
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| 2 | 상대적인 농도 | RC -1 | RC -2 | RC -2/1 | |||||
| 3 | 및 농도비 | 평균 | 표준편차 | 평균 | 표준편차 | 평균 | 표준편차 | ||
| 4 | SIRV_C | 69/69 | 1 | 1 | |||||
| 5 | 1/64 | 0.02 | 0.04 | 0.07 | |||||
| 6 | 1/32 | 0.03 | 0.05 | 0.04 | |||||
| 7 | 1/4 | 0.25 | 0.30 | 0.17 | 0.23 | 0.13 | |||
| 8 | 1/2 | 0.50 | 0.46 | 0.22 | 0.54 | 0.22 | |||
| 9 | 1 | 1 | 0.97 | 0.48 | 0.94 | 0.42 | 1.00 | 0.16 | |
| 10 | 2 | 2 | 2.03 | 1.45 | |||||
| 11 | 4 | 4 | 4.09 | 2.23 | |||||
| 12 | 8 | 8 | |||||||
| 13 | 16 | 16 | 12.44 | 2.92 | |||||
| 14 | r-값 | 0.466 | 0.932 | 0.851 | |||||
| 15 | SIRV_I | 44/69 | 0.62 | 0.67 | |||||
| 16 | meas | 0.77 | 0.81 | ||||||
| 17 | 1/64 | 0.02 | 0.09 | 1.75 | |||||
| 18 | 1/32 | 0.03 | 0.10 | 0.12 | |||||
| 19 | 1/4 | 0.25 | 0.22 | 0.12 | 0.40 | 0.61 | |||
| 20 | 1/2 | 0.50 | 0.34 | 0.22 | 1.09 | 1.42 | |||
| 21 | 1 | 1 | 0.98 | 0.42 | 0.70 | 0.51 | 0.81 | 0.75 | |
| 22 | 2 | 2 | 1.45 | 1.17 | |||||
| 23 | 4 | 4 | 2.93 | 1.43 | |||||
| 24 | 8 | 8 | |||||||
| 25 | 16 | 16 | 13.09 | 0.40 | |||||
| 26 | r-값 | 0.407 | 0.813 | 0.889 | |||||
| 27 | SIRV_O | 100/69 | 1.00 | 1.00 | |||||
| 28 | meas | 1.05 | 1.03 | ||||||
| 29 | 1/64 | 0.02 | 0.03 | 0.89 | |||||
| 30 | 1/32 | 0.03 | 0.05 | 0.04 | |||||
| 31 | 1/4 | 0.25 | 0.30 | 0.16 | 0.23 | 0.12 | |||
| 32 | 1/2 | 0.50 | 0.45 | 0.20 | 0.56 | 0.55 | |||
| 33 | 1 | 1 | 1.00 | 0.57 | 0.97 | 0.49 | 1.02 | 0.28 | |
| 34 | 2 | 2 | 2.16 | 1.65 | |||||
| 35 | 4 | 4 | 4.18 | 2.07 | |||||
| 36 | 8 | 8 | |||||||
| 37 | 16 | 16 | 13.07 | 0.32 | |||||
| 38 | r-값 | 0.507 | 0.699 | 0.871 | |||||
가장 정확하고 재현가능한 평가는 차별적인 발현값 또는 변화배수를 측정함으로서 실현될 수 있다. 상기 믹스는 4개의 서브믹스의 정확한 부피측정 조합에 의해 제조되었기 때문에, 격차는 상기 SIRV의 완전-길이 완전성과 같은 다른 품질 척도에 의해 영향을 받지 않는다. 예상 및 측정된 변화배수간의 비교를 도 16B에 나타내며, 평균 값은 마찬가지로 표 10, 컬럼 9, 5 내지 13열에 나타낸다. 상응하는 분산과 함께 상대적인 평균값은 2.82의 오프셋 및 ±169.9%의 분산과 함께 1/64의 비에서 출발하여, 1.07±41.0%, 1.00±16.2 및 0.78±23.5%까지 계속되는 값들을 나타낸다. 상기 r-값은 0.851에 도달하였다. 비교적 큰 분산은 개별적인 SIRV의 거짓 측정, 및 NGS 파이프라인에 의한 주요한 불일치 정량분석이 유의수준의 변화를 도출하고, 따라서 올바른 정량분석에서 불확실성을 도출함을 암시한다. 큰 분산은 이미 일부 SIRV가 상기가 속하는 서브믹스의 주요 분획에 비례하지 않게 행동함을 암시한다. 4개의 상기와 같은 명백한 예를 SIRV 그룹 1 및 2에서 볼 수 있으며(표 11 참조), 다른 SIRV 그룹들에서 더 많이 볼 수 있다. 한편으로 SIRV 101, 102, 103, 106, 107, 109, 203, 204 및 205의 차별적인 유전자 발현은 상기 세트 비와 10% 미만만큼, SIRV 206의 경우는 15% 미만만큼 상이한 반면, 다른 한편으로 SIRV 105, 108 및 202의 비는 40% 초과만큼, SIRV 201의 비는 250%만큼 상이하다. 대다수 종의 비는 정확하며 4개의 상이한 서브믹스 모두에서 자명하다. 따라서, 명백한 편차는 라이브러리 생성, 서열분석 및/또는 데이터 분석에서 만들어진 오차에 의해 발생한다.
지도화를 상이한 어노테이션 SIRV_I 및 SIRV_O를 사용하여 반복하였다. 버전 SIRV_I(불충분한 어노테이션 이하)는 새로운 전사물 변이체를 검출하는 파이프라인의 능력을 판단할 수 있게 한다. 상기 실험은 어노테이션되지 않은 SIRV의 리드가 어떻게 상기 정량분석을 왜곡하는 어노테이션된 부분집합에 가짜로 분포되는지를 나타낸다. 상기 유도된 농도에서 변화 정도는 RNA-Seq 파이프라인의 확고함(robust)에 대한 추가적인 척도를 제공한다. 본 실험의 경우 상관성 플롯은 저하된다. 상기 r-값은 샘플 RC-1에서 SIRV의 경우 0.406, 및 샘플 RC-2에서 SIRV의 경우 0.813으로 떨어진다. 추가적인 오차는 균일하게 확대되는 듯하며 예상 및 측정 변화 배수간의 비교는 심지어 0.889의 약간 더 높은 r-값을 보인다.
상기 과-어노테이션된 버전 SIRV_O는 세 번째 상황을 반영한다. 여기에서, 상기 샘플들 중에 실제로 함유된 것보다 많은 SIRV가 어노테이션된다. 상기 어노테이션은 예를 들어 다른 조직, 동일한 조직이지만 상이한 발생 단계에서 발견될 수도 있거나, 거짓으로 어노테이션되었거나, 또는 보다 초기 실험에서의 잔존생물인 전사물 변이체를 포함하며, 이 경우 전형적인 길이의 클로닝된 EST를 갖는 다수의 변이체가 전형적인 예이다. 이제, 리드를 실제로 상기 실제 샘플의 부분이 아닌 SIRV 변이체로 할당할 수 있다. 본 실험의 경우 상기 상관성 플롯은 RC-1의 경우 0.506 및 RC-2의 경우 0.699의 r-값을 나타낸다. 상기 예상 및 측정 변화 배수간의 비교는 0.871의 유사한 r-값을 나타낸다.
올바른 SIRV 검출의 정도 및 확고성은 상기 파이프라인 수행성능에 대한 척도이다.
RNA-Seq 실험에서 정확성 수준의 측정을 SIRV 스파이크-인 대조군을 사용하여 상이한 방식으로 수행할 수 있다. 임의의 다른 천연 유전자와 마찬가지로, SIRV 유전자의 변이체는 특유의 증명 서열(telling sequence) 범위에서 상이한 정도에 따라 변한다. 상기 서열 독특성은 NGS 리드를 전사물 변이체로 할당시 해결해야 하는 "단순한" 및 "보다 어려운" 임무의 조합을 포함하는 유전자의 복잡성에 대한 척도이다. 어노테이션과 관련하여 하나의 전사물의 특정한 숫자는 상대적인 변이체 특이성 서열, RSS(뉴클레오티드 수준에 따라 카운트되며 그의 길이에 대해 표준화된다)이다. 각각의 전사물에 대해 공유된 뉴클레오티드 수는 경쟁하는 전사물 변이체의 수에 역비례한다. 서열 복잡성 C에 대한 척도는 전사물의 길이, L로 나눈 모든 역 RSS 값의 합이다. 측정 농도 대 스파이크-인 농도의 상대 편차 배수, D는 이제 상기 서열 복잡성에 의해 가중될 수 있다. 상기 전사물 변이체에 대한 올바른 리드 할당의 도전은 상기 어노테이션의 근원적인 복잡성에 비례한다. 상기 서열 복잡성 C를 곱한, 로그-편차 배수, D의 역 모듈러스(inverse modulus)는 하기에 따른 농도 크기의 가중된 정확성에 대한 척도, A이다:
ASIRV = f1{(Σ(1/RSS))/L}/ f2{|log2 D|} = f1{C}/ f2{|log2 D|}
상기 2개의 함수, f1 및 f2는 상이한 성분들의 증량, 및 예를 들어 상대적인 편차가 1에 접근하고, 따라서 로그가 0에 접근하며 몫이 한정되지 않는 경우 상기 측정 농도 및 스파이크-인 농도의 완벽한 조화를 허용하는 경계 조건의 한정을 허용한다. 결과적으로 상기 SIRV_O 어노테이션내의 모든 69개 SIRV의 올바른 측정은, 정확한 농도 크기를 획득하는 것은 본질적으로 보다 어렵기 때문에, 상기 SIRV_C 어노테이션내에서와 같이 보다 높은 값에 도달할 수 있다. 변화 배수는 주어진 한계와 함께 할당되어야 하는데, 그렇지 않으면 0에 가까운 값이 의미 있는 데이터 평가를 왜곡하기 때문이다.
상대적인 변이체 특이성 서열, RSS 및 복잡성, C를 하나의 예에서 SIRV1의 출발시 중복 서열을 살펴봄으로써 설명할 수 있다. SIRV107은 중복 센스 전사물인 반면 SIRV108 및 109는 중복 안티센스 전사물이다. 어노테이션 SIRV_I에서 SIRV109의 서열은 SIRV108이 생략되기 때문에 독특하며, 각 뉴클레오티드의 모든 1/RSS 값은 1이고, SIRV109의 길이를 곱하고 나누어도 상기 값은 여전히 1이다. 어노테이션 SIRV_C에서 SIRV109의 서열은 SIRV108과 그의 서열의 일부를 공유하므로 더 이상 독특하지 않다. 상응하는 1/RSS 값은 2이고, 복잡성은 >1이다. 어노테이션 SIRV_O에서 SIRV109의 서열은 오직 SIRV108과만 그의 서열의 일부, 오직 SIRV110과만 그의 서열의 일부(이때 상응하는 1/RSS 값은 다시 2이다), 및 상기 둘 다와 그의 서열의 일부(이때 상응하는 1/RSS 값은 3이다)를 공유하는 반면, 그의 서열 중 어느 것도 독특하지 않다. 여기에서, SIRV109의 C-값은 다시 보다 크다. SIRV109의 가중된 정확성, A는 상기 C 값에 비례하고 믹스 E1 및 E2의 공지된 SIRV109 투입으로부터 측정된 log2-편차 배수의 모듈러스에 역비례한다.
상기 변화 배수는 추가로 차별적인 발현의 소환시 참 및 거짓 양성률, TP 및 FP와 같은 다수의 매개변수들을 계산할 수 있게 한다. 상기 TP 대 FP 곡선 아래 면적, AUC는 차별적인 발현 분석에서 진단학적 수행성능을 위한 척도로서 간주될 수 있다.
실시예
8: 신뢰성 있는 적용을 위한
SIRV
및 다른 대조용
분액의
희석, 안정화 및 제조
RNA는 RNase 또는 2가 양이온 및 온도에 의해 가속화되는 가수분해에 의해 분해되기 쉽다. 더욱이, RNA는 다수의 표면에 의해 흡착되는 경향이 있다. 따라서, 전기영동 젤 또는 ERCC 믹스용 RNA 사다리와 같은 RNA 대조군은 산화방지제 및 첨가제, 예를 들어 EDTA, DDT, RNasin 또는 다른 RNase 억제제를 함유하는 완충제 중에 25 ng/㎕ 이상의 농도로 제공된다. 상기와 같은 RNA 용액은 전형적으로 -20 ℃의 심부 온도에서 보관된다. RNA에의 비교를 위해 낮은 백분율 범위로 상기 RNA 대조군을 사용하는 경우, 픽토그램의 수십 배의 분액이 필요하며, 고농축 대조군은 스파이크-인에 적합하기 위해 다양하게 희석되어야 한다. 단지 몇 개의 샘플을 한 번에 처리할 필요가 있는 경우, 상기 희석된 대조군의 대부분을 배치해야 한다. 분액의 희석 및 제조는 불필요한 변화를 도입시킬 위험이 있다.
본 실시예에서 SIRV를 사용하기 쉽게, 주어진 실험에 필요한 총량의 안정한 분액으로 제조한다. 상술한 E0, E1, E2 또는 SIRV 단독 또는 추가적인 RNA 대조용과의 임의의 다른 조합과 같은 SIRV 믹스를 젠테그라(GenTegra)-RNA(젠테그라), RNAstable(바이오매트리카(Biomatrica)), 또는 상기 용액을 건조시키면서 RNA의 분해를 감소시키는 다른 첨가제와 같은 안정화제를 함유하는 무-RNase 완충제를 사용하여 모액으로부터 1 pg/㎕, 10 pg/㎕ 또는 100 pg/㎕로 희석한다. 이어서, 상기 희석된 RNA 대조군을 갖는 용액을 목적하는 양의 분액으로 바이알을 통해 나눈 후에 상기 용액을 주변 온도에서 빠르게 건조시키거나 동결건조시킨다. 상기 분액을 시간 독립적으로 나중의 적용으로부터 제조하는 경우 분액의 수뿐만 아니라 부피도 비교적 클 수 있으며, 이는 상기 대조용의 제조 재현성을 증가시킨다. 상기 대조용 RNA의 건조된 분액들을 실온에서 보관할 수 있다.
상기 대조용 RNA 분액이 필요한 경우, 표적 RNA 샘플을 단지 임의의 가공 단계에서 상기 건조된 대조용 RNA에 첨가하기만 하면 된다. 수 분 정도로 짧은 배양 시간이 상기 건조된 RNA 대조군을 해결하는데 필요하다. 이러한 수단에 의해 상기 샘플은 상기 RNA 대조군에 신뢰성 있게 스파이크된다.
하나의 바람직한 예에서 상기 RNA 대조군은 바코드 서열과 같은 특유의 식별자를 갖는 RNA를 함유한다. 상기 바코드 서열은 상기 바코드 서열의 존재를 표시하는 특유의 인공 서열이 측면에 인접해 있다. 상기 대조군 중의 바코드는 상기 RNA 샘플이 상기 대조군에 첨가되는 순간부터 상기 샘플이 내부 바코드로 독특하게 식별됨을 보증한다. 상기 내부 바코드와 외부 샘플 표지의 매치는 고속대량처리 환경에서 확실히 잘못 보지 않게 한다.
임의의 서열분석 실험에서 상기 대조용 RNA 및 바코드의 존재는 상기 샘플의 추적 및 샘플 처리의 비교가능성을 보장한다.
실시예
9: 서열-특이성 연결 편향을 설명하는 micro-RNA와 같은 추가적인 스파이크-인 대조용과
SIRV와의
조합
SIRV를 ERCC, 상기 언급한 바코드 RNA, 또는 인공 micro-RNA와 같은 다른 RNA 대조군과 결합시킬 수 있다. micro-RNA는 전형적으로 21 내지 23 nt 정도로 짧은 RNA이다. 제한된 크기로 인해 micro-RNA 라이브러리 제조의 작업 흐름은, 프라이밍 및 cDNA 합성이 방해/영향을 받기 때문에 상이하다. 상기 micro-RNA는 직접적으로 직접 연결되어야 한다. 말단 서열 및 특히 소수의 개시- 및 종료-부위는 105 정도로 클 수 있는 강한 편향을 도입시키는 원인이다. 따라서, 연결 반응에서 서열 편향의 측정을 허용하는 특별한 micro-RNA 대조군이 필요하다.
여기에서, 우리는, 우세하게는 21 내지 23 nt 길이이나 16 nt만큼 짧고 36 nt만큼 길 수 있는 서열의 종료뿐만 아니라 개시에서 4, 5 및 8 이하 랜덤 뉴클레오티드, N(8)의 랜덤 서열을 갖는 인공 micro-RNA를 사용한다. 상기 인공 micro-RNA는 합성된다. 본 발명에서 주된 장애물은 A, U, G 및 C의 혼합물이 또한 임의의 합성 편향을 보상하는데 사용되고 miRNA 합성 실행시 작은 변화가 뉴클레오티드 분포에 현저한 변화를 유도할 수 있으며, 이는 차례로 편향을 평가하는데 사용되기 때문에 엄격하게 조절되어야 한다는 것이다. 따라서, 상기 인공 micro-RNA는 또한 중간 부분에 몇몇 랜덤 뉴클레오티드, N을 적어도 하나 내지, 개시-부위의 N과 종료-부위의 N 사이의 최대의 N의 수로 또한 함유한다.
상기 중간의 N은 상기 뉴클레오티드의 분포에서 무작위성의 독립적인 척도를 제공하는 반면, N의 신장부에서 개시- 및 종료-부위의 N은 상기 micro-RNA 라이브러리 제조의 서열 편향을 측정할 수 있게 한다.
SEQUENCE LISTING
<110> Lexogen GmbH
<120> Methods and products for quantifying RNA transcript variants
<130> IPA161585-AT
<150> EP14176417.5
<151> 2014-07-09
<160> 345
<170> BiSSAP 1.3
<210> 1
<211> 1591
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<213> Artificial Sequence
<220>
<223> transcript variant
<400> 1
gcttgtccgc gagtgtcaac cgggttttac aaaggagaac ttccaacatc agtgtatggg 60
atgtttcaaa cacccccaga gacggagaca atagtgtggt cacgtacatt taggaagata 120
aaaataacaa caacagaagg tgtgaggcgc aaggtacatg ctcttacccc actctcagca 180
cgtagggagc ggagtgtgga agaccaacaa gcccgtcgcc tctaccaaat acagctatcc 240
tgaggtgcca ggttagaata ggccctacca catctaagcc ttgaaacggt ctgttcctcg 300
tgtcaagttc tttgtccgct tataccgcca tctctcgttg tggtacaaga gttggttact 360
ctcagtccca ttcccaacac atcactgaga agtatagagc ctagtggtca ttagaaggtc 420
aacatggagt aggtgtttag gtgtgtcgga gggcagaaac caacgaaaga aaggaaacga 480
tcaacactta tatagtgtcc tgtcgggccc aaatcctaag agaccttagg tttaccacat 540
tagtactaaa cagcctgttg tataccgtga gcccccactt cgatctgtaa atggtaatcc 600
cttgtaaaac ctcatctcca aaaacagtat acgcaggtac agctgatgtg atcctctcta 660
ctagtcttct ctgaggaacc atgagatgga tagtggggga cctgagtcat actagggtaa 720
cttcttatat ggtgacatca ctcctaccgt agagggggga cggtagtctg tgggaaatct 780
accctagtga agaaaggtaa gagaatgtct gaacattacc tgtagacgaa ggtactctca 840
gaacaactac tctcacatac ggaaaggttt gggtccttgg tcaaaggact ttactgactc 900
tgcagacgat gaatatctga accaacacta ctatcaaaga tgttcgacta gacctctcgt 960
ggtagggcct ggaagtcaaa agacttctct atgggtacta ggtaggtagt tagagtacgg 1020
tccctggggt gtctcagagt cgaacgttcg ggggaagttc ctaaacatgt taggatgtta 1080
tgataacaag tccaaacgtg gacgtcgtcg ctgtcacctc tcggaacact agctgaggtg 1140
gcttaaaaac attccgtaac tgagtggtca ccgggggtga aacatgctga gggttctacc 1200
ttaacgggaa ggtgaaactc tccaatgtct ttgaaaggac tagttgagat aacccaaacc 1260
gaatccggag gaagaggaga acttggaaaa cgttgtacga cgtcattaat aacgattccg 1320
ttcttcccgt tcgtgtctat aaggatattc tttcattgcg aaggtaagcc cttttgggtc 1380
tagatacgga ctatactcaa aaacccacag accttccact tggagttgtt ttaggagacg 1440
gagtagtaga gaaaacttgt ggcaccttcc cagtcggttc cctacagact ctccttagta 1500
gctcctaaga tcgtcgagtt acacgacgac attgttccga ctgacgtaga ggcattactt 1560
taaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 1591
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gtacaagagt tggttactct cagtcccatt cccaacacat cactgagaag tatagagcct 60
agtggtcatt agaaggtcaa catggagtag gtgtttaggt gtgtcggagg gcagaaacca 120
acgaaagaaa ggaaacgatc aacacttata tagtgtcctg tcgggcccaa atcctaagag 180
accttaggtt taccacatta gtactaaaca gcctgttgta taccgtgagc ccccacttcg 240
atctgtaaat ggtaatccct tgtaaaacct catctccaaa aacagtatac gcaggtacag 300
ctgatgtgat cctctctact agtcttctct gaggaaccat gagatggata gtgggggacc 360
tgagtcatac tagggtaact tcttatatgg tgacatcact cctaccgtag aggggggacg 420
gtagtctgtg ggaaatctac cctagtgaag aaaggtaaga gaatgtctga acattacctg 480
tagacgaagg tactctcaga acaactactc tcacatacgg aaaggtttgg gtccttggtc 540
aaaggacttt actgactctg cagacgatga atatctgaac caacactact atcaaagatg 600
tcgtaggttt gtgagaaggg agaagaagtg gttgagaagt tggtgttcca caagttaaag 660
tagacatacc tttagtacct gtaaaggttc gactagacct ctcgtggtag ggcctggaag 720
tcaaaagact tctctatggg tactaggtag gtagttagag tacggtccct ggggtgtctc 780
agagtcgaac gttcggggga agttcctaaa catgttagga tgttatgata acaagtccaa 840
acgtggacgt cgtcgctgtc acctctcgga acactagctg aggtggctta aaaacattcc 900
gtaactgagt ggtcaccggg ggtgaaacat gctgagggtt ctaccttaac gggaaggtga 960
aactctccaa tgtctttgaa aggactagtt gagataaccc aaaccgaatc cggaggaaga 1020
ggagaacttg gaaaacgttg tacgacgtca ttaataacga ttccgttctt cccgttcgtg 1080
tctataagga tattctttca ttgcgaaggt aagccctttt gggtctagat acggactata 1140
ctcaaaaacc cacagacctt ccacttggag ttgttttagg agacggagta gtagagaaaa 1200
cttgtggcac cttcccagtc ggttccctac agactctcct tagtagctcc taagatcgtc 1260
gagttacacg acgacattgt tccgactgac gtagaggcat aaaaaaaaaa aaaaaaaaaa 1320
aaaaaaaaaa 1330
<210> 3
<211> 1393
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 3
gtgaggcttg tccgcgagtg tcaaccgggt tttacaaagg agaacttcca acatcagtgt 60
atgggatgtt tcaaacaccc ccagagacgg agacaatagt gtggtcacgt acatttagga 120
agataaaaat aacaacaaca gaaggtacaa gagttggtta ctctcagtcc cattcccaac 180
acatcactga gaagtataga gcctagtggt cattagaagg tcaacatgga gtaggtgttt 240
aggtgtgtcg gagggcagaa accaacgaaa gaaaggaaac gatcaacact tatatagtgt 300
cctgtcgggc ccaaatccta agagacctta ggtttaccac attagtacta aacagcctgt 360
tgtataccgt gagcccccac ttcgatctgt aaatggtaat cccttgtaaa acctcatctc 420
caaaaacagt atacgcaggt acagctgatg tgatcctctc tactagtctt ctctgaggaa 480
ccatgagatg gatagtgggg gacctgagtc atactagggt aacttcttat atggtgacat 540
cactcctacc gtagaggggg gacggtagtc tgtgggaaat ctaccctagt gaagaaaggt 600
aagagaatgt ctgaacatta cctgtagacg aaggtactct cagaacaact actctcacat 660
acggaaaggt ttgggtcctt ggtcaaagga ctttactgac tctgcagacg atgaatatct 720
gaaccaacac tactatcaaa gatgttcgac tagacctctc gtggtagggc ctggaagtca 780
aaagacttct ctatgggtac taggtaggta gttagagtac ggtccctggg gtgtctcaga 840
gtcgaacgtt cgggggaagt tcctaaacat gttaggatgt tatgataaca agtccaaacg 900
tggacgtcgt cgctgtcacc tctcggaaca ctagctgagg tggcttaaaa acattccgta 960
actgagtggt caccgggggt gaaacatgct gagggttcta ccttaacggg aaggtgaaac 1020
tctccaatgt ctttgaaagg actagttgag ataacccaaa ccgaatccgg aggaagagga 1080
gaacttggaa aacgttgtac gacgtcatta ataacgattc cgttcttccc gttcgtgtct 1140
ataaggatat tctttcattg cgaaggtaag cccttttggg tctagatacg gactatactc 1200
aaaaacccac agaccttcca cttggagttg ttttaggaga cggagtagta gagaaaactt 1260
gtggcacctt cccagtcggt tccctacaga ctctccttag tagctcctaa gatcgtcgag 1320
ttacacgacg acattgttcc gactgacgta gaggcattac tttaaaaaaa aaaaaaaaaa 1380
aaaaaaaaaa aaa 1393
<210> 4
<211> 1429
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 4
gttttacaaa ggagaacttc caacatcagt gtatgggatg tttcaaacac ccccagagac 60
ggagacaata gtgtggtcac gtacatttag gaagataaaa ataacaacaa cagaagcctt 120
gaaacggtct gttcctcgtg tcaagttctt tgtccgctta taccgccatc tctcgttgtg 180
gtacaagagt tggttactct cagtcccatt cccaacacat cactgagaag tatagagcct 240
agtggtcatt agaaggtcaa catggagtag gtgtttaggt gtgtcggagg gcagaaacca 300
acgaaagaaa ggaaacgatc aacacttata tagtgtcctg tcgggcccaa atcctaagag 360
accttaggtt taccacatta gtactaaaca gcctgttgta taccgtgagc ccccacttcg 420
atctgtaaat ggtaatccct tgtaaaacct catctccaaa aacagtatac gcaggtacag 480
ctgatgtgat cctctctact agtcttctct gaggaaccat gagatggata gtgggggacc 540
tgagtcatac tagggtaact tcttatatgg tgacatcact cctaccgtag aggggggacg 600
gtagtctgtg ggaaatctac cctagtgaag aaaggtaaga gaatgtctga acattacctg 660
tagacgaagg tactctcaga acaactactc tcacatacgg aaaggtttgg gtccttggtc 720
aaaggacttt actgactctg cagacgatga atatctgaac caacactact atcaaagatg 780
ttcgactaga cctctcgtgg tagggcctgg aagtcaaaag acttctctat gggtactagg 840
taggtagtta gagtacggtc cctggggtgt ctcagagtcg aacgttcggg ggaagttcct 900
aaacatgtta ggatgttatg ataacaagtc caaacgtgga cgtcgtcgct gtcacctctc 960
ggaacactag ctgaggtggc ttaaaaacat tccgtaactg agtggtcacc gggggtgaaa 1020
catgctgagg gttctacctt aacgggaagg tgaaactctc caatgtcttt gaaaggacta 1080
gttgagataa cccaaaccga atccggagga agaggagaac ttggaaaacg ttgtacgacg 1140
tcattaataa cgattccgtt cttcccgttc gtgtctataa ggatattctt tcattgcgaa 1200
ggtaagccct tttgggtcta gatacggact atactcaaaa acccacagac cttccacttg 1260
gagttgtttt aggagacgga gtagtagaga aaacttgtgg caccttccca gtcggttccc 1320
tacagactct ccttagtagc tcctaagatc gtcgagttac acgacgacat tgttccgact 1380
gacgtagagg cattacttta aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 1429
<210> 5
<211> 700
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 5
gcgcaaggta catgctctta ccccactctc agcacgtagg gagcggagta caagagttgg 60
ttactctcag tcccattccc aacacatcac tgagaagtat agagcctagt ggtcattaga 120
aggtcaacat ggagtaggtg tttaggtgtg tcggagggca gaaaccaacg aaagaaagga 180
aacgatcaac acttatatag tgtcctgtcg ggcccaaatc ctaagagacc ttaggtttac 240
cacattagta ctaaacagcc tgttgtatac cgtgagcccc cacttcgatc tgtaaatggt 300
aatcccttgt aaaacctcat ctccaaaaac agtatacgca ggtacagctg atgtgatcct 360
ctctactagt cttctctgag gaaccatgag atggatagtg ggggacctga gtcatactag 420
ggtaacttct tatatggtga catcactcct accgtagagg ggggacggta gtctgtggga 480
aatctaccct agtgaagaaa ggtaagagaa tgtctgaaca ttacctgtag acgaaggtac 540
tctcagaaca actactctca catacggaaa ggtttgggtc cttggtcaaa ggactttact 600
gactctgcag acgatgaata tctgaaccaa cactactatc aaagatgttc gactagacct 660
ctcgtggtag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 700
<210> 6
<211> 1003
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 6
gcttgtccgc gagtgtcaac cgggttttac aaaggagaac ttccaacatc agtgtatggg 60
atgtttcaaa cacccccaga gacggagaca atagtgtggt cacgtacatt taggaagata 120
aaaataacaa caacagaagg tgtgaggcgc aaggtacatg ctcttacccc actctcagca 180
cgtagggagc ggagtgtgga agaccaacaa gcccgtcgcc tctaccaaat acagtgttta 240
ggtgtgtcgg agggcagaaa ccaacgaaag aaaggaaacg atcaacactt atatagtgtc 300
ctgtcgggcc caaatcctaa gagaccttag gtttaccaca ttagtactaa acagcctgtt 360
gtataccgtg agcccccact tcgatctgta aatggtaatc ccttgtaaaa cctcatctcc 420
aaaaacagta tacgcaggta cagctgatgt gatcctctct actagtcttc tctgaggaac 480
catgagatgt tatgataaca agtccaaacg tggacgtcgt cgctgtcacc tctcggaaca 540
ctagctgagg tggcttaaaa acattccgta actgagtggt caccgggggt gaaacatgct 600
gagggttcta ccttaacggg aaggtgaaac tctccaatgt ctttgaaagg actagttgag 660
ataacccaaa ccgaatccgg aggaagagga gaacttggaa aacgttgtac gacgtcatta 720
ataacgattc cgttcttccc gttcgtgtct ataaggatat tctttcattg cgaaggtaag 780
cccttttggg tctagatacg gactatactc aaaaacccac agaccttcca cttggagttg 840
ttttaggaga cggagtagta gagaaaactt gtggcacctt cccagtcggt tccctacaga 900
ctctccttag tagctcctaa gatcgtcgag ttacacgacg acattgttcc gactgacgta 960
gaggcattac tttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1003
<210> 7
<211> 774
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 7
gtgaggcatc tataccgcca cgccctatgt ctttctcacg tataggtgtg ctctcagctg 60
ccgttccggc gctgcttcac ccctttccgc ttatcgcgga tggtaaagtc aaagtttact 120
cagcggtcgc tgttgacctc aggttctcta tcaaaaattt gctggctaaa acggtcggag 180
cttctgctcc actctttcca gcaatccttc tgccagtcgc cttcaaactt gcaatctgtg 240
gattcgtcga acgtccgggt agtatagtta tctgcatcgt ggtcaccagt atcacagact 300
acaaaatctc aatcctccat tcccccgtca ggtctatcta aaattcaatc gctgtgtttg 360
cggggtaaat aataggacaa gtccgtataa tctacccaat cgcattcatt ccagtcagag 420
ggtaccaccg aatttcatca acaacattaa taattccata ggaactacat tcttaaatcc 480
ttggaactcc aaactcctac cttatcacgg ttctatccgt cgtcttaggg tcggtctcct 540
cgtagcatgg cctcgttctc ctcgccgtaa ttgcggtcga aagtacttca gttatttatg 600
gtgaggcttg tccgcgagtg tcaaccgggt tttacaaagg agaacttcca acatcagtgt 660
atgggatgtt tcaaacaccc ccagagacgg agacaatagt gtggtcacgt acatttagga 720
agataaaaat aacaacaaca gaagaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 774
<210> 8
<211> 732
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 8
gtcttccaca ctccgctccc tacgtgctga gagtggggta agagcatgta ccttgcgcct 60
cacaccttct gttgttgtta tttttatctt cctaaatgta cgtgaccaca ctattgtctc 120
cgtctctggg ggtgtttgaa acatcccata cactgatgtt ggaagttctc ctttgtaaaa 180
cccggttgac actcgcggac aagcctcact actttcgacc gcaattacgg cgaggagaac 240
gaggccatgc tacgaggaga ccgaccctaa gacgacggat agaaccgtga taaggtagga 300
gtttggagtt ccaaggattt aagaatgtag ttcctatgga attattaatg ttgttgatga 360
aattcggtgg taccctctga ctggaatgaa tgcgattggg tagattatac ggacttgtcc 420
tattatttac cccgcaaaca cagcgattga attttagata gacctgacgg gggaatggag 480
gattgagatt ttgtagtctc acagattgca agtttgaagg cgactggcag aaggattgct 540
ggaaagagtg gagcagaagc tccgaccgtt ttagccagca aatttttgat agagaacctg 600
aggtcaacag cgaccgctga gtaaactttg actttaccat ccgcgataag cggaaagggg 660
tgaagcagcg ccggaacggc agctgagagc acacctatac gtaaaaaaaa aaaaaaaaaa 720
aaaaaaaaaa aa 732
<210> 9
<211> 494
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 9
gggtgtttga aacatcccat acactgatgt tggaagttct cctttgtaaa acccggttga 60
cactcgcgga caagcctcac cataaataac tgaagtactt tcgaccgcaa ttacggcgag 120
gagaacgagg ccatgctacg aggagaccga ccctaagacg acggatagaa ccgtgataag 180
gtaggagttt ggagttccaa ggatttaaga atgtagttcc tatggaatta ttaatgttgt 240
tgatgaaatt cggtgaagga ttgctggaaa gagtggagca gaagctccga ccgttttagc 300
cagcaaattt ttgatagaga acctgaggtc aacagcgacc gctgagtaaa ctttgacttt 360
accatccgcg ataagcggaa aggggtgaag cagcgccgga acggcagctg agagcacacc 420
tatacgtgag aaagacatag ggcgtggcgg tatagatgcc tcacaaaaaa aaaaaaaaaa 480
aaaaaaaaaa aaaa 494
<210> 10
<211> 2081
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 10
gtgtatttat ccgctacgtg gtggatgaac atggatgcga acgacatttc gaaatatacg 60
caatgatatc caaccctacc gaaacagcaa taattgtaga aggtagcata tcatgccgag 120
agtttactac gttgtagcga gtttagttga aatagtttgt gatgtgtaaa ctaaaacata 180
ccaaatggta aaacttgtca cccccattta cattgcgaca gacacagtta tggagtggat 240
ggaagtgtgt tcgactgtca agacccttct ataatagtcg aaccagtacg gtaagtgggc 300
aacatgccca tataagtcga agcatttcaa atggttcatc cagtagacga cgatgtccta 360
gacagtcatg tctcttcccc atttgaagtc atgtagtggt tgtctacttt ttcattgaag 420
acgtccacct caacgctatg aacgttagtt gagacaatgt taaagcaaac gacaacgtca 480
ttgtgatcta catacacagt ggatggttag cgtaaacatg gtggaacgta ctttgactgc 540
gctgcaagaa atggttgggt cgatcgtaat gctagtcgtt acatcggaac aagccaaaac 600
aaatcattcg ctggatttag acctactgca cgacgacgtc gacacaagac attcttgaaa 660
ggaattcaat gcagaaactc ctatgcacgt cgaactagtc tcttgctcag cgctagtcca 720
tgaaaatgtc ctagctttga acgtttatca aatgcaagtt gtgggagtta gtcatgtgag 780
agttgtgcaa gaaagtgtta acgttctagc cgtgctcagt aacaattacc attcggcggt 840
aacaaacgta agttgtcact gcactcatga gcatgaagtt agaccagtag ttgggtcaga 900
aattagacgt ggtttagtct ggttaccgtg gaaagaatag ctgaactcaa agaagccgac 960
aaagataaac aaagaagaaa cggttaatac gattgaggag aaatattcaa tccaacggca 1020
actattaacg tttcaactag aatctacgtt tcatacgcgg attccacatc cgttcttgca 1080
attaaagaaa cgatgtagaa aacgctttgg ttggcgacaa cttgggcggc aaaataatta 1140
tggtaggtaa ttgaagtagc gttaaaacgc aaaaagaagg aagcacggat cactgcaaaa 1200
aggactactc aataatggtt tctaaagtca ttatgctggt gctccctatg gcggtggtca 1260
gtactgtaac taaagatgga ttacggcact tgtagagcac gtatcagacc cagctttgaa 1320
agaaggctga gttcggttcg ggtttcacgt aggcctagaa cgaggtatag aagtggttaa 1380
caaagatttg gttaccatgt aagaagcggt agacgccatg gcctagtagg aagaatgctt 1440
gttcacggag ccgacgaagt tagacgagtg gcagaagaaa gagcattatc ttggtactcg 1500
gactgaatgc gtactacggt cgtccaagtt gcaagaggta ttagagtcat tcgaatagct 1560
gtgggagtgg tatttatagc ataataagtg taaaaaacat tcccaacagc atatgtgtag 1620
ccaagaagcg ttgtgctcgc gactaaaagt caggtagcag caggcattaa cccagtgata 1680
gaacatcaaa gtcaaataag tatggtttag cattactgcg tatcttgcga ttgcgtgctg 1740
gtggtcaaca gtgcaaacct agtggcttcg cactcaaatg tagacaagca ttaaccaact 1800
acttctaacg tatgttcagg aagaatggct attctcgtca ggtgaatgcg taatcgaatg 1860
agtagtatgg tcgaacgtcc cgctatagtc tgacacgatt caggcaaagt tggagtgcaa 1920
agccatgatt tggtcgatgc ggcaaatgtt gcttaggact attctatggt cttgcgtaat 1980
tgtgaagatt tgccagttat ctaaggagac gtggtgattc gctctatagc tgtatctaat 2040
ctgccagatt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 2081
<210> 11
<211> 2001
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 11
gttggtgtat ttatccgcta cgtggtggat gaacatggat gcgaacgaca tttcgaaata 60
tacgcaatga tatccaaccc taccgaaaca gcaataattg tagaaggtag catatcatgc 120
cgagagttta ctacgttgta gcgagtttag ttgaaatagt ttgtgatgtg taaactaaaa 180
cataccaaat ggtaaaactt gtcaccccca tttacattgc gacagacaca gttatggagt 240
ggatggaagt gtgttcgact gtcaagaccc ttctataata gtcgaaccag tacggtaagt 300
gggcaacatg cccatataag tcgaagcatt tcaaatggtt catccagtag acgacgatgt 360
cctagacagt catgtctctt ccccatttga agtcatgtag tggttgtcta ctttttcatt 420
gaagacgtcc acctcaacgc tatgaacgtt agttgagaca atgttaaagc aaacgacaac 480
gtcattgtga tctacataca cagtggatgg ttagcgtaaa catggtggaa cgtactttga 540
ctgcgctgca agaaatggtt gggtcgatcg taatgctagt cgttacatcg gaacaagcca 600
aaacaaatca ttcgctggat ttagacctac tgcacgacga cgtcgacaca agacattctt 660
gaaagcgcta gtccatgaaa atgtcctagc tttgaacgtt tatcaaatgc aagttgtggg 720
agttagtcat gtgagagttg tgcaagaaag tgttaacgtt ctagccgtgc tcagtaacaa 780
ttaccattcg gcggtaacaa acgtaagttg tcactgcact catgagcatg aagttagacc 840
agtagttggg tcagaaatta gacgtggttt agtctggtta ccgtggaaag aatagctgaa 900
ctcaaagaag ccgacaaaga taaacaaaga agaaacggtt aatacgattg aggagaaata 960
ttcaatccaa cggcaactat taacgtttca actagaatct acgtttcata cgcggattcc 1020
acatccgttc ttgcaattaa agaaacgatg tagaaaacgc tttggttggc gacaacttgg 1080
gcggcaaaat aattatggta ggtaattgaa gtagcgttaa aacgcaaaaa gaaggaagca 1140
cggatcactg caaaaaggac tactcaataa tggtttctaa agtcattatg ctggtgctcc 1200
ctatggcggt ggtcagtact gtaactaaag atggattacg gcacttgtag agcacgtatc 1260
agacccagct ttgaaagaag gctgagttcg gttcgggttt cacgtaggcc tagaacgagg 1320
tatagaagtg gttaacaaag atttggttac catgtaagaa gcggtagacg ccatggccta 1380
gtaggaagaa tgcttgttca cggagccgac gaagttagac gagtggcaga agaaagagca 1440
ttatcttggt actcggactg aatgcgtact acggtcgtcc aagttgcaag aggtattaga 1500
gtcattcgaa tagctgtggg agtggtattt atagcataat aagtgtaaaa aacattccca 1560
acagcatatg tgtagccaag aagcgttgtg ctcgcgacta aaagtcaggt agcagcaggc 1620
attaacccag tgatagaaca tcaaagtcaa ataagtatgg tttagcatta ctgcgtatct 1680
tgcgattgcg tgctggtggt caacagtgca aacctagtgg cttcgcactc aaatgtagac 1740
aagcattaac caactacttc taacgtatgt tcaggaagaa tggctattct cgtcaggtga 1800
atgcgtaatc gaatgagtag tatggtcgaa cgtcccgcta tagtctgaca cgattcaggc 1860
aaagttggag tgcaaagcca tgatttggtc gatgcggcaa atgttgctta ggactattct 1920
atggtcttgc gtaattgtga agatttgcca gttatctaag gagacgtggt gaaaaaaaaa 1980
aaaaaaaaaa aaaaaaaaaa a 2001
<210> 12
<211> 716
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 12
gctacgtggt ggatgaacat ggatgcgaac gacatttcga aatatacgca atgatatcca 60
accctaccga aacagcaata attgtagaag gtagcatatc atgccgagtc atcgacatgc 120
ctttatcgac acacgacgtg attggagttt actacgttgt agcgagttta gttgaaatag 180
tttgtgatgt gtaaactaaa acataccaaa tggtaaaact tgtcaccccc atttacattg 240
cgacagacac agttatggag tggatggaag tgtgttcgac tgtcaagacc cttctataat 300
agtcgaacca gtacggtaag tgggcaacat gcccatataa gtcgaagcat ttcaaatggt 360
tcatccagta gacgacgatg tcctagacag tcatgtctct tccccatttg aagtcatgta 420
gtggttgtct actttttcat tgaagacgtc cacctcaacg ctatgaacgt tagttgagac 480
aatgttaaag caaacgacaa cgtcattgtg atctacatac acagtggatg gttagcgtaa 540
acatggtgga acgtactttg actgcgctgc aagaaatggt tgggtcgatc gtaatgctag 600
tcgttacatc ggaacaagcc aaaacaaatc attcgctgga tttagaccta ctgcacgacg 660
acgtcgacac aagacattct tgaaagaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 716
<210> 13
<211> 770
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 13
gtaaaacttg tcacccccat ttacattgcg acagacacag ttatggagtg gatggaagtg 60
tgttcgactg tcaagaccct tctataatag tcgaaccagt acggtaagtg ggcaacatgc 120
ccatataagt cgaagcattt caaatggttc atccagtaga cgacgatgtc ctagacagtc 180
atgtctgtca catctatcac gcctcctacg ttgtgccata acgaagaata atagtgataa 240
gagacatcga agctgtcgta gtcgttcgct aaattgctta caatttagtg ctctaagtga 300
acaatgtttc atcttgagaa gcaaacgaag tagaagttga cgacgcattc gaagacgtgg 360
acaatgtgac acgagtatcg aaacatgatc caacgaacat cgaagaagtt actactgaac 420
tacgggtcag cttccccatt tgaagtcatg tagtggttgt ctactttttc attgaagacg 480
tccacctcaa cgctatgaac gttagttgag acaatgttaa agcaaacgac aacgtcattg 540
tgatctacat acacagtgga tggttagcgt aaacatggtg gaacgtactt tgactgcgct 600
gcaagaaatg gttgggtcga tcgtaatgct agtcgttaca tcggaacaag ccaaaacaaa 660
tcattcgctg gatttagacc tactgcacga cgacgtcgac acaagacatt cttgaaaggt 720
aattgacgtg gacgtttcag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 770
<210> 14
<211> 553
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 14
gccgcatcga ccaaatcatg gctttgcact ccaactttgc ctgaatcgtg tcagactata 60
gcgggacgtt cgaccatact actcattcga ttacgcattc acctgacgag aatagccatt 120
cttcctgaac atacgttaga agtagttggt taatgcttgt ctacatttga gtgcgaagcc 180
actaggtttg cactgttgac caccagcacg caatcgcaag atacgcagta atgctaaacc 240
atacttattt gactttgatg ttctatcact gggttaatgc ctgctgctac ctgactttta 300
gtcgcgagca caacgcttct tggctacaca tatgctgttg ggaatgtttt ttacacttat 360
tatgctataa ataccactcc cacagctatt cgaatgactc taatacctct tgcaacttgg 420
acgaccgtag tacgcattca gtccgagtac caagataatg ctctttcttc tgccactcgt 480
ctaacttcgt cggctccgtg aacaagcatt cttcctacta ggcaaaaaaa aaaaaaaaaa 540
aaaaaaaaaa aaa 553
<210> 15
<211> 454
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 15
gttgaggtgg acgtcttcaa tgaaaaagta gacaaccact acatgacttc aaatggggaa 60
gctgacccgt agttcagtag taacttcttc gatgttcgtt ggatcatgtt tcgatactcg 120
tgtcacattg tccacgtctt cgaatgcgtc gtcaacttct acttcgtttg cttctcaaga 180
tgaaacattg ttcacttaga gcactaaatt gtaagcaatt tagcgaacga ctacgacagc 240
ttcgatgtct cttatcacta ttattcttcg ttatggcaca acgtaggagg cgtgatagat 300
gtgacagaca tgactgtcta ggacatcgtc gtctactgga tgaaccattt gaaatgcttc 360
gacttatatg ggcatgttgc ccacttaccg tactggttcg actattatag aagggtcttg 420
acagaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 454
<210> 16
<211> 2497
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 16
gtggagaagc aaatacttgg ataccgaatt tagaggccat aggttatgga aaaagtcagt 60
ggattagata gtaaaagtcg aaatctttat attcggttcg atgtactacg ttattcgcga 120
ctgttctgtc atgatagttt tttatatagt cctaataaaa ggagttttta aagtaaatga 180
catttcagta gtaaaagttt aagagctttt tgttctgcca gacgttctga tagttgagga 240
aaacgtgtgg tcagctaata acttgtggta tggagtaaac gaacatccaa cagtatgtac 300
aatcgtatga gaaaggacaa atctgaagac gatattagag ggagtccaac aagtttgtga 360
tgattcacgt aaggaaatcg aaatgtaaga ttattcgtca atggaggtat aagacaacac 420
accaagtaat tatacgcgac gagttttcat gttgacgatc cctgagacta tatcatacaa 480
aattgaccca aataataaac tcgttccaat agttgaagtg ttgattaaca cattgagaca 540
agttgtccgt actttaatca tcaaagtttt ggactgacct ataaatgaaa tattcgcgtt 600
gtcttcagtt taagaagtga tattattttc ggtttcaagc ctatgtggag agatacagga 660
aataggtaaa ctataactaa tataaatata cgcagacgaa gcctgttaac tttaccaaat 720
ccaaatagcg ggagacacta aacttacaag aaatgtacgg taagacaggg aaacagggtt 780
tgaagtttgg aggtacaaaa tcttaatcct tcacaactga atcaacattt acattcggtt 840
acgttcgggg tttgtagtag taattgttga ggtaatttta attgcactta cagacgtgga 900
tttggtgaaa cattatgtgg tagattcata tttccgaatc ttaatagacg attttatgat 960
ggtgatcgtg gtttcttttc aaggtttggt ggacgaaaat gaaaaaatca caatttaacg 1020
tttcatattc atcacaatcc gaaatcgaga tggagagaaa gtttgactaa actttgttac 1080
agtatttttg aaggcaatca acctggaact ttggatttca tcaagtaaac acccatattt 1140
agcgaaaatg caagctaact gcgaactaac aaggtaactc tttttcgatt tcaaaatatg 1200
gtcagtagca atatgttaag tgatccattt tggaggggtg gggatttgtt caatgaatga 1260
ggcaataaac caccgcaacc tctgtaattg acgagaaact tgtataaggt catcaaaaag 1320
aatagatgaa cataaagatt gaatacggct gggtgaggtt aattcagatt tcccaaatta 1380
tgtagatgaa aagatggtaa gtttattgat aggtaaaaaa tcaagagagg gtaataaaga 1440
agaaagaata atcaaaagat agagcatgca aacattacat ggtagtattg ttataggcgg 1500
tatattggta aatgacgatc cttgacttag ttttttacat cgaacggttg caaatcctag 1560
catacttgat attaatagta gatactgaaa tatatctgag tatatcaagg gaaatcgaga 1620
tgtaacaata agtcgaggaa attaaggtca atttagtgct tatcatagaa ataactactt 1680
aagcccttaa cgaactaact caaattaacg aggtagaggt tattctgaat tgtacgaacg 1740
tagtcgaagt ttgttaccaa gggtaaagcc aaaacaaaac gatttgacaa gagaatctat 1800
tccatgtagt agtgcgtttg tacgacgttc tattcgatgt aaatcattag gacgagggtt 1860
tgaagcaact cggaaagatg gtcggttaga atttaaaagt actgaacgga attaacgaag 1920
ttggctacta cctaatagtc tttgcttagg atttagtagt tcgcaattgg gtcaaagtgg 1980
tcgctttggt cgtcgacgtc aagactcaac aagtcattta ccgctgtacg aaccatctca 2040
tttaacaggt tctcaaccaa atagcggtag gagtagaaag cacttaccat cgtacgaact 2100
ttgacaacga aaggttcaaa ggtaaccaag gcgtagtagt gagttaggtc aatgtataaa 2160
aactcccttt cttattttga gtcgtcaatg tagtcgagaa agtatgcact tagtgccatt 2220
attattagac aagatagtcc gttctttagt cgaagttctt gttgtaataa caaaagtaga 2280
gcagattacg atccgaaatt tcatggacac agatatttga gatcaacatt tgattcgttg 2340
acgtatttat gttgattcgg ttagcgagag ttacaaagtt agtaatagaa agaaagagga 2400
aataataatc aaaagattaa gcatgcaaac attaagagga cacatatgta ttggtggcat 2460
ttgcgttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 2497
<210> 17
<211> 1837
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 17
gataccgaat ttagaggcca taggttatgg aaaaagtcag tggagtaaac gaacatccaa 60
cagtatgtac aatcgtatga gaaaggacaa atctgaagac gatattagag ggagtccaac 120
aagtttgtga tgattcacgt aaggaaatcg aaatgtaaga ttattcgtca atggaggtat 180
aagacaacac accaagtaat tatacgcgac gagttttcat gttgacgatc cctgagacta 240
tatcatacaa aattgaccca aataataaac tcgttccaat agttgaagtg ttgattaaca 300
cattgagaca agttgtccgt actttaatca tcaaagtttt ggactgacct ataaatgaaa 360
tattcgcgtt gtcttcagtt taagaagtga tattattttc ggtttcaagc ctatgtggag 420
agatacagga aataggtaaa ctataactaa tataaatata cgcagacgaa gcctgttaac 480
tttaccaaat ccaaatagcg ggagacacta aacttacaag aaatgtacgg taagacaggg 540
aaacagggtt tgaagtttgg aggtacaaaa tcttaatcct tcacaactga atcaacattt 600
acattcggtt acgttcgggg tttgtagtag taattgttga ggtaatttta attgcactta 660
cagacgtgga tttggtgaaa cattatgtgg tagattcata tttccgaatc ttaatagacg 720
attttatgat ggtgatcgtg gtttcttttc aaggtttggt ggacgaaaat gaaaaaatca 780
caatttaacg tttcatattc atcacaatcc gaaatcgaga tggagagaaa gtttgactaa 840
actttgttac agtatttttg aaggcaatca acctggaact ttggatttca tcaagtaaac 900
acccatattt agcgaaaatg caagctaact gcgaactaac aaggtaactc tttttcgatt 960
tcaaaatatg gtcagtagca atatgttaag tgatccattt tggaggggtg gggatttgtt 1020
caatgaatga ggcaataaac caccgcaacc tctgtaattg acgagaaact tgtataaggt 1080
catcaaaaag aatagatgaa cataaagatt gaatacggct gggtgaggtt aattcagatt 1140
tcccaaatta tgtagatgaa aagatggtaa gtttattgat aggtaaaaaa tcaagagagg 1200
gtaataaaga agaaagaata atcaaaagat agagcatgca aacattacat ggtagtattg 1260
ttataggcgg tatattggta aatgacgatc cttgacttag ttttttacat cgaacggttg 1320
caaatcctag catacttgat attaatagta gatactgaaa tatatctgag tatatcaagg 1380
gaaatcgaga tgtaacaata agtcgaggaa attaaggtca atttagtgct tatcatagaa 1440
ataactactt aagcccttaa cgaactaact caaattaacg aggtagaggt tattctgaat 1500
tgtacgaacg tagtcgaagt ttgttaccaa gggtaaagcc aaaacaaaac gatttgacaa 1560
gagaatctat tccatgtagt agtgcgtttg tacgacgttc tattcgatgt aaatcattag 1620
gacgagggtt tgaagcaact cggaaagatg gtcggttaga atttaaaagt actgaacgga 1680
attaacgaag ttggctacta cctaatagtc tttgcttagg atttagtagt tcgcaattgg 1740
gtcaaagtgg tcgctttggt cgtcgacgtc aagactcaac aagtcattta ccgctgtacg 1800
aaccatcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 1837
<210> 18
<211> 2048
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 18
gataccgaat ttagaggcca taggttatgg aaaaagtcag tggattagat agtaaaagtc 60
gaaatcttta tattcggttc gatgtactac gttattcgcg actgttctgt catgatagtt 120
ttttatatag tcctaataaa aggagttttt aaagtaaatg acatttcagt agtaaaagtt 180
taagagcttt ttgttctgcc agacgttctg atagttgagg aaaacgtgtg gtcagctaat 240
aacttgtggt atggagtaaa cgaacatcca acagtatgta caatcgtatg agaaaggaca 300
aatctgaaga cgatattaga gggagtccaa caagtttgtg atgattcacg taaggaaatc 360
gaaatgtaag attattcgtc aatggaggta taagacaaca caccaagtaa ttatacgcga 420
cgagttttca tgttgacgat ccctgagact atatcataca aaattgaccc aaataataaa 480
ctcgttccaa tagttgaagt gttgattaac acattgagac aagttgtccg tactttaatc 540
atcaaagttt tggactgacc tataaatgaa atattcgcgt tgtcttcagt ttaagaagtg 600
atattatttt cggtttcaag cctatgtgga gagatacagg aaataggtaa actataacta 660
atataaatat acgcagacga agcctgttaa ctttaccaaa tccaaatagc gggagacact 720
aaacttacaa gaaatgtacg gtaagacagg gaaacagggt ttgaagtttg gaggtacaaa 780
atcttaatcc ttcacaactg aatcaacatt tacattcggt tacgttcggg gtttgtagta 840
gtaattgttg aggtaatttt aattgcactt acagacgtgg atttggtgaa acattatgtg 900
gtagattcat atttccgaat cttaatagac gattttatga tggtgatcgt ggtttctttt 960
caaggtttgg tggacgaaaa tgaaaaaatc acaatttaac gtttcatatt catcacaatc 1020
cgaaatcgag atggagagaa agtttgacta aactttgtta cagtattttt gaaggcaatc 1080
aacctggaac tttggatttc atcaagtaaa cacccatatt tagcgaaaat gcaagctaac 1140
tgcgaactaa caaggtaact ctttttcgat ttcaaaatat ggtcagtagc aatatgttaa 1200
gtgatccatt ttggaggggt ggggatttgt tcaatgaatg aggcaataaa ccaccgcaac 1260
ctctgtaatt gacgagaaac ttgtataagg tcatcaaaaa gaatagatga acataaagat 1320
tgaatacggc tgggtgaggt taattcagat ttcccaaatt atgtagatga aaagatggta 1380
agtttattga taggtaaaaa atcaagagag ggtaataaag aagaaagaat aatcaaaaga 1440
tagagcatgc aaacattaca tggtagtatt gttataggcg gtatattggt aaatgacgat 1500
ccttgactta gttttttaca tcgaacggtt gcaaatccta gcatacttga tattaatagt 1560
agatactgaa atatatctga gtatatcaag ggaaatcgag atgtaacaat aagtcgagga 1620
aattaaggtc aatttagtgc ttatcataga aataactact taagccctta acgaactaac 1680
tcaaattaac gaggtagagg ttattctgaa ttgtacgaac gtagtcgaag tttgttacca 1740
agggtaaagc caaaacaaaa cgatttgaca agagaatcta ttccatgtag tagtgcgttt 1800
gtacgacgtt ctattcgatg taaatcatta ggacgagggt ttgaagcaac tcggaaagat 1860
ggtcggttag aatttaaaag tactgaacgg aattaacgaa gttggctact acctaatagt 1920
ctttgcttag gatttagtag ttcgcaattg ggtcaaagtg gtcgctttgg tcgtcgacgt 1980
caagactcaa caagtcattt accgctgtac gaaccatcaa aaaaaaaaaa aaaaaaaaaa 2040
aaaaaaaa 2048
<210> 19
<211> 1113
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 19
gataccgaat ttagaggcca taggttatgg aaaaagtcag tggtacgaat tacgaacacc 60
ttaacattag ggaaacttag atagttgtac aaagtaacgt ataacaagta tcgcgtatgg 120
attagatagt aaaagtcgaa atctttatat tcggttcgat gtactacgtt attcgcgact 180
gttctgtcat gatagttttt tatatagtcc taataaaagg agtttttaaa gtaaatgaca 240
tttcagtagt aaaagtttaa gagctttttg ttctgccaga cgttctgata gttgaggaaa 300
acgtgtggtc agctaataac ttgtggtatg gagtaaacga acatccaaca gtatgtacaa 360
tcgtatgaga aaggacaaat ctgaagacga tattagaggg agtccaacaa gtttgtgatg 420
attcacgtaa ggaaatcgaa atgtaagatt attcgtcaat ggaggtataa gacaacacac 480
caagtaatta tacgcgacga gttttcatgt tgacgatccc tgagactata tcatacaaaa 540
ttgacccaaa taataaactc gttccaatag ttgaagtgtt gattaacaca ttgagacaag 600
ttgtcctatt gttataggcg gtatattggt aaatgacgat ccttgactta gttttttaca 660
tcgaacggtt gcaaatccta gcatacttga tattaatagt agcatcgtac gaactttgac 720
aacgaaaggt tcaaaggtaa ccaaggcgta gtagtgagtt aggtcaatgt ataaaaactc 780
cctttcttat tttgagtcgt caatgtagtc gagaaagtaa gatgcactta gtgccattat 840
tattagacaa gatagtccgt tctttagtcg aagttcttgt tgtaataaca aaagtagagc 900
agattacgat ccgaaatttc atggacacag atatttgaga tcaacatttg attcgttgac 960
gtatttatgt tgattcggtt agcgagagtt acaaagttag taatagaaag aaagaggaaa 1020
taataatcaa aagattaagc atgcaaacat taagaggaca catatgtatt ggtggcattt 1080
gcgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1113
<210> 20
<211> 466
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 20
gtacgaatta cgaacacctt aacattaggg aaacttagat agttgtacaa agtaacgtat 60
aacaagtatc gcgtatggat tagatagtaa aagtcgaaat ctttatattc ggttcgatgt 120
actacgttat tcgcgactgt tctgtcatga tagtttttta tatagtccta ataaaaggag 180
tttttaaagt aaatgacatt tcagtagtaa aagtttaaga gctttttgtt ctgccagacg 240
ttctgatagt tgaggaaaac gtgtggtcag ctaataactt gtggtatgtt tggaggtaca 300
aaatcttaat ccttcacaac tgaatcaaca tttacattcg gttacgttcg gggtttgtag 360
tagtaattgt tgaggtaatt ttaattgcac ttacagacgt ggatttggtg aaacattatg 420
tggtagattc atatttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 466
<210> 21
<211> 2403
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 21
gtggagaagc aaatacttgg ataccgaatt tagaggccat aggttatgga aaaagtcagt 60
ggtacgaatt acgaacacct taacattagg gaaacttaga tagttgtaca aagtaacgta 120
taacaagtat cgcgtatgga gtaaacgaac atccaacagt atgtacaatc gtatgagaaa 180
ggacaaatct gaagacgata ttagagggag tccaacaagt ttgtgatgat tcacgtaagg 240
aaatcgaaat gtaagattat tcgtcaatgg aggtataaga caacacacca agtaattata 300
cgcgacgagt tttcatgttg acgatccctg agactatatc atacaaaatt gacccaaata 360
ataaactcgt tccaatagtt gaagtgttga ttaacacatt gagacaagtt gtccgtactt 420
taatcatcaa agttttggac tgacctataa atgaaatatt cgcgttgtct tcagtttaag 480
aagtgatatt attttcggtt tcaagcctat gtggagagat acaggaaata ggtaaactat 540
aactaatata aatatacgca gacgaagcct gttaacttta ccaaatccaa atagcgggag 600
acactaaact tacaagaaat gtacggtaag acagggaaac agggtttgaa gtttggaggt 660
acaaaatctt aatccttcac aactgaatca acatttacat tcggttacgt tcggggtttg 720
tagtagtaat tgttgaggta attttaattg cacttacaga cgtggatttg gtgaaacatt 780
atgtggtaga ttcatatttc cgaatcttaa tagacgattt tatgatggtg atcgtggttt 840
cttttcaagg tttggtggac gaaaatgaaa aaatcacaat ttaacgtttc atattcatca 900
caatccgaaa tcgagatgga gagaaagttt gactaaactt tgttacagta tttttgaagg 960
caatcaacct ggaactttgg atttcatcaa gtaaacaccc atatttagcg aaaatgcaag 1020
ctaactgcga actaacaagg taactctttt tcgatttcaa aatatggtca gtagcaatat 1080
gttaagtgat ccattttgga ggggtgggga tttgttcaat gaatgaggca ataaaccacc 1140
gcaacctctg taattgacga gaaacttgta taaggtcatc aaaaagaata gatgaacata 1200
aagattgaat acggctgggt gaggttaatt cagatttccc aaattatgta gatgaaaaga 1260
tggtaagttt attgataggt aaaaaatcaa gagagggtaa taaagaagaa agaataatca 1320
aaagatagag catgcaaaca ttacatggta gtattgttat aggcggtata ttggtaaatg 1380
acgatccttg acttagtttt ttacatcgaa cggttgcaaa tcctagcata cttgatatta 1440
atagtagata ctgaaatata tctgagtata tcaagggaaa tcgagatgta acaataagtc 1500
gaggaaatta aggtcaattt agtgcttatc atagaaataa ctacttaagc ccttaacgaa 1560
ctaactcaaa ttaacgaggt agaggttatt ctgaattgta cgaacgtagt cgaagtttgt 1620
taccaagggt aaagccaaaa caaaacgatt tgacaagaga atctattcca tgtagtagtg 1680
cgtttgtacg acgttctatt cgatgtaaat cattaggacg agggtttgaa gcaactcgga 1740
aagatggtcg gttagaattt aaaagtactg aacggaatta acgaagttgg ctactaccta 1800
atagtctttg cttaggattt agtagttcgc aattgggtca aagtggtcgc tttggtcgtc 1860
gacgtcaaga ctcaacaagt catttaccgc tgtacgaacc atctcattta acaggttctc 1920
aaccaaatag cggtaggagt agaaagcact taccatcgta cgaactttga caacgaaagg 1980
ttcaaaggta accaaggcgt agtagtgagt taggtcaatg tataaaaact ccctttctta 2040
ttttgagtcg tcaatgtagt cgagaaagtg tccaagcaaa acgtaacgaa acggttgagt 2100
aaggacttgc acactatgcc cttgcgggtt tacctgcttg acgtagtcct gccacttatt 2160
atccgtgatt gttacctaat ggacaaccta atcgttagct taaagaagat gcacttagtg 2220
ccattattat tagacaagat agtccgttct ttagtcgaag ttcttgttgt aataacaaaa 2280
gtagagcagt attttgacgt atagggagac agtcattagg tcattaaccc agttactaag 2340
gacaacgtaa ccatcgaagt tattgaactt cagaaaaaaa aaaaaaaaaa aaaaaaaaaa 2400
aaa 2403
<210> 22
<211> 809
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 22
gataccgaat ttagaggcca taggttatgg aaaaagtcag tggtacgaat tacgaacacc 60
ttaacattag ggaaacttag atagttgtac aaagtaacgt ataacaagta tcgcgtatga 120
tagtaaaagt cgaaatcttt atattcggtt cgatgtacta cgttattcgc gactgttctg 180
tcatgatagt tttttatata gtcctaataa aaggagtttt taaagtaaat gacatttcag 240
tagtaaaagt ttaagagctt tttgttctgc cagacgttct gatagttgag gaaaacgtgt 300
ggtcagctaa taacttgtgg agtaaacgaa catccaacag tatgtacaat cgtatgagaa 360
aggacaaatc tgaagacgat attagaggga gtccaacaag tttgtgatga ttcacgtaag 420
gaaatcgaaa tgtaagatta ttcgtcaatg gaggtataag acaacacacc aagtaattat 480
acgcgacgag ttttcatgtt gacgatccct gagactatat catacaaaat tgacccaaat 540
aataaactcg ttccaatagt tgaagtgttg attaacacat tgagacaagt tgtccgatta 600
cgatccgaaa tttcatggac acagatattt gagatcaaca tttgattcgt tgacgtattt 660
atgttgattc ggttagcgag agttacaaag ttagtaatag aaagaaagag gaaataataa 720
tcaaaagatt aagcatgcaa acattaagag gacacatatg tattggtggc atttgcgtta 780
aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 809
<210> 23
<211> 509
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 23
ggcctctaaa ttcggtatcc aagtatttgc ttctccacct gccaagcgca cataaattct 60
ttgcgagtgt tgtttggcca cttttggtag ctcctgtttc ttggcaattt tggctgacac 120
gttcagtttc ttttgctcca acttcgtaag cagttagtgt aggcgtgcgc taaggcattg 180
cgctactcgc ttccatcgtt ggttctacca cccatatgcc atggcgtcct gtaagtttgc 240
gcctaattac tcgaagcgct ttcatttcta cgaaacgttt tggaataatg tcaacttggg 300
cattgttgaa actacggctt ccttaatgct cttgacaacc ttgtttagtt gttgttcttc 360
cttcttccag catttaataa ccggcttttg ttttaactcc ttcgcttttt cgactttctc 420
ctttagcacc gcaacgttct ttttaagcta caacgctttc ttgaaatgct tctcgtcata 480
aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 509
<210> 24
<211> 826
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 24
gtattagggc gcattgcgct ttgccgaacg cgtaattaca gaacttgtgg tttcggtttt 60
gtcgatagcg actggaactg ccgaactttg tttaataatt acacgttaat ctgggacaaa 120
aggcaagctg aagatcgcag taacagttgg ttctgcgaaa gttgaccaac ctatgcgact 180
ttctggtttt gcctgttatg aacaacgttg gcaggtaaag aagcggctga ctgctggtcg 240
aagagccaaa tggtcaacat tagcatagct tgtttcgtaa tcgattggct caactgccgc 300
cgtgtccacg cgttaaacgc ggttagtaac atccactgaa ctttcttcgc caacagtaca 360
agctggcagt tgcatgtctt tagtacagga gattgcaacg ctacctacgc aagctttgac 420
tgcgatgcta caccgcacga tagctcgcgt acctacactt ttacgcgcta ctactccgcg 480
aacataagcc acttcatgtt gaacgaatgg agaacgttat ggttcacttc tttatgcgac 540
cgaagaaggc gcagtgtttg cttgacaatt tactgtcgtg tcttcggtaa cagatatgct 600
accaagcgac ctaaccactt taagcagctt caccgtctta cgagacgtta acctaacgca 660
aatgccacca atacatatgt gtcctcttaa tgtttgcatg cttaatcttt tgattattat 720
ttcctctttc tttctattac taactttgta actctcgcta accgaatcaa cataaatacg 780
tcaacgaatc aaatgtaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 826
<210> 25
<211> 619
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 25
gcgtaattac agaacttgtg gtttcggttt tgtcgatagc gactggaact gccgaacttt 60
gtttaataat tacacgttaa tctgggacaa aaggcaagct gaagatcgca gtaacagttg 120
gttctgcgaa agttgaccaa cctatgcgac tttctggttt tgcctgttat gaacaacgtt 180
ggcaggtaaa gaagcggctg actgctggtc gaagagccaa atggtcaaca ttagcatagc 240
ttgtttcctc tttttcgttg cggagttaag taggagaacg ttatggttca cttctttatg 300
cgaccgaaga aggcgcagtg tttgcttgac aatttactgt cgtgtcttcg gtaacagata 360
tgctaccaag cgacctaacc accttcaccg tcttacgaga cgttaaccta acgcaaatgc 420
caccaataca tatgtgtcct cttaatgttt gcatgcttaa tcttttgatt attatttcct 480
ctttctttct attactaact ttgtaactct cgctaaccga atcaacataa atacgtcaac 540
gaatcaaatg ttgatctcaa atatctgtgt ccatgaaatt tcggatcgta aaaaaaaaaa 600
aaaaaaaaaa aaaaaaaaa 619
<210> 26
<211> 191
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 26
gctgaccaca cgttttcctc aactatcaga acgtctggca gaacaaaaag ctcttaaact 60
tttactactg aaatgtcatt tactttaaaa actcctttta ttaggactat ataaaaaact 120
atcatgacag aacagtcgcg aataacgtag tacatcgaac caaaaaaaaa aaaaaaaaaa 180
aaaaaaaaaa a 191
<210> 27
<211> 2283
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 27
gttgaactta tacagaaata ctaaaagtcg aacaaccatt cgatttagga atacagaacg 60
ataacgcagc agaagtagtt gaccaccgtg taacttgaat ggtgatggtc ctggttctat 120
taatacaaat ccttttactt atgctccgtg atacagaaca actaaaagaa ctaaaagaga 180
agaacgacgt gcacgtgcta attatgcgaa ttaacatcgg gttagaaaaa gtaaactaaa 240
ggaaaatggg taaggcatat gccttactaa attgtgtaaa agaagttcta ataagaaccg 300
gaatgtatgt aattattcgc aagggttcca taaggcacat atacaaattt agaaacaacc 360
cgttacatta acaaaggtga acggtgtttc acagatatta gaccattagg taaccaatga 420
catttcacta tcgaaaaggg tatagtatta actactacaa ctaatccgac tcgtcgaggt 480
gatttataca ggactgcagg tagcaaacga cgaggtggac gagggtaagg tggccgacga 540
aagggaggac atgcacctag ttgaacacga ctaggaggac gatggccact acggagtgga 600
acacaaaggt aaagttgcaa taataaccag tacaacaaaa gcatacgtgg aaggtgacaa 660
gcaaacgatg tcttgaacaa caccgtcttc attgtttacc atttgctgtt ggatttgata 720
tttagagcgt atgttgaaga agttggaact ctggacacat tagagactta ttggatcgat 780
caagaggaat gcaatacgaa gtagtttcac tttcgtaggt taccctataa cacgcaaata 840
gatgtaatca acctcttatt aatcatacac tagacatcag atgttaatga cctaacgatt 900
atagtgctga acaacgtcta cgacaatata aacctttgca aagactggtc aaacatcaat 960
gttaaacacg tccagataaa agcaaaaagg taagacgagg attacggaat aattaatata 1020
gtgcttgttc caatcggccc ggcttcagtc attcccggtg gcgaagccat aacatttaaa 1080
aatagcctgt taacttcaag ctgtagtagc ctaaacaggt ttcctaatag tatgcaaaca 1140
acatagttca atagaagtta ttaataaaca tcaaattgtc tttgaacaac acaaacacgt 1200
aagctttcgg caactaaatt aactaaaaaa taactataat tacacagaac acgaagtcat 1260
ctgtttccta ttaaaaaata ggtacttgac aggttacaat ataacctgtt tctagcatgt 1320
ataacaaaat taagcgacga ccgagcgacg acaacaagca gcagccaggt gggcaaaagg 1380
ctaagactgc tttgatgtcc tgagccaact tgccgatacg cagcaacatt ttagaaacgt 1440
catcctgacc gccgccgcca ttgccataaa tgatagcttg gcggtagccg cccaaaacta 1500
tgaaaaaaat taaattaagg aaagacataa acaaggtagt taagccatgc acctagaaaa 1560
ttttgaacgg ctcagctgca acatattagc gctagaaatg acctaccata atgatataga 1620
agataattac cattactgcc accgcctcct ccgctgccgc ctcctccata gcagcttcta 1680
ttcaaacaaa ctccgccgcc gccaccgccg ccataaccac caccataacc accgccgtat 1740
acacaaacgc cgctccttct aagtcttagc tattaataac aaccgtggaa acaaaaaacg 1800
taatataggc tacagctgtg tcaacagcca aatccataac aacaaaatcc atggtgactg 1860
taacagacac tgttacaacc atattattaa ctagatagtg gttacagata atcatgcagc 1920
aacaacatat aaagaagacg gttaaagtta ttgacttatg ttagcatgtg caaattaaca 1980
taggctagtc ttaacctgac tcgctgtcgc gactggcatg caaagtttga cacgccgcgg 2040
ctctagtacg cgtcatcttt cagctgtaat aactacaaac acatcaaaaa aagtcggttt 2100
aaaacaactt gtgaaacgtc aacttggtaa ataaacctat tattaaagaa tctagatcaa 2160
tgtccaaaaa gattatttcc attgttacgt ctaaatacag attctgcgaa aacaagccat 2220
tagtatagta gaagaactaa ccatcgtatg ttcaaaaaaa aaaaaaaaaa aaaaaaaaaa 2280
aaa 2283
<210> 28
<211> 2089
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 28
gtgtaaccat cttacggatg taatctaacg taaacaccag agaaacaacc atcaaaacgg 60
cataatgggc aagcattatt aggaacatct aaatataaaa ccattgcctt aactcacata 120
acgctacact tggtaacacc accatatgca gtgcaagaac gttgggtaag agaacatcga 180
acgtatggtc tgtttacata agctcaaaaa taattttaca gggtaaaacg tcaatcatta 240
cttaacagca gtaatgctta caaatgtttc ggttagtatt taaaaccgta acgaacgcca 300
cgtgtaaaaa caagaggttt tattaatatt gggtatatta gatgtatccg tcgattaacc 360
caccataacc aaactaaatt aaagcaacga cttatgcgaa atcctccttg tttacaaact 420
aacagtaatg caagtcgtaa taaacgtctt aaatatttta taggtaaaag atttggacca 480
tatcctcagt actgtaatga taaacaccga cgaagtctac atcgttgcaa cggaaaattc 540
catgaaagtc gtatgtttta tggtaaactt ccgaatttag caaaaagggt tgtaaaaggt 600
atacgtcatc atggtaagaa atacagctgt attagtatat aaggttgtag aaaaccacat 660
aataatatgt ctttagcact agacatcaga tgttaatgac ctaacgatta tagtgctgaa 720
caacgtctac gacaatataa acctttgcaa agactggtca aacatcaatg ttaaacacgt 780
ccagataaaa gcaaaaaggt aagacgagga ttacggaata attaatatag tgcttgttcc 840
aatcggcccg gcttcagtca ttcccggtgg cgaagccata acatttaaaa atagcctgtt 900
aacttcaagc tgtagtagcc taaacaggtt tcctaatagt atgcaaacaa catagttcaa 960
tagaagttat taataaacat caaattgtct ttgaacaaca caaacacgta agctttcggc 1020
aactaaatta actaaaaaat aactataatt acacagaaca cgaagtcatc tgtttcctat 1080
taaaaaatag gtacttgaca ggttacaata taacctgttt ctagcatgta taacaaaatt 1140
aagcgacgac cgagcgacga caacaagcag cagccaggtg ggcaaaaggc taagactgct 1200
ttgatgtcct gagccaactt gccgatacgc agcaacattt tagaaacgtc atcctgaccg 1260
ccgccgccat tgccataaat gatagcttgg cggtagccgc ccaaaactat gaaaaaaatt 1320
aaattaagga aagacataaa caaggtagtt aagccatgca cctagaaaat tttgaacggc 1380
tcagctgcaa catattagcg ctagaaatga cctaccataa tgatatagaa gataattacc 1440
attactgcca ccgcctcctc cgctgccgcc tcctccatag cagcttctat tcaaacaaac 1500
tccgccgccg ccaccgccgc cataaccacc accataacca ccgccgtata cacaaacgcc 1560
gctccttcta agtcttagct attaataaca accgtggaaa caaaaaacgt aatataggct 1620
acagctgtgt caacagccaa atccataaca acaaaatcca tggtgactgt aacagacact 1680
gttacaacca tattattaac tagatagtgg ttacagataa tcatgcagca acaacatata 1740
aagaagacgg ttaaagttat tgacttatgt tagcatgtgc aaattaacat aggctagtct 1800
taacctgact cgctgtcgcg actggcatgc aaagtttgac acgccgcggc tctagtacgc 1860
gtcatctttc agctgtaata actacaaaca catcaaaaaa agtcggttta aaacaacttg 1920
tgaaacgtca acttggtaaa taaacctatt attaaagaat ctagatcaat gtccaaaaag 1980
attatttcca ttgttacgtc taaatacaga ttctgcgaaa acaagccatt agtatagtag 2040
aagaactaac catcgtatga aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 2089
<210> 29
<211> 700
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 29
gtgaaaggtg atacatattt acttgacttc ttaagcagag agcgtcaaaa caggttgaac 60
ttatacagaa atactaaaag tcgaacaacc attcgattta ggagtgcaga tacagaacaa 120
ctaaaagaac taaaagagaa gaacgacgtg cacgtgctaa ttatgcgaat taacatcggg 180
ttagaaaaag taaactaaag gaaaatgggt aaggcatatg ccttactaaa ttgtgtaaaa 240
gaagttctaa taagaaccgg aatgtatgta attattcgca agggttccat aaggcacata 300
tacaaattta gaaacaaccc gttacattaa caaaggtgaa cggtgtttca cagatattag 360
accattaggt aaccaatgac atttcactat cgaaaagggt atagtattaa ctactacaac 420
taatccgact cgtcgaggtg atttatacag gactgcaggt agcaaacgac gaggtggacg 480
agggtaaggt ggccgacgaa agggaggaca tgcacctagt tgaacacgac taggaggacg 540
atggccacta cggagtggaa cacaaaggta aagttgcaat aataaccagt acaacaaaag 600
catacgtgga aggtgacaag caaacgatgt cttgaacaac accgtcttca ttgtttacca 660
tttgctgttg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 700
<210> 30
<211> 622
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 30
gcaattagga tcaggtggtt aatctgatac gatacagaac aactaaaaga actaaaagag 60
aagaacgacg tgcacgtgct aattatgcga attaacatcg ggttagaaaa agtaaactaa 120
aggaaaatgg gtaaggcata tgccttacta aattgtgtaa aagaagttct aataagaacc 180
ggaatgtatg taattattcg caagggttcc ataaggcaca tatacaaatt tagaaacaac 240
ccgttacatt aacaaaggtg aacggtgttt cacagatatt agaccattag gtaaccaatg 300
acatttcact atcgaaaagg gtatagtatt aactactaca actaatccga ctcgtcgagg 360
tgatttatac aggactgcag gtagcaaacg acgaggtgga cgagggtaag gtggccgacg 420
aaagggagga catgcaccta gttgaacacg actaggagga cgatggccac tacggagtgg 480
aacacaaagg taaagttgca ataataacca gtacaacaaa agcatacgtg gaaggtgaca 540
agcaaacgat gtcttgaaca acaccgtctt cattgtttac catttgctgt tgaaaaaaaa 600
aaaaaaaaaa aaaaaaaaaa aa 622
<210> 31
<211> 656
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 31
gccaaggtga accaggacga agtcgatgtt tcagaacctc ctttaggcct tttagacggt 60
ttaaacgaag cactagacca agtaataaaa gcggacgttg cacaggtacg tgcagataca 120
gaacaactaa aagaactaaa agagaagaac gacgtgcacg tgctaattat gcgaattaac 180
atcgggttag aaaaagtaaa ctaaaggaaa atgggtaagg catatgcctt actaaattgt 240
gtaaaagaag ttctaataag aaccggaatg tatgtaatta ttcgcaaggg ttccataagg 300
cacatataca aatttagaaa caacccgtta cattaacaaa ggtgaacggt gtttcacaga 360
tattagacca ttaggtaacc aatgacattt cactatcgaa aagggtatag tattaactac 420
tacaactaat ccgactcgtc gaggtgattt atacaggact gcaggtagca aacgacgagg 480
tggacgaggg taaggtggcc gacgaaaggg aggacatgca cctagttgaa cacgactagg 540
aggacgatgg ccactacgga gtggaacaca aaggtaaagt tgcaataata accagtacaa 600
caaaagcata cgtggaaggt gacaagaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 656
<210> 32
<211> 647
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 32
gacatcagat gttaatgacc taacgattat agtgctgaac aacgtctacg acaatataaa 60
cctttgcaaa gactggtcaa acatcaatgt taaacacgtc cagataaaag caaaaaggta 120
agacgaggat tacggaataa ttaatatagt gcttgttcca atcggcccgg cttcagtcat 180
tcccggtggc gaagccatgt caccaataaa aactatcggc ggcaatggaa gtggtttttc 240
ggaaactgtt acgggtgcaa gcggccccag tgcagtttgt gccttgccaa tcggcccagc 300
tttcaaacgc aaagttggac gacttattgg cccattctga caacgtcctg ttaaactgcc 360
cggacgttca aacggcggta tcggacgact aacgcgttac ggcggacaac tcgcccccag 420
tcaacaactt ggacacggta aatttgaacg ctaagtcaac tgtagcagtt aaacattgag 480
tattaaaata gatttaagct agcgttaaga acattaaaaa ctaaccagcc aaaccaagga 540
ttacggctgt ggtgtaatcg attgcgaaat agcatgacaa aaaacttaca gtttagaagg 600
tggcggtatt acttaagaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 647
<210> 33
<211> 2135
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 33
gcagatacag aacaactaaa agaactaaaa gagaagaacg acgtgcacgt gctaattatg 60
cgaattaaca tcgggttaga aaaagtaaac taaaggaaaa tgggtaaggc atatgcctta 120
ctaaattgtg taaaagaagt tctaataaga accggaatgt atgtaattat tcgcaagggt 180
tccataaggc acatatacaa atttagaaac aacccgttac attaacaaag gtgaacggtg 240
tttcacagat attagaccat taggtaacca atgacatttc actatcgaaa agggtatagt 300
attaactact acaactaatc cgactcgtcg aggtgattta tacaggactg caggtagcaa 360
acgacgaggt ggacgagggt aaggtggccg acgaaaggga ggacatgcac ctagttgaac 420
acgactagga ggacgatggc cactacggag tggaacacaa aggtaaagtt gcaataataa 480
ccagtacaac aaaagcatac gtggaaggtg acaagcaaac gatgtcttga acaacaccgt 540
cttcattgtt taccatttgc tgttggattt gatatttaga gcgtatgttg aagaagttgg 600
aactctggac acattagaga cttattggat cgatcaagag gaatgcaata cgaagtagtt 660
tcactttcgt aggttaccct ataacacgca aatagatgta atcaacctct tattaatcat 720
acactagaca tcagatgtta atgacctaac gattatagtg ctgaacaacg tctacgacaa 780
tataaacctt tgcaaagact ggtcaaacat caatgttaaa cacgtccaga taaaagcaaa 840
aaggtaagac gaggattacg gaataattaa tatagtgctt gttccaatcg gcccggcttc 900
agtcattccc ggtggcgaag ccataacatt taaaaatagc ctgttaactt caagctgtag 960
tagcctaaac aggtttccta atagtatgca aacaacatag ttcaatagaa gttattaata 1020
aacatcaaat tgtctttgaa caacacaaac acgtaagctt tcggcaacta aattaactaa 1080
aaaataacta taattacaca gaacacgaag tcatctgttt cctattaaaa aataggtact 1140
tgacaggtta caatataacc tgtttctagc atgtataaca aaattaagcg acgaccgagc 1200
gacgacaaca agcagcagcc aggtgggcaa aaggctaaga ctgctttgat gtcctgagcc 1260
aacttgccga tacgcagcaa cattttagaa acgtcatcct gaccgccgcc gccattgcca 1320
taaatgatag cttggcggta gccgcccaaa actatgaaaa aaattaaatt aaggaaagac 1380
ataaacaagg tagttaagcc atgcacctag aaaattttga acggctcagc tgcaacatat 1440
tagcgctaga aatgacctac cataatgata tagaagataa ttaccattac tgccaccgcc 1500
tcctccgctg ccgcctcctc catagcagct tctattcaaa caaactccgc cgccgccacc 1560
gccgccataa ccaccaccat aaccaccgcc gtatacacaa acgccgctcc ttctaagtct 1620
tagctattaa taacaaccgt ggaaacaaaa aacgtaatat aggctacagc tgtgtcaaca 1680
gccaaatcca taacaacaaa atccatggtg actgtaacag acactgttac aaccatatta 1740
ttaactagat agtggttaca gataatcatg cagcaacaac atataaagaa gacggttaaa 1800
gttattgact tatgttagca tgtgcaaatt aacataggct agtcttaacc tgactcgctg 1860
tcgcgactgg catgcaaagt ttgacacgcc gcggctctag tacgcgtcat ctttcagctg 1920
taataactac aaacacatca aaaaaagtcg gtttaaaaca acttgtgaaa cgtcaacttg 1980
gtaaataaac ctattattaa agaatctaga tcaatgtcca aaaagattat ttccattgtt 2040
acgtctaaat acagattctg cgaaaacaag ccattagtat agtagaagaa ctaaccatcg 2100
tatgtaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 2135
<210> 34
<211> 600
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 34
gtgaaaggtg atacatattt acttgacttc ttaagcagag agcgtcaaaa caggttgaac 60
ttatacagaa atactaaaag tcgaacaacc attcgattta ggagtgcaga tacagaacaa 120
ctaaaagaac taaaagagaa gaacgacgtg cacgtgctaa ttatgcgaat taacatcggg 180
ttagaaaaag taaactaaag gaaaatgggt aaggcatatg ccttactaaa ttgtgtaaaa 240
gaagttctaa taagaaccgg aatgtatgta attattcgca agggttccat aaggcacata 300
tacaaattta gaaacaaccc gttacattaa caaaggtgaa cggtgtttca cagatattag 360
accattaggt aaccaatgac atttcactat cgaaaagggt ataggaggac atgcacctag 420
ttgaacacga ctaggaggac gatggccact acggagtgga acacaaaggt aaagttgcaa 480
taataaccag tacaacaaaa gcatacgtgg aaggtgacaa gcaaacgatg tcttgaacaa 540
caccgtcttc attgtttacc atttgctgtt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 600
<210> 35
<211> 1597
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 35
gtgtagcata gcaactgttc tgaatgtgat attcggtcag gccacgttga cacttaccaa 60
agcaagacag aaggaagttg acgggacaat agggaagatt ggcaaaggga tttaaacata 120
gtccagttcg cgtggtgaat gacagattgc tactgttacc attggcgata ctacgttggc 180
gactttactt gcctcggtag cgacagaaca agtgtcgtct acgcaacgaa caaccagcgt 240
gttagctgca atgtcccctg tagaagaccc tcttctttct cttctgaatg atgtagctgt 300
ggatagagcg tctcccacgt tagggtctag caaccctccg gtggtgtgtg gtttcggttc 360
gcttggttgg gtgcccaatt tccagtaccg aagaggtaat tgcaacttca attgcttagt 420
tgacgtgacc tttcgggtgt catggactac cgacggtatc tcatacgtga cctcgttgtt 480
gacctcgttc ttcatctgca cagactacaa cgttaggact acggaaccag tgtgaagttg 540
acggacgcgc tagaagtctg acactgacca tgcttgtggc aatcgttgtt catgtagcca 600
ctttgactcg acgttcacga acatacgatg gttagttctt ctactatact aatggcttgt 660
tttcgcagaa tctgtattta gacgtaacaa tggaaataat ctttttggac attgatctag 720
attctttaat aataggttta tttaccaagt tgacgtttca caagttgttt taaaccgact 780
ttttttgatg tgtttgtagt tattacagct gaaagatgac gcgtactaga gccgcggcgt 840
gtcaaacttt gcatgccagt cgcgacagcg agtcaggtta agactagcct atgttaattt 900
gcacatgcta acataagtca ataactttaa ccgtcttctt tatatgttgt tgctgcatga 960
ttatctgtaa ccactatcta gttaataata tggttgtaac agtgtctgtt acagtcacca 1020
tggattttgt tgttatggat ttggctgttg acacagctgt agcctatatt acgttttttg 1080
tttccacggt tgttattaat agctaagact tagaaggagc ggcgtttgtg tatacggcgg 1140
tggttatggt ggtggttatg gcggcggtgg cggcggcgga gtttgtttga atagaagctg 1200
ctatggagga ggcggcagcg gaggaggcgg tggcagtaat ggtaattatc ttctatatca 1260
ttatggtagg tcatttctag cgctaatatg ttgcagctga gccgttcaaa attttctagg 1320
tgcatggctt aactaccttg tttatgtctt tccttaattt aatttttttc atagttttgg 1380
gcggctaccg ccaagctatc atttatggca atggcggcgg cggtcaggat gacgtttcta 1440
aaatgttgct gcgtatcggc aagttggctc aggacatcaa agcagtctta gccttttgcc 1500
cacctggctg ctgcttgttg tcgtcgctcg gtcgtcgctt aattttgtta tacatgctag 1560
aaacaggaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 1597
<210> 36
<211> 980
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 36
gatcgtggcc cagtcagtgg attacgttga ccatgagtct ggctgttctt ggttcaccat 60
tagctgtggt gacaataacg ggcattgtgg caacgatacg tcgtactgca agtcccactg 120
taactaagac aattcggatt cgaccgatac ttggtctggt tcgttaactt cgcgtacctt 180
ctgctttacc agcaggtcgt caacgacgag ccaccgtaac gagtgtggtt tcggttcgct 240
tggttgggtg cccaatttcc agtaccgaag aggtaattgc aacttcaatt gcttagttga 300
cgtgaccttt cgggtgtcat ggactaccga cggtatctca tacgtgacct cgttgttgac 360
ctcgttcttc atctgcacag actacaacgt taggactacg gaaccagtgt gaagttgacg 420
gacgcgctag tttacagatg cggtttattg gattggttac aacggcaaag gcggagacca 480
ctccaactgt cggaagagta cctcttcaaa ttgccattcc aattgctcgt catggacttt 540
ccactcttag acgacccgat gaagctagaa gtctgacact gaccatgctt gtggcaatcg 600
ttgttcatgt agccactttg actcgacgtt cacgaacata cgatggttag ttcttctact 660
atactaatgg cttgttttcg cagaatctgt atttagacgt aacaatggaa ataatctttt 720
tggacattga tctagattct ttaataatag gtttatttac caagttgacg tttcacaagt 780
tgttttaaac cgactttttt tgatgtgttt gtagttatta cagctgaaag atgacgcgta 840
ctagagccgc ggcgtgtcaa actttgcatg ccagtcgcga cagcgagtca ggttaagact 900
agcctatgtt aatttgcaca tgctaacata agtcaataac tttaaccgtc aaaaaaaaaa 960
aaaaaaaaaa aaaaaaaaaa 980
<210> 37
<211> 1920
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 37
gtagaccttt ccttgccgcg tggaacaaac cgccatgagt gttttacgtt tacggtcggc 60
gaccggagtc acagcgcgac caacggggcc aggcaaaggc ccataggctt ttccatcggc 120
acgcgaccga ttccatcaag tgttaggtgc aatccccatt cgggacggac acgcgagtaa 180
aggtctaaca tgtttcaact ttccagttag tcgccgtcct atattggcaa gaccggatgg 240
ccgtcaacca gttccattct gactatttgc cacattgatt aaagaagtag gagcgttagt 300
cggcgcgtgc gcgggactat ttagcgaagg tcgccgatcg tttgcccgta aaactaactg 360
gcaaaagcct aagtgctgtt tcgggtgcaa tggtataact tcccacattt agccgaatag 420
cgccaacagc gttattattt ggaaccaagc agtgggcgat gtcagcgaca attccacttt 480
ggtagaggtc gttcttttgt agaaaacaat ctaacataac tatgacactt tcggtaaatt 540
caccaccttt accagggtcg taagtggtca agccacgccg accacttcat aagcattggt 600
ggaaatcgca tcgacacaat aaaagtacac caaccagcag aaaacaggta catatacagt 660
ttaacgacct ggatctaaga tgactacagt agcatagcca tagaacatgg cactgaaata 720
tcgatgggcg taaaagtgaa caacgcagac gatggattac gacgccaagc cactataaat 780
gctaattgag tcgaagaagg tactcctttt tggaacacag atattgcaga agcgggaatg 840
aggttgatat tacatcaagt atcaacagac gacctcagaa gggtggtctt ttaaaatgac 900
aacgtacatt aagatgcaga caaacactac tatgctggat gtgaaaatgt catatgtgcg 960
gcaaaaatag acgacattta agaacctagc attataggat ggagtgttgt attaattcac 1020
tctagagtaa tggatcacgg tgccagaaac taaggtggtg taggactaga tgcaagtaac 1080
aacggtcgta ctaaaatcag ctacgcgatc gccgacttag aaggctgaga tggagaaact 1140
tgtctactgg cagacctcac tatcttttag gaaggtcacg aagcggctgg agtgatggct 1200
agtctcagcc actgtcaacg ggaagcgcga cgtttatggt caatataaac tagcagttta 1260
atccgtatgg cgatcttagc ggatgttaca ggatggagaa gatgacaaag tagaagctag 1320
acaactatat caaatcgttg tgtggtctta aaccgacaca gtagcattca tcgttggatg 1380
tggaaggtca cagcctcgtt ggaggagata ctacggtccc gcttttcgtg ggtgacaaag 1440
gtcgcaaagg tttccttagg gaggtcgttt cccggatctt tatctacatc tcctgggtga 1500
aggggatgat ctttctctac atagattgca gagagccagg tcaaatacat tgagaaatct 1560
gtatatgtac tttggtaacg ctctaaggta ggtacacgtt agtgatataa aaagaaggcg 1620
acgacgaact taaattgtta gagcagttta tgggtggtag gttacatcta tttacttcaa 1680
aacgcggtgc cctagcccac aagcattgct ttgtaaaatt gttgaaggta acttgtaaaa 1740
gccgaacatg aacgatggat agtagaccgg gaagaccaac gttttttcac tactccgaaa 1800
gaacacactg aagggaacgg tgtaggttcg gtgagtccgg gactaggtgt ccatgtcgga 1860
gacctcagtg gtgacgtcct cgtagtatag aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1920
<210> 38
<211> 2014
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 38
gacttgtagg cccatgaatt acccgcttag gcaatgggta gacctttcct tgccgcgtgg 60
aacaaaccgc catgagtgtt ttacgtttac ggtcggcgac cggagtcaca gcgcgaccaa 120
cggggccagg caaaggccca taggcttttc catcggcacg cgaccgattc catcaagtgt 180
taggtgcaat ccccattcgg gacggacacg cgagagcgtt agtcggcgcg tgcgcgggac 240
tatttagcga aggtcgccgt atcgcgggtg gcggcgtttc cgccataaca acaagcgttt 300
aaggtcagag tccgcgacga atgaaacgcc gtgcaagcgg ctttggtacg gccagtttag 360
ccaaagcctg atccgttcgc cttgggttat catgtaccag tcaagcggtc atcgcgggcg 420
gcgttatcat ggatcgtttg cccgtaaaac taactggcaa aagcctaagt gctgtttcgg 480
gtgcaatggt ataacttccc acatttagcc gaatagcgcc aacagcgtta ttatttggaa 540
ccaagcagtg ggcgatgtca gcgacaattc cactttggta gaggtcgttc ttttgtagaa 600
aacaatctaa cataactatg acactttcgg taaattcacc acctttacca gggtcgtaag 660
tggtcaagcc acgccgacca cttcataagc attggtggaa atcgcatcga cacaataaaa 720
gtacaccaac cagcagaaaa caggtacata tacagtttaa cgacctggat ctaagatgac 780
tacagtagca tagccataga acatggcact gaaatatcga tgggcgtaaa agtgaacaac 840
gcagacgatg gattacgacg ccaagccact ataaatgcta attgagtcga agaaggtact 900
cctttttgga acacagatat tgcagaagcg ggaatgaggt tgatattaca tcaagtatca 960
acagacgacc tcagaagggt ggtcttttaa aatgacaacg tacattaaga tgcagacaaa 1020
cactactatg ctggatgtga aaatgtcata tgtgcggcaa aaatagacga catttaagaa 1080
cctagcatta taggatggag tgttgtatta attcactcta gagtaatgga tcacggtgcc 1140
agaaactaag gtggtgtagg actagatgca agtaacaacg gtcgtactaa aatcagctac 1200
gcgatcgccg acttagaagg ctgagatgga gaaacttgtc tactggcaga cctcactatc 1260
ttttaggaag gtcacgaagc ggctggagtg atggctagtc tcagccactg tcaacgggaa 1320
gcgcgacgtt tatggtcaat ataaactagc agtttaatcc gtatggcgat cttagcggat 1380
gttacaggat ggagaagatg acaaagtaga agctagacaa ctatatcaaa tcgttgtgtg 1440
gtcttaaacc gacacagtag cattcatcgt tggatgtgga aggtcacagc ctcgttggag 1500
gagatactac ggtcccgctt ttcgtgggtg acaaaggtcg caaaggtttc cttagggagg 1560
tcgtttcccg gatctttatc tacatctcct gggtgaaggg gatgatcttt ctctacatag 1620
attgcagaga gccaggtcaa atacattgag aaatctgtat atgtactttg gtaacgctct 1680
aaggtaggta cacgttagtg atataaaaag aaggcgacga cgaacttaaa ttgttagagc 1740
agtttatggg tggtaggtta catctattta cttcaaaacg cggtgcccta gcccacaagc 1800
attgctttgt aaaattgttg aaggtaactt gtaaaagccg aacatgaacg atggatagta 1860
gaccgggaag accaacgttt tttcactact ccgaaagaac acactgaagg gaacggtgta 1920
ggttcggtga gtccgggact aggtgtccat gtcggagacc tcagtggtga cgtcctcgta 1980
gtataaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 2014
<210> 39
<211> 556
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 39
gtcacctaaa cgtgcgaagt gtgcgaaatt accaccgtaa attcgtccta ctgaaagtgc 60
ttacgcatct tgagagagat tgcagagagc caggtcaaat acattgagaa atctgtatat 120
gtactttggt aacgctctaa ggtaggtaca cgttagtgat ataaaaagaa ggcgacgacg 180
gtagcagagg tctagaaacc gcatgaacga ccaacttatt tgaagagcta gtgcggtgga 240
attgggtcgg aagaacttaa attgttagag cagtttatgg gtggtaggtt acatctattt 300
acttcaaaac gcggtgccct agcccacaag cattgctttg taaaattgtt gaaggtaact 360
tgtaaaagcc gaacatgaac gatggatagt agaccgggaa gaccaacgtt ttttcactac 420
tccgaaagaa cacactgaag ggaacggtgt aggttcggtg agtccgggac taggtgtcca 480
tgtcggagac ctcagtggtg acgtcctcgt agtataggtc cacgctaaaa aaaaaaaaaa 540
aaaaaaaaaa aaaaaa 556
<210> 40
<211> 2503
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 40
gtccacgctc taagtcgctt gcccaattgt ggctaccgca ttgctcagaa cttcgggtac 60
tggccaacct tcaagaagcc tagtcttggt gcgtcacccc agtcacgtag catacccgtc 120
atcatctatg gtcgtaggtc caacaatcgt ggcgccattg ggtaccactt catcagagct 180
gctcgcatga ccagctatat ctggaacatc gctggtgggt cttatggtcg cttttgtggg 240
aaccatcata gtcgcaagtc tggccttcgg tatggaactc gtcgtcccga ctacaaccat 300
agctagtctc ggtctcggct ttgttgcaat gcccttcgtt actacttcaa cggtcgtggt 360
gccggtcaaa ccgctcgcta aagcaagcga agaaacagct aaacttagtt gtgtcgaaac 420
atcctaagtg gtcgggttgc tcgtggagca tgcagctagc ccagaacctt tagcttgtgt 480
ggtcttcgtc tcggtagtca gaaccaggtc ggtctgaatg gttggactcg ccacatcaac 540
taggtcagct attgaagtgc caactaaagg tcgtattgaa gcaatcggtc ctatggcaag 600
tcaagtgaca gtcgtaggta tggcacttgc cgcgcctcca gaactcggtc aagctacctc 660
ataactcgga agtcgactgc tctaaagcga agttgtcaaa cgaacagcta tgccttcgag 720
taaagcaagg tgcgcaatag taaccttggt aacttcggaa ctgcgtcaag ccgctaactc 780
catcggtatg gaagtcgcta aagtcggtca aacggaagcg gctatcgtcg caactagtcg 840
aatagttgtc gaagaggcca gagcaaccat ggttgccatt gtcttcgtgg tctatgcaag 900
acgtccttgc gtcatggcct aagcatcttc ttcactggtt gctatagcgg aagtcgttac 960
cgaactggtc gccagtcgaa tcgtttgccc catggtagtc atcaccacca tcgcggaaac 1020
caacggtccg aactcacggt aggtagtcca cgtatgtagc ccacctttcg aaggaatcgt 1080
ggtcgccggt ctcctagaaa cggtatatgt cttgcgtcac gcttatggac cggtcatcct 1140
ggccagtagc cgacttgtgg tcgctatagc tttcgctagt ccctgcctta acgtgcagca 1200
tggtatggct attgtcgtcc cggctacaac cactatcgtg gtcttgaaac tggtcgtcgc 1260
tacaaccatc ctagcattgg caccagcggt cgttgaagcc gaaggtagtc tctaactggt 1320
tttcgaagct agtcaaacag tagcgccata tggcctagcc tgaaccttag aaaaaggagt 1380
cgaaggtcct aaacccgctg gtcgcgaacg aacaaaaacg gtcgttaaag gccgtccgga 1440
agcggaaggt cgtcgcccca ggtgaacaag tcctaaagaa acaaaaagtc tctgtagtct 1500
atttaaaacc caacgcaaac gcgaacgcag aatcgtctga acccacgtcc atcattacgg 1560
attatataag gtttctgttt cgttaactag gtagttattg atgtcatccg cactacaagc 1620
taacaggagg taacagatag agcatgagtg gtagtaggga tgaaacagga agtactaatt 1680
acatacaggg actcctggtt gggtgacccc gggacacgta cgtgtcctaa taaacaggag 1740
gcgggtggtt tcctatctac tacggacagg gattttcccc gagtagcgaa ggatatgaaa 1800
cttctagtta tagacatata agacgtagtc caggaagtcg gctgagtcca tgaggtcagt 1860
tttggaggag aagtagttgt cacgatcctt agttaagata acaaagtccg agtagttatc 1920
acgacttgct gactgcgtcc actatgtttc cggggtgggc atggggactt gcacacggat 1980
aactccatcc ggattattaa gacgaggtgg ggtgtgctgg gctcccagga acttcatcgg 2040
agtgacgtag aaccttcagt ttgagtccac gtaggacacc agcgctattg gtgccgacga 2100
cgagtacaaa catccggaaa cttagcatat taggtaagag tttctgtatg ctcggacgtc 2160
gtcgttagag cagacccaga aggtgtccat ggacacacat catacaagac aacttggtca 2220
acttttacgg ggctggggcc aattatcccg ggagtcctca cgatcagaaa ccgactggtt 2280
tgtcacactc tggttagagg aggggtcacc acgatgggtg agggggtggt gggtgtttat 2340
acaagagtct gggactccaa agacgatatt acgacgagac gacttatcca cgtactttgt 2400
ttcccaaacc cacgcaactc cacctttagt ccacacaaac tagtacgaga cacccggatt 2460
caaggtcgtg accaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 2503
<210> 41
<211> 2059
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 41
ggaccgaagc atactgcaag acttgtaggc ccatgaatta cccgcttagg caatgggtag 60
acctttcctt gccgcgtgga acaaaccgcc atgagtgttt tacgtttacg gtcggcgacc 120
ggagtcacag cgcgaccaac ggggccaggc aaaggcccat aggcttttcc atcggcacgc 180
gaccgattcc atcaagtgtt aggtgcaatc cccattcggg acggacacgc gagagcgtta 240
gtcggcgcgt gcgcgggact atttagcgaa ggtcgccgat cgtttgcccg taaaactaac 300
tggcaaaagc ctaagtgctg tttcgggtgc aatggtataa cttcccacat ttagccgaat 360
agcgccaaca gcgttattat ttggaaccaa gcagtgggcg atgtcagcga caattccact 420
ttggtagagg tcgttctttt gtagaaaaca atctaacata actatgacac tttcggtaaa 480
ttcaccacct ttaccagggt cgtaagtggt caagccacgc cgaccacttc ataagcattg 540
gtggaaatcg catcgacaca ataaaagtac accaaccagc agaaaacagg tacatataca 600
gtttaacgac ctggatctaa gatgactaca gtagcatagc catagaacat ggcactgaaa 660
tatcgatggg cgtaaaagtg aacaacgcag acgatggatt acgacgccaa gccactataa 720
atgctaattg agtcgaagaa ggtactcctt tttggaacac agatattgca gaagcgggaa 780
tgaggttgat attacatcaa gtatcaacag acgacctcag aagggtggtc ttttaaaatg 840
acaacgtaca ttaagatgca gacaaacact actatgctgg agtgttgtat taattcactc 900
tagagtaatg gatcacggtg ccagaaacta aggtggtgta ggactagatg caagtaacaa 960
cggtcgtact aaaatcagct acgcgatcgc cgacttagaa ggctgagatg gagaaacttg 1020
tctactggca gacctcacta tcttttagga aggtcacgaa gcggctggag tgatggctag 1080
tctcagccac tgtcaacggg aagcgcgacg tttatggtca atataaacta gcagtttaat 1140
ccgtatggcg atcttagcgg atgttacagg atggagaaga tgacaaagta gaagctagac 1200
aactatatca aatcgttgtg tggtcttaaa ccgacacagt agcattcatc gttggatgtg 1260
gaaggtcaca gcctcgttgg aggagatact acggtcccgc ttttcgtggg tgacaaaggt 1320
cgcaaaggtt tccttaggga ggtcgtttcc cggatcttta tctacatctc ctgggtgaag 1380
gggatgatct ttctctacat gtcctgggtg gaggggagtt tccttgtatg ggtggaaccc 1440
aacccgccgg tgagggtgag ttacggtcgg cggtcatatg tgggtatgac gggtatgacg 1500
tcataaatag tcgttgtcaa aatgggaggt ggaagtcctt actgtagtca cccgtgaagg 1560
tggagaactg gcaggacatc tctaggtcac ctaaacgtgc gaagtgtgcg aaattaccac 1620
cgtaaattcg tcctactgaa agtgcttacg catcttgaga gagattgcag agagccaggt 1680
caaatacatt gagaaatctg tatatgtact ttggtaacgc tctaaggtag gtacacgtta 1740
gtgatataaa aagaaggcga cgacgaactt aaattgttag agcagtttat gggtggtagg 1800
ttacatctat ttacttcaaa acgcggtgcc ctagcccaca agcattgctt tgtaaaattg 1860
ttgaaggtaa cttgtaaaag ccgaacatga acgatggata gtagaccggg aagaccaacg 1920
ttttttcact actccgaaag aacacactga agggaacggt gtaggttcgg tgagtccggg 1980
actaggtgtc catgtcggag acctcagtgg tgacgtcctc gtagtataga aaaaaaaaaa 2040
aaaaaaaaaa aaaaaaaaa 2059
<210> 42
<211> 582
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 42
gcatactgca agacttgtag gcccatgaat tacccgctta ggcaatgggt agacctttcc 60
ttgccgcgtg gaacaaaccg ccatgagtgt tttacgttta cggtcggcga ccggagtcac 120
agcgcgacca acggggccag gcaaaggccc ataggctttt ccatcggcac gcgaccgatt 180
ccatcaagta tagccacggt cgtaacttcg acggcggcaa tagtttatgg cgctaacacc 240
tttccatcgc tgagtccaaa cgtatgacgt gaggtgttag gtgcaatccc cattcgggac 300
ggacacgcga gtaaaggtct aacatgtttc aactttccag ttagtcgccg tcctatattg 360
gcaagaccgg atggccgtca accagttcca ttctgactat ttgccacatt gattaaagaa 420
gtaggagcgt tagtcggcgc gtgcgcggga ctatttagcg aaggtcgccg tatcgcgggt 480
ggcggcgttt ccgccataac aacaagcgtt taaggtcaga gtccgcgacg aatgaaacgc 540
cgtgcaagcg gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 582
<210> 43
<211> 563
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 43
ggcccatgaa ttacccgctt aggcaatggg tagacctttc cttgccgcgt ggaacaaacc 60
gccatgagtg ttttacgttt acggtcggcg accggagtca cagcgcgacc aacggggcca 120
gggaggaagc cttttagcca tcgctatgcc gccgctcaaa cgcgccgggt gcaaaagccc 180
agagcaaagg cccataggct tttccatcgg cacgcgaccg attccatcaa gtgttaggtg 240
caatccccat tcgggacgga cacgcgagag cgttagtcgg cgcgtgcgcg ggactattta 300
gcgaaggtcg ccgatcgttt gcccgtaaaa ctaactggca aaagcctaag tgctgtttcg 360
ggtgcaatgg tataacttcc cacatttagc cgaatagcgc caacagcgtt attatttgga 420
accaagcagt gggcgatgtc agcgacaatt ccactttggt agaggtcgtt cttttgtaga 480
aaacaatcta acataactat gacactttcg gtaaattcac cacctttacc aggaaaaaaa 540
aaaaaaaaaa aaaaaaaaaa aaa 563
<210> 44
<211> 2115
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 44
gcatactgca agacttgtag gcccatgaat tacccgctta ggcaatgggt agacctttcc 60
ttgccgcgtg gaacaaaccg ccatgagtgt tttacgttta cggtcggcga ccggagtcac 120
agcgcgacca acggggccag gcaaaggccc ataggctttt ccatcggcac gcgaccgatt 180
ccatcaagtg ttaggtgcaa tccccattcg ggacggacac gcgagagcgt tagtcggcgc 240
gtgcgcggga ctatttagcg aaggtcgccg atcgtttgcc cgtaaaacta actggcaaaa 300
gcctaagtgc tgtttcgggt gcaatggtat aacttcccac atttagccga atagcgccaa 360
cagcgttatt atttggaacc aagcagtggg cgatgtcagc gacaattcca ctttggtaga 420
ggtcgttctt ttgtagaaaa caatctaaca taactatgac actttcggta aattcaccac 480
ctttaccagg gtcgtaagtg gtcaagccac gccgaccact tcataagcat tggtggaaat 540
cgcatcgaca caataaaagt acaccaacca gcagaaaaca ggtacatata cagtttaacg 600
acctggatct aagatgacta cagtagcata gccatagaac atggcactga aatatcgatg 660
ggcgtaaaag tgaacaacgc agacgatgga ttacgacgcc aagccactat aaatgctaat 720
tgagtcgaag aaggtactcc tttttggaac acagatattg cagaagcggg aatgaggttg 780
atattacatc aagtatcaac agacgacctc agaagggtgg tcttttaaaa tgacaacgta 840
cattaagatg cagacaaaca ctactatgct ggatgtgaaa atgtcatatg tgcggcaaaa 900
atagacgaca tttaagaacc tagcattata ggatggagtg ttgtattaat tcactctaga 960
gtaatggatc acggtgccag aaactaaggt ggtgtaggac tagatgcaag taacaacggt 1020
cgtactaaaa tcagctacgc gatcgccgac ttagaaggct gagatggaga aacttgtcta 1080
ctggcagacc tcactatctt ttaggaaggt cacgaagcgg ctggagtgat ggctagtctc 1140
agccactgtc aacgggaagc gcgacgttta tggtcaatat aaactagcag tttaatccgt 1200
atggcgatct tagcggatgt tacaggatgg agaagatgac aaagtagaag ctagacaact 1260
atatcaaatc gttgtgtggt cttaaaccga cacagtagca ttcatcgttg gatgtggaag 1320
gtcacagcct cgttggagga gatactacgg tcccgctttt cgtgggtgac aaaggtcgca 1380
aaggtttcct tagggaggtc gtttcccgga tctttatcta catctcctgg gtgaagggga 1440
tgatctttct ctacatgtcc tgggtggagg ggagtttcct tgtatgggtg gaacccaacc 1500
cgccggtgag ggtgagttac ggtcggcggt catatgtggg tatgacgggt atgacgtcat 1560
aaatagtcgt tgtcaaaatg ggaggtggaa gtccttactg tagtcacccg tgaaggtgga 1620
gaactggcag gacatctcta ggtcacctaa acgtgcgaag tgtgcgaaat taccaccgta 1680
aattcgtcct actgaaagtg cttacgcatc ttgagagaga ttgcagagag ccaggtcaaa 1740
tacattgaga aatctgtata tgtactttgg taacgctcta aggtaggtac acgttagtga 1800
tataaaaaga aggcgacgac gaacttaaat tgttagagca gtttatgggt ggtaggttac 1860
atctatttac ttcaaaacgc ggtgccctag cccacaagca ttgctttgta aaattgttga 1920
aggtaacttg taaaagccga acatgaacga tggatagtag accgggaaga ccaacgtttt 1980
ttcactactc cgaaagaaca cactgaaggg aacggtgtag gttcggtgag tccgggacta 2040
ggtgtccatg tcggagacct cagtggtgac gtcctcgtag tatagaaaaa aaaaaaaaaa 2100
aaaaaaaaaa aaaaa 2115
<210> 45
<211> 915
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 45
gtatatgtac tttggtaacg ctctaaggta ggtacacgtt agtgatataa aaagaaggcg 60
acgacgaact taaattgtta gagcagttta tgggtggtag gttacatcta tttacttcaa 120
aacgcggtgc cctagcccac aagcattgct ttgtaaaatt gttgaaggta acttgtaaaa 180
gccgaacatg aacgatggat agtagaccgg gaagaccaac gttttttcac tactccgaaa 240
gaacacactg aagggaacgg tgtaggttcg gtgagtccgg gactaggtgt ccatgtcgga 300
gacctcagtg gtgacgtcct cgtagtatag ctgctcgcat gaccagctat atctggaaca 360
tcgctggtgg gtcttatggt cgcttttgtg ggaaccatca tagtcgcaag tctggccttc 420
ggtatggaac tcgtcgtccc gactacaacc atagctagtc tcggtctcgg ctttgttgca 480
atgcccttcg ttactacttc aacggtcgtg gtgccggtca aaccgctcgc taaagcaagc 540
gaagaaacag ctaaacttag ttgtgtcgaa acatcctaag tggtcgggtt gctcgtggag 600
catgcagcta gcccagaacc tttagcttgt gtggtcttcg tctcggtagt cagaaccagg 660
tcggtctgaa tggttggact cgccacatca actaggtcag ctattgaagt gccaactaaa 720
ggtcgtattg aagcaatcgg tcctatggca agtcaagtga cagtcgtagg tatggcactt 780
gccgcgcctc cagaactcgg tcaagctacc tcataactcg gaagtcgact gctctaaagc 840
gaagttgtca aacgaacagc tatgccttcg agtaaagcaa ggtgcaaaaa aaaaaaaaaa 900
aaaaaaaaaa aaaaa 915
<210> 46
<211> 2504
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 46
gcccatgaat tacccgctta ggcaatgggt agacctttcc ttgccgcgtg gaacaaaccg 60
ccatgagtgt tttacgttta cggtcggcga ccggagtcac agcgcgacca acggggccag 120
gcaaaggccc ataggctttt ccatcggcac gcgaccgatt ccatcaagtg ttaggtgcaa 180
tccccattcg ggacggacac gcgagagcgt tagtcggcgc gtgcgcggga ctatttagcg 240
aaggtcgccg atcgtttgcc cgtaaaacta actggcaaaa gcctaagtgc tgtttcgggt 300
gcaatggtat aacttcccac atttagccga atagcgccaa cagcgttatt atttggaacc 360
aagcagtggg cgatgtcagc gacaattcca ctttggtaga ggtcgttctt ttgtagaaaa 420
caatctaaca taactatgac actttcggta aattcaccac ctttaccagg gtcgtaagtg 480
gtcaagccac gccgaccact tcataagcat tggtggaaat cgcatcgaca caataaaagt 540
acaccaacca gcagaaaaca ggtacatata cagtttaacg acctggatct aagatgacta 600
cagtagcata gccatagaac atggcactga aatatcgatg ggcgtaaaag tgaacaacgc 660
agacgatgga ttacgacgcc aagccactat aaatgctaat tgagtcgaag aaggtactcc 720
tttttggaac acagatattg cagaagcggg aatgaggttg atattacatc aagtatcaac 780
agacgacctc agaagggtgg tcttttaaaa tgacaacgta cattaagatg cagacaaaca 840
ctactatgct ggagtgttgt attaattcac tctagagtaa tggatcacgg tgccagaaac 900
taaggtggtg taggactaga tgcaagtaac aacggtcgta ctaaaatcag ctacgcgatc 960
gccgacttag aaggctgaga tggagaaact tgtctactgg cagacctcac tatcttttag 1020
gaaggtcacg aagcggctgg agtgatggct agtctcagcc actgtcaacg ggaagcgcga 1080
cgtttatggt caatataaac tagcagttta atccgtatgg cgatcttagc ggatgttaca 1140
ggatggagaa gatgacaaag tagaagctag acaactatat caaatcgttg tgtggtctta 1200
aaccgacaca gtagcattca tcgttggatg tggaaggtca cagcctcgtt ggaggagata 1260
ctacggtccc gcttttcgtg ggtgacaaag gtcgcaaagg tttccttagg gaggtcgttt 1320
cccggatctt tatctacatc tcctgggtga aggggatgat ctttctctac atagattgca 1380
gagagccagg tcaaatacat tgagaaatct gtatatgtac tttggtaacg ctctaaggta 1440
ggtacacgtt agtgatataa aaagaaggcg acgacgaact taaattgtta gagcagttta 1500
tgggtggtag gttacatcta tttacttcaa aacgcggtgc cctagcccac aagcattgct 1560
ttgtaaaatt gttgaaggta acttgtaaaa gccgaacatg aacgatggat agtagaccgg 1620
gaagaccaac gttttttcac tactccgaaa gaacacactg aagggaacgg tgtaggttcg 1680
gtgagtccgg gactaggtgt ccatgtcgga gacctcagtg gtgacgtcct cgtagtatag 1740
gtccacgctc taagtcgctt gcccaattgt ggctaccgca ttgctcagaa cttcgggtac 1800
tggccaacct tcaagaagcc tagtcttggt gcgtcacccc agtcacgtag catacccgtc 1860
atcatctatg gtcgtaggtc caacaatcgt ggcgccattg ggtaccactt catcagagct 1920
gctcgcatga ccagctatat ctggaacatc gctggtgggt cttatggtcg cttttgtggg 1980
aaccatcata gtcgcaagtc tggccttcgg tatggaactc gtcgtcccga ctacaaccat 2040
agctagtctc ggtctcggct ttgttgcaat gcccttcgtt actacttcaa cggtcgtggt 2100
gccggtcaaa ccgctcgcta aagcaagcga agaaacagct aaacttagtt gtgtcgaaac 2160
atcctaagtg gtcgggttgc tcgtggagca tgcagctagc ccagaacctt tagcttgtgt 2220
ggtcttcgtc tcggtagtca gaaccaggtc ggtctgaatg gttggactcg ccacatcaac 2280
taggtcagct attgaagtgc caactaaagg tcgtattgaa gcaatcggtc ctatggcaag 2340
tcaagtgaca gtcgtaggta tggcacttgc cgcgcctcca gaactcggtc aagctacctc 2400
ataactcgga agtcgactgc tctaaagcga agttgtcaaa cgaacagcta tgccttcgag 2460
taaagcaagg tgcgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 2504
<210> 47
<211> 576
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 47
gcatactgca agacttgtag gcccatgaat tacccgctta ggcaatgggt agacctttcc 60
ttgccgcgtg gaacaaaccg ccatgagtgt tttacgttta cggtcggcga ccggagtcac 120
agcgcgacca acgggcaaag gcccataggc ttttccatcg gcacgcgacc gattccatca 180
agtatagcca cggtcgtaac ttcgacggcg gcaatagttt atggcgctaa cacctttcca 240
tcgctgagtc caaacgtatg acgtgaggtg ttaggtgcaa tccccattcg ggacggacac 300
gcgagtaaag gtctaacatg tttcaacttt ccagttagtc gccgtcctat attggcaaga 360
ccggatggcc gtcaaccagt tccattctga ctatttgcca cattgattaa agaagtagga 420
gcgttagtcg gcgcgtgcgc gggactattt agcgaaggtc gccgtatcgc gggtggcggc 480
gtttccgcca taacaacaag cgtttaaggt cagagtccgc gacgaatgaa acgccgtgca 540
agcggcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa 576
<210> 48
<211> 259
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 48
gtaccaaagc cgcttgcacg gcgtttcatt cgtcgcggac tctgacctta aacgcttgtt 60
gttatggcgg aaacgccgcc acccgcgata cggcgacctt cgctaaatag tcccgcgcac 120
gcgccgacta acgctcctac ttctttaatc aatgtggcaa atagtcagaa tggaactggt 180
tgacggccat ccggtcttgc caatatagga cggcgactaa ctggaaagta aaaaaaaaaa 240
aaaaaaaaaa aaaaaaaaa 259
<210> 49
<211> 1465
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 49
ggcaagacga atctgcgtca acgctaaagg ccgtcaaaaa gcaagagggc gtcgcgcctg 60
ggaaaaaggt agtcaagaaa ccatcaagct taaatgtcgg gaaattgggt ttgcgccgcc 120
ttcaggggca gcgatggggg cgacaattgt ggaccgtatg gactccatta tgctgggact 180
cctcgggtca accgctctaa agcgaagttg ttggacaaac agttatgcgt aactgtaaag 240
caaggtgccc aaagtagact gagcgacagt cgaaaccagc cccaatgaac aagacgccat 300
tgcaaaacgt ctatacgcta cggtcaaaga cgcttccaca ccacatgttg tgctcgccat 360
ttcaactagt gcagttgcta aagtgccaac taaggttcgt cttgaagcaa tcggtagtat 420
ctgcagtcaa gtcgtagtcg taggtatggc acttgtcgtg cgtctaggac gcgttgaagc 480
tatcttattg cccgaaggag ccgaaagtct gggacacgtc gtgggacgta tcgttaggac 540
tatgggacta gtcgtcttcg gtcttacaaa tgttgcaatg ccctgtgagc tacttatgaa 600
acatgaatgg tcggtcttgt ggtcgctttt gtcgaaatca ccgaagtgcg tataattgat 660
gaacgagtcg aagtcgaagt tgttcaacaa gagagttagg tagtgccgct tgaaaaagta 720
atagtgcaaa taagaaaaag aagcgaaacg gcattcgttt aacaaaacgt cacatattta 780
ggtatagtag attgcgttca caaagaaatt taaatttaat ttaccatttc gtcattgtat 840
atgcggtaaa cgtaaattta cacatatgac acgaactttg agttttatta gcctgcctaa 900
ttgttggtaa caatgtaatg gaaattggcg atgactatgg ggaaagagca atcaactcac 960
cataaatttg tgaacgcagt taagtaattg gcatcgcgcg cctaatcgtt tacattcgca 1020
tggaacaaga agaaagagac ctattcgtgg gagtcaatgg ctatgtggaa aaacatgaac 1080
tgccaaattc ggctaaccaa ccagaaatgg tcatggaaaa ttcttgcgtc aaagttcgcg 1140
gtgacgttta cgaagaagct aaacttgtgc ttgtttagaa agttaggtgc gtcctggttt 1200
tagtaaattt agaaaaccat tttgttgttt gcgacagtta aataaaactt aacgacaaag 1260
aagtgacttg cgtcgtagat taactggaaa ttaaagtggt atctaaaatg gggtttgccg 1320
atgcggtctt caaagtctaa aattcttgaa gtttgcgttt ggtcgcaaaa attatggatt 1380
tagtcgatta ttgcctacta agcagcagtt tagaagtttt taagatagtt acgctaaaaa 1440
aaaaaaaaaa aaaaaaaaaa aaaaa 1465
<210> 50
<211> 604
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 50
ggggcagcga tgggggcgac aattgtggac cgtatggact ccattatgct gggactcctc 60
gggtcaaccg ctctaaagcg aagttgttgg acaaacagtt atgcgtaact gtaaagcaag 120
gtgcccaaag tagactgagc gacagtcgaa accagcccca atgaacaaga cgccattgca 180
aaacgtctat acgctacggt caaagacgct tccacaccac atggactatg ggactagtcg 240
tcttcggtct tacaaatgtt gcaatgccct gtgagctact tatgaaacat gaatggtcgg 300
tcttgtggtc gcttttgtcg aaatcaccga agtgcgtata attgatgaac gagtcgaagt 360
cgaagttgtt caacaagaga gttaggtagt gccgcttgaa aaagtaatag tgcaaataag 420
aaaaagaagc gaaacggcat tcgtttaaca aaacgtcaca tatttaggta tagtagattg 480
cgttcacaaa gaaatttaaa tttaatttac catttcgtca ttgtatatgc ggtaaacgta 540
aatttacaca tatgacacga actttgagtt ttataaaaaa aaaaaaaaaa aaaaaaaaaa 600
aaaa 604
<210> 51
<211> 1999
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 51
gtgggtttat atcgcgtatc catccaactt aactgaaacg cgaagcagta gacagtgttg 60
atcgagattt gcgaagggaa acagtaaaag tccagggtgt cgttaattac gacaaaacta 120
aagactgtat agttagaagg atcaattggg ctgatttaga aatggtataa gttaaagaaa 180
tggaaactta ttcgacaaaa agaaaaactc atgatgtata gatggaaact gccataatgt 240
cgattcgagt tatattttta gattttggta aaatatccaa catgtattaa cgaaattttg 300
aagtatagat caaactattc ttcaggtaca gcatcaagca ttcggtagca taagccaaac 360
aagtctttga agggttggac atagcgagtt gtgtagaaag ttacgaagac ttcaacagaa 420
aaagagttta aaaggaccac gtatgccaaa tcgacaacaa tatagtcgtt ctattctgcg 480
atatgtaaga tagagacaca tcggcaggta gcatagaact tgggtcaatt attatttaag 540
tgcggtaaca aacaaactta gggaatatta ttgtgctaca gcaaatgcct tgaaaagtcg 600
agaaagacta ctatactcgt caagttcgta aagacttaac agtaattgta atgcaaatac 660
ttagcgagat tgattccttc ccagtagtca tctttccttt agatattaga acagcaattt 720
tagattttgt acatagtgga gaaaaggacg tcattttaat ggatgaacca gacgttaacg 780
tcatttactt ggtcgttgat ttcgaagact cagtcatcaa aattgtagct tcgctagcta 840
atgtgcttaa aatcatcata gtcaaagtgt acgtggtcgt ggtaataaac aaccttcatt 900
actgtacaaa agtgccagtt tgttacatta tcgaacgctg tatagaggta tcatttcacc 960
tatttgacaa ctaggtgata aaccttcggt cgctagacgt tgttgttatt gaaaaaatgg 1020
aagataatct atacttaatc caaaacaacc cagaccaagc tcgtatataa atggaagtcg 1080
tcaaaattgg tttcgttcaa ataagttggg actgatgaat cagttttctg aacttcaccg 1140
ctattagcgt cctagttgtc tacataatta gtatcattat tgtagtagtt taaatcgcta 1200
acaaccaaaa aatccttgac atgggtaacg acgttattgg ggaaccaatg ctcagtgttg 1260
gtgaaagaat cgttaggtcg aactattggt acgttctaat aaaagacgac atagaaattc 1320
gttacataat caacgtcact actaagggcg tattgcaaat tagttcataa attattaaca 1380
gtttgcacct aatagttcta gtccttaaaa aggtagaaga cgtaggtaat gtcagttgcc 1440
tcaatgtagt caggtaaaaa gtatatgtgc tgatggcaaa cttcatcttt gtgagagttg 1500
agcatgtata acaacatcac tcagtataac cgcttggtta cacaattagt atcatgccta 1560
tagaacgcct tatcattcag gtcgtcgtga tagtgaaggg gatcaaagtc aaaatctact 1620
ttgtcataac tctttacggt atcccaatgc ttggtataag tgcttaagaa attgtttaaa 1680
cagaaactca agtataagcg aaaacaagtt acctggaaaa agaagaagtg cgtataattg 1740
atgaacgagt cgaagtcgaa gttgttcaac aagagagtta ggtagtgccg cttgaaaaag 1800
taatagtgca aataagaaag taagactgta tcggagacga ctttttaata gtagtaattc 1860
tcggtacaac taaaccagta atttcagaca ctgaaataga ggacttcgtt aggtacgaag 1920
caagttaact aaatgacaat taaattgagg gtaaatatca caaagaaata aaaaaaaaaa 1980
aaaaaaaaaa aaaaaaaaa 1999
<210> 52
<211> 1567
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 52
gcttaaatgt cgggaaattg ggtttgcgcc gccttcaggg gcagcgatgg gggcgacaat 60
tgtggaccgt atggactcca ttatgctggg actcctcggg tcaaccgctc taaagcgaag 120
ttgttggaca aacagttatg cgtaactgta aagcaaggtg cccaaagtag actgagcgac 180
agtcgaaacc agccccaatg aacaagacgc cattgcaaaa cgtctatacg ctacggtcaa 240
agacgcttcc acaccacatg ctctcatgta gcctacctta cgaagaaatc gcacaagtcg 300
gtcgcccagc ggtggcatat gtcttgccta acgtttctag accgatcagc ctcacgagta 360
gcctgcttgt ggtgtttata gtttacgcta gtccaatctg tatcgtgccg cttggtatgg 420
ctattgtcgg cctggatgca attgtgctcg ccatttcaac tagtgcagtt gctaaagtgc 480
caactaaggt tcgtcttgaa gcaatcggta gtatctgcag tcaagtcgta gtcgtaggta 540
tggcacttgt cgtgcgtcta ggacgcgttg aagctatctt attgcccgaa ggagccgaaa 600
gtctgggaca cgtcgtggga cgtatcgtta ggactatggg actagtcgtc ttcggtctta 660
caaatgttgc aatgccctgt gagctactta tgaaacatga atggtcggtc ttgtggtcgc 720
ttttgtcgaa atcaccgaag tgcgtataat tgatgaacga gtcgaagtcg aagttgttca 780
acaagagagt taggtagtgc cgcttgaaaa agtaatagtg caaataagaa aaagcgaaac 840
ggcattcgtt taacaaaacg tcacatattt aggtatagta gattgcgttc acaaagaaat 900
ttaaatttaa tttaccattt cgtcattgta tatgcggtaa acgtaaattt acacatatga 960
cacgaacttt gagttttatt agcctgccta attgttggta acaatgtaat ggaaattggc 1020
gatgactatg gggaaagagc aatcaactca ccataaattt gtgaacgcag ttaagtaatt 1080
ggcatcgcgc gcctaatcgt ttacattcgc atggaacaag aagaaagaga cctattcgtg 1140
ggagtcaatg gctatgtgga aaaacatgaa ctgccaaatt cggctaacca accagaaatg 1200
gtcatggaaa attcttgcgt caaagttcgc ggtgacgttt acgaagaagc taaacttgtg 1260
cttgtttaga aagttaggtg cgtcctggtt ttagtaaatt tagaaaacca ttttgttgtt 1320
tgcgacagtt aaataaaact taacgacaaa gaagtgactt gcgtcgtaga ttaactggaa 1380
attaaagtgg tatctaaaat ggggtttgcc gatgcggtct tcaaagtcta aaattcttga 1440
agtttgcgtt tggtcgcaaa aattatggat ttagtcgatt attgcctact aagcagcagt 1500
ttagaagttt ttaagatagt tacgctagaa gaccgggaaa aaaaaaaaaa aaaaaaaaaa 1560
aaaaaaa 1567
<210> 53
<211> 1118
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 53
gcgatggggg cgacaattgt ggaccgtatg gactccatta tgctgggact cctcgggtca 60
accgctctaa agcgaagttg ttggacaaac agttatgcgt aactgtaaag caaggtgccc 120
aaagtagact gagcgacagt cgaaaccagc cccaatgaac aagacgccat tgcaaaacgt 180
ctatacgcta cggtcaaaga cgcttccaca ccacatgctc tcatgtagcc taccttacga 240
agaaatcgca caagtcggtc gcccagcggt ggcatatgtc ttgcctaacg tttctagacc 300
gatcagcctc acgagtagcc tgcttgtggt gtttatagtt tacgctagtc caatctgtat 360
cgtgccgctt ggtatggcta ttgtcggcct ggatgcaatt gtgctcgcca tttcaactag 420
tgcagttgct aaagtgccaa ctaaggttcg tcttgaagca atcggtagta tctgcagtca 480
agtcgtagtc gtaggtatgg cacttgtcgt gcgtctagga cgcgttgaag ctatcttatt 540
gcccgaagga gccgaaagtc tgggacacgt cgtgggacgt atcgttagga ctatgggact 600
agtcgtcttc ggtcttacaa atgttgcaat gccctgtgag ctacttatga aacatgaatg 660
gtcggtcttg tggtcgcttt tgtcgaaatc accgaagtgc gtataattga tgaacgagtc 720
gaagtcgaag ttgttcaaca agagagttag gtagtgccgc ttgaaaaagt aatagtgcaa 780
ataagaaaaa gaagcgaaac ggcattcgtt taacaaaacg tcacatattt aggtatagta 840
gattgcgttc acaaagaaat ttaaagtctt gtaattatgg tggtcgattt attggtagta 900
tatttggaaa tagcatgcaa ttttggaatg gacgaagaac ctgacatctg agctattgta 960
agtttaattt accatttcgt cattgtatat gcggtaaacg taaatttaca catatgacac 1020
gaactttgag ttttattagc ctgcctaatt gttggtaaca atgtaatgga aattggcgat 1080
gactatggaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 1118
<210> 54
<211> 575
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 54
gaatattgtt tcaatggtcg tggcgctggt cagactgctc gctaaagtcg tcgaagaaac 60
agctagacca tctattctct gaacttccta agtggtcggg ttggtcgtgg cgctcatagt 120
tagcccagaa cgtccagttt atgtggtggt gatcttggtt gccagactca gtatggtcaa 180
aatagttgtg ctcgccattt caactagtgc agttgctaaa gtgccaacta aggttcgtct 240
tgaagcaatc ggtagtatct gcagtcaagt cgtagtcgta ggtatggcac ttgtcgtgcg 300
tctaggacgc gttgaagcta tcttattgcc cgaaggagcc gaaagtctgg gacacgtcgt 360
gggacgtatc gttaggacta tgggactagt cgtcttcggt cttacaaatg ttgcaatgcc 420
ctgtgagcta cttatgaaac atgaatggtc ggtcttgtgg tcgcttttgt cgaaatcacc 480
gaagtgcgta taattgatga acgagtcgaa gtcgaagttg ttcaacaaga gagttaggta 540
gtgccaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 575
<210> 55
<211> 604
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 55
gcgatggggg cgacaattgt ggaccgtatg gactccatta tgctgggact cctcgggtca 60
accgctctaa agcgaagttg ttggacaaac agttatgcgt aactgtaaag caaggtgccc 120
aagtagactc ttactaattt gggaacgacg gaaagtcgct accttcatcg gtatggcttt 180
cgctaaagtc ggtcaaatgg aagaaggtag tcgaagtact gttgaaagag tagactgagc 240
gacagtcgaa accagcccca atgaacaaga cgccattgca aaacgtctat acgctacggt 300
caaagacgct tccacaccac atgctctcat gtagcctacc ttacgaagaa atcgcacaag 360
tcggtcgccc agcggtggca tatgtcttgc ctaacgtttc tagaccgatc agcctcacga 420
gtagcctgct tgtggtgttt atagtttacg ctagtccaat ctgtatcgtg ccgcttggta 480
tggctattgt cggcctggat gcaattgtgc tcgccatttc aactagtgca gttgctaaag 540
tgccaactaa ggttcgtctt gaagcaatcg gtagaaaaaa aaaaaaaaaa aaaaaaaaaa 600
aaaa 604
<210> 56
<211> 407
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 56
gcctatgcct cgtatcatct atggtcgtag gtaaagcaat agcggaaaca ttggatgtga 60
cttcatcagg actgctcgta tagtgagcta cttatgaaac atgaatggtc ggtcttgtgg 120
tcgcttttgt cgaaatcacc gaagtgcgta taattgatga acgagtcgaa gtcgaagttg 180
ttcaacaaga gagttaggta gtgccgcttg aaaaagtaat agtgcaaata agaaaaagaa 240
gcgaaacggc attcgtttaa caaaacgtca catatttagg tatagtagat tgcgttcaca 300
aagaaattta aatttaattt accatttcgt cattgtatat gcggtaaacg taaatttaca 360
catatgacac gaactttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 407
<210> 57
<211> 515
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 57
gggcgacaat tgtggaccgt atggactcca ttatgctggg actcctcggg tcaaccgctc 60
taaagcgaag ttgttggaca aacagttatg cgtaactgta aagcaaggtg cccaaagtag 120
actgagcgac agtcgaaacc agccccaatg aacaagacgc cattgcaaaa cgtctatacg 180
ctacggtcaa agacgcttcc acaccacatg ctctcatgta gcctacctta cgaagaaatc 240
gcacaagtcg gtcgcccagc ggtggcatat gtcttgccta acgtttctag accgatcagc 300
ctcacgagta gcctgcttgt ggtgtttata gtttacgcta gtccaatctg tatcgtgccg 360
cttggtatgg ctattgtcgg cctggatgca agcactaacg tggtcatcag actggtctgc 420
gctataatct acgcaataga ggcaccagcg gtcgttgaag ccgaagacgc tatttcggtg 480
gcttgaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 515
<210> 58
<211> 1193
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 58
gtgctcgcca tttcaactag tgcagttgct aaagtgccaa ctaaggttcg tcttgaagca 60
atcggtagta tctgcagtca agtcgtagtc gtaggtatgg cacttgtcgt gcgtctagga 120
cgcgttgaag ctatcttatt gcccgaagga gccgaaagtc tgggacacgt cgtgggacgt 180
atcgttagga ctatgggact agtcgtcttc ggtcttacaa atgttgcaat gccctgtgag 240
ctacttatga aacatgaatg gtcggtcttg tggtcgcttt tgtcgaaatc accgaagtgc 300
gtataattga tgaacgagtc gaagtcgaag ttgttcaaca agagagttag gtagtgccgc 360
ttgaaaaagt aatagtgcaa ataagaaagt aagactgtat cggagacgac tttttaatag 420
tagtaattct cggtacaact aaaccagtaa tttcagacac tgaaatagag gacttcgtta 480
ggtacgaagc aagttaacta aatgacaatt aaattgaggg taaatatcac aaagaaatca 540
tggaagattt cgaccgaata caggaaaatt tagattaaag gtttgtcgtc gttgaaataa 600
gaagaagcga aacggcattc gtttaacaaa acgtcacata tttaggtata gtagattgcg 660
ttcacaaaga aatttaaatt taatttacca tttcgtcatt gtatatgcgg taaacgtaaa 720
tttacacata tgacacgaac tttgagtttt attagcctgc ctaattgttg gtaacaatgt 780
aatggaaatt ggcgatgact atggggaaag agcaatcaac tcaccataaa tttgtgaacg 840
cagttaagta attggcatcg cgcgcctaat cgtttacatt cgcatggaac aagaagaaag 900
agacctattc gtgggagtca atggctatgt ggaaaaacat gaactgccaa attcggctaa 960
ccaaccagaa atggtcatgg aaaattcttg cgtcaaagtt cgcggtgacg tttacgaaga 1020
agctaaactt gtgcttgttt agaaagttag gtgcgtcctg gttttagtaa atttagaaaa 1080
ccattttgtt gtttgcgaca gttaaataaa acttaacgac aaagaagtga cttgcgtcgt 1140
agattaactg gaaattaaag tggaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1193
<210> 59
<211> 484
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 59
ggtagttgtt gaaaaagtag gaatatctag cctagatgtc gtttcaggcg aaggactcta 60
aggtcttaaa atcgttgggt caaccgctct aaagcgaagt tgttggacaa acagttatgc 120
gtaactgtaa agcaaggtgc ccaaagtaga ctgagcgaca gtcgaaacca gccccaatga 180
acaagacgcc attgcaaaac gtctatacgc tacggtcaaa gacgcttcca caccacatgg 240
tatagtggac gccgttagcc tcatgtgtct cactcaaaga ccttgcgtca cggtcatcct 300
ctttgtcagc aacgtagaaa tctccggtct gtcgatacct tgcgtaaagc tctcatgtag 360
cctaccttac gaagaaatcg cacaagtcgg tcgcccagcg gtggcatatg tcttgcctaa 420
cgtttctaga ccgatcagcc tcacgagtag cctgaaaaaa aaaaaaaaaa aaaaaaaaaa 480
aaaa 484
<210> 60
<211> 1558
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 60
gcttaaatgt cgggaaattg ggtttgcgcc gccttcaggg gcagcgatgg gggcgacaat 60
tgtggaccgt atggactcca ttatgctggg actcctcggg tcaaccgctc taaagcgaag 120
ttgttggaca aacagttatg cgtaactgta aagcaaggtg cccaaagtag actgagcgac 180
agtcgaaacc agccccaatg aacaagacgc cattgcaaaa cgtctatacg ctacggtcaa 240
agacgcttcc acaccacatg ctctcatgta gcctacctta cgaagaaatc gcacaagtcg 300
gtcgcccagc ggtggcatat gtcttgccta acgtttctag accgatcagc ctcacgagta 360
gcctgcttgt ggtgtttata gtttacgcta gtccaatctg tatcgtgccg cttggtatgg 420
ctattgtcgg cctggatgca attgtgctcg ccatttcaac tagtgcagtt gctaaagtgc 480
caactaaggt tcgtcttgaa gcaatcggta gtatctgcag tcaagtcgta gtcgtaggta 540
tggcacttgt cgtgcgtcta ggacgcgttg aagctatctt attgcccgaa ggagccgaaa 600
gtctgggaca cgtcgtggga cgtatcgtta ggactatggg actagtcgtc ttcggtctta 660
caaatgttgc aatgccctgt gagctactta tgaaacatga atggtcggtc ttgtggtcgc 720
ttttgtcgaa atcaccgaag tgcgtataat tgatgaacga gtcgaagtcg aagttgttca 780
acaagagagt taggtagtgc cgcttgaaaa agtaatagtg caaataagaa aaagaagcga 840
aacggcattc gtttaacaaa acgtcacata tttaggtata gtagattgcg ttcacaaaga 900
aatttaaatt taatttacca tttcgtcatt gtatatgcgg taaacgtaaa tttacacata 960
tgacacgaac tttgagtttt attagcctgc ctaattgttg gtaacaatgt aatggaaatt 1020
ggcgatgact atggggaaag agcaatcaac tcaccataaa tttgtgaacg cagttaagta 1080
attggcatcg cgcgcctaat cgtttacatt cgcatggaac aagaagaaag agacctattc 1140
gtgggagtca atggctatgt ggaaaaacat gaactgccaa attcggctaa ccaaccagaa 1200
atggtcatgg aaaattcttg cgtcaaagtt cgcggtgacg tttacgaaga agctaaactt 1260
gtgcttgttt agaaagttag gtgcgtcctg gttttagtaa atttagaaaa ccattttgtt 1320
gtttgcgaca gttaaataaa acttaacgac aaagaagtga cttgcgtcgt agattaactg 1380
gaaattaaag tggtatctaa aatggggttt gccgatgcgg tcttcaaagt ctaaaattct 1440
tgaagtttgc gtttggtcgc aaaaattatg gatttagtcg attattgcct actaagcagc 1500
agtttagaag tttttaagat agttacgcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 1558
<210> 61
<211> 1341
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 61
gtgagctact tatgaaacat gaatggtcgg tcttgtggtc gcttttgtcg aaatcaccgg 60
aaacattaaa tcaaagaagt ttatcaacca attagtacag tggcatgtta agtaaaacag 120
aaagaacgcc aagtggcaac aaatgacgta attatttaag caaaaagcgt aaacgcttac 180
aaaggctatt taaatatcag taaatcgttg gaaattgggt atgtgctgcc ttcatacgca 240
aaaatggatg cgacagaaac gagttgtatg gcctccacta cgctcgcctg ccgcggaccc 300
taaacgacag tcgtttgccc aactacggct acggcatcgc tcagaacttc gggtcttggc 360
ccacctttct gacgcctagt caacgtgcgt cgcctcagtc ttggacaaaa agaagaaata 420
tcaattgcaa aaataactat aggtacttct ttgaagaaac caaacgtgag tttctaacac 480
gactaaatcc atttgatctt tgagaaagtc gaagacgaat gaagtgcgta taattgatga 540
acgagtcgaa gtcgaagttg ttcaacaaga gagttaggta gtgccgcttg aaaaagtaat 600
agtgcaaata agaaaaagaa gcgaaacggc attcgtttaa caaaacgtca catatttagg 660
tatagtagat tgcgttcaca aagaaattta aatttaattt accatttcgt cattgtatat 720
gcggtaaacg taaatttaca catatgacac gaactttgag ttttattagc ctgcctaatt 780
gttggtaaca atgtaatgga aattggcgat gactatgggg aaagagcaat caactcacca 840
taaatttgtg aacgcagtta agtaattggc atcgcgcgcc taatcgttta cattcgcatg 900
gaacaagaag aaagagacct attcgtggga gtcaatggct atgtggaaaa acatgaactg 960
ccaaattcgg ctaaccaacc agaaatggtc atggaaaatt cttgcgtcaa agttcgcggt 1020
gacgtttacg aagaagctaa acttgtgctt gtttagaaag ttaggtgcgt cctggtttta 1080
gtaaatttag aaaaccattt tgttgtttgc gacagttaaa taaaacttaa cgacaaagaa 1140
gtgacttgcg tcgtagatta actggaaatt aaagtggtat ctaaaatggg gtttgccgat 1200
gcggtcttca aagtctaaaa ttcttgaagt ttgcgtttgg tcgcaaaaat tatggattta 1260
gtcgattatt gcctactaag cagcagttta gaagttttta agatagttac gaaaaaaaaa 1320
aaaaaaaaaa aaaaaaaaaa a 1341
<210> 62
<211> 489
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 62
ggttcgtctt gaagcaatcg gtagtatctg cagtcaagtc gtagtcgtag gtatggcact 60
tgtcgtgcgt ctaggacgcg ttgaagctat cttattgccc gaaggagccg aaagtctggg 120
acacgtcgtg ggacgtatcg ttaggactat gggactagtc gtcttcggtc ttacaaatgt 180
tgcaatgccc tgtgagctac ttatgaaaca tgaatggtcg gtcttgtggt cgcttttgtc 240
gaaatcaccg gacaaaaaga agaaatatca attgcaaaaa taactatagg tacttctttg 300
aagaaaccaa acgtgagttt ctaacacgac taaatccatt tgatctttga gaaagtcgaa 360
gacgaatgaa gtgcgtataa ttgatgaacg agtcgaagtc gaagttgttc aacaagagag 420
ttaggtagtg ccgcttgaaa aagtaatagt gcaaataaga aaaaaaaaaa aaaaaaaaaa 480
aaaaaaaaa 489
<210> 63
<211> 813
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 63
ggggaaccaa tgctcagtgt tggtgaaaga atcgttaggt cgaactattg gtacgttcta 60
ataaaagacg acatagaaat tcgttacata atcaacgtca ctactaaggg cgtattgcaa 120
attagttcat aaattattaa cagtttgcac ctaatagttc tagtccttaa aaaggtagaa 180
gacgtaggta atgtcagttg cctcaatgta gtcaggtaaa aagtatatgt gctgatggca 240
aacttcatct ttgtgagagt tgagcatgta taacaacatc actcagtata accgcttggt 300
tacacaatta gtatcatgcc tatagaacgc cttatcattc aggtcgtcgt gatagtgaag 360
gggatcaaag tcaaaatcta ctttgtcata actctttacg gtatcccaat gcttggtata 420
agtgcttaag aaattgttta aacagaaact caagtataag cgaaaacaag ttacctggaa 480
aaagaagaag tgcgtataat tgatgaacga gtcgaagtcg aagttgttca acaagagagt 540
taggtagtgc cgcttgaaaa agtaatagtg caaataagaa aaagaagcga aacggcattc 600
gtttaacaaa acgtcacata tttaggtata gtagattgcg ttcacaaaga aatttaaatt 660
taatttacca tttcgtcatt gtatatgcgg taaacgtaaa tttacacata tgacacgaac 720
tttgagtttt attagcctgc ctaattgttg gtaacaatgt aatggaaatt ggcgatgact 780
atgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 813
<210> 64
<211> 561
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 64
gaatattgtt tcaatggtcg tggcgctggt cagactgctc gctaaagtcg tcgaagaaac 60
agctagacca tctattctct gaacttccta agtggtcggg ttggtcgtgg cgctcatagt 120
tagcccagaa cgtccagttt atgtggtggt gatcttggtt gccagactca gtatggtcaa 180
aatagttgtg ctcgccattt caactagtgc agttgctaaa gtgccaacta aggttcgtct 240
tgaagcaatc ggtagtatct gcagtcaagt cgtagtcgta ggtatggcac ttgtcgtgcg 300
tctaggacgc gttgaagcta tcttattgcc cgaaggagcc gaaagtctgg gacacgtcgt 360
gggacgtatc gttaggacta tgggactagt cgtcttcggt cttacaaatt gagctactta 420
tgaaacatga atggtcggtc ttgtggtcgc ttttgtcgaa atcaccgaag tgcgtataat 480
tgatgaacga gtcgaagtcg aagttgttca acaagagagt taggtagtgc caaaaaaaaa 540
aaaaaaaaaa aaaaaaaaaa a 561
<210> 65
<211> 306
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 65
gagatttcta cgttgctgac aaagaggatg accgtgacgc aaggtctttg agtgagacac 60
atgaggctaa cggcgtccac tataccatgt ggtgtggaag cgtctttgac cgtagcgtat 120
agacgttttg caatggcgtc ttgttcattg gggctggttt cgactgtcgc tcagtctact 180
ctttcaacag tacttcgact accttcttcc atttgaccga ctttagcgaa agccataccg 240
atgaaggtag cgactttccg tcgttcccaa attagtaaaa aaaaaaaaaa aaaaaaaaaa 300
aaaaaa 306
<210> 66
<211> 219
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 66
gcagatacta ccgattgctt caagacgaac cttagttggc actttagcaa ctgcactagt 60
tgaaatggcg agcacaacta ttttgaccat actgagtctg gcaaccaaga tcaccaccac 120
ataaactgga cgttctgggc taactatgag cgccacgacc aacccgacca cttaggaagt 180
tcagagaata aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 219
<210> 67
<211> 2492
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 67
gagacgatga aacttgagaa atcgcactgg cttacatata cacgataaaa gactttaata 60
caatataaga agtcgttatt gaagacggag atgtatgtta ccgcccaatt ttagagatac 120
aaaatgagac tgacatagcg gttaactata ttagagcacg cctaagcatt gaaggtttag 180
tcatcttcat tagagtatac tgtattgacg gctgaatgca aataaattga gacaaaaccg 240
atttcttgaa ttagcacgaa gtaagtataa aactagtaga gtgacaccaa gtatataggg 300
ggtttatatc gcgtggaatc gaacaacata tctatttaat tagtttaata acaaattaag 360
tgacttatcg cggaagagag aacaatagat tggattaaaa agttgtagta aaccacaacg 420
aagttaggta gctggtaagg ttatagatgc gttctgtcgt tgtagtccca atgaacatag 480
tatggtttcg catagtaact gacctaaaag accgccacat agtgaaaata cttaaaacgc 540
aagtttcata ggattaagtg gtagaggcta tagaaaatga tatcataact ataacgaata 600
taacagcaaa ttaaaatgca ctggaagtgg aaaatttcag caagagagtc gaagtcgtca 660
tagattagca tggataatgg caattatagt taaaatagtc gtaaattaga ttatggtgca 720
ccggggtgta agtttcgaac tcggtgaggc aatagtagta tagactaaca acaaggtaga 780
cattgcaatg tattgcgaga agaacttcac gaagatatag atacagtaca gaatttctag 840
gattaagtac agcagacgta tttacacctg ttataggata cttgttcact taatccctgt 900
tatgacaaag tagtctcata gaatttttag aacgagaaga tttgaatgga cgtaaaggaa 960
gaaggtcaaa atggagaact taaaagggga aatctagaac attgaaccca acattataca 1020
atgatataag aacgaaaaga cgaagacaat aaggtccatg ggatttaccc aaatgaggac 1080
ctaaatcacc gggaagaagt aagtaaacat aacgatatag ttttagatta tcgagaagtc 1140
gaagaagacc gggataggta acagataatc gacgtttggg aagacggtaa cgtaagaaac 1200
tgaggaggtt aaagaactaa gaatcaacaa caagaaacta ttgtccctat tctacttagg 1260
tatctgctag tatgcgatat ggaagttaaa gaggaaacag tagtatgcac tgtttgagaa 1320
aattaggatt taagaggtgg agaagtcgtt agtttggaag catagatagt tcaaatatcc 1380
acagaaggct attaaaagat agaagagagt cgagagatcg attttaaagt ctgagtcgaa 1440
atagtttggt gcaagattat ccattcaatt cttatcgaaa acttacaagg tcaacaagta 1500
gagatagcaa tataactaaa agctatctat tgaacataaa tgcgcgacta cagcttgcgg 1560
gttaacacgg tcgtcttcat tatacgttta atcgacgccg gcttattcat gcagatattt 1620
aactcaatct tcgataggat agaggacgta gtagacttgg atgtctgtca tccagacatg 1680
agacatatac ttatatggat aatggtagtg cagcaaagtc gtataattta aacggtatgg 1740
gacgaagcta acaacataga ggtggacaac gtatagcagg taattgttaa acttgttctg 1800
gaaataaaga aagaaatctt ttggactatg ggcgtggcat tagtatcaag agtagtcttg 1860
gtttgtatta tattggcagt gagcttattc gtaatagacg taatctgtcg cacttacgtt 1920
tagccaaatt aggtccgtga aacagacaca aacctatatt tatgtggcca cggacaaacg 1980
aaaactataa gctacttcgc attctgaggt cttgttgggc taataataga ctgcaatcac 2040
gttgctgggg tggtatcctt aactaacaat atggtaagta cggtgatagt gacattcaaa 2100
atagggtggt aacttagcat ggtctacttg gtggcagaag tggaagtggt agttatattc 2160
agctttatgg ttttacactg tatatttcac ttggcggtcg ccacaataaa gatttagaat 2220
ccactggcag aaagtcagcg catttttata gcagacaact tgcaaaggga gaggttcatg 2280
caacgtgtta tggtggatca agttatctta gtaagacata aacttgtata gacaataaca 2340
gtggcggaaa ttaaggttaa gataattgta actatagttc cgggagagaa ctatttaatt 2400
ccgacaactg ttatagccaa aatagatgaa atagagcgta taaaacctat tcttccaagc 2460
gtaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 2492
<210> 68
<211> 2277
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 68
gattggatta aaaagttgta gtaaaccaca acgaagttag gtagctggta aggttataga 60
tgcgttctgt cgttgtagtc ccaatgaaca tagtatggtt tcgcatagta actgacctaa 120
aagaccgcca catagtgaaa atacttaaaa cgcaagtttc ataggattaa gtggtagagg 180
ctatagaaaa tgatatcata actataacga atataacagc aaattaaaat gcactggaag 240
tggaaaattt cagcaagaga gtcgaagtcg tcatagatta gcatggacga aagaaaagtc 300
gcaaagatcg gaaatcaaga cgcaaaacaa aacggagaag ttcaaatcga actcgtagaa 360
catatcgctg gaacatatta aactcttggt atcgctcagt tacaaaagga gacacgtaga 420
cacgaaagaa actggaacaa cagacatatt tgtggataat ggcaattata gttaaaatag 480
tcgtaaatta gattatggtg caccggggtg taagtttcga actcggtgag gcaatagtag 540
tatagactaa caacaaggta gacattgcaa tgtattgcga gaagaacttc acgaagatat 600
agatacagta cagaatttct aggattaagt acagcagacg tatttacacc tgttatagga 660
tacttgttca cttaatccct gttatgacaa agtagtctca tagaattttt agaacgagaa 720
gatttgaatg gacgtaaagg aagaaggtca aaatggagaa cttaaaaggg gaaatctaga 780
acattgaacc caacattata caatgatata agaacgaaaa gacgaagaca ataaggtcca 840
tgggatttac ccaaatgagg acctaaatca ccgggaagaa gtaagtaaac ataacgatat 900
agttttagat tatcgagaag tcgaagaaga ccgggatagg taacagataa tcgacgtttg 960
ggaagacggt aacgtaagaa actgaggagg ttaaagaact aagaatcaac aacaagaaac 1020
tattgtccct attctactta ggtatctgct agtatgcgat atggaagtta aagaggaaac 1080
agtagtatgc actgtttgag aaaattagga tttaagaggt ggagaagtcg ttagtttgga 1140
agcatagata gttcaaatat ccacagaagg ctattaaaag atagaagaga gtcgagagat 1200
cgattttaaa gtctgagtcg aaatagtttg gtgcaagatt atccattcaa ttcttatcga 1260
aaacttacaa ggtcaacaag tagagatagc aatataacta aaagctatct attgaacata 1320
aatgcgcgac tacagcttgc gggttaacac ggtcgtcttc attatacgtt taatcgacgc 1380
cggcttattc atgcagatat ttaactcaat cttcgatagg atagaggacg tagtagactt 1440
ggatgtctgt catccagaca tgagacatat acttatatgg ataatggtag tgcagcaaag 1500
tcgtataatt taaacggtat gggacgaagc taacaacata gaggtggaca acgtatagca 1560
ggtaattgtt aaacttgttc tggaaataaa gaaagaaatc ttttggacta tgggcgtggc 1620
attagtatca agagtagtct tggtttgtat tatattggca gtgagcttat tcgtaataga 1680
cgtaatctgt cgcacttacg tttagccaaa ttaggtccgt gaaacagaca caaacctata 1740
tttatgtggc cacggacaaa cgaaaactat aagctacttc gcattctgag gtcttgttgg 1800
gctaataata gactgcaatc acgttgctgg ggtggtatcc ttaactaaca atatggtaag 1860
tacggtgata gtgacattca aaatagggtg gtaacttagc atggtctact tggtggcaga 1920
agtggaagtg gtagttatat tcagctttat ggttttacac tgtatatttc acttggcggt 1980
cgccacaata aagatttaga atccactggc agaaagtcag cgcattttta tagcagacaa 2040
cttgcaaagg gagaggttca tgcaacgtgt tatggtggat caagttatct tagtaagaca 2100
taaacttgta tagacaataa cagtggcgga aattaaggtt aagataattg taactatagt 2160
tccgggagag aactatttaa ttccgacaac tgttatagcc aaaatagatg aaatagagcg 2220
tataaaacct attcttccaa gcgtaataaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 2277
<210> 69
<211> 2528
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 69
gatgaaactt gagaaatcgc actggcttac atatacacga taaaagactt taatacaata 60
taagaagtcg ttattgaaga cggagatgta tgttaccgcc caattttaga gatacaaaat 120
gagactgaca tagcggttaa ctatattaga gcacgcctaa gcattgaagg tttagtcatc 180
ttcattagag tatactgtat tgacggctga atgcaaataa attgagacaa aaccgatttc 240
ttgaattagc acgaagtaag tataaaacta gtagagtgac accaagtata tagggggttt 300
atatcgcgtg gaatcgaaca acatatctat ttaattagtt taataacaaa ttaagtgact 360
tatcgcggaa gagagaacaa tagattggat taaaaagttg tagtaaacca caacgaagtt 420
aggtagctgg taaggttata gatgcgttct gtcgttgtag tcccaatgaa catagtatgg 480
tttcgcatag taactgacct aaaagaccgc cacatagtga aaatacttaa aacgcaagtt 540
tcataggatt aagtggtaga ggctatagaa aatgatatca taactataac gaatataaca 600
gcaaattaaa atgcactgga tgttagagca aattatataa actttcacat gctaaccaac 660
gtaatttgag aagaaatcat caagaattaa actaaaggaa tggtggataa tggcaattat 720
agttaaaata gtcgtaaatt agattatggt gcaccggggt gtaagtttcg aactcggtga 780
ggcaatagta gtatagacta acaacaaggt agacattgca atgtattgcg agaagaactt 840
cacgaagata tagatacagt acagaatttc taggattaag tacagcagac gtatttacac 900
ctgttatagg atacttgttc acttaatccc tgttatgaca aagtagtctc atagaatttt 960
tagaacgaga agatttgaat ggacgtaaag gaagaaggtc aaaatggaga acttaaaagg 1020
ggaaatctag aacattgaac ccaacattat acaatgatat aagaacgaaa agacgaagac 1080
aataaggtcc atgggattta cccaaatgag gacctaaatc accgggaaga agtaagtaaa 1140
cataacgata tagttttaga ttatcgagaa gtcgaagaag accgggatag gtaacagata 1200
atcgacgttt gggaagacgg taacgtaaga aactgaggag gttaaagaac taagaatcaa 1260
caacaagaaa ctattgtccc tattctactt aggtatctgc tagtatgcga tatggaagtt 1320
aaagaggaaa cagtagtatg cactgtttga gaaaattagg atttaagagg tggagaagtc 1380
gttagtttgg aagcatagat agttcaaata tccacagaag gctattaaaa gatagaagag 1440
agtcgagaga tcgattttaa agtctgagtc gaaatagttt ggtgcaagat tatccattca 1500
attcttatcg aaaacttaca aggtcaacaa gtagagatag caatataact aaaagctatc 1560
tattgaacat aaatgcgcga ctacagcttg cgggttaaca cggtcgtctt cattatacgt 1620
ttaatcgacg ccggcttatt catgcagata tttaactcaa tcttcgatag gatagaggac 1680
gtagtagact tggatgtctg tcatccagac atgagacata tacttatatg gataatggta 1740
gtgcagcaaa gtcgtataat ttaaacggta tgggacgaag ctaacaacat agaggtggac 1800
aacgtatagc aggtaattgt taaacttgtt ctggaaataa agaaagaaat cttttggact 1860
atgggcgtgg cattagtatc aagagtagtc ttggtttgta ttatattggc agtgagctta 1920
ttcgtaatag acgtaatctg tcgcacttac gtttagccaa attaggtccg tgaaacagac 1980
acaaacctat atttatgtgg ccacggacaa acgaaaacta taagctactt cgcattctga 2040
ggtcttgttg ggctaataat agactgcaat cacgttgctg gggtggtatc cttaactaac 2100
aatatggtaa gtacggtgat agtgacattc aaaatagggt ggtaacttag catggtctac 2160
ttggtggcag aagtggaagt ggtagttata ttcagcttta tggttttaca ctgtatattt 2220
cacttggcgg tcgccacaat aaagatttag aatccactgg cagaaagtca gcgcattttt 2280
atagcagaca acttgcaaag ggagaggttc atgcaacgtg ttatggtgga tcaagttatc 2340
ttagtaagac ataaacttgt atagacaata acagtggcgg aaattaaggt taagataatt 2400
gtaactatag ttccgggaga gaactattta attccgacaa ctgttatagc caaaatagat 2460
gaaatagagc gtataaaacc tattcttcca agcgtaataa aaaaaaaaaa aaaaaaaaaa 2520
aaaaaaaa 2528
<210> 70
<211> 458
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 70
ggctatagaa aatgatatca taactataac gaatataaca gcaaattaaa atgcactgga 60
taataaaaat taaactaata tttgtagtta gtggtgcaga tttgaacgaa cagtcaggcg 120
aaatggaagt aatagatgat tcatggacga taagtcatta agacatcgaa gactgttttg 180
ttgttatggc agaaacagac aaaatatcag gctacaaaaa tgtatcagag cattaacatg 240
aaaaatccta agagatcgac gaagttatcg actaaattgt tgtaatccaa gaggctgatt 300
gacgtttaga agtaagtggc aatttggttt aaaacaacga taataaaggt tgcgaagaaa 360
tataaaaagt agtcacataa cactgacatt attaaattta gatagacttt accgctaaaa 420
ctgtagttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa 458
<210> 71
<211> 2492
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 71
gtgagacgat gaaacttgag aaatcgcact ggcttacata tacacgataa aagactttaa 60
tacaatataa gaagtcgtta ttgaagacgg agatgtatgt taccgcccaa ttttagagat 120
acaaaatgag actgacatag cggttaacta tattagagca cgcctaagca ttgaaggttt 180
agtcatcttc attagagtat actgtattga cggctgaatg caaataaatt gagacaaaac 240
cgatttcttg aattagcacg aagtaagtat aaaactagta gagtgacacc aagtatatag 300
ggggtttata tcgcgtggaa tcgaacaaca tatctattta attagtttaa taacaaatta 360
agtgacttat cgcggaagag agaacaatag attggattaa aaagttgtag taaaccacaa 420
cgaagttagg tagctggtaa ggttatagat gcgttctgtc gttgtagtcc caatgaacat 480
agtatggttt cgcatagtaa ctgacctaaa agaccgccac atagtgaaaa tacttaaaac 540
gcaagtttca taggattaag tggtagaggc tatagaaaat gatatcataa ctataacgaa 600
tataacagca aattaaaatg cactggaagt ggaaaatttc agcaagagag tcgaagtcgt 660
catagattag catggataat ggcaattata gttaaaatag tcgtaaatta gattatggtg 720
caccggggtg taagtttcga actcggtgag gcaatagtag tatagactaa caacaaggta 780
gacattgcaa tgtattgcga gaagaacttc acgaagatat agatacagta cagaatttct 840
aggattaagt acagcagacg tatttacacc tgttatagga tacttgttca cttaatccct 900
gttatgacaa agtagtctca tagaattttt agaacgagaa gatttgaatg gacgtaaagg 960
aagaaggtca aaatggagaa cttaaaaggg gaaatctaga acattgaacc caacattata 1020
caatgatata agaacgaaaa gacgaagaca ataaggtcca tgggatttac ccaaatgagg 1080
acctaaatca ccgggaagaa gtaagtaaac ataacgatat agttttagat tatcgagaag 1140
tcgaagaaga ccgggatagg taacagataa tcgacgtttg ggaagacggt aacgtaagaa 1200
actgaggagg ttaaagaact aagaatcaac aacaagaaac tattgtccct attctactta 1260
ggtatctgct agtatgcgat atggaagtta aagaggaaac agtagtatgc actgtttgag 1320
aaaattagga tttaagaggt ggagaagtcg ttagtttgga agcatagata gttcaaatat 1380
ccacagaagg ctattaaaag atagaagaga gtcgagagat cgattttaaa gtctgagtcg 1440
aaatagtttg gtgcaagatt atccattcaa ttcttatcga aaacttacaa ggtcaacaag 1500
tagagatagc aatataacta aaagctatct attgaacata aatgcgcgac tacagcttgc 1560
gggttaacac ggtcgtcttc attatacgtt taatcgacgc cggcttattc atgcagatat 1620
ttaactcaat cttcgatagg atagaggacg tagtagactt ggatgtctgt catccagaca 1680
tgagacatat acttatatgg ataatggtag tgcagcaaag tcgtataatt taaacggtat 1740
gggacgaagc taacaacata gaggtggaca acgtatagca ggtaattgtt aaacttgttc 1800
tggaaataaa gaaagaaatc ttttggacta tgggcgtggc attagtatca agagtagtct 1860
tggtttgtat tatattggca gtgagcttat tcgtaataga cgtaatctgt cgcacttacg 1920
tttagccaaa ttaggtccgt gaaacagaca caaacctata tttatgtggc cacggacaaa 1980
cgaaaactat aagctacttc gcattctgag gtcttgttgg gctaataata gactgcaatc 2040
acgttgctgg ggtggtatcc ttaactaaca atatggtaag tacggtgata gtgacattca 2100
aaatagggtg gtaacttagc atggtctact tggtggcaga agtggaagtg gtagttatat 2160
tcagctttat ggttttacac tgtatatttc acttggcggt cgccacaata aagatttaga 2220
atccactggc agaaagtcag cgcattttta tagcagacaa cttgcaaagg gagaggttca 2280
tgcaacgtgt tatggtggat caagttatct tagtaagaca taaacttgta tagacaataa 2340
cagtggcgga aattaaggtt aagataattg taactatagt tccgggagag aactatttaa 2400
ttccgacaac tgttatagcc aaaatagatg aaatagagcg tataaaacct attcttccaa 2460
gcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 2492
<210> 72
<211> 979
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 72
gtgccaaatt agcgaacaat ttgagaagag cagtgagacg atgaaacttg agaaatcgca 60
ctggcttaca tatacacgat aaaagacttt aatacaatat aagaagtcgt tattgaagac 120
ggagatgtat gttaccgccc aattttagag atacaaaatg agactgacat agcggttaac 180
tatattagag cacgcctaag cattgaaggt ttagtcatct tcattagagt atactgtatt 240
gacggctgaa tgcaaataaa ttgagacaaa accgatttct tgaattagca cgaagtaagt 300
ataaaactag tagagtgaca ccaagtatat agggggttta tatcgcgtgg aatcgaacaa 360
catatctatt taattagttt aataacaaat taagtgactt atcgcggaag agagaacaat 420
agattggatt aaaaagttgt agtaaaccac aacgaagtta ggtagctggt aaggttatag 480
atgcgttctg tcgttgtagt cccaatgaac atagtatggt ttcgcatagt aactgaccta 540
aaagaccgcc acatagtgaa aatacttaaa acgcaagttt cataggatta agtggtagag 600
gctatagaaa atgatatcat aactataacg aatataacag caaattaaaa tgcactggat 660
aataaaaatt aaactaatat ttgtagttag tggtgcagat ttgaacgaac agtcaggcga 720
aatggaagta atagatgatt catggacgat aagtcattaa gacatcgaag actgttttgg 780
atgtagacat atttgtagaa cattaaagaa agatatgagt tctttatttc aaaaacatag 840
atggttggct ggttagcaac gtcaaagccc acagtatcta atgttgttat ggcagaaaca 900
gacaaaatat caggctacaa aaatgtatca gagcattaac atgaaaaata aaaaaaaaaa 960
aaaaaaaaaa aaaaaaaaa 979
<210> 73
<211> 2356
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 73
gcactggctt acatatacac gataaaagac tttaatacaa tataagaagt cgttattgaa 60
gacggagatg tatgttaccg cccaatttta gagatacaaa atgagactga catagcggtt 120
aactatatta gagcacgcct aagcattgaa ggtttagtca tcttcattag agtatactgt 180
attgacggct gaatgcaaat aaattgagac aaaaccgatt tcttgaatta gcacgaagta 240
agtataaaac tagtagagtg acaccaagta tatagggggt ttatatcgcg tggataataa 300
aaattaaact aatatttgta gttagtggtg cagatttgaa cgaacagtca ggcgaaatgg 360
aagtaataga tgattcatgg acgataagtc attaagacat cgaagactgt tttggaagtg 420
gaaaatttca gcaagagagt cgaagtcgtc atagattagc atggatttcg aagaacgcga 480
agaactaaac gaacaagtta tgaacgaaat tagagtccta ataacctgtt tagtgaattg 540
accagtagtc atataacaaa aacaagaagg ttaggcaaag ctataagcaa atagcattga 600
aatagaaatg gacgagaaga aggctttaaa atggtagtcg tatgcgaacg ctaaggaaga 660
gaaattctag tagaactcgt agttacatac ttggacgaaa gaaaagtcgc aaagatcgga 720
aatcaagacg caaaacaaaa cggagaagtt caaatcgaac tcgtagaaca tatcgctgga 780
acatattaaa ctcttggtat cgctcagtta caaaaggaga cacgtagaca cgaaagaaac 840
tggaacaaca gacatatttg tggatgttag agcaaattat ataaactttc acatgctaac 900
caacgtaatt tgagaagaaa tcatcaagaa ttaaactaaa ggaatggtgg ataatggcaa 960
ttatagttaa aatagtcgta aattagatta tggtgcaccg gggtgtaagt ttcgaactcg 1020
gtgaggcaat agtagtatag actaacaaca aggtagacat tgcaatgtat tgcgagaaga 1080
acttcacgaa gatatagata cagtacagaa tttctaggat taagtacagc agacgtattt 1140
acacctgtta taggatactt gttcacttaa tccctgttat gacaaagtag tctcatagaa 1200
tttttagaac gagaagattt gaatggacgt aaaggaagaa ggtcaaaatg gagaacttaa 1260
aaggggaaat ctagaacatt gaacccaaca ttatacaatg atataagaac gaaaagacga 1320
agacaataag gtccatggga tttacccaaa tgaggaccta aatcaccggg aagaagtaag 1380
taaacataac gatatagttt tagattatcg agaagtcgaa gaagaccggg ataggtaaca 1440
gataatcgac gtttgggaag acggtaacgt aagaaactga ggaggttaaa gaactaagaa 1500
tcaacaacaa gaaactattg tccctattct acttaggtat ctgctagtat gcgatatgga 1560
agttaaagag gaaacagtag tatgcactgt ttgagaaaat taggatttaa gaggtggaga 1620
agtcgttagt ttggaagcat agatagttca aatatccaca gaaggctatt aaaagataga 1680
agagagtcga gagatcgatt ttaaagtctg agtcgaaata gtttggtgca agattatcca 1740
ttcaattctt atcgaaaact tacaaggtca acaagtagag atagcaatat aactaaaagc 1800
tatctattga acataaatgc gcgactacag cttgcgggtt aacacggtcg tcttcattat 1860
acgtttaatc gacgccggct tattcatgca gatatttaac tcaatcttcg ataggataga 1920
ggacgtagta gacttggatg tctgtcatcc agacatgaga catatactta tatggataat 1980
ggtagtgcag caaagtcgta taatttaaac ggtatgggac gaagctaaca acatagaggt 2040
ggacaacgta tagcaggtaa ttgttaaact tgttctggaa ataaagaaag aaatcttttg 2100
gactatgggc gtggcattag tatcaagagt agtcttggtt tgtattatat tggcagtgag 2160
cttattcgta atagacgtaa tctgtcgcac ttacgtttag ccaaattagg tccgtgaaac 2220
agacacaaac ctatatttat gtggccacgg acaaacgaaa actataagct acttcgcatt 2280
ctgaggtctt gttgggctaa taatagactg caatcacgtt gctgggaaaa aaaaaaaaaa 2340
aaaaaaaaaa aaaaaa 2356
<210> 74
<211> 919
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 74
gtgccaaatt agcgaacaat ttgagaagag cagtgagacg atgaaacttg agaaatcgca 60
ctggcttaca tatacacgat aaaagacttt aatacaatat aagaagtcgt tattgaagac 120
ggagatgtat gttaccgccc aattttagag atacaaaatg agactgacat agcggttaac 180
tatattagag cacgcctaag cattgaaggt ttagtcatct tcattagagt atactgtatt 240
gacggctgaa tgcaaataaa ttgagacaaa accgatttct tgaattagca cgaagtaagt 300
ataaaactag tagagtgaca ccaagtatat agggggttta tatcgcgtgt ttaataacaa 360
attaagtgac ttatcgcgga agagagaaca atagattgga ttaaaaagtt gtagtaaacc 420
acaacgaagt taggtagctg gtaaggttat agatgcgttc tgtcgttgta gtcccaatga 480
acatagtatg gtttcgcata gtaactgacc taaaagaccg ccacatagtg aaaatactta 540
aaacgcaagt ttcataggat taagtggtag aggctataga aaatgatatc ataactataa 600
cgaatataac agcaaattaa aatgataata aaaattaaac taatatttgt agttagtgtc 660
aggcgaaatg gaagtaatag atgattcatg gacgataagt cattaagaca tcgaagactg 720
ttttggatgt agacatattt gtagaacatt aaagaaagat atgagttctt tatttcaaaa 780
acatagatgg ttggctggtt agcaacgtca aagcccacag tatctaatgt tgttatggca 840
gaaacagaca aaatatcagg ctacaaaaat gtatcagagc attaacatga aaaaaaaaaa 900
aaaaaaaaaa aaaaaaaaa 919
<210> 75
<211> 1561
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 75
gcttgtccgc gagtgtcaac cgggttttac aaaggagaac ttccaacatc agtgtatggg 60
atgtttcaaa cacccccaga gacggagaca atagtgtggt cacgtacatt taggaagata 120
aaaataacaa caacagaagg tgtgaggcgc aaggtacatg ctcttacccc actctcagca 180
cgtagggagc ggagtgtgga agaccaacaa gcccgtcgcc tctaccaaat acagctatcc 240
tgaggtgcca ggttagaata ggccctacca catctaagcc ttgaaacggt ctgttcctcg 300
tgtcaagttc tttgtccgct tataccgcca tctctcgttg tggtacaaga gttggttact 360
ctcagtccca ttcccaacac atcactgaga agtatagagc ctagtggtca ttagaaggtc 420
aacatggagt aggtgtttag gtgtgtcgga gggcagaaac caacgaaaga aaggaaacga 480
tcaacactta tatagtgtcc tgtcgggccc aaatcctaag agaccttagg tttaccacat 540
tagtactaaa cagcctgttg tataccgtga gcccccactt cgatctgtaa atggtaatcc 600
cttgtaaaac ctcatctcca aaaacagtat acgcaggtac agctgatgtg atcctctcta 660
ctagtcttct ctgaggaacc atgagatgga tagtggggga cctgagtcat actagggtaa 720
cttcttatat ggtgacatca ctcctaccgt agagggggga cggtagtctg tgggaaatct 780
accctagtga agaaaggtaa gagaatgtct gaacattacc tgtagacgaa ggtactctca 840
gaacaactac tctcacatac ggaaaggttt gggtccttgg tcaaaggact ttactgactc 900
tgcagacgat gaatatctga accaacacta ctatcaaaga tgttcgacta gacctctcgt 960
ggtagggcct ggaagtcaaa agacttctct atgggtacta ggtaggtagt tagagtacgg 1020
tccctggggt gtctcagagt cgaacgttcg ggggaagttc ctaaacatgt taggatgtta 1080
tgataacaag tccaaacgtg gacgtcgtcg ctgtcacctc tcggaacact agctgaggtg 1140
gcttaaaaac attccgtaac tgagtggtca ccgggggtga aacatgctga gggttctacc 1200
ttaacgggaa ggtgaaactc tccaatgtct ttgaaaggac tagttgagat aacccaaacc 1260
gaatccggag gaagaggaga acttggaaaa cgttgtacga cgtcattaat aacgattccg 1320
ttcttcccgt tcgtgtctat aaggatattc tttcattgcg aaggtaagcc cttttgggtc 1380
tagatacgga ctatactcaa aaacccacag accttccact tggagttgtt ttaggagacg 1440
gagtagtaga gaaaacttgt ggcaccttcc cagtcggttc cctacagact ctccttagta 1500
gctcctaaga tcgtcgagtt acacgacgac attgttccga ctgacgtaga ggcattactt 1560
t 1561
<210> 76
<211> 1300
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 76
gtacaagagt tggttactct cagtcccatt cccaacacat cactgagaag tatagagcct 60
agtggtcatt agaaggtcaa catggagtag gtgtttaggt gtgtcggagg gcagaaacca 120
acgaaagaaa ggaaacgatc aacacttata tagtgtcctg tcgggcccaa atcctaagag 180
accttaggtt taccacatta gtactaaaca gcctgttgta taccgtgagc ccccacttcg 240
atctgtaaat ggtaatccct tgtaaaacct catctccaaa aacagtatac gcaggtacag 300
ctgatgtgat cctctctact agtcttctct gaggaaccat gagatggata gtgggggacc 360
tgagtcatac tagggtaact tcttatatgg tgacatcact cctaccgtag aggggggacg 420
gtagtctgtg ggaaatctac cctagtgaag aaaggtaaga gaatgtctga acattacctg 480
tagacgaagg tactctcaga acaactactc tcacatacgg aaaggtttgg gtccttggtc 540
aaaggacttt actgactctg cagacgatga atatctgaac caacactact atcaaagatg 600
tcgtaggttt gtgagaaggg agaagaagtg gttgagaagt tggtgttcca caagttaaag 660
tagacatacc tttagtacct gtaaaggttc gactagacct ctcgtggtag ggcctggaag 720
tcaaaagact tctctatggg tactaggtag gtagttagag tacggtccct ggggtgtctc 780
agagtcgaac gttcggggga agttcctaaa catgttagga tgttatgata acaagtccaa 840
acgtggacgt cgtcgctgtc acctctcgga acactagctg aggtggctta aaaacattcc 900
gtaactgagt ggtcaccggg ggtgaaacat gctgagggtt ctaccttaac gggaaggtga 960
aactctccaa tgtctttgaa aggactagtt gagataaccc aaaccgaatc cggaggaaga 1020
ggagaacttg gaaaacgttg tacgacgtca ttaataacga ttccgttctt cccgttcgtg 1080
tctataagga tattctttca ttgcgaaggt aagccctttt gggtctagat acggactata 1140
ctcaaaaacc cacagacctt ccacttggag ttgttttagg agacggagta gtagagaaaa 1200
cttgtggcac cttcccagtc ggttccctac agactctcct tagtagctcc taagatcgtc 1260
gagttacacg acgacattgt tccgactgac gtagaggcat 1300
<210> 77
<211> 1363
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 77
gtgaggcttg tccgcgagtg tcaaccgggt tttacaaagg agaacttcca acatcagtgt 60
atgggatgtt tcaaacaccc ccagagacgg agacaatagt gtggtcacgt acatttagga 120
agataaaaat aacaacaaca gaaggtacaa gagttggtta ctctcagtcc cattcccaac 180
acatcactga gaagtataga gcctagtggt cattagaagg tcaacatgga gtaggtgttt 240
aggtgtgtcg gagggcagaa accaacgaaa gaaaggaaac gatcaacact tatatagtgt 300
cctgtcgggc ccaaatccta agagacctta ggtttaccac attagtacta aacagcctgt 360
tgtataccgt gagcccccac ttcgatctgt aaatggtaat cccttgtaaa acctcatctc 420
caaaaacagt atacgcaggt acagctgatg tgatcctctc tactagtctt ctctgaggaa 480
ccatgagatg gatagtgggg gacctgagtc atactagggt aacttcttat atggtgacat 540
cactcctacc gtagaggggg gacggtagtc tgtgggaaat ctaccctagt gaagaaaggt 600
aagagaatgt ctgaacatta cctgtagacg aaggtactct cagaacaact actctcacat 660
acggaaaggt ttgggtcctt ggtcaaagga ctttactgac tctgcagacg atgaatatct 720
gaaccaacac tactatcaaa gatgttcgac tagacctctc gtggtagggc ctggaagtca 780
aaagacttct ctatgggtac taggtaggta gttagagtac ggtccctggg gtgtctcaga 840
gtcgaacgtt cgggggaagt tcctaaacat gttaggatgt tatgataaca agtccaaacg 900
tggacgtcgt cgctgtcacc tctcggaaca ctagctgagg tggcttaaaa acattccgta 960
actgagtggt caccgggggt gaaacatgct gagggttcta ccttaacggg aaggtgaaac 1020
tctccaatgt ctttgaaagg actagttgag ataacccaaa ccgaatccgg aggaagagga 1080
gaacttggaa aacgttgtac gacgtcatta ataacgattc cgttcttccc gttcgtgtct 1140
ataaggatat tctttcattg cgaaggtaag cccttttggg tctagatacg gactatactc 1200
aaaaacccac agaccttcca cttggagttg ttttaggaga cggagtagta gagaaaactt 1260
gtggcacctt cccagtcggt tccctacaga ctctccttag tagctcctaa gatcgtcgag 1320
ttacacgacg acattgttcc gactgacgta gaggcattac ttt 1363
<210> 78
<211> 1399
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 78
gttttacaaa ggagaacttc caacatcagt gtatgggatg tttcaaacac ccccagagac 60
ggagacaata gtgtggtcac gtacatttag gaagataaaa ataacaacaa cagaagcctt 120
gaaacggtct gttcctcgtg tcaagttctt tgtccgctta taccgccatc tctcgttgtg 180
gtacaagagt tggttactct cagtcccatt cccaacacat cactgagaag tatagagcct 240
agtggtcatt agaaggtcaa catggagtag gtgtttaggt gtgtcggagg gcagaaacca 300
acgaaagaaa ggaaacgatc aacacttata tagtgtcctg tcgggcccaa atcctaagag 360
accttaggtt taccacatta gtactaaaca gcctgttgta taccgtgagc ccccacttcg 420
atctgtaaat ggtaatccct tgtaaaacct catctccaaa aacagtatac gcaggtacag 480
ctgatgtgat cctctctact agtcttctct gaggaaccat gagatggata gtgggggacc 540
tgagtcatac tagggtaact tcttatatgg tgacatcact cctaccgtag aggggggacg 600
gtagtctgtg ggaaatctac cctagtgaag aaaggtaaga gaatgtctga acattacctg 660
tagacgaagg tactctcaga acaactactc tcacatacgg aaaggtttgg gtccttggtc 720
aaaggacttt actgactctg cagacgatga atatctgaac caacactact atcaaagatg 780
ttcgactaga cctctcgtgg tagggcctgg aagtcaaaag acttctctat gggtactagg 840
taggtagtta gagtacggtc cctggggtgt ctcagagtcg aacgttcggg ggaagttcct 900
aaacatgtta ggatgttatg ataacaagtc caaacgtgga cgtcgtcgct gtcacctctc 960
ggaacactag ctgaggtggc ttaaaaacat tccgtaactg agtggtcacc gggggtgaaa 1020
catgctgagg gttctacctt aacgggaagg tgaaactctc caatgtcttt gaaaggacta 1080
gttgagataa cccaaaccga atccggagga agaggagaac ttggaaaacg ttgtacgacg 1140
tcattaataa cgattccgtt cttcccgttc gtgtctataa ggatattctt tcattgcgaa 1200
ggtaagccct tttgggtcta gatacggact atactcaaaa acccacagac cttccacttg 1260
gagttgtttt aggagacgga gtagtagaga aaacttgtgg caccttccca gtcggttccc 1320
tacagactct ccttagtagc tcctaagatc gtcgagttac acgacgacat tgttccgact 1380
gacgtagagg cattacttt 1399
<210> 79
<211> 670
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 79
gcgcaaggta catgctctta ccccactctc agcacgtagg gagcggagta caagagttgg 60
ttactctcag tcccattccc aacacatcac tgagaagtat agagcctagt ggtcattaga 120
aggtcaacat ggagtaggtg tttaggtgtg tcggagggca gaaaccaacg aaagaaagga 180
aacgatcaac acttatatag tgtcctgtcg ggcccaaatc ctaagagacc ttaggtttac 240
cacattagta ctaaacagcc tgttgtatac cgtgagcccc cacttcgatc tgtaaatggt 300
aatcccttgt aaaacctcat ctccaaaaac agtatacgca ggtacagctg atgtgatcct 360
ctctactagt cttctctgag gaaccatgag atggatagtg ggggacctga gtcatactag 420
ggtaacttct tatatggtga catcactcct accgtagagg ggggacggta gtctgtggga 480
aatctaccct agtgaagaaa ggtaagagaa tgtctgaaca ttacctgtag acgaaggtac 540
tctcagaaca actactctca catacggaaa ggtttgggtc cttggtcaaa ggactttact 600
gactctgcag acgatgaata tctgaaccaa cactactatc aaagatgttc gactagacct 660
ctcgtggtag 670
<210> 80
<211> 973
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 80
gcttgtccgc gagtgtcaac cgggttttac aaaggagaac ttccaacatc agtgtatggg 60
atgtttcaaa cacccccaga gacggagaca atagtgtggt cacgtacatt taggaagata 120
aaaataacaa caacagaagg tgtgaggcgc aaggtacatg ctcttacccc actctcagca 180
cgtagggagc ggagtgtgga agaccaacaa gcccgtcgcc tctaccaaat acagtgttta 240
ggtgtgtcgg agggcagaaa ccaacgaaag aaaggaaacg atcaacactt atatagtgtc 300
ctgtcgggcc caaatcctaa gagaccttag gtttaccaca ttagtactaa acagcctgtt 360
gtataccgtg agcccccact tcgatctgta aatggtaatc ccttgtaaaa cctcatctcc 420
aaaaacagta tacgcaggta cagctgatgt gatcctctct actagtcttc tctgaggaac 480
catgagatgt tatgataaca agtccaaacg tggacgtcgt cgctgtcacc tctcggaaca 540
ctagctgagg tggcttaaaa acattccgta actgagtggt caccgggggt gaaacatgct 600
gagggttcta ccttaacggg aaggtgaaac tctccaatgt ctttgaaagg actagttgag 660
ataacccaaa ccgaatccgg aggaagagga gaacttggaa aacgttgtac gacgtcatta 720
ataacgattc cgttcttccc gttcgtgtct ataaggatat tctttcattg cgaaggtaag 780
cccttttggg tctagatacg gactatactc aaaaacccac agaccttcca cttggagttg 840
ttttaggaga cggagtagta gagaaaactt gtggcacctt cccagtcggt tccctacaga 900
ctctccttag tagctcctaa gatcgtcgag ttacacgacg acattgttcc gactgacgta 960
gaggcattac ttt 973
<210> 81
<211> 744
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 81
gtgaggcatc tataccgcca cgccctatgt ctttctcacg tataggtgtg ctctcagctg 60
ccgttccggc gctgcttcac ccctttccgc ttatcgcgga tggtaaagtc aaagtttact 120
cagcggtcgc tgttgacctc aggttctcta tcaaaaattt gctggctaaa acggtcggag 180
cttctgctcc actctttcca gcaatccttc tgccagtcgc cttcaaactt gcaatctgtg 240
gattcgtcga acgtccgggt agtatagtta tctgcatcgt ggtcaccagt atcacagact 300
acaaaatctc aatcctccat tcccccgtca ggtctatcta aaattcaatc gctgtgtttg 360
cggggtaaat aataggacaa gtccgtataa tctacccaat cgcattcatt ccagtcagag 420
ggtaccaccg aatttcatca acaacattaa taattccata ggaactacat tcttaaatcc 480
ttggaactcc aaactcctac cttatcacgg ttctatccgt cgtcttaggg tcggtctcct 540
cgtagcatgg cctcgttctc ctcgccgtaa ttgcggtcga aagtacttca gttatttatg 600
gtgaggcttg tccgcgagtg tcaaccgggt tttacaaagg agaacttcca acatcagtgt 660
atgggatgtt tcaaacaccc ccagagacgg agacaatagt gtggtcacgt acatttagga 720
agataaaaat aacaacaaca gaag 744
<210> 82
<211> 702
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 82
gtcttccaca ctccgctccc tacgtgctga gagtggggta agagcatgta ccttgcgcct 60
cacaccttct gttgttgtta tttttatctt cctaaatgta cgtgaccaca ctattgtctc 120
cgtctctggg ggtgtttgaa acatcccata cactgatgtt ggaagttctc ctttgtaaaa 180
cccggttgac actcgcggac aagcctcact actttcgacc gcaattacgg cgaggagaac 240
gaggccatgc tacgaggaga ccgaccctaa gacgacggat agaaccgtga taaggtagga 300
gtttggagtt ccaaggattt aagaatgtag ttcctatgga attattaatg ttgttgatga 360
aattcggtgg taccctctga ctggaatgaa tgcgattggg tagattatac ggacttgtcc 420
tattatttac cccgcaaaca cagcgattga attttagata gacctgacgg gggaatggag 480
gattgagatt ttgtagtctc acagattgca agtttgaagg cgactggcag aaggattgct 540
ggaaagagtg gagcagaagc tccgaccgtt ttagccagca aatttttgat agagaacctg 600
aggtcaacag cgaccgctga gtaaactttg actttaccat ccgcgataag cggaaagggg 660
tgaagcagcg ccggaacggc agctgagagc acacctatac gt 702
<210> 83
<211> 464
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 83
gggtgtttga aacatcccat acactgatgt tggaagttct cctttgtaaa acccggttga 60
cactcgcgga caagcctcac cataaataac tgaagtactt tcgaccgcaa ttacggcgag 120
gagaacgagg ccatgctacg aggagaccga ccctaagacg acggatagaa ccgtgataag 180
gtaggagttt ggagttccaa ggatttaaga atgtagttcc tatggaatta ttaatgttgt 240
tgatgaaatt cggtgaagga ttgctggaaa gagtggagca gaagctccga ccgttttagc 300
cagcaaattt ttgatagaga acctgaggtc aacagcgacc gctgagtaaa ctttgacttt 360
accatccgcg ataagcggaa aggggtgaag cagcgccgga acggcagctg agagcacacc 420
tatacgtgag aaagacatag ggcgtggcgg tatagatgcc tcac 464
<210> 84
<211> 2051
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 84
gtgtatttat ccgctacgtg gtggatgaac atggatgcga acgacatttc gaaatatacg 60
caatgatatc caaccctacc gaaacagcaa taattgtaga aggtagcata tcatgccgag 120
agtttactac gttgtagcga gtttagttga aatagtttgt gatgtgtaaa ctaaaacata 180
ccaaatggta aaacttgtca cccccattta cattgcgaca gacacagtta tggagtggat 240
ggaagtgtgt tcgactgtca agacccttct ataatagtcg aaccagtacg gtaagtgggc 300
aacatgccca tataagtcga agcatttcaa atggttcatc cagtagacga cgatgtccta 360
gacagtcatg tctcttcccc atttgaagtc atgtagtggt tgtctacttt ttcattgaag 420
acgtccacct caacgctatg aacgttagtt gagacaatgt taaagcaaac gacaacgtca 480
ttgtgatcta catacacagt ggatggttag cgtaaacatg gtggaacgta ctttgactgc 540
gctgcaagaa atggttgggt cgatcgtaat gctagtcgtt acatcggaac aagccaaaac 600
aaatcattcg ctggatttag acctactgca cgacgacgtc gacacaagac attcttgaaa 660
ggaattcaat gcagaaactc ctatgcacgt cgaactagtc tcttgctcag cgctagtcca 720
tgaaaatgtc ctagctttga acgtttatca aatgcaagtt gtgggagtta gtcatgtgag 780
agttgtgcaa gaaagtgtta acgttctagc cgtgctcagt aacaattacc attcggcggt 840
aacaaacgta agttgtcact gcactcatga gcatgaagtt agaccagtag ttgggtcaga 900
aattagacgt ggtttagtct ggttaccgtg gaaagaatag ctgaactcaa agaagccgac 960
aaagataaac aaagaagaaa cggttaatac gattgaggag aaatattcaa tccaacggca 1020
actattaacg tttcaactag aatctacgtt tcatacgcgg attccacatc cgttcttgca 1080
attaaagaaa cgatgtagaa aacgctttgg ttggcgacaa cttgggcggc aaaataatta 1140
tggtaggtaa ttgaagtagc gttaaaacgc aaaaagaagg aagcacggat cactgcaaaa 1200
aggactactc aataatggtt tctaaagtca ttatgctggt gctccctatg gcggtggtca 1260
gtactgtaac taaagatgga ttacggcact tgtagagcac gtatcagacc cagctttgaa 1320
agaaggctga gttcggttcg ggtttcacgt aggcctagaa cgaggtatag aagtggttaa 1380
caaagatttg gttaccatgt aagaagcggt agacgccatg gcctagtagg aagaatgctt 1440
gttcacggag ccgacgaagt tagacgagtg gcagaagaaa gagcattatc ttggtactcg 1500
gactgaatgc gtactacggt cgtccaagtt gcaagaggta ttagagtcat tcgaatagct 1560
gtgggagtgg tatttatagc ataataagtg taaaaaacat tcccaacagc atatgtgtag 1620
ccaagaagcg ttgtgctcgc gactaaaagt caggtagcag caggcattaa cccagtgata 1680
gaacatcaaa gtcaaataag tatggtttag cattactgcg tatcttgcga ttgcgtgctg 1740
gtggtcaaca gtgcaaacct agtggcttcg cactcaaatg tagacaagca ttaaccaact 1800
acttctaacg tatgttcagg aagaatggct attctcgtca ggtgaatgcg taatcgaatg 1860
agtagtatgg tcgaacgtcc cgctatagtc tgacacgatt caggcaaagt tggagtgcaa 1920
agccatgatt tggtcgatgc ggcaaatgtt gcttaggact attctatggt cttgcgtaat 1980
tgtgaagatt tgccagttat ctaaggagac gtggtgattc gctctatagc tgtatctaat 2040
ctgccagatt g 2051
<210> 85
<211> 1971
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 85
gttggtgtat ttatccgcta cgtggtggat gaacatggat gcgaacgaca tttcgaaata 60
tacgcaatga tatccaaccc taccgaaaca gcaataattg tagaaggtag catatcatgc 120
cgagagttta ctacgttgta gcgagtttag ttgaaatagt ttgtgatgtg taaactaaaa 180
cataccaaat ggtaaaactt gtcaccccca tttacattgc gacagacaca gttatggagt 240
ggatggaagt gtgttcgact gtcaagaccc ttctataata gtcgaaccag tacggtaagt 300
gggcaacatg cccatataag tcgaagcatt tcaaatggtt catccagtag acgacgatgt 360
cctagacagt catgtctctt ccccatttga agtcatgtag tggttgtcta ctttttcatt 420
gaagacgtcc acctcaacgc tatgaacgtt agttgagaca atgttaaagc aaacgacaac 480
gtcattgtga tctacataca cagtggatgg ttagcgtaaa catggtggaa cgtactttga 540
ctgcgctgca agaaatggtt gggtcgatcg taatgctagt cgttacatcg gaacaagcca 600
aaacaaatca ttcgctggat ttagacctac tgcacgacga cgtcgacaca agacattctt 660
gaaagcgcta gtccatgaaa atgtcctagc tttgaacgtt tatcaaatgc aagttgtggg 720
agttagtcat gtgagagttg tgcaagaaag tgttaacgtt ctagccgtgc tcagtaacaa 780
ttaccattcg gcggtaacaa acgtaagttg tcactgcact catgagcatg aagttagacc 840
agtagttggg tcagaaatta gacgtggttt agtctggtta ccgtggaaag aatagctgaa 900
ctcaaagaag ccgacaaaga taaacaaaga agaaacggtt aatacgattg aggagaaata 960
ttcaatccaa cggcaactat taacgtttca actagaatct acgtttcata cgcggattcc 1020
acatccgttc ttgcaattaa agaaacgatg tagaaaacgc tttggttggc gacaacttgg 1080
gcggcaaaat aattatggta ggtaattgaa gtagcgttaa aacgcaaaaa gaaggaagca 1140
cggatcactg caaaaaggac tactcaataa tggtttctaa agtcattatg ctggtgctcc 1200
ctatggcggt ggtcagtact gtaactaaag atggattacg gcacttgtag agcacgtatc 1260
agacccagct ttgaaagaag gctgagttcg gttcgggttt cacgtaggcc tagaacgagg 1320
tatagaagtg gttaacaaag atttggttac catgtaagaa gcggtagacg ccatggccta 1380
gtaggaagaa tgcttgttca cggagccgac gaagttagac gagtggcaga agaaagagca 1440
ttatcttggt actcggactg aatgcgtact acggtcgtcc aagttgcaag aggtattaga 1500
gtcattcgaa tagctgtggg agtggtattt atagcataat aagtgtaaaa aacattccca 1560
acagcatatg tgtagccaag aagcgttgtg ctcgcgacta aaagtcaggt agcagcaggc 1620
attaacccag tgatagaaca tcaaagtcaa ataagtatgg tttagcatta ctgcgtatct 1680
tgcgattgcg tgctggtggt caacagtgca aacctagtgg cttcgcactc aaatgtagac 1740
aagcattaac caactacttc taacgtatgt tcaggaagaa tggctattct cgtcaggtga 1800
atgcgtaatc gaatgagtag tatggtcgaa cgtcccgcta tagtctgaca cgattcaggc 1860
aaagttggag tgcaaagcca tgatttggtc gatgcggcaa atgttgctta ggactattct 1920
atggtcttgc gtaattgtga agatttgcca gttatctaag gagacgtggt g 1971
<210> 86
<211> 686
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 86
gctacgtggt ggatgaacat ggatgcgaac gacatttcga aatatacgca atgatatcca 60
accctaccga aacagcaata attgtagaag gtagcatatc atgccgagtc atcgacatgc 120
ctttatcgac acacgacgtg attggagttt actacgttgt agcgagttta gttgaaatag 180
tttgtgatgt gtaaactaaa acataccaaa tggtaaaact tgtcaccccc atttacattg 240
cgacagacac agttatggag tggatggaag tgtgttcgac tgtcaagacc cttctataat 300
agtcgaacca gtacggtaag tgggcaacat gcccatataa gtcgaagcat ttcaaatggt 360
tcatccagta gacgacgatg tcctagacag tcatgtctct tccccatttg aagtcatgta 420
gtggttgtct actttttcat tgaagacgtc cacctcaacg ctatgaacgt tagttgagac 480
aatgttaaag caaacgacaa cgtcattgtg atctacatac acagtggatg gttagcgtaa 540
acatggtgga acgtactttg actgcgctgc aagaaatggt tgggtcgatc gtaatgctag 600
tcgttacatc ggaacaagcc aaaacaaatc attcgctgga tttagaccta ctgcacgacg 660
acgtcgacac aagacattct tgaaag 686
<210> 87
<211> 740
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 87
gtaaaacttg tcacccccat ttacattgcg acagacacag ttatggagtg gatggaagtg 60
tgttcgactg tcaagaccct tctataatag tcgaaccagt acggtaagtg ggcaacatgc 120
ccatataagt cgaagcattt caaatggttc atccagtaga cgacgatgtc ctagacagtc 180
atgtctgtca catctatcac gcctcctacg ttgtgccata acgaagaata atagtgataa 240
gagacatcga agctgtcgta gtcgttcgct aaattgctta caatttagtg ctctaagtga 300
acaatgtttc atcttgagaa gcaaacgaag tagaagttga cgacgcattc gaagacgtgg 360
acaatgtgac acgagtatcg aaacatgatc caacgaacat cgaagaagtt actactgaac 420
tacgggtcag cttccccatt tgaagtcatg tagtggttgt ctactttttc attgaagacg 480
tccacctcaa cgctatgaac gttagttgag acaatgttaa agcaaacgac aacgtcattg 540
tgatctacat acacagtgga tggttagcgt aaacatggtg gaacgtactt tgactgcgct 600
gcaagaaatg gttgggtcga tcgtaatgct agtcgttaca tcggaacaag ccaaaacaaa 660
tcattcgctg gatttagacc tactgcacga cgacgtcgac acaagacatt cttgaaaggt 720
aattgacgtg gacgtttcag 740
<210> 88
<211> 523
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 88
gccgcatcga ccaaatcatg gctttgcact ccaactttgc ctgaatcgtg tcagactata 60
gcgggacgtt cgaccatact actcattcga ttacgcattc acctgacgag aatagccatt 120
cttcctgaac atacgttaga agtagttggt taatgcttgt ctacatttga gtgcgaagcc 180
actaggtttg cactgttgac caccagcacg caatcgcaag atacgcagta atgctaaacc 240
atacttattt gactttgatg ttctatcact gggttaatgc ctgctgctac ctgactttta 300
gtcgcgagca caacgcttct tggctacaca tatgctgttg ggaatgtttt ttacacttat 360
tatgctataa ataccactcc cacagctatt cgaatgactc taatacctct tgcaacttgg 420
acgaccgtag tacgcattca gtccgagtac caagataatg ctctttcttc tgccactcgt 480
ctaacttcgt cggctccgtg aacaagcatt cttcctacta ggc 523
<210> 89
<211> 424
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 89
gttgaggtgg acgtcttcaa tgaaaaagta gacaaccact acatgacttc aaatggggaa 60
gctgacccgt agttcagtag taacttcttc gatgttcgtt ggatcatgtt tcgatactcg 120
tgtcacattg tccacgtctt cgaatgcgtc gtcaacttct acttcgtttg cttctcaaga 180
tgaaacattg ttcacttaga gcactaaatt gtaagcaatt tagcgaacga ctacgacagc 240
ttcgatgtct cttatcacta ttattcttcg ttatggcaca acgtaggagg cgtgatagat 300
gtgacagaca tgactgtcta ggacatcgtc gtctactgga tgaaccattt gaaatgcttc 360
gacttatatg ggcatgttgc ccacttaccg tactggttcg actattatag aagggtcttg 420
acag 424
<210> 90
<211> 2467
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 90
gtggagaagc aaatacttgg ataccgaatt tagaggccat aggttatgga aaaagtcagt 60
ggattagata gtaaaagtcg aaatctttat attcggttcg atgtactacg ttattcgcga 120
ctgttctgtc atgatagttt tttatatagt cctaataaaa ggagttttta aagtaaatga 180
catttcagta gtaaaagttt aagagctttt tgttctgcca gacgttctga tagttgagga 240
aaacgtgtgg tcagctaata acttgtggta tggagtaaac gaacatccaa cagtatgtac 300
aatcgtatga gaaaggacaa atctgaagac gatattagag ggagtccaac aagtttgtga 360
tgattcacgt aaggaaatcg aaatgtaaga ttattcgtca atggaggtat aagacaacac 420
accaagtaat tatacgcgac gagttttcat gttgacgatc cctgagacta tatcatacaa 480
aattgaccca aataataaac tcgttccaat agttgaagtg ttgattaaca cattgagaca 540
agttgtccgt actttaatca tcaaagtttt ggactgacct ataaatgaaa tattcgcgtt 600
gtcttcagtt taagaagtga tattattttc ggtttcaagc ctatgtggag agatacagga 660
aataggtaaa ctataactaa tataaatata cgcagacgaa gcctgttaac tttaccaaat 720
ccaaatagcg ggagacacta aacttacaag aaatgtacgg taagacaggg aaacagggtt 780
tgaagtttgg aggtacaaaa tcttaatcct tcacaactga atcaacattt acattcggtt 840
acgttcgggg tttgtagtag taattgttga ggtaatttta attgcactta cagacgtgga 900
tttggtgaaa cattatgtgg tagattcata tttccgaatc ttaatagacg attttatgat 960
ggtgatcgtg gtttcttttc aaggtttggt ggacgaaaat gaaaaaatca caatttaacg 1020
tttcatattc atcacaatcc gaaatcgaga tggagagaaa gtttgactaa actttgttac 1080
agtatttttg aaggcaatca acctggaact ttggatttca tcaagtaaac acccatattt 1140
agcgaaaatg caagctaact gcgaactaac aaggtaactc tttttcgatt tcaaaatatg 1200
gtcagtagca atatgttaag tgatccattt tggaggggtg gggatttgtt caatgaatga 1260
ggcaataaac caccgcaacc tctgtaattg acgagaaact tgtataaggt catcaaaaag 1320
aatagatgaa cataaagatt gaatacggct gggtgaggtt aattcagatt tcccaaatta 1380
tgtagatgaa aagatggtaa gtttattgat aggtaaaaaa tcaagagagg gtaataaaga 1440
agaaagaata atcaaaagat agagcatgca aacattacat ggtagtattg ttataggcgg 1500
tatattggta aatgacgatc cttgacttag ttttttacat cgaacggttg caaatcctag 1560
catacttgat attaatagta gatactgaaa tatatctgag tatatcaagg gaaatcgaga 1620
tgtaacaata agtcgaggaa attaaggtca atttagtgct tatcatagaa ataactactt 1680
aagcccttaa cgaactaact caaattaacg aggtagaggt tattctgaat tgtacgaacg 1740
tagtcgaagt ttgttaccaa gggtaaagcc aaaacaaaac gatttgacaa gagaatctat 1800
tccatgtagt agtgcgtttg tacgacgttc tattcgatgt aaatcattag gacgagggtt 1860
tgaagcaact cggaaagatg gtcggttaga atttaaaagt actgaacgga attaacgaag 1920
ttggctacta cctaatagtc tttgcttagg atttagtagt tcgcaattgg gtcaaagtgg 1980
tcgctttggt cgtcgacgtc aagactcaac aagtcattta ccgctgtacg aaccatctca 2040
tttaacaggt tctcaaccaa atagcggtag gagtagaaag cacttaccat cgtacgaact 2100
ttgacaacga aaggttcaaa ggtaaccaag gcgtagtagt gagttaggtc aatgtataaa 2160
aactcccttt cttattttga gtcgtcaatg tagtcgagaa agtatgcact tagtgccatt 2220
attattagac aagatagtcc gttctttagt cgaagttctt gttgtaataa caaaagtaga 2280
gcagattacg atccgaaatt tcatggacac agatatttga gatcaacatt tgattcgttg 2340
acgtatttat gttgattcgg ttagcgagag ttacaaagtt agtaatagaa agaaagagga 2400
aataataatc aaaagattaa gcatgcaaac attaagagga cacatatgta ttggtggcat 2460
ttgcgtt 2467
<210> 91
<211> 1807
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 91
gataccgaat ttagaggcca taggttatgg aaaaagtcag tggagtaaac gaacatccaa 60
cagtatgtac aatcgtatga gaaaggacaa atctgaagac gatattagag ggagtccaac 120
aagtttgtga tgattcacgt aaggaaatcg aaatgtaaga ttattcgtca atggaggtat 180
aagacaacac accaagtaat tatacgcgac gagttttcat gttgacgatc cctgagacta 240
tatcatacaa aattgaccca aataataaac tcgttccaat agttgaagtg ttgattaaca 300
cattgagaca agttgtccgt actttaatca tcaaagtttt ggactgacct ataaatgaaa 360
tattcgcgtt gtcttcagtt taagaagtga tattattttc ggtttcaagc ctatgtggag 420
agatacagga aataggtaaa ctataactaa tataaatata cgcagacgaa gcctgttaac 480
tttaccaaat ccaaatagcg ggagacacta aacttacaag aaatgtacgg taagacaggg 540
aaacagggtt tgaagtttgg aggtacaaaa tcttaatcct tcacaactga atcaacattt 600
acattcggtt acgttcgggg tttgtagtag taattgttga ggtaatttta attgcactta 660
cagacgtgga tttggtgaaa cattatgtgg tagattcata tttccgaatc ttaatagacg 720
attttatgat ggtgatcgtg gtttcttttc aaggtttggt ggacgaaaat gaaaaaatca 780
caatttaacg tttcatattc atcacaatcc gaaatcgaga tggagagaaa gtttgactaa 840
actttgttac agtatttttg aaggcaatca acctggaact ttggatttca tcaagtaaac 900
acccatattt agcgaaaatg caagctaact gcgaactaac aaggtaactc tttttcgatt 960
tcaaaatatg gtcagtagca atatgttaag tgatccattt tggaggggtg gggatttgtt 1020
caatgaatga ggcaataaac caccgcaacc tctgtaattg acgagaaact tgtataaggt 1080
catcaaaaag aatagatgaa cataaagatt gaatacggct gggtgaggtt aattcagatt 1140
tcccaaatta tgtagatgaa aagatggtaa gtttattgat aggtaaaaaa tcaagagagg 1200
gtaataaaga agaaagaata atcaaaagat agagcatgca aacattacat ggtagtattg 1260
ttataggcgg tatattggta aatgacgatc cttgacttag ttttttacat cgaacggttg 1320
caaatcctag catacttgat attaatagta gatactgaaa tatatctgag tatatcaagg 1380
gaaatcgaga tgtaacaata agtcgaggaa attaaggtca atttagtgct tatcatagaa 1440
ataactactt aagcccttaa cgaactaact caaattaacg aggtagaggt tattctgaat 1500
tgtacgaacg tagtcgaagt ttgttaccaa gggtaaagcc aaaacaaaac gatttgacaa 1560
gagaatctat tccatgtagt agtgcgtttg tacgacgttc tattcgatgt aaatcattag 1620
gacgagggtt tgaagcaact cggaaagatg gtcggttaga atttaaaagt actgaacgga 1680
attaacgaag ttggctacta cctaatagtc tttgcttagg atttagtagt tcgcaattgg 1740
gtcaaagtgg tcgctttggt cgtcgacgtc aagactcaac aagtcattta ccgctgtacg 1800
aaccatc 1807
<210> 92
<211> 2018
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 92
gataccgaat ttagaggcca taggttatgg aaaaagtcag tggattagat agtaaaagtc 60
gaaatcttta tattcggttc gatgtactac gttattcgcg actgttctgt catgatagtt 120
ttttatatag tcctaataaa aggagttttt aaagtaaatg acatttcagt agtaaaagtt 180
taagagcttt ttgttctgcc agacgttctg atagttgagg aaaacgtgtg gtcagctaat 240
aacttgtggt atggagtaaa cgaacatcca acagtatgta caatcgtatg agaaaggaca 300
aatctgaaga cgatattaga gggagtccaa caagtttgtg atgattcacg taaggaaatc 360
gaaatgtaag attattcgtc aatggaggta taagacaaca caccaagtaa ttatacgcga 420
cgagttttca tgttgacgat ccctgagact atatcataca aaattgaccc aaataataaa 480
ctcgttccaa tagttgaagt gttgattaac acattgagac aagttgtccg tactttaatc 540
atcaaagttt tggactgacc tataaatgaa atattcgcgt tgtcttcagt ttaagaagtg 600
atattatttt cggtttcaag cctatgtgga gagatacagg aaataggtaa actataacta 660
atataaatat acgcagacga agcctgttaa ctttaccaaa tccaaatagc gggagacact 720
aaacttacaa gaaatgtacg gtaagacagg gaaacagggt ttgaagtttg gaggtacaaa 780
atcttaatcc ttcacaactg aatcaacatt tacattcggt tacgttcggg gtttgtagta 840
gtaattgttg aggtaatttt aattgcactt acagacgtgg atttggtgaa acattatgtg 900
gtagattcat atttccgaat cttaatagac gattttatga tggtgatcgt ggtttctttt 960
caaggtttgg tggacgaaaa tgaaaaaatc acaatttaac gtttcatatt catcacaatc 1020
cgaaatcgag atggagagaa agtttgacta aactttgtta cagtattttt gaaggcaatc 1080
aacctggaac tttggatttc atcaagtaaa cacccatatt tagcgaaaat gcaagctaac 1140
tgcgaactaa caaggtaact ctttttcgat ttcaaaatat ggtcagtagc aatatgttaa 1200
gtgatccatt ttggaggggt ggggatttgt tcaatgaatg aggcaataaa ccaccgcaac 1260
ctctgtaatt gacgagaaac ttgtataagg tcatcaaaaa gaatagatga acataaagat 1320
tgaatacggc tgggtgaggt taattcagat ttcccaaatt atgtagatga aaagatggta 1380
agtttattga taggtaaaaa atcaagagag ggtaataaag aagaaagaat aatcaaaaga 1440
tagagcatgc aaacattaca tggtagtatt gttataggcg gtatattggt aaatgacgat 1500
ccttgactta gttttttaca tcgaacggtt gcaaatccta gcatacttga tattaatagt 1560
agatactgaa atatatctga gtatatcaag ggaaatcgag atgtaacaat aagtcgagga 1620
aattaaggtc aatttagtgc ttatcataga aataactact taagccctta acgaactaac 1680
tcaaattaac gaggtagagg ttattctgaa ttgtacgaac gtagtcgaag tttgttacca 1740
agggtaaagc caaaacaaaa cgatttgaca agagaatcta ttccatgtag tagtgcgttt 1800
gtacgacgtt ctattcgatg taaatcatta ggacgagggt ttgaagcaac tcggaaagat 1860
ggtcggttag aatttaaaag tactgaacgg aattaacgaa gttggctact acctaatagt 1920
ctttgcttag gatttagtag ttcgcaattg ggtcaaagtg gtcgctttgg tcgtcgacgt 1980
caagactcaa caagtcattt accgctgtac gaaccatc 2018
<210> 93
<211> 1083
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 93
gataccgaat ttagaggcca taggttatgg aaaaagtcag tggtacgaat tacgaacacc 60
ttaacattag ggaaacttag atagttgtac aaagtaacgt ataacaagta tcgcgtatgg 120
attagatagt aaaagtcgaa atctttatat tcggttcgat gtactacgtt attcgcgact 180
gttctgtcat gatagttttt tatatagtcc taataaaagg agtttttaaa gtaaatgaca 240
tttcagtagt aaaagtttaa gagctttttg ttctgccaga cgttctgata gttgaggaaa 300
acgtgtggtc agctaataac ttgtggtatg gagtaaacga acatccaaca gtatgtacaa 360
tcgtatgaga aaggacaaat ctgaagacga tattagaggg agtccaacaa gtttgtgatg 420
attcacgtaa ggaaatcgaa atgtaagatt attcgtcaat ggaggtataa gacaacacac 480
caagtaatta tacgcgacga gttttcatgt tgacgatccc tgagactata tcatacaaaa 540
ttgacccaaa taataaactc gttccaatag ttgaagtgtt gattaacaca ttgagacaag 600
ttgtcctatt gttataggcg gtatattggt aaatgacgat ccttgactta gttttttaca 660
tcgaacggtt gcaaatccta gcatacttga tattaatagt agcatcgtac gaactttgac 720
aacgaaaggt tcaaaggtaa ccaaggcgta gtagtgagtt aggtcaatgt ataaaaactc 780
cctttcttat tttgagtcgt caatgtagtc gagaaagtaa gatgcactta gtgccattat 840
tattagacaa gatagtccgt tctttagtcg aagttcttgt tgtaataaca aaagtagagc 900
agattacgat ccgaaatttc atggacacag atatttgaga tcaacatttg attcgttgac 960
gtatttatgt tgattcggtt agcgagagtt acaaagttag taatagaaag aaagaggaaa 1020
taataatcaa aagattaagc atgcaaacat taagaggaca catatgtatt ggtggcattt 1080
gcg 1083
<210> 94
<211> 436
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 94
gtacgaatta cgaacacctt aacattaggg aaacttagat agttgtacaa agtaacgtat 60
aacaagtatc gcgtatggat tagatagtaa aagtcgaaat ctttatattc ggttcgatgt 120
actacgttat tcgcgactgt tctgtcatga tagtttttta tatagtccta ataaaaggag 180
tttttaaagt aaatgacatt tcagtagtaa aagtttaaga gctttttgtt ctgccagacg 240
ttctgatagt tgaggaaaac gtgtggtcag ctaataactt gtggtatgtt tggaggtaca 300
aaatcttaat ccttcacaac tgaatcaaca tttacattcg gttacgttcg gggtttgtag 360
tagtaattgt tgaggtaatt ttaattgcac ttacagacgt ggatttggtg aaacattatg 420
tggtagattc atattt 436
<210> 95
<211> 2373
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 95
gtggagaagc aaatacttgg ataccgaatt tagaggccat aggttatgga aaaagtcagt 60
ggtacgaatt acgaacacct taacattagg gaaacttaga tagttgtaca aagtaacgta 120
taacaagtat cgcgtatgga gtaaacgaac atccaacagt atgtacaatc gtatgagaaa 180
ggacaaatct gaagacgata ttagagggag tccaacaagt ttgtgatgat tcacgtaagg 240
aaatcgaaat gtaagattat tcgtcaatgg aggtataaga caacacacca agtaattata 300
cgcgacgagt tttcatgttg acgatccctg agactatatc atacaaaatt gacccaaata 360
ataaactcgt tccaatagtt gaagtgttga ttaacacatt gagacaagtt gtccgtactt 420
taatcatcaa agttttggac tgacctataa atgaaatatt cgcgttgtct tcagtttaag 480
aagtgatatt attttcggtt tcaagcctat gtggagagat acaggaaata ggtaaactat 540
aactaatata aatatacgca gacgaagcct gttaacttta ccaaatccaa atagcgggag 600
acactaaact tacaagaaat gtacggtaag acagggaaac agggtttgaa gtttggaggt 660
acaaaatctt aatccttcac aactgaatca acatttacat tcggttacgt tcggggtttg 720
tagtagtaat tgttgaggta attttaattg cacttacaga cgtggatttg gtgaaacatt 780
atgtggtaga ttcatatttc cgaatcttaa tagacgattt tatgatggtg atcgtggttt 840
cttttcaagg tttggtggac gaaaatgaaa aaatcacaat ttaacgtttc atattcatca 900
caatccgaaa tcgagatgga gagaaagttt gactaaactt tgttacagta tttttgaagg 960
caatcaacct ggaactttgg atttcatcaa gtaaacaccc atatttagcg aaaatgcaag 1020
ctaactgcga actaacaagg taactctttt tcgatttcaa aatatggtca gtagcaatat 1080
gttaagtgat ccattttgga ggggtgggga tttgttcaat gaatgaggca ataaaccacc 1140
gcaacctctg taattgacga gaaacttgta taaggtcatc aaaaagaata gatgaacata 1200
aagattgaat acggctgggt gaggttaatt cagatttccc aaattatgta gatgaaaaga 1260
tggtaagttt attgataggt aaaaaatcaa gagagggtaa taaagaagaa agaataatca 1320
aaagatagag catgcaaaca ttacatggta gtattgttat aggcggtata ttggtaaatg 1380
acgatccttg acttagtttt ttacatcgaa cggttgcaaa tcctagcata cttgatatta 1440
atagtagata ctgaaatata tctgagtata tcaagggaaa tcgagatgta acaataagtc 1500
gaggaaatta aggtcaattt agtgcttatc atagaaataa ctacttaagc ccttaacgaa 1560
ctaactcaaa ttaacgaggt agaggttatt ctgaattgta cgaacgtagt cgaagtttgt 1620
taccaagggt aaagccaaaa caaaacgatt tgacaagaga atctattcca tgtagtagtg 1680
cgtttgtacg acgttctatt cgatgtaaat cattaggacg agggtttgaa gcaactcgga 1740
aagatggtcg gttagaattt aaaagtactg aacggaatta acgaagttgg ctactaccta 1800
atagtctttg cttaggattt agtagttcgc aattgggtca aagtggtcgc tttggtcgtc 1860
gacgtcaaga ctcaacaagt catttaccgc tgtacgaacc atctcattta acaggttctc 1920
aaccaaatag cggtaggagt agaaagcact taccatcgta cgaactttga caacgaaagg 1980
ttcaaaggta accaaggcgt agtagtgagt taggtcaatg tataaaaact ccctttctta 2040
ttttgagtcg tcaatgtagt cgagaaagtg tccaagcaaa acgtaacgaa acggttgagt 2100
aaggacttgc acactatgcc cttgcgggtt tacctgcttg acgtagtcct gccacttatt 2160
atccgtgatt gttacctaat ggacaaccta atcgttagct taaagaagat gcacttagtg 2220
ccattattat tagacaagat agtccgttct ttagtcgaag ttcttgttgt aataacaaaa 2280
gtagagcagt attttgacgt atagggagac agtcattagg tcattaaccc agttactaag 2340
gacaacgtaa ccatcgaagt tattgaactt cag 2373
<210> 96
<211> 779
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 96
gataccgaat ttagaggcca taggttatgg aaaaagtcag tggtacgaat tacgaacacc 60
ttaacattag ggaaacttag atagttgtac aaagtaacgt ataacaagta tcgcgtatga 120
tagtaaaagt cgaaatcttt atattcggtt cgatgtacta cgttattcgc gactgttctg 180
tcatgatagt tttttatata gtcctaataa aaggagtttt taaagtaaat gacatttcag 240
tagtaaaagt ttaagagctt tttgttctgc cagacgttct gatagttgag gaaaacgtgt 300
ggtcagctaa taacttgtgg agtaaacgaa catccaacag tatgtacaat cgtatgagaa 360
aggacaaatc tgaagacgat attagaggga gtccaacaag tttgtgatga ttcacgtaag 420
gaaatcgaaa tgtaagatta ttcgtcaatg gaggtataag acaacacacc aagtaattat 480
acgcgacgag ttttcatgtt gacgatccct gagactatat catacaaaat tgacccaaat 540
aataaactcg ttccaatagt tgaagtgttg attaacacat tgagacaagt tgtccgatta 600
cgatccgaaa tttcatggac acagatattt gagatcaaca tttgattcgt tgacgtattt 660
atgttgattc ggttagcgag agttacaaag ttagtaatag aaagaaagag gaaataataa 720
tcaaaagatt aagcatgcaa acattaagag gacacatatg tattggtggc atttgcgtt 779
<210> 97
<211> 479
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 97
ggcctctaaa ttcggtatcc aagtatttgc ttctccacct gccaagcgca cataaattct 60
ttgcgagtgt tgtttggcca cttttggtag ctcctgtttc ttggcaattt tggctgacac 120
gttcagtttc ttttgctcca acttcgtaag cagttagtgt aggcgtgcgc taaggcattg 180
cgctactcgc ttccatcgtt ggttctacca cccatatgcc atggcgtcct gtaagtttgc 240
gcctaattac tcgaagcgct ttcatttcta cgaaacgttt tggaataatg tcaacttggg 300
cattgttgaa actacggctt ccttaatgct cttgacaacc ttgtttagtt gttgttcttc 360
cttcttccag catttaataa ccggcttttg ttttaactcc ttcgcttttt cgactttctc 420
ctttagcacc gcaacgttct ttttaagcta caacgctttc ttgaaatgct tctcgtcat 479
<210> 98
<211> 796
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 98
gtattagggc gcattgcgct ttgccgaacg cgtaattaca gaacttgtgg tttcggtttt 60
gtcgatagcg actggaactg ccgaactttg tttaataatt acacgttaat ctgggacaaa 120
aggcaagctg aagatcgcag taacagttgg ttctgcgaaa gttgaccaac ctatgcgact 180
ttctggtttt gcctgttatg aacaacgttg gcaggtaaag aagcggctga ctgctggtcg 240
aagagccaaa tggtcaacat tagcatagct tgtttcgtaa tcgattggct caactgccgc 300
cgtgtccacg cgttaaacgc ggttagtaac atccactgaa ctttcttcgc caacagtaca 360
agctggcagt tgcatgtctt tagtacagga gattgcaacg ctacctacgc aagctttgac 420
tgcgatgcta caccgcacga tagctcgcgt acctacactt ttacgcgcta ctactccgcg 480
aacataagcc acttcatgtt gaacgaatgg agaacgttat ggttcacttc tttatgcgac 540
cgaagaaggc gcagtgtttg cttgacaatt tactgtcgtg tcttcggtaa cagatatgct 600
accaagcgac ctaaccactt taagcagctt caccgtctta cgagacgtta acctaacgca 660
aatgccacca atacatatgt gtcctcttaa tgtttgcatg cttaatcttt tgattattat 720
ttcctctttc tttctattac taactttgta actctcgcta accgaatcaa cataaatacg 780
tcaacgaatc aaatgt 796
<210> 99
<211> 589
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 99
gcgtaattac agaacttgtg gtttcggttt tgtcgatagc gactggaact gccgaacttt 60
gtttaataat tacacgttaa tctgggacaa aaggcaagct gaagatcgca gtaacagttg 120
gttctgcgaa agttgaccaa cctatgcgac tttctggttt tgcctgttat gaacaacgtt 180
ggcaggtaaa gaagcggctg actgctggtc gaagagccaa atggtcaaca ttagcatagc 240
ttgtttcctc tttttcgttg cggagttaag taggagaacg ttatggttca cttctttatg 300
cgaccgaaga aggcgcagtg tttgcttgac aatttactgt cgtgtcttcg gtaacagata 360
tgctaccaag cgacctaacc accttcaccg tcttacgaga cgttaaccta acgcaaatgc 420
caccaataca tatgtgtcct cttaatgttt gcatgcttaa tcttttgatt attatttcct 480
ctttctttct attactaact ttgtaactct cgctaaccga atcaacataa atacgtcaac 540
gaatcaaatg ttgatctcaa atatctgtgt ccatgaaatt tcggatcgt 589
<210> 100
<211> 161
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 100
gctgaccaca cgttttcctc aactatcaga acgtctggca gaacaaaaag ctcttaaact 60
tttactactg aaatgtcatt tactttaaaa actcctttta ttaggactat ataaaaaact 120
atcatgacag aacagtcgcg aataacgtag tacatcgaac c 161
<210> 101
<211> 2253
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 101
gttgaactta tacagaaata ctaaaagtcg aacaaccatt cgatttagga atacagaacg 60
ataacgcagc agaagtagtt gaccaccgtg taacttgaat ggtgatggtc ctggttctat 120
taatacaaat ccttttactt atgctccgtg atacagaaca actaaaagaa ctaaaagaga 180
agaacgacgt gcacgtgcta attatgcgaa ttaacatcgg gttagaaaaa gtaaactaaa 240
ggaaaatggg taaggcatat gccttactaa attgtgtaaa agaagttcta ataagaaccg 300
gaatgtatgt aattattcgc aagggttcca taaggcacat atacaaattt agaaacaacc 360
cgttacatta acaaaggtga acggtgtttc acagatatta gaccattagg taaccaatga 420
catttcacta tcgaaaaggg tatagtatta actactacaa ctaatccgac tcgtcgaggt 480
gatttataca ggactgcagg tagcaaacga cgaggtggac gagggtaagg tggccgacga 540
aagggaggac atgcacctag ttgaacacga ctaggaggac gatggccact acggagtgga 600
acacaaaggt aaagttgcaa taataaccag tacaacaaaa gcatacgtgg aaggtgacaa 660
gcaaacgatg tcttgaacaa caccgtcttc attgtttacc atttgctgtt ggatttgata 720
tttagagcgt atgttgaaga agttggaact ctggacacat tagagactta ttggatcgat 780
caagaggaat gcaatacgaa gtagtttcac tttcgtaggt taccctataa cacgcaaata 840
gatgtaatca acctcttatt aatcatacac tagacatcag atgttaatga cctaacgatt 900
atagtgctga acaacgtcta cgacaatata aacctttgca aagactggtc aaacatcaat 960
gttaaacacg tccagataaa agcaaaaagg taagacgagg attacggaat aattaatata 1020
gtgcttgttc caatcggccc ggcttcagtc attcccggtg gcgaagccat aacatttaaa 1080
aatagcctgt taacttcaag ctgtagtagc ctaaacaggt ttcctaatag tatgcaaaca 1140
acatagttca atagaagtta ttaataaaca tcaaattgtc tttgaacaac acaaacacgt 1200
aagctttcgg caactaaatt aactaaaaaa taactataat tacacagaac acgaagtcat 1260
ctgtttccta ttaaaaaata ggtacttgac aggttacaat ataacctgtt tctagcatgt 1320
ataacaaaat taagcgacga ccgagcgacg acaacaagca gcagccaggt gggcaaaagg 1380
ctaagactgc tttgatgtcc tgagccaact tgccgatacg cagcaacatt ttagaaacgt 1440
catcctgacc gccgccgcca ttgccataaa tgatagcttg gcggtagccg cccaaaacta 1500
tgaaaaaaat taaattaagg aaagacataa acaaggtagt taagccatgc acctagaaaa 1560
ttttgaacgg ctcagctgca acatattagc gctagaaatg acctaccata atgatataga 1620
agataattac cattactgcc accgcctcct ccgctgccgc ctcctccata gcagcttcta 1680
ttcaaacaaa ctccgccgcc gccaccgccg ccataaccac caccataacc accgccgtat 1740
acacaaacgc cgctccttct aagtcttagc tattaataac aaccgtggaa acaaaaaacg 1800
taatataggc tacagctgtg tcaacagcca aatccataac aacaaaatcc atggtgactg 1860
taacagacac tgttacaacc atattattaa ctagatagtg gttacagata atcatgcagc 1920
aacaacatat aaagaagacg gttaaagtta ttgacttatg ttagcatgtg caaattaaca 1980
taggctagtc ttaacctgac tcgctgtcgc gactggcatg caaagtttga cacgccgcgg 2040
ctctagtacg cgtcatcttt cagctgtaat aactacaaac acatcaaaaa aagtcggttt 2100
aaaacaactt gtgaaacgtc aacttggtaa ataaacctat tattaaagaa tctagatcaa 2160
tgtccaaaaa gattatttcc attgttacgt ctaaatacag attctgcgaa aacaagccat 2220
tagtatagta gaagaactaa ccatcgtatg ttc 2253
<210> 102
<211> 2059
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 102
gtgtaaccat cttacggatg taatctaacg taaacaccag agaaacaacc atcaaaacgg 60
cataatgggc aagcattatt aggaacatct aaatataaaa ccattgcctt aactcacata 120
acgctacact tggtaacacc accatatgca gtgcaagaac gttgggtaag agaacatcga 180
acgtatggtc tgtttacata agctcaaaaa taattttaca gggtaaaacg tcaatcatta 240
cttaacagca gtaatgctta caaatgtttc ggttagtatt taaaaccgta acgaacgcca 300
cgtgtaaaaa caagaggttt tattaatatt gggtatatta gatgtatccg tcgattaacc 360
caccataacc aaactaaatt aaagcaacga cttatgcgaa atcctccttg tttacaaact 420
aacagtaatg caagtcgtaa taaacgtctt aaatatttta taggtaaaag atttggacca 480
tatcctcagt actgtaatga taaacaccga cgaagtctac atcgttgcaa cggaaaattc 540
catgaaagtc gtatgtttta tggtaaactt ccgaatttag caaaaagggt tgtaaaaggt 600
atacgtcatc atggtaagaa atacagctgt attagtatat aaggttgtag aaaaccacat 660
aataatatgt ctttagcact agacatcaga tgttaatgac ctaacgatta tagtgctgaa 720
caacgtctac gacaatataa acctttgcaa agactggtca aacatcaatg ttaaacacgt 780
ccagataaaa gcaaaaaggt aagacgagga ttacggaata attaatatag tgcttgttcc 840
aatcggcccg gcttcagtca ttcccggtgg cgaagccata acatttaaaa atagcctgtt 900
aacttcaagc tgtagtagcc taaacaggtt tcctaatagt atgcaaacaa catagttcaa 960
tagaagttat taataaacat caaattgtct ttgaacaaca caaacacgta agctttcggc 1020
aactaaatta actaaaaaat aactataatt acacagaaca cgaagtcatc tgtttcctat 1080
taaaaaatag gtacttgaca ggttacaata taacctgttt ctagcatgta taacaaaatt 1140
aagcgacgac cgagcgacga caacaagcag cagccaggtg ggcaaaaggc taagactgct 1200
ttgatgtcct gagccaactt gccgatacgc agcaacattt tagaaacgtc atcctgaccg 1260
ccgccgccat tgccataaat gatagcttgg cggtagccgc ccaaaactat gaaaaaaatt 1320
aaattaagga aagacataaa caaggtagtt aagccatgca cctagaaaat tttgaacggc 1380
tcagctgcaa catattagcg ctagaaatga cctaccataa tgatatagaa gataattacc 1440
attactgcca ccgcctcctc cgctgccgcc tcctccatag cagcttctat tcaaacaaac 1500
tccgccgccg ccaccgccgc cataaccacc accataacca ccgccgtata cacaaacgcc 1560
gctccttcta agtcttagct attaataaca accgtggaaa caaaaaacgt aatataggct 1620
acagctgtgt caacagccaa atccataaca acaaaatcca tggtgactgt aacagacact 1680
gttacaacca tattattaac tagatagtgg ttacagataa tcatgcagca acaacatata 1740
aagaagacgg ttaaagttat tgacttatgt tagcatgtgc aaattaacat aggctagtct 1800
taacctgact cgctgtcgcg actggcatgc aaagtttgac acgccgcggc tctagtacgc 1860
gtcatctttc agctgtaata actacaaaca catcaaaaaa agtcggttta aaacaacttg 1920
tgaaacgtca acttggtaaa taaacctatt attaaagaat ctagatcaat gtccaaaaag 1980
attatttcca ttgttacgtc taaatacaga ttctgcgaaa acaagccatt agtatagtag 2040
aagaactaac catcgtatg 2059
<210> 103
<211> 670
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 103
gtgaaaggtg atacatattt acttgacttc ttaagcagag agcgtcaaaa caggttgaac 60
ttatacagaa atactaaaag tcgaacaacc attcgattta ggagtgcaga tacagaacaa 120
ctaaaagaac taaaagagaa gaacgacgtg cacgtgctaa ttatgcgaat taacatcggg 180
ttagaaaaag taaactaaag gaaaatgggt aaggcatatg ccttactaaa ttgtgtaaaa 240
gaagttctaa taagaaccgg aatgtatgta attattcgca agggttccat aaggcacata 300
tacaaattta gaaacaaccc gttacattaa caaaggtgaa cggtgtttca cagatattag 360
accattaggt aaccaatgac atttcactat cgaaaagggt atagtattaa ctactacaac 420
taatccgact cgtcgaggtg atttatacag gactgcaggt agcaaacgac gaggtggacg 480
agggtaaggt ggccgacgaa agggaggaca tgcacctagt tgaacacgac taggaggacg 540
atggccacta cggagtggaa cacaaaggta aagttgcaat aataaccagt acaacaaaag 600
catacgtgga aggtgacaag caaacgatgt cttgaacaac accgtcttca ttgtttacca 660
tttgctgttg 670
<210> 104
<211> 592
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 104
gcaattagga tcaggtggtt aatctgatac gatacagaac aactaaaaga actaaaagag 60
aagaacgacg tgcacgtgct aattatgcga attaacatcg ggttagaaaa agtaaactaa 120
aggaaaatgg gtaaggcata tgccttacta aattgtgtaa aagaagttct aataagaacc 180
ggaatgtatg taattattcg caagggttcc ataaggcaca tatacaaatt tagaaacaac 240
ccgttacatt aacaaaggtg aacggtgttt cacagatatt agaccattag gtaaccaatg 300
acatttcact atcgaaaagg gtatagtatt aactactaca actaatccga ctcgtcgagg 360
tgatttatac aggactgcag gtagcaaacg acgaggtgga cgagggtaag gtggccgacg 420
aaagggagga catgcaccta gttgaacacg actaggagga cgatggccac tacggagtgg 480
aacacaaagg taaagttgca ataataacca gtacaacaaa agcatacgtg gaaggtgaca 540
agcaaacgat gtcttgaaca acaccgtctt cattgtttac catttgctgt tg 592
<210> 105
<211> 626
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 105
gccaaggtga accaggacga agtcgatgtt tcagaacctc ctttaggcct tttagacggt 60
ttaaacgaag cactagacca agtaataaaa gcggacgttg cacaggtacg tgcagataca 120
gaacaactaa aagaactaaa agagaagaac gacgtgcacg tgctaattat gcgaattaac 180
atcgggttag aaaaagtaaa ctaaaggaaa atgggtaagg catatgcctt actaaattgt 240
gtaaaagaag ttctaataag aaccggaatg tatgtaatta ttcgcaaggg ttccataagg 300
cacatataca aatttagaaa caacccgtta cattaacaaa ggtgaacggt gtttcacaga 360
tattagacca ttaggtaacc aatgacattt cactatcgaa aagggtatag tattaactac 420
tacaactaat ccgactcgtc gaggtgattt atacaggact gcaggtagca aacgacgagg 480
tggacgaggg taaggtggcc gacgaaaggg aggacatgca cctagttgaa cacgactagg 540
aggacgatgg ccactacgga gtggaacaca aaggtaaagt tgcaataata accagtacaa 600
caaaagcata cgtggaaggt gacaag 626
<210> 106
<211> 617
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 106
gacatcagat gttaatgacc taacgattat agtgctgaac aacgtctacg acaatataaa 60
cctttgcaaa gactggtcaa acatcaatgt taaacacgtc cagataaaag caaaaaggta 120
agacgaggat tacggaataa ttaatatagt gcttgttcca atcggcccgg cttcagtcat 180
tcccggtggc gaagccatgt caccaataaa aactatcggc ggcaatggaa gtggtttttc 240
ggaaactgtt acgggtgcaa gcggccccag tgcagtttgt gccttgccaa tcggcccagc 300
tttcaaacgc aaagttggac gacttattgg cccattctga caacgtcctg ttaaactgcc 360
cggacgttca aacggcggta tcggacgact aacgcgttac ggcggacaac tcgcccccag 420
tcaacaactt ggacacggta aatttgaacg ctaagtcaac tgtagcagtt aaacattgag 480
tattaaaata gatttaagct agcgttaaga acattaaaaa ctaaccagcc aaaccaagga 540
ttacggctgt ggtgtaatcg attgcgaaat agcatgacaa aaaacttaca gtttagaagg 600
tggcggtatt acttaag 617
<210> 107
<211> 2105
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 107
gcagatacag aacaactaaa agaactaaaa gagaagaacg acgtgcacgt gctaattatg 60
cgaattaaca tcgggttaga aaaagtaaac taaaggaaaa tgggtaaggc atatgcctta 120
ctaaattgtg taaaagaagt tctaataaga accggaatgt atgtaattat tcgcaagggt 180
tccataaggc acatatacaa atttagaaac aacccgttac attaacaaag gtgaacggtg 240
tttcacagat attagaccat taggtaacca atgacatttc actatcgaaa agggtatagt 300
attaactact acaactaatc cgactcgtcg aggtgattta tacaggactg caggtagcaa 360
acgacgaggt ggacgagggt aaggtggccg acgaaaggga ggacatgcac ctagttgaac 420
acgactagga ggacgatggc cactacggag tggaacacaa aggtaaagtt gcaataataa 480
ccagtacaac aaaagcatac gtggaaggtg acaagcaaac gatgtcttga acaacaccgt 540
cttcattgtt taccatttgc tgttggattt gatatttaga gcgtatgttg aagaagttgg 600
aactctggac acattagaga cttattggat cgatcaagag gaatgcaata cgaagtagtt 660
tcactttcgt aggttaccct ataacacgca aatagatgta atcaacctct tattaatcat 720
acactagaca tcagatgtta atgacctaac gattatagtg ctgaacaacg tctacgacaa 780
tataaacctt tgcaaagact ggtcaaacat caatgttaaa cacgtccaga taaaagcaaa 840
aaggtaagac gaggattacg gaataattaa tatagtgctt gttccaatcg gcccggcttc 900
agtcattccc ggtggcgaag ccataacatt taaaaatagc ctgttaactt caagctgtag 960
tagcctaaac aggtttccta atagtatgca aacaacatag ttcaatagaa gttattaata 1020
aacatcaaat tgtctttgaa caacacaaac acgtaagctt tcggcaacta aattaactaa 1080
aaaataacta taattacaca gaacacgaag tcatctgttt cctattaaaa aataggtact 1140
tgacaggtta caatataacc tgtttctagc atgtataaca aaattaagcg acgaccgagc 1200
gacgacaaca agcagcagcc aggtgggcaa aaggctaaga ctgctttgat gtcctgagcc 1260
aacttgccga tacgcagcaa cattttagaa acgtcatcct gaccgccgcc gccattgcca 1320
taaatgatag cttggcggta gccgcccaaa actatgaaaa aaattaaatt aaggaaagac 1380
ataaacaagg tagttaagcc atgcacctag aaaattttga acggctcagc tgcaacatat 1440
tagcgctaga aatgacctac cataatgata tagaagataa ttaccattac tgccaccgcc 1500
tcctccgctg ccgcctcctc catagcagct tctattcaaa caaactccgc cgccgccacc 1560
gccgccataa ccaccaccat aaccaccgcc gtatacacaa acgccgctcc ttctaagtct 1620
tagctattaa taacaaccgt ggaaacaaaa aacgtaatat aggctacagc tgtgtcaaca 1680
gccaaatcca taacaacaaa atccatggtg actgtaacag acactgttac aaccatatta 1740
ttaactagat agtggttaca gataatcatg cagcaacaac atataaagaa gacggttaaa 1800
gttattgact tatgttagca tgtgcaaatt aacataggct agtcttaacc tgactcgctg 1860
tcgcgactgg catgcaaagt ttgacacgcc gcggctctag tacgcgtcat ctttcagctg 1920
taataactac aaacacatca aaaaaagtcg gtttaaaaca acttgtgaaa cgtcaacttg 1980
gtaaataaac ctattattaa agaatctaga tcaatgtcca aaaagattat ttccattgtt 2040
acgtctaaat acagattctg cgaaaacaag ccattagtat agtagaagaa ctaaccatcg 2100
tatgt 2105
<210> 108
<211> 570
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 108
gtgaaaggtg atacatattt acttgacttc ttaagcagag agcgtcaaaa caggttgaac 60
ttatacagaa atactaaaag tcgaacaacc attcgattta ggagtgcaga tacagaacaa 120
ctaaaagaac taaaagagaa gaacgacgtg cacgtgctaa ttatgcgaat taacatcggg 180
ttagaaaaag taaactaaag gaaaatgggt aaggcatatg ccttactaaa ttgtgtaaaa 240
gaagttctaa taagaaccgg aatgtatgta attattcgca agggttccat aaggcacata 300
tacaaattta gaaacaaccc gttacattaa caaaggtgaa cggtgtttca cagatattag 360
accattaggt aaccaatgac atttcactat cgaaaagggt ataggaggac atgcacctag 420
ttgaacacga ctaggaggac gatggccact acggagtgga acacaaaggt aaagttgcaa 480
taataaccag tacaacaaaa gcatacgtgg aaggtgacaa gcaaacgatg tcttgaacaa 540
caccgtcttc attgtttacc atttgctgtt 570
<210> 109
<211> 1567
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 109
gtgtagcata gcaactgttc tgaatgtgat attcggtcag gccacgttga cacttaccaa 60
agcaagacag aaggaagttg acgggacaat agggaagatt ggcaaaggga tttaaacata 120
gtccagttcg cgtggtgaat gacagattgc tactgttacc attggcgata ctacgttggc 180
gactttactt gcctcggtag cgacagaaca agtgtcgtct acgcaacgaa caaccagcgt 240
gttagctgca atgtcccctg tagaagaccc tcttctttct cttctgaatg atgtagctgt 300
ggatagagcg tctcccacgt tagggtctag caaccctccg gtggtgtgtg gtttcggttc 360
gcttggttgg gtgcccaatt tccagtaccg aagaggtaat tgcaacttca attgcttagt 420
tgacgtgacc tttcgggtgt catggactac cgacggtatc tcatacgtga cctcgttgtt 480
gacctcgttc ttcatctgca cagactacaa cgttaggact acggaaccag tgtgaagttg 540
acggacgcgc tagaagtctg acactgacca tgcttgtggc aatcgttgtt catgtagcca 600
ctttgactcg acgttcacga acatacgatg gttagttctt ctactatact aatggcttgt 660
tttcgcagaa tctgtattta gacgtaacaa tggaaataat ctttttggac attgatctag 720
attctttaat aataggttta tttaccaagt tgacgtttca caagttgttt taaaccgact 780
ttttttgatg tgtttgtagt tattacagct gaaagatgac gcgtactaga gccgcggcgt 840
gtcaaacttt gcatgccagt cgcgacagcg agtcaggtta agactagcct atgttaattt 900
gcacatgcta acataagtca ataactttaa ccgtcttctt tatatgttgt tgctgcatga 960
ttatctgtaa ccactatcta gttaataata tggttgtaac agtgtctgtt acagtcacca 1020
tggattttgt tgttatggat ttggctgttg acacagctgt agcctatatt acgttttttg 1080
tttccacggt tgttattaat agctaagact tagaaggagc ggcgtttgtg tatacggcgg 1140
tggttatggt ggtggttatg gcggcggtgg cggcggcgga gtttgtttga atagaagctg 1200
ctatggagga ggcggcagcg gaggaggcgg tggcagtaat ggtaattatc ttctatatca 1260
ttatggtagg tcatttctag cgctaatatg ttgcagctga gccgttcaaa attttctagg 1320
tgcatggctt aactaccttg tttatgtctt tccttaattt aatttttttc atagttttgg 1380
gcggctaccg ccaagctatc atttatggca atggcggcgg cggtcaggat gacgtttcta 1440
aaatgttgct gcgtatcggc aagttggctc aggacatcaa agcagtctta gccttttgcc 1500
cacctggctg ctgcttgttg tcgtcgctcg gtcgtcgctt aattttgtta tacatgctag 1560
aaacagg 1567
<210> 110
<211> 950
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 110
gatcgtggcc cagtcagtgg attacgttga ccatgagtct ggctgttctt ggttcaccat 60
tagctgtggt gacaataacg ggcattgtgg caacgatacg tcgtactgca agtcccactg 120
taactaagac aattcggatt cgaccgatac ttggtctggt tcgttaactt cgcgtacctt 180
ctgctttacc agcaggtcgt caacgacgag ccaccgtaac gagtgtggtt tcggttcgct 240
tggttgggtg cccaatttcc agtaccgaag aggtaattgc aacttcaatt gcttagttga 300
cgtgaccttt cgggtgtcat ggactaccga cggtatctca tacgtgacct cgttgttgac 360
ctcgttcttc atctgcacag actacaacgt taggactacg gaaccagtgt gaagttgacg 420
gacgcgctag tttacagatg cggtttattg gattggttac aacggcaaag gcggagacca 480
ctccaactgt cggaagagta cctcttcaaa ttgccattcc aattgctcgt catggacttt 540
ccactcttag acgacccgat gaagctagaa gtctgacact gaccatgctt gtggcaatcg 600
ttgttcatgt agccactttg actcgacgtt cacgaacata cgatggttag ttcttctact 660
atactaatgg cttgttttcg cagaatctgt atttagacgt aacaatggaa ataatctttt 720
tggacattga tctagattct ttaataatag gtttatttac caagttgacg tttcacaagt 780
tgttttaaac cgactttttt tgatgtgttt gtagttatta cagctgaaag atgacgcgta 840
ctagagccgc ggcgtgtcaa actttgcatg ccagtcgcga cagcgagtca ggttaagact 900
agcctatgtt aatttgcaca tgctaacata agtcaataac tttaaccgtc 950
<210> 111
<211> 1890
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 111
gtagaccttt ccttgccgcg tggaacaaac cgccatgagt gttttacgtt tacggtcggc 60
gaccggagtc acagcgcgac caacggggcc aggcaaaggc ccataggctt ttccatcggc 120
acgcgaccga ttccatcaag tgttaggtgc aatccccatt cgggacggac acgcgagtaa 180
aggtctaaca tgtttcaact ttccagttag tcgccgtcct atattggcaa gaccggatgg 240
ccgtcaacca gttccattct gactatttgc cacattgatt aaagaagtag gagcgttagt 300
cggcgcgtgc gcgggactat ttagcgaagg tcgccgatcg tttgcccgta aaactaactg 360
gcaaaagcct aagtgctgtt tcgggtgcaa tggtataact tcccacattt agccgaatag 420
cgccaacagc gttattattt ggaaccaagc agtgggcgat gtcagcgaca attccacttt 480
ggtagaggtc gttcttttgt agaaaacaat ctaacataac tatgacactt tcggtaaatt 540
caccaccttt accagggtcg taagtggtca agccacgccg accacttcat aagcattggt 600
ggaaatcgca tcgacacaat aaaagtacac caaccagcag aaaacaggta catatacagt 660
ttaacgacct ggatctaaga tgactacagt agcatagcca tagaacatgg cactgaaata 720
tcgatgggcg taaaagtgaa caacgcagac gatggattac gacgccaagc cactataaat 780
gctaattgag tcgaagaagg tactcctttt tggaacacag atattgcaga agcgggaatg 840
aggttgatat tacatcaagt atcaacagac gacctcagaa gggtggtctt ttaaaatgac 900
aacgtacatt aagatgcaga caaacactac tatgctggat gtgaaaatgt catatgtgcg 960
gcaaaaatag acgacattta agaacctagc attataggat ggagtgttgt attaattcac 1020
tctagagtaa tggatcacgg tgccagaaac taaggtggtg taggactaga tgcaagtaac 1080
aacggtcgta ctaaaatcag ctacgcgatc gccgacttag aaggctgaga tggagaaact 1140
tgtctactgg cagacctcac tatcttttag gaaggtcacg aagcggctgg agtgatggct 1200
agtctcagcc actgtcaacg ggaagcgcga cgtttatggt caatataaac tagcagttta 1260
atccgtatgg cgatcttagc ggatgttaca ggatggagaa gatgacaaag tagaagctag 1320
acaactatat caaatcgttg tgtggtctta aaccgacaca gtagcattca tcgttggatg 1380
tggaaggtca cagcctcgtt ggaggagata ctacggtccc gcttttcgtg ggtgacaaag 1440
gtcgcaaagg tttccttagg gaggtcgttt cccggatctt tatctacatc tcctgggtga 1500
aggggatgat ctttctctac atagattgca gagagccagg tcaaatacat tgagaaatct 1560
gtatatgtac tttggtaacg ctctaaggta ggtacacgtt agtgatataa aaagaaggcg 1620
acgacgaact taaattgtta gagcagttta tgggtggtag gttacatcta tttacttcaa 1680
aacgcggtgc cctagcccac aagcattgct ttgtaaaatt gttgaaggta acttgtaaaa 1740
gccgaacatg aacgatggat agtagaccgg gaagaccaac gttttttcac tactccgaaa 1800
gaacacactg aagggaacgg tgtaggttcg gtgagtccgg gactaggtgt ccatgtcgga 1860
gacctcagtg gtgacgtcct cgtagtatag 1890
<210> 112
<211> 1984
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 112
gacttgtagg cccatgaatt acccgcttag gcaatgggta gacctttcct tgccgcgtgg 60
aacaaaccgc catgagtgtt ttacgtttac ggtcggcgac cggagtcaca gcgcgaccaa 120
cggggccagg caaaggccca taggcttttc catcggcacg cgaccgattc catcaagtgt 180
taggtgcaat ccccattcgg gacggacacg cgagagcgtt agtcggcgcg tgcgcgggac 240
tatttagcga aggtcgccgt atcgcgggtg gcggcgtttc cgccataaca acaagcgttt 300
aaggtcagag tccgcgacga atgaaacgcc gtgcaagcgg ctttggtacg gccagtttag 360
ccaaagcctg atccgttcgc cttgggttat catgtaccag tcaagcggtc atcgcgggcg 420
gcgttatcat ggatcgtttg cccgtaaaac taactggcaa aagcctaagt gctgtttcgg 480
gtgcaatggt ataacttccc acatttagcc gaatagcgcc aacagcgtta ttatttggaa 540
ccaagcagtg ggcgatgtca gcgacaattc cactttggta gaggtcgttc ttttgtagaa 600
aacaatctaa cataactatg acactttcgg taaattcacc acctttacca gggtcgtaag 660
tggtcaagcc acgccgacca cttcataagc attggtggaa atcgcatcga cacaataaaa 720
gtacaccaac cagcagaaaa caggtacata tacagtttaa cgacctggat ctaagatgac 780
tacagtagca tagccataga acatggcact gaaatatcga tgggcgtaaa agtgaacaac 840
gcagacgatg gattacgacg ccaagccact ataaatgcta attgagtcga agaaggtact 900
cctttttgga acacagatat tgcagaagcg ggaatgaggt tgatattaca tcaagtatca 960
acagacgacc tcagaagggt ggtcttttaa aatgacaacg tacattaaga tgcagacaaa 1020
cactactatg ctggatgtga aaatgtcata tgtgcggcaa aaatagacga catttaagaa 1080
cctagcatta taggatggag tgttgtatta attcactcta gagtaatgga tcacggtgcc 1140
agaaactaag gtggtgtagg actagatgca agtaacaacg gtcgtactaa aatcagctac 1200
gcgatcgccg acttagaagg ctgagatgga gaaacttgtc tactggcaga cctcactatc 1260
ttttaggaag gtcacgaagc ggctggagtg atggctagtc tcagccactg tcaacgggaa 1320
gcgcgacgtt tatggtcaat ataaactagc agtttaatcc gtatggcgat cttagcggat 1380
gttacaggat ggagaagatg acaaagtaga agctagacaa ctatatcaaa tcgttgtgtg 1440
gtcttaaacc gacacagtag cattcatcgt tggatgtgga aggtcacagc ctcgttggag 1500
gagatactac ggtcccgctt ttcgtgggtg acaaaggtcg caaaggtttc cttagggagg 1560
tcgtttcccg gatctttatc tacatctcct gggtgaaggg gatgatcttt ctctacatag 1620
attgcagaga gccaggtcaa atacattgag aaatctgtat atgtactttg gtaacgctct 1680
aaggtaggta cacgttagtg atataaaaag aaggcgacga cgaacttaaa ttgttagagc 1740
agtttatggg tggtaggtta catctattta cttcaaaacg cggtgcccta gcccacaagc 1800
attgctttgt aaaattgttg aaggtaactt gtaaaagccg aacatgaacg atggatagta 1860
gaccgggaag accaacgttt tttcactact ccgaaagaac acactgaagg gaacggtgta 1920
ggttcggtga gtccgggact aggtgtccat gtcggagacc tcagtggtga cgtcctcgta 1980
gtat 1984
<210> 113
<211> 526
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 113
gtcacctaaa cgtgcgaagt gtgcgaaatt accaccgtaa attcgtccta ctgaaagtgc 60
ttacgcatct tgagagagat tgcagagagc caggtcaaat acattgagaa atctgtatat 120
gtactttggt aacgctctaa ggtaggtaca cgttagtgat ataaaaagaa ggcgacgacg 180
gtagcagagg tctagaaacc gcatgaacga ccaacttatt tgaagagcta gtgcggtgga 240
attgggtcgg aagaacttaa attgttagag cagtttatgg gtggtaggtt acatctattt 300
acttcaaaac gcggtgccct agcccacaag cattgctttg taaaattgtt gaaggtaact 360
tgtaaaagcc gaacatgaac gatggatagt agaccgggaa gaccaacgtt ttttcactac 420
tccgaaagaa cacactgaag ggaacggtgt aggttcggtg agtccgggac taggtgtcca 480
tgtcggagac ctcagtggtg acgtcctcgt agtataggtc cacgct 526
<210> 114
<211> 2473
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 114
gtccacgctc taagtcgctt gcccaattgt ggctaccgca ttgctcagaa cttcgggtac 60
tggccaacct tcaagaagcc tagtcttggt gcgtcacccc agtcacgtag catacccgtc 120
atcatctatg gtcgtaggtc caacaatcgt ggcgccattg ggtaccactt catcagagct 180
gctcgcatga ccagctatat ctggaacatc gctggtgggt cttatggtcg cttttgtggg 240
aaccatcata gtcgcaagtc tggccttcgg tatggaactc gtcgtcccga ctacaaccat 300
agctagtctc ggtctcggct ttgttgcaat gcccttcgtt actacttcaa cggtcgtggt 360
gccggtcaaa ccgctcgcta aagcaagcga agaaacagct aaacttagtt gtgtcgaaac 420
atcctaagtg gtcgggttgc tcgtggagca tgcagctagc ccagaacctt tagcttgtgt 480
ggtcttcgtc tcggtagtca gaaccaggtc ggtctgaatg gttggactcg ccacatcaac 540
taggtcagct attgaagtgc caactaaagg tcgtattgaa gcaatcggtc ctatggcaag 600
tcaagtgaca gtcgtaggta tggcacttgc cgcgcctcca gaactcggtc aagctacctc 660
ataactcgga agtcgactgc tctaaagcga agttgtcaaa cgaacagcta tgccttcgag 720
taaagcaagg tgcgcaatag taaccttggt aacttcggaa ctgcgtcaag ccgctaactc 780
catcggtatg gaagtcgcta aagtcggtca aacggaagcg gctatcgtcg caactagtcg 840
aatagttgtc gaagaggcca gagcaaccat ggttgccatt gtcttcgtgg tctatgcaag 900
acgtccttgc gtcatggcct aagcatcttc ttcactggtt gctatagcgg aagtcgttac 960
cgaactggtc gccagtcgaa tcgtttgccc catggtagtc atcaccacca tcgcggaaac 1020
caacggtccg aactcacggt aggtagtcca cgtatgtagc ccacctttcg aaggaatcgt 1080
ggtcgccggt ctcctagaaa cggtatatgt cttgcgtcac gcttatggac cggtcatcct 1140
ggccagtagc cgacttgtgg tcgctatagc tttcgctagt ccctgcctta acgtgcagca 1200
tggtatggct attgtcgtcc cggctacaac cactatcgtg gtcttgaaac tggtcgtcgc 1260
tacaaccatc ctagcattgg caccagcggt cgttgaagcc gaaggtagtc tctaactggt 1320
tttcgaagct agtcaaacag tagcgccata tggcctagcc tgaaccttag aaaaaggagt 1380
cgaaggtcct aaacccgctg gtcgcgaacg aacaaaaacg gtcgttaaag gccgtccgga 1440
agcggaaggt cgtcgcccca ggtgaacaag tcctaaagaa acaaaaagtc tctgtagtct 1500
atttaaaacc caacgcaaac gcgaacgcag aatcgtctga acccacgtcc atcattacgg 1560
attatataag gtttctgttt cgttaactag gtagttattg atgtcatccg cactacaagc 1620
taacaggagg taacagatag agcatgagtg gtagtaggga tgaaacagga agtactaatt 1680
acatacaggg actcctggtt gggtgacccc gggacacgta cgtgtcctaa taaacaggag 1740
gcgggtggtt tcctatctac tacggacagg gattttcccc gagtagcgaa ggatatgaaa 1800
cttctagtta tagacatata agacgtagtc caggaagtcg gctgagtcca tgaggtcagt 1860
tttggaggag aagtagttgt cacgatcctt agttaagata acaaagtccg agtagttatc 1920
acgacttgct gactgcgtcc actatgtttc cggggtgggc atggggactt gcacacggat 1980
aactccatcc ggattattaa gacgaggtgg ggtgtgctgg gctcccagga acttcatcgg 2040
agtgacgtag aaccttcagt ttgagtccac gtaggacacc agcgctattg gtgccgacga 2100
cgagtacaaa catccggaaa cttagcatat taggtaagag tttctgtatg ctcggacgtc 2160
gtcgttagag cagacccaga aggtgtccat ggacacacat catacaagac aacttggtca 2220
acttttacgg ggctggggcc aattatcccg ggagtcctca cgatcagaaa ccgactggtt 2280
tgtcacactc tggttagagg aggggtcacc acgatgggtg agggggtggt gggtgtttat 2340
acaagagtct gggactccaa agacgatatt acgacgagac gacttatcca cgtactttgt 2400
ttcccaaacc cacgcaactc cacctttagt ccacacaaac tagtacgaga cacccggatt 2460
caaggtcgtg acc 2473
<210> 115
<211> 2029
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 115
ggaccgaagc atactgcaag acttgtaggc ccatgaatta cccgcttagg caatgggtag 60
acctttcctt gccgcgtgga acaaaccgcc atgagtgttt tacgtttacg gtcggcgacc 120
ggagtcacag cgcgaccaac ggggccaggc aaaggcccat aggcttttcc atcggcacgc 180
gaccgattcc atcaagtgtt aggtgcaatc cccattcggg acggacacgc gagagcgtta 240
gtcggcgcgt gcgcgggact atttagcgaa ggtcgccgat cgtttgcccg taaaactaac 300
tggcaaaagc ctaagtgctg tttcgggtgc aatggtataa cttcccacat ttagccgaat 360
agcgccaaca gcgttattat ttggaaccaa gcagtgggcg atgtcagcga caattccact 420
ttggtagagg tcgttctttt gtagaaaaca atctaacata actatgacac tttcggtaaa 480
ttcaccacct ttaccagggt cgtaagtggt caagccacgc cgaccacttc ataagcattg 540
gtggaaatcg catcgacaca ataaaagtac accaaccagc agaaaacagg tacatataca 600
gtttaacgac ctggatctaa gatgactaca gtagcatagc catagaacat ggcactgaaa 660
tatcgatggg cgtaaaagtg aacaacgcag acgatggatt acgacgccaa gccactataa 720
atgctaattg agtcgaagaa ggtactcctt tttggaacac agatattgca gaagcgggaa 780
tgaggttgat attacatcaa gtatcaacag acgacctcag aagggtggtc ttttaaaatg 840
acaacgtaca ttaagatgca gacaaacact actatgctgg agtgttgtat taattcactc 900
tagagtaatg gatcacggtg ccagaaacta aggtggtgta ggactagatg caagtaacaa 960
cggtcgtact aaaatcagct acgcgatcgc cgacttagaa ggctgagatg gagaaacttg 1020
tctactggca gacctcacta tcttttagga aggtcacgaa gcggctggag tgatggctag 1080
tctcagccac tgtcaacggg aagcgcgacg tttatggtca atataaacta gcagtttaat 1140
ccgtatggcg atcttagcgg atgttacagg atggagaaga tgacaaagta gaagctagac 1200
aactatatca aatcgttgtg tggtcttaaa ccgacacagt agcattcatc gttggatgtg 1260
gaaggtcaca gcctcgttgg aggagatact acggtcccgc ttttcgtggg tgacaaaggt 1320
cgcaaaggtt tccttaggga ggtcgtttcc cggatcttta tctacatctc ctgggtgaag 1380
gggatgatct ttctctacat gtcctgggtg gaggggagtt tccttgtatg ggtggaaccc 1440
aacccgccgg tgagggtgag ttacggtcgg cggtcatatg tgggtatgac gggtatgacg 1500
tcataaatag tcgttgtcaa aatgggaggt ggaagtcctt actgtagtca cccgtgaagg 1560
tggagaactg gcaggacatc tctaggtcac ctaaacgtgc gaagtgtgcg aaattaccac 1620
cgtaaattcg tcctactgaa agtgcttacg catcttgaga gagattgcag agagccaggt 1680
caaatacatt gagaaatctg tatatgtact ttggtaacgc tctaaggtag gtacacgtta 1740
gtgatataaa aagaaggcga cgacgaactt aaattgttag agcagtttat gggtggtagg 1800
ttacatctat ttacttcaaa acgcggtgcc ctagcccaca agcattgctt tgtaaaattg 1860
ttgaaggtaa cttgtaaaag ccgaacatga acgatggata gtagaccggg aagaccaacg 1920
ttttttcact actccgaaag aacacactga agggaacggt gtaggttcgg tgagtccggg 1980
actaggtgtc catgtcggag acctcagtgg tgacgtcctc gtagtatag 2029
<210> 116
<211> 552
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 116
gcatactgca agacttgtag gcccatgaat tacccgctta ggcaatgggt agacctttcc 60
ttgccgcgtg gaacaaaccg ccatgagtgt tttacgttta cggtcggcga ccggagtcac 120
agcgcgacca acggggccag gcaaaggccc ataggctttt ccatcggcac gcgaccgatt 180
ccatcaagta tagccacggt cgtaacttcg acggcggcaa tagtttatgg cgctaacacc 240
tttccatcgc tgagtccaaa cgtatgacgt gaggtgttag gtgcaatccc cattcgggac 300
ggacacgcga gtaaaggtct aacatgtttc aactttccag ttagtcgccg tcctatattg 360
gcaagaccgg atggccgtca accagttcca ttctgactat ttgccacatt gattaaagaa 420
gtaggagcgt tagtcggcgc gtgcgcggga ctatttagcg aaggtcgccg tatcgcgggt 480
ggcggcgttt ccgccataac aacaagcgtt taaggtcaga gtccgcgacg aatgaaacgc 540
cgtgcaagcg gc 552
<210> 117
<211> 533
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 117
ggcccatgaa ttacccgctt aggcaatggg tagacctttc cttgccgcgt ggaacaaacc 60
gccatgagtg ttttacgttt acggtcggcg accggagtca cagcgcgacc aacggggcca 120
gggaggaagc cttttagcca tcgctatgcc gccgctcaaa cgcgccgggt gcaaaagccc 180
agagcaaagg cccataggct tttccatcgg cacgcgaccg attccatcaa gtgttaggtg 240
caatccccat tcgggacgga cacgcgagag cgttagtcgg cgcgtgcgcg ggactattta 300
gcgaaggtcg ccgatcgttt gcccgtaaaa ctaactggca aaagcctaag tgctgtttcg 360
ggtgcaatgg tataacttcc cacatttagc cgaatagcgc caacagcgtt attatttgga 420
accaagcagt gggcgatgtc agcgacaatt ccactttggt agaggtcgtt cttttgtaga 480
aaacaatcta acataactat gacactttcg gtaaattcac cacctttacc agg 533
<210> 118
<211> 2085
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 118
gcatactgca agacttgtag gcccatgaat tacccgctta ggcaatgggt agacctttcc 60
ttgccgcgtg gaacaaaccg ccatgagtgt tttacgttta cggtcggcga ccggagtcac 120
agcgcgacca acggggccag gcaaaggccc ataggctttt ccatcggcac gcgaccgatt 180
ccatcaagtg ttaggtgcaa tccccattcg ggacggacac gcgagagcgt tagtcggcgc 240
gtgcgcggga ctatttagcg aaggtcgccg atcgtttgcc cgtaaaacta actggcaaaa 300
gcctaagtgc tgtttcgggt gcaatggtat aacttcccac atttagccga atagcgccaa 360
cagcgttatt atttggaacc aagcagtggg cgatgtcagc gacaattcca ctttggtaga 420
ggtcgttctt ttgtagaaaa caatctaaca taactatgac actttcggta aattcaccac 480
ctttaccagg gtcgtaagtg gtcaagccac gccgaccact tcataagcat tggtggaaat 540
cgcatcgaca caataaaagt acaccaacca gcagaaaaca ggtacatata cagtttaacg 600
acctggatct aagatgacta cagtagcata gccatagaac atggcactga aatatcgatg 660
ggcgtaaaag tgaacaacgc agacgatgga ttacgacgcc aagccactat aaatgctaat 720
tgagtcgaag aaggtactcc tttttggaac acagatattg cagaagcggg aatgaggttg 780
atattacatc aagtatcaac agacgacctc agaagggtgg tcttttaaaa tgacaacgta 840
cattaagatg cagacaaaca ctactatgct ggatgtgaaa atgtcatatg tgcggcaaaa 900
atagacgaca tttaagaacc tagcattata ggatggagtg ttgtattaat tcactctaga 960
gtaatggatc acggtgccag aaactaaggt ggtgtaggac tagatgcaag taacaacggt 1020
cgtactaaaa tcagctacgc gatcgccgac ttagaaggct gagatggaga aacttgtcta 1080
ctggcagacc tcactatctt ttaggaaggt cacgaagcgg ctggagtgat ggctagtctc 1140
agccactgtc aacgggaagc gcgacgttta tggtcaatat aaactagcag tttaatccgt 1200
atggcgatct tagcggatgt tacaggatgg agaagatgac aaagtagaag ctagacaact 1260
atatcaaatc gttgtgtggt cttaaaccga cacagtagca ttcatcgttg gatgtggaag 1320
gtcacagcct cgttggagga gatactacgg tcccgctttt cgtgggtgac aaaggtcgca 1380
aaggtttcct tagggaggtc gtttcccgga tctttatcta catctcctgg gtgaagggga 1440
tgatctttct ctacatgtcc tgggtggagg ggagtttcct tgtatgggtg gaacccaacc 1500
cgccggtgag ggtgagttac ggtcggcggt catatgtggg tatgacgggt atgacgtcat 1560
aaatagtcgt tgtcaaaatg ggaggtggaa gtccttactg tagtcacccg tgaaggtgga 1620
gaactggcag gacatctcta ggtcacctaa acgtgcgaag tgtgcgaaat taccaccgta 1680
aattcgtcct actgaaagtg cttacgcatc ttgagagaga ttgcagagag ccaggtcaaa 1740
tacattgaga aatctgtata tgtactttgg taacgctcta aggtaggtac acgttagtga 1800
tataaaaaga aggcgacgac gaacttaaat tgttagagca gtttatgggt ggtaggttac 1860
atctatttac ttcaaaacgc ggtgccctag cccacaagca ttgctttgta aaattgttga 1920
aggtaacttg taaaagccga acatgaacga tggatagtag accgggaaga ccaacgtttt 1980
ttcactactc cgaaagaaca cactgaaggg aacggtgtag gttcggtgag tccgggacta 2040
ggtgtccatg tcggagacct cagtggtgac gtcctcgtag tatag 2085
<210> 119
<211> 885
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 119
gtatatgtac tttggtaacg ctctaaggta ggtacacgtt agtgatataa aaagaaggcg 60
acgacgaact taaattgtta gagcagttta tgggtggtag gttacatcta tttacttcaa 120
aacgcggtgc cctagcccac aagcattgct ttgtaaaatt gttgaaggta acttgtaaaa 180
gccgaacatg aacgatggat agtagaccgg gaagaccaac gttttttcac tactccgaaa 240
gaacacactg aagggaacgg tgtaggttcg gtgagtccgg gactaggtgt ccatgtcgga 300
gacctcagtg gtgacgtcct cgtagtatag ctgctcgcat gaccagctat atctggaaca 360
tcgctggtgg gtcttatggt cgcttttgtg ggaaccatca tagtcgcaag tctggccttc 420
ggtatggaac tcgtcgtccc gactacaacc atagctagtc tcggtctcgg ctttgttgca 480
atgcccttcg ttactacttc aacggtcgtg gtgccggtca aaccgctcgc taaagcaagc 540
gaagaaacag ctaaacttag ttgtgtcgaa acatcctaag tggtcgggtt gctcgtggag 600
catgcagcta gcccagaacc tttagcttgt gtggtcttcg tctcggtagt cagaaccagg 660
tcggtctgaa tggttggact cgccacatca actaggtcag ctattgaagt gccaactaaa 720
ggtcgtattg aagcaatcgg tcctatggca agtcaagtga cagtcgtagg tatggcactt 780
gccgcgcctc cagaactcgg tcaagctacc tcataactcg gaagtcgact gctctaaagc 840
gaagttgtca aacgaacagc tatgccttcg agtaaagcaa ggtgc 885
<210> 120
<211> 2474
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 120
gcccatgaat tacccgctta ggcaatgggt agacctttcc ttgccgcgtg gaacaaaccg 60
ccatgagtgt tttacgttta cggtcggcga ccggagtcac agcgcgacca acggggccag 120
gcaaaggccc ataggctttt ccatcggcac gcgaccgatt ccatcaagtg ttaggtgcaa 180
tccccattcg ggacggacac gcgagagcgt tagtcggcgc gtgcgcggga ctatttagcg 240
aaggtcgccg atcgtttgcc cgtaaaacta actggcaaaa gcctaagtgc tgtttcgggt 300
gcaatggtat aacttcccac atttagccga atagcgccaa cagcgttatt atttggaacc 360
aagcagtggg cgatgtcagc gacaattcca ctttggtaga ggtcgttctt ttgtagaaaa 420
caatctaaca taactatgac actttcggta aattcaccac ctttaccagg gtcgtaagtg 480
gtcaagccac gccgaccact tcataagcat tggtggaaat cgcatcgaca caataaaagt 540
acaccaacca gcagaaaaca ggtacatata cagtttaacg acctggatct aagatgacta 600
cagtagcata gccatagaac atggcactga aatatcgatg ggcgtaaaag tgaacaacgc 660
agacgatgga ttacgacgcc aagccactat aaatgctaat tgagtcgaag aaggtactcc 720
tttttggaac acagatattg cagaagcggg aatgaggttg atattacatc aagtatcaac 780
agacgacctc agaagggtgg tcttttaaaa tgacaacgta cattaagatg cagacaaaca 840
ctactatgct ggagtgttgt attaattcac tctagagtaa tggatcacgg tgccagaaac 900
taaggtggtg taggactaga tgcaagtaac aacggtcgta ctaaaatcag ctacgcgatc 960
gccgacttag aaggctgaga tggagaaact tgtctactgg cagacctcac tatcttttag 1020
gaaggtcacg aagcggctgg agtgatggct agtctcagcc actgtcaacg ggaagcgcga 1080
cgtttatggt caatataaac tagcagttta atccgtatgg cgatcttagc ggatgttaca 1140
ggatggagaa gatgacaaag tagaagctag acaactatat caaatcgttg tgtggtctta 1200
aaccgacaca gtagcattca tcgttggatg tggaaggtca cagcctcgtt ggaggagata 1260
ctacggtccc gcttttcgtg ggtgacaaag gtcgcaaagg tttccttagg gaggtcgttt 1320
cccggatctt tatctacatc tcctgggtga aggggatgat ctttctctac atagattgca 1380
gagagccagg tcaaatacat tgagaaatct gtatatgtac tttggtaacg ctctaaggta 1440
ggtacacgtt agtgatataa aaagaaggcg acgacgaact taaattgtta gagcagttta 1500
tgggtggtag gttacatcta tttacttcaa aacgcggtgc cctagcccac aagcattgct 1560
ttgtaaaatt gttgaaggta acttgtaaaa gccgaacatg aacgatggat agtagaccgg 1620
gaagaccaac gttttttcac tactccgaaa gaacacactg aagggaacgg tgtaggttcg 1680
gtgagtccgg gactaggtgt ccatgtcgga gacctcagtg gtgacgtcct cgtagtatag 1740
gtccacgctc taagtcgctt gcccaattgt ggctaccgca ttgctcagaa cttcgggtac 1800
tggccaacct tcaagaagcc tagtcttggt gcgtcacccc agtcacgtag catacccgtc 1860
atcatctatg gtcgtaggtc caacaatcgt ggcgccattg ggtaccactt catcagagct 1920
gctcgcatga ccagctatat ctggaacatc gctggtgggt cttatggtcg cttttgtggg 1980
aaccatcata gtcgcaagtc tggccttcgg tatggaactc gtcgtcccga ctacaaccat 2040
agctagtctc ggtctcggct ttgttgcaat gcccttcgtt actacttcaa cggtcgtggt 2100
gccggtcaaa ccgctcgcta aagcaagcga agaaacagct aaacttagtt gtgtcgaaac 2160
atcctaagtg gtcgggttgc tcgtggagca tgcagctagc ccagaacctt tagcttgtgt 2220
ggtcttcgtc tcggtagtca gaaccaggtc ggtctgaatg gttggactcg ccacatcaac 2280
taggtcagct attgaagtgc caactaaagg tcgtattgaa gcaatcggtc ctatggcaag 2340
tcaagtgaca gtcgtaggta tggcacttgc cgcgcctcca gaactcggtc aagctacctc 2400
ataactcgga agtcgactgc tctaaagcga agttgtcaaa cgaacagcta tgccttcgag 2460
taaagcaagg tgcg 2474
<210> 121
<211> 546
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 121
gcatactgca agacttgtag gcccatgaat tacccgctta ggcaatgggt agacctttcc 60
ttgccgcgtg gaacaaaccg ccatgagtgt tttacgttta cggtcggcga ccggagtcac 120
agcgcgacca acgggcaaag gcccataggc ttttccatcg gcacgcgacc gattccatca 180
agtatagcca cggtcgtaac ttcgacggcg gcaatagttt atggcgctaa cacctttcca 240
tcgctgagtc caaacgtatg acgtgaggtg ttaggtgcaa tccccattcg ggacggacac 300
gcgagtaaag gtctaacatg tttcaacttt ccagttagtc gccgtcctat attggcaaga 360
ccggatggcc gtcaaccagt tccattctga ctatttgcca cattgattaa agaagtagga 420
gcgttagtcg gcgcgtgcgc gggactattt agcgaaggtc gccgtatcgc gggtggcggc 480
gtttccgcca taacaacaag cgtttaaggt cagagtccgc gacgaatgaa acgccgtgca 540
agcggc 546
<210> 122
<211> 229
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 122
gtaccaaagc cgcttgcacg gcgtttcatt cgtcgcggac tctgacctta aacgcttgtt 60
gttatggcgg aaacgccgcc acccgcgata cggcgacctt cgctaaatag tcccgcgcac 120
gcgccgacta acgctcctac ttctttaatc aatgtggcaa atagtcagaa tggaactggt 180
tgacggccat ccggtcttgc caatatagga cggcgactaa ctggaaagt 229
<210> 123
<211> 1435
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 123
ggcaagacga atctgcgtca acgctaaagg ccgtcaaaaa gcaagagggc gtcgcgcctg 60
ggaaaaaggt agtcaagaaa ccatcaagct taaatgtcgg gaaattgggt ttgcgccgcc 120
ttcaggggca gcgatggggg cgacaattgt ggaccgtatg gactccatta tgctgggact 180
cctcgggtca accgctctaa agcgaagttg ttggacaaac agttatgcgt aactgtaaag 240
caaggtgccc aaagtagact gagcgacagt cgaaaccagc cccaatgaac aagacgccat 300
tgcaaaacgt ctatacgcta cggtcaaaga cgcttccaca ccacatgttg tgctcgccat 360
ttcaactagt gcagttgcta aagtgccaac taaggttcgt cttgaagcaa tcggtagtat 420
ctgcagtcaa gtcgtagtcg taggtatggc acttgtcgtg cgtctaggac gcgttgaagc 480
tatcttattg cccgaaggag ccgaaagtct gggacacgtc gtgggacgta tcgttaggac 540
tatgggacta gtcgtcttcg gtcttacaaa tgttgcaatg ccctgtgagc tacttatgaa 600
acatgaatgg tcggtcttgt ggtcgctttt gtcgaaatca ccgaagtgcg tataattgat 660
gaacgagtcg aagtcgaagt tgttcaacaa gagagttagg tagtgccgct tgaaaaagta 720
atagtgcaaa taagaaaaag aagcgaaacg gcattcgttt aacaaaacgt cacatattta 780
ggtatagtag attgcgttca caaagaaatt taaatttaat ttaccatttc gtcattgtat 840
atgcggtaaa cgtaaattta cacatatgac acgaactttg agttttatta gcctgcctaa 900
ttgttggtaa caatgtaatg gaaattggcg atgactatgg ggaaagagca atcaactcac 960
cataaatttg tgaacgcagt taagtaattg gcatcgcgcg cctaatcgtt tacattcgca 1020
tggaacaaga agaaagagac ctattcgtgg gagtcaatgg ctatgtggaa aaacatgaac 1080
tgccaaattc ggctaaccaa ccagaaatgg tcatggaaaa ttcttgcgtc aaagttcgcg 1140
gtgacgttta cgaagaagct aaacttgtgc ttgtttagaa agttaggtgc gtcctggttt 1200
tagtaaattt agaaaaccat tttgttgttt gcgacagtta aataaaactt aacgacaaag 1260
aagtgacttg cgtcgtagat taactggaaa ttaaagtggt atctaaaatg gggtttgccg 1320
atgcggtctt caaagtctaa aattcttgaa gtttgcgttt ggtcgcaaaa attatggatt 1380
tagtcgatta ttgcctacta agcagcagtt tagaagtttt taagatagtt acgct 1435
<210> 124
<211> 574
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 124
ggggcagcga tgggggcgac aattgtggac cgtatggact ccattatgct gggactcctc 60
gggtcaaccg ctctaaagcg aagttgttgg acaaacagtt atgcgtaact gtaaagcaag 120
gtgcccaaag tagactgagc gacagtcgaa accagcccca atgaacaaga cgccattgca 180
aaacgtctat acgctacggt caaagacgct tccacaccac atggactatg ggactagtcg 240
tcttcggtct tacaaatgtt gcaatgccct gtgagctact tatgaaacat gaatggtcgg 300
tcttgtggtc gcttttgtcg aaatcaccga agtgcgtata attgatgaac gagtcgaagt 360
cgaagttgtt caacaagaga gttaggtagt gccgcttgaa aaagtaatag tgcaaataag 420
aaaaagaagc gaaacggcat tcgtttaaca aaacgtcaca tatttaggta tagtagattg 480
cgttcacaaa gaaatttaaa tttaatttac catttcgtca ttgtatatgc ggtaaacgta 540
aatttacaca tatgacacga actttgagtt ttat 574
<210> 125
<211> 1969
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 125
gtgggtttat atcgcgtatc catccaactt aactgaaacg cgaagcagta gacagtgttg 60
atcgagattt gcgaagggaa acagtaaaag tccagggtgt cgttaattac gacaaaacta 120
aagactgtat agttagaagg atcaattggg ctgatttaga aatggtataa gttaaagaaa 180
tggaaactta ttcgacaaaa agaaaaactc atgatgtata gatggaaact gccataatgt 240
cgattcgagt tatattttta gattttggta aaatatccaa catgtattaa cgaaattttg 300
aagtatagat caaactattc ttcaggtaca gcatcaagca ttcggtagca taagccaaac 360
aagtctttga agggttggac atagcgagtt gtgtagaaag ttacgaagac ttcaacagaa 420
aaagagttta aaaggaccac gtatgccaaa tcgacaacaa tatagtcgtt ctattctgcg 480
atatgtaaga tagagacaca tcggcaggta gcatagaact tgggtcaatt attatttaag 540
tgcggtaaca aacaaactta gggaatatta ttgtgctaca gcaaatgcct tgaaaagtcg 600
agaaagacta ctatactcgt caagttcgta aagacttaac agtaattgta atgcaaatac 660
ttagcgagat tgattccttc ccagtagtca tctttccttt agatattaga acagcaattt 720
tagattttgt acatagtgga gaaaaggacg tcattttaat ggatgaacca gacgttaacg 780
tcatttactt ggtcgttgat ttcgaagact cagtcatcaa aattgtagct tcgctagcta 840
atgtgcttaa aatcatcata gtcaaagtgt acgtggtcgt ggtaataaac aaccttcatt 900
actgtacaaa agtgccagtt tgttacatta tcgaacgctg tatagaggta tcatttcacc 960
tatttgacaa ctaggtgata aaccttcggt cgctagacgt tgttgttatt gaaaaaatgg 1020
aagataatct atacttaatc caaaacaacc cagaccaagc tcgtatataa atggaagtcg 1080
tcaaaattgg tttcgttcaa ataagttggg actgatgaat cagttttctg aacttcaccg 1140
ctattagcgt cctagttgtc tacataatta gtatcattat tgtagtagtt taaatcgcta 1200
acaaccaaaa aatccttgac atgggtaacg acgttattgg ggaaccaatg ctcagtgttg 1260
gtgaaagaat cgttaggtcg aactattggt acgttctaat aaaagacgac atagaaattc 1320
gttacataat caacgtcact actaagggcg tattgcaaat tagttcataa attattaaca 1380
gtttgcacct aatagttcta gtccttaaaa aggtagaaga cgtaggtaat gtcagttgcc 1440
tcaatgtagt caggtaaaaa gtatatgtgc tgatggcaaa cttcatcttt gtgagagttg 1500
agcatgtata acaacatcac tcagtataac cgcttggtta cacaattagt atcatgccta 1560
tagaacgcct tatcattcag gtcgtcgtga tagtgaaggg gatcaaagtc aaaatctact 1620
ttgtcataac tctttacggt atcccaatgc ttggtataag tgcttaagaa attgtttaaa 1680
cagaaactca agtataagcg aaaacaagtt acctggaaaa agaagaagtg cgtataattg 1740
atgaacgagt cgaagtcgaa gttgttcaac aagagagtta ggtagtgccg cttgaaaaag 1800
taatagtgca aataagaaag taagactgta tcggagacga ctttttaata gtagtaattc 1860
tcggtacaac taaaccagta atttcagaca ctgaaataga ggacttcgtt aggtacgaag 1920
caagttaact aaatgacaat taaattgagg gtaaatatca caaagaaat 1969
<210> 126
<211> 1537
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 126
gcttaaatgt cgggaaattg ggtttgcgcc gccttcaggg gcagcgatgg gggcgacaat 60
tgtggaccgt atggactcca ttatgctggg actcctcggg tcaaccgctc taaagcgaag 120
ttgttggaca aacagttatg cgtaactgta aagcaaggtg cccaaagtag actgagcgac 180
agtcgaaacc agccccaatg aacaagacgc cattgcaaaa cgtctatacg ctacggtcaa 240
agacgcttcc acaccacatg ctctcatgta gcctacctta cgaagaaatc gcacaagtcg 300
gtcgcccagc ggtggcatat gtcttgccta acgtttctag accgatcagc ctcacgagta 360
gcctgcttgt ggtgtttata gtttacgcta gtccaatctg tatcgtgccg cttggtatgg 420
ctattgtcgg cctggatgca attgtgctcg ccatttcaac tagtgcagtt gctaaagtgc 480
caactaaggt tcgtcttgaa gcaatcggta gtatctgcag tcaagtcgta gtcgtaggta 540
tggcacttgt cgtgcgtcta ggacgcgttg aagctatctt attgcccgaa ggagccgaaa 600
gtctgggaca cgtcgtggga cgtatcgtta ggactatggg actagtcgtc ttcggtctta 660
caaatgttgc aatgccctgt gagctactta tgaaacatga atggtcggtc ttgtggtcgc 720
ttttgtcgaa atcaccgaag tgcgtataat tgatgaacga gtcgaagtcg aagttgttca 780
acaagagagt taggtagtgc cgcttgaaaa agtaatagtg caaataagaa aaagcgaaac 840
ggcattcgtt taacaaaacg tcacatattt aggtatagta gattgcgttc acaaagaaat 900
ttaaatttaa tttaccattt cgtcattgta tatgcggtaa acgtaaattt acacatatga 960
cacgaacttt gagttttatt agcctgccta attgttggta acaatgtaat ggaaattggc 1020
gatgactatg gggaaagagc aatcaactca ccataaattt gtgaacgcag ttaagtaatt 1080
ggcatcgcgc gcctaatcgt ttacattcgc atggaacaag aagaaagaga cctattcgtg 1140
ggagtcaatg gctatgtgga aaaacatgaa ctgccaaatt cggctaacca accagaaatg 1200
gtcatggaaa attcttgcgt caaagttcgc ggtgacgttt acgaagaagc taaacttgtg 1260
cttgtttaga aagttaggtg cgtcctggtt ttagtaaatt tagaaaacca ttttgttgtt 1320
tgcgacagtt aaataaaact taacgacaaa gaagtgactt gcgtcgtaga ttaactggaa 1380
attaaagtgg tatctaaaat ggggtttgcc gatgcggtct tcaaagtcta aaattcttga 1440
agtttgcgtt tggtcgcaaa aattatggat ttagtcgatt attgcctact aagcagcagt 1500
ttagaagttt ttaagatagt tacgctagaa gaccggg 1537
<210> 127
<211> 1088
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 127
gcgatggggg cgacaattgt ggaccgtatg gactccatta tgctgggact cctcgggtca 60
accgctctaa agcgaagttg ttggacaaac agttatgcgt aactgtaaag caaggtgccc 120
aaagtagact gagcgacagt cgaaaccagc cccaatgaac aagacgccat tgcaaaacgt 180
ctatacgcta cggtcaaaga cgcttccaca ccacatgctc tcatgtagcc taccttacga 240
agaaatcgca caagtcggtc gcccagcggt ggcatatgtc ttgcctaacg tttctagacc 300
gatcagcctc acgagtagcc tgcttgtggt gtttatagtt tacgctagtc caatctgtat 360
cgtgccgctt ggtatggcta ttgtcggcct ggatgcaatt gtgctcgcca tttcaactag 420
tgcagttgct aaagtgccaa ctaaggttcg tcttgaagca atcggtagta tctgcagtca 480
agtcgtagtc gtaggtatgg cacttgtcgt gcgtctagga cgcgttgaag ctatcttatt 540
gcccgaagga gccgaaagtc tgggacacgt cgtgggacgt atcgttagga ctatgggact 600
agtcgtcttc ggtcttacaa atgttgcaat gccctgtgag ctacttatga aacatgaatg 660
gtcggtcttg tggtcgcttt tgtcgaaatc accgaagtgc gtataattga tgaacgagtc 720
gaagtcgaag ttgttcaaca agagagttag gtagtgccgc ttgaaaaagt aatagtgcaa 780
ataagaaaaa gaagcgaaac ggcattcgtt taacaaaacg tcacatattt aggtatagta 840
gattgcgttc acaaagaaat ttaaagtctt gtaattatgg tggtcgattt attggtagta 900
tatttggaaa tagcatgcaa ttttggaatg gacgaagaac ctgacatctg agctattgta 960
agtttaattt accatttcgt cattgtatat gcggtaaacg taaatttaca catatgacac 1020
gaactttgag ttttattagc ctgcctaatt gttggtaaca atgtaatgga aattggcgat 1080
gactatgg 1088
<210> 128
<211> 545
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 128
gaatattgtt tcaatggtcg tggcgctggt cagactgctc gctaaagtcg tcgaagaaac 60
agctagacca tctattctct gaacttccta agtggtcggg ttggtcgtgg cgctcatagt 120
tagcccagaa cgtccagttt atgtggtggt gatcttggtt gccagactca gtatggtcaa 180
aatagttgtg ctcgccattt caactagtgc agttgctaaa gtgccaacta aggttcgtct 240
tgaagcaatc ggtagtatct gcagtcaagt cgtagtcgta ggtatggcac ttgtcgtgcg 300
tctaggacgc gttgaagcta tcttattgcc cgaaggagcc gaaagtctgg gacacgtcgt 360
gggacgtatc gttaggacta tgggactagt cgtcttcggt cttacaaatg ttgcaatgcc 420
ctgtgagcta cttatgaaac atgaatggtc ggtcttgtgg tcgcttttgt cgaaatcacc 480
gaagtgcgta taattgatga acgagtcgaa gtcgaagttg ttcaacaaga gagttaggta 540
gtgcc 545
<210> 129
<211> 574
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 129
gcgatggggg cgacaattgt ggaccgtatg gactccatta tgctgggact cctcgggtca 60
accgctctaa agcgaagttg ttggacaaac agttatgcgt aactgtaaag caaggtgccc 120
aagtagactc ttactaattt gggaacgacg gaaagtcgct accttcatcg gtatggcttt 180
cgctaaagtc ggtcaaatgg aagaaggtag tcgaagtact gttgaaagag tagactgagc 240
gacagtcgaa accagcccca atgaacaaga cgccattgca aaacgtctat acgctacggt 300
caaagacgct tccacaccac atgctctcat gtagcctacc ttacgaagaa atcgcacaag 360
tcggtcgccc agcggtggca tatgtcttgc ctaacgtttc tagaccgatc agcctcacga 420
gtagcctgct tgtggtgttt atagtttacg ctagtccaat ctgtatcgtg ccgcttggta 480
tggctattgt cggcctggat gcaattgtgc tcgccatttc aactagtgca gttgctaaag 540
tgccaactaa ggttcgtctt gaagcaatcg gtag 574
<210> 130
<211> 377
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 130
gcctatgcct cgtatcatct atggtcgtag gtaaagcaat agcggaaaca ttggatgtga 60
cttcatcagg actgctcgta tagtgagcta cttatgaaac atgaatggtc ggtcttgtgg 120
tcgcttttgt cgaaatcacc gaagtgcgta taattgatga acgagtcgaa gtcgaagttg 180
ttcaacaaga gagttaggta gtgccgcttg aaaaagtaat agtgcaaata agaaaaagaa 240
gcgaaacggc attcgtttaa caaaacgtca catatttagg tatagtagat tgcgttcaca 300
aagaaattta aatttaattt accatttcgt cattgtatat gcggtaaacg taaatttaca 360
catatgacac gaacttt 377
<210> 131
<211> 485
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 131
gggcgacaat tgtggaccgt atggactcca ttatgctggg actcctcggg tcaaccgctc 60
taaagcgaag ttgttggaca aacagttatg cgtaactgta aagcaaggtg cccaaagtag 120
actgagcgac agtcgaaacc agccccaatg aacaagacgc cattgcaaaa cgtctatacg 180
ctacggtcaa agacgcttcc acaccacatg ctctcatgta gcctacctta cgaagaaatc 240
gcacaagtcg gtcgcccagc ggtggcatat gtcttgccta acgtttctag accgatcagc 300
ctcacgagta gcctgcttgt ggtgtttata gtttacgcta gtccaatctg tatcgtgccg 360
cttggtatgg ctattgtcgg cctggatgca agcactaacg tggtcatcag actggtctgc 420
gctataatct acgcaataga ggcaccagcg gtcgttgaag ccgaagacgc tatttcggtg 480
gcttg 485
<210> 132
<211> 1163
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 132
gtgctcgcca tttcaactag tgcagttgct aaagtgccaa ctaaggttcg tcttgaagca 60
atcggtagta tctgcagtca agtcgtagtc gtaggtatgg cacttgtcgt gcgtctagga 120
cgcgttgaag ctatcttatt gcccgaagga gccgaaagtc tgggacacgt cgtgggacgt 180
atcgttagga ctatgggact agtcgtcttc ggtcttacaa atgttgcaat gccctgtgag 240
ctacttatga aacatgaatg gtcggtcttg tggtcgcttt tgtcgaaatc accgaagtgc 300
gtataattga tgaacgagtc gaagtcgaag ttgttcaaca agagagttag gtagtgccgc 360
ttgaaaaagt aatagtgcaa ataagaaagt aagactgtat cggagacgac tttttaatag 420
tagtaattct cggtacaact aaaccagtaa tttcagacac tgaaatagag gacttcgtta 480
ggtacgaagc aagttaacta aatgacaatt aaattgaggg taaatatcac aaagaaatca 540
tggaagattt cgaccgaata caggaaaatt tagattaaag gtttgtcgtc gttgaaataa 600
gaagaagcga aacggcattc gtttaacaaa acgtcacata tttaggtata gtagattgcg 660
ttcacaaaga aatttaaatt taatttacca tttcgtcatt gtatatgcgg taaacgtaaa 720
tttacacata tgacacgaac tttgagtttt attagcctgc ctaattgttg gtaacaatgt 780
aatggaaatt ggcgatgact atggggaaag agcaatcaac tcaccataaa tttgtgaacg 840
cagttaagta attggcatcg cgcgcctaat cgtttacatt cgcatggaac aagaagaaag 900
agacctattc gtgggagtca atggctatgt ggaaaaacat gaactgccaa attcggctaa 960
ccaaccagaa atggtcatgg aaaattcttg cgtcaaagtt cgcggtgacg tttacgaaga 1020
agctaaactt gtgcttgttt agaaagttag gtgcgtcctg gttttagtaa atttagaaaa 1080
ccattttgtt gtttgcgaca gttaaataaa acttaacgac aaagaagtga cttgcgtcgt 1140
agattaactg gaaattaaag tgg 1163
<210> 133
<211> 454
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 133
ggtagttgtt gaaaaagtag gaatatctag cctagatgtc gtttcaggcg aaggactcta 60
aggtcttaaa atcgttgggt caaccgctct aaagcgaagt tgttggacaa acagttatgc 120
gtaactgtaa agcaaggtgc ccaaagtaga ctgagcgaca gtcgaaacca gccccaatga 180
acaagacgcc attgcaaaac gtctatacgc tacggtcaaa gacgcttcca caccacatgg 240
tatagtggac gccgttagcc tcatgtgtct cactcaaaga ccttgcgtca cggtcatcct 300
ctttgtcagc aacgtagaaa tctccggtct gtcgatacct tgcgtaaagc tctcatgtag 360
cctaccttac gaagaaatcg cacaagtcgg tcgcccagcg gtggcatatg tcttgcctaa 420
cgtttctaga ccgatcagcc tcacgagtag cctg 454
<210> 134
<211> 1528
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 134
gcttaaatgt cgggaaattg ggtttgcgcc gccttcaggg gcagcgatgg gggcgacaat 60
tgtggaccgt atggactcca ttatgctggg actcctcggg tcaaccgctc taaagcgaag 120
ttgttggaca aacagttatg cgtaactgta aagcaaggtg cccaaagtag actgagcgac 180
agtcgaaacc agccccaatg aacaagacgc cattgcaaaa cgtctatacg ctacggtcaa 240
agacgcttcc acaccacatg ctctcatgta gcctacctta cgaagaaatc gcacaagtcg 300
gtcgcccagc ggtggcatat gtcttgccta acgtttctag accgatcagc ctcacgagta 360
gcctgcttgt ggtgtttata gtttacgcta gtccaatctg tatcgtgccg cttggtatgg 420
ctattgtcgg cctggatgca attgtgctcg ccatttcaac tagtgcagtt gctaaagtgc 480
caactaaggt tcgtcttgaa gcaatcggta gtatctgcag tcaagtcgta gtcgtaggta 540
tggcacttgt cgtgcgtcta ggacgcgttg aagctatctt attgcccgaa ggagccgaaa 600
gtctgggaca cgtcgtggga cgtatcgtta ggactatggg actagtcgtc ttcggtctta 660
caaatgttgc aatgccctgt gagctactta tgaaacatga atggtcggtc ttgtggtcgc 720
ttttgtcgaa atcaccgaag tgcgtataat tgatgaacga gtcgaagtcg aagttgttca 780
acaagagagt taggtagtgc cgcttgaaaa agtaatagtg caaataagaa aaagaagcga 840
aacggcattc gtttaacaaa acgtcacata tttaggtata gtagattgcg ttcacaaaga 900
aatttaaatt taatttacca tttcgtcatt gtatatgcgg taaacgtaaa tttacacata 960
tgacacgaac tttgagtttt attagcctgc ctaattgttg gtaacaatgt aatggaaatt 1020
ggcgatgact atggggaaag agcaatcaac tcaccataaa tttgtgaacg cagttaagta 1080
attggcatcg cgcgcctaat cgtttacatt cgcatggaac aagaagaaag agacctattc 1140
gtgggagtca atggctatgt ggaaaaacat gaactgccaa attcggctaa ccaaccagaa 1200
atggtcatgg aaaattcttg cgtcaaagtt cgcggtgacg tttacgaaga agctaaactt 1260
gtgcttgttt agaaagttag gtgcgtcctg gttttagtaa atttagaaaa ccattttgtt 1320
gtttgcgaca gttaaataaa acttaacgac aaagaagtga cttgcgtcgt agattaactg 1380
gaaattaaag tggtatctaa aatggggttt gccgatgcgg tcttcaaagt ctaaaattct 1440
tgaagtttgc gtttggtcgc aaaaattatg gatttagtcg attattgcct actaagcagc 1500
agtttagaag tttttaagat agttacgc 1528
<210> 135
<211> 1311
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 135
gtgagctact tatgaaacat gaatggtcgg tcttgtggtc gcttttgtcg aaatcaccgg 60
aaacattaaa tcaaagaagt ttatcaacca attagtacag tggcatgtta agtaaaacag 120
aaagaacgcc aagtggcaac aaatgacgta attatttaag caaaaagcgt aaacgcttac 180
aaaggctatt taaatatcag taaatcgttg gaaattgggt atgtgctgcc ttcatacgca 240
aaaatggatg cgacagaaac gagttgtatg gcctccacta cgctcgcctg ccgcggaccc 300
taaacgacag tcgtttgccc aactacggct acggcatcgc tcagaacttc gggtcttggc 360
ccacctttct gacgcctagt caacgtgcgt cgcctcagtc ttggacaaaa agaagaaata 420
tcaattgcaa aaataactat aggtacttct ttgaagaaac caaacgtgag tttctaacac 480
gactaaatcc atttgatctt tgagaaagtc gaagacgaat gaagtgcgta taattgatga 540
acgagtcgaa gtcgaagttg ttcaacaaga gagttaggta gtgccgcttg aaaaagtaat 600
agtgcaaata agaaaaagaa gcgaaacggc attcgtttaa caaaacgtca catatttagg 660
tatagtagat tgcgttcaca aagaaattta aatttaattt accatttcgt cattgtatat 720
gcggtaaacg taaatttaca catatgacac gaactttgag ttttattagc ctgcctaatt 780
gttggtaaca atgtaatgga aattggcgat gactatgggg aaagagcaat caactcacca 840
taaatttgtg aacgcagtta agtaattggc atcgcgcgcc taatcgttta cattcgcatg 900
gaacaagaag aaagagacct attcgtggga gtcaatggct atgtggaaaa acatgaactg 960
ccaaattcgg ctaaccaacc agaaatggtc atggaaaatt cttgcgtcaa agttcgcggt 1020
gacgtttacg aagaagctaa acttgtgctt gtttagaaag ttaggtgcgt cctggtttta 1080
gtaaatttag aaaaccattt tgttgtttgc gacagttaaa taaaacttaa cgacaaagaa 1140
gtgacttgcg tcgtagatta actggaaatt aaagtggtat ctaaaatggg gtttgccgat 1200
gcggtcttca aagtctaaaa ttcttgaagt ttgcgtttgg tcgcaaaaat tatggattta 1260
gtcgattatt gcctactaag cagcagttta gaagttttta agatagttac g 1311
<210> 136
<211> 459
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 136
ggttcgtctt gaagcaatcg gtagtatctg cagtcaagtc gtagtcgtag gtatggcact 60
tgtcgtgcgt ctaggacgcg ttgaagctat cttattgccc gaaggagccg aaagtctggg 120
acacgtcgtg ggacgtatcg ttaggactat gggactagtc gtcttcggtc ttacaaatgt 180
tgcaatgccc tgtgagctac ttatgaaaca tgaatggtcg gtcttgtggt cgcttttgtc 240
gaaatcaccg gacaaaaaga agaaatatca attgcaaaaa taactatagg tacttctttg 300
aagaaaccaa acgtgagttt ctaacacgac taaatccatt tgatctttga gaaagtcgaa 360
gacgaatgaa gtgcgtataa ttgatgaacg agtcgaagtc gaagttgttc aacaagagag 420
ttaggtagtg ccgcttgaaa aagtaatagt gcaaataag 459
<210> 137
<211> 783
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 137
ggggaaccaa tgctcagtgt tggtgaaaga atcgttaggt cgaactattg gtacgttcta 60
ataaaagacg acatagaaat tcgttacata atcaacgtca ctactaaggg cgtattgcaa 120
attagttcat aaattattaa cagtttgcac ctaatagttc tagtccttaa aaaggtagaa 180
gacgtaggta atgtcagttg cctcaatgta gtcaggtaaa aagtatatgt gctgatggca 240
aacttcatct ttgtgagagt tgagcatgta taacaacatc actcagtata accgcttggt 300
tacacaatta gtatcatgcc tatagaacgc cttatcattc aggtcgtcgt gatagtgaag 360
gggatcaaag tcaaaatcta ctttgtcata actctttacg gtatcccaat gcttggtata 420
agtgcttaag aaattgttta aacagaaact caagtataag cgaaaacaag ttacctggaa 480
aaagaagaag tgcgtataat tgatgaacga gtcgaagtcg aagttgttca acaagagagt 540
taggtagtgc cgcttgaaaa agtaatagtg caaataagaa aaagaagcga aacggcattc 600
gtttaacaaa acgtcacata tttaggtata gtagattgcg ttcacaaaga aatttaaatt 660
taatttacca tttcgtcatt gtatatgcgg taaacgtaaa tttacacata tgacacgaac 720
tttgagtttt attagcctgc ctaattgttg gtaacaatgt aatggaaatt ggcgatgact 780
atg 783
<210> 138
<211> 531
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 138
gaatattgtt tcaatggtcg tggcgctggt cagactgctc gctaaagtcg tcgaagaaac 60
agctagacca tctattctct gaacttccta agtggtcggg ttggtcgtgg cgctcatagt 120
tagcccagaa cgtccagttt atgtggtggt gatcttggtt gccagactca gtatggtcaa 180
aatagttgtg ctcgccattt caactagtgc agttgctaaa gtgccaacta aggttcgtct 240
tgaagcaatc ggtagtatct gcagtcaagt cgtagtcgta ggtatggcac ttgtcgtgcg 300
tctaggacgc gttgaagcta tcttattgcc cgaaggagcc gaaagtctgg gacacgtcgt 360
gggacgtatc gttaggacta tgggactagt cgtcttcggt cttacaaatt gagctactta 420
tgaaacatga atggtcggtc ttgtggtcgc ttttgtcgaa atcaccgaag tgcgtataat 480
tgatgaacga gtcgaagtcg aagttgttca acaagagagt taggtagtgc c 531
<210> 139
<211> 276
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 139
gagatttcta cgttgctgac aaagaggatg accgtgacgc aaggtctttg agtgagacac 60
atgaggctaa cggcgtccac tataccatgt ggtgtggaag cgtctttgac cgtagcgtat 120
agacgttttg caatggcgtc ttgttcattg gggctggttt cgactgtcgc tcagtctact 180
ctttcaacag tacttcgact accttcttcc atttgaccga ctttagcgaa agccataccg 240
atgaaggtag cgactttccg tcgttcccaa attagt 276
<210> 140
<211> 189
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 140
gcagatacta ccgattgctt caagacgaac cttagttggc actttagcaa ctgcactagt 60
tgaaatggcg agcacaacta ttttgaccat actgagtctg gcaaccaaga tcaccaccac 120
ataaactgga cgttctgggc taactatgag cgccacgacc aacccgacca cttaggaagt 180
tcagagaat 189
<210> 141
<211> 2462
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 141
gagacgatga aacttgagaa atcgcactgg cttacatata cacgataaaa gactttaata 60
caatataaga agtcgttatt gaagacggag atgtatgtta ccgcccaatt ttagagatac 120
aaaatgagac tgacatagcg gttaactata ttagagcacg cctaagcatt gaaggtttag 180
tcatcttcat tagagtatac tgtattgacg gctgaatgca aataaattga gacaaaaccg 240
atttcttgaa ttagcacgaa gtaagtataa aactagtaga gtgacaccaa gtatataggg 300
ggtttatatc gcgtggaatc gaacaacata tctatttaat tagtttaata acaaattaag 360
tgacttatcg cggaagagag aacaatagat tggattaaaa agttgtagta aaccacaacg 420
aagttaggta gctggtaagg ttatagatgc gttctgtcgt tgtagtccca atgaacatag 480
tatggtttcg catagtaact gacctaaaag accgccacat agtgaaaata cttaaaacgc 540
aagtttcata ggattaagtg gtagaggcta tagaaaatga tatcataact ataacgaata 600
taacagcaaa ttaaaatgca ctggaagtgg aaaatttcag caagagagtc gaagtcgtca 660
tagattagca tggataatgg caattatagt taaaatagtc gtaaattaga ttatggtgca 720
ccggggtgta agtttcgaac tcggtgaggc aatagtagta tagactaaca acaaggtaga 780
cattgcaatg tattgcgaga agaacttcac gaagatatag atacagtaca gaatttctag 840
gattaagtac agcagacgta tttacacctg ttataggata cttgttcact taatccctgt 900
tatgacaaag tagtctcata gaatttttag aacgagaaga tttgaatgga cgtaaaggaa 960
gaaggtcaaa atggagaact taaaagggga aatctagaac attgaaccca acattataca 1020
atgatataag aacgaaaaga cgaagacaat aaggtccatg ggatttaccc aaatgaggac 1080
ctaaatcacc gggaagaagt aagtaaacat aacgatatag ttttagatta tcgagaagtc 1140
gaagaagacc gggataggta acagataatc gacgtttggg aagacggtaa cgtaagaaac 1200
tgaggaggtt aaagaactaa gaatcaacaa caagaaacta ttgtccctat tctacttagg 1260
tatctgctag tatgcgatat ggaagttaaa gaggaaacag tagtatgcac tgtttgagaa 1320
aattaggatt taagaggtgg agaagtcgtt agtttggaag catagatagt tcaaatatcc 1380
acagaaggct attaaaagat agaagagagt cgagagatcg attttaaagt ctgagtcgaa 1440
atagtttggt gcaagattat ccattcaatt cttatcgaaa acttacaagg tcaacaagta 1500
gagatagcaa tataactaaa agctatctat tgaacataaa tgcgcgacta cagcttgcgg 1560
gttaacacgg tcgtcttcat tatacgttta atcgacgccg gcttattcat gcagatattt 1620
aactcaatct tcgataggat agaggacgta gtagacttgg atgtctgtca tccagacatg 1680
agacatatac ttatatggat aatggtagtg cagcaaagtc gtataattta aacggtatgg 1740
gacgaagcta acaacataga ggtggacaac gtatagcagg taattgttaa acttgttctg 1800
gaaataaaga aagaaatctt ttggactatg ggcgtggcat tagtatcaag agtagtcttg 1860
gtttgtatta tattggcagt gagcttattc gtaatagacg taatctgtcg cacttacgtt 1920
tagccaaatt aggtccgtga aacagacaca aacctatatt tatgtggcca cggacaaacg 1980
aaaactataa gctacttcgc attctgaggt cttgttgggc taataataga ctgcaatcac 2040
gttgctgggg tggtatcctt aactaacaat atggtaagta cggtgatagt gacattcaaa 2100
atagggtggt aacttagcat ggtctacttg gtggcagaag tggaagtggt agttatattc 2160
agctttatgg ttttacactg tatatttcac ttggcggtcg ccacaataaa gatttagaat 2220
ccactggcag aaagtcagcg catttttata gcagacaact tgcaaaggga gaggttcatg 2280
caacgtgtta tggtggatca agttatctta gtaagacata aacttgtata gacaataaca 2340
gtggcggaaa ttaaggttaa gataattgta actatagttc cgggagagaa ctatttaatt 2400
ccgacaactg ttatagccaa aatagatgaa atagagcgta taaaacctat tcttccaagc 2460
gt 2462
<210> 142
<211> 2247
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 142
gattggatta aaaagttgta gtaaaccaca acgaagttag gtagctggta aggttataga 60
tgcgttctgt cgttgtagtc ccaatgaaca tagtatggtt tcgcatagta actgacctaa 120
aagaccgcca catagtgaaa atacttaaaa cgcaagtttc ataggattaa gtggtagagg 180
ctatagaaaa tgatatcata actataacga atataacagc aaattaaaat gcactggaag 240
tggaaaattt cagcaagaga gtcgaagtcg tcatagatta gcatggacga aagaaaagtc 300
gcaaagatcg gaaatcaaga cgcaaaacaa aacggagaag ttcaaatcga actcgtagaa 360
catatcgctg gaacatatta aactcttggt atcgctcagt tacaaaagga gacacgtaga 420
cacgaaagaa actggaacaa cagacatatt tgtggataat ggcaattata gttaaaatag 480
tcgtaaatta gattatggtg caccggggtg taagtttcga actcggtgag gcaatagtag 540
tatagactaa caacaaggta gacattgcaa tgtattgcga gaagaacttc acgaagatat 600
agatacagta cagaatttct aggattaagt acagcagacg tatttacacc tgttatagga 660
tacttgttca cttaatccct gttatgacaa agtagtctca tagaattttt agaacgagaa 720
gatttgaatg gacgtaaagg aagaaggtca aaatggagaa cttaaaaggg gaaatctaga 780
acattgaacc caacattata caatgatata agaacgaaaa gacgaagaca ataaggtcca 840
tgggatttac ccaaatgagg acctaaatca ccgggaagaa gtaagtaaac ataacgatat 900
agttttagat tatcgagaag tcgaagaaga ccgggatagg taacagataa tcgacgtttg 960
ggaagacggt aacgtaagaa actgaggagg ttaaagaact aagaatcaac aacaagaaac 1020
tattgtccct attctactta ggtatctgct agtatgcgat atggaagtta aagaggaaac 1080
agtagtatgc actgtttgag aaaattagga tttaagaggt ggagaagtcg ttagtttgga 1140
agcatagata gttcaaatat ccacagaagg ctattaaaag atagaagaga gtcgagagat 1200
cgattttaaa gtctgagtcg aaatagtttg gtgcaagatt atccattcaa ttcttatcga 1260
aaacttacaa ggtcaacaag tagagatagc aatataacta aaagctatct attgaacata 1320
aatgcgcgac tacagcttgc gggttaacac ggtcgtcttc attatacgtt taatcgacgc 1380
cggcttattc atgcagatat ttaactcaat cttcgatagg atagaggacg tagtagactt 1440
ggatgtctgt catccagaca tgagacatat acttatatgg ataatggtag tgcagcaaag 1500
tcgtataatt taaacggtat gggacgaagc taacaacata gaggtggaca acgtatagca 1560
ggtaattgtt aaacttgttc tggaaataaa gaaagaaatc ttttggacta tgggcgtggc 1620
attagtatca agagtagtct tggtttgtat tatattggca gtgagcttat tcgtaataga 1680
cgtaatctgt cgcacttacg tttagccaaa ttaggtccgt gaaacagaca caaacctata 1740
tttatgtggc cacggacaaa cgaaaactat aagctacttc gcattctgag gtcttgttgg 1800
gctaataata gactgcaatc acgttgctgg ggtggtatcc ttaactaaca atatggtaag 1860
tacggtgata gtgacattca aaatagggtg gtaacttagc atggtctact tggtggcaga 1920
agtggaagtg gtagttatat tcagctttat ggttttacac tgtatatttc acttggcggt 1980
cgccacaata aagatttaga atccactggc agaaagtcag cgcattttta tagcagacaa 2040
cttgcaaagg gagaggttca tgcaacgtgt tatggtggat caagttatct tagtaagaca 2100
taaacttgta tagacaataa cagtggcgga aattaaggtt aagataattg taactatagt 2160
tccgggagag aactatttaa ttccgacaac tgttatagcc aaaatagatg aaatagagcg 2220
tataaaacct attcttccaa gcgtaat 2247
<210> 143
<211> 2498
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 143
gatgaaactt gagaaatcgc actggcttac atatacacga taaaagactt taatacaata 60
taagaagtcg ttattgaaga cggagatgta tgttaccgcc caattttaga gatacaaaat 120
gagactgaca tagcggttaa ctatattaga gcacgcctaa gcattgaagg tttagtcatc 180
ttcattagag tatactgtat tgacggctga atgcaaataa attgagacaa aaccgatttc 240
ttgaattagc acgaagtaag tataaaacta gtagagtgac accaagtata tagggggttt 300
atatcgcgtg gaatcgaaca acatatctat ttaattagtt taataacaaa ttaagtgact 360
tatcgcggaa gagagaacaa tagattggat taaaaagttg tagtaaacca caacgaagtt 420
aggtagctgg taaggttata gatgcgttct gtcgttgtag tcccaatgaa catagtatgg 480
tttcgcatag taactgacct aaaagaccgc cacatagtga aaatacttaa aacgcaagtt 540
tcataggatt aagtggtaga ggctatagaa aatgatatca taactataac gaatataaca 600
gcaaattaaa atgcactgga tgttagagca aattatataa actttcacat gctaaccaac 660
gtaatttgag aagaaatcat caagaattaa actaaaggaa tggtggataa tggcaattat 720
agttaaaata gtcgtaaatt agattatggt gcaccggggt gtaagtttcg aactcggtga 780
ggcaatagta gtatagacta acaacaaggt agacattgca atgtattgcg agaagaactt 840
cacgaagata tagatacagt acagaatttc taggattaag tacagcagac gtatttacac 900
ctgttatagg atacttgttc acttaatccc tgttatgaca aagtagtctc atagaatttt 960
tagaacgaga agatttgaat ggacgtaaag gaagaaggtc aaaatggaga acttaaaagg 1020
ggaaatctag aacattgaac ccaacattat acaatgatat aagaacgaaa agacgaagac 1080
aataaggtcc atgggattta cccaaatgag gacctaaatc accgggaaga agtaagtaaa 1140
cataacgata tagttttaga ttatcgagaa gtcgaagaag accgggatag gtaacagata 1200
atcgacgttt gggaagacgg taacgtaaga aactgaggag gttaaagaac taagaatcaa 1260
caacaagaaa ctattgtccc tattctactt aggtatctgc tagtatgcga tatggaagtt 1320
aaagaggaaa cagtagtatg cactgtttga gaaaattagg atttaagagg tggagaagtc 1380
gttagtttgg aagcatagat agttcaaata tccacagaag gctattaaaa gatagaagag 1440
agtcgagaga tcgattttaa agtctgagtc gaaatagttt ggtgcaagat tatccattca 1500
attcttatcg aaaacttaca aggtcaacaa gtagagatag caatataact aaaagctatc 1560
tattgaacat aaatgcgcga ctacagcttg cgggttaaca cggtcgtctt cattatacgt 1620
ttaatcgacg ccggcttatt catgcagata tttaactcaa tcttcgatag gatagaggac 1680
gtagtagact tggatgtctg tcatccagac atgagacata tacttatatg gataatggta 1740
gtgcagcaaa gtcgtataat ttaaacggta tgggacgaag ctaacaacat agaggtggac 1800
aacgtatagc aggtaattgt taaacttgtt ctggaaataa agaaagaaat cttttggact 1860
atgggcgtgg cattagtatc aagagtagtc ttggtttgta ttatattggc agtgagctta 1920
ttcgtaatag acgtaatctg tcgcacttac gtttagccaa attaggtccg tgaaacagac 1980
acaaacctat atttatgtgg ccacggacaa acgaaaacta taagctactt cgcattctga 2040
ggtcttgttg ggctaataat agactgcaat cacgttgctg gggtggtatc cttaactaac 2100
aatatggtaa gtacggtgat agtgacattc aaaatagggt ggtaacttag catggtctac 2160
ttggtggcag aagtggaagt ggtagttata ttcagcttta tggttttaca ctgtatattt 2220
cacttggcgg tcgccacaat aaagatttag aatccactgg cagaaagtca gcgcattttt 2280
atagcagaca acttgcaaag ggagaggttc atgcaacgtg ttatggtgga tcaagttatc 2340
ttagtaagac ataaacttgt atagacaata acagtggcgg aaattaaggt taagataatt 2400
gtaactatag ttccgggaga gaactattta attccgacaa ctgttatagc caaaatagat 2460
gaaatagagc gtataaaacc tattcttcca agcgtaat 2498
<210> 144
<211> 428
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 144
ggctatagaa aatgatatca taactataac gaatataaca gcaaattaaa atgcactgga 60
taataaaaat taaactaata tttgtagtta gtggtgcaga tttgaacgaa cagtcaggcg 120
aaatggaagt aatagatgat tcatggacga taagtcatta agacatcgaa gactgttttg 180
ttgttatggc agaaacagac aaaatatcag gctacaaaaa tgtatcagag cattaacatg 240
aaaaatccta agagatcgac gaagttatcg actaaattgt tgtaatccaa gaggctgatt 300
gacgtttaga agtaagtggc aatttggttt aaaacaacga taataaaggt tgcgaagaaa 360
tataaaaagt agtcacataa cactgacatt attaaattta gatagacttt accgctaaaa 420
ctgtagtt 428
<210> 145
<211> 2462
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 145
gtgagacgat gaaacttgag aaatcgcact ggcttacata tacacgataa aagactttaa 60
tacaatataa gaagtcgtta ttgaagacgg agatgtatgt taccgcccaa ttttagagat 120
acaaaatgag actgacatag cggttaacta tattagagca cgcctaagca ttgaaggttt 180
agtcatcttc attagagtat actgtattga cggctgaatg caaataaatt gagacaaaac 240
cgatttcttg aattagcacg aagtaagtat aaaactagta gagtgacacc aagtatatag 300
ggggtttata tcgcgtggaa tcgaacaaca tatctattta attagtttaa taacaaatta 360
agtgacttat cgcggaagag agaacaatag attggattaa aaagttgtag taaaccacaa 420
cgaagttagg tagctggtaa ggttatagat gcgttctgtc gttgtagtcc caatgaacat 480
agtatggttt cgcatagtaa ctgacctaaa agaccgccac atagtgaaaa tacttaaaac 540
gcaagtttca taggattaag tggtagaggc tatagaaaat gatatcataa ctataacgaa 600
tataacagca aattaaaatg cactggaagt ggaaaatttc agcaagagag tcgaagtcgt 660
catagattag catggataat ggcaattata gttaaaatag tcgtaaatta gattatggtg 720
caccggggtg taagtttcga actcggtgag gcaatagtag tatagactaa caacaaggta 780
gacattgcaa tgtattgcga gaagaacttc acgaagatat agatacagta cagaatttct 840
aggattaagt acagcagacg tatttacacc tgttatagga tacttgttca cttaatccct 900
gttatgacaa agtagtctca tagaattttt agaacgagaa gatttgaatg gacgtaaagg 960
aagaaggtca aaatggagaa cttaaaaggg gaaatctaga acattgaacc caacattata 1020
caatgatata agaacgaaaa gacgaagaca ataaggtcca tgggatttac ccaaatgagg 1080
acctaaatca ccgggaagaa gtaagtaaac ataacgatat agttttagat tatcgagaag 1140
tcgaagaaga ccgggatagg taacagataa tcgacgtttg ggaagacggt aacgtaagaa 1200
actgaggagg ttaaagaact aagaatcaac aacaagaaac tattgtccct attctactta 1260
ggtatctgct agtatgcgat atggaagtta aagaggaaac agtagtatgc actgtttgag 1320
aaaattagga tttaagaggt ggagaagtcg ttagtttgga agcatagata gttcaaatat 1380
ccacagaagg ctattaaaag atagaagaga gtcgagagat cgattttaaa gtctgagtcg 1440
aaatagtttg gtgcaagatt atccattcaa ttcttatcga aaacttacaa ggtcaacaag 1500
tagagatagc aatataacta aaagctatct attgaacata aatgcgcgac tacagcttgc 1560
gggttaacac ggtcgtcttc attatacgtt taatcgacgc cggcttattc atgcagatat 1620
ttaactcaat cttcgatagg atagaggacg tagtagactt ggatgtctgt catccagaca 1680
tgagacatat acttatatgg ataatggtag tgcagcaaag tcgtataatt taaacggtat 1740
gggacgaagc taacaacata gaggtggaca acgtatagca ggtaattgtt aaacttgttc 1800
tggaaataaa gaaagaaatc ttttggacta tgggcgtggc attagtatca agagtagtct 1860
tggtttgtat tatattggca gtgagcttat tcgtaataga cgtaatctgt cgcacttacg 1920
tttagccaaa ttaggtccgt gaaacagaca caaacctata tttatgtggc cacggacaaa 1980
cgaaaactat aagctacttc gcattctgag gtcttgttgg gctaataata gactgcaatc 2040
acgttgctgg ggtggtatcc ttaactaaca atatggtaag tacggtgata gtgacattca 2100
aaatagggtg gtaacttagc atggtctact tggtggcaga agtggaagtg gtagttatat 2160
tcagctttat ggttttacac tgtatatttc acttggcggt cgccacaata aagatttaga 2220
atccactggc agaaagtcag cgcattttta tagcagacaa cttgcaaagg gagaggttca 2280
tgcaacgtgt tatggtggat caagttatct tagtaagaca taaacttgta tagacaataa 2340
cagtggcgga aattaaggtt aagataattg taactatagt tccgggagag aactatttaa 2400
ttccgacaac tgttatagcc aaaatagatg aaatagagcg tataaaacct attcttccaa 2460
gc 2462
<210> 146
<211> 949
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 146
gtgccaaatt agcgaacaat ttgagaagag cagtgagacg atgaaacttg agaaatcgca 60
ctggcttaca tatacacgat aaaagacttt aatacaatat aagaagtcgt tattgaagac 120
ggagatgtat gttaccgccc aattttagag atacaaaatg agactgacat agcggttaac 180
tatattagag cacgcctaag cattgaaggt ttagtcatct tcattagagt atactgtatt 240
gacggctgaa tgcaaataaa ttgagacaaa accgatttct tgaattagca cgaagtaagt 300
ataaaactag tagagtgaca ccaagtatat agggggttta tatcgcgtgg aatcgaacaa 360
catatctatt taattagttt aataacaaat taagtgactt atcgcggaag agagaacaat 420
agattggatt aaaaagttgt agtaaaccac aacgaagtta ggtagctggt aaggttatag 480
atgcgttctg tcgttgtagt cccaatgaac atagtatggt ttcgcatagt aactgaccta 540
aaagaccgcc acatagtgaa aatacttaaa acgcaagttt cataggatta agtggtagag 600
gctatagaaa atgatatcat aactataacg aatataacag caaattaaaa tgcactggat 660
aataaaaatt aaactaatat ttgtagttag tggtgcagat ttgaacgaac agtcaggcga 720
aatggaagta atagatgatt catggacgat aagtcattaa gacatcgaag actgttttgg 780
atgtagacat atttgtagaa cattaaagaa agatatgagt tctttatttc aaaaacatag 840
atggttggct ggttagcaac gtcaaagccc acagtatcta atgttgttat ggcagaaaca 900
gacaaaatat caggctacaa aaatgtatca gagcattaac atgaaaaat 949
<210> 147
<211> 2326
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 147
gcactggctt acatatacac gataaaagac tttaatacaa tataagaagt cgttattgaa 60
gacggagatg tatgttaccg cccaatttta gagatacaaa atgagactga catagcggtt 120
aactatatta gagcacgcct aagcattgaa ggtttagtca tcttcattag agtatactgt 180
attgacggct gaatgcaaat aaattgagac aaaaccgatt tcttgaatta gcacgaagta 240
agtataaaac tagtagagtg acaccaagta tatagggggt ttatatcgcg tggataataa 300
aaattaaact aatatttgta gttagtggtg cagatttgaa cgaacagtca ggcgaaatgg 360
aagtaataga tgattcatgg acgataagtc attaagacat cgaagactgt tttggaagtg 420
gaaaatttca gcaagagagt cgaagtcgtc atagattagc atggatttcg aagaacgcga 480
agaactaaac gaacaagtta tgaacgaaat tagagtccta ataacctgtt tagtgaattg 540
accagtagtc atataacaaa aacaagaagg ttaggcaaag ctataagcaa atagcattga 600
aatagaaatg gacgagaaga aggctttaaa atggtagtcg tatgcgaacg ctaaggaaga 660
gaaattctag tagaactcgt agttacatac ttggacgaaa gaaaagtcgc aaagatcgga 720
aatcaagacg caaaacaaaa cggagaagtt caaatcgaac tcgtagaaca tatcgctgga 780
acatattaaa ctcttggtat cgctcagtta caaaaggaga cacgtagaca cgaaagaaac 840
tggaacaaca gacatatttg tggatgttag agcaaattat ataaactttc acatgctaac 900
caacgtaatt tgagaagaaa tcatcaagaa ttaaactaaa ggaatggtgg ataatggcaa 960
ttatagttaa aatagtcgta aattagatta tggtgcaccg gggtgtaagt ttcgaactcg 1020
gtgaggcaat agtagtatag actaacaaca aggtagacat tgcaatgtat tgcgagaaga 1080
acttcacgaa gatatagata cagtacagaa tttctaggat taagtacagc agacgtattt 1140
acacctgtta taggatactt gttcacttaa tccctgttat gacaaagtag tctcatagaa 1200
tttttagaac gagaagattt gaatggacgt aaaggaagaa ggtcaaaatg gagaacttaa 1260
aaggggaaat ctagaacatt gaacccaaca ttatacaatg atataagaac gaaaagacga 1320
agacaataag gtccatggga tttacccaaa tgaggaccta aatcaccggg aagaagtaag 1380
taaacataac gatatagttt tagattatcg agaagtcgaa gaagaccggg ataggtaaca 1440
gataatcgac gtttgggaag acggtaacgt aagaaactga ggaggttaaa gaactaagaa 1500
tcaacaacaa gaaactattg tccctattct acttaggtat ctgctagtat gcgatatgga 1560
agttaaagag gaaacagtag tatgcactgt ttgagaaaat taggatttaa gaggtggaga 1620
agtcgttagt ttggaagcat agatagttca aatatccaca gaaggctatt aaaagataga 1680
agagagtcga gagatcgatt ttaaagtctg agtcgaaata gtttggtgca agattatcca 1740
ttcaattctt atcgaaaact tacaaggtca acaagtagag atagcaatat aactaaaagc 1800
tatctattga acataaatgc gcgactacag cttgcgggtt aacacggtcg tcttcattat 1860
acgtttaatc gacgccggct tattcatgca gatatttaac tcaatcttcg ataggataga 1920
ggacgtagta gacttggatg tctgtcatcc agacatgaga catatactta tatggataat 1980
ggtagtgcag caaagtcgta taatttaaac ggtatgggac gaagctaaca acatagaggt 2040
ggacaacgta tagcaggtaa ttgttaaact tgttctggaa ataaagaaag aaatcttttg 2100
gactatgggc gtggcattag tatcaagagt agtcttggtt tgtattatat tggcagtgag 2160
cttattcgta atagacgtaa tctgtcgcac ttacgtttag ccaaattagg tccgtgaaac 2220
agacacaaac ctatatttat gtggccacgg acaaacgaaa actataagct acttcgcatt 2280
ctgaggtctt gttgggctaa taatagactg caatcacgtt gctggg 2326
<210> 148
<211> 889
<212> DNA
<213> Artificial Sequence
<220>
<223> transcript variant
<400> 148
gtgccaaatt agcgaacaat ttgagaagag cagtgagacg atgaaacttg agaaatcgca 60
ctggcttaca tatacacgat aaaagacttt aatacaatat aagaagtcgt tattgaagac 120
ggagatgtat gttaccgccc aattttagag atacaaaatg agactgacat agcggttaac 180
tatattagag cacgcctaag cattgaaggt ttagtcatct tcattagagt atactgtatt 240
gacggctgaa tgcaaataaa ttgagacaaa accgatttct tgaattagca cgaagtaagt 300
ataaaactag tagagtgaca ccaagtatat agggggttta tatcgcgtgt ttaataacaa 360
attaagtgac ttatcgcgga agagagaaca atagattgga ttaaaaagtt gtagtaaacc 420
acaacgaagt taggtagctg gtaaggttat agatgcgttc tgtcgttgta gtcccaatga 480
acatagtatg gtttcgcata gtaactgacc taaaagaccg ccacatagtg aaaatactta 540
aaacgcaagt ttcataggat taagtggtag aggctataga aaatgatatc ataactataa 600
cgaatataac agcaaattaa aatgataata aaaattaaac taatatttgt agttagtgtc 660
aggcgaaatg gaagtaatag atgattcatg gacgataagt cattaagaca tcgaagactg 720
ttttggatgt agacatattt gtagaacatt aaagaaagat atgagttctt tatttcaaaa 780
acatagatgg ttggctggtt agcaacgtca aagcccacag tatctaatgt tgttatggca 840
gaaacagaca aaatatcagg ctacaaaaat gtatcagagc attaacatg 889
<210> 149
<211> 10643
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV1-GENE
<220>
<221> variation
<222> 241
<223> for this and all following instances of 'n': n = any of a,c,g,t
<400> 149
gtgaggcatc tataccgcca cgccctatgt ctttctcacg tataggtgtg ctctcagctg 60
ccgttccggc gctgcttcac ccctttccgc ttatcgcgga tggtaaagtc aaagtttact 120
cagcggtcgc tgttgacctc aggttctcta tcaaaaattt gctggctaaa acggtcggag 180
cttctgctcc actctttcca gcaatccttc tgccagtcgc cttcaaactt gcaatctgtg 240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ngattcgtcg aacgtccggg 420
tagtatagtt atctgcatcg tggtcaccag tatcacagac tacaaaatct caatcctcca 480
ttcccccgtc aggtctatct aaaattcaat cgctgtgttt gcggggtaaa taataggaca 540
agtccgtata atctacccaa tcgcattcat tccagtcaga gggtaccacc gaatttcatc 600
aacaacatta ataattccat aggaactaca ttcttaaatc cttggaactc caaactccta 660
ccttatcacg gttctatccg tcgtcttagg gtcggtctcc tcgtagcatg gcctcgttct 720
cctcgccgta attgcggtcg aaagtacttc agttatttat gnnnnnnnnn nnnnnnnnnn 780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 840
nnnnnnnnnn nngtgaggct tgtccgcgag tgtcaaccgg gttttacaaa ggagaacttc 900
caacatcagt gtatgggatg tttcaaacac ccccagagac ggagacaata gtgtggtcac 960
gtacatttag gaagataaaa ataacaacaa cagaaggtgt gaggcgcaag gtacatgctc 1020
ttaccccact ctcagcacgt agggagcgga gtgtggaaga ccaacaagcc cgtcgcctct 1080
accaaataca gctatcctga ggtgccaggt tagaataggc cctaccacat ctaagccttg 1140
aaacggtctg ttcctcgtgt caagttcttt gtccgcttat accgccatct ctcgttgtgn 1200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1260
nnnnnnnnnn nnnnnnngta caagagttgg ttactctcag tcccattccc aacacatcac 1320
tgagaagtat agagcctagt ggtcattaga aggtcaacat gnnnnnnnnn nnnnnnnnnn 1380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng agtaggtgtt 3840
taggtgtgtc ggagggcaga aaccaacgaa agaaaggaaa cgatcaacac ttatatagtg 3900
tcctgtcggg cccaaatcct aagagacctt aggtttacca cattagtact aaacagcctg 3960
ttgtataccg tgagccccca cttcgatctg taaatggtaa tcccttgtaa aacctcatct 4020
ccaaaaacag tatacgcagg tacagctgat gtgatcctct ctactagtct tctctgagga 4080
accatgagat gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn gatagtgggg gacctgagtc atactagggt 4860
aacttcttat atggtgacat cactcctacc gtagaggggg gacggtagtc tgtgggaaat 4920
ctaccctagt gaagaaaggt aagagaatgt ctgaacatta cctgtagacg aaggtactct 4980
cagaacaact actctcacat acggaaaggt ttgggtcctt ggtcaaagga ctttactgac 5040
tctgcagacg atgaatatct gaaccaacac tactatcaaa gatgtcgtag gtttgtgaga 5100
agggagaaga agtggttgag aagttggtgt tccacaagtt aaagtagaca tacctttagt 5160
acctgtaaag gttcgactag acctctcgtg gtagggcctg gaagtcaaaa gacttctcta 5220
tgggtactag gtaggtagtt agagtacggt ccctggggtg tctcagagtc gaacgttcgg 5280
gggaagttcc taaacatgtt aggatgnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10140
nnnnnnnnnn nnnnnnnnnt tatgataaca agtccaaacg tggacgtcgt cgctgtcacc 10200
tctcggaaca ctagctgagg tggcttaaaa acattccgta actgagtggt caccgggggt 10260
gaaacatgct gagggttcta ccttaacggg aaggtgaaac tctccaatgt ctttgaaagg 10320
actagttgag ataacccaaa ccgaatccgg aggaagagga gaacttggaa aacgttgtac 10380
gacgtcatta ataacgattc cgttcttccc gttcgtgtct ataaggatat tctttcattg 10440
cgaaggtaag cccttttggg tctagatacg gactatactc aaaaacccac agaccttcca 10500
cttggagttg ttttaggaga cggagtagta gagaaaactt gtggcacctt cccagtcggt 10560
tccctacaga ctctccttag tagctcctaa gatcgtcgag ttacacgacg acattgttcc 10620
gactgacgta gaggcattac ttt 10643
<210> 150
<211> 4911
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV2-GENE
<220>
<221> variation
<222> 161
<223> for this and all following instances of 'n': n = any of a,c,g,t
<400> 150
gttggtgtat ttatccgcta cgtggtggat gaacatggat gcgaacgaca tttcgaaata 60
tacgcaatga tatccaaccc taccgaaaca gcaataattg tagaaggtag catatcatgc 120
cgagtcatcg acatgccttt atcgacacac gacgtgattg nnnnnnnnnn nnnnnnnnnn 180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ngagtttact acgttgtagc gagtttagtt 1140
gaaatagttt gtgatgtgta aactaaaaca taccaaatgg taaaacttgt cacccccatt 1200
tacattgcga cagacacagt tatgnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nngagtggat 1440
ggaagtgtgt tcgactgtca agacccttct ataatagtcg aaccagtacg gtaagtgggc 1500
aacatgccca tataagtcga agcatttcaa atggttcatc cagtagacga cgatgtccta 1560
gacagtcatg tctgtcacat ctatcacgcc tcctacgttg tgccataacg aagaataata 1620
gtgataagag acatcgaagc tgtcgtagtc gttcgctaaa ttgcttacaa tttagtgctc 1680
taagtgaaca atgtttcatc ttgagaagca aacgaagtag aagttgacga cgcattcgaa 1740
gacgtggaca atgtgacacg agtatcgaaa catgatccaa cgaacatcga agaagttact 1800
actgaactac gggtcagctt ccccatttga agtcatgtag tggttgtcta ctttttcatt 1860
gaagacgtcc acctcaacgc tatgaacgtt agttgagaca atgttaaagc aaacgacaac 1920
gtcattgtga tctacataca cagtgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngatg gttagcgtaa 2100
acatggtgga acgtactttg actgcgctgc aagaaatggt tgggtcgatc gtaatgctag 2160
tcgttacatc ggaacaagcc aaaacaaatc attcgctgga tttagaccta ctgcacgacg 2220
acgtcgacac aagacattct tgaaaggtaa ttgacgtgga cgtttcagnn nnnnnnnnnn 2280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2520
nnnnnnnnnn nnnnnnngaa ttcaatgcag aaactcctat gcacgtcgaa ctagtctctt 2580
gctcagcgct agtccatgaa aatgtcctag ctttgaacgt ttatcaaatg caagttgtgg 2640
gagttagtca tgtgagagtt gtgcaagaaa gtgttaacgt tctagccgtg ctcagtaaca 2700
attaccattc ggcggtaaca aacgtaagtt gtcactgcac tcatgagcat gaagttagac 2760
cagtagttgg gtcagaaatt agacgtggtt tagtctggtt accgtgnnnn nnnnnnnnnn 2820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2880
nnnnnnnnnn nnnnnnnnnn ngaaagaata gctgaactca aagaagccga caaagataaa 2940
caaagaagaa acggttaata cgattgagga gaaatattca atccaacggc aactattaac 3000
gtttcaacta gaatctacgt ttcatacgcg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnng attccacatc 3120
cgttcttgca attaaagaaa cgatgtagaa aacgctttgg ttggcgacaa cttgggcggc 3180
aaaataatta tggtaggtaa ttgaagtagc gttaaaacgc aaaaagaagg aagcacgnnn 3240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3840
nnnnnnngat cactgcaaaa aggactactc aataatggtt tctaaagtca ttatgctggt 3900
gctccctatg gcggtggtca gtactgtaac taaagatgnn nnnnnnnnnn nnnnnnnnnn 3960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnga ttacggcact tgtagagcac 4080
gtatcagacc cagctttgaa agaaggctga gttcggttcg ggtttcacgt aggcctagaa 4140
cgaggtatag aagtggttaa caaagatttg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn gttaccatgt 4260
aagaagcggt agacgccatg gcctagtagg aagaatgctt gttcacggag ccgacgaagt 4320
tagacgagtg gcagaagaaa gagcattatc ttggtactcg gactgaatgc gtactacggt 4380
cgtccaagtt gcaagaggta ttagagtcat tcgaatagct gtgggagtgg tatttatagc 4440
ataataagtg taaaaaacat tcccaacagc atatgtgtag ccaagaagcg ttgtgctcgc 4500
gactaaaagt caggtagcag caggcattaa cccagtgata gaacatcaaa gtcaaataag 4560
tatggtttag cattactgcg tatcttgcga ttgcgtgctg gtggtcaaca gtgcaaacct 4620
agtggcttcg cactcaaatg tagacaagca ttaaccaact acttctaacg tatgttcagg 4680
aagaatggct attctcgtca ggtgaatgcg taatcgaatg agtagtatgg tcgaacgtcc 4740
cgctatagtc tgacacgatt caggcaaagt tggagtgcaa agccatgatt tggtcgatgc 4800
ggcaaatgtt gcttaggact attctatggt cttgcgtaat tgtgaagatt tgccagttat 4860
ctaaggagac gtggtgattc gctctatagc tgtatctaat ctgccagatt g 4911
<210> 151
<211> 8943
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV3-GENE
<220>
<221> variation
<222> 168
<223> for this and all following instances of 'n': n = any of a,c,g,t
<400> 151
atgacgagaa gcatttcaag aaagcgttgt agcttaaaaa gaacgttgcg gtgctaaagg 60
agaaagtcga aaaagcgaag gagttaaaac aaaagccggt tattaaatgc tggaagaagg 120
aagaacaaca actaaacaag gttgtcaaga gcattaagga agccgtannn nnnnnnnnnn 180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nngtttcaac 540
aatgcccaag ttgacattat tccaaaacgt ttcgtagaaa tgaaagcgct tcgagtaatt 600
aggcgcaaac ttacaggacg ccatggcata tgggtggtag aaccaacgat ggaagcgagt 660
agcgcaatgc cttagcgcac gcctacacta actgcttacg aagttggagc aaaagaaact 720
gaacgtgtca gccaaaattg ccaagaaaca ggagctacca aaagnnnnnn nnnnnnnnnn 780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 900
nntggccaaa caacactcgc aaagaattta tgtgcgcttg gcaggtggag aagcaaatac 960
ttggataccg aatttagagg ccataggtta tggaaaaagt cagtgnnnnn nnnnnnnnnn 1020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3000
nnngtacgaa ttacgaacac cttaacatta gggaaactta gatagttgta caaagtaacg 3060
tataacaagt atcgcgtatg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnga ttagatagta aaagtcgaaa tctttatatt 3600
cggttcgatg tactacgtta ttcgcgactg ttctgtcatg atagtttttt atatagtcct 3660
aataaaagga gtttttaaag taaatgacat ttcagtagta aaagtttaag agctttttgt 3720
tctgccagac gttctgatag ttgaggaaaa cgtgtggtca gctaataact tgtggtatgn 3780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5040
nnnnnnnnnn nnnnnnngag taaacgaaca tccaacagta tgtacaatcg tatgagaaag 5100
gacaaatctg aagacgatat tagagggagt ccaacaagtt tgtgatgatt cacgtaagga 5160
aatcgaaatg taagattatt cgtcaatgga ggtataagac aacacaccaa gtaattatac 5220
gcgacgagtt ttcatgttga cgatccctga gactatatca tacaaaattg acccaaataa 5280
taaactcgtt ccaatagttg aagtgttgat taacacattg agacaagttg tccgtacttt 5340
aatcatcaaa gttttggact gacctataaa tgaaatattc gcgttgtctt cagtttaaga 5400
agtgatatta ttttcggttt caagcctatg tggagagata caggaaatag gtaaactata 5460
actaatataa atatacgcag acgaagcctg ttaactttac caaatccaaa tagcgggaga 5520
cactaaactt acaagaaatg tacggtaaga cagggaaaca gggtttgaag tttggaggta 5580
caaaatctta atccttcaca actgaatcaa catttacatt cggttacgtt cggggtttgt 5640
agtagtaatt gttgaggtaa ttttaattgc acttacagac gtggatttgg tgaaacatta 5700
tgtggtagat tcatatttcc gaatcttaat agacgatttt atgatggtga tcgtggtttc 5760
ttttcaaggt ttggtggacg aaaatgaaaa aatcacaatt taacgtttca tattcatcac 5820
aatccgaaat cgagatggag agaaagtttg actaaacttt gttacagtat ttttgaaggc 5880
aatcaacctg gaactttgga tttcatcaag taaacaccca tatttagcga aaatgcaagc 5940
taactgcgaa ctaacaaggt aactcttttt cgatttcaaa atatggtcag tagcaatatg 6000
ttaagtgatc cattttggag gggtggggat ttgttcaatg aatgaggcaa taaaccaccg 6060
caacctctgt aattgacgag aaacttgtat aaggtcatca aaaagaatag atgaacataa 6120
agattgaata cggctgggtg aggttaattc agatttccca aattatgtag atgaaaagat 6180
ggtaagttta ttgataggta aaaaatcaag agagggtaat aaagaagaaa gaataatcaa 6240
aagatagagc atgcaaacat tacatggtag tattgttata ggcggtatat tggtaaatga 6300
cgatccttga cttagttttt tacatcgaac ggttgcaaat cctagcatac ttgatattaa 6360
tagtagatac tgaaatatat ctgagtatat caagggaaat cgagatgtaa caataagtcg 6420
aggaaattaa ggtcaattta gtgcttatca tagaaataac tacttaagcc cttaacgaac 6480
taactcaaat taacgaggta gaggttattc tgaattgtac gaacgtagtc gaagtttgtt 6540
accaagggta aagccaaaac aaaacgattt gacaagagaa tctattccat gtagtagtgc 6600
gtttgtacga cgttctattc gatgtaaatc attaggacga gggtttgaag caactcggaa 6660
agatggtcgg ttagaattta aaagtactga acggaattaa cgaagttggc tactacctaa 6720
tagtctttgc ttaggattta gtagttcgca attgggtcaa agtggtcgct ttggtcgtcg 6780
acgtcaagac tcaacaagtc atttaccgct gtacgaacca tctcatttaa caggttctca 6840
accaaatagc ggtaggagta gaaagcactt accatcgtac gaactttgac aacgaaaggt 6900
tcaaaggtaa ccaaggcgta gtagtgagtt aggtcaatgt ataaaaactc cctttcttat 6960
tttgagtcgt caatgtagtc gagaaagtgt ccaagcaaaa cgtaacgaaa cggttgagta 7020
aggacttgca cactatgccc ttgcgggttt acctgcttga cgtagtcctg ccacttatta 7080
tccgtgattg ttacctaatg gacaacctaa tcgttagctt aaagaagatg cacttagtgc 7140
cattattatt agacaagata gtccgttctt tagtcgaagt tcttgttgta ataacaaaag 7200
tagagcagta ttttgacgta tagggagaca gtcattaggt cattaaccca gttactaagg 7260
acaacgtaac catcgaagtt attgaacttc agnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7740
nnnnnnnnnn nnnnngatta cgatccgaaa tttcatggac acagatattt gagatcaaca 7800
tttgattcgt tgacgtattt atgttgattc ggttagcgag agttacaaag ttagtaatag 7860
aaagaaagag gaaataataa tcaaaagatt aagcatgcaa acattaagag gacacatatg 7920
tattggtggc atttgcgtta ggttaacgtc tcgtaagacg gtgaagctgc ttaaannnnn 7980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnng tggttaggtc gcttggtagc atatctgtta 8220
ccgaagacac gacagtaaat tgtcaagcaa acactgcgcc ttcttcggtc gcataaagaa 8280
gtgaaccata acgttctcct acttaactcc gcaacgaaaa agagnnnnnn nnnnnnnnnn 8340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncattcg ttcaacatga agtggcttat 8460
gttcgcggag tagtagcgcg taaaagtgta ggtacgcgag ctatcgtgcg gtgtagcatc 8520
gcagtcaaag cttgcgtagg tagcgttgca atctcctgta ctaaagacat gcaactgcca 8580
gcttgtactg ttggcgaaga aagttcagtg gatgttacta accgcgttta acgcgtggac 8640
acggcggcag ttgagccaat cgattacgaa acaagctatg ctaatgttga ccatttggct 8700
cttcgaccag cagtcagccg cttctttacc tgccaacgtt gttcataaca ggcaaaacca 8760
gaaagtcgca taggttggtc aactttcgca gaaccaactg ttactgcgat cttcagcttg 8820
ccttttgtcc cagattaacg tgtaattatt aaacaaagtt cggcagttcc agtcgctatc 8880
gacaaaaccg aaaccacaag ttctgtaatt acgcgttcgg caaagcgcaa tgcgccctaa 8940
tac 8943
<210> 152
<211> 14122
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV4-GENE
<220>
<221> variation
<222> 204
<223> for this and all following instances of 'n': n = any of a,c,g,t
<400> 152
gtgaaaggtg atacatattt acttgacttc ttaagcagag agcgtcaaaa caggttgaac 60
ttatacagaa atactaaaag tcgaacaacc attcgattta ggaatacaga acgataacgc 120
agcagaagta gttgaccacc gtgtaacttg aatggtgatg gtcctggttc tattaataca 180
aatcctttta cttatgctcc gtgnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 480
nnnnnnnnnn nnnnnnnnng caattaggat caggtggtta atctgatacg nnnnnnnnnn 540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnngccaa ggtgaaccag 1200
gacgaagtcg atgtttcaga acctccttta ggccttttag acggtttaaa cgaagcacta 1260
gaccaagtaa taaaagcgga cgttgcacag gtacgtgcag atacagaaca actaaaagaa 1320
ctaaaagaga agaacgacgt gcacgtgcta attatgcgaa ttaacatcgg gttagaaaaa 1380
gtaaactaaa ggaaaatggg taaggcatat gccttactaa attgtgtaaa agaagttcta 1440
ataagaaccg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6120
nnnnnnnnnn nngaatgtat gtaattattc gcaagggttc cataaggcac atatacaaat 6180
ttagaaacaa cccgttacat taacaaaggt gaacggtgtt tcacagatat tagaccatta 6240
ggtaaccaat gacatttcac tatcgaaaag ggtatagtat taactactac aactaatccg 6300
actcgtcgag gtgatttata caggactgca ggtagcaaac gacgaggtgg acgagggtaa 6360
ggtggccgac gaaagggagg acatgcacct agttgaacac gactaggagg acgatggcca 6420
ctacggagtg gaacacaaag gtaaagttgc aataataacc agtacaacaa aagcatacgt 6480
ggaaggtgac aagnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn caaacgatgt cttgaacaac accgtcttca 6780
ttgtttacca tttgctgttg gatttgatat ttagagcgta tgttgaagaa gttggaactc 6840
tggacacatt agagacttat tggatcgatc aagaggaatg nnnnnnnnnn nnnnnnnnnn 6900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7200
nnnncaatac gaagtagttt cactttcgta ggttacccta taacacgcaa atannnnnnn 7260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7440
nnnnnnnnnn nnnngatgta atcaacctct tattaatcat annnnnnnnn nnnnnnnnnn 7500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngtgtaac catcttacgg 9300
atgtaatcta acgtaaacac cagagaaaca accatcaaaa cggcataatg ggcaagcatt 9360
attaggaaca tctaaatata aaaccattgc cttaactcac ataacgctac acttggtaac 9420
accaccatat gcagtgcaag aacgttgggt aagagaacat cgaacgtatg gtctgtttac 9480
ataagctcaa aaataatttt acagggtaaa acgtcaatca ttacttaaca gcagtaatgc 9540
ttacaaatgt ttcggttagt atttaaaacc gtaacgaacg ccacgtgtaa aaacaagagg 9600
ttttattaat attgggtata ttagatgtat ccgtcgatta acccaccata accaaactaa 9660
attaaagcaa cgacttatgc gaaatcctcc ttgtttacaa actaacagta atgcaagtcg 9720
taataaacgt cttaaatatt ttataggtaa aagatttgga ccatatcctc agtactgtaa 9780
tgataaacac cgacgaagtc tacatcgttg caacggaaaa ttccatgaaa gtcgtatgtt 9840
ttatggtaaa cttccgaatt tagcaaaaag ggttgtaaaa ggtatacgtc atcatggtaa 9900
gaaatacagc tgtattagta tataaggttg tagaaaacca cataataata tgtctttagc 9960
actagacatc agatgttaat gacctaacga ttatagtgct gaacaacgtc tacgacaata 10020
taaacctttg caaagactgg tcaaacatca atgttaaaca cgtccagata aaagcaaaaa 10080
ggtaagacga ggattacgga ataattaata tagtgnnnnn nnnnnnnnnn nnnnnnnnnn 10140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc ttgttccaat cggcccggct 11040
tcagtcattc ccggtggcga agccatgtca ccaataaaaa ctatcggcgg caatggaagt 11100
ggtttttcgg aaactgttac gggtgcaagc ggccccagtg cagtttgtgc cttgccaatc 11160
ggcccagctt tcaaacgcaa agttggacga cttattggcc cattctgaca acgtcctgtt 11220
aaactgcccg gacgttcaaa cggcggtatc ggacgactaa cgcgttacgg cggacaactc 11280
gcccccagtc aacaacttgg acacggtaaa tttgaacgct aagtcaactg tagcagttaa 11340
acattgagta ttaaaataga tttaagctag cgttaagaac attaaaaact aaccagccaa 11400
accaaggatt acggctgtgg tgtaatcgat tgcgaaatag catgacaaaa aacttacagt 11460
ttagaaggtg gcggtattac ttaagaacat ttaaaaatag cctgttaact tcaagctgta 11520
gtagcctaaa caggtttcct aatagtatgc aaacaacata gttcaataga agttattaat 11580
aaacatcaaa ttgtctttga acaacacaaa cacgtaagct ttcggcaact aaattaacta 11640
aaaaataact ataattacac agaacacgaa gtcatctgtt tcctattaaa aaataggtac 11700
ttgacaggtt acaatataac ctgtttctag catgtataac aaaattaagc gacgaccgag 11760
cgacgacaac aagcagcagc caggtgggca aaaggctaag actgctttga tgtcctgagc 11820
caacttgccg atacgcagca acattttaga aacgtcatcc tgaccgccgc cgccattgcc 11880
ataaatgata gcttggcggt agccgcccaa aactatgaaa aaaattaaat taaggaaaga 11940
cataaacaag gtagttaagc catgcaccta gaaaattttg aacggctcag ctgcaacata 12000
ttagcgctag aaatgaccta ccataatgat atagaagata attaccatta ctgccaccgc 12060
ctcctccgct gccgcctcct ccatagcagc ttctattcaa acaaactccg ccgccgccac 12120
cgccgccata accaccacca taaccaccgc cgtatacaca aacgccgctc cttctaagtc 12180
ttagctatta ataacaaccg tggaaacaaa aaacgtaata taggctacag ctgtgtcaac 12240
agccaaatcc ataacaacaa aatccatggt gactgtaaca gacactgtta caaccatatt 12300
attaactaga tagtggttac agataatcat gcagcaacaa catataaaga agacggttaa 12360
agttattgac ttatgttagc atgtgcaaat taacataggc tagtcttaac ctgactcgct 12420
gtcgcgactg gcatgcaaag tttgacacgc cgcggctcta gtacgcgtca tctttcagct 12480
gtaataacta caaacacatc aaaaaaagtc ggtttaaaac aacttgtgaa acgtcaactt 12540
ggtaaataaa cctattatta aagaatctag atcaatgtcc aaaaagatta tttccattgt 12600
tacgtctaaa tacagattct gcgaaaacaa gccattagta tagtagaaga actaaccatc 12660
gtatgttcgt gaacgtcgag tcaaagtggc tacatgaaca acgattgcca caagcatggt 12720
cagtgtcaga cttctagctt catcgggtcg tctaagagtg gaaagtccat gacgagcaat 12780
tggaatggca atttgaagag gtactcttcc gacagttgga gtggtctccg cctttgccgt 12840
tgtaaccaat ccaataaacc gcatctgtaa annnnnnnnn nnnnnnnnnn nnnnnnnnnn 12900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 12960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 13020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 13080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 13140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 13200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnncta gcgcgtccgt caacttcaca 13260
ctggttccgt agtcctaacg ttgtagtctg tgcagatgaa gaacgaggtc aacaacgagg 13320
tcacgtatga gataccgtcg gtagtccatg acacccgaaa ggtcacgtca actaagcaat 13380
tgaagttgca attacctctt cggtactgga aattgggcac ccaaccaagc gaaccgaaac 13440
cacactcgtt acggtggctc gtcgttgacg acctgctggt aaagcagaag gtacgcgaag 13500
ttaacgaacc agaccaagta tcggtcgaat ccgaattgtc ttagttacag tgggacttgc 13560
agtacgacgt atcgttgcca caatgcccgt tattgtcacc acagctaatg gtgaaccaag 13620
aacagccaga ctcatggtca acgtaatcca ctgactgggc cacgatcnnn nnnnnnnnnn 13680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 13740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnncacc accggagggt tgctagaccc 13800
taacgtggga gacgctctat ccacagctac atcattcaga agagaaagaa gagggtcttc 13860
tacaggggac attgcagcta acacgctggt tgttcgttgc gtagacgaca cttgttctgt 13920
cgctaccgag gcaagtaaag tcgccaacgt agtatcgcca atggtaacag tagcaatctg 13980
tcattcacca cgcgaactgg actatgttta aatccctttg ccaatcttcc ctattgtccc 14040
gtcaacttcc ttctgtcttg ctttggtaag tgtcaacgtg gcctgaccga atatcacatt 14100
cagaacagtt gctatgctac ac 14122
<210> 153
<211> 12606
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV-5 GENE
<220>
<221> variation
<222> 150
<223> for this and all following instances of 'n': n = any of a,c,g,t
<400> 153
ggaccgaagc atactgcaag acttgtaggc ccatgaatta cccgcttagg caatgggtag 60
acctttcctt gccgcgtgga acaaaccgcc atgagtgttt tacgtttacg gtcggcgacc 120
ggagtcacag cgcgaccaac ggggccaggn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 900
nnnnnnnnnn nnnnnnnnnn nnnnngagga agccttttag ccatcgctat gccgccgctc 960
aaacgcgccg ggtgcaaaag cccagagcaa aggcccatag gcttttccat cggcacgcga 1020
ccgattccat caagtatagc cacggtcgta acttcgacgg cggcaatagt ttatggcgct 1080
aacacctttc catcgctgag tccaaacgta tgacgtgagg tgttaggtgc aatccccatt 1140
cgggacggac acgcgagtaa aggtctaaca tgtttcaact ttccagttag tcgccgtcct 1200
atattggcaa gaccggatgg ccgtcaacca gttccattct gactatttgc cacattgatt 1260
aaagaagtag gagcgttagt cggcgcgtgc gcgggactat ttagcgaagg tcgccgtatc 1320
gcgggtggcg gcgtttccgc cataacaaca agcgtttaag gtcagagtcc gcgacgaatg 1380
aaacgccgtg caagcggctt tggtacggcc agtttagcca aagcctgatc cgttcgcctt 1440
gggttatcat gtaccagtca agcggtcatc gcgggcggcg ttatcatgnn nnnnnnnnnn 1500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2280
nnnnnnnnnn nnnnnnnnga tcgtttgccc gtaaaactaa ctggcaaaag cctaagtgct 2340
gtttcgggtg caatggtata acttcccaca tttagccgaa tagcgccaac agcgttatta 2400
tttgnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2460
nnnnnnnnnn nnnnnnnnnn nnngaaccaa gcagtgggcg atgtcagcga caattccact 2520
ttggtagagg tcgttctttt gtagaaaaca atctaacata actatgacac tttcggtaaa 2580
ttcaccacct ttaccagggt cgtaagtggt caagccacgc cgaccacttc ataagcattg 2640
gtgnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4380
gaaatcgcat cgacacaata aaagtacacc aaccagcaga aaacaggtac atatacagtt 4440
taacgacctg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngatctaa gatgactaca 4560
gtagcatagc catagaacat ggcactgaaa tatcgatggg cgtaaaagtg aacaacgcag 4620
acgatgnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5100
nnnnnnnnnn ngattacgac gccaagccac tataaatgct aattgagtcg aagaaggtac 5160
tcctttttgn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnngaa cacagatatt 5340
gcagaagcgg gaatgaggtt gatattacat caagtatcaa cagacgacct cagaagggtg 5400
gtcttttaaa atgacaacgt acattaagat gcagacaaac actactatgc tgnnnnnnnn 5460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5640
nnnnnnnnnn nnnnnnnnga tgtgaaaatg tcatatgtgc ggcaaaaata gacgacattt 5700
aagaacctag cattatagga tgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5820
nnnnnngagt gttgtattaa ttcactctag agtaatggat cacggtgcca gaaactaagg 5880
tggtgtagga ctagatgcaa gtaacaacgg tcgtactaaa atcagctacg cgatcgccga 5940
cttagaaggc tgagatgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6120
nnnnnnnnnn nnnnnnnnnn nnnngagaaa cttgtctact ggcagacctc actatctttt 6180
aggaaggtca cgaagcggct ggagtgatgg ctagtctcag ccactgtcaa cgggaagcgc 6240
gacgtttatg gtcaatataa actagcagtt taatccgtat ggcgatctta gcggatgtta 6300
caggatgnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6660
nnnnnnnnnn nnnnnnnnnn ngagaagatg acaaagtaga agctagacaa ctatatcaaa 6720
tcgttgtgtg gtcttaaacc gacacagtag cattcatcgt tgnnnnnnnn nnnnnnnnnn 6780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn gatgtggaag gtcacagcct cgttggagga 6900
gatactacgg tcccgctttt cgtgggtgac aaaggtcgca aaggtttcct tagggaggtc 6960
gtttcccgga tctttatcta catctcctgg gtgaagggga tgatctttct ctacatgtcc 7020
tgggtggagg ggagtttcct tgtatgggtg gaacccaacc cgccggtgag ggtgagttac 7080
ggtcggcggt catatgtggg tatgacgggt atgacgtcat aaatagtcgt tgtcaaaatg 7140
ggaggtggaa gtccttactg tagtcacccg tgaaggtgga gaactggcag gacatctcta 7200
ggtcacctaa acgtgcgaag tgtgcgaaat taccaccgta aattcgtcct actgaaagtg 7260
cttacgcatc ttgagagaga ttgcagagag ccaggtcaaa tacattgaga aatctgtata 7320
tgtactttgg taacgctcta aggtaggtac acgttagtga tataaaaaga aggcgacgac 7380
ggtagcagag gtctagaaac cgcatgaacg accaacttat ttgaagagct agtgcggtgg 7440
aattgggtcg gaagaactta aattgttaga gcagtttatg ggtggtaggt tacatctatt 7500
tacttcaaaa cgcggtgccc tagcccacaa gcattgcttt gtaaaattgt tgaaggtaac 7560
ttgtaaaagc cgaacatgaa cgatgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 8940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9840
nnnnnnnnnn nnnnnnnnga tagtagaccg ggaagaccaa cgttttttca ctactccgaa 9900
agaacacact gaagggaacg gtgtaggttc ggtgagtccg ggactaggtg tccatgtcgg 9960
agacctcagt ggtgacgtcc tcgtagtata gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 10080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngtccacg 10140
ctctaagtcg cttgcccaat tgtggctacc gcattgctca gaacttcggg tactggccaa 10200
ccttcaagaa gcctagtctt ggtgcgtcac cccagtcacg tagcataccc gtcatcatct 10260
atggtcgtag gtccaacaat cgtggcgcca ttgggtacca cttcatcaga gctgctcgca 10320
tgaccagcta tatctggaac atcgctggtg ggtcttatgg tcgcttttgt gggaaccatc 10380
atagtcgcaa gtctggcctt cggtatggaa ctcgtcgtcc cgactacaac catagctagt 10440
ctcggtctcg gctttgttgc aatgcccttc gttactactt caacggtcgt ggtgccggtc 10500
aaaccgctcg ctaaagcaag cgaagaaaca gctaaactta gttgtgtcga aacatcctaa 10560
gtggtcgggt tgctcgtgga gcatgcagct agcccagaac ctttagcttg tgtggtcttc 10620
gtctcggtag tcagaaccag gtcggtctga atggttggac tcgccacatc aactaggtca 10680
gctattgaag tgccaactaa aggtcgtatt gaagcaatcg gtcctatggc aagtcaagtg 10740
acagtcgtag gtatggcact tgccgcgcct ccagaactcg gtcaagctac ctcataactc 10800
ggaagtcgac tgctctaaag cgaagttgtc aaacgaacag ctatgccttc gagtaaagca 10860
aggtgcgcaa tagtaacctt ggtaacttcg gaactgcgtc aagccgctaa ctccatcggt 10920
atggaagtcg ctaaagtcgg tcaaacggaa gcggctatcg tcgcaactag tcgaatagtt 10980
gtcgaagagg ccagagcaac catggttgcc attgtcttcg tggtctatgc aagacgtcct 11040
tgcgtcatgg cctaagcatc ttcttcactg gttgctatag cggaagtcgt taccgaactg 11100
gtcgccagtc gaatcgtttg ccccatggta gtcatcacca ccatcgcgga aaccaacggt 11160
ccgaactcac ggtaggtagt ccacgtatgt agcccacctt tcgaaggaat cgtggtcgcc 11220
ggtctcctag aaacggtata tgtcttgcgt cacgcttatg gaccggtcat cctggccagt 11280
agccgacttg tggtcgctat agctttcgct agtccctgcc ttaacgtgca gcatggtatg 11340
gctattgtcg tcccggctac aaccactatc gtggtcttga aactggtcgt cgctacaacc 11400
atcctagcat tggcaccagc ggtcgttgaa gccgaaggta gtctctaact ggttttcgaa 11460
gctagtcaaa cagtagcgcc atatggccta gcctgaacct tagaaaaagg agtcgaaggt 11520
cctaaacccg ctggtcgcga acgaacaaaa acggtcgtta aaggccgtcc ggaagcggaa 11580
ggtcgtcgcc ccaggtgaac aagtcctaaa gaaacaaaaa gtctctgtag tctatttaaa 11640
acccaacgca aacgcgaacg cagaatcgtc tgaacccacg tccatcatta cggattatat 11700
aaggtttctg tttcgttaac taggtagtta ttgatgtcat ccgcactaca agctaacagg 11760
aggtaacaga tagagcatga gtggtagtag ggatgaaaca ggaagtacta attacataca 11820
gggactcctg gttgggtgac cccgggacac gtacgtgtcc taataaacag gaggcgggtg 11880
gtttcctatc tactacggac agggattttc cccgagtagc gaaggatatg aaacttctag 11940
ttatagacat ataagacgta gtccaggaag tcggctgagt ccatgaggtc agttttggag 12000
gagaagtagt tgtcacgatc cttagttaag ataacaaagt ccgagtagtt atcacgactt 12060
gctgactgcg tccactatgt ttccggggtg ggcatgggga cttgcacacg gataactcca 12120
tccggattat taagacgagg tggggtgtgc tgggctccca ggaacttcat cggagtgacg 12180
tagaaccttc agtttgagtc cacgtaggac accagcgcta ttggtgccga cgacgagtac 12240
aaacatccgg aaacttagca tattaggtaa gagtttctgt atgctcggac gtcgtcgtta 12300
gagcagaccc agaaggtgtc catggacaca catcatacaa gacaacttgg tcaactttta 12360
cggggctggg gccaattatc ccgggagtcc tcacgatcag aaaccgactg gtttgtcaca 12420
ctctggttag aggaggggtc accacgatgg gtgagggggt ggtgggtgtt tatacaagag 12480
tctgggactc caaagacgat attacgacga gacgacttat ccacgtactt tgtttcccaa 12540
acccacgcaa ctccaccttt agtccacaca aactagtacg agacacccgg attcaaggtc 12600
gtgacc 12606
<210> 154
<211> 10837
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV6-GENE
<220>
<221> variation
<222> 187
<223> for this and all following instances of 'n': n = any of a,c,g,t
<400> 154
ggcaagacga atctgcgtca acgctaaagg ccgtcaaaaa gcaagagggc gtcgcgcctg 60
ggaaaaaggt agtcaagaaa ccatcaagct taaatgtcgg gaaattgggt ttgcgccgcc 120
ttcaggggca gcgatggggg cgacaattgt ggaccgtatg gactccatta tgctgggact 180
cctcggnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 300
nnnggtagtt gttgaaaaag taggaatatc tagcctagat gtcgtttcag gcgaaggact 360
ctaaggtctt aaaatcgttg gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnngt caaccgctct 480
aaagcgaagt tgttggacaa acagttatgc gtaactgtaa agcaaggtgc ccaagtagac 540
tcttactaat ttgggaacga cggaaagtcg ctaccttcat cggtatggct ttcgctaaag 600
tcggtcaaat ggaagaaggt agtcgaagta ctgttgaaag agtagactga gcgacagtcg 660
aaaccagccc caatgaacaa gacgccattg caaaacgtct atacgctacg gtcaaagacg 720
cttccacacc acatggtata gtggacgccg ttagcctcat gtgtctcact caaagacctt 780
gcgtcacggt catcctcttt gtcagcaacg tagaaatctc cggtctgtcg ataccttgcg 840
taaagctctc atgtagccta ccttacgaag aaatcgcaca agtcggtcgc ccagcggtgg 900
catatgtctt gcctaacgtt tctagaccga tcagcctcac gagtagcctg cttgtggtgt 960
ttatagttta cgctagtcca atctgtatcg tgccgcttgg tatggctatt gtcggcctgg 1020
atgcaagcac taacgtggtc atcagactgg tctgcgctat aatctacgca atagaggcac 1080
cagcggtcgt tgaagccgaa gacgctattt cggtggcttg nnnnnnnnnn nnnnnnnnnn 1140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1260
nnnnnnnnnn nnnnnnnnnn nnnnngaata ttgtttcaat ggtcgtggcg ctggtcagac 1320
tgctcgctaa agtcgtcgaa gaaacagcta gaccatctat tctctgaact tcctaagtgg 1380
tcgggttggt cgtggcgctc atagttagcc cagaacgtcc agtttatgtg gtggtgatct 1440
tggttgccag actcagtatg gtcaaaatag ttgtgctcgc catttcaact agtgcagttg 1500
ctaaagtgcc aactaaggtt cgtcttgaag caatcggtag tatctgcagt caagtcgtag 1560
tcgtaggtat ggcacttgtc gtgcgtctag gacgcgttga agctatctta ttgcccgaag 1620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1740
gagccgaaag tctgggacac gtcgtgggac gtatcgttag gactatggga ctagtcgtct 1800
tcggtcttac aaatgttgca atgccctgnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngcctatg cctcgtatca 2040
tctatggtcg taggtaaagc aatagcggaa acattggatg tgacttcatc aggactgctc 2100
gtatagtgag ctacttatga aacatgaatg gtcggtcttg tggtcgcttt tgtcgaaatc 2160
accgnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 5940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngaaaca ttaaatcaaa 6120
gaagtttatc aaccaattag tacagtggca tgttaagtaa aacagaaaga acgccaagtg 6180
gcaacaaatg acgtaattat ttaagcaaaa agcgtaaacg cttacaaagg ctatttaaat 6240
atcagtaaat cgttggaaat tgggtatgtg ctgccttcat acgcaaaaat ggatgcgaca 6300
gaaacgagtt gtatggcctc cactacgctc gcctgccgcg gaccctaaac gacagtcgtt 6360
tgcccaacta cggctacggc atcgctcaga acttcgggtc ttggcccacc tttctgacgc 6420
ctagtcaacg tgcgtcgcct cagtcttgnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6780
nnnnnnnnnn nnnnnnnnnn nnnnngacaa aaagaagaaa tatcaattgc aaaaataact 6840
ataggtactt ctttgaagaa accaaacgtg agtttctaac acgactaaat ccatttgatc 6900
tttgagaaag tcgaagacga atgnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7980
nnnnnnnnnn nnnnnnnnng tgggtttata tcgcgtatcc atccaactta actgaaacgc 8040
gaagcagtag acagtgttga tcgagatttg cgaagggaaa cagtaaaagt ccagggtgtc 8100
gttaattacg acaaaactaa agactgtata gttagaagga tcaattgggc tgatttagaa 8160
atggtataag ttaaagaaat ggaaacttat tcgacaaaaa gaaaaactca tgatgtatag 8220
atggaaactg ccataatgtc gattcgagtt atatttttag attttggtaa aatatccaac 8280
atgtattaac gaaattttga agtatagatc aaactattct tcaggtacag catcaagcat 8340
tcggtagcat aagccaaaca agtctttgaa gggttggaca tagcgagttg tgtagaaagt 8400
tacgaagact tcaacagaaa aagagtttaa aaggaccacg tatgccaaat cgacaacaat 8460
atagtcgttc tattctgcga tatgtaagat agagacacat cggcaggtag catagaactt 8520
gggtcaatta ttatttaagt gcggtaacaa acaaacttag ggaatattat tgtgctacag 8580
caaatgcctt gaaaagtcga gaaagactac tatactcgtc aagttcgtaa agacttaaca 8640
gtaattgtaa tgcaaatact tagcgagatt gattccttcc cagtagtcat ctttccttta 8700
gatattagaa cagcaatttt agattttgta catagtggag aaaaggacgt cattttaatg 8760
gatgaaccag acgttaacgt catttacttg gtcgttgatt tcgaagactc agtcatcaaa 8820
attgtagctt cgctagctaa tgtgcttaaa atcatcatag tcaaagtgta cgtggtcgtg 8880
gtaataaaca accttcatta ctgtacaaaa gtgccagttt gttacattat cgaacgctgt 8940
atagaggtat catttcacct atttgacaac taggtgataa accttcggtc gctagacgtt 9000
gttgttattg aaaaaatgga agataatcta tacttaatcc aaaacaaccc agaccaagct 9060
cgtatataaa tggaagtcgt caaaattggt ttcgttcaaa taagttggga ctgatgaatc 9120
agttttctga acttcaccgc tattagcgtc ctagttgtct acataattag tatcattatt 9180
gtagtagttt aaatcgctaa caaccaaaaa atccttgaca tgggtaacga cgttattggg 9240
gaaccaatgc tcagtgttgg tgaaagaatc gttaggtcga actattggta cgttctaata 9300
aaagacgaca tagaaattcg ttacataatc aacgtcacta ctaagggcgt attgcaaatt 9360
agttcataaa ttattaacag tttgcaccta atagttctag tccttaaaaa ggtagaagac 9420
gtaggtaatg tcagttgcct caatgtagtc aggtaaaaag tatatgtgct gatggcaaac 9480
ttcatctttg tgagagttga gcatgtataa caacatcact cagtataacc gcttggttac 9540
acaattagta tcatgcctat agaacgcctt atcattcagg tcgtcgtgat agtgaagggg 9600
atcaaagtca aaatctactt tgtcataact ctttacggta tcccaatgct tggtataagt 9660
gcttaagaaa ttgtttaaac agaaactcaa gtataagcga aaacaagtta cctggaaaaa 9720
gaagaagtgc gtataattga tgaacgagtc gaagtcgaag ttgttcaaca agagagttag 9780
gtagtgccgc ttgaaaaagt aatagtgcaa ataagaaagt aagactgtat cggagacgac 9840
tttttaatag tagtaattct cggtacaact aaaccagtaa tttcagacac tgaaatagag 9900
gacttcgtta ggtacgaagc aagttaacta aatgacaatt aaattgaggg taaatatcac 9960
aaagaaatca tggaagattt cgaccgaata caggaaaatt tagattaaag gtttgtcgtc 10020
gttgaaataa gaagaagcga aacggcattc gtttaacaaa acgtcacata tttaggtata 10080
gtagattgcg ttcacaaaga aatttaaagt cttgtaatta tggtggtcga tttattggta 10140
gtatatttgg aaatagcatg caattttgga atggacgaag aacctgacat ctgagctatt 10200
gtaagtttaa tttaccattt cgtcattgta tatgcggtaa acgtaaattt acacatatga 10260
cacgaacttt gagttttatt agcctgccta attgttggta acaatgtaat ggaaattggc 10320
gatgactatg gggaaagagc aatcaactca ccataaattt gtgaacgcag ttaagtaatt 10380
ggcatcgcgc gcctaatcgt ttacattcgc atggaacaag aagaaagaga cctattcgtg 10440
ggagtcaatg gctatgtgga aaaacatgaa ctgccaaatt cggctaacca accagaaatg 10500
gtcatggaaa attcttgcgt caaagttcgc ggtgacgttt acgaagaagc taaacttgtg 10560
cttgtttaga aagttaggtg cgtcctggtt ttagtaaatt tagaaaacca ttttgttgtt 10620
tgcgacagtt aaataaaact taacgacaaa gaagtgactt gcgtcgtaga ttaactggaa 10680
attaaagtgg tatctaaaat ggggtttgcc gatgcggtct tcaaagtcta aaattcttga 10740
agtttgcgtt tggtcgcaaa aattatggat ttagtcgatt attgcctact aagcagcagt 10800
ttagaagttt ttaagatagt tacgctagaa gaccggg 10837
<210> 155
<211> 147317
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV7-GENE
<220>
<221> variation
<222> 350
<223> for this and all following instances of 'n': n = any of a,c,g,t
<400> 155
gtgccaaatt agcgaacaat ttgagaagag cagtgagacg atgaaacttg agaaatcgca 60
ctggcttaca tatacacgat aaaagacttt aatacaatat aagaagtcgt tattgaagac 120
ggagatgtat gttaccgccc aattttagag atacaaaatg agactgacat agcggttaac 180
tatattagag cacgcctaag cattgaaggt ttagtcatct tcattagagt atactgtatt 240
gacggctgaa tgcaaataaa ttgagacaaa accgatttct tgaattagca cgaagtaagt 300
ataaaactag tagagtgaca ccaagtatat agggggttta tatcgcgtgn nnnnnnnnnn 360
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nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 136980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 137940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 138960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 139980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140520
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140580
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 140940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141480
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 141960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 142980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 143040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 143100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 143160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn gacgagaaga aggctttaaa 143220
atggtagtcg tatgcgaacg ctaaggaaga gaaattctag tagaactcgt agttacatac 143280
ttgnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 143340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 143400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 143460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnngac gaaagaaaag 143520
tcgcaaagat cggaaatcaa gacgcaaaac aaaacggaga agttcaaatc gaactcgtag 143580
aacatatcgc tgnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 143640
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 143700
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 143760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 143820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 143880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 143940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144120
nnnnnnnnnn nnnnnnnnga acatattaaa ctcttggtat cgctcagtta caaaaggaga 144180
cacgtagaca cgaaagaaac tggaacaaca gacatatttg tgnnnnnnnn nnnnnnnnnn 144240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144360
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144420
ngatgttaga gcaaattata taaactttca catgctaacc aacgtaattt gagaagaaat 144480
catcaagaat taaactaaag gaatggtgnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144540
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144600
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144660
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144720
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144780
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144900
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 144960
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 145020
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 145080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 145140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 145200
nnnnnngata atggcaatta tagttaaaat agtcgtaaat tagattatgg tgcaccgggg 145260
tgtaagtttc gaactcggtg aggcaatagt agtatagact aacaacaagg tagacattgc 145320
aatgnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 145380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 145440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 145500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 145560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 145620
nnnnnnnnnn nnnnnnnnnn nntattgcga gaagaacttc acgaagatat agatacagta 145680
cagaatttct aggattaagt acagcagacg tatttacacc tgttatagga tacttgttca 145740
cttaatccct gttatgacaa agtagtctca tagaattttt agaacgagaa gatttgaatg 145800
gacgtaaagg aagaaggtca aaatggagaa cttaaaaggg gaaatctaga acattgaacc 145860
caacattata caatgatata agaacgaaaa gacgaagaca ataaggtcca tgggatttac 145920
ccaaatgagg acctaaatca ccgggaagaa gtaagtaaac ataacgatat agttttagat 145980
tatcgagaag tcgaagaaga ccgggatagg taacagataa tcgacgtttg ggaagacggt 146040
aacgtaagaa actgaggagg ttaaagaact aagaatcaac aacaagaaac tattgtccct 146100
attctactta ggtatctgct agtatgcgat atggaagtta aagaggaaac agtagtatgc 146160
actgtttgag aaaattagga tttaagaggt ggagaagtcg ttagtttgga agcatagata 146220
gttcaaatat ccacagaagg ctattaaaag atagaagaga gtcgagagat cgattttaaa 146280
gtctgagtcg aaatagtttg gtgcaagatt atccattcaa ttcttatcga aaacttacaa 146340
ggtcaacaag tagagatagc aatataacta aaagctatct attgaacata aatgcgcgac 146400
tacagcttgc gggttaacac ggtcgtcttc attatacgtt taatcgacgc cggcttattc 146460
atgcagatat ttaactcaat cttcgatagg atagaggacg tagtagactt ggatgtctgt 146520
catccagaca tgagacatat acttatatgg ataatggtag tgcagcaaag tcgtataatt 146580
taaacggtat gggacgaagc taacaacata gaggtggaca acgtatagca ggtaattgtt 146640
aaacttgttc tggaaataaa gaaagaaatc ttttggacta tgggcgtggc attagtatca 146700
agagtagtct tggtttgtat tatattggca gtgagcttat tcgtaataga cgtaatctgt 146760
cgcacttacg tttagccaaa ttaggtccgt gaaacagaca caaacctata tttatgtggc 146820
cacggacaaa cgaaaactat aagctacttc gcattctgag gtcttgttgg gctaataata 146880
gactgcaatc acgttgctgg ggtggtatcc ttaactaaca atatggtaag tacggtgata 146940
gtgacattca aaatagggtg gtaacttagc atggtctact tggtggcaga agtggaagtg 147000
gtagttatat tcagctttat ggttttacac tgtatatttc acttggcggt cgccacaata 147060
aagatttaga atccactggc agaaagtcag cgcattttta tagcagacaa cttgcaaagg 147120
gagaggttca tgcaacgtgt tatggtggat caagttatct tagtaagaca taaacttgta 147180
tagacaataa cagtggcgga aattaaggtt aagataattg taactatagt tccgggagag 147240
aactatttaa ttccgacaac tgttatagcc aaaatagatg aaatagagcg tataaaacct 147300
attcttccaa gcgtaat 147317
<210> 156
<211> 248
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 156
ttgttatggc agaaacagac aaaatatcag gctacaaaaa tgtatcagag cattaacatg 60
aaaaatccta agagatcgac gaagttatcg actaaattgt tgtaatccaa gaggctgatt 120
gacgtttaga agtaagtggc aatttggttt aaaacaacga taataaaggt tgcgaagaaa 180
tataaaaagt agtcacataa cactgacatt attaaattta gatagacttt accgctaaaa 240
ctgtagtt 248
<210> 157
<211> 66
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 157
ttgttatggc agaaacagac aaaatatcag gctacaaaaa tgtatcagag cattaacatg 60
aaaaat 66
<210> 158
<211> 65
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 158
ttgttatggc agaaacagac aaaatatcag gctacaaaaa tgtatcagag cattaacatg 60
aaaaa 65
<210> 159
<211> 104
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 159
gatgtagaca tatttgtaga acattaaaga aagatatgag ttctttattt caaaaacata 60
gatggttggc tggttagcaa cgtcaaagcc cacagtatct aatg 104
<210> 160
<211> 68
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 160
gtcaggcgaa atggaagtaa tagatgattc atggacgata agtcattaag acatcgaaga 60
ctgttttg 68
<210> 161
<211> 122
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 161
gataataaaa attaaactaa tatttgtagt tagtggtgca gatttgaacg aacagtcagg 60
cgaaatggaa gtaatagatg attcatggac gataagtcat taagacatcg aagactgttt 120
tg 122
<210> 162
<211> 58
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 162
ggctatagaa aatgatatca taactataac gaatataaca gcaaattaaa atgcactg 58
<210> 163
<211> 236
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 163
gattggatta aaaagttgta gtaaaccaca acgaagttag gtagctggta aggttataga 60
tgcgttctgt cgttgtagtc ccaatgaaca tagtatggtt tcgcatagta actgacctaa 120
aagaccgcca catagtgaaa atacttaaaa cgcaagtttc ataggattaa gtggtagagg 180
ctatagaaaa tgatatcata actataacga atataacagc aaattaaaat gcactg 236
<210> 164
<211> 276
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 164
gtttaataac aaattaagtg acttatcgcg gaagagagaa caatagattg gattaaaaag 60
ttgtagtaaa ccacaacgaa gttaggtagc tggtaaggtt atagatgcgt tctgtcgttg 120
tagtcccaat gaacatagta tggtttcgca tagtaactga cctaaaagac cgccacatag 180
tgaaaatact taaaacgcaa gtttcatagg attaagtggt agaggctata gaaaatgata 240
tcataactat aacgaatata acagcaaatt aaaatg 276
<210> 165
<211> 308
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 165
gaatcgaaca acatatctat ttaattagtt taataacaaa ttaagtgact tatcgcggaa 60
gagagaacaa tagattggat taaaaagttg tagtaaacca caacgaagtt aggtagctgg 120
taaggttata gatgcgttct gtcgttgtag tcccaatgaa catagtatgg tttcgcatag 180
taactgacct aaaagaccgc cacatagtga aaatacttaa aacgcaagtt tcataggatt 240
aagtggtaga ggctatagaa aatgatatca taactataac gaatataaca gcaaattaaa 300
atgcactg 308
<210> 166
<211> 310
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 166
gatgaaactt gagaaatcgc actggcttac atatacacga taaaagactt taatacaata 60
taagaagtcg ttattgaaga cggagatgta tgttaccgcc caattttaga gatacaaaat 120
gagactgaca tagcggttaa ctatattaga gcacgcctaa gcattgaagg tttagtcatc 180
ttcattagag tatactgtat tgacggctga atgcaaataa attgagacaa aaccgatttc 240
ttgaattagc acgaagtaag tataaaacta gtagagtgac accaagtata tagggggttt 300
atatcgcgtg 310
<210> 167
<211> 349
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 167
gtgccaaatt agcgaacaat ttgagaagag cagtgagacg atgaaacttg agaaatcgca 60
ctggcttaca tatacacgat aaaagacttt aatacaatat aagaagtcgt tattgaagac 120
ggagatgtat gttaccgccc aattttagag atacaaaatg agactgacat agcggttaac 180
tatattagag cacgcctaag cattgaaggt ttagtcatct tcattagagt atactgtatt 240
gacggctgaa tgcaaataaa ttgagacaaa accgatttct tgaattagca cgaagtaagt 300
ataaaactag tagagtgaca ccaagtatat agggggttta tatcgcgtg 349
<210> 168
<211> 1675
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 168
tattgcgaga agaacttcac gaagatatag atacagtaca gaatttctag gattaagtac 60
agcagacgta tttacacctg ttataggata cttgttcact taatccctgt tatgacaaag 120
tagtctcata gaatttttag aacgagaaga tttgaatgga cgtaaaggaa gaaggtcaaa 180
atggagaact taaaagggga aatctagaac attgaaccca acattataca atgatataag 240
aacgaaaaga cgaagacaat aaggtccatg ggatttaccc aaatgaggac ctaaatcacc 300
gggaagaagt aagtaaacat aacgatatag ttttagatta tcgagaagtc gaagaagacc 360
gggataggta acagataatc gacgtttggg aagacggtaa cgtaagaaac tgaggaggtt 420
aaagaactaa gaatcaacaa caagaaacta ttgtccctat tctacttagg tatctgctag 480
tatgcgatat ggaagttaaa gaggaaacag tagtatgcac tgtttgagaa aattaggatt 540
taagaggtgg agaagtcgtt agtttggaag catagatagt tcaaatatcc acagaaggct 600
attaaaagat agaagagagt cgagagatcg attttaaagt ctgagtcgaa atagtttggt 660
gcaagattat ccattcaatt cttatcgaaa acttacaagg tcaacaagta gagatagcaa 720
tataactaaa agctatctat tgaacataaa tgcgcgacta cagcttgcgg gttaacacgg 780
tcgtcttcat tatacgttta atcgacgccg gcttattcat gcagatattt aactcaatct 840
tcgataggat agaggacgta gtagacttgg atgtctgtca tccagacatg agacatatac 900
ttatatggat aatggtagtg cagcaaagtc gtataattta aacggtatgg gacgaagcta 960
acaacataga ggtggacaac gtatagcagg taattgttaa acttgttctg gaaataaaga 1020
aagaaatctt ttggactatg ggcgtggcat tagtatcaag agtagtcttg gtttgtatta 1080
tattggcagt gagcttattc gtaatagacg taatctgtcg cacttacgtt tagccaaatt 1140
aggtccgtga aacagacaca aacctatatt tatgtggcca cggacaaacg aaaactataa 1200
gctacttcgc attctgaggt cttgttgggc taataataga ctgcaatcac gttgctgggg 1260
tggtatcctt aactaacaat atggtaagta cggtgatagt gacattcaaa atagggtggt 1320
aacttagcat ggtctacttg gtggcagaag tggaagtggt agttatattc agctttatgg 1380
ttttacactg tatatttcac ttggcggtcg ccacaataaa gatttagaat ccactggcag 1440
aaagtcagcg catttttata gcagacaact tgcaaaggga gaggttcatg caacgtgtta 1500
tggtggatca agttatctta gtaagacata aacttgtata gacaataaca gtggcggaaa 1560
ttaaggttaa gataattgta actatagttc cgggagagaa ctatttaatt ccgacaactg 1620
ttatagccaa aatagatgaa atagagcgta taaaacctat tcttccaagc gtaat 1675
<210> 169
<211> 118
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 169
gataatggca attatagtta aaatagtcgt aaattagatt atggtgcacc ggggtgtaag 60
tttcgaactc ggtgaggcaa tagtagtata gactaacaac aaggtagaca ttgcaatg 118
<210> 170
<211> 87
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 170
gatgttagag caaattatat aaactttcac atgctaacca acgtaatttg agaagaaatc 60
atcaagaatt aaactaaagg aatggtg 87
<210> 171
<211> 84
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 171
gaacatatta aactcttggt atcgctcagt tacaaaagga gacacgtaga cacgaaagaa 60
actggaacaa cagacatatt tgtg 84
<210> 172
<211> 85
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 172
gacgaaagaa aagtcgcaaa gatcggaaat caagacgcaa aacaaaacgg agaagttcaa 60
atcgaactcg tagaacatat cgctg 85
<210> 173
<211> 49
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 173
gaagtggaaa atttcagcaa gagagtcgaa gtcgtcatag attagcatg 49
<210> 174
<211> 95
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 174
gaagtgcgta taattgatga acgagtcgaa gtcgaagttg ttcaacaaga gagttaggta 60
gtgccgcttg aaaaagtaat agtgcaaata agaaa 95
<210> 175
<211> 65
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 175
gaagtgcgta taattgatga acgagtcgaa gtcgaagttg ttcaacaaga gagttaggta 60
gtgcc 65
<210> 176
<211> 385
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 176
gaagtgcgta taattgatga acgagtcgaa gtcgaagttg ttcaacaaga gagttaggta 60
gtgccgcttg aaaaagtaat agtgcaaata agaaagtaag actgtatcgg agacgacttt 120
ttaatagtag taattctcgg tacaactaaa ccagtaattt cagacactga aatagaggac 180
ttcgttaggt acgaagcaag ttaactaaat gacaattaaa ttgagggtaa atatcacaaa 240
gaaatcatgg aagatttcga ccgaatacag gaaaatttag attaaaggtt tgtcgtcgtt 300
gaaataagaa gaagcgaaac ggcattcgtt taacaaaacg tcacatattt aggtatagta 360
gattgcgttc acaaagaaat ttaaa 385
<210> 177
<211> 98
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 177
gaagaagtgc gtataattga tgaacgagtc gaagtcgaag ttgttcaaca agagagttag 60
gtagtgccgc ttgaaaaagt aatagtgcaa ataagaaa 98
<210> 178
<211> 581
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 178
ggggaaccaa tgctcagtgt tggtgaaaga atcgttaggt cgaactattg gtacgttcta 60
ataaaagacg acatagaaat tcgttacata atcaacgtca ctactaaggg cgtattgcaa 120
attagttcat aaattattaa cagtttgcac ctaatagttc tagtccttaa aaaggtagaa 180
gacgtaggta atgtcagttg cctcaatgta gtcaggtaaa aagtatatgt gctgatggca 240
aacttcatct ttgtgagagt tgagcatgta taacaacatc actcagtata accgcttggt 300
tacacaatta gtatcatgcc tatagaacgc cttatcattc aggtcgtcgt gatagtgaag 360
gggatcaaag tcaaaatcta ctttgtcata actctttacg gtatcccaat gcttggtata 420
agtgcttaag aaattgttta aacagaaact caagtataag cgaaaacaag ttacctggaa 480
aaagaagaag tgcgtataat tgatgaacga gtcgaagtcg aagttgttca acaagagagt 540
taggtagtgc cgcttgaaaa agtaatagtg caaataagaa a 581
<210> 179
<211> 96
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 179
agtagactga gcgacagtcg aaaccagccc caatgaacaa gacgccattg caaaacgtct 60
atacgctacg gtcaaagacg cttccacacc acatgg 96
<210> 180
<211> 95
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 180
agtagactga gcgacagtcg aaaccagccc caatgaacaa gacgccattg caaaacgtct 60
atacgctacg gtcaaagacg cttccacacc acatg 95
<210> 181
<211> 310
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 181
agtagactga gcgacagtcg aaaccagccc caatgaacaa gacgccattg caaaacgtct 60
atacgctacg gtcaaagacg cttccacacc acatggtata gtggacgccg ttagcctcat 120
gtgtctcact caaagacctt gcgtcacggt catcctcttt gtcagcaacg tagaaatctc 180
cggtctgtcg ataccttgcg taaagctctc atgtagccta ccttacgaag aaatcgcaca 240
agtcggtcgc ccagcggtgg catatgtctt gcctaacgtt tctagaccga tcagcctcac 300
gagtagcctg 310
<210> 182
<211> 1969
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 182
gtgggtttat atcgcgtatc catccaactt aactgaaacg cgaagcagta gacagtgttg 60
atcgagattt gcgaagggaa acagtaaaag tccagggtgt cgttaattac gacaaaacta 120
aagactgtat agttagaagg atcaattggg ctgatttaga aatggtataa gttaaagaaa 180
tggaaactta ttcgacaaaa agaaaaactc atgatgtata gatggaaact gccataatgt 240
cgattcgagt tatattttta gattttggta aaatatccaa catgtattaa cgaaattttg 300
aagtatagat caaactattc ttcaggtaca gcatcaagca ttcggtagca taagccaaac 360
aagtctttga agggttggac atagcgagtt gtgtagaaag ttacgaagac ttcaacagaa 420
aaagagttta aaaggaccac gtatgccaaa tcgacaacaa tatagtcgtt ctattctgcg 480
atatgtaaga tagagacaca tcggcaggta gcatagaact tgggtcaatt attatttaag 540
tgcggtaaca aacaaactta gggaatatta ttgtgctaca gcaaatgcct tgaaaagtcg 600
agaaagacta ctatactcgt caagttcgta aagacttaac agtaattgta atgcaaatac 660
ttagcgagat tgattccttc ccagtagtca tctttccttt agatattaga acagcaattt 720
tagattttgt acatagtgga gaaaaggacg tcattttaat ggatgaacca gacgttaacg 780
tcatttactt ggtcgttgat ttcgaagact cagtcatcaa aattgtagct tcgctagcta 840
atgtgcttaa aatcatcata gtcaaagtgt acgtggtcgt ggtaataaac aaccttcatt 900
actgtacaaa agtgccagtt tgttacatta tcgaacgctg tatagaggta tcatttcacc 960
tatttgacaa ctaggtgata aaccttcggt cgctagacgt tgttgttatt gaaaaaatgg 1020
aagataatct atacttaatc caaaacaacc cagaccaagc tcgtatataa atggaagtcg 1080
tcaaaattgg tttcgttcaa ataagttggg actgatgaat cagttttctg aacttcaccg 1140
ctattagcgt cctagttgtc tacataatta gtatcattat tgtagtagtt taaatcgcta 1200
acaaccaaaa aatccttgac atgggtaacg acgttattgg ggaaccaatg ctcagtgttg 1260
gtgaaagaat cgttaggtcg aactattggt acgttctaat aaaagacgac atagaaattc 1320
gttacataat caacgtcact actaagggcg tattgcaaat tagttcataa attattaaca 1380
gtttgcacct aatagttcta gtccttaaaa aggtagaaga cgtaggtaat gtcagttgcc 1440
tcaatgtagt caggtaaaaa gtatatgtgc tgatggcaaa cttcatcttt gtgagagttg 1500
agcatgtata acaacatcac tcagtataac cgcttggtta cacaattagt atcatgccta 1560
tagaacgcct tatcattcag gtcgtcgtga tagtgaaggg gatcaaagtc aaaatctact 1620
ttgtcataac tctttacggt atcccaatgc ttggtataag tgcttaagaa attgtttaaa 1680
cagaaactca agtataagcg aaaacaagtt acctggaaaa agaagaagtg cgtataattg 1740
atgaacgagt cgaagtcgaa gttgttcaac aagagagtta ggtagtgccg cttgaaaaag 1800
taatagtgca aataagaaag taagactgta tcggagacga ctttttaata gtagtaattc 1860
tcggtacaac taaaccagta atttcagaca ctgaaataga ggacttcgtt aggtacgaag 1920
caagttaact aaatgacaat taaattgagg gtaaatatca caaagaaat 1969
<210> 183
<211> 278
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 183
ttactaattt gggaacgacg gaaagtcgct accttcatcg gtatggcttt cgctaaagtc 60
ggtcaaatgg aagaaggtag tcgaagtact gttgaaagag tagactgagc gacagtcgaa 120
accagcccca atgaacaaga cgccattgca aaacgtctat acgctacggt caaagacgct 180
tccacaccac atggtatagt ggacgccgtt agcctcatgt gtctcactca aagaccttgc 240
gtcacggtca tcctctttgt cagcaacgta gaaatctc 278
<210> 184
<211> 118
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 184
gacaaaaaga agaaatatca attgcaaaaa taactatagg tacttctttg aagaaaccaa 60
acgtgagttt ctaacacgac taaatccatt tgatctttga gaaagtcgaa gacgaatg 118
<210> 185
<211> 267
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 185
gtcaaccgct ctaaagcgaa gttgttggac aaacagttat gcgtaactgt aaagcaaggt 60
gcccaagtag actcttacta atttgggaac gacggaaagt cgctaccttc atcggtatgg 120
ctttcgctaa agtcggtcaa atggaagaag gtagtcgaag tactgttgaa agagtagact 180
gagcgacagt cgaaaccagc cccaatgaac aagacgccat tgcaaaacgt ctatacgcta 240
cggtcaaaga cgcttccaca ccacatg 267
<210> 186
<211> 73
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 186
gtcaaccgct ctaaagcgaa gttgttggac aaacagttat gcgtaactgt aaagcaaggt 60
gcccaagtag act 73
<210> 187
<211> 78
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 187
ggtagttgtt gaaaaagtag gaatatctag cctagatgtc gtttcaggcg aaggactcta 60
aggtcttaaa atcgttgg 78
<210> 188
<211> 49
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 188
gggcgacaat tgtggaccgt atggactcca ttatgctggg actcctcgg 49
<210> 189
<211> 56
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 189
gcgatggggg cgacaattgt ggaccgtatg gactccatta tgctgggact cctcgg 56
<210> 190
<211> 62
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 190
ggggcagcga tgggggcgac aattgtggac cgtatggact ccattatgct gggactcctc 60
gg 62
<210> 191
<211> 99
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 191
gcttaaatgt cgggaaattg ggtttgcgcc gccttcaggg gcagcgatgg gggcgacaat 60
tgtggaccgt atggactcca ttatgctggg actcctcgg 99
<210> 192
<211> 58
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 192
tgagctactt atgaaacatg aatggtcggt cttgtggtcg cttttgtcga aatcaccg 58
<210> 193
<211> 59
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 193
gtgagctact tatgaaacat gaatggtcgg tcttgtggtc gcttttgtcg aaatcaccg 59
<210> 194
<211> 49
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 194
ggactatggg actagtcgtc ttcggtctta caaatgttgc aatgccctg 49
<210> 195
<211> 88
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 195
gagccgaaag tctgggacac gtcgtgggac gtatcgttag gactatggga ctagtcgtct 60
tcggtcttac aaatgttgca atgccctg 88
<210> 196
<211> 74
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 196
gagccgaaag tctgggacac gtcgtgggac gtatcgttag gactatggga ctagtcgtct 60
tcggtcttac aaat 74
<210> 197
<211> 186
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 197
ggcaagacga atctgcgtca acgctaaagg ccgtcaaaaa gcaagagggc gtcgcgcctg 60
ggaaaaaggt agtcaagaaa ccatcaagct taaatgtcgg gaaattgggt ttgcgccgcc 120
ttcaggggca gcgatggggg cgacaattgt ggaccgtatg gactccatta tgctgggact 180
cctcgg 186
<210> 198
<211> 104
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 198
ggttcgtctt gaagcaatcg gtagtatctg cagtcaagtc gtagtcgtag gtatggcact 60
tgtcgtgcgt ctaggacgcg ttgaagctat cttattgccc gaag 104
<210> 199
<211> 148
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 199
gtgctcgcca tttcaactag tgcagttgct aaagtgccaa ctaaggttcg tcttgaagca 60
atcggtagta tctgcagtca agtcgtagtc gtaggtatgg cacttgtcgt gcgtctagga 120
cgcgttgaag ctatcttatt gcccgaag 148
<210> 200
<211> 150
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 200
ttgtgctcgc catttcaact agtgcagttg ctaaagtgcc aactaaggtt cgtcttgaag 60
caatcggtag tatctgcagt caagtcgtag tcgtaggtat ggcacttgtc gtgcgtctag 120
gacgcgttga agctatctta ttgcccgaag 150
<210> 201
<211> 70
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 201
ttgtgctcgc catttcaact agtgcagttg ctaaagtgcc aactaaggtt cgtcttgaag 60
caatcggtag 70
<210> 202
<211> 151
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 202
gttgtgctcg ccatttcaac tagtgcagtt gctaaagtgc caactaaggt tcgtcttgaa 60
gcaatcggta gtatctgcag tcaagtcgta gtcgtaggta tggcacttgt cgtgcgtcta 120
ggacgcgttg aagctatctt attgcccgaa g 151
<210> 203
<211> 190
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 203
tattctctga acttcctaag tggtcgggtt ggtcgtggcg ctcatagtta gcccagaacg 60
tccagtttat gtggtggtga tcttggttgc cagactcagt atggtcaaaa tagttgtgct 120
cgccatttca actagtgcag ttgctaaagt gccaactaag gttcgtcttg aagcaatcgg 180
tagtatctgc 190
<210> 204
<211> 335
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 204
gaatattgtt tcaatggtcg tggcgctggt cagactgctc gctaaagtcg tcgaagaaac 60
agctagacca tctattctct gaacttccta agtggtcggg ttggtcgtgg cgctcatagt 120
tagcccagaa cgtccagttt atgtggtggt gatcttggtt gccagactca gtatggtcaa 180
aatagttgtg ctcgccattt caactagtgc agttgctaaa gtgccaacta aggttcgtct 240
tgaagcaatc ggtagtatct gcagtcaagt cgtagtcgta ggtatggcac ttgtcgtgcg 300
tctaggacgc gttgaagcta tcttattgcc cgaag 335
<210> 205
<211> 640
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 205
attgtaagtt taatttacca tttcgtcatt gtatatgcgg taaacgtaaa tttacacata 60
tgacacgaac tttgagtttt attagcctgc ctaattgttg gtaacaatgt aatggaaatt 120
ggcgatgact atggggaaag agcaatcaac tcaccataaa tttgtgaacg cagttaagta 180
attggcatcg cgcgcctaat cgtttacatt cgcatggaac aagaagaaag agacctattc 240
gtgggagtca atggctatgt ggaaaaacat gaactgccaa attcggctaa ccaaccagaa 300
atggtcatgg aaaattcttg cgtcaaagtt cgcggtgacg tttacgaaga agctaaactt 360
gtgcttgttt agaaagttag gtgcgtcctg gttttagtaa atttagaaaa ccattttgtt 420
gtttgcgaca gttaaataaa acttaacgac aaagaagtga cttgcgtcgt agattaactg 480
gaaattaaag tggtatctaa aatggggttt gccgatgcgg tcttcaaagt ctaaaattct 540
tgaagtttgc gtttggtcgc aaaaattatg gatttagtcg attattgcct actaagcagc 600
agtttagaag tttttaagat agttacgcta gaagaccggg 640
<210> 206
<211> 630
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 206
attgtaagtt taatttacca tttcgtcatt gtatatgcgg taaacgtaaa tttacacata 60
tgacacgaac tttgagtttt attagcctgc ctaattgttg gtaacaatgt aatggaaatt 120
ggcgatgact atggggaaag agcaatcaac tcaccataaa tttgtgaacg cagttaagta 180
attggcatcg cgcgcctaat cgtttacatt cgcatggaac aagaagaaag agacctattc 240
gtgggagtca atggctatgt ggaaaaacat gaactgccaa attcggctaa ccaaccagaa 300
atggtcatgg aaaattcttg cgtcaaagtt cgcggtgacg tttacgaaga agctaaactt 360
gtgcttgttt agaaagttag gtgcgtcctg gttttagtaa atttagaaaa ccattttgtt 420
gtttgcgaca gttaaataaa acttaacgac aaagaagtga cttgcgtcgt agattaactg 480
gaaattaaag tggtatctaa aatggggttt gccgatgcgg tcttcaaagt ctaaaattct 540
tgaagtttgc gtttggtcgc aaaaattatg gatttagtcg attattgcct actaagcagc 600
agtttagaag tttttaagat agttacgcta 630
<210> 207
<211> 628
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 207
attgtaagtt taatttacca tttcgtcatt gtatatgcgg taaacgtaaa tttacacata 60
tgacacgaac tttgagtttt attagcctgc ctaattgttg gtaacaatgt aatggaaatt 120
ggcgatgact atggggaaag agcaatcaac tcaccataaa tttgtgaacg cagttaagta 180
attggcatcg cgcgcctaat cgtttacatt cgcatggaac aagaagaaag agacctattc 240
gtgggagtca atggctatgt ggaaaaacat gaactgccaa attcggctaa ccaaccagaa 300
atggtcatgg aaaattcttg cgtcaaagtt cgcggtgacg tttacgaaga agctaaactt 360
gtgcttgttt agaaagttag gtgcgtcctg gttttagtaa atttagaaaa ccattttgtt 420
gtttgcgaca gttaaataaa acttaacgac aaagaagtga cttgcgtcgt agattaactg 480
gaaattaaag tggtatctaa aatggggttt gccgatgcgg tcttcaaagt ctaaaattct 540
tgaagtttgc gtttggtcgc aaaaattatg gatttagtcg attattgcct actaagcagc 600
agtttagaag tttttaagat agttacgc 628
<210> 208
<211> 493
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 208
attgtaagtt taatttacca tttcgtcatt gtatatgcgg taaacgtaaa tttacacata 60
tgacacgaac tttgagtttt attagcctgc ctaattgttg gtaacaatgt aatggaaatt 120
ggcgatgact atggggaaag agcaatcaac tcaccataaa tttgtgaacg cagttaagta 180
attggcatcg cgcgcctaat cgtttacatt cgcatggaac aagaagaaag agacctattc 240
gtgggagtca atggctatgt ggaaaaacat gaactgccaa attcggctaa ccaaccagaa 300
atggtcatgg aaaattcttg cgtcaaagtt cgcggtgacg tttacgaaga agctaaactt 360
gtgcttgttt agaaagttag gtgcgtcctg gttttagtaa atttagaaaa ccattttgtt 420
gtttgcgaca gttaaataaa acttaacgac aaagaagtga cttgcgtcgt agattaactg 480
gaaattaaag tgg 493
<210> 209
<211> 133
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 209
attgtaagtt taatttacca tttcgtcatt gtatatgcgg taaacgtaaa tttacacata 60
tgacacgaac tttgagtttt attagcctgc ctaattgttg gtaacaatgt aatggaaatt 120
ggcgatgact atg 133
<210> 210
<211> 82
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 210
attgtaagtt taatttacca tttcgtcatt gtatatgcgg taaacgtaaa tttacacata 60
tgacacgaac tttgagtttt at 82
<210> 211
<211> 276
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 211
gctctcatgt agcctacctt acgaagaaat cgcacaagtc ggtcgcccag cggtggcata 60
tgtcttgcct aacgtttcta gaccgatcag cctcacgagt agcctgcttg tggtgtttat 120
agtttacgct agtccaatct gtatcgtgcc gcttggtatg gctattgtcg gcctggatgc 180
aagcactaac gtggtcatca gactggtctg cgctataatc tacgcaatag aggcaccagc 240
ggtcgttgaa gccgaagacg ctatttcggt ggcttg 276
<210> 212
<211> 182
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 212
gctctcatgt agcctacctt acgaagaaat cgcacaagtc ggtcgcccag cggtggcata 60
tgtcttgcct aacgtttcta gaccgatcag cctcacgagt agcctgcttg tggtgtttat 120
agtttacgct agtccaatct gtatcgtgcc gcttggtatg gctattgtcg gcctggatgc 180
aa 182
<210> 213
<211> 300
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 213
aagaagcgaa acggcattcg tttaacaaaa cgtcacatat ttaggtatag tagattgcgt 60
tcacaaagaa atttaaagtc ttgtaattat ggtggtcgat ttattggtag tatatttgga 120
aatagcatgc aattttggaa tggacgaaga acctgacatc tgagctattg taagtttaat 180
ttaccatttc gtcattgtat atgcggtaaa cgtaaattta cacatatgac acgaactttg 240
agttttatta gcctgcctaa ttgttggtaa caatgtaatg gaaattggcg atgactatgg 300
<210> 214
<211> 77
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 214
aagaagcgaa acggcattcg tttaacaaaa cgtcacatat ttaggtatag tagattgcgt 60
tcacaaagaa atttaaa 77
<210> 215
<211> 84
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 215
aaataagaag aagcgaaacg gcattcgttt aacaaaacgt cacatattta ggtatagtag 60
attgcgttca caaagaaatt taaa 84
<210> 216
<211> 132
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 216
gaacttaaat tgttagagca gtttatgggt ggtaggttac atctatttac ttcaaaacgc 60
ggtgccctag cccacaagca ttgctttgta aaattgttga aggtaacttg taaaagccga 120
acatgaacga tg 132
<210> 217
<211> 66
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 217
gtatatgtac tttggtaacg ctctaaggta ggtacacgtt agtgatataa aaagaaggcg 60
acgacg 66
<210> 218
<211> 104
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 218
agattgcaga gagccaggtc aaatacattg agaaatctgt atatgtactt tggtaacgct 60
ctaaggtagg tacacgttag tgatataaaa agaaggcgac gacg 104
<210> 219
<211> 384
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 219
gtcacctaaa cgtgcgaagt gtgcgaaatt accaccgtaa attcgtccta ctgaaagtgc 60
ttacgcatct tgagagagat tgcagagagc caggtcaaat acattgagaa atctgtatat 120
gtactttggt aacgctctaa ggtaggtaca cgttagtgat ataaaaagaa ggcgacgacg 180
gtagcagagg tctagaaacc gcatgaacga ccaacttatt tgaagagcta gtgcggtgga 240
attgggtcgg aagaacttaa attgttagag cagtttatgg gtggtaggtt acatctattt 300
acttcaaaac gcggtgccct agcccacaag cattgctttg taaaattgtt gaaggtaact 360
tgtaaaagcc gaacatgaac gatg 384
<210> 220
<211> 511
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 220
gatgtggaag gtcacagcct cgttggagga gatactacgg tcccgctttt cgtgggtgac 60
aaaggtcgca aaggtttcct tagggaggtc gtttcccgga tctttatcta catctcctgg 120
gtgaagggga tgatctttct ctacatgtcc tgggtggagg ggagtttcct tgtatgggtg 180
gaacccaacc cgccggtgag ggtgagttac ggtcggcggt catatgtggg tatgacgggt 240
atgacgtcat aaatagtcgt tgtcaaaatg ggaggtggaa gtccttactg tagtcacccg 300
tgaaggtgga gaactggcag gacatctcta ggtcacctaa acgtgcgaag tgtgcgaaat 360
taccaccgta aattcgtcct actgaaagtg cttacgcatc ttgagagaga ttgcagagag 420
ccaggtcaaa tacattgaga aatctgtata tgtactttgg taacgctcta aggtaggtac 480
acgttagtga tataaaaaga aggcgacgac g 511
<210> 221
<211> 146
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 221
gatgtggaag gtcacagcct cgttggagga gatactacgg tcccgctttt cgtgggtgac 60
aaaggtcgca aaggtttcct tagggaggtc gtttcccgga tctttatcta catctcctgg 120
gtgaagggga tgatctttct ctacat 146
<210> 222
<211> 81
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 222
gagaagatga caaagtagaa gctagacaac tatatcaaat cgttgtgtgg tcttaaaccg 60
acacagtagc attcatcgtt g 81
<210> 223
<211> 163
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 223
gagaaacttg tctactggca gacctcacta tcttttagga aggtcacgaa gcggctggag 60
tgatggctag tctcagccac tgtcaacggg aagcgcgacg tttatggtca atataaacta 120
gcagtttaat ccgtatggcg atcttagcgg atgttacagg atg 163
<210> 224
<211> 131
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 224
gagtgttgta ttaattcact ctagagtaat ggatcacggt gccagaaact aaggtggtgt 60
aggactagat gcaagtaaca acggtcgtac taaaatcagc tacgcgatcg ccgacttaga 120
aggctgagat g 131
<210> 225
<211> 64
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 225
gatgtgaaaa tgtcatatgt gcggcaaaaa tagacgacat ttaagaacct agcattatag 60
gatg 64
<210> 226
<211> 125
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 226
gaacacagat attgcagaag cgggaatgag gttgatatta catcaagtat caacagacga 60
cctcagaagg gtggtctttt aaaatgacaa cgtacattaa gatgcagaca aacactacta 120
tgctg 125
<210> 227
<211> 58
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 227
gattacgacg ccaagccact ataaatgcta attgagtcga agaaggtact cctttttg 58
<210> 228
<211> 83
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 228
gatctaagat gactacagta gcatagccat agaacatggc actgaaatat cgatgggcgt 60
aaaagtgaac aacgcagacg atg 83
<210> 229
<211> 70
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 229
gaaatcgcat cgacacaata aaagtacacc aaccagcaga aaacaggtac atatacagtt 60
taacgacctg 70
<210> 230
<211> 160
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 230
gaaccaagca gtgggcgatg tcagcgacaa ttccactttg gtagaggtcg ttcttttgta 60
gaaaacaatc taacataact atgacacttt cggtaaattc accaccttta ccagggtcgt 120
aagtggtcaa gccacgccga ccacttcata agcattggtg 160
<210> 231
<211> 115
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 231
gaaccaagca gtgggcgatg tcagcgacaa ttccactttg gtagaggtcg ttcttttgta 60
gaaaacaatc taacataact atgacacttt cggtaaattc accaccttta ccagg 115
<210> 232
<211> 106
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 232
gatcgtttgc ccgtaaaact aactggcaaa agcctaagtg ctgtttcggg tgcaatggta 60
taacttccca catttagccg aatagcgcca acagcgttat tatttg 106
<210> 233
<211> 93
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 233
gtagaccttt ccttgccgcg tggaacaaac cgccatgagt gttttacgtt tacggtcggc 60
gaccggagtc acagcgcgac caacggggcc agg 93
<210> 234
<211> 121
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 234
gcccatgaat tacccgctta ggcaatgggt agacctttcc ttgccgcgtg gaacaaaccg 60
ccatgagtgt tttacgttta cggtcggcga ccggagtcac agcgcgacca acggggccag 120
g 121
<210> 235
<211> 122
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 235
ggcccatgaa ttacccgctt aggcaatggg tagacctttc cttgccgcgt ggaacaaacc 60
gccatgagtg ttttacgttt acggtcggcg accggagtca cagcgcgacc aacggggcca 120
gg 122
<210> 236
<211> 130
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 236
gacttgtagg cccatgaatt acccgcttag gcaatgggta gacctttcct tgccgcgtgg 60
aacaaaccgc catgagtgtt ttacgtttac ggtcggcgac cggagtcaca gcgcgaccaa 120
cggggccagg 130
<210> 237
<211> 141
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 237
gcatactgca agacttgtag gcccatgaat tacccgctta ggcaatgggt agacctttcc 60
ttgccgcgtg gaacaaaccg ccatgagtgt tttacgttta cggtcggcga ccggagtcac 120
agcgcgacca acggggccag g 141
<210> 238
<211> 135
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 238
gcatactgca agacttgtag gcccatgaat tacccgctta ggcaatgggt agacctttcc 60
ttgccgcgtg gaacaaaccg ccatgagtgt tttacgttta cggtcggcga ccggagtcac 120
agcgcgacca acggg 135
<210> 239
<211> 218
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 239
gagcgttagt cggcgcgtgc gcgggactat ttagcgaagg tcgccgtatc gcgggtggcg 60
gcgtttccgc cataacaaca agcgtttaag gtcagagtcc gcgacgaatg aaacgccgtg 120
caagcggctt tggtacggcc agtttagcca aagcctgatc cgttcgcctt gggttatcat 180
gtaccagtca agcggtcatc gcgggcggcg ttatcatg 218
<210> 240
<211> 51
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 240
gagcgttagt cggcgcgtgc gcgggactat ttagcgaagg tcgccgtatc g 51
<210> 241
<211> 229
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 241
actttccagt tagtcgccgt cctatattgg caagaccgga tggccgtcaa ccagttccat 60
tctgactatt tgccacattg attaaagaag taggagcgtt agtcggcgcg tgcgcgggac 120
tatttagcga aggtcgccgt atcgcgggtg gcggcgtttc cgccataaca acaagcgttt 180
aaggtcagag tccgcgacga atgaaacgcc gtgcaagcgg ctttggtac 229
<210> 242
<211> 202
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 242
gtgttaggtg caatccccat tcgggacgga cacgcgagta aaggtctaac atgtttcaac 60
tttccagtta gtcgccgtcc tatattggca agaccggatg gccgtcaacc agttccattc 120
tgactatttg ccacattgat taaagaagta ggagcgttag tcggcgcgtg cgcgggacta 180
tttagcgaag gtcgccgtat cg 202
<210> 243
<211> 38
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 243
gtgttaggtg caatccccat tcgggacgga cacgcgag 38
<210> 244
<211> 412
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 244
gcaaaggccc ataggctttt ccatcggcac gcgaccgatt ccatcaagta tagccacggt 60
cgtaacttcg acggcggcaa tagtttatgg cgctaacacc tttccatcgc tgagtccaaa 120
cgtatgacgt gaggtgttag gtgcaatccc cattcgggac ggacacgcga gtaaaggtct 180
aacatgtttc aactttccag ttagtcgccg tcctatattg gcaagaccgg atggccgtca 240
accagttcca ttctgactat ttgccacatt gattaaagaa gtaggagcgt tagtcggcgc 300
gtgcgcggga ctatttagcg aaggtcgccg tatcgcgggt ggcggcgttt ccgccataac 360
aacaagcgtt taaggtcaga gtccgcgacg aatgaaacgc cgtgcaagcg gc 412
<210> 245
<211> 417
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 245
ccagagcaaa ggcccatagg cttttccatc ggcacgcgac cgattccatc aagtatagcc 60
acggtcgtaa cttcgacggc ggcaatagtt tatggcgcta acacctttcc atcgctgagt 120
ccaaacgtat gacgtgaggt gttaggtgca atccccattc gggacggaca cgcgagtaaa 180
ggtctaacat gtttcaactt tccagttagt cgccgtccta tattggcaag accggatggc 240
cgtcaaccag ttccattctg actatttgcc acattgatta aagaagtagg agcgttagtc 300
ggcgcgtgcg cgggactatt tagcgaaggt cgccgtatcg cgggtggcgg cgtttccgcc 360
ataacaacaa gcgtttaagg tcagagtccg cgacgaatga aacgccgtgc aagcggc 417
<210> 246
<211> 54
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 246
ccagagcaaa ggcccatagg cttttccatc ggcacgcgac cgattccatc aagt 54
<210> 247
<211> 110
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 247
gaggaagcct tttagccatc gctatgccgc cgctcaaacg cgccgggtgc aaaagcccag 60
agcaaaggcc cataggcttt tccatcggca cgcgaccgat tccatcaagt 110
<210> 248
<211> 557
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 248
agctgctcgc atgaccagct atatctggaa catcgctggt gggtcttatg gtcgcttttg 60
tgggaaccat catagtcgca agtctggcct tcggtatgga actcgtcgtc ccgactacaa 120
ccatagctag tctcggtctc ggctttgttg caatgccctt cgttactact tcaacggtcg 180
tggtgccggt caaaccgctc gctaaagcaa gcgaagaaac agctaaactt agttgtgtcg 240
aaacatccta agtggtcggg ttgctcgtgg agcatgcagc tagcccagaa cctttagctt 300
gtgtggtctt cgtctcggta gtcagaacca ggtcggtctg aatggttgga ctcgccacat 360
caactaggtc agctattgaa gtgccaacta aaggtcgtat tgaagcaatc ggtcctatgg 420
caagtcaagt gacagtcgta ggtatggcac ttgccgcgcc tccagaactc ggtcaagcta 480
cctcataact cggaagtcga ctgctctaaa gcgaagttgt caaacgaaca gctatgcctt 540
cgagtaaagc aaggtgc 557
<210> 249
<211> 2473
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 249
gtccacgctc taagtcgctt gcccaattgt ggctaccgca ttgctcagaa cttcgggtac 60
tggccaacct tcaagaagcc tagtcttggt gcgtcacccc agtcacgtag catacccgtc 120
atcatctatg gtcgtaggtc caacaatcgt ggcgccattg ggtaccactt catcagagct 180
gctcgcatga ccagctatat ctggaacatc gctggtgggt cttatggtcg cttttgtggg 240
aaccatcata gtcgcaagtc tggccttcgg tatggaactc gtcgtcccga ctacaaccat 300
agctagtctc ggtctcggct ttgttgcaat gcccttcgtt actacttcaa cggtcgtggt 360
gccggtcaaa ccgctcgcta aagcaagcga agaaacagct aaacttagtt gtgtcgaaac 420
atcctaagtg gtcgggttgc tcgtggagca tgcagctagc ccagaacctt tagcttgtgt 480
ggtcttcgtc tcggtagtca gaaccaggtc ggtctgaatg gttggactcg ccacatcaac 540
taggtcagct attgaagtgc caactaaagg tcgtattgaa gcaatcggtc ctatggcaag 600
tcaagtgaca gtcgtaggta tggcacttgc cgcgcctcca gaactcggtc aagctacctc 660
ataactcgga agtcgactgc tctaaagcga agttgtcaaa cgaacagcta tgccttcgag 720
taaagcaagg tgcgcaatag taaccttggt aacttcggaa ctgcgtcaag ccgctaactc 780
catcggtatg gaagtcgcta aagtcggtca aacggaagcg gctatcgtcg caactagtcg 840
aatagttgtc gaagaggcca gagcaaccat ggttgccatt gtcttcgtgg tctatgcaag 900
acgtccttgc gtcatggcct aagcatcttc ttcactggtt gctatagcgg aagtcgttac 960
cgaactggtc gccagtcgaa tcgtttgccc catggtagtc atcaccacca tcgcggaaac 1020
caacggtccg aactcacggt aggtagtcca cgtatgtagc ccacctttcg aaggaatcgt 1080
ggtcgccggt ctcctagaaa cggtatatgt cttgcgtcac gcttatggac cggtcatcct 1140
ggccagtagc cgacttgtgg tcgctatagc tttcgctagt ccctgcctta acgtgcagca 1200
tggtatggct attgtcgtcc cggctacaac cactatcgtg gtcttgaaac tggtcgtcgc 1260
tacaaccatc ctagcattgg caccagcggt cgttgaagcc gaaggtagtc tctaactggt 1320
tttcgaagct agtcaaacag tagcgccata tggcctagcc tgaaccttag aaaaaggagt 1380
cgaaggtcct aaacccgctg gtcgcgaacg aacaaaaacg gtcgttaaag gccgtccgga 1440
agcggaaggt cgtcgcccca ggtgaacaag tcctaaagaa acaaaaagtc tctgtagtct 1500
atttaaaacc caacgcaaac gcgaacgcag aatcgtctga acccacgtcc atcattacgg 1560
attatataag gtttctgttt cgttaactag gtagttattg atgtcatccg cactacaagc 1620
taacaggagg taacagatag agcatgagtg gtagtaggga tgaaacagga agtactaatt 1680
acatacaggg actcctggtt gggtgacccc gggacacgta cgtgtcctaa taaacaggag 1740
gcgggtggtt tcctatctac tacggacagg gattttcccc gagtagcgaa ggatatgaaa 1800
cttctagtta tagacatata agacgtagtc caggaagtcg gctgagtcca tgaggtcagt 1860
tttggaggag aagtagttgt cacgatcctt agttaagata acaaagtccg agtagttatc 1920
acgacttgct gactgcgtcc actatgtttc cggggtgggc atggggactt gcacacggat 1980
aactccatcc ggattattaa gacgaggtgg ggtgtgctgg gctcccagga acttcatcgg 2040
agtgacgtag aaccttcagt ttgagtccac gtaggacacc agcgctattg gtgccgacga 2100
cgagtacaaa catccggaaa cttagcatat taggtaagag tttctgtatg ctcggacgtc 2160
gtcgttagag cagacccaga aggtgtccat ggacacacat catacaagac aacttggtca 2220
acttttacgg ggctggggcc aattatcccg ggagtcctca cgatcagaaa ccgactggtt 2280
tgtcacactc tggttagagg aggggtcacc acgatgggtg agggggtggt gggtgtttat 2340
acaagagtct gggactccaa agacgatatt acgacgagac gacttatcca cgtactttgt 2400
ttcccaaacc cacgcaactc cacctttagt ccacacaaac tagtacgaga cacccggatt 2460
caaggtcgtg acc 2473
<210> 250
<211> 734
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 250
gtccacgctc taagtcgctt gcccaattgt ggctaccgca ttgctcagaa cttcgggtac 60
tggccaacct tcaagaagcc tagtcttggt gcgtcacccc agtcacgtag catacccgtc 120
atcatctatg gtcgtaggtc caacaatcgt ggcgccattg ggtaccactt catcagagct 180
gctcgcatga ccagctatat ctggaacatc gctggtgggt cttatggtcg cttttgtggg 240
aaccatcata gtcgcaagtc tggccttcgg tatggaactc gtcgtcccga ctacaaccat 300
agctagtctc ggtctcggct ttgttgcaat gcccttcgtt actacttcaa cggtcgtggt 360
gccggtcaaa ccgctcgcta aagcaagcga agaaacagct aaacttagtt gtgtcgaaac 420
atcctaagtg gtcgggttgc tcgtggagca tgcagctagc ccagaacctt tagcttgtgt 480
ggtcttcgtc tcggtagtca gaaccaggtc ggtctgaatg gttggactcg ccacatcaac 540
taggtcagct attgaagtgc caactaaagg tcgtattgaa gcaatcggtc ctatggcaag 600
tcaagtgaca gtcgtaggta tggcacttgc cgcgcctcca gaactcggtc aagctacctc 660
ataactcgga agtcgactgc tctaaagcga agttgtcaaa cgaacagcta tgccttcgag 720
taaagcaagg tgcg 734
<210> 251
<211> 133
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 251
gatagtagac cgggaagacc aacgtttttt cactactccg aaagaacaca ctgaagggaa 60
cggtgtaggt tcggtgagtc cgggactagg tgtccatgtc ggagacctca gtggtgacgt 120
cctcgtagta tag 133
<210> 252
<211> 132
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 252
gatagtagac cgggaagacc aacgtttttt cactactccg aaagaacaca ctgaagggaa 60
cggtgtaggt tcggtgagtc cgggactagg tgtccatgtc ggagacctca gtggtgacgt 120
cctcgtagta ta 132
<210> 253
<211> 50
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 253
caaacgatgt cttgaacaac accgtcttca ttgtttacca tttgctgttg 50
<210> 254
<211> 49
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 254
caaacgatgt cttgaacaac accgtcttca ttgtttacca tttgctgtt 49
<210> 255
<211> 31
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 255
gcaattagga tcaggtggtt aatctgatac g 31
<210> 256
<211> 118
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 256
ggaggacatg cacctagttg aacacgacta ggaggacgat ggccactacg gagtggaaca 60
caaaggtaaa gttgcaataa taaccagtac aacaaaagca tacgtggaag gtgacaag 118
<210> 257
<211> 361
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 257
gaatgtatgt aattattcgc aagggttcca taaggcacat atacaaattt agaaacaacc 60
cgttacatta acaaaggtga acggtgtttc acagatatta gaccattagg taaccaatga 120
catttcacta tcgaaaaggg tatagtatta actactacaa ctaatccgac tcgtcgaggt 180
gatttataca ggactgcagg tagcaaacga cgaggtggac gagggtaagg tggccgacga 240
aagggaggac atgcacctag ttgaacacga ctaggaggac gatggccact acggagtgga 300
acacaaaggt aaagttgcaa taataaccag tacaacaaaa gcatacgtgg aaggtgacaa 360
g 361
<210> 258
<211> 145
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 258
gaatgtatgt aattattcgc aagggttcca taaggcacat atacaaattt agaaacaacc 60
cgttacatta acaaaggtga acggtgtttc acagatatta gaccattagg taaccaatga 120
catttcacta tcgaaaaggg tatag 145
<210> 259
<211> 110
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 259
gtgaaaggtg atacatattt acttgacttc ttaagcagag agcgtcaaaa caggttgaac 60
ttatacagaa atactaaaag tcgaacaacc attcgattta ggaatacaga 110
<210> 260
<211> 151
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 260
gatacagaac aactaaaaga actaaaagag aagaacgacg tgcacgtgct aattatgcga 60
attaacatcg ggttagaaaa agtaaactaa aggaaaatgg gtaaggcata tgccttacta 120
aattgtgtaa aagaagttct aataagaacc g 151
<210> 261
<211> 156
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 261
gtgcagatac agaacaacta aaagaactaa aagagaagaa cgacgtgcac gtgctaatta 60
tgcgaattaa catcgggtta gaaaaagtaa actaaaggaa aatgggtaag gcatatgcct 120
tactaaattg tgtaaaagaa gttctaataa gaaccg 156
<210> 262
<211> 346
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 262
caccaccgga gggttgctag accctaacgt gggagacgct ctatccacag ctacatcatt 60
cagaagagaa agaagagggt cttctacagg ggacattgca gctaacacgc tggttgttcg 120
ttgcgtagac gacacttgtt ctgtcgctac cgaggcaagt aaagtcgcca acgtagtatc 180
gccaatggta acagtagcaa tctgtcattc accacgcgaa ctggactatg tttaaatccc 240
tttgccaatc ttccctattg tcccgtcaac ttccttctgt cttgctttgg taagtgtcaa 300
cgtggcctga ccgaatatca cattcagaac agttgctatg ctacac 346
<210> 263
<211> 265
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 263
gccaaggtga accaggacga agtcgatgtt tcagaacctc ctttaggcct tttagacggt 60
ttaaacgaag cactagacca agtaataaaa gcggacgttg cacaggtacg tgcagataca 120
gaacaactaa aagaactaaa agagaagaac gacgtgcacg tgctaattat gcgaattaac 180
atcgggttag aaaaagtaaa ctaaaggaaa atgggtaagg catatgcctt actaaattgt 240
gtaaaagaag ttctaataag aaccg 265
<210> 264
<211> 430
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 264
ctagcgcgtc cgtcaacttc acactggttc cgtagtccta acgttgtagt ctgtgcagat 60
gaagaacgag gtcaacaacg aggtcacgta tgagataccg tcggtagtcc atgacacccg 120
aaaggtcacg tcaactaagc aattgaagtt gcaattacct cttcggtact ggaaattggg 180
cacccaacca agcgaaccga aaccacactc gttacggtgg ctcgtcgttg acgacctgct 240
ggtaaagcag aaggtacgcg aagttaacga accagaccaa gtatcggtcg aatccgaatt 300
gtcttagtta cagtgggact tgcagtacga cgtatcgttg ccacaatgcc cgttattgtc 360
accacagcta atggtgaacc aagaacagcc agactcatgg tcaacgtaat ccactgactg 420
ggccacgatc 430
<210> 265
<211> 208
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 265
ctagcgcgtc cgtcaacttc acactggttc cgtagtccta acgttgtagt ctgtgcagat 60
gaagaacgag gtcaacaacg aggtcacgta tgagataccg tcggtagtcc atgacacccg 120
aaaggtcacg tcaactaagc aattgaagtt gcaattacct cttcggtact ggaaattggg 180
cacccaacca agcgaaccga aaccacac 208
<210> 266
<211> 520
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 266
gacggttaaa gttattgact tatgttagca tgtgcaaatt aacataggct agtcttaacc 60
tgactcgctg tcgcgactgg catgcaaagt ttgacacgcc gcggctctag tacgcgtcat 120
ctttcagctg taataactac aaacacatca aaaaaagtcg gtttaaaaca acttgtgaaa 180
cgtcaacttg gtaaataaac ctattattaa agaatctaga tcaatgtcca aaaagattat 240
ttccattgtt acgtctaaat acagattctg cgaaaacaag ccattagtat agtagaagaa 300
ctaaccatcg tatgttcgtg aacgtcgagt caaagtggct acatgaacaa cgattgccac 360
aagcatggtc agtgtcagac ttctagcttc atcgggtcgt ctaagagtgg aaagtccatg 420
acgagcaatt ggaatggcaa tttgaagagg tactcttccg acagttggag tggtctccgc 480
ctttgccgtt gtaaccaatc caataaaccg catctgtaaa 520
<210> 267
<211> 1019
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 267
cctgtttcta gcatgtataa caaaattaag cgacgaccga gcgacgacaa caagcagcag 60
ccaggtgggc aaaaggctaa gactgctttg atgtcctgag ccaacttgcc gatacgcagc 120
aacattttag aaacgtcatc ctgaccgccg ccgccattgc cataaatgat agcttggcgg 180
tagccgccca aaactatgaa aaaaattaaa ttaaggaaag acataaacaa ggtagttaag 240
ccatgcacct agaaaatttt gaacggctca gctgcaacat attagcgcta gaaatgacct 300
accataatga tatagaagat aattaccatt actgccaccg cctcctccgc tgccgcctcc 360
tccatagcag cttctattca aacaaactcc gccgccgcca ccgccgccat aaccaccacc 420
ataaccaccg ccgtatacac aaacgccgct ccttctaagt cttagctatt aataacaacc 480
gtggaaacaa aaaacgtaat ataggctaca gctgtgtcaa cagccaaatc cataacaaca 540
aaatccatgg tgactgtaac agacactgtt acaaccatat tattaactag atagtggtta 600
cagataatca tgcagcaaca acatataaag aagacggtta aagttattga cttatgttag 660
catgtgcaaa ttaacatagg ctagtcttaa cctgactcgc tgtcgcgact ggcatgcaaa 720
gtttgacacg ccgcggctct agtacgcgtc atctttcagc tgtaataact acaaacacat 780
caaaaaaagt cggtttaaaa caacttgtga aacgtcaact tggtaaataa acctattatt 840
aaagaatcta gatcaatgtc caaaaagatt atttccattg ttacgtctaa atacagattc 900
tgcgaaaaca agccattagt atagtagaag aactaaccat cgtatgttcg tgaacgtcga 960
gtcaaagtgg ctacatgaac aacgattgcc acaagcatgg tcagtgtcag acttctagc 1019
<210> 268
<211> 468
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 268
cttgttccaa tcggcccggc ttcagtcatt cccggtggcg aagccatgtc accaataaaa 60
actatcggcg gcaatggaag tggtttttcg gaaactgtta cgggtgcaag cggccccagt 120
gcagtttgtg ccttgccaat cggcccagct ttcaaacgca aagttggacg acttattggc 180
ccattctgac aacgtcctgt taaactgccc ggacgttcaa acggcggtat cggacgacta 240
acgcgttacg gcggacaact cgcccccagt caacaacttg gacacggtaa atttgaacgc 300
taagtcaact gtagcagtta aacattgagt attaaaatag atttaagcta gcgttaagaa 360
cattaaaaac taaccagcca aaccaaggat tacggctgtg gtgtaatcga ttgcgaaata 420
gcatgacaaa aaacttacag tttagaaggt ggcggtatta cttaagaa 468
<210> 269
<211> 151
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 269
gacatcagat gttaatgacc taacgattat agtgctgaac aacgtctacg acaatataaa 60
cctttgcaaa gactggtcaa acatcaatgt taaacacgtc cagataaaag caaaaaggta 120
agacgaggat tacggaataa ttaatatagt g 151
<210> 270
<211> 247
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 270
gaaacaagct atgctaatgt tgaccatttg gctcttcgac cagcagtcag ccgcttcttt 60
acctgccaac gttgttcata acaggcaaaa ccagaaagtc gcataggttg gtcaactttc 120
gcagaaccaa ctgttactgc gatcttcagc ttgccttttg tcccagatta acgtgtaatt 180
attaaacaaa gttcggcagt tccagtcgct atcgacaaaa ccgaaaccac aagttctgta 240
attacgc 247
<210> 271
<211> 509
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 271
cattcgttca acatgaagtg gcttatgttc gcggagtagt agcgcgtaaa agtgtaggta 60
cgcgagctat cgtgcggtgt agcatcgcag tcaaagcttg cgtaggtagc gttgcaatct 120
cctgtactaa agacatgcaa ctgccagctt gtactgttgg cgaagaaagt tcagtggatg 180
ttactaaccg cgtttaacgc gtggacacgg cggcagttga gccaatcgat tacgaaacaa 240
gctatgctaa tgttgaccat ttggctcttc gaccagcagt cagccgcttc tttacctgcc 300
aacgttgttc ataacaggca aaaccagaaa gtcgcatagg ttggtcaact ttcgcagaac 360
caactgttac tgcgatcttc agcttgcctt ttgtcccaga ttaacgtgta attattaaac 420
aaagttcggc agttccagtc gctatcgaca aaaccgaaac cacaagttct gtaattacgc 480
gttcggcaaa gcgcaatgcg ccctaatac 509
<210> 272
<211> 135
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 272
gtggttaggt cgcttggtag catatctgtt accgaagaca cgacagtaaa ttgtcaagca 60
aacactgcgc cttcttcggt cgcataaaga agtgaaccat aacgttctcc tacttaactc 120
cgcaacgaaa aagag 135
<210> 273
<211> 110
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 273
gtggttaggt cgcttggtag catatctgtt accgaagaca cgacagtaaa ttgtcaagca 60
aacactgcgc cttcttcggt cgcataaaga agtgaaccat aacgttctcc 110
<210> 274
<211> 178
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 274
acatttgatt cgttgacgta tttatgttga ttcggttagc gagagttaca aagttagtaa 60
tagaaagaaa gaggaaataa taatcaaaag attaagcatg caaacattaa gaggacacat 120
atgtattggt ggcatttgcg ttaggttaac gtctcgtaag acggtgaagc tgcttaaa 178
<210> 275
<211> 216
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 275
ttacgatccg aaatttcatg gacacagata tttgagatca acatttgatt cgttgacgta 60
tttatgttga ttcggttagc gagagttaca aagttagtaa tagaaagaaa gaggaaataa 120
taatcaaaag attaagcatg caaacattaa gaggacacat atgtattggt ggcatttgcg 180
ttaggttaac gtctcgtaag acggtgaagc tgctta 216
<210> 276
<211> 185
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 276
gattacgatc cgaaatttca tggacacaga tatttgagat caacatttga ttcgttgacg 60
tatttatgtt gattcggtta gcgagagtta caaagttagt aatagaaaga aagaggaaat 120
aataatcaaa agattaagca tgcaaacatt aagaggacac atatgtattg gtggcatttg 180
cgtta 185
<210> 277
<211> 182
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 277
gattacgatc cgaaatttca tggacacaga tatttgagat caacatttga ttcgttgacg 60
tatttatgtt gattcggtta gcgagagtta caaagttagt aatagaaaga aagaggaaat 120
aataatcaaa agattaagca tgcaaacatt aagaggacac atatgtattg gtggcatttg 180
cg 182
<210> 278
<211> 92
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 278
aaagaagatg cacttagtgc cattattatt agacaagata gtccgttctt tagtcgaagt 60
tcttgttgta ataacaaaag tagagcagta tt 92
<210> 279
<211> 232
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 279
gtttcaacaa tgcccaagtt gacattattc caaaacgttt cgtagaaatg aaagcgcttc 60
gagtaattag gcgcaaactt acaggacgcc atggcatatg ggtggtagaa ccaacgatgg 120
aagcgagtag cgcaatgcct tagcgcacgc ctacactaac tgcttacgaa gttggagcaa 180
aagaaactga acgtgtcagc caaaattgcc aagaaacagg agctaccaaa ag 232
<210> 280
<211> 116
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 280
catcgtacga actttgacaa cgaaaggttc aaaggtaacc aaggcgtagt agtgagttag 60
gtcaatgtat aaaaactccc tttcttattt tgagtcgtca atgtagtcga gaaagt 116
<210> 281
<211> 96
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 281
tattgttata ggcggtatat tggtaaatga cgatccttga cttagttttt tacatcgaac 60
ggttgcaaat cctagcatac ttgatattaa tagtag 96
<210> 282
<211> 2235
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 282
gagtaaacga acatccaaca gtatgtacaa tcgtatgaga aaggacaaat ctgaagacga 60
tattagaggg agtccaacaa gtttgtgatg attcacgtaa ggaaatcgaa atgtaagatt 120
attcgtcaat ggaggtataa gacaacacac caagtaatta tacgcgacga gttttcatgt 180
tgacgatccc tgagactata tcatacaaaa ttgacccaaa taataaactc gttccaatag 240
ttgaagtgtt gattaacaca ttgagacaag ttgtccgtac tttaatcatc aaagttttgg 300
actgacctat aaatgaaata ttcgcgttgt cttcagttta agaagtgata ttattttcgg 360
tttcaagcct atgtggagag atacaggaaa taggtaaact ataactaata taaatatacg 420
cagacgaagc ctgttaactt taccaaatcc aaatagcggg agacactaaa cttacaagaa 480
atgtacggta agacagggaa acagggtttg aagtttggag gtacaaaatc ttaatccttc 540
acaactgaat caacatttac attcggttac gttcggggtt tgtagtagta attgttgagg 600
taattttaat tgcacttaca gacgtggatt tggtgaaaca ttatgtggta gattcatatt 660
tccgaatctt aatagacgat tttatgatgg tgatcgtggt ttcttttcaa ggtttggtgg 720
acgaaaatga aaaaatcaca atttaacgtt tcatattcat cacaatccga aatcgagatg 780
gagagaaagt ttgactaaac tttgttacag tatttttgaa ggcaatcaac ctggaacttt 840
ggatttcatc aagtaaacac ccatatttag cgaaaatgca agctaactgc gaactaacaa 900
ggtaactctt tttcgatttc aaaatatggt cagtagcaat atgttaagtg atccattttg 960
gaggggtggg gatttgttca atgaatgagg caataaacca ccgcaacctc tgtaattgac 1020
gagaaacttg tataaggtca tcaaaaagaa tagatgaaca taaagattga atacggctgg 1080
gtgaggttaa ttcagatttc ccaaattatg tagatgaaaa gatggtaagt ttattgatag 1140
gtaaaaaatc aagagagggt aataaagaag aaagaataat caaaagatag agcatgcaaa 1200
cattacatgg tagtattgtt ataggcggta tattggtaaa tgacgatcct tgacttagtt 1260
ttttacatcg aacggttgca aatcctagca tacttgatat taatagtaga tactgaaata 1320
tatctgagta tatcaaggga aatcgagatg taacaataag tcgaggaaat taaggtcaat 1380
ttagtgctta tcatagaaat aactacttaa gcccttaacg aactaactca aattaacgag 1440
gtagaggtta ttctgaattg tacgaacgta gtcgaagttt gttaccaagg gtaaagccaa 1500
aacaaaacga tttgacaaga gaatctattc catgtagtag tgcgtttgta cgacgttcta 1560
ttcgatgtaa atcattagga cgagggtttg aagcaactcg gaaagatggt cggttagaat 1620
ttaaaagtac tgaacggaat taacgaagtt ggctactacc taatagtctt tgcttaggat 1680
ttagtagttc gcaattgggt caaagtggtc gctttggtcg tcgacgtcaa gactcaacaa 1740
gtcatttacc gctgtacgaa ccatctcatt taacaggttc tcaaccaaat agcggtagga 1800
gtagaaagca cttaccatcg tacgaacttt gacaacgaaa ggttcaaagg taaccaaggc 1860
gtagtagtga gttaggtcaa tgtataaaaa ctccctttct tattttgagt cgtcaatgta 1920
gtcgagaaag tgtccaagca aaacgtaacg aaacggttga gtaaggactt gcacactatg 1980
cccttgcggg tttacctgct tgacgtagtc ctgccactta ttatccgtga ttgttaccta 2040
atggacaacc taatcgttag cttaaagaag atgcacttag tgccattatt attagacaag 2100
atagtccgtt ctttagtcga agttcttgtt gtaataacaa aagtagagca gtattttgac 2160
gtatagggag acagtcatta ggtcattaac ccagttacta aggacaacgt aaccatcgaa 2220
gttattgaac ttcag 2235
<210> 283
<211> 1765
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 283
gagtaaacga acatccaaca gtatgtacaa tcgtatgaga aaggacaaat ctgaagacga 60
tattagaggg agtccaacaa gtttgtgatg attcacgtaa ggaaatcgaa atgtaagatt 120
attcgtcaat ggaggtataa gacaacacac caagtaatta tacgcgacga gttttcatgt 180
tgacgatccc tgagactata tcatacaaaa ttgacccaaa taataaactc gttccaatag 240
ttgaagtgtt gattaacaca ttgagacaag ttgtccgtac tttaatcatc aaagttttgg 300
actgacctat aaatgaaata ttcgcgttgt cttcagttta agaagtgata ttattttcgg 360
tttcaagcct atgtggagag atacaggaaa taggtaaact ataactaata taaatatacg 420
cagacgaagc ctgttaactt taccaaatcc aaatagcggg agacactaaa cttacaagaa 480
atgtacggta agacagggaa acagggtttg aagtttggag gtacaaaatc ttaatccttc 540
acaactgaat caacatttac attcggttac gttcggggtt tgtagtagta attgttgagg 600
taattttaat tgcacttaca gacgtggatt tggtgaaaca ttatgtggta gattcatatt 660
tccgaatctt aatagacgat tttatgatgg tgatcgtggt ttcttttcaa ggtttggtgg 720
acgaaaatga aaaaatcaca atttaacgtt tcatattcat cacaatccga aatcgagatg 780
gagagaaagt ttgactaaac tttgttacag tatttttgaa ggcaatcaac ctggaacttt 840
ggatttcatc aagtaaacac ccatatttag cgaaaatgca agctaactgc gaactaacaa 900
ggtaactctt tttcgatttc aaaatatggt cagtagcaat atgttaagtg atccattttg 960
gaggggtggg gatttgttca atgaatgagg caataaacca ccgcaacctc tgtaattgac 1020
gagaaacttg tataaggtca tcaaaaagaa tagatgaaca taaagattga atacggctgg 1080
gtgaggttaa ttcagatttc ccaaattatg tagatgaaaa gatggtaagt ttattgatag 1140
gtaaaaaatc aagagagggt aataaagaag aaagaataat caaaagatag agcatgcaaa 1200
cattacatgg tagtattgtt ataggcggta tattggtaaa tgacgatcct tgacttagtt 1260
ttttacatcg aacggttgca aatcctagca tacttgatat taatagtaga tactgaaata 1320
tatctgagta tatcaaggga aatcgagatg taacaataag tcgaggaaat taaggtcaat 1380
ttagtgctta tcatagaaat aactacttaa gcccttaacg aactaactca aattaacgag 1440
gtagaggtta ttctgaattg tacgaacgta gtcgaagttt gttaccaagg gtaaagccaa 1500
aacaaaacga tttgacaaga gaatctattc catgtagtag tgcgtttgta cgacgttcta 1560
ttcgatgtaa atcattagga cgagggtttg aagcaactcg gaaagatggt cggttagaat 1620
ttaaaagtac tgaacggaat taacgaagtt ggctactacc taatagtctt tgcttaggat 1680
ttagtagttc gcaattgggt caaagtggtc gctttggtcg tcgacgtcaa gactcaacaa 1740
gtcatttacc gctgtacgaa ccatc 1765
<210> 284
<211> 277
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 284
gagtaaacga acatccaaca gtatgtacaa tcgtatgaga aaggacaaat ctgaagacga 60
tattagaggg agtccaacaa gtttgtgatg attcacgtaa ggaaatcgaa atgtaagatt 120
attcgtcaat ggaggtataa gacaacacac caagtaatta tacgcgacga gttttcatgt 180
tgacgatccc tgagactata tcatacaaaa ttgacccaaa taataaactc gttccaatag 240
ttgaagtgtt gattaacaca ttgagacaag ttgtccg 277
<210> 285
<211> 276
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 285
gagtaaacga acatccaaca gtatgtacaa tcgtatgaga aaggacaaat ctgaagacga 60
tattagaggg agtccaacaa gtttgtgatg attcacgtaa ggaaatcgaa atgtaagatt 120
attcgtcaat ggaggtataa gacaacacac caagtaatta tacgcgacga gttttcatgt 180
tgacgatccc tgagactata tcatacaaaa ttgacccaaa taataaactc gttccaatag 240
ttgaagtgtt gattaacaca ttgagacaag ttgtcc 276
<210> 286
<211> 202
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 286
gatagtaaaa gtcgaaatct ttatattcgg ttcgatgtac tacgttattc gcgactgttc 60
tgtcatgata gttttttata tagtcctaat aaaaggagtt tttaaagtaa atgacatttc 120
agtagtaaaa gtttaagagc tttttgttct gccagacgtt ctgatagttg aggaaaacgt 180
gtggtcagct aataacttgt gg 202
<210> 287
<211> 211
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 287
gattagatag taaaagtcga aatctttata ttcggttcga tgtactacgt tattcgcgac 60
tgttctgtca tgatagtttt ttatatagtc ctaataaaag gagtttttaa agtaaatgac 120
atttcagtag taaaagttta agagcttttt gttctgccag acgttctgat agttgaggaa 180
aacgtgtggt cagctaataa cttgtggtat g 211
<210> 288
<211> 77
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 288
gtacgaatta cgaacacctt aacattaggg aaacttagat agttgtacaa agtaacgtat 60
aacaagtatc gcgtatg 77
<210> 289
<211> 167
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 289
atgacgagaa gcatttcaag aaagcgttgt agcttaaaaa gaacgttgcg gtgctaaagg 60
agaaagtcga aaaagcgaag gagttaaaac aaaagccggt tattaaatgc tggaagaagg 120
aagaacaaca actaaacaag gttgtcaaga gcattaagga agccgta 167
<210> 290
<211> 42
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 290
gataccgaat ttagaggcca taggttatgg aaaaagtcag tg 42
<210> 291
<211> 61
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 291
gtggagaagc aaatacttgg ataccgaatt tagaggccat aggttatgga aaaagtcagt 60
g 61
<210> 292
<211> 80
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 292
tggccaaaca acactcgcaa agaatttatg tgcgcttggc aggtggagaa gcaaatactt 60
ggataccgaa tttagaggcc 80
<210> 293
<211> 661
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 293
gttaccatgt aagaagcggt agacgccatg gcctagtagg aagaatgctt gttcacggag 60
ccgacgaagt tagacgagtg gcagaagaaa gagcattatc ttggtactcg gactgaatgc 120
gtactacggt cgtccaagtt gcaagaggta ttagagtcat tcgaatagct gtgggagtgg 180
tatttatagc ataataagtg taaaaaacat tcccaacagc atatgtgtag ccaagaagcg 240
ttgtgctcgc gactaaaagt caggtagcag caggcattaa cccagtgata gaacatcaaa 300
gtcaaataag tatggtttag cattactgcg tatcttgcga ttgcgtgctg gtggtcaaca 360
gtgcaaacct agtggcttcg cactcaaatg tagacaagca ttaaccaact acttctaacg 420
tatgttcagg aagaatggct attctcgtca ggtgaatgcg taatcgaatg agtagtatgg 480
tcgaacgtcc cgctatagtc tgacacgatt caggcaaagt tggagtgcaa agccatgatt 540
tggtcgatgc ggcaaatgtt gcttaggact attctatggt cttgcgtaat tgtgaagatt 600
tgccagttat ctaaggagac gtggtgattc gctctatagc tgtatctaat ctgccagatt 660
g 661
<210> 294
<211> 627
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 294
gttaccatgt aagaagcggt agacgccatg gcctagtagg aagaatgctt gttcacggag 60
ccgacgaagt tagacgagtg gcagaagaaa gagcattatc ttggtactcg gactgaatgc 120
gtactacggt cgtccaagtt gcaagaggta ttagagtcat tcgaatagct gtgggagtgg 180
tatttatagc ataataagtg taaaaaacat tcccaacagc atatgtgtag ccaagaagcg 240
ttgtgctcgc gactaaaagt caggtagcag caggcattaa cccagtgata gaacatcaaa 300
gtcaaataag tatggtttag cattactgcg tatcttgcga ttgcgtgctg gtggtcaaca 360
gtgcaaacct agtggcttcg cactcaaatg tagacaagca ttaaccaact acttctaacg 420
tatgttcagg aagaatggct attctcgtca ggtgaatgcg taatcgaatg agtagtatgg 480
tcgaacgtcc cgctatagtc tgacacgatt caggcaaagt tggagtgcaa agccatgatt 540
tggtcgatgc ggcaaatgtt gcttaggact attctatggt cttgcgtaat tgtgaagatt 600
tgccagttat ctaaggagac gtggtga 627
<210> 295
<211> 112
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 295
gattacggca cttgtagagc acgtatcaga cccagctttg aaagaaggct gagttcggtt 60
cgggtttcac gtaggcctag aacgaggtat agaagtggtt aacaaagatt tg 112
<210> 296
<211> 91
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 296
gatcactgca aaaaggacta ctcaataatg gtttctaaag tcattatgct ggtgctccct 60
atggcggtgg tcagtactgt aactaaagat g 91
<210> 297
<211> 128
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 297
gattccacat ccgttcttgc aattaaagaa acgatgtaga aaacgctttg gttggcgaca 60
acttgggcgg caaaataatt atggtaggta attgaagtag cgttaaaacg caaaaagaag 120
gaagcacg 128
<210> 298
<211> 129
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 298
gaaagaatag ctgaactcaa agaagccgac aaagataaac aaagaagaaa cggttaatac 60
gattgaggag aaatattcaa tccaacggca actattaacg tttcaactag aatctacgtt 120
tcatacgcg 129
<210> 299
<211> 222
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 299
agcgctagtc catgaaaatg tcctagcttt gaacgtttat caaatgcaag ttgtgggagt 60
tagtcatgtg agagttgtgc aagaaagtgt taacgttcta gccgtgctca gtaacaatta 120
ccattcggcg gtaacaaacg taagttgtca ctgcactcat gagcatgaag ttagaccagt 180
agttgggtca gaaattagac gtggtttagt ctggttaccg tg 222
<210> 300
<211> 269
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 300
gaattcaatg cagaaactcc tatgcacgtc gaactagtct cttgctcagc gctagtccat 60
gaaaatgtcc tagctttgaa cgtttatcaa atgcaagttg tgggagttag tcatgtgaga 120
gttgtgcaag aaagtgttaa cgttctagcc gtgctcagta acaattacca ttcggcggta 180
acaaacgtaa gttgtcactg cactcatgag catgaagtta gaccagtagt tgggtcagaa 240
attagacgtg gtttagtctg gttaccgtg 269
<210> 301
<211> 182
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 301
gatggttagc gtaaacatgg tggaacgtac tttgactgcg ctgcaagaaa tggttgggtc 60
gatcgtaatg ctagtcgtta catcggaaca agccaaaaca aatcattcgc tggatttaga 120
cctactgcac gacgacgtcg acacaagaca ttcttgaaag gtaattgacg tggacgtttc 180
ag 182
<210> 302
<211> 166
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 302
gatggttagc gtaaacatgg tggaacgtac tttgactgcg ctgcaagaaa tggttgggtc 60
gatcgtaatg ctagtcgtta catcggaaca agccaaaaca aatcattcgc tggatttaga 120
cctactgcac gacgacgtcg acacaagaca ttcttgaaag gtaatt 166
<210> 303
<211> 160
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 303
gatggttagc gtaaacatgg tggaacgtac tttgactgcg ctgcaagaaa tggttgggtc 60
gatcgtaatg ctagtcgtta catcggaaca agccaaaaca aatcattcgc tggatttaga 120
cctactgcac gacgacgtcg acacaagaca ttcttgaaag 160
<210> 304
<211> 128
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 304
cttccccatt tgaagtcatg tagtggttgt ctactttttc attgaagacg tccacctcaa 60
cgctatgaac gttagttgag acaatgttaa agcaaacgac aacgtcattg tgatctacat 120
acacagtg 128
<210> 305
<211> 144
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 305
gctacgtggt ggatgaacat ggatgcgaac gacatttcga aatatacgca atgatatcca 60
accctaccga aacagcaata attgtagaag gtagcatatc atgccgagtc atcgacatgc 120
ctttatcgac acacgacgtg attg 144
<210> 306
<211> 120
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 306
gtgtatttat ccgctacgtg gtggatgaac atggatgcga acgacatttc gaaatatacg 60
caatgatatc caaccctacc gaaacagcaa taattgtaga aggtagcata tcatgccgag 120
<210> 307
<211> 124
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 307
gttggtgtat ttatccgcta cgtggtggat gaacatggat gcgaacgaca tttcgaaata 60
tacgcaatga tatccaaccc taccgaaaca gcaataattg tagaaggtag catatcatgc 120
cgag 124
<210> 308
<211> 424
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 308
ctgtcaagac ccttctataa tagtcgaacc agtacggtaa gtgggcaaca tgcccatata 60
agtcgaagca tttcaaatgg ttcatccagt agacgacgat gtcctagaca gtcatgtctg 120
tcacatctat cacgcctcct acgttgtgcc ataacgaaga ataatagtga taagagacat 180
cgaagctgtc gtagtcgttc gctaaattgc ttacaattta gtgctctaag tgaacaatgt 240
ttcatcttga gaagcaaacg aagtagaagt tgacgacgca ttcgaagacg tggacaatgt 300
gacacgagta tcgaaacatg atccaacgaa catcgaagaa gttactactg aactacgggt 360
cagcttcccc atttgaagtc atgtagtggt tgtctacttt ttcattgaag acgtccacct 420
caac 424
<210> 309
<211> 513
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 309
gagtggatgg aagtgtgttc gactgtcaag acccttctat aatagtcgaa ccagtacggt 60
aagtgggcaa catgcccata taagtcgaag catttcaaat ggttcatcca gtagacgacg 120
atgtcctaga cagtcatgtc tgtcacatct atcacgcctc ctacgttgtg ccataacgaa 180
gaataatagt gataagagac atcgaagctg tcgtagtcgt tcgctaaatt gcttacaatt 240
tagtgctcta agtgaacaat gtttcatctt gagaagcaaa cgaagtagaa gttgacgacg 300
cattcgaaga cgtggacaat gtgacacgag tatcgaaaca tgatccaacg aacatcgaag 360
aagttactac tgaactacgg gtcagcttcc ccatttgaag tcatgtagtg gttgtctact 420
ttttcattga agacgtccac ctcaacgcta tgaacgttag ttgagacaat gttaaagcaa 480
acgacaacgt cattgtgatc tacatacaca gtg 513
<210> 310
<211> 141
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 310
gagtggatgg aagtgtgttc gactgtcaag acccttctat aatagtcgaa ccagtacggt 60
aagtgggcaa catgcccata taagtcgaag catttcaaat ggttcatcca gtagacgacg 120
atgtcctaga cagtcatgtc t 141
<210> 311
<211> 45
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 311
gtaaaacttg tcacccccat ttacattgcg acagacacag ttatg 45
<210> 312
<211> 113
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 312
gagtttacta cgttgtagcg agtttagttg aaatagtttg tgatgtgtaa actaaaacat 60
accaaatggt aaaacttgtc acccccattt acattgcgac agacacagtt atg 113
<210> 313
<211> 175
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 313
caccgaattt catcaacaac attaataatt ccataggaac tacattctta aatccttgga 60
actccaaact cctaccttat cacggttcta tccgtcgtct tagggtcggt ctcctcgtag 120
catggcctcg ttctcctcgc cgtaattgcg gtcgaaagta cttcagttat ttatg 175
<210> 314
<211> 290
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 314
agactacaaa atctcaatcc tccattcccc cgtcaggtct atctaaaatt caatcgctgt 60
gtttgcgggg taaataatag gacaagtccg tataatctac ccaatcgcat tcattccagt 120
cagagggtac caccgaattt catcaacaac attaataatt ccataggaac tacattctta 180
aatccttgga actccaaact cctaccttat cacggttcta tccgtcgtct tagggtcggt 240
ctcctcgtag catggcctcg ttctcctcgc cgtaattgcg gtcgaaagta 290
<210> 315
<211> 360
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 315
gattcgtcga acgtccgggt agtatagtta tctgcatcgt ggtcaccagt atcacagact 60
acaaaatctc aatcctccat tcccccgtca ggtctatcta aaattcaatc gctgtgtttg 120
cggggtaaat aataggacaa gtccgtataa tctacccaat cgcattcatt ccagtcagag 180
ggtaccaccg aatttcatca acaacattaa taattccata ggaactacat tcttaaatcc 240
ttggaactcc aaactcctac cttatcacgg ttctatccgt cgtcttaggg tcggtctcct 300
cgtagcatgg cctcgttctc ctcgccgtaa ttgcggtcga aagtacttca gttatttatg 360
<210> 316
<211> 136
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 316
gttcgactag acctctcgtg gtagggcctg gaagtcaaaa gacttctcta tgggtactag 60
gtaggtagtt agagtacggt ccctggggtg tctcagagtc gaacgttcgg gggaagttcc 120
taaacatgtt aggatg 136
<210> 317
<211> 476
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 317
gatagtgggg gacctgagtc atactagggt aacttcttat atggtgacat cactcctacc 60
gtagaggggg gacggtagtc tgtgggaaat ctaccctagt gaagaaaggt aagagaatgt 120
ctgaacatta cctgtagacg aaggtactct cagaacaact actctcacat acggaaaggt 180
ttgggtcctt ggtcaaagga ctttactgac tctgcagacg atgaatatct gaaccaacac 240
tactatcaaa gatgtcgtag gtttgtgaga agggagaaga agtggttgag aagttggtgt 300
tccacaagtt aaagtagaca tacctttagt acctgtaaag gttcgactag acctctcgtg 360
gtagggcctg gaagtcaaaa gacttctcta tgggtactag gtaggtagtt agagtacggt 420
ccctggggtg tctcagagtc gaacgttcgg gggaagttcc taaacatgtt aggatg 476
<210> 318
<211> 255
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 318
gatagtgggg gacctgagtc atactagggt aacttcttat atggtgacat cactcctacc 60
gtagaggggg gacggtagtc tgtgggaaat ctaccctagt gaagaaaggt aagagaatgt 120
ctgaacatta cctgtagacg aaggtactct cagaacaact actctcacat acggaaaggt 180
ttgggtcctt ggtcaaagga ctttactgac tctgcagacg atgaatatct gaaccaacac 240
tactatcaaa gatgt 255
<210> 319
<211> 256
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 319
gtgtttaggt gtgtcggagg gcagaaacca acgaaagaaa ggaaacgatc aacacttata 60
tagtgtcctg tcgggcccaa atcctaagag accttaggtt taccacatta gtactaaaca 120
gcctgttgta taccgtgagc ccccacttcg atctgtaaat ggtaatccct tgtaaaacct 180
catctccaaa aacagtatac gcaggtacag ctgatgtgat cctctctact agtcttctct 240
gaggaaccat gagatg 256
<210> 320
<211> 262
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 320
gagtaggtgt ttaggtgtgt cggagggcag aaaccaacga aagaaaggaa acgatcaaca 60
cttatatagt gtcctgtcgg gcccaaatcc taagagacct taggtttacc acattagtac 120
taaacagcct gttgtatacc gtgagccccc acttcgatct gtaaatggta atcccttgta 180
aaacctcatc tccaaaaaca gtatacgcag gtacagctga tgtgatcctc tctactagtc 240
ttctctgagg aaccatgaga tg 262
<210> 321
<211> 203
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 321
acgtataggt gtgctctcag ctgccgttcc ggcgctgctt cacccctttc cgcttatcgc 60
ggatggtaaa gtcaaagttt actcagcggt cgctgttgac ctcaggttct ctatcaaaaa 120
tttgctggct aaaacggtcg gagcttctgc tccactcttt ccagcaatcc ttctgccagt 180
cgccttcaaa cttgcaatct gtg 203
<210> 322
<211> 240
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 322
gtgaggcatc tataccgcca cgccctatgt ctttctcacg tataggtgtg ctctcagctg 60
ccgttccggc gctgcttcac ccctttccgc ttatcgcgga tggtaaagtc aaagtttact 120
cagcggtcgc tgttgacctc aggttctcta tcaaaaattt gctggctaaa acggtcggag 180
cttctgctcc actctttcca gcaatccttc tgccagtcgc cttcaaactt gcaatctgtg 240
<210> 323
<211> 210
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 323
gtgaggcatc tataccgcca cgccctatgt ctttctcacg tataggtgtg ctctcagctg 60
ccgttccggc gctgcttcac ccctttccgc ttatcgcgga tggtaaagtc aaagtttact 120
cagcggtcgc tgttgacctc aggttctcta tcaaaaattt gctggctaaa acggtcggag 180
cttctgctcc actctttcca gcaatccttc 210
<210> 324
<211> 84
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 324
gtacaagagt tggttactct cagtcccatt cccaacacat cactgagaag tatagagcct 60
agtggtcatt agaaggtcaa catg 84
<210> 325
<211> 67
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 325
aagccttgaa acggtctgtt cctcgtgtca agttctttgt ccgcttatac cgccatctct 60
cgttgtg 67
<210> 326
<211> 116
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 326
gttttacaaa ggagaacttc caacatcagt gtatgggatg tttcaaacac ccccagagac 60
ggagacaata gtgtggtcac gtacatttag gaagataaaa ataacaacaa cagaag 116
<210> 327
<211> 342
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 327
gcttgtccgc gagtgtcaac cgggttttac aaaggagaac ttccaacatc agtgtatggg 60
atgtttcaaa cacccccaga gacggagaca atagtgtggt cacgtacatt taggaagata 120
aaaataacaa caacagaagg tgtgaggcgc aaggtacatg ctcttacccc actctcagca 180
cgtagggagc ggagtgtgga agaccaacaa gcccgtcgcc tctaccaaat acagctatcc 240
tgaggtgcca ggttagaata ggccctacca catctaagcc ttgaaacggt ctgttcctcg 300
tgtcaagttc tttgtccgct tataccgcca tctctcgttg tg 342
<210> 328
<211> 234
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 328
gcttgtccgc gagtgtcaac cgggttttac aaaggagaac ttccaacatc agtgtatggg 60
atgtttcaaa cacccccaga gacggagaca atagtgtggt cacgtacatt taggaagata 120
aaaataacaa caacagaagg tgtgaggcgc aaggtacatg ctcttacccc actctcagca 180
cgtagggagc ggagtgtgga agaccaacaa gcccgtcgcc tctaccaaat acag 234
<210> 329
<211> 484
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 329
ttatgataac aagtccaaac gtggacgtcg tcgctgtcac ctctcggaac actagctgag 60
gtggcttaaa aacattccgt aactgagtgg tcaccggggg tgaaacatgc tgagggttct 120
accttaacgg gaaggtgaaa ctctccaatg tctttgaaag gactagttga gataacccaa 180
accgaatccg gaggaagagg agaacttgga aaacgttgta cgacgtcatt aataacgatt 240
ccgttcttcc cgttcgtgtc tataaggata ttctttcatt gcgaaggtaa gcccttttgg 300
gtctagatac ggactatact caaaaaccca cagaccttcc acttggagtt gttttaggag 360
acggagtagt agagaaaact tgtggcacct tcccagtcgg ttccctacag actctcctta 420
gtagctccta agatcgtcga gttacacgac gacattgttc cgactgacgt agaggcatta 480
cttt 484
<210> 330
<211> 478
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 330
ttatgataac aagtccaaac gtggacgtcg tcgctgtcac ctctcggaac actagctgag 60
gtggcttaaa aacattccgt aactgagtgg tcaccggggg tgaaacatgc tgagggttct 120
accttaacgg gaaggtgaaa ctctccaatg tctttgaaag gactagttga gataacccaa 180
accgaatccg gaggaagagg agaacttgga aaacgttgta cgacgtcatt aataacgatt 240
ccgttcttcc cgttcgtgtc tataaggata ttctttcatt gcgaaggtaa gcccttttgg 300
gtctagatac ggactatact caaaaaccca cagaccttcc acttggagtt gttttaggag 360
acggagtagt agagaaaact tgtggcacct tcccagtcgg ttccctacag actctcctta 420
gtagctccta agatcgtcga gttacacgac gacattgttc cgactgacgt agaggcat 478
<210> 331
<211> 209
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 331
gtgaggcttg tccgcgagtg tcaaccgggt tttacaaagg agaacttcca acatcagtgt 60
atgggatgtt tcaaacaccc ccagagacgg agacaatagt gtggtcacgt acatttagga 120
agataaaaat aacaacaaca gaaggtgtga ggcgcaaggt acatgctctt accccactct 180
cagcacgtag ggagcggagt gtggaagac 209
<210> 332
<211> 146
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 332
gtgaggcttg tccgcgagtg tcaaccgggt tttacaaagg agaacttcca acatcagtgt 60
atgggatgtt tcaaacaccc ccagagacgg agacaatagt gtggtcacgt acatttagga 120
agataaaaat aacaacaaca gaaggt 146
<210> 333
<211> 144
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 333
gtgaggcttg tccgcgagtg tcaaccgggt tttacaaagg agaacttcca acatcagtgt 60
atgggatgtt tcaaacaccc ccagagacgg agacaatagt gtggtcacgt acatttagga 120
agataaaaat aacaacaaca gaag 144
<210> 334
<211> 80
<212> DNA
<213> Artificial Sequence
<220>
<223> exon
<400> 334
gtgaggcttg tccgcgagtg tcaaccgggt tttacaaagg agaacttcca acatcagtgt 60
atgggatgtt tcaaacaccc 80
<210> 335
<211> 25
<212> DNA
<213> Artificial Sequence
<220>
<223> XhoI site - T7 promoter
<400> 335
ctcgagctaa tacgactcac tatag 25
<210> 336
<211> 35
<212> DNA
<213> Artificial Sequence
<220>
<223> polyA-tail - NsiI site
<400> 336
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa tgcat 35
<210> 337
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Primer
<400> 337
gctaatacga ctcactatag 20
<210> 338
<211> 26
<212> DNA
<213> Artificial Sequence
<220>
<223> Primer
<220>
<221> variation
<222> 26
<223> v = any of a,c,g
<400> 338
tttttttttt tttttttttt tttttv 26
<210> 339
<211> 12643
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV1
<400> 339
agagttcctt cctccatacg cagttatgca agtcattgct gtatcccata aacctgtcaa 60
agtcactgta tccggttatg taaggtctag aggaatgcgt agtcatttat ggaaatatct 120
cagctaagtg tagttgcggt aaaatgtgtg tagcggctgc tgttttcccg actttcaccg 180
tgagatgatt aaacaagtac actcttgtta tttgttataa gctcatgtgc agctacccta 240
tcacgagagc ggtccggcgg gtgaagcatt aacaggaaac tcatcacgtc ggcgtaatta 300
aatcgtacac cggtcgtgga atcgcacttc gctagcagtt taacatgcgt gcggtccaac 360
cctacataca cgatacctga aaatcgcgat gggcttagta acgggtagct aaaacggtat 420
tccgaagcgg cgcatcaatt cgctaaggtg tggttgttct cattacacgg cttagataca 480
attatagtgg caaggaacac aattagttat taccaacggc gacgaatagt agtttacttc 540
ctccctgcgg gcccctcctg aagtgccacc tatacggctt gttgaagccg attagtacaa 600
tagatttatt caaccccaaa ggtctacact cccggcttac tcttagctga tatgtcgcgt 660
cgagtcccgg gtttgagtgc gttagcgccg ggttgtctgg cccagttcga cttttgggta 720
cctcatcggg ttacactggc tgacacttat tcttcagata aggttccctt attgggacta 780
gtaactgagg tttgaaacta tccctacttc taatggtctt aactctttcg catgaatgac 840
ggtacgagct taccttacga ggttatcact tatccaagtg cagggtgctc ttccagctct 900
tgaagaggac gtagagagtt ggatgtatta gatgggcgta cgcattatgt gcccacttgt 960
atgattgtgc gttttcaagg aaggaagtat gcatcgattc aaagtaatgc ctctacgtca 1020
gtcggaacaa tgtcgtcgtg taactcgacg atcttaggag ctactaagga gagtctgtag 1080
ggaaccgact gggaaggtgc cacaagtttt ctctactact ccgtctccta aaacaactcc 1140
aagtggaagg tctgtgggtt tttgagtata gtccgtatct agacccaaaa gggcttacct 1200
tcgcaatgaa agaatatcct tatagacacg aacgggaaga acggaatcgt tattaatgac 1260
gtcgtacaac gttttccaag ttctcctctt cctccggatt cggtttgggt tatctcaact 1320
agtcctttca aagacattgg agagtttcac cttcccgtta aggtagaacc ctcagcatgt 1380
ttcacccccg gtgaccactc agttacggaa tgtttttaag ccacctcagc tagtgttccg 1440
agaggtgaca gcgacgacgt ccacgtttgg acttgttatc ataactgatt atgagtaacc 1500
gcaagacagt gtaaacactg taatccatac ttgattgaga tcccttgaaa atgctggtac 1560
cattttctaa actcgatggt ttgttgacaa ttatttgtac agcgacgcat ctagcggttc 1620
ttggtcgacc ctactcacgc aataaatgca gcacgttcga cccagactca tccatggtag 1680
cttcaaatac ggattcaacc tggcgtttat atccagaaaa cggccctagg ggtgatagac 1740
acttaacact ttgggcaacc attggacatg tttcacgtat cgatatagta accattattc 1800
tgcatttgcc tcctagcgag tgaggaagaa gcctttctat tggcttctta atcctcccat 1860
accacgcgcg tacctttccc ggcccttcat tgagaccgga agtgccttgt tattcaatgt 1920
taaacccttg tcagcctatc gcggtgatgc acgaaaaaac caaatggagt atagagcatc 1980
aactactccc aattttaagt gccctcttct aggttgcatt catatatcaa tgtagacttc 2040
gcaagctagt gaatgaggga aatgaattta tccggaatga caaaggggac cgagcattca 2100
agatgcgaac cgttagatgg gcgttccagt ctgcacagta agcctttgtt ttttaaccat 2160
tgaaggaatc gacttcacga cccttgcgag ttcagtcatc agaagaagag accttcagcg 2220
ctccccccct gaaatagtac agcttcaaac aataacctga gtaagttggt atccgaggta 2280
ctatgagttt ctcgaccgtt cgacgccccc atcctatgtt taaagagctg tcatccctag 2340
cctcgagctt acacaggaac cagctgagtc taggctgggc ccacttgggt tgcttgcata 2400
tacaaaatga tgtacaccgc aggacctgtc ccttagggaa ttgtggttga ccaaaagtcc 2460
gctacccatc ggcgtcgtgt cacttttgtg ccgataggta tgatcaatct cttggaggct 2520
attacgatgt tggtaaaaga ttagaactgc tagacagctg ttgataatca agtcgctccg 2580
tagattgccg agaatcagtt gagatgagta cgttatttag ggcgcacgag ctgcgattga 2640
gttggtacca tcgtagttta cgcctatgtt agtccccaat tatacgccct ttgcccgaat 2700
ccccactatc tgtgaaatgt ttaacgcgtt cgctacctct acaaaataca tagctacgtc 2760
atacgtaaga atatcttaac ggaggatcgc acactctctc ctcggacaga taagcgggga 2820
agtaggaggg tatggtgcac gcatggaaag ggccggtaag taattctggc cttcatggaa 2880
cgatatgtta taatttggaa attgtcggat agcgcgacta tgtgcttaat tggtttactt 2940
caaatctcgt agttggtgac agtaaaaatt cgccggagaa gttccagcgt aagtatatgg 3000
ttacaactga acgattccag gatttactcc cttaagctaa ttagacctat ctgtttcccc 3060
tggctcctaa gttttgcggt cggcgattta cccgcaagga gacgcatgtc attcggaaat 3120
aaaaaattgg aaacttcttt ggctgttgtg ctgggaacgc tcatgtcaat acttttcttc 3180
tctagaagtt gaaagggggg gatattatca tgtcgaagtt cgttataaga gtcattctac 3240
catgcacacc atgattctga aagtgctggc aagctgcggg aacgagatac atatttctca 3300
tcactagggc tcagacctca agtgagtcgt tggtcaactc aggtccgagt cggaagaacc 3360
caacgaacat gtaactctca ctacgcgtgt tgtcctggtc agagcactcc ttaacactaa 3420
ctggttttca ggcgatacgt agctgcggca gagtcaagtc atgggtattg atagtagtta 3480
gagaaccacc gataatgtta caaccgtttt ctaattttga cgttgtgtgg gcaactatta 3540
gctgagcgag ctaactaaca gctcttacaa atctctactc atacaataag ttccgtgagc 3600
tcaacactaa ctcaacctgg gtaacatcag atgccgatat attcaggggt tattatgcga 3660
gatatgcgct tagggatagt agacacttca caagttgcgc atgcgatcga gacattttat 3720
gaatcgatgc aatgtgcatt cttatagaat tgcctgttag cgtaacatag gtgaacgtgc 3780
ctaattaccc tctcacccgc gcttattgca tccgtaccat ttccggccat tcattaagat 3840
cggaagtacc ttgcgataca aaattaaact tcaaatgccc tatcacgcgg atttagcagt 3900
tattttaatc aactttagtg gaccaatcat agacattttt aggcggtatt ttcggggtgg 3960
catttaaata ctaatgatga catattaggg tcttaaatga gagaattcga ttaatttggt 4020
tagacaaggg gatccgaaga tattttaccg cagccactaa aagggcgtac ctctgcctac 4080
aataagcctt tattcttaaa tgtctgaaga aaccgcgaag acggctgtcg tcaatacaaa 4140
tatgataaga gcagtactac atctttgctc cgcaataacg gtacagcttc aggtaatatt 4200
cacagtaaaa tggtacgtcc ggtactaaga ctttcatgac tgttcgacgt ttatgcttta 4260
ggtatgaaga gtagtggccc ggtgtctgga gatcatccta catccgattg actccaagca 4320
cagccttctc ggcttgctag tacattgaga gtgatacgct caactggacg agactcgaga 4380
ggaaatacga ctgaccgtaa gaccgctttg ttccgacacc gtcttagcac agcactcatg 4440
attatcatca ctcttttagt gcctattaca atgctggcaa gagaataaat ctccatcaca 4500
ctccttgaaa atgcacttgg tcgtttgatt gttgagaaag tttaatgatg agtatgttat 4560
tcaaggcact ggtgtactga tagagttggg ctagatgtta actacgagtg tataaccctt 4620
caatgactcg ctctatacgc aaattcctat catctgtgaa gtgttcaacg cctatggcaa 4680
ctctgtagaa tattcatctg cgttacacct tagaatatct tagcgggcta tcgcaacaca 4740
tccacttgtg ccgattaatg ggagagtggg cgcgataatc gaaggtatgg tggacgccgg 4800
taggtaattc taggcgacaa ggaatgctat tttcttaatt attctttagg gcattgtacg 4860
cctaaatcat cagcaaaatt tgttgaaatc acctcgcttg attttgtaaa gatctgtctt 4920
aaaaccgtca ccgttaatta gagattacta cactataatc ccagaattta cattcttaag 4980
ctatttaaac taacctgttc ccctaggctt ctataaaacc gcgtcagtga ttatccccct 5040
cggagacgga tgtttttcgc gaataacaat tgacagattc ctatgtcgct tccgccgtca 5100
gcaattttgt tttcactata ctcgttgtga cgtagattcg tcgcgttatt gcgttgtcga 5160
actccataaa aagcgtctct ttgccgtgca ggtcaagatt gtgaaagtat agacgagcag 5220
caaatacgaa aaccgcactt ttgaccacgc ggccacagac ctctggtagg aagaacgctt 5280
actgaggttc gtgtcggtag tgccaaacat ccatgtgacc ctgacagtgc gaattgacct 5340
gccttgagct cttccatatg ctgactagca ttctggcgaa acaaggctgt ggtagtattg 5400
tgccgtgagt actaatagta gtgaaaaaat cagggataat gtctcgacgg ctcacttact 5460
tagaggtagc gtgagacacc tttacgtgaa ctagcaaaac gacatctctt ttaaattatt 5520
tgtcttacag ttacttccgt gatgacatga ttatcccggc ccgatgtaca attgatgttc 5580
tcatattgga aaactactgg gccagatatg tattaaagca tagcacgtac atcgcaagtt 5640
ccggatatcg ttaagactac ttataagtaa tcccattgcg gaatcttata atatgacccg 5700
atagcgttgt gttggtggag acggcagatt acgctctcac cggcgctatt agcttccata 5760
ccagctggca acatccatta agatccgcta ctcctcagga aaaaagtatt tataagaagt 5820
cctgtaacat gtgcatttga tagtcctaat tgacaacatt actcgggcga actaaaaccc 5880
ttgagcacag aattttagca gaggctaata atgtgatatg atatgaaatt agggtctata 5940
tagttataat ttggtgagtt aaattggatt aggagtttgg aagatgattt ggcacagtta 6000
gtcacagacg aaggacttgc cttcaaaaag cggttactgt tgtctgtctt gggtttcagc 6060
gaaagcagga gtcgttgaag caaaagtaat atgtccgaca ttgcatctag gcaaggcaac 6120
ttcgcaacag gtcaacctgt tctttgtaga gaaactagag gtccagttca aacactctca 6180
tttgtgcagc tcgtttatgc atacggcgtg taaactggtg cgtcggtgta tggagacctt 6240
ccttcttgcg tatgattgca tggactgcga tcacgttttg tgggttcact gggactgtca 6300
cgcttaatcg ctcggaattc gagaaagcaa acgacaccat cctaacatgt ttaggaactt 6360
cccccgaacg ttcgactctg agacacccca gggaccgtac tctaactacc tacctagtac 6420
ccatagagaa gtcttttgac ttccaggccc taccacgaga ggtctagtcg aacctttaca 6480
ggtactaaag gtatgtctac tttaacttgt ggaacaccaa cttctcaacc acttcttctc 6540
ccttctcaca aacctacgac atctttgata gtagtgttgg ttcagatatt catcgtctgc 6600
agagtcagta aagtcctttg accaaggacc caaacctttc cgtatgtgag agtagttgtt 6660
ctgagagtac cttcgtctac aggtaatgtt cagacattct cttacctttc ttcactaggg 6720
tagatttccc acagactacc gtcccccctc tacggtagga gtgatgtcac catataagaa 6780
gttaccctag tatgactcag gtcccccact atcctagctc tccttaatgc tgactggcat 6840
tctggcgaaa catagctgcg gcagaatcga gtcgtgagta ctaatagtag taagaaaatc 6900
acggataatg ttacgaccgt tctcttattt tgaggtagtg tgaggaactt ttacctgaac 6960
cagcaaacta acaactcttt caaatcacta ctcatacaat aagttccgtg agcacatgac 7020
tatctcaacc cggataacaa ttgatgctca catattggga agttactgag cgagatatgc 7080
gtttaaggat agtagacact tcacaagttg cggataccgt tgagacatct tataaataga 7140
cgcaatgtgg aatcttatag aatcgcccgt tagcgttgtg taggtgaaca cggctaatta 7200
ccctctcacc cgcgctatta gcttccatac cacttgcggc catccattaa gatccgctgt 7260
tccttacgat aaaaaaatta ataagaaatc ccctaacatg cggatttagt agtcgtttta 7320
aacaacttta gtggagcaaa ctaaaacatt tctagacaga attttggcag tggcaattaa 7380
tcactaatga tgtgatatta gggtcttaaa tgtaagaatt cgataaattt gattagacaa 7440
ggggatccga agatattttg gcgcagtcac taataggggg tgcctctgcc tacaaaaagc 7500
gcttattgtt aagtgtctaa ggatacagcg aaggcggcag tcgttaaaac accatctcat 7560
ggttcctcag agaagactag tagagaggat cacatcagct gtacctgcgt atactgtttt 7620
tggagatgag gttttacaag ggattaccat ttacagatcg aagtgggggc tcacggtata 7680
caacaggctg tttagtacta atgtggtaaa cctaaggtct cttaggattt gggcccgaca 7740
ggacactata taagtgttga tcgtttcctt tctttcgttg gtttctgccc tccgacacac 7800
ctaaacacct actcctaaag catgtacatc gcaagttccc gatatcgttt aggctaccat 7860
ttactaaccc cattgcggaa tcttattata tgatcggata gccttgtgtt cgtggagacg 7920
gcacattagg ctcgcaccgg tgctattacc ttccatacca gctggcaaca acgattatca 7980
tccgctactg ggcaggaaaa aagtatttaa aagaagtctt gtaacaaatg tattacatgg 8040
tcctaattgg ctacatcact cgggcgaacc aaaacccttg agcacaaaaa ttaagcagag 8100
gctaatcgcg tgatatgatt taaaatttcg gtctgtatgg ctataatttg gtgagttaaa 8160
ctggattagc agtttgctag acgatttggc acagttagtc acagacgaag gactcactat 8220
gaaaaggcgg tttcagttgc caatcttgga tttcagcgaa agcaggaacc gatgtggcta 8280
aagaaatacg tccgtcattg catctaggta aggcatcttg ccgaaaagtg aacctgtact 8340
ttgtaaagga actagaggtc ctctttatgc tctgtggttt gtgcagctct tttatgcata 8400
cgacgagtaa acaggtgcgt gggtgtatgg ggaccttcct ttttatgtat gatcggatgg 8460
actgcgatca cattttatgg gttccctggg actgtcacgc taaatcgctc ggaaattgag 8520
aaagcaatcg actacttgca atgacgcact gaccgaactc gagcataacg ggtcacacac 8580
cataatcttc gcctctttag tcccagtcat tcagcaccgc ggtagacgtg taacaaccgg 8640
ccactgccca tctacatatg atcgtattgc tttagaatta acttaataaa taggatgcgc 8700
ggggaggatc tactgtactt atgcgaccac gctacgtact aacttgaagg ctacgtccta 8760
ttcttggcct tgtgcataca taacatgaat acgtacatgt aggattcaga agttgtagca 8820
aatcccacgc tgaacgtttg gggaaaggcc tcagcattat atcctagcct gtcggaacac 8880
aagcaccttt cccatgtaaa cccagcgtca tcaccacaat gaatagtccg accgatcgtt 8940
attgctatta gtacatgatg actcgtcctt ctaacacaaa ttttctactg aatattgatt 9000
acaaaatgta ccaggattag ccaacgtggc gagcccccct ggttttgggt actggtgatt 9060
ttatttcgac tcagatcagc gcactaaact gaattctaaa gctagacatg cagatattaa 9120
agctctctat ttgacctagt cgataaacaa tcagctagac cgtgtcttac tgtgtctgct 9180
tcttgagtga taccttaccg ccgaagtcga cggttactac ctagggtcgc cttgatcctt 9240
cgctacaccg gactccttat ggagagagta acgtaaatct attttgtaga gcgacctttc 9300
ccttggtcat gaaacatttc gttgatctct aagagaaata cgagacacca agcaggccaa 9360
gaattttcgt ttgctcctca ttagtccacg cacccgtttt cgcttgggag taaagattca 9420
tgttagtcta cctgatgcta acgtaaaata ccctagggac gccgacagtg ccattatgtg 9480
agcctcttac tgttaggtta ggtgttgatc gatactgggt gactggcttt acctcgtatt 9540
gcccagagtg cggtatttaa aacggtcaaa ttaggcccag aaagttgtaa cgccatccgc 9600
acattgttgg ctggtgaccg gtaggtgtac aataatataa ggtattcaaa attgaattat 9660
atatcctttg cgcccgtcct agatgacacg aacacagtgg aacgatgcat gattctgcat 9720
tcgatccagg ttatgagcgg gaactcgtat ttaaagtttt tgtccctgtg aaacctgagc 9780
cttcaacatc gtttagggtg ggacttgcga accccttgcc aaagtcgtaa tataggatcg 9840
gacaatcctg tcttcgtggt aagggtgcat ttgggacgct gaagtagtgt aacttatgag 9900
ggaggctaat tatagcaaaa actatatacc agtgagctgg aagattgtgt ttaaaagatg 9960
actaataaat attgttgtac atgctcctaa tcggttccgc ggctcgcggg caccagaacc 10020
catgacctct aaaatagagc tgagtttaga cgcgcgattt cacttaagat ttcaacctgt 10080
acgtctattg tatccaggga tatactgcat cccctatcag tctatcgatc tcgcatacaa 10140
tgactcagac gaagaactca ctatggaatc gggggatcgg gcgccaacga tcgttccgat 10200
cagaacaaga aagctatgtg gcctgacgaa tacttctctc attgtgttta gataaaagat 10260
cccgctggaa taggatccag accatgttga ccttctaatg accactaggc tctatacttc 10320
tcagtgatgt gttgggaatg ggactgagag taaccaactc ttgtacctat attaacactc 10380
aagagttgct tcctccatac gcagttatgc aagtgattgc tgtaatccat aaacctgtca 10440
aaaccacaac gagagatggc ggtataagcg gacaaagaac ttgacacgag gaacagaccg 10500
tttcaaggct tagatgtggt agggcctatt ctaacctggc acctcaggat agctgtattt 10560
ggtagaggcg acgggcttgt tggtcttcca cactccgctc cctacgtgct gagagtgggg 10620
taagagcatg taccttgcgc ctcacacctt ctgttgttgt tatttttatc ttcctaaatg 10680
tacgtgacca cactattgtc tccgtctctg ggggtgtttg aaacatccca tacactgatg 10740
ttggaagttc tcctttgtaa aacccggttg acactcgcgg acaagcctca cgtgtcatgt 10800
ccaactaccc tatcacgaga gcggtccggc gggtgaggca ttagcaggaa tgtcatcacg 10860
tcggcgtaat taaatcgtgc agcataaata actgaagtac tttcgaccgc aattacggcg 10920
aggagaacga ggccatgcta cgaggagacc gaccctaaga cgacggatag aaccgtgata 10980
aggtaggagt ttggagttcc aaggatttaa gaatgtagtt cctatggaat tattaatgtt 11040
gttgatgaaa ttcggtggta ccctctgact ggaatgaatg cgattgggta gattatacgg 11100
acttgtccta ttatttaccc cgcaaacaca gcgattgaat tttagataga cctgacgggg 11160
gaatggagga ttgagatttt gtagtctgtg atactggtga ccacgatgca gataactata 11220
ctacccggac gttcgacgaa tcctgaacgc aactagttat tacgaacggc cacgaatagt 11280
agaaaacttc ctccctgcgg gcccctcctg aaatgccacc tatacgggtt gttgaagccg 11340
gttactacga cagatttatt caaccccaaa ggtctacact cccggcttac tcttagccga 11400
tagcacagat tgcaagtttg aaggcgactg gcagaaggat tgctggaaag agtggagcag 11460
aagctccgac cgttttagcc agcaaatttt tgatagagaa cctgaggtca acagcgaccg 11520
ctgagtaaac tttgacttta ccatccgcga taagcggaaa ggggtgaagc agcgccggaa 11580
cggcagctga gagcacacct atacgtgaga aagacatagg gcgtggcggt atagatgcct 11640
cacgcaactt cggctaatca tgttatctaa ataagttggg gtttgcagtt gtgagggcga 11700
gatcagattc gactatacag cgcagtccgg agccctaact cacgtaatcg cgaccctaca 11760
gagcgggtca agctgatgac ccatcgagta gctcaatgtg agcgagtgtg agtaggaagt 11820
ctgtcgcaag gcaataatcc taatcattgg cagcaagctt tgataaggat gaaggttagc 11880
acaattcaga aggcgtactt actgccatac tcgaacggaa tgctttatta aagaaaaggt 11940
tgacgtccca cgggaagatc gagaacttct cctgcatctc acaacctaca taatcttcgg 12000
gcatgggtag tagataggtg aacatacaaa tacggaaaag tttctaccct cacacgtagc 12060
taagcaagtc atagctatac cccacaaacc tttcataatc actgtatcgg gctatctaag 12120
agccaatggc atggctagtc gtctatggca gtttgtcagt taggtcaaga tgcggtaaac 12180
tgtgtattgc ggctcctatt gtcccgactt aaactgcctg atgttataac gaatacacag 12240
tggttaattg tcatttgctt atgcactgct acgccttgtg gaggccggtc cggcgcgcga 12300
agcatataaa tgaagctcgt cacatccaca tagttgtatc gtacgtcggt gtaggaatcg 12360
aacttggcct ctaattccac atgcgtgcgc tgcaagtgta agtgtaccaa atctaaggac 12420
cacgatgggc tttgtttcag gtatccaaaa ggaaattctg atgccgcgct tcgattcact 12480
aaagtgtgga tgttcccttt atacgggttt gatactcttg ttgtagcagg catctttgtt 12540
agctagcact atccccaacg tataacagtc tacttcctcg gtgtgggccc ctcgtcaggt 12600
gcctgccgtg gagcacgttg aagccgattg gtataataga ttt 12643
<210> 340
<211> 6911
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV2
<400> 340
tttatcttgc gtatgggcct acgctactta cacgatacct ggtattcgta atggtcttac 60
caagcgtctg ctgaaacggt attccgaggc gctgcgttaa atcgctatgg tgtggttgtt 120
ctcattagtc ggcaaagaga caattatagc ggctaggaac gcaactagtt ataacgaacg 180
gcctcgaata gtagaaaata tccctcctcc gggcacctcc tgaaatgcca catattcggg 240
ttattgaagg cggttaccac ggcagtttta tccagcctca taggtcttta ttccggggtt 300
actcttaccg gctgtgacgc gtcgtgtccc ggctttgagt gcgataccac cggattgtct 360
ggcttggttc accttttgga ttcctcatcg ggttatacta actgacactt attctttaag 420
taaggacccc ttattggcag tggtgagtga gatttggcac tatccttatt actgatgatc 480
ttacccctgt cgcatgaatt acagtacgag cttactttac caggatacca cttgatcttg 540
tggaggatac tcttccaatt cttgaactgg acccacagag atgagtgtac tagatgggcg 600
tacgcattat gtgcccagtt gtataattgt gtgttttcaa ggaaggaggt atgcgtcaat 660
acgttcagta tcgacataag gtatttggat agtttcagtg acatagacca atagattcca 720
gatctcctta cgcatcagta aataccttta tagagtcgat tcacatcaac gccattttac 780
acacatcgcc gacgacaaaa gggctgaaag tggcactcta ctaatttgtt catgtgtgaa 840
caataaacaa tattcgagta cacgttgatg ggatagtgct ctcgccaggc cgtccacttc 900
gtaattatcc tttgagtagt gcaggcgcat taatttagca tgtggccagc atcttagcgt 960
gaagcgatgg tcaaattgta cgcatgccac gttgggatgt caatctggca gattagatac 1020
agctatagag cgaatcacca cgtctcctta gataactggc aaatcttcac aattacgcaa 1080
gaccatagaa tagtcctaag caacatttgc cgcatcgacc aaatcatggc tttgcactcc 1140
aactttgcct gaatcgtgtc agactatagc gggacgttcg accatactac tcattcgatt 1200
acgcattcac ctgacgagaa tagccattct tcctgaacat acgttagaag tagttggtta 1260
atgcttgtct acatttgagt gcgaagccac taggtttgca ctgttgacca ccagcacgca 1320
atcgcaagat acgcagtaat gctaaaccat acttatttga ctttgatgtt ctatcactgg 1380
gttaatgcct gctgctacct gacttttagt cgcgagcaca acgcttcttg gctacacata 1440
tgctgttggg aatgtttttt acacttatta tgctataaat accactccca cagctattcg 1500
aatgactcta atacctcttg caacttggac gaccgtagta cgcattcagt ccgagtacca 1560
agataatgct ctttcttctg ccactcgtct aacttcgtcg gctccgtgaa caagcattct 1620
tcctactagg ccatggcgtc taccgcttct tacatggtaa cctggaggat atggtgcgca 1680
catggaaagg gccgggaagt aactctggcc ttcacagaac aataagttac aatttgggaa 1740
ccaaatcttt gttaaccact tctatacctc gttctaggcc tacgtgaaac ccgaaccgaa 1800
ctcagccttc tttcaaagct gggtctgata cgtgctctac aagtgccgta atcctgaagt 1860
gctgggaacg ctcaaatcag tagtcttctt ctctggaagt cgcgaggggg ggattttatc 1920
atgtcgaagt ttgttattgg actcattcaa ccataggctc catgatactg aaccatcttt 1980
agttacagta ctgaccaccg ccatagggag caccagcata atgactttag aaaccattat 2040
tgagtagtcc tttttgcagt gatcctcatc aaatgcggat acaatcaggg gttaatatgc 2100
gggaaatggg cttagggatg atagacactt tacaaattgc gcaagcgatc gagatgtttt 2160
atgtatcgat atagtatgca ttcttataga attgcctcct agcgtgacag agacaagcct 2220
atctattcgc tccttcatcc tcccatacca cgtgcgtacc tttcccggcc attcattaag 2280
accggaagta ccttgctata caatattaaa cctttaacag cctatcgcgc tgatacacga 2340
attaaccaaa tgaagtttag aggatcaacc actgtcattt ttaagcggct tcttcaaggt 2400
cgcattcata taccaatgat gacttactaa ggttctaaat gagagaattc aattaatctg 2460
gatagacaaa ggggtccgaa gattcataac gccagccact aaatgggcgt tcctctgtgt 2520
acagtaagcc tttatttttt aacctttgaa gaaaccgaca acacgaccct tgcgagtaca 2580
gttatgaaaa gaagagatct tcatctttgc ccccctataa tagtacagct tcaagcaata 2640
ttctcagtaa gatggtacgt gtggtactaa gaaccgtgct tccttctttt tgcgttttaa 2700
cgctacttca attacctacc ataattattt tgccgcccaa gttgtcgcca accaaagcgt 2760
tttctacatc gtttctttaa ttgcaagaac ggatgtggaa tccttcgcaa cacaaccact 2820
tctgccgtgt aatccgagag tggccacgat aatcgaaggt atggtcgacc gttgtaggta 2880
ccgcgtatga aacgtagatt ctagttgaaa cgttaatagt tgccgttgga ttgaatattt 2940
ctcctcaatc gtattaaccg tttcttcttt gtttatcttt gtcggcttct ttgagttcag 3000
ctattctttc cttggaagtt tttcgccaaa aacaacagac agaacctaaa gtcgctttcg 3060
tcctcagcaa cttcgttttc tttatacagg ttgtaacgta gataccacgg taaccagact 3120
aaaccacgtc taatttctga cccaactact ggtctaactt catgctcatg agtgcagtga 3180
caacttacgt ttgttaccgc cgaatggtaa ttgttactga gcacggctag aacgttaaca 3240
ctttcttgca caactctcac atgactaact cccacaactt gcatttgata aacgttcaaa 3300
gctaggacat tttcatggac tagcgctgag caagagacta gttcgacgtg cataggagtt 3360
tctgcattga attcctaatt aacgagcctt aaactctttc atttgctgat gagcattatt 3420
gcgagactag cttgagctcg tattgcccgg tgtgtactat tagaagtgaa aaaatcaggg 3480
ttaatgtctc gtcgcctcat ttacatacag atggccggtg acacctagac gtatactagc 3540
aaaacgacat cttaattgaa ttatttatct tacacattct tcctagatga catgaatatg 3600
ctggtccgat gtataattga tgttccgata taggataaca aacctgaaac gtccacgtca 3660
attacctttc aagaatgtct tgtgtcgacg tcgtcgtgca gtaggtctaa atccagcgaa 3720
tgatttgttt tggcttgttc cgatgtaacg actagcatta cgatcgaccc aaccatttct 3780
tgcagcgcag tcaaagtacg ttccaccatg tttacgctaa ccatcctgta ctttgtaaag 3840
gaactagagg tcctctttat actctgtggt ttgtgcagct cttaaatgca aacgacgagt 3900
aaacaggtgc gtgggtgtat ggggaccttc atttttatgt atgatcggat ggactacgat 3960
cacaaccact gtgtatgtag atcacaatga cgttgtcgtt tgctttaaca ttgtctcaac 4020
taacgttcat agcgttgagg tggacgtctt caatgaaaaa gtagacaacc actacatgac 4080
ttcaaatggg gaagctgacc cgtagttcag tagtaacttc ttcgatgttc gttggatcat 4140
gtttcgatac tcgtgtcaca ttgtccacgt cttcgaatgc gtcgtcaact tctacttcgt 4200
ttgcttctca agatgaaaca ttgttcactt agagcactaa attgtaagca atttagcgaa 4260
cgactacgac agcttcgatg tctcttatca ctattattct tcgttatggc acaacgtagg 4320
aggcgtgata gatgtgacag acatgactgt ctaggacatc gtcgtctact ggatgaacca 4380
tttgaaatgc ttcgacttat atgggcatgt tgcccactta ccgtactggt tcgactatta 4440
tagaagggtc ttgacagtcg aacacacttc catccactcc taattcttga ccttgtgcat 4500
atataacatg aatacgaaca tgttggattc agaagttata gcaaatccca ccctaaacgt 4560
ttggggaaag gctttagcat tatatcctag cctgttggaa cacaagcacc tttcccatgt 4620
aaacccagcg tcttcaccac aatgaatact cccaccgatc gttattgctt ttagtacatg 4680
atgacaccat aactgtgtct gtcgcaatgt aaatgggggt gacaagtttt accatttggt 4740
atgttttagt ttacacatca caaactattt caactaaact cgctacaacg tagtaaactc 4800
ctagtccacg cacccgtttt cgcttcgatg taaagattca tgttagtcta tctgatgcta 4860
atctaatata ccctaggcac gccgacagag ccattatgtg agcctcttac tgttaggtta 4920
ggtgttgttc gatactgggt gactggcatt acctcgtatt gcccagagtg cggtatttaa 4980
aacggtcaaa ttaggccctg aaagttgtaa cgccatctgc acattgttgg ctggtgaccg 5040
gtaggtgtac aataatataa ggtattcaaa attgaattaa atatgctttg cgcccgtcct 5100
acatgagaca aacacagtgg aacgatgcat gattctgcat tcgatccagg ttatgagcgg 5160
gaactcgtat ttaaagtttt tgtcgctcaa aaacctgagc cttcaacaac gttttgggtg 5220
ggacttgcga accccttgcc aaagtcgtaa tataggattg gacaaacctg tcttcgtggt 5280
aagggtgcaa ttgggacgct gaagtagtgt aacttatgag gaaggctaat tataacaaaa 5340
actaaattcc agtgaggtgg aagattgtgt tttaaagatg actaataaat attgttgtac 5400
atgctcctaa tcggttctac ggctcgcggg caccaaaacc catgacctct aaaatagagc 5460
tgagtttaga cgcgtgattt cacttaagat ttcaatctgt tcgtctattg tatccagaga 5520
tatactgcat cccctattag tctatcgatc tcgcatacaa tgactcagac aaagaactca 5580
ctatggaatc cgaggatcgg gcgccaacga tcgttccgat cagaacatga aagctatgtg 5640
gcctgacgaa tacttctctc attgtcttta gataaaagat cccgctggaa taggatccag 5700
tactttgtaa agcaggttga gaatcttgta atgttttgaa gatcatcgga ccaatcacgt 5760
cgtgtgtcga taaaggcatg tcgatgactc ggcatgatat gctaccttct acaattattg 5820
ctgtttcggt agggttggat atcattgcgt atatttcgaa atgtcgttcg catccatgtt 5880
catccaccac gtagcggata aatacaccaa ctacctggtt gtaaattttg cagcgttaag 5940
aacatcaatg gatcataaaa ataaaacgtg catcctctag taacaaaatc taagatctag 6000
acaaacttcc aactagtctg aacttagatt aaagaggttt agtaggtaca cggactctgt 6060
cgtatatatt actttaagtg aaatgttttc cagtgttgat caatccctga atagcaaacg 6120
attataatga gactagagtg taaacgttag cgacgaccga gaggttctta gcggcatcat 6180
agttacctct cggctctagt atctcacaaa tggtcgccga tctgatagat tgctcgataa 6240
tctccgtgtg ctttcgtctg tatggcggac tttataaatc tagtatcagt ctggtttaaa 6300
cgatgctgag cataagtgtg cttgaaaacc gccacataaa gggtaaattc gaaaacaacg 6360
agtgtcctgt gaaccatatg cataactaga gtaccccgca cgctagcatg acacatgcct 6420
ccgcaaggct attcttcgat acagtataaa tagattcatt cgcctatttt tctgtttata 6480
tgcgttatat ttacgttgtc tttaattacc tgccagagtt aaagacattc cattgcgtgg 6540
gaccgggttt tcagtaattc gctatattag cttgaagacc agttgggcaa gacccgacaa 6600
gttggttgtg aatgcccccg aataattctc ctaaaactat gcctgggtgt tggcagcagt 6660
ccattgaaac ttcaggcaga aaggcctagc cggcttaagc gagtggaaaa acttagaagc 6720
gtcctgtatt gattatcgag gaaatacttt ctcatttgtg acggatttcc acctcccggt 6780
tctcaggaag gttaaaggtg taattactat tgacgtgact gcagaggaga agagatcttg 6840
ttttcatttt ttggcggtaa cgtgatcctg aatggcgctt atgacggagc aatgtattta 6900
acgtcggagt c 6911
<210> 341
<211> 10943
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV3
<400> 341
aatatttcag gcggtatgtt tactttcatg tacctttaat agctcgttag atagtttagc 60
tgctggtaaa cactctatga tctcggctct ccattgatac tacgacgatt attagagagc 120
cagcaacaat tgcaaatgtc agatcaaagt aatattagca aacaataagt ccctaactag 180
ttgtgacctt ttgtaaagtg aatttcatta tatatgctgt ctctagcaca tggataattt 240
ggagaaatta gattcaagtc tgatcaacct ttaaacagat ctagaatcta aaacaatgat 300
ttcctacgtg caaaataaaa atactaggta actacaagaa ttgtgacgtt ttaaatgttg 360
gtccattaga aacaccattt aggattacgt taccctaaaa aaaagatatc aggaactctt 420
ctcttttgca gtcaggtcta tagaaactac atcattaacc ttcctaagaa ccgggaggtg 480
ggaatctatc atatatgaga agatatttgc tcgataatta atactctagg tttctaactt 540
tttccattca cttaaaccga cttaactttt ctgcctgaag attcattgga ttgatatcaa 600
cgcgcaggca tagttccaga aaaattatcc agaagcaatg acaaccaaca tttcgggtct 660
tgcctaatcg gtctacatgt tgatataata aatcactaaa aactcagtgt tacacaatgg 720
aatgtcctta attctagcag gtaattaaag ggaacgtata tataacgtaa aaaaattgga 780
aaattaacga gagaatcttc tttctgtcta ttgaagaatg gctatataga agcatgcgtc 840
atgctagcgt acagggtact cttactatcc atttgggtca caaaacactc gctgttttcg 900
aatttaccct ttatgcgcca gtattgaacc acgcttatgt ctaacatcgt tacaaccaga 960
ctgatactaa atatataatg tccgccatac aaataaaatt atgacgagaa gcatttcaag 1020
aaagcgttgt agcttaaaaa gaacgttgcg gtgctaaagg agaaagtcga aaaagcgaag 1080
gagttaaaac aaaagccggt tattaaatgc tggaagaagg aagaacaaca actaaacaag 1140
gttgtcaaga gcattaagga agccgtacta tgttacattt cttcaacctt ctaattgcac 1200
ccttaggacg aagacagata tgttcttacc tatatttcat cattggcaac gggatcgcat 1260
gtcccacgta aaacattgtt aaaccctcag gtttttgagc gacaaaaact ttaaaaagaa 1320
attcgcgctc ataacttggt tcgaatacag attctagcat cgttcgtctg agtttgtttt 1380
atataaaacg ggcgcaatgt ttattttaat caattttcaa taccttatat aattgtacac 1440
ctaccggtga ccactcaata atgtggggtt cccgttacaa ctatgaggat ttattaagac 1500
cgatttatat tcggcattgt gggcaaaatg acgtttcaac aatgcccaag ttgacattat 1560
tccaaaacgt ttcgtagaaa tgaaagcgct tcgagtaatt aggcgcaaac ttacaggacg 1620
ccatggcata tgggtggtag aaccaacgat ggaagcgagt agcgcaatgc cttagcgcac 1680
gcctacacta actgcttacg aagttggagc aaaagaaact gaacgtgtca gccaaaattg 1740
ccaagaaaca ggagctacca aaagctagtc cggtgtatcg aaagtacaag actagccttg 1800
ctagtaaccg tggactagga gcctaaggta tcactcaaga tacagactca gtaacatacg 1860
ctttagctat ttaattatcc tctatgtctt atagagacct actggccaaa caacactcgc 1920
aaagaattta tgtgcgcttg gcaggtggag aagcaaatac ttggataccg aatttagagg 1980
ccataggtta tggaaaaagt cagtggtatt taggcgtaca atgccttaaa gaataattaa 2040
aaaaaaagca ttccttgttg cctagaatta cttaccgcgg tttaccatac cttcgattat 2100
cgcgcccact ttcccattaa tcagtagaag tggttatatt gcgatagtcc aatatgatat 2160
tctaaggtat tacgttgata aatattttac agagttacca taggcgttga acactacaca 2220
gataatacga atttacgtat agagcgaatt attgaaaagt tatattctcg taattaacat 2280
ttagtccaac tctatcagta cagcagtgcc ttgaataaca tactcatcat taaattttct 2340
ctacaatcaa acgaccaagt acattttcaa gaagtgtgat ggagatttat tcttttgcca 2400
acattgtaat aggcactaaa agaatgatga taattatgag tactgtacta agatgatgtc 2460
gaaacaaagc ggtcttatgg tcaatcatat ttcttttcga gtttcgtcca gttgagtgta 2520
tcactttcaa tgtacttgca agccaagatg gctgtgctta gagtcaattg catgtagaat 2580
gatctccaga catcggaaca ctagttttta tacttaaagc ataaacgacg aacagtcatg 2640
aaagtcttag tactagacgt accattttac tgtgaataat acttgaagct gtactattat 2700
tgcgctgcat agatgtagta ctgttcttat catatttgtt ttgacaacag tcgtcttcac 2760
agtttcttca aacatttaaa aataaacgct tattgtagac agaggtacgc cctattagtg 2820
gctgcggtaa aatatcttcg gatccctttg tctaaccaaa ttaattgaat tctttcattt 2880
aaaaccttaa tatgtcatca ttagtaatta aatgccactt tgaaaatacc gcttaaaaat 2940
gtctaagatt gatccactaa agttgtttaa aataattgct aaatctgcgt gatagggaat 3000
ttaaagttta attttctatt gcaaggaact accgatctta atgaatggcc ggaaatggta 3060
tggaagttat aagcgtggat gaaagggtaa ttagatatgt ttatctatgt tacgctaaca 3120
ggcaattcta taagattgca tattacatca attcataaaa tatctcaatg gcatgcgcaa 3180
tttgtaaagt gtctattatc cttaaacgca tatctcgcat aataactcct gaatatatcg 3240
gcatttgatg ttacctaggt tgagttagtg ttgagctcac ggaatttatt gtatgagtag 3300
tgatttgtaa gaattgttag ttagctcgtt caagtaatag ttgtctacac aacgtcaaaa 3360
taagaaaatg gttgtaacat tatccgtgat tttcttacta ctatcaatat tcatgatttg 3420
actctgctgc agctacgtat cgcctgaaaa ccagttagtg ttaaggaata ctctgagtag 3480
gacaactcat gtagtaaaag ttatatgttc gttgggttct ttcgacacgg atctgagttg 3540
accaacgtct catttgaggt ctgtactcta atgatgagaa atatgtatct tattcttgca 3600
gcttgtcagt actttcagaa tcatggtgtg tatggtagaa tgactcttat aacaaacttc 3660
gacatgataa taaccccccg tttctacttc tagagaagaa aagtattgac atgagcgttc 3720
ccagcacaag agctaaagaa gtttccaatt ttttatttct gaatgacatg tgtctccttg 3780
cggataaatt accaaccgta attcatagaa gcctgggaaa acagataggt ctaattaact 3840
taagagagta aatcttggaa tcattcagta ataactataa acttacgtta gaacttcttc 3900
ggtgaatttt tacagttatc aattaagaaa tttgaagtaa atcaattaag gatttagtcg 3960
cgctatccga taatttccaa attaaaacat attgttctat gaggtacgaa ttacgaacac 4020
cttaacatta gggaaactta gatagttgta caaagtaacg tataacaagt atcgcgtatg 4080
gtatttgttc tgaatcgacc aaggacacaa tcaaattccg atttgtatct tcaacaaact 4140
tgtacccaac ccccgaagtt tactagcttc tcagatatca tagagcttgt ggttcatcgc 4200
gtccgatatc aaactttgtc atgataaagt tttcccctcg ggaataccag agaaaatgac 4260
tactgaattg tgcaatcctt gcactttaac taaggaagct accaatattt agtttttaag 4320
tcttacgtct gacttcgtag atagattgcc atacatagag cttatgaatc agcgaaaagt 4380
atgaggcgct tttaagtatg gcgagtaagt gatttaacgc ttcggatatg actatatact 4440
taaatttgat ctcgtcccga gaattttaaa cctcaacatt tataaattat aaggttagcc 4500
aaaaaagcac gtggtggcgt ccatcgactg ttcccaaact gtagctcttt gttctgtcaa 4560
gatccaagga ttagatagta aaagtcgaaa tctttatatt cggttcgatg tactacgtta 4620
ttcgcgactg ttctgtcatg atagtttttt atatagtcct aataaaagga gtttttaaag 4680
taaatgacat ttcagtagta aaagtttaag agctttttgt tctgccagac gttctgatag 4740
ttgaggaaaa cgtgtggtca gctaataact tgtggtatgg tgtctgctat cgagtccctc 4800
taatgactgg atagttagac ttgcccttgg aaaacatagc aagaccttgc ctctctattg 4860
atattacggc gaatgttgga gagacagcag cgattgcaaa tatcagatca gagtaatatt 4920
aacataggat aactccgtaa ctgattatga ccttttctaa actttacttg attaaatatg 4980
ctgtctttgg cacatggatg atttagagaa attacattca agactgatta agcatgaaac 5040
aattcttgaa tgtaaaattg ttatctccta tattcaaaat ataaatacta gataactaca 5100
ggaattccga cgttaaatac attactccat tataaacgcc attcaggatc acgttaccgt 5160
cataaaatga aaacatgatt tcttctccac tgcactcacg tcaatagtaa ttactcctat 5220
aacctttcta agaatccgga ggtggaaatc tgtcacaaat gagaatatat ttcctcgata 5280
atcattatag aacgcttcta agtttttcca ctcggttaaa ccggctaggc ttttctgcct 5340
gaagtttcaa tggactgctg tcaacaccca ggcattgttt tagaagaatt attcgagggc 5400
attcacaacc aacttgtcgg gactagccaa actggtcatc aagtttatat agtgaaatac 5460
tgaaaaccca gtcccacact atggaatgtc tttaattctg gcaggtaatt aaagacaacg 5520
taaatataac ggatataaac agaaaaatag gcgaatatat ctatttatat tgtatcgata 5580
aatagctttg tggaggcatg tgtcatgcta gcctacagag tactctaatt atgcatatgg 5640
ttcacaagac actcgttgtt ttcgaattta ccctttatgt gacggttttt aagcacactt 5700
atgctcaaca tcgtttaaac cagactgata ctaaatttat aaagtccgcc atacagacga 5760
aagtacatgg agattatcga gcaatctatc tgatcgacga ccatttgtgt gatactagag 5820
ccgagaggta actatgatgc tgctaataat ctctcggtcg ttgttaacgt ttatagtcta 5880
gtttcattat aatcgtatgt tattcaggga ttgattaata ctggaaaaca tttcagttaa 5940
agtaatatat acgacagaga tcgtgtacct attaaacctc tttaatctaa gttcagacta 6000
attggtaatt tgtctagaac ttagatttta ttactaaagg atgcacgttt tatttaggag 6060
taaacgaaca tccaacagta tgtacaatcg tatgagaaag gacaaatctg aagacgatat 6120
tagagggagt ccaacaagtt tgtgatgatt cacgtaagga aatcgaaatg taagattatt 6180
cgtcaatgga ggtataagac aacacaccaa gtaattatac gcgacgagtt ttcatgttga 6240
cgatccctga gactatatca tacaaaattg acccaaataa taaactcgtt ccaatagttg 6300
aagtgttgat taacacattg agacaagttg tccgtacttt aatcatcaaa gttttggact 6360
gacctataaa tgaaatattc gcgttgtctt cagtttaaga agtgatatta ttttcggttt 6420
caagcctatg tggagagata caggaaatag gtaaactata actaatataa atatacgcag 6480
acgaagcctg ttaactttac caaatccaaa tagcgggaga cactaaactt acaagaaatg 6540
tacggtaaga cagggaaaca gggtttgaag tttggaggta caaaatctta atccttcaca 6600
actgaatcaa catttacatt cggttacgtt cggggtttgt agtagtaatt gttgaggtaa 6660
ttttaattgc acttacagac gtggatttgg tgaaacatta tgtggtagat tcatatttcc 6720
gaatcttaat agacgatttt atgatggtga tcgtggtttc ttttcaaggt ttggtggacg 6780
aaaatgaaaa aatcacaatt taacgtttca tattcatcac aatccgaaat cgagatggag 6840
agaaagtttg actaaacttt gttacagtat ttttgaaggc aatcaacctg gaactttgga 6900
tttcatcaag taaacaccca tatttagcga aaatgcaagc taactgcgaa ctaacaaggt 6960
aactcttttt cgatttcaaa atatggtcag tagcaatatg ttaagtgatc cattttggag 7020
gggtggggat ttgttcaatg aatgaggcaa taaaccaccg caacctctgt aattgacgag 7080
aaacttgtat aaggtcatca aaaagaatag atgaacataa agattgaata cggctgggtg 7140
aggttaattc agatttccca aattatgtag atgaaaagat ggtaagttta ttgataggta 7200
aaaaatcaag agagggtaat aaagaagaaa gaataatcaa aagatagagc atgcaaacat 7260
tacatggtag tattgttata ggcggtatat tggtaaatga cgatccttga cttagttttt 7320
tacatcgaac ggttgcaaat cctagcatac ttgatattaa tagtagatac tgaaatatat 7380
ctgagtatat caagggaaat cgagatgtaa caataagtcg aggaaattaa ggtcaattta 7440
gtgcttatca tagaaataac tacttaagcc cttaacgaac taactcaaat taacgaggta 7500
gaggttattc tgaattgtac gaacgtagtc gaagtttgtt accaagggta aagccaaaac 7560
aaaacgattt gacaagagaa tctattccat gtagtagtgc gtttgtacga cgttctattc 7620
gatgtaaatc attaggacga gggtttgaag caactcggaa agatggtcgg ttagaattta 7680
aaagtactga acggaattaa cgaagttggc tactacctaa tagtctttgc ttaggattta 7740
gtagttcgca attgggtcaa agtggtcgct ttggtcgtcg acgtcaagac tcaacaagtc 7800
atttaccgct gtacgaacca tctcatttaa caggttctca accaaatagc ggtaggagta 7860
gaaagcactt accatcgtac gaactttgac aacgaaaggt tcaaaggtaa ccaaggcgta 7920
gtagtgagtt aggtcaatgt ataaaaactc cctttcttat tttgagtcgt caatgtagtc 7980
gagaaagtgt ccaagcaaaa cgtaacgaaa cggttgagta aggacttgca cactatgccc 8040
ttgcgggttt acctgcttga cgtagtcctg ccacttatta tccgtgattg ttacctaatg 8100
gacaacctaa tcgttagctt aaagaagatg cacttagtgc cattattatt agacaagata 8160
gtccgttctt tagtcgaagt tcttgttgta ataacaaaag tagagcagta ttttgacgta 8220
tagggagaca gtcattaggt cattaaccca gttactaagg acaacgtaac catcgaagtt 8280
attgaacttc aggtacctaa cagtaaaaga gtcacataat gcctctgact gcgtgcctag 8340
ggtatatttg attagtatca aatagactaa aatgaatttt tacatcgaag cgaaaatggg 8400
tgcgtggact aatcaggagc aaacgaaaaa tcttgacctg tttgatgtct cgtaatattc 8460
ttagagatga acgaaatgtt tcatgaccta gaaaaaagtc gttctacaaa atagatttat 8520
gttactctct tcataaagaa ttcggtgtac cgaaagaaca aagcgagttt aggtagtaac 8580
cgttgactat gggggtaaag tatcactcaa gaagcagact cagtaacaca cggtttagct 8640
gattgtttat cgtttaggtc atatagagac ctttaatatc tgtatgtcta gctttaaaat 8700
ttactttagt gcgcaaattt gagtcgaaat aaaatcacca gtacccaaaa ccaaggatta 8760
cgatccgaaa tttcatggac acagatattt gagatcaaca tttgattcgt tgacgtattt 8820
atgttgattc ggttagcgag agttacaaag ttagtaatag aaagaaagag gaaataataa 8880
tcaaaagatt aagcatgcaa acattaagag gacacatatg tattggtggc atttgcgtta 8940
ggttaacgtc tcgtaagacg gtgaagctgc ttaaactatt cggactaaaa tagtgaaatt 9000
tatgatgtgt gacccgttat gctccatttc gatcagtggg ttattactag tagtcgattg 9060
cattgtcatt ttccgagtga tttagcgtga cagtcgcaga gaacccataa aatgtaatcg 9120
tagtccatct aatcatactt aaaaatgaag gtctcctttt acccacgcac ctgtttactc 9180
gtcgtttacg tggttaggtc gcttggtagc atatctgtta ccgaagacac gacagtaaat 9240
tgtcaagcaa acactgcgcc ttcttcggtc gcataaagaa gtgaaccata acgttctcct 9300
acttaactcc gcaacgaaaa agagctattg ctaatccaat ttatctcatg aaattataat 9360
tatatagacc gaaattttaa atcaaatcac ataattaggc tcagctttat tttagtggtc 9420
atgggtttta gtaccattcg ttcaacatga agtggcttat gttcgcggag tagtagcgcg 9480
taaaagtgta ggtacgcgag ctatcgtgcg gtgtagcatc gcagtcaaag cttgcgtagg 9540
tagcgttgca atctcctgta ctaaagacat gcaactgcca gcttgtactg ttggcgaaga 9600
aagttcagtg gatgttacta accgcgttta acgcgtggac acggcggcag ttgagccaat 9660
cgattacgaa acaagctatg ctaatgttga ccatttggct cttcgaccag cagtcagccg 9720
cttctttacc tgccaacgtt gttcataaca ggcaaaacca gaaagtcgca taggttggtc 9780
aactttcgca gaaccaactg ttactgcgat cttcagcttg ccttttgtcc cagattaacg 9840
tgtaattatt aaacaaagtt cggcagttcc agtcgctatc gacaaaaccg aaaccacaag 9900
ttctgtaatt acgcgttcgg caaagcgcaa tgcgccctaa tacttaattt ttttttcgta 9960
aggaacaacg gatcttaatg aatggcgcca aatggtatgg aagctaatag cgcgggtgag 10020
agggtaatta gccatcttca ccaatataac gctatcaggt tatactataa gattccataa 10080
tgcaactatt tataaaatgt cttaatggta tccgcaactt gtgatgtgtc tactatgctt 10140
aaatgcatat ctcgcttaat aacttttcaa tataagagca ttaattgtaa atcaggttga 10200
gataatcatg tcgtcacgga acttattgta agagtaataa tttaaaagag atgttagttt 10260
gctggttcac gtaaaagttc ctcacactac ctctaaataa gtaaacggtt gtaacattat 10320
ccctgatttt cttactacta ttaatactca tgacataatt ctactacagc tttgtttcgc 10380
cagaatacca gttagtataa agaagagctc aaagcaggtc aactcgcatt gtgaaagtta 10440
catgaacgtt cggtactacc gacacgaacc tcagttaacg tacatcttac tagaggtctg 10500
tggccttgtg atcaaaaata tgaatttcgt atttgctgct tgtcagtact ttcagaatca 10560
tgatctgcat ggtaaaaaga cacttattat gaagttcgac atgataataa cgcgacgaat 10620
ctacatcatg acaagaatag tataaacaaa actgttgaca gcagaagtgt caaagaagtt 10680
tgtaaattat tatttgcgaa aaacatctgt ctccatgggg gataatcacc gacgccattt 10740
tatagaagcc tagggaaaca gattggttta attagcttaa gaaagtaaat tctggaatta 10800
tactgtagta atcattaatt tacggtgaaa gttttatggc gaatttttac aaattcaaac 10860
taggtgattt caacaaattt tattaacgat ttagacgcac tatcccttaa attacaaatt 10920
aaaaaataac gttccttgat ggc 10943
<210> 342
<211> 16122
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV4
<400> 342
acttattgtt tgctaatact acattatcct cacaataccg aatgtagttg gctctctaaa 60
aatcctcata gttgcaacgg ggagccgaga ttattgagtg atcaccagta gctgtactat 120
tatataagct attaaagatt gatcaaagta aacataccgc ccgtattata taaatcatac 180
tcagacgaac attgctacaa tccgtattcg caccaagtta tgagcgcgta tttcccatta 240
aagcttttgt cgctcacaaa ccacagggtt taccaatcat tcacgtggga catgcgatcg 300
tactgccaac gatggaatat gggtaagaag ttatctgtct ttcttctaag agagcaatta 360
aaaggttgaa gaaatgcaat atatatgcaa gggaaattaa tggacgatct taattcctgt 420
aaggtagcag attgtgactc aaagatgact aaataatatt gttgtacatc tgcctaatcc 480
gttctgggct ttacgaccaa cagtaaccga gacctataaa aaagagcttg atacggacgc 540
gcaactatac ttaggatacc tagatgtccg tcttttccat tcagccaaat tctgttaccc 600
ttttcaatct acggatctca taattaatag ctcgtttata gaagagtata cactatctaa 660
gggtgggggg ccaacgatcc ttccaatcag aacatcaaag atatctggac tgacgttttc 720
tcctctcaag gactatagaa aaaaaatccc gctgcactag gatctaccgc taagtttacc 780
tggttgtaaa tcttgcagtg ttaagaagat caatggatca taaaaataaa acgtggaccc 840
tttagtaacg aaatctaaga tctagacata tttccaacta gtctgaactt agattaaaca 900
ggtttaatag gtacacgaac tctgtcgtat ataatacttt aagtgaaatg ttttccagtg 960
ttgatcaatc cctgaatagc aaacgattat aatgagactg gtgtagcata gcaactgttc 1020
tgaatgtgat attcggtcag gccacgttga cacttaccaa agcaagacag aaggaagttg 1080
acgggacaat agggaagatt ggcaaaggga tttaaacata gtccagttcg cgtggtgaat 1140
gacagattgc tactgttacc attggcgata ctacgttggc gactttactt gcctcggtag 1200
cgacagaaca agtgtcgtct acgcaacgaa caaccagcgt gttagctgca atgtcccctg 1260
tagaagaccc tcttctttct cttctgaatg atgtagctgt ggatagagcg tctcccacgt 1320
tagggtctag caaccctccg gtggtggttt cgagaacgat ataaaaagtt cccgtacaga 1380
ttgatgggtt agtgttctcc ctgggctgtc gtctgcatga cggaccttat agtagtacag 1440
tcgctttaat ttaaggatcg tggcccagtc agtggattac gttgaccatg agtctggctg 1500
ttcttggttc accattagct gtggtgacaa taacgggcat tgtggcaacg atacgtcgta 1560
ctgcaagtcc cactgtaact aagacaattc ggattcgacc gatacttggt ctggttcgtt 1620
aacttcgcgt accttctgct ttaccagcag gtcgtcaacg acgagccacc gtaacgagtg 1680
tggtttcggt tcgcttggtt gggtgcccaa tttccagtac cgaagaggta attgcaactt 1740
caattgctta gttgacgtga cctttcgggt gtcatggact accgacggta tctcatacgt 1800
gacctcgttg ttgacctcgt tcttcatctg cacagactac aacgttagga ctacggaacc 1860
agtgtgaagt tgacggacgc gctaggttat catcttttat agggaggagg ccggtagagg 1920
actttacggt atataagccc aatgactacc gcgagtggtc ccgtcaaaat aggtcggagt 1980
atccacaaat aaggctccaa taacaatggc tgactcttgg cagcacagcg tcgaaacttg 2040
gggcacagag gcctaacaga ctgaaccaag tggaaaaact aaggagcatc ccaatatgat 2100
tgactgtgaa taagattttc attcgtgggg gatatccgtc accagttact caaaaccgta 2160
ataggaataa tgactactaa aatggggaca gcgtacataa tgtcatgctc gaataatatg 2220
gtggtatggt gatctagaac acctcctata gtttacagat gcggtttatt ggattggtta 2280
caacggcaaa ggcggagacc actccaactg tcggaagagt acctcttcaa attgccattc 2340
caattgctcg tcatggactt tccactctta gacgacccga tgaagctaga agtctgacac 2400
tgaccatgct tgtggcaatc gttgttcatg tagccacttt gactcgacgt tcacgaacat 2460
acgatggtta gttcttctac tatactaatg gcttgttttc gcagaatctg tatttagacg 2520
taacaatgga aataatcttt ttggacattg atctagattc tttaataata ggtttattta 2580
ccaagttgac gtttcacaag ttgttttaaa ccgacttttt ttgatgtgtt tgtagttatt 2640
acagctgaaa gatgacgcgt actagagccg cggcgtgtca aactttgcat gccagtcgcg 2700
acagcgagtc aggttaagac tagcctatgt taatttgcac atgctaacat aagtcaataa 2760
ctttaaccgt cttctttata tgttgttgct gcatgattat ctgtaaccac tatctagtta 2820
ataatatggt tgtaacagtg tctgttacag tcaccatgga ttttgttgtt atggatttgg 2880
ctgttgacac agctgtagcc tatattacgt tttttgtttc cacggttgtt attaatagct 2940
aagacttaga aggagcggcg tttgtgtata cggcggtggt tatggtggtg gttatggcgg 3000
cggtggcggc ggcggagttt gtttgaatag aagctgctat ggaggaggcg gcagcggagg 3060
aggcggtggc agtaatggta attatcttct atatcattat ggtaggtcat ttctagcgct 3120
aatatgttgc agctgagccg ttcaaaattt tctaggtgca tggcttaact accttgttta 3180
tgtctttcct taatttaatt tttttcatag ttttgggcgg ctaccgccaa gctatcattt 3240
atggcaatgg cggcggcggt caggatgacg tttctaaaat gttgctgcgt atcggcaagt 3300
tggctcagga catcaaagca gtcttagcct tttgcccacc tggctgctgc ttgttgtcgt 3360
cgctcggtcg tcgcttaatt ttgttataca tgctagaaac aggttatatt gtaacctgtc 3420
aagtacctat tttttaatag gaaacagatg acttcgtgtt ctgtgtaatt atagttattt 3480
tttagttaat ttagttgccg aaagcttacg tgtttgtgtt gttcaaagac aatttgatgt 3540
ttattaataa cttctattga actatgttgt ttgcatacta ttaggaaacc tgtttaggct 3600
actacagctt gaagttaaca ggctattttt aaatgttctt aagtaatacc gccaccttct 3660
aaactgtaag ttttttgtca tgctatttcg caatcgatta caccacagcc gtaatccttg 3720
gtttggctgg ttagttttta atgttcttaa cgctagctta aatctatttt aatactcaat 3780
gtttaactgc tacagttgac ttagcgttca aatttaccgt gtccaagttg ttgactgggg 3840
gcgagttgtc cgccgtaacg cgttagtcgt ccgataccgc cgtttgaacg tccgggcagt 3900
ttaacaggac gttgtcagaa tgggccaata agtcgtccaa ctttgcgttt gaaagctggg 3960
ccgattggca aggcacaaac tgcactgggg ccgcttgcac ccgtaacagt ttccgaaaaa 4020
ccacttccat tgccgccgat agtttttatt ggtgacatgg cttcgccacc gggaatgact 4080
gaagccgggc cgattggaac aagctatgtc gcgtcgtgtc ccggctttga gtgcgttagc 4140
accggattgt ctggctcagt tcagcttttg gatacctcat cgggttatac taactgacac 4200
ttattcttta aataaggatc ccttattggg agtggtaagt gaggtttggg actatcctta 4260
tttctaatga tcttacccct ttcgcatgaa taacagtacg agcttacttt acgaggatat 4320
cacttgatca agtggaggat actcttccaa ttcttgaaca ggacctagag agttgaatgt 4380
attagatggg cgtacgcatt atgtgcccag ttgtataatt gtgtgttttc aaggaaggaa 4440
gtatgcgtca attcgttcag tatcgacata gggtatttgg aaagttttag tgacataggc 4500
caatagattc tagatctcct tacccatcag taaataccat tatagagtca attcagatct 4560
acgccattta acacacaacg ccgaggataa aagggctgaa attgacagtc tactattttg 4620
ttcatgtgtg aacaattaac aatattcgaa tacacgttga tgcgatagtg ctctggccag 4680
gccgcccact tcgtatattt tctttgagta gtgcaggcgt attaatatag catgtagcca 4740
ggaccttagc atgaagcgat gattaaaatg tacgcacgcc acgttgggat gtatgtgcta 4800
tagactttta gtgttacccg aaacatagtc catcgatttt gccataagac ttcggcacga 4860
agttaagtga tttcacacct acaagagaaa tgtgccgaat ctatgataat atcaccgttc 4920
gttgtattaa tcaataatgg tagcggctgc atattatcaa atgaaggagc gacacccggg 4980
gaggagttca cggtggatat cccgtaccac tatattaatt attccgtaat cctcgtctta 5040
cctttttgct tttatctgga cgtgtttaac attgatgttt gaccagtctt tgcaaaggtt 5100
tatattgtcg tagacgttgt tcagcactat aatcgttagg tcattaacat ctgatgtcta 5160
gtgctaaaga catattatta tgtggttttc tacaacctta tatactaata cagctgtatt 5220
tcttaccatg atgacgtata ccttttacaa ccctttttgc taaattcgga agtttaccat 5280
aaaacatacg actttcatgg aattttccgt tgcaacgatg tagacttcgt cggtgtttat 5340
cattacagta ctgaggatat ggtccaaatc ttttacctat aaaatattta agacgtttat 5400
tacgacttgc attactgtta gtttgtaaac aaggaggatt tcgcataagt cgttgcttta 5460
atttagtttg gttatggtgg gttaatcgac ggatacatct aatataccca atattaataa 5520
aacctcttgt ttttacacgt ggcgttcgtt acggttttaa atactaaccg aaacatttgt 5580
aagcattact gctgttaagt aatgattgac gttttaccct gtaaaattat ttttgagctt 5640
atgtaaacag accatacgtt cgatgttctc ttacccaacg ttcttgcact gcatatggtg 5700
gtgttaccaa gtgtagcgtt atgtgagtta aggcaatggt tttatattta gatgttccta 5760
ataatgcttg cccattatgc cgttttgatg gttgtttctc tggtgtttac gttagattac 5820
atccgtaaga tggttacacc tcactcctac aacggaaata tgaccaaagt atcagaacaa 5880
catggtccgc agaaagaatc gatcgtgata aaggttggat cttgacagaa caaagagcca 5940
cactctggga gcagtcgacg gacgccacca cgtgcatttt cggctaacct tataatctat 6000
aaatgttgag gtttacagtt ctcggggcga gatcaaactt aagtatatag tcgtatccga 6060
agcgttagat cacttactcg ccatgcttga aagcgcctca tgcttttcgc tgattcatta 6120
gctctatgta tggcaatcta agtacgaagt ctgtcgtaag gcttaaaaac taaatattgg 6180
tagctacctt agttaaggtg caaggattgc acaattcagt aggcgttttc tctgctattc 6240
ccgagcggga agctttatca agacaaagct tgatatccca cgggatgaac cagaagctct 6300
atgatatctc agaagctact aaacttcggg ggttgggtac aagttagttg aacatacaaa 6360
tgggaatttg attgtgtcct tggtcgattc tgaacaaatc gtagtgaacc cgtgcaaagt 6420
atacatatta attcatacgg cgtctcaaag aggcaatggc ttgacttgag ctggattaca 6480
gattatgagt aaccgcaaga tagagtaaac actgtaatcc atgcttaatt gagaccactt 6540
aaagatgctg ataccatttt caaaacacga tggtttgttg acaattattt gtacaccgac 6600
gcatcttgcg gttcttggtc gaccctactt acggtataaa tgaagcacgt ttcatccaga 6660
ctcatccatc gtagctccaa atacggattc aacttggcgt ttatatccag aaaagggccc 6720
tagaggtgat agactcttaa gtctttggac taccatggga tatgtttcac gtatcgaaat 6780
agtaaccatt attctgcgtt tgctttcatg caagtgagga tgaagccttt gtattggttt 6840
cttaatcctc ctataccacg cgtgtatctt tcccggccct tcattgaatc cggaagtgtc 6900
ttgttactca atgtcaaacc cttgtcagcc tcttgcggtg atgcacgaaa aaaccgaatg 6960
gaatataaaa tattaactac tcctaatttt aagtgccctc ttctagattg gattcatata 7020
tcaatataga cttcgcaagc tagtgaatga ggggtatgaa tttatccgga ataacaaaag 7080
ggactgagta ttcgagatac gaaccgttag atagatgctc cagtctgcat agtgaatttt 7140
tgatttttaa ccattgaagg aatcaacttc acgaccctta cgagttaagt catcagaaga 7200
agagaccatc agcgctcccc ccttgaaata gtacagcttc aaacaatagc ctgagtaagt 7260
tggtatccga ggtactataa acttctcgac catttgatgc ccccaaccta tgtttaaaga 7320
actattatct ttagccttaa gctaacacag gaaccagctg agtcttgcct agcctcactt 7380
gggctggtta catatataaa ataatgtatg ccgcagaatc tgtcccttag cgaattgtag 7440
ttgaccaaaa gtctattact cattggcgtt gtgtcacttt tgtgtcaata ggtatgatca 7500
atctcttgga aatttttacg acgatggtaa aagattagaa ctactaaaca actgttaata 7560
atcatgtcgc tccgtagatt gccaagaatc agttgggatg agtacgttat ttacgacgta 7620
caagctgcga ctgagttgga ctatgattaa taagaggttg attacatcct gattgcatgg 7680
actgcgatca cgttttgtaa gttcactggg actgttacgc ttaactgctc ggaattcgag 7740
aaaatatacg actgttcgta agagcgcttt gatcgaacac gatcataaca gggcacacat 7800
gataatcatc acttttttag tccctattac agagcagccg agtgaatgta tgtctatcgc 7860
tcactatact atttgcgtgt tatagggtaa cctacgaaag tgaaactact tcgtattgct 7920
cgtgttttta attcgtctcc gattaataca ctatactaaa ttttaaagcc agatatatca 7980
atattaaact actcaattta acctaatcct caaacgttct actaaaccgt gtcaatcagt 8040
gtctgcttcc tgaatgaaac tttttcgcca aagtcaacag ttagaaccta aagtcgcttt 8100
cgtccttagc tacatcgatt tctttataca ggcagtaacg tagatccatt ccgtagaacg 8160
gtttttcact tggacatgaa acatttcttt gatctccagg agaaatatga gaaactaaac 8220
acgtcgagta aatacgtatg accattcctc ttgatcgatc caataagtct ctaatgtgtc 8280
cagagttcca acttcttcaa catacgctct aaatatcaaa tccaacagca aatggtaaac 8340
aatgaagacg gtgttgttca agacatcgtt tgctccacta aaataaagct gagtctaatc 8400
gcgtgatttg atttaaaatt tcgatctgta tgactataat ttcgagagat aaactggatt 8460
agctatttgc tagacgattt ggcacagaat gacacagacg aagaactcac tatgaaatgg 8520
cggtttcagt tgccaatgat ggatttcagc gaaactagga agcgatgtgg cttaagaaat 8580
acctctctca ttgcatttag ataaagcatc ttgctgaaaa gagaaccacc ttgtcacctt 8640
ccacgtatgc ttttgttgta ctggttatta ttgcaacttt acctttgtgt tccactccgt 8700
agtggccatc gtcctcctag tcgtgttcaa ctaggtgcat gtcctccctt tcgtcggcca 8760
ccttaccctc gtccacctcg tcgtttgcta cctgcagtcc tgtataaatc acctcgacga 8820
gtcggattag ttgtagtagt taatactata cccttttcga tagtgaaatg tcattggtta 8880
cctaatggtc taatatctgt gaaacaccgt tcacctttgt taatgtaacg ggttgtttct 8940
aaatttgtat atgtgcctta tggaaccctt gcgaataatt acatacattc ctagcattat 9000
atcctagcct gttagaacag aagcaccatt cccatgtaaa cccagcgtct tcatcacatt 9060
gaatactccc accgattaat attgttttta atatatgatg actcgacctt ctaacacaaa 9120
ttttctactg attatttata acaatatgta ccaggattag ccaaggtgcc gagcgcccgt 9180
ggttttgggt actggtgatt ttatttcgac tcaaatctgc gcactaaagt gaattctaaa 9240
gttagacatg cagatattat aggtctctat atgacgtaga cgataatcaa atagctagac 9300
cgtatgttac tgagtctgct tcttgagtga taccttagcc ccctagtcca cggttactag 9360
caaggctagt cttgttcttt cgatacaccg gactgcttat gaagagagta acataaatct 9420
attttgtaga gcgaccttat cctaggtcat gaaacatttc gttcatctct aagaatatta 9480
caagacatca agtagcccaa gatttttcgt ttgctcctga ttaatccacg cacccgtttt 9540
cggatcggtg taaagattca tcttagtcta tttgatacta tccaaatata ccctaggcac 9600
gcggtcagac gcattatgag actctcttac tgttaggtta ggtgttgttc gatactgggt 9660
gtctgccaat acctcatatt gcccacagtg ccgaatttaa atcggtcaaa ttaggtcctc 9720
aaagttgtaa cgccatcccc acattgttgg gtggtgaccg gtaggtgtac aataatataa 9780
ggtattgaaa attgaattaa atatactttg cgcccgttct acatgaaaca aactcagtcg 9840
aacgatgcaa gaatctgcat tcgaaccaag ttatgagcgc gaactcctat ttaaagtttt 9900
tgtcgctcag aaacctgagg gtttaacaac gttttacgtg ggacatgcga accccttgcc 9960
aatgtcgaaa tataggaatg aacaaatctg tcttcgtgct aagggtgcaa ttaggacgct 10020
gaagtaatgt aacttatatg caaggcaaat tatagcaaaa actaaattcc agtaaggtgg 10080
aagattgtga tttaaagatg actaataaat attgttgtac atcctcctaa tcggttctgc 10140
ggtttacgag caccagaatc caagacctct aaaatagagc taagtttaga cgcgcgatta 10200
tacttaagat atcaagctgt tcgtctattg tatccaggga tattctgtat cccttatcaa 10260
tctatcgatc tcgtatacaa tgactcattt atagaactca gtatagaatc taaggatcgg 10320
gcgccaacga tccttccgat cagaacatga aagctatgtg gtctgacgat tacttctctc 10380
aatgtcttta gaaaaaaaat cccgctgcaa taggatccag cacttagtaa agcaggttgt 10440
gaatcttgta atgttttgaa gatcattgga tcttaaaaac caaacgtgga ccgattagaa 10500
acgtaagcta agatctagcc acatttctaa ctagtctcag gtaaattata ataggtttat 10560
atggtacgcg taccccgttc tgcataatac tttaagagaa aggcaatcca atgttgatca 10620
agctctgaat tacaaacgat tatgatgtaa taggggtgtt atggcttaca tcaagccaga 10680
gatttttagg agtatcaacg ttgcccctcg gctctaataa ctcactagtg gtcatcgaca 10740
tgataatata ttcgataatt tctaactagt ttcatttgta tggcgggcat aatatattta 10800
gtttgagtct gcttgcaacg atgttaggca taagcctggt tcaatactcg cgcttaaagg 10860
gtaatttcga aaacagcgag tgtttggtgt cccaaatggt tactaagtgc accctgtacg 10920
ctagcatgac ggttgctact ttatacccat tcttcaatag acagaaagaa gattctctcg 10980
ttaattttcc aacttcttta cgttgtatat acgttccctt taatttcctg ctagaattaa 11040
ggacattcca tcgtctaaca ctgagtttct actgatttat tataacaaca tgtaggcgga 11100
ttaggcaaga cccgaaatgc tggttgtctt tggctctgga tattttttct cgaactatgc 11160
ctgcgcgttg atatgaatcc tatggatcta caggcagaaa agataagtcg gtttaagaca 11220
atgggaaaag ttagatacct agagtattaa ttatcgagca aatatcttct catatatgat 11280
agattcccac cccccggttg ctaggaaggt tagtcttgta gtttccatag acctgactgc 11340
taaagaggag agttcctgat atcttttttt tagggcgacg tgatcctaga tggcgattca 11400
aatggaccaa catttagaac gtcacaattc ttctagttac ctagtatttt tattttgcac 11460
ctgggaaatc attgcttttg attctagatc tgtgtaaagg ttgatcagac ttgaatcaaa 11520
tttgtccaaa ttatccatgt gcatgagaca gcatatatta tgaaattcac ttttcaaaag 11580
gtcacaacta gttggggact tattgtttgc taatattaca ttgtcctcac attagcgatt 11640
gtagctggct ctctaaaaat cgtcgtagta ccaatgggga gccgagatca ttgagtgatt 11700
accagcagct agactatcta acgagctatt agaggttgat caaagcagac ataccgcctg 11760
aaatatataa atcatagtca gaccaacatt gctacaactc gtattcgcac caacttttgg 11820
ccgcgtattt cccatttaag cttttgttgc tcacagaaca cttggtatac ctatcaatct 11880
catgggacat gcgatcgtac tgtgtacgga ggtgtttcgg taagaagcta tgtcactttt 11940
atctaagtaa gcggataaaa agacaaaaaa acgcaatata tatgcaaggg aaattaatgg 12000
acggtcttaa ttcctgtaag gtaacacacc gtgacccaaa agtcattaag tgatataatt 12060
gtacatctgg ccaatccgtt ctgggctctt caaccaacag taacgggggc ttattaagaa 12120
gattttgata cggacgcgca actgtcgtca ggtaactttg aagtccgtct tttcggatcg 12180
gccaaattcg ctcacctttt tgaatcttcg gatgtcataa ctaatagctc gtttatagaa 12240
gagtatacac tgtctaaggg tggagggcca agaatccttc caattaccac attaaagata 12300
tctgcactga cgtctcctct tctcaaggac aaaagtaaaa aagtgccatt gcactaggac 12360
ttaccgcaaa gattacctcg ttgcatatat tgcagcctta aggacatcaa tggatcataa 12420
aaataaaaca tgcatcctct actgttaaaa tctaagttct agacaaacta ccaattagtc 12480
tgaacttaca ttaaagagat ttagtaggta cacggtctct gtcgtataaa ttactttaac 12540
tgaaatgttt tccagtatta gtcaatccct gaatagcata caattataat gagactagac 12600
tataaacgtt agcgacgaca gagaggttgt tagcggcatc atagttacct ctccgctcca 12660
gtaccacaca aatggtcgcc gatcagatag attggtcggt aatctccgtg agctatcgtc 12720
tgcatggcgg actttataga tctagtatca gtctggttta aatgatgctg agcattagtg 12780
tgcttaaaaa ccgtcacata aagcgtatat tcgaaaacaa cgagtgtcct gtgaaccata 12840
tgcataacta gagtactccg cagactagta tgacacatgg ctccgcgagg ctatttatcg 12900
atacaatatg aatagatata ttcggctatt tttctgttta tatccgtaat atttacgttg 12960
tttttaattg cttgccagag ttaaagacgt tccatagcgt ggaaccgggt tctgggtttt 13020
tcgctatata agcctgatga ctacttcggc tagtcccgac aagttagttc tgaatgccct 13080
cgaataatac tcctaaaaca atgcctggct gttggcagca gtgcattgaa acttcaggca 13140
gaaaggccta gccggcttaa ccaagtggaa aaacttagaa gcgtcctatt atgattatcg 13200
gggaaataca ttctcatttg tgacggattt ccacctccgg atactcagaa aggttatagg 13260
aataattact attgaggtga gtacagtgga gatgatgtca tgtttacatt atatggcggt 13320
aacgtgatcc tgaatgccgc ttatgacaga gtaatgtatt taacgtcgga gtccctgtag 13380
ttatctagta tttatatctc gaatacagga gataacattt taacactcaa gaattgtttc 13440
atgcataatc agtcttgaat gtgattactc taatccatca acgtgtcaaa gacagtatat 13500
ctaatcaagt aaagtctaga aaaaggcata atcagttacg gagttatccc atcttaatat 13560
tactctgatg taatatttgc agtcgctgct gtctctccaa cattcgccgt aacatcaata 13620
gagaggcaag ctcttgctat gtttttcaag ggcatgtcta actatccaat accggttctt 13680
attagaactt cttttacaca atttagtaag gcatatgcct tacccatttt cctttagttt 13740
actttttcta acccgatgtt aattcgcata attagcacgt gcacgtcgtt cttctctttt 13800
agttctttta gttgttctgt atctgcacgt acctgtgcaa cgtccgcttt tattacttgg 13860
tctagtgctt cgtttaaacc gtctaaaagg cctaaaggag gttctgaaac atcgacttcg 13920
tcctggttca ccttggcctc aataatggta gcggctgctt atcatcaaat gaaggaggga 13980
cacccgggga ggactttacg gtggatatcc cgtacaactt cggctaatca tgttatctaa 14040
ataagttggg gtttgcagtt gtgagggccg aatcagattc gactatacag cgcagttcag 14100
agccctaact cacgtaatcg tggcctaaca gaccgagtca agctgataac ccatcgagta 14160
gctcaatatg agcgactgtg aataagaaat ttattgcaag gcaataatcc tgatcattga 14220
ctccaaactt tgataaggat gaagattagc acaattgaga aagcgtactt actgtcatgc 14280
tcgaatgaaa tgctctatta aagaataggt tgacgtccta cgagaaggtt aagaacttct 14340
cctgcatctc acaacctaca taatcttcgg gcatgggtaa tagacgggtg aacatataaa 14400
tacacaaaag tttcttcctt catacgtagc taagcaagtc atagctatac cccacaaacc 14460
tttcataatc actgtatcgg gttatctaag agctagtggc atggctagtc atctatggta 14520
atatgtcagt taagtcaaga tgcggtaaat tgtgtattgc ggctcctatt gtcccgactt 14580
aaactgtctg accgtatcag attaaccacc tgatcctaat tgcctattga cagaacaaag 14640
agccacactc agggagcagt cgacggacgc caccacgtgc attttcggct aatcttataa 14700
tctataaatg ttgaggttta cagttctcgg ggcgagatca aatttaagta tatagtcctg 14760
tccgaagcct taattcacat attcgccacg cttgaaagcg cgtcatgctt ttcgctgatt 14820
cactagctct atgtgtggca atctaagtag gaagtctgtc gcaaggctta aaaactaaat 14880
attggtagct accttagtta aggtacaagg attgcacacc acggagcata agtaaaagga 14940
tttgtattaa tagaaccagg accatcacca ttcaagttac acggtggtca actacttctg 15000
ctgcgttatc gttctgtatt cctaaatcga atggttgttc gacttttagt atttctgtat 15060
aagttcaacc tgttttgacg ctctctgctt aagaagtcaa gtaaatatgt atcacctttc 15120
accatctaag tgaggatgta gcctttgtat tggtttctta atcctgttat accaggcgtg 15180
tatctttcct agcgctttat tcaacctgga actgtcttgt tactcaatgt caaacccttg 15240
tcagccactt gcggtggtgc acgaaaaaac cgattggaat attaaatatt aacaactcca 15300
aattttaaga gccctgctct agtttggatt catatatcag tatagacttc gcaatctagt 15360
gaatgagcgg tatgaatttt cgcggaatat gaaaagcgac tgagtattcg agatacaaac 15420
cgttagatag atgctccagt ctgcattctg aatttttgat ttttaaccat cgaaggaatc 15480
aatttcacga ccctaacgag ttaagtcatc agaagaagag accatcaggg ctcccccctt 15540
gaaatagtac agcttcaaac tatagcctgc gcaacttggt atccgaggta ctatagactt 15600
ctcgatcatt tgaagccccc aacccatgtt caaagaacta ttatgtttag ccttaagcta 15660
acacaggaac cagctgagtc ttgcctagcg tcacttgggc acgttacata tataaaataa 15720
tgtatgccgc agagtctgtc ccttaccgaa ctgtagttga cctaaagtct attactcatt 15780
ggcgttgtat cacttttgtg tcaataggta tgatcaatct cttggaaatt tttacgacca 15840
tggtaaaaga ttagaactac taaacaactg ttaataatca tgtcgctccg tagattgcca 15900
agaatcagtt gggatgaata cgttatttac atcgtacaaa ctgcgtctga gtaggtacca 15960
tcgtagttta tgcctatgtt ggaccgcaaa tatacgtctt ttgccgggat ccccactatc 16020
tgtgaaatgt gaaacctgtt ggttacctat acaaaataca tagctatatc attggtaata 16080
atatgttaac ggaagatcgt tcactctttc ttcggaaaga ta 16122
<210> 343
<211> 14606
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV5
<400> 343
cctagggtat tttacgttag catcaggtgg actaacatga atctttactc ccaagcgaaa 60
acgggtgcgt ggactagcga ggagcaaacg aaaattcttg gcctgcttgg tgtctcgtat 120
ttctcttaga gatcgacgaa atgtttcatg accaagggaa aggtcgccct acaaaataga 180
tttgcgttac tctctccata aggagtccgg tgtagcgaag gatcaaggcg accctaggta 240
gcaaccgccg gcttcggcgg taaggtatca ctcaagaagc agacacagta agacacggtc 300
tagctgattg tttatcggct aggtcaaata gagagctttg atatctgcat gtctagcttt 360
agaattcagt ttagtgcgct gatctgagtc gagataaaat caccagtacc caaaaccagg 420
ggggctcgcc acgttggcta atcctggtac attttgtaat caatattcag tagaaaattt 480
gtgttagaag gacgagtcac catgtaccaa tagcaataac gatcggtcgg actattcatt 540
gtggtgatga cgctgggttt acatgggaaa ggtgcttgtg tcccgacagg ctaggatata 600
atgctgaggc ctttccccaa acgttcagcg tgggatttgc tacaacttct gagtcctaca 660
tgtacgtgtt catgttatgt atgcacaagg ccgagaatag gacgtagcct tcgagttagt 720
acgtagcgtg gtcgcataag cacagtagat cctccccgcg catcctattt attaagttaa 780
ttctaaagca atacgatcat atgtggatgg gcagtggccg gttgttacac gtctaccgcg 840
gtgctgaatg accgggacta aagaggcgaa gattatggtg tgtgacccgt tatgctcgag 900
ttcggtcagt gcgtcattgc aagtagtcga ttgctttctc aatctccgag cgatttagcg 960
tgacagcccc agggaaccca taaaatgtga tcgcagtcca ggaccgaagc atactgcaag 1020
acttgtaggc ccatgaatta cccgcttagg caatgggtag acctttcctt gccgcgtgga 1080
acaaaccgcc atgagtgttt tacgtttacg gtcggcgacc ggagtcacag cgcgaccaac 1140
ggggccaggg tgttaccctg atgaatattc aacggaattg ctataggcct tgaacgctac 1200
acggacgata cgaaattatg tatagaccgg gtcatcaaaa ggttatactc ttgtagttaa 1260
catgtagccc ggccctatta gtacagtagt gccttgaatg acattctctt tattaaattt 1320
tctctacagc taaacgatca agtgcatttc cacagagcgc gatggagatt cattcactcg 1380
gcagctctgt aatagggact aaaaaagtga tgataatcat gagtgccgcg ttatggtggt 1440
gtcggaacag agcggtctta cggccagtcg tataccttct cgagttccgt ccagttaagc 1500
gtgacagtcc cagtgtaccc acaaaccgtg atggctgtgc ttggagtcaa tcgcaagtag 1560
gatggtctcc agacaccggg gcaccagttt tcacgccgaa agcataaacg acgagcagat 1620
atgaaagtgt tagaactgga cgtgccgttt ctctgcgaaa aatacctcga gctgtagcgt 1680
tgttgcgctg cctagatgca gtgttgctca tatcacattt gcttcaacga ctgccgcctt 1740
cgctgtatcc ctagacactt aacaataagc gctttttgta ggcaggggca ccccctatca 1800
gtgactgcgc caaaatatct tcggatcccc ttgtccaatc aaattcatcg aattcttaca 1860
tttaagaccc taatatcaca tcattagtga ttaattgcca ctgccaaaat tctgtctaga 1920
aataggagga agccttttag ccatcgctat gccgccgctc aaacgcgccg ggtgcaaaag 1980
cccagagcaa aggcccatag gcttttccat cggcacgcga ccgattccat caagtatagc 2040
cacggtcgta acttcgacgg cggcaatagt ttatggcgct aacacctttc catcgctgag 2100
tccaaacgta tgacgtgagg tgttaggtgc aatccccatt cgggacggac acgcgagtaa 2160
aggtctaaca tgtttcaact ttccagttag tcgccgtcct atattggcaa gaccggatgg 2220
ccgtcaacca gttccattct gactatttgc cacattgatt aaagaagtag gagcgttagt 2280
cggcgcgtgc gcgggactat ttagcgaagg tcgccgtatc gcgggtggcg gcgtttccgc 2340
cataacaaca agcgtttaag gtcagagtcc gcgacgaatg aaacgccgtg caagcggctt 2400
tggtacggcc agtttagcca aagcctgatc cgttcgcctt gggttatcat gtaccagtca 2460
agcggtcatc gcgggcggcg ttatcatggt aagggcgtcg aacggtcgtg aaagtcttag 2520
taccacacgt accaacttac tgaggatatt gcttgaagct gtaccgtttt agggggggaa 2580
ggttgaagat ctcttcttct catgactgaa ctcgcgaggg tcgtgttgtc ggttccttca 2640
aaggttaaag aacaaaggct tactgtgcgc agaggaacgc ccatttagcg gctggcgttt 2700
tgaatcctcg gtcccctttg tctatccaga ttaatccaat tccctcattt aggaccttac 2760
caagtcaaca ttggtatatg aatgcgacct tgaagaggcc gcttaaaaat gacagtggtt 2820
gatgctctaa acttcatttg gttaactcgt gtatcagcgc gataggctgt tagaggttta 2880
atattgtata gcaaggtact tccggtctta atgaatggcc gggaaaggta cgcacgcggt 2940
atgggagggt gaaggggcga atagacaggc tcctctctca ctcgctagga ggcaattgta 3000
taagaatgca tactgcatcg atacataaaa cgtctccatc gcttgcccaa attgtaaagt 3060
gtctatcacc cctaggcccg tttcccgcat attaacgcct gattgtatcc gcatttgatg 3120
ctaccgtggt tgagtcagcg tcgagcacgc ggcatttatt gcatgagtag agttgactaa 3180
gagccgttag atgcctcgct gtactaatag ttgtcgacag atcgtcaaga ttagaaaacg 3240
gtagcagcat tatcggaggt tctctaacta gtatggatag ccgtgtcttc actgtgagga 3300
tcgtttgccc gtaaaactaa ctggcaaaag cctaagtgct gtttcgggtg caatggtata 3360
acttcccaca tttagccgaa tagcgccaac agcgttatta tttggtccca cccccgcagc 3420
ttgccagctc tttgagtatc atggagccta tggttgaatg agtccaataa cgaacttcga 3480
caggaaccaa gcagtgggcg atgtcagcga caattccact ttggtagagg tcgttctttt 3540
gtagaaaaca atctaacata actatgacac tttcggtaaa ttcaccacct ttaccagggt 3600
cgtaagtggt caagccacgc cgaccacttc ataagcattg gtggtttata acttgttgcg 3660
ttcctagccg ctatatttgt ctctttgccg actaatgaga acaaccacac catagcgatt 3720
taacgcagcg cctcggaata ccgtatcagc aggcgcctcg taagaccatt gcgaatacca 3780
ggtatcgtgt aagtagcgta ggcccatacg cgagataaac tgctaggaaa ccgcgtctct 3840
acgaccggtg ctcgatttaa tttcgctgac gtgatgacat tccaggcagt gcctctgctg 3900
ccgggtccct ctcgtgattg ggtagttgga catgcccttg aaagatatag caagagcctg 3960
cctgtctatt gatgtcacgg cgaaagtcgg ggagacagca gcggctgcag acattatatc 4020
ggaataacac taaggtgaga taactccgta actgactacg cctttctcta gactttactt 4080
gaccagatac agtgtctttg acacgtttat ggattacagc aatcacatcc aagactggct 4140
atgcacgaag caactcttga gtgttaaaat gttgactcct gtatttggga tgcgggtagt 4200
agatgactgc agggactccg acgttaagta cattaccctc tcataggcgg cgttctagat 4260
cacgttaccg ccatatcatc cgagcatgac atcatctccg ctgtgcccat cctagtagtc 4320
attattccta taaccctttt gagtgtccgg tggcggatat cccccacgaa tgaaaatgtt 4380
tttcgctgac aatcataatg gggcgctcct aagcttttcc acttggttgg gccagctagg 4440
cctctctgcc cggagtttcg gcgcagtgct gccgacagcc gggcattgtt tttggggcgt 4500
tattcgaggg cactcggacc taacttgtcg ggaccacccg gggtagtcat cgggcttata 4560
cagcgaaaag cccagcaccc ggctcctcgc tatggaaggt cattagctcc ggcaagcaat 4620
taagaacaac gcaaggatcg cggatataaa cagagaaacg gccgaataca cctgttcgta 4680
tcgtatcggt aaatagcctc gcggagccat gtgccatact cgtctgcgga gcactctggt 4740
aatgcatatg gtccacagga cattcgtcgc ttccggatat gcgctctatg tgacggtctt 4800
ttggcgcaca aatgctcagc accatttaaa ttagaccgac tccagatctg taaggtccgc 4860
cacgcagacg acagcccacg gagatcactg accgatctat ctgaacggcg accatttgtg 4920
tggtactggg gcggagagat aactacggtg ccgcttacaa cccctctgtc gtcgctgacg 4980
tttgtagtct agtctcatta tgattgtacg ctattcaggg attgactgat accggaagac 5040
atctcaaatg aagtggtcta tacgacagag accgtgcacc taccaaatct ccttagtgta 5100
agttcagacc aattcgtact ttgttcagaa ctcacatttt aacaacagag gacacatgct 5160
ctaccttcat gatctattga cgtccctgag gctgcaatac atgtaacgag gcagtatccg 5220
cggtaagtcc tagtgcaatg gcggtttttt accctcgtcc tggagaagag gggacgccag 5280
tgcagttatc attaatgtgg aaattgggag gactcttggc cctccgcctt taggcagtgc 5340
ttactctttc ataaaggggc tgttagttat ggcctgcgag gaaatcgcat cgacacaata 5400
aaagtacacc aaccagcaga aaacaggtac atatacagtt taacgacctg gttcttaccg 5460
gagcgcctcc gtacacagta cgatcgcacg ccccatgaga tcaatacgta taccaggtgt 5520
cctgtgagca acaaaagcct aaggatctaa gatgactaca gtagcatagc catagaacat 5580
ggcactgaaa tatcgatggg cgtaaaagtg aacaacgcag acgatggtag gaggagtcgt 5640
cagaccagat agctttgatg tcctgatcgg aaggatcgtt ggcccccgac ccttagactc 5700
tgtactcagt tctataaacg agccattgga tacgagatcc gtagattgat aagggacaca 5760
gaatatcccc ggatgcaata gacggacagc ttggtatcct aagcacagtc gcgcgtccga 5820
atctagctct actttagagg ccccggattc tgatggtcgt agaccgcaga accgattggg 5880
gggatgtaca acaatatttg ttagtcacct ttgggtcacg atctgctacc ttactggaat 5940
ttagtccgtc ctataatttc ccttgcatat aagttgcgtt acttcagcct cctaactgca 6000
cccttagcac gaagacagat ttgttcttac ccatactcca ccgttggcag ggggatcgca 6060
tgtcccacgt gaaacattgc taaaccctca ggtttctgag cgacaaaaga ggattacgac 6120
gccaagccac tataaatgct aattgagtcg aagaaggtac tcctttttgg tatttgtgct 6180
actctcctca taagcagtcc ggtgtatcga aagtacaaga ctagccttgc tagcaaccgc 6240
gggctgggag cctaaggtat cactcaagaa acaggctcgg taacatacgc tctagctatc 6300
tgactatccc ctacgtcata tagggaggaa cacagatatt gcagaagcgg gaatgaggtt 6360
gatattacat caagtatcaa cagacgacct cagaagggtg gtcttttaaa atgacaacgt 6420
acattaagat gcagacaaac actactatgc tggttaccgt gacagccgca cggatcccat 6480
ataatgcaat cgtagtctac ctgattgtac ttagaaatgt ggcttcgctt ttgcccacgc 6540
acctgatcgc tcctcgtttg cttttaagaa ccggacgaac cacagagcat tagaagaatc 6600
tctagctgct ttacaaagta ctggttcctt ttccagcggg atgttttatc taaacgagga 6660
tgtgaaaatg tcatatgtgc ggcaaaaata gacgacattt aagaacctag cattatagga 6720
tggttacatg gttttcgtta ttgctagcca gcctcataag taacaccact actgcgaccc 6780
aaatgcaccc tttccacgaa cacagggttg tccgatccta tattaggagt gttgtattaa 6840
ttcactctag agtaatggat cacggtgcca gaaactaagg tggtgtagga ctagatgcaa 6900
gtaacaacgg tcgtactaaa atcagctacg cgatcgccga cttagaaggc tgagatggtt 6960
gcataaggag accggtgtag ccaaggacga aagcgaccct aggttctaac cgtcgacttt 7020
ggcggtaagg tatcactcag gaagcagaca ctgatagaca cggtttagca gatcgtttga 7080
cgactaggtc aaattgagtg gtttaatatc ggcatgtctg gctttaaaat tcagtatagt 7140
gcaggagaaa cttgtctact ggcagacctc actatctttt aggaaggtca cgaagcggct 7200
ggagtgatgg ctagtctcag ccactgtcaa cgggaagcgc gacgtttatg gtcaatataa 7260
actagcagtt taatccgtat ggcgatctta gcggatgtta caggatggtg gaagctaata 7320
gcgccggtga gagcgtaatc tgccgtctcc accaacacaa cgctatcggg tcatattata 7380
agattccgca atgggattac ttataagtag ccttaacgat atccggaact tgcgatgtac 7440
gtgctatgct ttaatacata cctggcccag tagttttcca atatgagaac atcaattgta 7500
catcgggccg ggataatcat gtcatcacgg aagtaactgt aagacaaata attcaaaaga 7560
gatgtcgttt tgctagttca cgtaaaggtg tctcgcgcca cctctaagta agtgagccgt 7620
cgagacatta tccctgattt tttcactact attagtactc acggcgcaat accaccacaa 7680
ggagaagatg acaaagtaga agctagacaa ctatatcaaa tcgttgtgtg gtcttaaacc 7740
gacacagtag cattcatcgt tggtcgaaaa acatccgtcc ccgaggggga tagtcactga 7800
cgcggttttg tagaagccta ggggaacagg ttagtttgag tagcttaaga atgtaaattc 7860
tgggattaag gatgtggaag gtcacagcct cgttggagga gatactacgg tcccgctttt 7920
cgtgggtgac aaaggtcgca aaggtttcct tagggaggtc gtttcccgga tctttatcta 7980
catctcctgg gtgaagggga tgatctttct ctacatgtcc tgggtggagg ggagtttcct 8040
tgtatgggtg gaacccaacc cgccggtgag ggtgagttac ggtcggcggt catatgtggg 8100
tatgacgggt atgacgtcat aaatagtcgt tgtcaaaatg ggaggtggaa gtccttactg 8160
tagtcacccg tgaaggtgga gaactggcag gacatctcta ggtcacctaa acgtgcgaag 8220
tgtgcgaaat taccaccgta aattcgtcct actgaaagtg cttacgcatc ttgagagaga 8280
ttgcagagag ccaggtcaaa tacattgaga aatctgtata tgtactttgg taacgctcta 8340
aggtaggtac acgttagtga tataaaaaga aggcgacgac ggtagcagag gtctagaaac 8400
cgcatgaacg accaacttat ttgaagagct agtgcggtgg aattgggtcg gaagaactta 8460
aattgttaga gcagtttatg ggtggtaggt tacatctatt tacttcaaaa cgcggtgccc 8520
tagcccacaa gcattgcttt gtaaaattgt tgaaggtaac ttgtaaaagc cgaacatgaa 8580
cgatggtagc taagagtagg ccgggagtgt agacctttgg ggttgaataa atctattgta 8640
ctaatcggct tcaacgagcc gtacaggtgg cacttcagga ggggcccgca gggaggaagt 8700
aaactgctat tcgtcgccgt tggtggtaac taattgtgtt ccttgccact acaattgtat 8760
ctaagccgtg taatgagaac aaccacacct tagcgaattg atgcgccgct tcggaatacc 8820
gttttggcta cccgttacta agcccatcgc gattttcagg tatcgtgcat gtagggttgg 8880
accgcacgca tgttaaactg ctggcgaagt gcgattccac gaccggtgta cgatttaatt 8940
acgccgacgt gacgagtttc ctgttaatgc ttcacccgcc ggaccgccct cgtgatgggg 9000
tagctgcaca tgagcttatg acaaataacg agagtgtact tgtttaatca tctcacggtg 9060
aaagtcggga gaacagcagc cgctacacac attttaccgc aactacactt agctgagata 9120
tttccataga tgactacgca tccctctaga ccttacataa ccggatacag tgactttgac 9180
aggtttgtgg gatacagcaa tgacttgcat agctgcgtat ggaggaagga actcttgtgt 9240
gttaatatgt tgacccctgt attacggatg cgggtagaag atgtgggcag agacacccag 9300
gtcaagttct taaccttctc gtaggaggtg ttccagttca ccatacgacc atatcattcg 9360
agcatgacac tatgtacgct gtccccattc tggtagtcat catccctatc acggtttcga 9420
gtgagtggtg acggatattc cccacgaatg aatatcttat tcacagtcgg tcatattggg 9480
gtactccttg gcttttccac ttggctcggt ctgttaggcc tccgtagcgt gagtttcggc 9540
cctgtgctgc ccagtgtcgg ccattctcat tggggcctca cttctggata ccccgaccta 9600
ttttgacggc accattggcg gaagttgttg ggcttatgca ccgtaaagtc ctccgcgggc 9660
ctccccccta caaaagatga taagctccgg caagcaatat tgatcaacgc aaggatcggc 9720
gatataaaca gagaaacggc tgattactct tgttggtgtg gtatcgctaa attgcgtcgc 9780
ggagccttat ggcatagtcg tccgcggagc attctggtaa cgcttatggt ccatagcaca 9840
ttcatcgcat ccgggcatgc gctctatttg acgatccttt ggcgcagaga tgctggccac 9900
gtgctaaatt aaagcgactg cactactgta aggtccgtca cggagacgac ggcccgggga 9960
gagcactaac ccatcaacct gtacgggaac attctatatc gttctcggac ggacagatta 10020
ctagagtgcc gctttcagcc cctctgtcgt cgccgacgtc tgtaatatag cgttgttgtg 10080
attccactct attgaggcat taactgatgc ggaaggagat ctggaatgaa ctggtctatg 10140
tcacagaaac tgtgcaaata cctaatgtcg ttagtgtagg ttctgaccga tacgtgcttc 10200
gttgagaact cacaatttta caactgggga cataaaccct acgcccatca tctactgacg 10260
tccctgaggc tccagttcat gtaatgggag agtatccgcc gcaagatcta gtgcaatggt 10320
ggtatagtaa gctcgtactg tagtagaggc gacacgggta ggatcatcag taataaggat 10380
agtgggaaaa ctcacagacc accgcctata gggggtgctt acttttacaa aaagcgactg 10440
ttagtataac cccacgagga ttcgaaaagg tgaaccaacc cggtcgatcc ggagggacgg 10500
gcctcaaagc cgcgtcacga cggctgtcgg cccgtaacag aaaccccgga ataagctccc 10560
gtgagcctgg atagaacagc cctggtgggc cccatcagta gcccgaatat gtcgcttttc 10620
gggacgtggg ccgaggagcg ataccttcca ctaatcgagg ccgttcgtta atacttgttg 10680
cgttcctagc gcctatattt gtctctttgc cggcttatgt ggacaagcat agcatagcca 10740
tttatcggag cgcctcggta cacggtatga gcagacgcct cgtgagacca ttacgtatac 10800
caggtgtcct gtaagcagcg aaggcccata cgcgagatac actgccagaa aaccgcagga 10860
tagtagaccg ggaagaccaa cgttttttca ctactccgaa agaacacact gaagggaacg 10920
gtgtaggttc ggtgagtccg ggactaggtg tccatgtcgg agacctcagt ggtgacgtcc 10980
tcgtagtata ggtttaccgc caaaaaatgg gagcaagacc tcttctcccc tgcggtcacg 11040
tcaatagtaa ttacaccttt aaccctcctg agaaccggga ggcggaaatc cgtcacgaat 11100
gagaaagtat ttccccgaca atcaatacgg gaggtccacg ctctaagtcg cttgcccaat 11160
tgtggctacc gcattgctca gaacttcggg tactggccaa ccttcaagaa gcctagtctt 11220
ggtgcgtcac cccagtcacg tagcataccc gtcatcatct atggtcgtag gtccaacaat 11280
cgtggcgcca ttgggtacca cttcatcaga gctgctcgca tgaccagcta tatctggaac 11340
atcgctggtg ggtcttatgg tcgcttttgt gggaaccatc atagtcgcaa gtctggcctt 11400
cggtatggaa ctcgtcgtcc cgactacaac catagctagt ctcggtctcg gctttgttgc 11460
aatgcccttc gttactactt caacggtcgt ggtgccggtc aaaccgctcg ctaaagcaag 11520
cgaagaaaca gctaaactta gttgtgtcga aacatcctaa gtggtcgggt tgctcgtgga 11580
gcatgcagct agcccagaac ctttagcttg tgtggtcttc gtctcggtag tcagaaccag 11640
gtcggtctga atggttggac tcgccacatc aactaggtca gctattgaag tgccaactaa 11700
aggtcgtatt gaagcaatcg gtcctatggc aagtcaagtg acagtcgtag gtatggcact 11760
tgccgcgcct ccagaactcg gtcaagctac ctcataactc ggaagtcgac tgctctaaag 11820
cgaagttgtc aaacgaacag ctatgccttc gagtaaagca aggtgcgcaa tagtaacctt 11880
ggtaacttcg gaactgcgtc aagccgctaa ctccatcggt atggaagtcg ctaaagtcgg 11940
tcaaacggaa gcggctatcg tcgcaactag tcgaatagtt gtcgaagagg ccagagcaac 12000
catggttgcc attgtcttcg tggtctatgc aagacgtcct tgcgtcatgg cctaagcatc 12060
ttcttcactg gttgctatag cggaagtcgt taccgaactg gtcgccagtc gaatcgtttg 12120
ccccatggta gtcatcacca ccatcgcgga aaccaacggt ccgaactcac ggtaggtagt 12180
ccacgtatgt agcccacctt tcgaaggaat cgtggtcgcc ggtctcctag aaacggtata 12240
tgtcttgcgt cacgcttatg gaccggtcat cctggccagt agccgacttg tggtcgctat 12300
agctttcgct agtccctgcc ttaacgtgca gcatggtatg gctattgtcg tcccggctac 12360
aaccactatc gtggtcttga aactggtcgt cgctacaacc atcctagcat tggcaccagc 12420
ggtcgttgaa gccgaaggta gtctctaact ggttttcgaa gctagtcaaa cagtagcgcc 12480
atatggccta gcctgaacct tagaaaaagg agtcgaaggt cctaaacccg ctggtcgcga 12540
acgaacaaaa acggtcgtta aaggccgtcc ggaagcggaa ggtcgtcgcc ccaggtgaac 12600
aagtcctaaa gaaacaaaaa gtctctgtag tctatttaaa acccaacgca aacgcgaacg 12660
cagaatcgtc tgaacccacg tccatcatta cggattatat aaggtttctg tttcgttaac 12720
taggtagtta ttgatgtcat ccgcactaca agctaacagg aggtaacaga tagagcatga 12780
gtggtagtag ggatgaaaca ggaagtacta attacataca gggactcctg gttgggtgac 12840
cccgggacac gtacgtgtcc taataaacag gaggcgggtg gtttcctatc tactacggac 12900
agggattttc cccgagtagc gaaggatatg aaacttctag ttatagacat ataagacgta 12960
gtccaggaag tcggctgagt ccatgaggtc agttttggag gagaagtagt tgtcacgatc 13020
cttagttaag ataacaaagt ccgagtagtt atcacgactt gctgactgcg tccactatgt 13080
ttccggggtg ggcatgggga cttgcacacg gataactcca tccggattat taagacgagg 13140
tggggtgtgc tgggctccca ggaacttcat cggagtgacg tagaaccttc agtttgagtc 13200
cacgtaggac accagcgcta ttggtgccga cgacgagtac aaacatccgg aaacttagca 13260
tattaggtaa gagtttctgt atgctcggac gtcgtcgtta gagcagaccc agaaggtgtc 13320
catggacaca catcatacaa gacaacttgg tcaactttta cggggctggg gccaattatc 13380
ccgggagtcc tcacgatcag aaaccgactg gtttgtcaca ctctggttag aggaggggtc 13440
accacgatgg gtgagggggt ggtgggtgtt tatacaagag tctgggactc caaagacgat 13500
attacgacga gacgacttat ccacgtactt tgtttcccaa acccacgcaa ctccaccttt 13560
agtccacaca aactagtacg agacacccgg attcaaggtc gtgaccgacc atgtaaaaca 13620
tttgttacaa gacttctttt aaacactatc ttcctgccca gtagcggatg attatcgttg 13680
ttgctagccg gcgtggaagg taacagcacc gctgcgagcc taatgtgccg tttccacgaa 13740
cacaaggctg tccgatcgta tattaggatt ccgcaatggg gttagcaaat ggcagcctaa 13800
acgatattgg ggacttgcga tgtacatgct ttggtacaat acatacgtgt tccagttgtt 13860
atcctgtatc ggaacatcaa ttatgcatcg gaccagcata ttcatgtcat ctaggagggg 13920
cgcgtaggat aaataattca attaagatgt cgttttgcta gtatacgtct aggcgtcacc 13980
ggccatctgt gtgcagatgg ggcgacgaga cattgaccct gatttctcca cttctaatag 14040
cacacaccgg gcaatacgag ctcaagccag tctcgcagta acgctcatca gcaaacgaaa 14100
gagtttaagg ctcgctaatt cgcactgtca gggtcccttg ggtgttttgc actagcgtca 14160
ggtaggctag tatgtgtttt tccttccagg ggtatgtggc tgcgtggtca aatgtgcggc 14220
atacgtattt gctcgacgtg tttgctctca caaacttgac ctggagatca aggagatgtt 14280
tcttgtccaa ctggacagcg cttcaacgga atggatctac gttacagcct gcataaagaa 14340
aacggagttg ctgaggacga aagcgacttt aggttctgtc tgttgtcttt ggcggaaaac 14400
ttccattcag gaagcagaca ctgattgaca cggtttagca gaaggtttga ggattaggtt 14460
aaattgagtg gtttaatatc ggtatgtctg ggattaaagt atagtatagt gtgttaatcg 14520
gagacgaatt taagacacga gttcccaaaa tcaagcgggc tcattacaac ggttaatcct 14580
ggtagtttac gtgaacaatg tcctga 14606
<210> 344
<211> 12837
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV6
<400> 344
ggcgaataga caggctcgcc tctgtcacgc taggaggcaa ttctataaga atgcatactg 60
catcgataca taaaacgtct cgatcgcttg cgcaacttgt gaagtgtcta tcatccctaa 120
gcccatttcc cgcatattaa cccctgattg tatccgcatt tgatgctacc gtggttgagt 180
tagcgtcgag cacgcgggac ttattgcatg agtagagttg actaagagcc gttagatggc 240
tcgctgaact aatagttgtc gacagatcgt caagattaga aaacggttgt agcattatcg 300
gaggttctct aactagtatc gatagccgtg tcttcactgt gctgcggcta cctatcgcct 360
gaaaaccagt tggtgttaag ggatcccctg tccaggacgc cacacgtagt gaaacataca 420
cgttcgttgg gttcacccgg gtcggatctg agtcgaccaa ggacacactc gagctccgat 480
ccctactgtc gagaaatttg tatcccgccc ccgcagcttg ccagctcttt cagtatcatg 540
gagcccatgg ttgaatgagt ccaataacga acttcgacat gataaaatcc ccccctcgcg 600
acttccagag aagaagacta ctgacttgag cgttcccagc acttcagcca aggaagttac 660
caattttttg tttccgaatg acacgtgtct ccttgcgggt agatcgccga ccgcagaact 720
tacgagccag gggaaacagt aaggcctaat taagtaaagg gagtaagtgt tcgaacgctt 780
cagatgtaac catatactta cgctggatct tctcccgcga attttaaccc tcaccaacta 840
cgagatttga ggtaaaccaa ataagcacgt agtggcgcta tccgactgtt cccaaattgt 900
aacttatcgt tccgtgaagg ccagagttac ttcccggccc tttccatgcg cgcaccatac 960
cctcctagtt ccccggttat ctttccgaag agggagtgag ggcaagacga atctgcgtca 1020
acgctaaagg ccgtcaaaaa gcaagagggc gtcgcgcctg ggaaaaaggt agtcaagaaa 1080
ccatcaagct taaatgtcgg gaaattgggt ttgcgccgcc ttcaggggca gcgatggggg 1140
cgacaattgt ggaccgtatg gactccatta tgctgggact cctcgggtgt aagggagaga 1200
ccctgcggcg tacttcattt tgtatatgca acgtgcccaa gtgacgccag gcaagtctca 1260
gctggttcct gtgttagctc gaggctagac ataggagctg aagggtagtt gttgaaaaag 1320
taggaatatc tagcctagat gtcgtttcag gcgaaggact ctaaggtctt aaaatcgttg 1380
ggtgctcatt cactaggttg cgaagcctat actgatatat gaatccaaac tagagcaggg 1440
ctcttaaaat ttggagttgt aaatacaggt caaccgctct aaagcgaagt tgttggacaa 1500
acagttatgc gtaactgtaa agcaaggtgc ccaagtagac tcttactaat ttgggaacga 1560
cggaaagtcg ctaccttcat cggtatggct ttcgctaaag tcggtcaaat ggaagaaggt 1620
agtcgaagta ctgttgaaag agtagactga gcgacagtcg aaaccagccc caatgaacaa 1680
gacgccattg caaaacgtct atacgctacg gtcaaagacg cttccacacc acatggtata 1740
gtggacgccg ttagcctcat gtgtctcact caaagacctt gcgtcacggt catcctcttt 1800
gtcagcaacg tagaaatctc cggtctgtcg ataccttgcg taaagctctc atgtagccta 1860
ccttacgaag aaatcgcaca agtcggtcgc ccagcggtgg catatgtctt gcctaacgtt 1920
tctagaccga tcagcctcac gagtagcctg cttgtggtgt ttatagttta cgctagtcca 1980
atctgtatcg tgccgcttgg tatggctatt gtcggcctgg atgcaagcac taacgtggtc 2040
atcagactgg tctgcgctat aatctacgca atagaggcac cagcggtcgt tgaagccgaa 2100
gacgctattt cggtggcttg gtcacaagtc aagccattgc ctctctgaga cgccgtatga 2160
attaatatgt aaactttgcg cgggttcact gcgatccgtt cagtctcgtc caagggcaca 2220
atcgaattcc catttgtatg ttcagctaac ttctacccat cccccgaagt ttagtaggtc 2280
gtgaggaata ttgtttcaat ggtcgtggcg ctggtcagac tgctcgctaa agtcgtcgaa 2340
gaaacagcta gaccatctat tctctgaact tcctaagtgg tcgggttggt cgtggcgctc 2400
atagttagcc cagaacgtcc agtttatgtg gtggtgatct tggttgccag actcagtatg 2460
gtcaaaatag ttgtgctcgc catttcaact agtgcagttg ctaaagtgcc aactaaggtt 2520
cgtcttgaag caatcggtag tatctgcagt caagtcgtag tcgtaggtat ggcacttgtc 2580
gtgcgtctag gacgcgttga agctatctta ttgcccgaag gtgagtgtgg ctctttgatc 2640
tgacaacgtg caacctctat cgcgaccgat tgtttctgcg gaccatgttg tcctcatagt 2700
ttgggcatgt ttccgttgta ggagtgaaac cacttagcag gagccgaaag tctgggacac 2760
gtcgtgggac gtatcgttag gactatggga ctagtcgtct tcggtcttac aaatgttgca 2820
atgccctggt acgtttgggg ttgaaaaaat ctattgtacc aatcggcttc aacgtgctcc 2880
acggctggca cctgaggagg ggcccacacc gaggaagtag actgttatac gttggcgatg 2940
gtggtagcta actaagttgc ttgccacaac aacagtatca aagccgtata aagggaacat 3000
ccacacttta gtgaatcgaa gaggcctatg cctcgtatca tctatggtcg taggtaaagc 3060
aatagcggaa acattggatg tgacttcatc aggactgctc gtatagtgag ctacttatga 3120
aacatgaatg gtcggtcttg tggtcgcttt tgtcgaaatc accggttatt gtatgagtag 3180
tgatttgtaa gagttgttag ttagctcgtt caggtaatag ttgcccacac aacgtcaaaa 3240
taagagaacg gtcgtaacat tatccgtgat tttcttacta ctatcagtac tcacgactcg 3300
actctgccgc agctacgtat cgcctgaaag ccagtcagcg ttaaggagtg ctctgagcag 3360
gacaactcgc gtagtgagag ttacatgttc gttgggttct tccgacacgg acctgagttg 3420
gccaacgtcc cacttgaggt ctgtgccccg gtgatgagaa gtatgcatct cgttcttgca 3480
gcttgtcagt actttcagaa tcatggcgtg catggtagaa tgactcttat aacggacttc 3540
gacatggcaa taaccccccg tttctacttc tagaggagaa aagtattgac atgagcgctc 3600
ccggcacaag ggccaaagaa gtctccaatt tcttatttcc gaatgacatg cgtctccttg 3660
cgggtaaatc accgaccgca attcatagaa gcctggggga acagataggt ctaattagct 3720
taagagagta aatcctggga tcattcagta gtaaccataa acttacgctg gggcttcttc 3780
ggcggatttt tacagttacc aaccaggaga tttgaagtaa atcaattgag gatttagccg 3840
cgctatccga taatctccaa attaaaacat accgttccat gaaggctaga attacttacc 3900
ggccttttcc atgcctgcgc tatacccccc cactttcccg cttatctgtc cgagcggaga 3960
cagtgcgatc ctccgttaag atattcttac gtatgacgta gctatgtatt ttgcagagct 4020
agcgaacgcg ttgaacactt cacagatagt agggattcgg gtaaagggcg tataattggg 4080
gactaacata ggcgtaaact acgatggcac caactcaatc gcagctcgag cgccctgaat 4140
aacgtactca tctcaactca ttctcggcaa tctaccgagc gacttgatta tcaacagctg 4200
tctagcagtt ctaatctttt gccaacatcg taatagcctc caagagattg atgatagcta 4260
tcggcacaga actgagacga cgccgatgga tagcggactt ttggtcaacc acaattcccc 4320
acgggacagg tcctgcggtg tgcatcactt tgaatgtaca agcaacccaa gtgggccgag 4380
cctggactca gctggttcct gtgtgagctc gagacttggg atgacagctc tttaaacata 4440
gagcgggggc gtcgaacggt cgagaaagtc atagtacctc gggtaccaac ttactcaggt 4500
tattgcttga agctgtacta ttttaggggg ggagcgctga aggtctcttc ttctcatgac 4560
tgaactcgca agggtcgtga agtcggttcc ttcaatggtt aaaaaacaaa ggcttactgt 4620
gcacagagga acgcccatct agcggctggc gtcttgaatg ctcggtcccc tttgtcattc 4680
cggattaatc catttccctc attcacgagc ttgcgaagtc tacattggta tatgaatgcg 4740
acctagaaga gggcgcttaa aattggcagt ggttgatgct ctaaactcca tttggtttat 4800
tcgtgcatca ccgcgatagg ctgacaaagg tttaacattg aatagcaagg cacttccggt 4860
ctcaatgaac ggccgggaaa ggtacgcgcg tggtatggga ggatcaaggg gccaatagaa 4920
aggcttctct ctcactcgct aggaggcaaa tgtaaaacaa tggttactac atcgatacat 4980
aaaacatgtc catcggttgc ccaaagtgtt aagtgtctat cacccctagg gccgtttccc 5040
gcatataaac gccaggttgt atccgcattt gatgctacca tggatgagtc tgcgtcgagc 5100
gcgccgcatt tattgcatga gtagggttga ctaagaaccg ttagatgcgt cgctgtacta 5160
atagttgtca acagaccgtc gagattagaa aatggtacca gcattttcgg aggttctcta 5220
actagtatgg attacggtgt tttcactgtg ctgcggctac ccatcgcctg aaatccagct 5280
ggtgtcaagc cattccctct ccgggacgcc gcatgtagta aaacatatac gttgcacggg 5340
ttcactgcgg tccgttctga gtcgaccaag gacacaatcg agctccgatc tgtatcctcg 5400
acaaacttgt acccaacccc cggagcttgc cagctcctcg ggtatcatgg agcctgtggt 5460
tcatcgcgtc cgatatcaaa cttcgtcatg ataaagtccc cccctcggga gtaccagaga 5520
agatgactac tgagttgtgc gatccctgca cttcagctaa ggaagctacc aatatttagt 5580
ttctgagtct cacgtctgac ctcgcgggta gattgccatg cgtagagctt acgagccagc 5640
ggaaagtgtg aggcgctttt aagtatggcg agtaagtgat ccaacgcttc ggatatgact 5700
atatacttag gtttgatctc gtcccgagaa ttttaagcct caacatctat gagttatgag 5760
gttagccaaa aaagcacgtg gtggcgccca ccgactgttc ccaaactgta gctctttgtt 5820
ctgtcaaggc ccgactttca tcgcggccca ttccatgtgc ggaccatacc gtcctaattc 5880
tttggttatg tttccgatgt aggagtgaac ctacttgcct ttgcgtctta ataccaatga 5940
aaaacctatg cactttgtac agggtaccat cgggtttctg aactctcaga tagtggggat 6000
cccgggtaaa gacctatatc tgcggtccaa cttaggcata aacctccatg ctacctagtc 6060
agacccaccc tgcacgaggt aaatatggca cgcgtccgac ctggttcctg gcgttctacg 6120
ctgccacgtg ttcattaact gttgtttggt agcacaaaag tattaccatg gtcctagaaa 6180
ttcggcacag ttagttcgag cctaatgtca caaatgacgc agaacgccaa tgagtgttag 6240
acattaggtg gagttcagtt cggtaacgga gagactctgc ggcatactta attatacatt 6300
tgaaacgcgc ccaagtgacg ctaggcaagt cagagcaggt tcccgtgtta gcttaagggt 6360
aaacatacaa gtcgattgaa gatgggtagg gggcttcaaa tcgtccagca ctctacagta 6420
cctccgagag caagtagggc accctgtagt tcgaagcgga actatttcga ggggcgagcc 6480
cacatcgtct cttctgcgga tgacttaaca cgttagggag gtggagttga ttccatcgat 6540
ggttataaat caaaaaatcg gaacgctgtc tggaggatga atctaacggt gcgtatctcg 6600
atcactcagt cgcttttcgt actgcgcgaa agttcgcacc gctcatacac ttggttccga 6660
agcctgtcct gatatatgaa tccaaactag agcggggctc ttgacgtttg gagttgtaaa 6720
tatctaatat tccaatcggc ttttacgtgc accaccgcag gcggctgacg agggactcac 6780
accgagaaac tagacagttg cacgttggaa gtagcgccgg ctaagaaaga cgcctggtac 6840
agcaggacta tgaaacccgt acaaaggcaa catcctcact tcggtgaatc gaaacgcggc 6900
atcaaggtta ctttttggat acctgaaaca aaacccatcg tagtccttag acttgggaca 6960
ctttcacctc tagggcccat atctggaaat agacgccaag ttcaatccgt actccgacgt 7020
acgatggaac agtgtggatg tgacgagctt catttatacc cttcgcgcgc cggaccgggg 7080
tccgcaaggc gcggcggtgc acaggaaaca ttaaatcaaa gaagtttatc aaccaattag 7140
tacagtggca tgttaagtaa aacagaaaga acgccaagtg gcaacaaatg acgtaattat 7200
ttaagcaaaa agcgtaaacg cttacaaagg ctatttaaat atcagtaaat cgttggaaat 7260
tgggtatgtg ctgccttcat acgcaaaaat ggatgcgaca gaaacgagtt gtatggcctc 7320
cactacgctc gcctgccgcg gaccctaaac gacagtcgtt tgcccaacta cggctacggc 7380
atcgctcaga acttcgggtc ttggcccacc tttctgacgc ctagtcaacg tgcgtcgcct 7440
cagtcttggt ctgtatgacg gtatctgctg atcggtaggg agaccgagaa tctatcgggc 7500
tatgtcacta aaactttcca aacaccccat gtcgatactg aacgaatcga tgcacactcc 7560
cttccttgaa aacgcataaa catacaagtg ggcagatgat gcgtacgccc ttctaataca 7620
tccaacactc tacgccctct tcaagagctg gaagggcacc ctgcacttgg ataagagatt 7680
atctcgtaag gcaagctcgt accgtcattc atgcggaaga gttaacacga ttggaagtag 7740
ggatagtttc gaacctcggt tactagtcct aataagggaa cgctgtctga aggatgagtg 7800
tcaaggacaa aaagaagaaa tatcaattgc aaaaataact ataggtactt ctttgaagaa 7860
accaaacgtg agtttctaac acgactaaat ccatttgatc tttgagaaag tcgaagacga 7920
atggtggcat gtgccatgct agcctgcgga gcactctagt tatgcatatg gtccacagga 7980
cactcgtcgc tttcggattt gccctctatg tgacggtttt taggcacact tatgctcagc 8040
accgtttaaa ccagaccgac actagatcta taaggtccgc catgcagacg agagcacacg 8100
gagatcaccg agcaatctat ctgatcggcg accatttgtg tggtactgga gccgagaggt 8160
aactacgatg ccgctaacaa cctctcggtc gtcgctgacg tttatagtct agtctcatta 8220
taatcgtacg ctattcaggg attgactaat accggaaaac atctcagttg aagtaatgta 8280
tacgacagag accgtgcacc taccaaacct ctttagtcta agttcagact aattggtagt 8340
ttgtctagaa ctcagatttt atcactagag gacgcacgct ctatttttat gatccattga 8400
tgtccctgag gctgcaatat atgcaaccag gcagtcttcg cggtaagtcc tagtgcaatg 8460
gggctttttt tccttagtcc tcgagaagag gagacgtcag tccagatatc tttaatgtgg 8520
taattggaag gactcttggc cctccaccct taggcagtgt atactcttcc ataaacgggc 8580
tattagttat gaggtccgaa gattgaaaaa ggtgagcgaa ctcggccgaa ccggaaagac 8640
ggacttcaaa gcaacctgac cacggttgcg cgtccgtatc aagatcctct taataagccc 8700
ccgttactgt tggttgtaga gcccagaacg ggttggccag atgtgcgact atatcgctta 8760
gtggctcttg ggccacggtg cgttaccttg caggaattga gaccgtccgt taatttccct 8820
tgcatatata ttgcgttttt ttgtcctttt atccgctcac ttagaaaaga gacagatagc 8880
ttcttaccgg tgcgcctccg tacgcagtac gatcgcacgc cccatgagaa cgataggtaa 8940
acctagtgtc ctgtgagcga caaaagctta aatgggaaat acgcggccat aagttggagg 9000
tgggtttata tcgcgtatcc atccaactta actgaaacgc gaagcagtag acagtgttga 9060
tcgagatttg cgaagggaaa cagtaaaagt ccagggtgtc gttaattacg acaaaactaa 9120
agactgtata gttagaagga tcaattgggc tgatttagaa atggtataag ttaaagaaat 9180
ggaaacttat tcgacaaaaa gaaaaactca tgatgtatag atggaaactg ccataatgtc 9240
gattcgagtt atatttttag attttggtaa aatatccaac atgtattaac gaaattttga 9300
agtatagatc aaactattct tcaggtacag catcaagcat tcggtagcat aagccaaaca 9360
agtctttgaa gggttggaca tagcgagttg tgtagaaagt tacgaagact tcaacagaaa 9420
aagagtttaa aaggaccacg tatgccaaat cgacaacaat atagtcgttc tattctgcga 9480
tatgtaagat agagacacat cggcaggtag catagaactt gggtcaatta ttatttaagt 9540
gcggtaacaa acaaacttag ggaatattat tgtgctacag caaatgcctt gaaaagtcga 9600
gaaagactac tatactcgtc aagttcgtaa agacttaaca gtaattgtaa tgcaaatact 9660
tagcgagatt gattccttcc cagtagtcat ctttccttta gatattagaa cagcaatttt 9720
agattttgta catagtggag aaaaggacgt cattttaatg gatgaaccag acgttaacgt 9780
catttacttg gtcgttgatt tcgaagactc agtcatcaaa attgtagctt cgctagctaa 9840
tgtgcttaaa atcatcatag tcaaagtgta cgtggtcgtg gtaataaaca accttcatta 9900
ctgtacaaaa gtgccagttt gttacattat cgaacgctgt atagaggtat catttcacct 9960
atttgacaac taggtgataa accttcggtc gctagacgtt gttgttattg aaaaaatgga 10020
agataatcta tacttaatcc aaaacaaccc agaccaagct cgtatataaa tggaagtcgt 10080
caaaattggt ttcgttcaaa taagttggga ctgatgaatc agttttctga acttcaccgc 10140
tattagcgtc ctagttgtct acataattag tatcattatt gtagtagttt aaatcgctaa 10200
caaccaaaaa atccttgaca tgggtaacga cgttattggg gaaccaatgc tcagtgttgg 10260
tgaaagaatc gttaggtcga actattggta cgttctaata aaagacgaca tagaaattcg 10320
ttacataatc aacgtcacta ctaagggcgt attgcaaatt agttcataaa ttattaacag 10380
tttgcaccta atagttctag tccttaaaaa ggtagaagac gtaggtaatg tcagttgcct 10440
caatgtagtc aggtaaaaag tatatgtgct gatggcaaac ttcatctttg tgagagttga 10500
gcatgtataa caacatcact cagtataacc gcttggttac acaattagta tcatgcctat 10560
agaacgcctt atcattcagg tcgtcgtgat agtgaagggg atcaaagtca aaatctactt 10620
tgtcataact ctttacggta tcccaatgct tggtataagt gcttaagaaa ttgtttaaac 10680
agaaactcaa gtataagcga aaacaagtta cctggaaaaa gaagaagtgc gtataattga 10740
tgaacgagtc gaagtcgaag ttgttcaaca agagagttag gtagtgccgc ttgaaaaagt 10800
aatagtgcaa ataagaaagt aagactgtat cggagacgac tttttaatag tagtaattct 10860
cggtacaact aaaccagtaa tttcagacac tgaaatagag gacttcgtta ggtacgaagc 10920
aagttaacta aatgacaatt aaattgaggg taaatatcac aaagaaatca tggaagattt 10980
cgaccgaata caggaaaatt tagattaaag gtttgtcgtc gttgaaataa gaagaagcga 11040
aacggcattc gtttaacaaa acgtcacata tttaggtata gtagattgcg ttcacaaaga 11100
aatttaaagt cttgtaatta tggtggtcga tttattggta gtatatttgg aaatagcatg 11160
caattttgga atggacgaag aacctgacat ctgagctatt gtaagtttaa tttaccattt 11220
cgtcattgta tatgcggtaa acgtaaattt acacatatga cacgaacttt gagttttatt 11280
agcctgccta attgttggta acaatgtaat ggaaattggc gatgactatg gggaaagagc 11340
aatcaactca ccataaattt gtgaacgcag ttaagtaatt ggcatcgcgc gcctaatcgt 11400
ttacattcgc atggaacaag aagaaagaga cctattcgtg ggagtcaatg gctatgtgga 11460
aaaacatgaa ctgccaaatt cggctaacca accagaaatg gtcatggaaa attcttgcgt 11520
caaagttcgc ggtgacgttt acgaagaagc taaacttgtg cttgtttaga aagttaggtg 11580
cgtcctggtt ttagtaaatt tagaaaacca ttttgttgtt tgcgacagtt aaataaaact 11640
taacgacaaa gaagtgactt gcgtcgtaga ttaactggaa attaaagtgg tatctaaaat 11700
ggggtttgcc gatgcggtct tcaaagtcta aaattcttga agtttgcgtt tggtcgcaaa 11760
aattatggat ttagtcgatt attgcctact aagcagcagt ttagaagttt ttaagatagt 11820
tacgctagaa gaccgggagt atacttagtt caatcttcaa taccttatat tattgtacac 11880
ctaccggtca ccagccaaca atgtgcggac ggcgttgcaa ctttcagggc ctaatctgac 11940
cgttctagat acggcactgt gggcaatacg aggtaatggc agacacccag tgtcgaacaa 12000
cacctgacct aacggtaaga gagtcacata atgcctctgg ccgcgtgccc agggtatatt 12060
tggtcagtat caaatggact gagatgaatc tttacaccga agcggaaacg ggtgcgtgga 12120
ctagccagga gcaaacgaaa aatcctggcc tgcttgatgt ctcgtaatgt tcttagagat 12180
ggacgaaatg tttcacgacc taggaaaagg tcgccctaca aaatagattt gtgttactct 12240
cttcataagg agtccggtgt accgaaagaa caaggcgagc ctaggtagca accgccggct 12300
acgggggtaa ggtatcactc aagaagcaga ctcagtaaca cacggtctag ctgactgtct 12360
atcgcctagg tcatataggg acctttgata tctgcatgtc cagctttaga attcacttta 12420
gcgcgcagat ttgggtcgag ataaaatcac cagtacccaa gaccaggggg gctcggcgcg 12480
ttggctaatc ctggtacatc ttgttatgaa tattcagtag aaaatttgtg ttagaaggac 12540
gagtcaccat gtaccaaaag cgatattaat cggtgggagt attcattgtg gtgaagacgc 12600
tgggtttacg tgggaaaggt gcttgtgtcc caacaggcta ggatataatg ctgaaaccgt 12660
tccccaagcg ttcagggtgg gatttgctac aacttccgag tccaatgtgt ccgtgttcat 12720
gatatatatg ctcaagggcg agaattggac ctagctttcg tgttagtacg tagcatggtg 12780
acacaagcac agtagatcct gcccgcgtat cctatatatt aagttaattc ttatgga 12837
<210> 345
<211> 148957
<212> DNA
<213> Artificial Sequence
<220>
<223> SIRV7
<400> 345
agttatctca tcttaatatt attgtgatat aatatttgca atcgctgctg tctctccaac 60
tttcgccgta agatcattag acaggcaagc tcttgttata ttttacaagg gcatgtctaa 120
ctatccaatc ataagaggga ttcgacagca gaggtactgc ctgaaatatc atcatgttag 180
cgaaattaaa ttatgtacca gtcgtaaaaa cacggttttt tagcagttta ttttgcgtat 240
aggcttacgt tacttacacg atacctggta ttcgtaatga tcttatcaag cgtctgttga 300
aacagtattc cgaggcgctg cgttaaattg ctatgatata gttattttta ttagtcgata 360
aaaagacaat tatagcgatt aagaatgcaa ctaattataa cgaacggcct caaatagtag 420
aaaatatccc tcctccgggc atctcctaaa atgccatata ttcggattat tgaagatggt 480
taccacggca gttttatcta gtctcatagg tctttatttc gaggttattc ttaccgactg 540
tgatgcgtcg tgtcccagct ttgaatgcga tatcaccgga ttgtctgact tggttcacct 600
tttagattcc tcattgggtt atactaactg acacttattc tttaagtaag gactccttat 660
tggcagtggt gaatgagatt tggcattatc cttattattg ataattttac tcctgtcgca 720
tgaattacag tacgagctta ttttaccagg ataccacttg atcttatgga ggatactctt 780
tcaattcttg aattggaccc acagagatga gtgtactaga tgaacgtaca cattatgtgc 840
tcagttgtat aattgtgtgt tttcaagaaa gaaggtatac gtcaatacat tcagtatcga 900
cataaggtat ttggatagtt tcagtgatat agaccaatag atttcagatc tctttacgta 960
tcagtaaata cctttataga gttgattcat attaacacta attacgcttg gaagaatagg 1020
ttttatacgc tctatttcat ctattttggc tataacagtt gtcggaatta aatagttctc 1080
tcccggaact atagttacaa ttatcttaac cttaatttcc gccactgtta ttgtctatac 1140
aagtttatgt cttactaaga taacttgatc caccataaca cgttgcatga acctctccct 1200
ttgcaagttg tctgctataa aaatgcgctg actttctgcc agtggattct aaatctttat 1260
tgtggcgacc gccaagtgaa atatacagtg taaaaccata aagctgaata taactaccac 1320
ttccacttct gccaccaagt agaccatgct aagttaccac cctattttga atgtcactat 1380
caccgtactt accatattgt tagttaagga taccacccca gcaacgtgat tgcagtctat 1440
tattagccca acaagacctc agaatgcgaa gtagcttata gttttcgttt gtccgtggcc 1500
acataaatat aggtttgtgt ctgtttcacg gacctaattt ggctaaacgt aagtgcgaca 1560
gattacgtct attacgaata agctcactgc caatataata caaaccaaga ctactcttga 1620
tactaatgcc acgcccatag tccaaaagat ttctttcttt atttccagaa caagtttaac 1680
aattacctgc tatacgttgt ccacctctat gttgttagct tcgtcccata ccgtttaaat 1740
tatacgactt tgctgcacta ccattatcca tataagtata tgtctcatgt ctggatgaca 1800
gacatccaag tctactacgt cctctatcct atcgaagatt gagttaaata tctgcatgaa 1860
taagccggcg tcgattaaac gtataatgaa gacgaccgtg ttaacccgca agctgtagtc 1920
gcgcatttat gttcaataga tagcttttag ttatattgct atctctactt gttgaccttg 1980
taagttttcg ataagaattg aatggataat cttgcaccaa actatttcga ctcagacttt 2040
aaaatcgatc tctcgactct cttctatctt ttaatagcct tctgtggata tttgaactat 2100
ctatgcttcc aaactaacga cttctccacc tcttaaatcc taattttctc aaacagtgca 2160
tactactgtt tcctctttaa cttccatatc gcatactagc agatacctaa gtagaatagg 2220
gacaatagtt tcttgttgtt gattcttagt tctttaacct cctcagtttc ttacgttacc 2280
gtcttcccaa acgtcgatta tctgttacct atcccggtct tcttcgactt ctcgataatc 2340
taaaactata tcgttatgtt tacttacttc ttcccggtga tttaggtcct catttgggta 2400
aatcccatgg accttattgt cttcgtcttt tcgttcttat atcattgtat aatgttgggt 2460
tcaatgttct agatttcccc ttttaagttc tccattttga ccttcttcct ttacgtccat 2520
tcaaatcttc tcgttctaaa aattctatga gactactttg tcataacagg gattaagtga 2580
acaagtatcc tataacaggt gtaaatacgt ctgctgtact taatcctaga aattctgtac 2640
tgtatctata tcttcgtgaa gttcttctcg caatacttgt gtcaccaatt aacagttaac 2700
gaatacatga cgatgcggaa cacctcgggc caggccgcgc acttcctata tttactttga 2760
gcagtgtagg tgtaataata tagcatgtag cctcatgctt aacttgaacc ggagataaaa 2820
atctatgcac gcgaccttca catttacaag gtttagattt ttaatgctac ccaaaacaaa 2880
gtccataggt ttttcattaa gactacggcg caaagttaag tgatttcact cctacaacag 2940
aaatatgccc aaactatgaa aacaacatgg ttcgtagaaa taatcaatcg taccattgca 3000
atgtctacct tgttgttagt ctatactact attgcctcac cgagttcgaa acttacaccc 3060
cggtgcacca taatctaatt tacgactatt ttaactataa ttgccattat ccttctgata 3120
ttataatgaa aacacaatgg tttattgtca attacttatg cactgttaca tcttgtggtc 3180
ctcggtccag cctgcgtagg atataaatga agcacgtctc atccagattg atctatcgta 3240
cctccaaata cgaattcaac ttggcgtcta tatccagaaa tgagccctag aagtgataga 3300
cttccaaatc tttaaactac catgggatat gtttcacgta tccaaaaagt aattataatt 3360
ctgcgtttcc attcacttaa gtgaggatgt agcctttata ttggtttcat agttttgtta 3420
taccaagcat gtattttacc tagcactatt ttcaacctaa aactgttttg tttctcgatg 3480
tcaaaccctt gtcagctacc tgcggtggtg cacgaaaaaa ccgattagaa tattaaatat 3540
ttacaactcc aaattttaag agccctgctc tagtttaaat tcatatatca gtataggctt 3600
cgcaatttag tgaataagcg gtatgaattt tcgcggagta tgaaaagtga ctaagtaatc 3660
gagatacata ccgttagata gatgcttcag actgcattct gaatttttga tttataacca 3720
tcgaaggaat caatttcatg ttcctaacgt gttaagtcat cagtaaaaaa gaccataagg 3780
gctccccttt tgaaataata ctgtttcacc accattcctt tagtttaatt cttgatgatt 3840
tcttctcaaa ttacgttggt tagcatgtga aagtttatat aatttgctct aacatcctgg 3900
gttaatatgc agaaaatggg cttagggatg atagacactt tacaaattgc acaagcaatc 3960
gaaatgtttt atgtatcgat atagtatgca tttttataga attgccttct agcatgacag 4020
aaacaagcct atctattcgt ttctttatcc tcctatacca cgtgtgtacc tttcccggcc 4080
attcattaag accaccacaa atatgtctgt tgttccagtt tctttcgtgt ctacgtgtct 4140
ccttttgtaa ctgagcgata ccaagagttt aatatgttcc tttgatgtcc ttattctatg 4200
tataaagagt aataatctta agtctggagt ttactcagca accagttgag tctaggcaca 4260
gctttcttgg gttgcttata tattgaaaat aatgtactca acaggatcag tctcataagg 4320
aattgtgatt gaccaaaagt ccgctatgca ttgacgtcgt ctcagtttag tacctataac 4380
tatcatcatt cttttggtgg ctattacaat gttggtaaaa gaataaaact acaacacatc 4440
tgttaataat caactcgctc gattgattgt caagaatgtt tagtgatgag tatgttattt 4500
aaggcactcg agttgtgatt gagttggatc cattgtagtt tacggctata taagtcctca 4560
ataatacgct ctatacgcaa attcctatta tctgtgaaat gtttaacgcg tacgctaact 4620
ctataaaata cttaactata ttatacgtta gaatatctta acggacaatc gcattgtatt 4680
tatttgtata gattaatgaa aaagtaggtg cgaatattgt aggaccagcg atatgttcta 4740
cgagttcgat ttgaacttct ccgttttgtt ttgcgtcttg atttccgatc tttgcgactt 4800
ttctttcgtc ctgacctgct ttgagctttc ctttatacta actggtattc tggcgaaaca 4860
aagctgtagc agaatcatgt catgagtatt aatagtagta agaaaatcac ggataatgtt 4920
acaaccgttt tcttatttag aggtagtgtg aagaactttt acatgaacca gcaaactaac 4980
atctctttca aattactact catacaataa gttccgtgac gacatgacta tcaccaagta 5040
tgtaactacg agttctacta gaatttctct tccttagcgt tcgcatacga ctaccatttt 5100
aaagccttct tctcgtcctg gggaacctct gcctacaaaa agcgtttatt gttaattgtt 5160
taaagataca gtgaaaacga cagtcgttaa aacaaaaatg atatgtacaa tactacatct 5220
aagcagcgca ataacgcaac agcttgaagt atttttcaca gaaaaatcgt acgtccagtt 5280
ctaacacttt catatgtgtt cgtcgtttat gcttttagta tgaaaactag tgtgccggtg 5340
tctggagatc atccttcttg catatgactc caaggacagc catcatggtt tgtaagttca 5400
ttgagactgt tacgcttaac tggacgaaac tcgagaagat atatgattga tcgtaagacc 5460
gctttgattc gacaccatca taacacagta ctcatgatta tcatcatttt tttagtccct 5520
attacaaagc tgccaagtga ataaatctct atcacactct atgaaaatgc acttgatcgt 5580
tttattgtag aaaaaattta ataaacagaa tgttaatgaa ggcactactg tactaataga 5640
gttgggctat atgttaacta caagactata acttattaat aactcggtct atacataatt 5700
tggtatcatg tatgtagtgt tcaagggcta tagcaattct gataaaaatt tattaaggta 5760
acaccttaga ataatatact ggtctatcgc aatacaacca cttctaccgt ataatccgag 5820
agtggccacg ataatcgaag gtatggtcaa ccgttgtaag taattctagg cgataaggaa 5880
tccttttttt ataaattttc tttaggacat tgttcacgta aattatcaag attaattgtt 5940
gtaatgagct cgtttgattt tgaaaatttg tgtcttaaat tcgtctccga ttaatacact 6000
atactatact ttaatcccag atatatcaat attaaactat ttaatttaat ctaatcctca 6060
aaccttctat taaatcgtgt caatcaatat ctgcttccta aatggaagtt tttcgccaaa 6120
aacaataaac agaatttaaa gtcgcttttg tcctcagcaa ttttgttttt tttatacagg 6180
ttataacgta gattcattcc gttaaagcgt tgtccaattg gataaaaaac atctttttaa 6240
tctccaggtc aagtttgtga aagtaaacac gtcgagcaaa tacgtatacc gcacatttga 6300
ccacgcagcc acatacctct ggaaggaaaa acacatacta acctacctga cgctagtgca 6360
aaacattcaa gaaactctga caatgcgaat taacgagcct taaactcttt tatttgctga 6420
taagcattat tgcgaaacta gcttgagctt gtattgtctg gtgtgtacta ttagaagtga 6480
aaaaatcagg gttaatgtct cgtcgcctca tttatataca gatagtcagt gatacctaaa 6540
cgtatactag caaaatgaca tcttaattaa attatttatc ttacatattc ttcctagatg 6600
acatgaatat gttggtccga tgtataattg atgttctgat ataggataat aactgaaaca 6660
catatgtatt ataccaaagt atgtacatca caagttccca atatcgttta gactactatt 6720
tactaatccc attgtggaat cttaatatat gatcggatag ccttgtgttc gtgaaaacgg 6780
catattaggc tcacagcggt gctattacct tccataccag ctagcaacaa cgataatcat 6840
ccgctattgg ataggaaaat agtatttaaa agaaatcttg taacaaatgt tttatatagt 6900
cctaattaac tacattactc gagcgaacta aaacttatga tcacaaaaat aaagctgagc 6960
ctaattatgt gatatgattt aaaatttcgg tctatatagt tataatttga tgaaataaat 7020
tggattagca gtttgctaga tgatttggca cagatagtca tagacgaagg acttactatg 7080
aaatagcggt tttagttgtc aatgttggat ttcagcgaaa gcaggaatcg atgtagctaa 7140
agaaatatgt ccatcattgc atttagataa ggcatcttgc caaaaagaga accaatattt 7200
tgtaaagaaa ctagaggtcc tctttatact ctatgatttg tgcagctctt aaatgcaaac 7260
gacgagtaaa caggtgcgtg ggtgtatgga gaccttcatt tttatgtatg attggatgga 7320
ctacgatcac attttatggg ttctctgcga ctgtcacgct aaattactcg gaaattgaca 7380
atgtaatcga ctacttgtaa taacccactg atcgaactgg agcataacgg gtcacacatc 7440
ataattttca ctattttagt ccgaattatt cagcatcgca gtaaatgtat aacaatcggc 7500
cactgtccat ttacatatca tcgtattcca ttagaattaa tttaatatat agaatgtgta 7560
agtaggatct actgtactta tatgaccatg ctacatatta acatgaaaac tatatccaat 7620
tcttgacctt gtgtatatat aatatgaata cgaacatgtt ggattcaaaa gttatagcaa 7680
atcccatctt aaatgtttag ggaaaggctt tagtattata ttctagccta ttggaacaca 7740
agcacctttc ccatgtaaac ccagtgtctt caccataatg aatactttca tcgatcgtta 7800
ttgcttttag tacatgatga ctcgtccttt taacataaat tttctactga atattcatta 7860
caaaatgtac caggattaac caatgtaatg agcccccttg attttgggta ctggtgattt 7920
tatttcgact cagatttaca cactaaagta aattttaaag ctagacatac aaatattaaa 7980
gctctctatt taacctaaac gataaacaat cagctaaacc gtgtcttact gagtctgctt 8040
cttgaatgat actttaccgc caaagtcaac agttactacc taaagtcgct ttgatctttt 8100
gctacaccga attctttatg aagagagtaa cgtaaatcta ttttgtagaa cgattttttt 8160
ctaggtcatg aaacatttcg ttcatctcta agaaaattat gagacattaa acaggtcaag 8220
aattttcgtt tgctcctcat tagtccacgc acccattttc gtttcgatgt aaaaattcat 8280
attagtctat ctgatgctaa tctaatatac cctagacacg ctgacagagc cattatgtga 8340
gccttttact gttaggttag gtgttgttcg atactgggtg actagcatta cctcgtattg 8400
cccagagtgt ggtatttaaa atggtcaaat taggctctaa aagttgtaac gccatctgca 8460
cattgttggc tggtgaccgg tagatgtata ataatataag gtattcaaaa ttgaattaaa 8520
tatgctttgc gctcatccta catgagataa atatagtgga acgatgcata attctacatt 8580
cgattcaggt tatgaacagg aactcgtatt taaagttttt atcgttcaaa aacctaagtc 8640
ttcaataacg ttttgggtgg gatttgcaaa ccccttacca aaatcgtaat ataggattgg 8700
ataaacttgt cttcgtggta agggtacaat tgggacgctg aagtagtgta acttatgaga 8760
aaggctaatt ataacaaaaa ttaaattcta gtgaggtgga agattgtatt ttaaagatga 8820
ctaataaata ttgttataca tgctcctaat cggttctacg gctcgcgggc accaaaaccc 8880
atgacctcta aaataaagct gagtttagac gcgtgatttc atttaaaatt tcaatctgtt 8940
tgtctattat atccagagat atactgcatc tcctattagt ttatcgattt cgcatacaat 9000
gactcagaca aagaactcac tatggaatcc gagaatcagg tgccaatgat cgttccgatc 9060
aaaacatgaa agctatgtgg cctgacgaat acttctctca ttgtttttag ataaaagatc 9120
ttgctgaaat aggatccagt actttgtaaa gcaagttgag aatcttataa tgttttgaag 9180
atcatcgggt tctaaaaacc aaacgtggac taattaggtg cgtgggtaaa aatctagcta 9240
catttctaag tagtttcaga taaattatga taagtttata tgggatgcgt acgccagtct 9300
gcataatact ttgagagaat gacaatccaa tctagatcaa gctatgaatt acaaacggtt 9360
atgaagtaaa acgggtgtta cagcttaaat ttagccagaa taatttagga gtttcaacat 9420
tgccgtagag gtgtaacaac tcaccagtgg ccatccacat attaatatat tccataactt 9480
ttaactaatt ttatttgtaa cgcgggcaaa atatattttg tttaagtctg cttgctacga 9540
tcttagacat aagcttggtt caatactcgc gcttaaagaa aaatttcaaa aacagcaagt 9600
ttttggactc tcaaattgtt acaaaatgca ccctgtacgt taggggaatg gttactactt 9660
tatatccatt cttgtttaga cagaagcacg attcccatgt taatcctcca acttcattac 9720
attgaatata cgttcccttt aattttctat ttgatttaag gtcattccat catctaacac 9780
taaatttcta ctgattattt ataacaatat gtaggaggat taggcaagat gcgaaatgct 9840
ggttgttttt ggttctggac attttatctc gaattaaatc tgcgcattaa tatgaattct 9900
atagattgac aagcagaaaa cataggtctc tttaagacaa tgggaataat taaataccta 9960
gagcataaat tactgagtaa atatcttgac tcatatcata gattcctagc ccccggttgc 10020
taggaaggtt agtcttgtag tttccataga ccagactgct aaagaagaga gttactgata 10080
tctttttttt agggcgacgt aatcctagat gatgattcat atggaccaac acttagaata 10140
ttacaaatct tctagttacc taatattttt gatttgcacc tgggaaatca ttgcattcga 10200
ttttagatcg gtgtaaagat tgatcaaact ccatttaatt ttatccaaat ttaccatatg 10260
catgggataa cacgtattat gaaattcact tttcgttagg ttacaactag ttcgagactt 10320
attgtttgct aatactacat tatcctcaca ttagcgaatg taattggctc tctaaaaatc 10380
ctcatagttg taatgggaag ccgagattat tgagtgatca ccagtagctg tactatttta 10440
taagctatta aaaattgatt aaaataaaca taccgcctgt aatatataaa tcatagtcag 10500
acgaacattg ctacaatctg tattcgtacc aagttatgag cgcgtatttc ttatttaagt 10560
ttttgtcgct cacaaaacac tgggtttacc aatcattcac atgggacatg cgatcgtact 10620
gcctatgatg atatattggt aagaagttat ctgtctttct tctaagagag caattaaaag 10680
gttaaagaaa tgcaatatat atgcaaggga aattaatgga taatcttaat tcctgtaagg 10740
tagcacattg tgacttaaaa atgactaaat aatattgttg tacatctagc taatccgttc 10800
tgggctttac gaccaacagt aacgaagacc tattaaaaag accttgatat ggacgcgcaa 10860
ctatagttaa gttacctaga tgtccgtctt ttctattcag ccaaattctc ttaccttttt 10920
caatctttgg atctcataat taatagctcg tttatagaag agtatatact atctaagggt 10980
ggagggccaa ggatccttcc aatcacaaca tcaaagatat ctggactgac gttttctcct 11040
ctcaaggact atagaaaaaa aatcccattg cattaggatc taccacaaag attacctggt 11100
tgtaaatttt gcaatgttaa gaacatcaat ggatcataaa aataaaacgt gcatccttta 11160
gtaacaaaat ctaagatcta gacaaatttc caactagtct gaacttagat taaagaggtt 11220
taataggtac acgaactctg tcgtatatat tactttaagt gaaatgtttt ccagtgttga 11280
tcaatctctg aataacaaac gattataatg aaattagagt gtaaacgtta acaacgaccg 11340
agagattttt agcagcatca tagttacctc tcggctctag tatctcacaa atggtcatcg 11400
atttgataaa ttgctcgata atttctatgt actttcattt gtatggcgga ctttataaat 11460
ttagtatcag tctggtttaa acgatgttga gcataagtgt gcttgaaaac tgccacataa 11520
agggtaaatt cgaaaacaac gagtgttttg tgaaccatat gcataattag agtaccctgt 11580
acgctagcat gacacatgcc tccacaaagc tattcttcaa tacagtataa atagattcat 11640
tcgtctattt ttctatttat atgcgttata tttacgttgt ctttaattac ctgctagaat 11700
taaagacatt ccattgtgta ggactgagtt ttcagtaatt cattatatta acttgaagac 11760
caattaggca agacccgaca agttggttgt gaatgcctcc gaataattct tctaaaacta 11820
tgcctgggtg ttgacagcaa tccattgaaa cttcaggcag aaaagcttag ccggtttaag 11880
tgaatggaaa aacttagaag cgttctgtat tgattatcga ggaaatattt tctcatttgt 11940
gacagatttc cacctcccgg ttcttaggaa ggttaaaggt gtaattacta ttgacgtgac 12000
tgcagaggag aagagatctt gttttcattt tttaacggta acgtgatcct gaatggcgtt 12060
tataatggag caatatattt aacgtcggaa ttcttgtagt tatctagtat ttttattttg 12120
tatataggag ataataattt tacattcaag atttgtttca tgcttaatca gtcttgaatg 12180
taatttctct aaatcatcca tgtgccagag acagcatatt taatgaaata aactttacaa 12240
aaggtcataa ttagttaggg agttatcgta tgttaatatt actctgatct gatatttgca 12300
atcgctgctg tctctccaat attcgccgta atatcaatag agaggcgaga tcatactgtg 12360
ttttccaacg gcaagtctat ctaaccagtt attagaggaa cttgatagca gacatacacc 12420
atttctattt caatgctatt tgcttatagc tttgcctaac cttcttgttt ttgttatatg 12480
actactggtc aattcactaa acaggttatt aggactctaa tttcgttcat aacttgttcg 12540
tttagttctt cgcgttcttc gaaatcctat caatttcatg ttcctaacgt gttaagtcat 12600
ccgcaaaaaa gacgataaga gcttgccttt cgaaataatt ctgtttcaaa ctataggctg 12660
ccctacttgg tcttcaagat actatagagt cttcgatgat ttaaagcccc caacccatgt 12720
tcaatcaact tgtatgttta tccttaaact aacataggaa ccagctaaga tttgtttagt 12780
atcatttggg cacgtttcat atatataata aagtatgccg caaagtttct ccgttaccga 12840
actgtactcg acctaaagtc taatactcat tggtgttcta tcacatttgt gacattaggt 12900
ataaattaac tctggagaat ttctacgact ataataaaag ttttgtgcta ccaaataact 12960
gttaataaac atgtcactat gtagaacgcc aagaaccagc tgggatgaat gctttattta 13020
cttcgtgcaa agtaggtcta agtagatagc atcgaggttt atgcttaagt tgaaccgcaa 13080
atataggtct tttgtcggga tctccactat ctgtaaattg tgaaacctgt tggtacccta 13140
tacaaagtgc atagctatat cattaataat aagacgtaaa cgaaagttta ttcactccta 13200
cttcggaaag ataaccaaag aattaggaga atatggtgcg cacatagaaa ggatcgggaa 13260
ataactttga ccttcacaga acaataagtt acaatttggg aacagtcgga gaacgccact 13320
acgtgctttt ttggcttacc ttatatttta taattgatga ggattaaaat tcacgggaga 13380
agatctaact taagtatata gttatatctg aagcgtttga tcacttactc cctttactta 13440
aataggcctt attgttttcc ctgactcata agttctatgt ttggcaatct atctacaagg 13500
tcagacgtat cacttaaaaa ctaaaaattg gtaacttcct tagttaaagt gctaggaatg 13560
ctcaattcag tagtcttttt ctctggaaat cgcgaggggg gaactttatc atgtcaaagt 13620
ttgttattgg actcattcaa ccataggctc tatgatattt aaaaagctag taaactacgg 13680
gggtaggata caaatttctt gataatagaa atcggaattc gaatgtgtcc ttggtcgact 13740
cagatctaat ccaagtgaac ccgacgaatg tatatatttt attacatatg gcgtcttaaa 13800
cagggaatcg cttaacatca actggttttc agataatgag taaccgcaac atagtgaaaa 13860
cacagttatc catactagtt agagaacctt taataatgct gctaccattt tctaatcttg 13920
atgatttgtt gacaattatt agtacagcga ggcatctaac ggttcttagt caactctact 13980
tatgcaataa atgttgcatg tttgatgctg actcaaccat ggtagcatca aatacggata 14040
caattaggcg ttaatatgca gaaaacgggc ctaggggtga tagacacttt acaatttgga 14100
caagcaatgg aaatgtttta tgtatcgata tagtatgcat ttttatacaa ttgctttcta 14160
gcaagtgaga aagaagccta tctattcgtt tctttatcct cctataccac gtgtgtatct 14220
ttcccggcca ttcattaaga ccggaagtat cttgttatac aatattaaac ctttaacagc 14280
ctatcgcgct gatacacgaa ttaaccaaat gaaatttaaa atattaacta ctgttatttt 14340
taagtggcct cttcaagatt gcattcatat atcaatattg acttggtaag gttctaaatg 14400
agggaattga attaatctgg ataaacaaaa gggactgagg attcaaaata ccaaccgtta 14460
aatagatgtt cctctgtgca tagtaaattt ttgtttttta acctttgaag gaatcgacaa 14520
cacgaccctt gcgagtttag tcatgagaag aagagatctt caaccttccc cccttaaaat 14580
agtacagctt caaacaatat cctcagtaag ttggtatgtg tggtactaag attttcacga 14640
ccatttgatg cccttattct atgtataaag agttattatc ttaagtctga agtttactca 14700
gcaaccagtt gagtctaggc ttagctttct tgggttgctt atatattgaa aataatgtac 14760
acaacagaat cagtctcata aggaattgta attgaccaaa agtctgctat acattgacgt 14820
tgtctcagtt tagtatctat aactatcatc aatctcttgg taactattac aatgttggta 14880
aaagattaaa actacaatac atctgttaat aatcaactcg ctcgatagat tgtcaagaat 14940
gtatagagat gagtatgtta tttaaggcgt tcgagctgtg attgagttgg atccattgta 15000
gtttatgcct atataagtcc ccaataatac gttttttacc cgaatcccta ttatctgtga 15060
aatgtttaac gcgtacgcta gctctataaa atacttagct atattatacg taagaatatc 15120
ttaacggaca atcgcattgt atttgtttgc atagataaat gaaaaaatag gtgcgaataa 15180
tgcaggcatg gtaaaggccg gtaagtaatt ctagccttca tggaacgtta tgttttaatt 15240
tgaaaattat gggatagcgc gtctaaatcg ttaattaaat tagttgaaat cacctagtta 15300
gtatctgtaa aaattcacca aaaaagttcc atcgtaaatt tataattact actgaatgat 15360
tccaaaattt actctcttaa gttaattaga ccaatctgtt tccctaggct tctataaaat 15420
accgttggta attttcccgc atggagacag atgttattcg gaaataaaaa tttagaaact 15480
tctttagcac ttctgctgac aacagttatg tttatactat tcttctcttg atgtagaaac 15540
gaggcgttat tatcatgtcg aagtttatta taagtgtcat tttaccatac agaccatgat 15600
tctgaaagta ctgacaagct gcaaatatga aattcatatt tctcatcact agggtacaga 15660
cctctaataa gatgtaggtt aactgagatt cgtgtcggaa gaacccaacg aacatataac 15720
tttcactata tgagttgacc tgctctgagc tttccttaat actaactggt attctggcga 15780
aacatagctg cagcagaatc aagtcatgag tattaatagt agtaagaaaa tcacggataa 15840
tgttacaacc attttcttat tttgaggtag tgtgaagaac ttttacttga accagcaaac 15900
taacaactct ttcaaatcac tactcataca ataaattccg tgagcacatg actatctcaa 15960
cctggataac aattaatgct catatattga gaagttatta agcgagatat gcgtttaagg 16020
ataatagaca ctttacaaat tgcggatacc attgagatat tttataaata gatgcaatat 16080
ggaatcttat agaattgcct gttagcgtta tatagatgaa catgactaat taccctttca 16140
tccacgctat tagcttccat accatttgcg gccattcatt aagatccgtt gttccttaca 16200
ataaaaaaat taataaaaaa ttccctaaca tgcagattta gtagttattt taaacaactt 16260
tagtggaaca aactaaaaca tttttaaaca gaattttgat agtggcaatt aattactaat 16320
gatgtgatat taaggtctta aatgtaagaa ttcgataaat ttgattagac aaagggatcc 16380
gaagatattt tagcgcagtc actaataggg ggtacctctg cctacaaaaa gcgtttatta 16440
ttaaatgttt aaagatacag tgaagacgac agtcgttaaa acaaatatga tatgaacaat 16500
actacatcta agcagcgcaa taatactaca gcttgaagta tttttcacag aaaaatggta 16560
cgtctagttc taacactttc atatctgttc gtcgtttatg cttttagtat aaaaactagt 16620
gttccggtgt ctggagatca tcctacttgc aattgactcc aagcacagcc atcatggttt 16680
gtaagtacat tgagactgtt acgcttaact ggacgaaact cgagaagata tatgattgac 16740
cgtaagaccg ctttgtttcg acaccatcat aatacagtac tcataattat catcattttt 16800
ttagtcccta ttacaaagct gccaaatgaa taaatctcca tcacactcta tgaaaatgca 16860
cttgatcgtt taattgtaga gaaaatttaa taaagagaat gttattcaag gcactactgt 16920
actaatagag ttgggctata tgttaactac aagaatataa ctttttaata attcggtcta 16980
tacataattt cgtatcatct gtgtagtgtt caaggcctat agcaattctg ttaaatattt 17040
atcaaggtaa caccttagaa tattatattg gactatcgca atacaaccac ttctaccgat 17100
taatgcgaga gtggccgcga taatcgaagg tatggttaac cgtagtaagt aattctaggc 17160
aataaggaat gctttttttt taaatattct ttaggacatt gtacacctaa attatcaaga 17220
ataattgttg taatgacctc gtttgatttt gaaaatttgt gtcttaaaac cgtctccgat 17280
aattatacta tactacactt taatcccaga tatatcatta ttaaactatt taatttaatc 17340
tattcctcaa accttctatt aaatcgtgtc aatcaatatc cgccttctaa acggaagttt 17400
ttcgctaata acaataaaca gaattcaaag tcgcttttgt cgtcagcaat tttgttttta 17460
ttatacaggt tataatgtag attcgttccg ttaaagcgtt gtccaattcg ataaaaaaca 17520
tctttttaat ttccaggtca agtttgtgaa agtaaacacg tcgagcaaat acgtatacca 17580
cacatttgat cacgcagcca catacctctg gaaggaagaa cgcatactaa cgtacctgac 17640
gctagtgcaa aacattcaag taactctgac aatgcgaatt gacgagcttt aagctctttt 17700
atttgctgac aagcattgtt gcgaaactag cttgtgctag tattgtctcg tgtgtactat 17760
tagaagtgaa aaaatcaggg ataatgtttc gtcggttcac ttatatacag atagtgagtg 17820
atacttaaac gtatactagc aaaatgacat cttaattaaa ttatttatct tacatatact 17880
tcctagatga catgaatatg ttggtccgat gtacaattga tgttctgata taggataata 17940
actgaatcac atatgtatta taccaaagta tatacatcac aagttcccga tatcgtttag 18000
actactattt actaatccca ttgtggaatc ttattatatg atcggatagc cttgtgttcg 18060
tgaagacggc atattaggct cacaccggtg ctattacctt ccataccagc tggcaacaac 18120
gattatcatc cgctattgga taggaaaaaa gtatttaaaa gaaatcttgt aacaaatgta 18180
ttatatagtc ctaattaact acattactcg agcgaactaa aacttttgaa cacaaaaatt 18240
aagcagaggc taattatgtg atatgattta aaatttcggt ctatatagtt ataatttgat 18300
gaattaaatt ggattagcag tttgctagat aatttggcac agttagttat agacgaagga 18360
tttactatga aaaagcggtt ttagttatca atcttagatt tcagcgaaag caggaatcga 18420
tgtaactaaa gaaatatgtc catcattgca tctaagtaag gcattttgcc aaaaagtgaa 18480
cctatatttt gtaaagaaac tagaggtcct ctttatactc tatgatttgt gcagctcttt 18540
tatgcatatg acgagtaaac aggtgcgtgg gtgtatggag accttccttt ttatgtatga 18600
ttggatggac tgcgatcaca ttttataggt tctctgggac tgtcacgcta aattgctcgg 18660
aaattgagaa agtaatcgac tatttgtaat aacgcattga tcgaactcga gcataacggg 18720
tcacacatca taatcttcac ttttttagtc ccaattattc agcaccgcag taaatgtata 18780
acaatcggcc actgtccatt tacatatgat cgtattgctt tagaattaat ttaataaata 18840
gaatgtgtaa gaaggatcta ctgtacttat acgaccacgc tacatattaa cttgaagact 18900
atatcctatt cttgaccttg tgtatacata atatgaatac gtacatgtag gattcaaaag 18960
ttatagcaaa tctcatgtta aatgtttagg gaaaggcctt agtattatat tctagcctat 19020
cggaacacaa gcacctttcc catgtaaacc cagtgtcatc accataatga atagtttgat 19080
cgatcgttat tgctattagt acatgatgac tcgtcctttt aacataaatt ttctactgaa 19140
tattgattac aaaatgtatc aggattaact aatgtaatga gcccccttga ttttgggtac 19200
tggtgatttt atttcgactc agattaacac actaaactaa attttaaagc tagatatata 19260
aatattaaag ctctctattt aacctaatcg ataaacaatc aactaaaccg tgtcttactg 19320
tgtctgcttc ttgaatgata ctttatcgcc aaagtcaaca gttactacct aaagtcgctt 19380
tgatcctttg ctacaccgaa ttctttatgg agagagtaac gtaaatctat tttgtagaac 19440
gatttttctc ttggtcatga aacatttcat tgatctctaa gagaaatatg agacactaaa 19500
caggtcaaga attttcgttt gctcctcatt agtccacgca cccattttcg tttggaagta 19560
aaaattcata ttagtctacc tgatgctaat gtaaaatacc ctagagacgc tgacagtgcc 19620
attatgtgag ccttttactg ttaggttagg tgttgatcaa tattgggtga ctagctttac 19680
ctcgtattgc ccagagtgta gtatttaaaa tgattaaatt aggcttaaaa agttgtaacg 19740
ccatctgcac attgttggct ggtgactggt agatgtataa taatataagg tattcaaaat 19800
tgaattatat atcttttgcg ttcatcctag atgacatgaa tatagtggaa cgatgtataa 19860
ttctacattc gatttaggtt atgaacagga actcgtattt aaagttttta tccttgtaaa 19920
acctaagtct tcaatatcgt ttagggtggg atttgcaaac cccttaccaa aatcataata 19980
taggatcgga taatcttgtc ttcgtggtaa gggtacattt gggacgctga agtagtgtaa 20040
cttatgaaag aagctaatta taacaaaaat tatatactag tgagctggaa gattgtattt 20100
aaaagatgac taataaatat tgttatacat gctcctaatt ggttccatga ctcgcgggca 20160
ccaaaaccca tgacctctaa aataaagctg agtttaaacg cgtgatttca tttaaaattt 20220
caatctgtat gtctattata tccagagata tactgcattt cctattagtt tatcgatttc 20280
gcatacaatg actcagacga agaactcact atggaatcgg ggaatcagat gccaatgatc 20340
gttttgatca aaacaagaaa gctatgtggc ttaacgaata cttctctcat tgtatttaga 20400
taaaagatct tgctgaaata agatccagta ctttgtaaag caagtagaga ttcttataat 20460
gttctgtagt tcatcgggtt ctaaaaagca aacgaggact aattaggtgc gtgggtaaaa 20520
acctagctac atttctaagt aaaatcagat aaactatgat aagtttatat gggatccgta 20580
cgccagtctg cataatactc tgagagaatg acaatccaat ccagaacaag ctatgagtta 20640
cagacggtta tggagtataa cgggtgtcac agcttaaatt tagccagtat aatccaggag 20700
tttcaacatt gccgtagagg tgtaacaacc caccactggc catccacata ttattatatt 20760
ccataacttt taacttaatt tatatgtaac gcgggcaaaa tgtattttat ttaagtcagc 20820
ttgctacgtt cttagatgta agcttggttc aatactcgcg cttgaggata aatttcaaaa 20880
atagcaagtt tttggactct caaattgtta caaaatgcac cctgtacgtt tggggaatgg 20940
ttacaacttt atatccttac ttgtttagac agaagcacga ttcccatgtt aatcctccga 21000
cttcattaca ttgaatatac gttccgttta atattgtttt taatttaagg tcattccatc 21060
ttctaacact aaatttctac tgattattta taacaatatg taggaggatt agccaagatg 21120
ccaaatgctc gtagttttag gttctggaga ttttatctcg attcaaatct gcgcactaat 21180
atgaattcta tagtttgaca agcagataac ataggtctct ataagacata gagaataatt 21240
aaatacctag agcatatgtt actgagtaaa tatcttgact catatcttag attcctagcc 21300
cacggttact aggaaggcta gtcttgtact ttcgatacac cagactgcta atgaagagag 21360
ttacagaaat ctttttttta gggcgacgtt atcctaggtc atgattcata tcgtccaaca 21420
cttagaatat tacaaatctt ctagttacct aaaatttttg atttgcacct gggtaatctt 21480
tgcattcgat tttagatcgg tgtaaagatt gatcaaactc tatttaatat tatccaaata 21540
taccatacgc atgggataac acgtattatg aaattctctt ttcgttaggt tacaactagt 21600
tcgaaactta ttgtttgcta atactacatt atcctcacaa taccgaatat aattggctct 21660
ttaaaaatcc tcatagttgt aacgggaagc cgagattatt gagtgatcac cagtagctgt 21720
actattatat aagctattaa aaattgatta aaataaacat accgcccgta ttatataaat 21780
catactcaga cgaacattgc tacaatctgt attcgtacca agttatgagc gcgtatttct 21840
tattaaagtt tttgtcgctc acaaaccaca gggtttatca atcatttacg tgggacatgc 21900
gatcgtattg ccaatgatga aatataggta agaagttatc tgtctttctt ctaagagagc 21960
aattaaaagg ttgaagaaat gcaatatata tgcaagggaa attaatggat aatcttaatt 22020
cctgtaaggt agtagattgt gatttaaaga tgactaaata atattgttgt acatctacct 22080
aatccgttct gggctttacg accaacagta accaagacct ataaaaaaga gcttgatatg 22140
gacgcgcaat tatacttaag atacctagat gttcgtcttt tctattcagc caaattctgt 22200
tacccttttc aatctatgga tctcataatt aataactcat ttatagaaga gtatatacta 22260
tctaaggatg gggggccaac gatccttcca atcagaacat caaagatatc tggactgacg 22320
ttttctcctc tcaaagacta tagaaaaaaa atcccgctgc attaggatct accactaagt 22380
ttacctggtt gtaaatcttg caatgttaag aagatcaatg gatcataaaa ataaaacgtg 22440
gaccctttag taacgaaatc taagatctag acatatttct aactagtctg aacttagatt 22500
aaacaggttt aataggtaca cgaactctgt cgtatataat actttaagtg aaatgttttc 22560
cagtgttgat caatctctga ataacaaacg attataatga aattggagtg taatcgctaa 22620
caacgaccga gagattttta gcagtatcat agttacccct cggctctaat aactcactaa 22680
tggtcatcga tttgataaat tgttcgataa tttctatcta gtttcatttg tatggcggac 22740
tttataaatt tagtatcagt ctggttataa cgatgttgag cataagcgtg gttgaaaact 22800
ggcgcataaa gggtaaattc gaaaacaacg agtgttttgt gaaccatatg gataattaga 22860
gtaccctgta cgctagcatg acacatgcct ccataaagcc attcttcaat acagtaaaaa 22920
tagattcatt cgtctatttt tctatttttt tacgttatat ttacgttccc tttaattacc 22980
tgctagaatt aaggacattc cattgtgtaa gactgagttt ttagtaattt attatattaa 23040
cttgaagacc aattaggcaa gacccgaaaa gttggttgtc aatgcctctg aataattttt 23100
ctaaaactat gcctgggcgt tgatagcaat ccattgaaac ttcaggcaga aaagcttagt 23160
cggtttaagt gaatggaaaa acttagaagc gttcagtatt gattatcgag caaatatctt 23220
ctcatatgtg atagattccc acctcccggt tcttaggaag gttaaagatg taatttctat 23280
agacgtgact gcaaaagaga agagttcctg ttttcatttt ttaacggtaa cgtgatccta 23340
aatggcgttt ttaatggagc aacatatata acgtcggaat tcttgtagtt atctagtatt 23400
tttattttgt acataggaga tgataatttt acattcaaga tttgtttcat ggttaatcag 23460
acttgaatgt aatttctcta aatcatccat gtgctagaga cagcatattt aatgaaatag 23520
actttacaaa aggtcataat tagttaggga cttatcgtat gttaatatta ctctgatctg 23580
atatttgcaa tcgttgctgt ctctctaata ttcgtcgtag tatcaatgga gaggcgagat 23640
catagtgtgt ttaccagcgg caagtctatc taaccagtta ttagaggtac ttgatagcag 23700
acataccgcc tgaaatattt agatcatagt cagattaaat ttactacaac tcgtaatcac 23760
acgaattttt ggcagtgtat ttcgcatata agcttttgtt gctcacagga cacttggtat 23820
acgtaataat ctcatgagac atctgatcat actgtgtacc gaggtgtttc gataaatagc 23880
tatgttatat ttatctatat aagccgataa aaagacaaat ataggcatta aaaatgcaac 23940
aaaaattaat gaacggtctc aattactgaa aggtatcact ccttgaccca aaactcaaaa 24000
agtgatatat tcgaactact gatgaaaccc atcagggctg ttcaatcaag acttacggga 24060
gcttattatg aggattttgt tacggaccga caaccgtcgt cacgtaactt tgaagtccgt 24120
cttttcggat cgaccgaatt ggttcacctt tttgaatctt cgcaagataa tactaatagc 24180
tgctttatat aagagtaaac actgtctata ggtggaggcc tatgagtctt tccaatatcc 24240
ttattaatga taattccact catgtcacct ctactatagt acaaatgtat tatactgcca 24300
ttgcactaga acttacggca aatactgtct cattacataa attgcagcct caaggacatc 24360
aatagatgat aaatataaag cttatgtcct caattgtaaa attgtaagtt cttaacaaag 24420
tacgtattag tcagaactta cattaatgag attaagtact tacacagttt ctgtcatata 24480
aattagttca tttcaaatct ttttccgtat tagtcaatgc ctcaatagga tagaattata 24540
ataagactat attataaacg ttagcgacga cagagaggtt gtaagcggca ttatagttat 24600
ctctccgttc gagaacgata taaaaagttc ccgtacagat tgataggtta gtattctccc 24660
tgagctatcg tctgcatgac ggactttata gtagtacaat cactttaatt taattcatgg 24720
tcagcatttc tgtgctaaaa aatcgtcaaa taaagcgtat attcgaatac aatgaatgtg 24780
ctatgaacca taagcattac tagagtactc cgcagacaac tatgtcataa ggctccgcga 24840
cgcaatttaa cgatactata tcaataaaaa taatcagcta tttttctgtt tatatcgcta 24900
atttttacgt tgtttaatat tgcttgccag agtttatcat cttttatagg gaggaggccg 24960
gtagaggatt ttacggtata taagcctaat gactactacg agtagtcccg tcaaaataga 25020
tcagagtatc cacaaataaa actccaataa caatggctga ctcttggcag cacagcatcg 25080
aaacttgagg cacaaaggcc taacagactg aaccaagtgg aaaaactaag aagcatccta 25140
atatgattaa ctgtgaataa gattttcatt tgtgagggat atccatcacc agttactcaa 25200
aatcgtaata ggaataataa ctattaaaat gagaacagtg tacataatgt catgcttgaa 25260
taatatggtg gtatggtgat ctagaatacc tcttatgaga gagttatgta tttaacctgg 25320
gtgtctctgt tcatatctac tatttgtatc tctaatacag gagttaacat attaacactc 25380
aagaattgtt tcttccatat acagttatgt aagtgattac tgtaatccat aaacctgtca 25440
aagtcactat atctggttaa gtaaagtcta gagaaatgca taatcaatta cggagttatc 25500
tcaacttagt ataattgtga tataatgttt gcagtggctg ctgtctctcc aactttcgcc 25560
gtgagatgat taaacaagta gactcttgtt atatattaca aggtcatgtc taactaccct 25620
atcacaagag cgatccgaca ggtgaggtat tagcaggaat atcatcatgt cagcgtaatt 25680
aaattatgca ccagtcgtaa aatcacggtt tattagcagt ttaacatgcg tatagtctaa 25740
ccctacatac acgatacctg aaaatcgtaa tgatcttagt aagggattgt taaaacggta 25800
ttccgaggcg gtgcattaat ttgctatggt atggttattc ttattacacg gtttagaaac 25860
aattatagtg gctaagaatg caactagtta ttacgaacgg ccacgaatag tagaaaattt 25920
ccttcctgcg ggcttctcct gaaatgccat ttatacgggt tattgaagcc ggttactacg 25980
acagatttat tcaacctcaa aggtctatat tcccagctta ttcttagccg atatgttgcg 26040
tcgtgtccca gctttgaatg cgttaacacc ggattgtctg acttagttca gcttttggat 26100
acctcatcgg gttatactaa ctgacactta ttctttaaat aaggatccct tattgggagt 26160
ggtaagtgag atttgggatt atccttattt ctaatgatct tacccctttc gcatgaataa 26220
cagtacgagc ttattttacg aggatatcac ttgatcaagt ggaggatact cttccaattc 26280
ttgaatagga cctagagagt tgaatgtatt agatggacgt acgcattatg tgctcagttg 26340
tataattgtg tgttttcaag gaaggaagta tgcgtcaatt cgttcagtat cgacataagg 26400
tatttggaaa gttttagtga catagaccaa tagattttag atctctttac ccatcagtaa 26460
ataccattat agagtcaatt caaatttacg ctatttaaca cacaacgccg aggataaaag 26520
ggctgaaatt gacagtctac tattttgttc atgtgtgaac aattaacaat attcgaatac 26580
acgttgatgc gatagtgctc tggctaggct gtccacttcg tatattttct ttgagtagtg 26640
cagacgtatt aatataatat gtagccagga tcttagcatg aaacgatgat taaaatgtac 26700
gcataccacg ttgggatgta tgtgctatag acttttagta ttacctgaaa catagtccat 26760
cgattttgcc ataagacttc ggcacgaaat taagtgattt cacacctaca agagaaatgt 26820
gccgaatcta tgataatatc accgttcgtt gtattaatca ataatggtag cggctgcata 26880
ttatcaaatg aaggagcgac acccggggag gagtttacgg tggatatccc gtacaacttc 26940
ggctaatcat gttatctaaa taagttgggg tttgcagtta tgagggcgaa atcagattcg 27000
actatacagc gcagttcaga gccctaactc acgtaatcgt gaccttacag agcgagtcaa 27060
gttgataacc tatcgagtag ctcaatatga gtgagtgtga ataagaaatt tattgcaagg 27120
caataatcct aatcattgac agcaaacttt gataagaata aagattagta caattcagaa 27180
agcgtactta ctgtcatact cgaatgaaat gctttattaa agaaaaagtt gacgtcctat 27240
gagaagatta agaacttctc ctgcatctca caacttacat aatcttcggg catgggtaat 27300
agataggtga acatataaat acagaaaagt ttctaccttc atacgtagtt aagcaagtca 27360
tagctatatc ccataaacct ttcataatca ctgtatcggg ttatctaaga actaatggta 27420
tggctagtca tttatggtaa tttgtcagtt aagtcaagat gcggtaaatt gtgtattgcg 27480
gctcctatta tcccgactta aactgtctga tgttataaca aatacacagt agttaattgt 27540
tatttgctta tgtactgcta cgctttgtgg agaccggtcc ggcgcgtgaa gcatataaat 27600
gaaactcatc acatccacat aattatatcg tacatcggtg taggaatcga acttggcttc 27660
taattttaca tgcgtgcgct gcaagtgtaa atataccaaa tctaaaaatc acgatgggct 27720
ttgtttcagg tatctaaaag gaaattctga tgccgcgctt caattcacta aagtgtggat 27780
gttctcttta tacgggtttg atacttttat tgtagcaagc atctttatta gttaatacta 27840
tccccaacgt ataatagttt acttcctcgg tgtgggcccc tcgtcaagtg cctgctatag 27900
agcatgttga agccgattag tataatagat tttttcaact ccaaacgtca acagtcccgc 27960
tttagtttaa gttcatatat cgggacaagt ctcggaatta agtgcataag cgctgggatc 28020
tttcgcgcag ttcgaataat gagtaactga tcgagttaca caccgtcaga cttattcttc 28080
agataacgtt ccgttattac gattaataac tatcgtttga aactattcca tcttcttaac 28140
gtgttaagtc tttcgcaaaa aagacggtat gagcttacct tacgaaataa tttcttttcg 28200
aactacaggg tgctctactt gctcttgaag aaatcgtaga gtgttggatg aattaaaagc 28260
ccctacccat tttctatcga cttgtatgtt tatccttatt ctaacatgga agtttgcatt 28320
gatttgttta gtatcaatta ggcgtgtttc aaatgtatta ataagaatgc cgtatagatt 28380
ctccattacc gaactgaaca ctacttagta ttaaacagtc attgctgttc tacgccattt 28440
aagacattac gctcaaaata actgagctga atttcagaga ctataatatt atttatgtgt 28500
caccaattaa cagttaacga atacgtgacg atgtggaaca ccaggagcca ggtcggacgc 28560
atcctatatt tactttgtgc agagtaggtc taacaaaata gcatgtaggt ttatgcttaa 28620
gttgaaccgc agataaaggt ctatactcgg gatcttcact atctgaaggt ttagattttt 28680
aatggtaccc taaacaaagt gcataggttt ttcattaaaa ttatggcgca aagctaagtg 28740
aattcactcc tacaacagaa atatgaccaa agtatcaaaa caacatggtt cgtagaaaaa 28800
atcaatcgtg ataaaggttg gattttgaca aaacaaagag ccacactctg ggagcagtcg 28860
acggacgtca ccacgtgcat tttcggctaa tcttataatc tataaatgtt gaggtttaca 28920
gttctcgggg cgagatcaaa tttaagtata tagtcgtatc cgaagcgtta aatcacttat 28980
tcgccatgct tgaaagcgcc tcatgctttt cactgattca ttagctctat gtatggcaat 29040
ctaagtacga agtctgtcgt aaggcttaaa aactaaatat tggtagctac cttagttaag 29100
gtacaaggat tgcacaattc agtaggcgtt ttttctgcta ttctcgaacg gaaagcttta 29160
ttaagacaaa gcttgatatc ccacgggatg aaccagaagt tctatgatat ctcagaagct 29220
actaaatttc gggggttggg tacaagttag ttgaacatac aaataggaat ttgattgtat 29280
ccttagtcga ttctaaacaa atcatagtaa acccgtgcaa agtatacata ttaattcata 29340
cggcgtttca aagaggcaat ggcttgactt gagctgaatt acagattatg agtaaccaca 29400
agatagagta aacactgtaa tccatgttta attgagacca cttaaagatg ctgatattat 29460
tttcaaaaca caatggttta ttgacaatta tttatacact gatacatctt gcggttcttg 29520
gtcgacccta cttacgatat aaatgaagca cgtttcatcc agattcatct atcgtagctc 29580
caaatacgaa ttcaacttgg cgtttatatc cagaaaagag ccctagaggt gatagacttt 29640
taagtctttg gactaccatg ggatatgttt cacgtatcga aatagtaatt attattctgc 29700
gtttgctttc atataagtga ggatgaagcc tttatattgg tttcttaatc ttcttatacc 29760
acgcgtgtat ctttcctagc cctttattga atctggaagt gtcttgttac tcaatgtcaa 29820
acccttgtca gcctcttgcg gtgatgcacg aaaaaaccga atggaatata aaatattaac 29880
tactcctaat tttaagtgcc ctcttctaga ttgaattcat atatcaatat agacttcgca 29940
aactagtgaa tgaggggtat gaatttatcc ggaataacaa aagggactaa gtattcgaga 30000
tacaaaccgt tagatagatg ctccagtctg catagtgaat ttttgatttt taaccattga 30060
aggaatcaat ttcacgatcc ttacgagtta agtcatcaga aaaagagacc attagcgctc 30120
cccctttgaa atagtacagt ttcaaacaat agcctgagta agttggtatt cgagatacta 30180
taaacttttc gatcatttga tgcccccaac ctatgtttaa agaactatta tctttagcct 30240
taaactaaca caggaaccag ctaagtcttg tttagcttca cttgggctgg ttacatatat 30300
aaaataatgt atgccgcaga atttgtccct tagcgaattg tagttgacca aaagtctatt 30360
actcattggc gttgtatcac ttttgtgtca ataggtatga ttaatctctt gaaaattttt 30420
acgacaatgg taaaagatta gaactactaa acaactgtta ataatcatgt cgctccgtag 30480
attgccaaga atcagttggg atgaatacgt tatttacaac gtacaaacta cgactgagtt 30540
ggtaccatcg tagtttatgc ctatgttgaa ccgcaattat acgtcttttg cccggatccc 30600
cactatctgt gaaatgtcaa acctgttcgt tacctttaca aaatacatag ctatatcata 30660
cgtaaaaata tgttaacgaa agatcgttca ctctttcttc ggaaagataa ccaaagaatt 30720
aggaggatat ggtgcgcaca tagaaagggc cggtaagtaa ctctggcctt catagaacaa 30780
tatgttataa tttggaaatt gtcggatagc gcgactatgt gcttaattgg tttaccttaa 30840
attttataat tgatgacaat aaaaattcac cggagaagtt ctaacgtaag tatatagtta 30900
taactgaacc attcgaagac ttactccctt aacttaatta gacctatttg ttttccctga 30960
ctcctaagtt ctatggttgg caatttatct acaaggagac acgtatcatt taaaaacaaa 31020
aaattggaaa cttccttagc tgttgtgctg ggaacgctca aatcagtact cttcttctct 31080
agaagttgca aggggggaat tttatcatgt cgaagtttgt tataggagtc attcaaccat 31140
aggctccatg atactaaaag tgctggtaaa ctacgggagt aagatacata tttctcgata 31200
atagaattca gaattcgaat gagtccttgg tcgactcaga tccgaatcga gagaacccaa 31260
cgaatatata atttttatta catatgttgt cttagacaga gtattcctta acatcaactg 31320
gttttcagat aataagtaac tgcaacagag tcaaatcata gatattgata gtagttagag 31380
aaccattgat aatgttacaa ccattttcta attttgatgt tttgtagaca attattagtt 31440
cagcgagcta tctaacagtt cttacatatc tctactcatg caataaattc tgcaagttcg 31500
acactaactc aacctaggta acatcaaata cggatacatt caggggttat tatgcaaaaa 31560
atgggcttag ggataataga cactttacaa attgcgcatg caatcgagat attttatgta 31620
tcgatataat atgcattttt atagaattgc ctcctagcgt aacataaaca aacctatcta 31680
tttgcttttt tatccacgca tattacgtcc gtaccatttc cggccattca ttaagatcgg 31740
aagtaccttg ttatacaaaa ttaaaccttt aataccctat cgcgcagatt taggaattaa 31800
tttaatcaac tttagtggat caattataga catttttaag tggtttcttc aaggtagcat 31860
ttaaatatca atgatgactt actaaggttc taaatgagag aattcaatta atctggttag 31920
acaaagggat ccgaagatat tttatgccaa ccattaaaag ggcgttcctc tgtctacaat 31980
aagcctttat ttttaaatct ttgaagaaat cgagaacacg actgttgtca atacaaatat 32040
gataagaaga gaacttcatc tttgcccccc aataatagta cagcttcaaa taatattcac 32100
agtaaaatgg tatgtctggt actaagactt tcatgactgt tcgacgttct tattttatgt 32160
ataaagagta gtgatcccat gtctggagat tattctacat ccaattgact ctaagcacag 32220
ccttcttggg ttgcttgtat attgaaaatg atatactcaa ctggacgaga ctcataagga 32280
attatgattg accataagac cgctatgtat cgacgtcgtc ttagtttagt actcataatt 32340
atcatcattc ttttagtgcc tattacaatg ttggtaaaag aataaaactg catcacactt 32400
cttgataatg aacttgctcg attgattgtt gagaaagttt agtgatgagt atgttattta 32460
aggcactcgt gttctgatag agttggatcc attgttaatt acgagtatat aactcttcaa 32520
taattcgctc tatacgcaaa ttcctattat ctgtgaaatg tttaacgcgt acggtaactc 32580
tataaaatat ttatctacgt tataccttag aatatcttaa cggacaatcg caatatatct 32640
acttgtactg attaatggga aagtaggtgc gaatattgaa ggtatggtaa acgccggtaa 32700
gtaattctag gcaacaagga atgttatttt tttaattata ttttaaggga ttgtacgtct 32760
aaatcattaa taaaatttgt tgaaatcacc ttgtttgaat ttgtaaaaat tcgtcttaaa 32820
actttcaccg ttaattaatg attactacag tataattcca gaatttacat tcttaagcta 32880
attaaactaa tctgtttccc taggcttcta taaaatcgcg tcagtgatta tcccccatgg 32940
agacggatgt ttttcgcaaa taataattta caaatttcta tgtcacttct gctgtcaaca 33000
gttttgttta tactattctt gttatgatgt agattcgtcg cgttattatc atgtcgaact 33060
tcataaaaag tgtcttttta ccatgcagat caagattctg aaagtacaga caagcagcaa 33120
atacgaaatt catatttttg atcacaaggc cacagacctc tagtaagatg tacgttaact 33180
gaggttcgtg tcggtagtac caaacgttca tgtaactctc acaatgcgaa ttgacctgct 33240
ttgagctctt ctatatacta actggtattc tggcgaaaca aagctgtggt agtattatgt 33300
catgagtatt aatagtagta agaaaatcag ggataatgtt tcaacggttt acttatttag 33360
aggtagtgtg aggtactttt acgtgaacta gcaaactaac atctctttta aattattact 33420
cttacaataa gttccgtgac gacatgatta tctcaacctg atatacaatt gatgttctta 33480
tattgaaaag ttattaagcg agatatgtat ttaagcatag tagacacatc acaagttgcg 33540
gatatcatta agacaattta taaatagttc cattgtggaa tcttataata taacctgata 33600
gcgttatatt ggtgaagatg gctaattacc ctctcaccgg cgctattagc ttccatacca 33660
attggcgcca ttcattaaga tccgttgttc cttacgaaaa aaaaatttat aagaaatcct 33720
gtaacatgcg gatttagtag tttttattaa caacattact ggagcaaact aaaacattta 33780
aagacagaat tttggcagag gcaattaata tcatatgatg tgaaattagg gtctatattg 33840
taataatttg ataaattaaa ttagataagg ggtttggaag ataatttagc acagttagtt 33900
ataggcggaa gatttgcctt caaaaagcga ttattgttat ttgtcttaag ttacagcgaa 33960
aacagcagtc gttaaaacaa aaatgatatg tccaatatta catctaagca aggcaatttc 34020
gcaacaggtt aaggtatttt ttatagaaaa attaaaggtc cagttcaaac actttcattt 34080
gtgtagctcg tttatgcata tggtatgtaa actagtgcgt cggtgtatgg agatcttcct 34140
tcttgcgtat gattgcatgg actgcgatca cgttttgtaa gttcattgag actgttacgc 34200
ttaactgctc gaaattcgag aaaatatacg actgttcgta agagcgcttt gatcgaacac 34260
gatcataaca gagcacacat gataatcatc acttttttag tccctattac aaagcagcca 34320
agtgaatata tgtctatcac tcactatgaa tttgcatatg atcgttttat tgtagaaata 34380
atttaataaa tagaatgtta atgaagggtc tactgtactt atacaattgg gctacatgtt 34440
aactacaaga ctatatccta ttattgactt agtgtataca taatatggtt tcatatatgt 34500
agtgttcaag ggctatagca aatctgatga taaatgatta gggtaacacc ttagaataat 34560
atactagcct atcggaacac aagcacttct gccgtataat ccgagtgtgg ccacgataat 34620
ggaaggtatg gtcgaccgtt gttgctaata gtaggcgata acctatcctt ttttcataaa 34680
ttttctttag aacattgttc acataatata tcaggattaa ttgatgtaat gagctcgctt 34740
gattttgaaa acttgtgttt ttaattcgtc tccgattaat acactatact aaattttaaa 34800
gccagatata tcaatattaa actatttaat ttaacctaat cctcaaacgt tctattaaac 34860
cgtgtcaatc aatatctgct tcctaaatga aactttttcg ccaaaatcaa tagttagaat 34920
ctaaagtcgc tttcgtcctt agctatattg atttctttat acaggtagta acgtagattc 34980
attccgtaaa acggtttttc atttggatat aaaacatttc tttgatctcc aggagaaata 35040
tgagaaacta aacacgtcga gtaaatacgt atactgctca tttgtccacg cacccacata 35100
cctctggaag gaaaaacaca tactaaccta cctgacgcta gtgtaaaata tccaagagac 35160
cctgacagtg cgatttaacg agcctttaac tctttcatta gctgataagc attattgcga 35220
aactagcttg agcttgtatt gtccagtgtg tagtattaga agtgaaaaaa tcagggttaa 35280
taactcgtgg cgtcatttac atactgttag ccagtgacag gtaaacgtat actagcataa 35340
cgatatctta attaaattat ttatcttaca cattcttcct agatgacatg aatatgctgg 35400
tgcgatgtat aattgaactt ctgatatagg ataagaactg gaacacatat gtattatact 35460
aatgcatgta catcctaagt tttcaatatc gtttagagta caatttacaa atccctttcc 35520
ggaatcataa tataagatcg gatagccttg tgttcgtgga aagggcacat tagggtcaca 35580
gtggtggtat tacttatcaa actagctagc aataacgata atcatgtact actgaacagg 35640
aaaattgtat ttaaaagaag acttataact aatgttttac atagtcctaa ttgattacat 35700
tactcggggg aactaaaacc catgaccact aaaataaagc tgagtctaat tatgtgattt 35760
gatttaaaat ttcgatctat ataattataa tttcgagaga taaattggat tagctatttg 35820
ctagatgatt tggcacagaa tgacacagac gaagaactta ctatgaaata gcggtttcag 35880
ttgtcaatga tggatttcag cgaaactagg aaacgatgta gcttaagaaa tatctctctc 35940
attgcattta gataaagcat cttgctaaaa agagaaccag tactttgtaa agtaactaga 36000
ggttctcttt atactctgtg atttgtccag ttcttaaaag caaacgagga gtaatcaggt 36060
gcgtgggtaa aagcagacct tcatttttaa gtatgattag atggactacg attacatttt 36120
atgggatctc tgcgactgtc acgctaaaac actcggaaaa tgacaatcca atccacaact 36180
agttataacc cactgatcga aatggagcat aacgggtcac acatcataaa tttcactatt 36240
ttagtccgaa tttttcagca ttgcggtaga tgtgtaacaa ccgaccactg accatctaca 36300
tattattata ttccataaga tttaacttaa tatatagaaa acgcaagtag gatctactgt 36360
acttatatca ccatgctaca tattaagatg taagctaaat ccaattcttg tccttgagca 36420
tatatatcaa aaatacgaac attttggatt caaaagttat agcaaatccc accctaaacg 36480
tttggggaat ggttttagta ttatattcta gcctattaga acagaagcac cattcccatg 36540
taaacccagc gtcttcatca cattgaatac tttcatcgat taatattgtt tttaatatat 36600
gatgactcga ccttctaaca taaattttct actgattatt tataacaata tgtaccagga 36660
ttaaccaagg tactgagcgc ccatggtttt gggtactggt gattttattt cgactcaaat 36720
ttgcgcacta aagtaaattt taaagttaga catacagata ttataggtct ctatatgacg 36780
taaacgataa tcaaatagct aaaccgtatg ttactgagtc tgcttcttga gtgatacttt 36840
agccccttag tctacggtta ctagcaaaac tagttttgtt ctttcgatac accgaattgt 36900
ttatgaagag agtaacataa atctattttg tagaacgact ttattctagg tcatgaaaca 36960
tttcgttcat ctctaagaat attacaagac atcaagtagc ccaagatttt tcgtttgctc 37020
ctgattaatc cacgcaccca ttttcggatc gatgtaaaaa ttcattttag tctatttgat 37080
actattcaaa tataccctag gcacgcagtc agacgcatta tgagactctt ttactgttag 37140
gttaggtgtt gttcgatact gggtgtctgc caatacctca tattgcccac agtgtcgaat 37200
ttaaatcggt caaattaggt cctcaaagtt gtaacgccat ctccacattg ttgggtggtg 37260
accggtaggt gtataataat ataaggtatt gaaaattgaa ttaaatatac tttgcgcccg 37320
ttctacatga aataaattca gtcgaacgat gcaagaatct acattcgaac caagttatga 37380
gcgcgaactc ctatttaaag tttttatcgt tcaaaaacct gagagtttaa caacgtttta 37440
cgtgggacat gcaaacccct taccaatgtc gaaatatagg aatgaacaaa tctgtcttcg 37500
tgctaagggt acaattagga cgctgaagta atgtaactta tatgcaaggc aaattataac 37560
aaaaattaaa ttccagtaag gtggaagatt gtgatttaaa gatgactaat aaatattgtt 37620
atacatcctc ctaatcggtt ctacggttta cgagcaccaa aatccaagac ctctaaaata 37680
aagctaagtt tagacgcgtg attatactta agatatcaaa ctgttcgtct attatatcca 37740
gagatattct gtatctctta ttaatttatc gatctcgtat acaatgactc atttatagaa 37800
ctcagtatag aatctaagga tcgggtgcca atgatccttc cgatcagaac atgaaagcta 37860
tgtggtctga cgattacttc tctcaatgtc tttagaaaaa aaatcccgct gcaataggat 37920
ccagtactta gtaaagcagg ttgtgaatct tataatgttt tgaagatcat tggattttaa 37980
aaaccaaacg tggactgatt agaaacgtaa gctaaaatct agccacattt ctaactagtt 38040
tcagataaat tataataggt ttatatggta tgcgtacccc attctgcata atactttaag 38100
agaaagacaa tccaatgttg atcaagcttt gaattacaaa cgattatgat gtaatagggg 38160
tgttatggct tatattaagc cagaaatttt taggagtatc aacattgccc ttcggctcta 38220
ataactcact agtggtcatc gacatgataa tatattcgat aatttttaac taattttatt 38280
tgtatggcgg gcataatata tttagtttga gtctgcttgc aacgatgtta gacataagct 38340
tggttcaata ctcgcgctta aagaataatt tcaaaaacag cgagtgtttg gtgtcccaaa 38400
tagttactaa atgcaccctg tacgctagca taacggttac tactttatat ccattcttca 38460
atagacagaa agaagattct ctcgttaatt ttccaacttc tttacattgt atatacgttc 38520
cctttaattt cctattagaa ttaaggacat tccatcatct aacactaaat ttctactgat 38580
ttattataac aacatgtagg tggattaggc aagacccgaa atgctggttg tctttggttc 38640
tggatatttt ttctcgaact atatctgcgc gttaatatga attctataga tctacaagca 38700
gaaaagataa gtcggtttaa gacaatggga aaagttagat acctagagta ttaattattg 38760
agtaaatatc ttctcatata tgatagattc ctaccccccg gttgctagga aggttagtct 38820
tgtagtttcc atagacctga ctgctaaaga agagagtttc tgatatcttt tttttagggc 38880
gacgtaatcc tagatggtga ttcaaatgga ccaacattta gaacattaca attcttctag 38940
ttacctagta tttttatttt gcacctggga aatcattgct tttgattcta gatctgtgta 39000
aagattgatc agacttgaat taaatttgtc caaattatcc atgtgcatga gacaacatat 39060
attatgaaat tcacttttca aaaggtcaca actagttgga gacttattgt ttgctaatat 39120
tacattatcc tcacattagc gattgtagtt ggctctctaa aaatcgtcat agtaccaatg 39180
gggagccgag attattgagt gattaccagt agctaaacta tttaataagc tattaaagat 39240
tgatcaaagt aaacataccg cctgaaatat ataaatcata gtcagaccaa cattgctaca 39300
attcgtattc gcaccaactt ttgaccgcgt atttcccatt taagcttttg ttgctcacaa 39360
aacacttggt atacctatca atctcatggg acatgcgatc gtactgtgta cgaaggtatt 39420
tcggtaagaa gttatgtcac ttttatctaa gtaagcaaat aaaaagataa aaaaatgcaa 39480
tatatatgca agggaaatta atggacgatc ttaattcctg taaggtaaca cattgtgact 39540
caaaaatcat taaataatat aattgtacat ctggctaatc cgttctgggc ttttcaacca 39600
acagtaacgg agacttatta aaaagatttt gatacggacg cgcaactatt gttaggtaac 39660
tttgaagtcc gtcttttcga atcagccaaa ttcacttacc tttttgaatc ttcggatgtc 39720
ataattaata gctcgtttat agaagagtat acactatcta agggtggagg gccaagaatc 39780
cttccaatta ctacattaaa gatatctgca ctgacgtttt ctcttctcaa ggacaaaagt 39840
aaaaaaatgc cattgcacta ggatttaccg caaagattac ctcgttgtat atattgcagt 39900
cttaagaaca tcaatggatc ataaaaataa aacatgcatc ctttactatt aaaatctaag 39960
ttctagacaa attaccaatt agtctgaact tacattaaag agatttaata ggtacacgat 40020
ctctgtcgta taaattactt taactgaaat gttttccagt attaatcaat ccctgaatag 40080
catacaatta taatgagact agactataaa cgttagcaac gacagagaga ttattagcag 40140
catcatagtt acctctccgc tctagtatca cacaaatggt cgtcgatcag atagattggt 40200
cgataatctc catgaactat cgtctgtatg gcggacttta taaatttagt atcagtctgg 40260
tttaaatgat gttgagcatt agtgtgctta aaaaccgtca cataaagcgt atattcgaaa 40320
acaacgagtg tcttgtgaac catatgcata attagagtac tctgtagact agtatgacac 40380
atggctccac aaagctattt atcgatacaa tataaataga tatattcggc tatttttctg 40440
tttatatccg taatatttac gttgttttta attacttgcc agagttaaag acattccata 40500
gtgtggaact gggttttgag tttttcacta tataaacttg atgactactt tggctagtcc 40560
cgacaagtta gttctgaatg ccctcgaata atacttctaa aacaatgcct ggctgttgac 40620
agcagtgcat tgaaacttca ggcagaaaag cctagccggc ttaaccaagt ggaaaaactt 40680
agaagcgttc tattatgatt atcgaggaaa tatattctca tttgtgacag atttccacct 40740
ccggatactt agaaaggtta taggaataat tactattgag gtgagtacag tggagatgat 40800
atcatgttta cattatatga cggtaacgtg atcctgaatg ccgtttatga tagagtaatg 40860
tatttaacgt cggaattcct gtagttatct agtatttata tttcgaatat aggagataac 40920
attttaacat tcaagaattg tttcatgcat aatcagtctt gaatgtaatt actctaattc 40980
atcaatgtgt caaagacagt atatttaatc aagtaaagtt tagaaaaaga cataatcagt 41040
tacggagtta tcctatctta atattactct gatgtaatat ttgcaatcgc tgctgtctct 41100
ccaacattcg ccgtaatatc aatagagagg caagctcttg ctatgttttt caagggcatg 41160
tctaactatc caatcataag agggactcga tagcagacgt actgcctgaa atatcatcat 41220
gttagtgaaa ttaaattaag taccagtcgt aaagacacga ttttttagca gtttatttcg 41280
catataagct tttgttactt acacgatact tggtattcgt aatgatctca tgaggcgtct 41340
gttcatactg tattccgagg cgctccgata aattgctatg atatagttat ttatattagt 41400
cgataaaaag acaaatatag cgattaaaaa tgcaacaaat attaacgaac ggtctcaaat 41460
agtagaagat atccctcctc cggccatctc ctaaaatgcc atatattcgg attactgatg 41520
atgctcatca gggcagtttt atctagtctt ataggtgttt attttgaggt tattgttacc 41580
gaccgagaac cgtcgtgtcg tagctttgaa ctccgtgttt ccggattgtc tgacttggtt 41640
cacctttttg aatcttcgta ggattatact aattgacact ttttctaaaa gtaaacactc 41700
cctataggta gtggtcaatg agtttttgca ttatccttat tattgataat tctactcttg 41760
tcacgtgtat tacagtacaa acttattata ccaccatacc actagatctt atggagaata 41820
ctctctcaat acataaattg gagccacaga gacatgtata gatgataaat atagagatta 41880
tgtcctcaat tgtataattg tgagttctta acaaagaagg tatatgtcag aactttcact 41940
aatgacatta ggtatttgga cagtttcagt gatatagatt aattcatttc agatcttttt 42000
acgtattagt taatgcctca atagagttga attataataa cactatatta taaacgtcag 42060
cgacgacaga gaggttgaaa gcggcattct agtaatttgt tcgtttgaga acaatataaa 42120
atgttcctgt acagattgat gggatagtgt tctccctagg ctgtccactc cataatcgtc 42180
cttatagtag tacagtcgct ttaatttaat acgtggtcag cattttagtg ccaaataatc 42240
gtcaaattga acgcatatca gattgcgatg tatgtgctat ggacctttag cattactaga 42300
atcattccca aacaattttg ccataaggct ccgccacgca attaaacgat accataccaa 42360
taagaataat gtgccaaatc tttgttaata tcaccaattc ttacgttgat caataatgct 42420
tgccggagct tatcatcttt taaaggaagg acgcccgaag aggactttac ggtaaatatg 42480
cccaataact tcggccaatg atgctgtcta aataggttgg agtttccaga tataaggctc 42540
gaataagaat cggttataca acgcagcaca gggtcgaaac ttacgcaatt gtggcctaac 42600
agactgaatc aagtcgaaaa tctaaggagt aacccaatat gattgactgt gaataagaaa 42660
tttattcctg gggaataacc ctcaccattt actctaaacc ctaataggaa taaagattac 42720
taaaatgggg agagcgtact taatgtcatg ctcgaataaa atggtcctat agtgaactag 42780
ttcacctcct atgagaaagt taagaactta acctggatgt ctctacttac ataatctacc 42840
tgcatgcgta atacacgagt caacatatta acacacaaaa gttccttcct ccatatgcag 42900
ttaagcaagt catagctgta ttccataaac ctttcaaagt cactgtatct ggttatctaa 42960
agtctagaga aatgggtagt catttatggt aatatctcaa ttaagtttaa atgcgataaa 43020
ttgtgtacca tgctaatcta tgacgacttc gactctcttg ctgaaatttt ccacttcctt 43080
atgtggcctg acgaatactt ctctcattgt ttttagataa aagatcttgc tgaaatagga 43140
tccagtactt tgtaaagcaa gttgagaatc ttataatgtt ttgaagatca tcgggttcta 43200
aaaaccaaac gtggactaat taggtgcgtg ggtaaaaatc tagctacatt tctaagtagt 43260
ttcagataaa ttatgataag tttatatggg atgcgtacgc cagtctgcat aatactttga 43320
gagaatgaca atccaatcta gatcaagcta tgaattacaa acggttatga agtaaaacgg 43380
gtgttacagc ttaaatttag ccagaataat ttaggagttt caacattgcc gtagaggtgt 43440
aacaactcac cagtggccat ccacatatta atatattcca taacttttaa ctaattttat 43500
ttgtaacgcg ggcaaaatat attttgttta agtctgcttg ctacgatctt agacataagc 43560
ttggttcaat actcgcgctt aaagaaaaat ttcaaaaaca gcaagttttt ggactctcaa 43620
attgttacaa aatgcaccct gtacgttagg ggaatggtta ctactttata tccattcttg 43680
tttagacaga agcacgattc ccatgttaat cctccaactt cattacattg aatatacgtt 43740
ccctttaatt ttctatttga tttaaggtca ttccatcatc taacactaaa tttctactga 43800
ttatttataa caatatgtag gaggattagg caagatgcga aatgctggtt gtttttggtt 43860
ctggacattt tatctcgaat taaatctgcg cattaatatg aattctatag attgacaagc 43920
agaaaacata ggtctcttta agacaatggg aataattaaa tacctagagc ataaattact 43980
gagtaaatat cttgactcat atcatagatt cctagccccc ggttgctagg aaggttagtc 44040
ttgtagtttc catagaccag actgctaaag aagagagtta ctgatatctt ttttttaggg 44100
cgacgtaatc ctagatgatg attcatatgg accaacactt agaatattac aaatcttcta 44160
gttacctaat atttttgatt tgcacctggg aaatcattgc attcgatttt agatcggtgt 44220
aaagattgat caaactccat ttaattttat ccaaatttac catatgcatg ggataacacg 44280
tattatgaaa ttcacttttc gttaggttac aactagttcg agacttattg tttgctaata 44340
ctacattatc ctcacattag cgaatgtaat tggctctcta aaaatcctca tagttgtaat 44400
gggaagccga gattattgag tgatcaccag tagctgtact attttataag ctattaaaaa 44460
ttgattaaaa taaacatacc gcctgtaata tataaatcat agtcagacga acattgctac 44520
aatctgtatt cgtaccaagt tatgagcgcg tatttcttat ttaagttttt gtcgctcaca 44580
aaacactggg tttaccaatc attcacatgg gacatgcgat cgtactgcct atgatgatat 44640
attggtaaga agttatctgt ctttcttcta agagagcaat taaaaggtta aagaaatgca 44700
atatatatgc aagggaaatt aatggataat cttaattcct gtaaggtagc acattgtgac 44760
ttaaaaatga ctaaataata ttgttgtaca tctagctaat ccgttctggg ctttacgacc 44820
aacagtaacg aagacctatt aaaaagacct tgatatggac gcgcaactat agttaagtta 44880
cctagatgtc cgtcttttct attcagccaa attctcttac ctttttcaat ctttggatct 44940
cataattaat agctcgttta tagaagagta tatactatct aagggtggag ggccaaggat 45000
ccttccaatc acaacatcaa agatatctgg actgacgttt tctcctctca aggactatag 45060
aaaaaaaatc ccattgcatt aggatctacc acaaagatta cctggttgta aattttgcaa 45120
tgttaagaac atcaatggat cataaaaata aaacgtgcat cctttagtaa caaaatctaa 45180
gatctagaca aatttccaac tagtctgaac ttagattaaa gaggtttaat aggtacacga 45240
actctgtcgt atatattact ttaagtgaaa tgttttccag tgttgatcaa tctctgaata 45300
acaaacgatt ataatgaaat tagagtgtaa acgttaacaa cgaccgagag atttttagca 45360
gcatcatagt tacctctcgg ctctagtatc tcacaaatgg tcatcgattt gataaattgc 45420
tcgataattt ctatgtactt tcatttgtat ggcggacttt ataaatttag tatcagtctg 45480
gtttaaacga tgttgagcat aagtgtgctt gaaaactgcc acataaaggg taaattcgaa 45540
aacaacgagt gttttgtgaa ccatatgcat aattagagta ccctgtacgc tagcatgaca 45600
catgcctcca caaagctatt cttcaataca gtataaatag attcattcgt ctatttttct 45660
atttatatgc gttatattta cgttgtcttt aattacctgc tagaattaaa gacattccat 45720
tgtgtaggac tgagttttca gtaattcatt atattaactt gaagaccaat taggcaagac 45780
ccgacaagtt ggttgtgaat gcctccgaat aattcttcta aaactatgcc tgggtgttga 45840
cagcaatcca ttgaaacttc aggcagaaaa gcttagccgg tttaagtgaa tggaaaaact 45900
tagaagcgtt ctgtattgat tatcgaggaa atattttctc atttgtgaca gatttccacc 45960
tcccggttct taggaaggtt aaaggtgtaa ttactattga cgtgactgca gaggagaaga 46020
gatcttgttt tcatttttta acggtaacgt gatcctgaat ggcgtttata atggagcaat 46080
atatttaacg tcggaattct tgtagttatc tagtattttt attttgtata taggagataa 46140
taattttaca ttcaagattt gtttcatgct taatcagtct tgaatgtaat ttctctaaat 46200
catccatgtg ccagagacag catatttaat gaaataaact ttacaaaagg tcataattag 46260
ttagggagtt atcgtatgtt aatattactc tgatctgata tttgcaatcg ctgctgtctc 46320
tccaatattc gccgtaatat caatagagag gcgagatcat actgtgtttt ccaacggcaa 46380
gtctatctaa ccagttatta gaggaacttg atagcagaca taccgcctga aatatttaca 46440
tcttagtcag attaaattta ctacgactcg taaacacacg attttttggc agtgtatttc 46500
gcatataagc ttttgttgct tacaggacac ttggtatacg taatgatctc atgagacatc 46560
tgttcatact gtgtaccgag gtgttccgat aaatagctat gttatattta tctatataag 46620
ccgataaaaa gacaaatata ggcattaaaa atgcaacaaa tattaatgaa cggtctcaat 46680
tagtgaaagg tatcgctcct tggcccatat ctcaaaaagc gatatattcg aactactgat 46740
gaagcccatc agggctgttc tatctagact tacgggagct tattttgagg tttttgttac 46800
ggaccgacaa ccgtcgtgac gtaactttga agtccgtctt tccggatcga ccgaattggt 46860
tcaccttttt gaatcttcgt aggattatac taatagttgc tttttgtaaa agtaaacact 46920
ccctataggt ggtggtctat gagtttttcc attatcctta ttattgataa ttctactcat 46980
gtcacctcta ctatagtaca aatttattat actaccattg cactagatct tacggcgaat 47040
actctctcat tacataaatt ggagcctcag ggacatcaat agatgataaa tataaagttt 47100
atgtcctcaa ttgtaaaatt gtaagttctt aacaaagtac gtattagtca gaacttacat 47160
taatgacatt aggtatttac acagtttctg tgatatagat tagttcattt caaatctttt 47220
tccgtattag ttaatgcctc aatagaatag aattataata acactatatt ataaacgtta 47280
gcgacgacag agaggttgaa agcggcattc tagtaatctg tccgttcgag aacgatataa 47340
aatgttcccg tacagattga taggttagta ttctccctga gctgtcgtct ccatgacgga 47400
ctttatagta gtacaatcgc tttaatttaa tacatggtca gcatttctgt gccaaaaaat 47460
cgtcaaataa agcgtatatc cgaatacaat gaatgtgcta tggaccataa gcattactag 47520
aatactccgc agacaactat gtcataaggc tccgcgacgc aatttaacga tactatatca 47580
ataaaaataa tcagctattt ttctgtttat atcgctaatt cttacgttga ttaatattgc 47640
ttgccggagt ttatcatctt ttatagggag gaggcccgta gaggatttta cggtatataa 47700
gcctaataac ttctaccaat ggtgccgtca aaatagatca gagtatccag aaataaaact 47760
ccaataagaa tggctgacac taggcagcac aggatcgaaa cttacgctac aaaggcctaa 47820
cagactgaac caagtggaaa aactaagaag tatcccaata tgattaactg tgaataagat 47880
attcattcgt gaggaatatc cgtcaccact tactcaaaac cgtaatagga ataataacta 47940
ttaaaatgag gacagcgtac ataatgtcat gctcgaataa tatggtcgta tggtgaacta 48000
gaatacctcc tatgagaaag ttaagaactt aacctgggtg tctctgttca tatcttctat 48060
ttgcatctgt aatacaggag tcaacatatt aacacacaag agttctttct tccatatgca 48120
gttatgtaag tcattgctgt attccataaa cctgtcaaag tcactatatc tggttatgta 48180
aagtctagag aaatgcatag tcatttatgg aaatatctca actaagtata attgtgataa 48240
aatgtatgta gtggctgctg tttttccaac tttcaccgtg agatgattaa acaagtacac 48300
tcttgttatt tattataagc tcatgtgtaa ctaccctatc acaagagcga tccgacaggt 48360
gaagcattaa caggaaactc atcacgtcag cgtaattaaa ttatacacca gtcgtaaaat 48420
cgcactttat tagcagttta acatgcgtat agtctaaccc tacatacacg atacctgaaa 48480
atcgtaatga acttagtaac ggatagttaa aacggtattc cgaagcggtg cattaattcg 48540
ctaaggtatg gttgttctta ttacacggct tagatacaat tatagtggca aggaatacaa 48600
ttagttatta ccaacggcga cgaatagtag tttatttcct tcctgcgggc tcctcctgaa 48660
atgccactta tacggcttat tgaagccgat tagtacaata gatttattca acctcaaagg 48720
tctatattcc cggcttattc ttagctgata tgtcgcgtcg agtcccgggt ttgagtgcgt 48780
taacaccgga ttgtctggct tagttcaact tttggatacc tcatcgggtt atactaactg 48840
acacttattc tttaaataag gttcccttat tgggactagt aactgagatt tgaaattatc 48900
cttatttcta atgatcttaa ctctttcgca tgaataacag tacgagctta ctttacgagg 48960
ttatcactta ttcaagtgca ggatactctt ccaattcttg aaaaggacgt agagagttga 49020
atgtattaga tgggcgtacg cattatgtgc tcacttgtat aattgtgtgt tttcaaggaa 49080
ggaagtatgc atcaattcgt tcagtatcga cataaggtat ttggaaagtt ttagtgacat 49140
agtccaatag atttttgatc tctttaccga tcagtaaata ccattataga gtcaattcag 49200
atttacgcta tttaacacac aacgccgagg ataaaagggc tgaaattgac agtctacaat 49260
attgttcatg tgtcaacaat taacaataaa cgaatacacg ttgatgcgat agtgctctgg 49320
ctaggccgtc cacttcgtat attttctttg agtagtgtag acgtattaat atagcatgta 49380
gccagattct tagcatgaaa cgatgattaa aatgtacgca taccacgttg agatgtatgt 49440
gctatagact tttagtgtta cctgaaacat agtccatcga ttttgccata agactacggc 49500
acgaaattaa gtgatttcac acctacaaga gaaatgtgcc gaatctatga taataacacc 49560
gttcgttgaa ttaatcaata atggtagcgg ttgcatatta tcaaatgaag gagccacacc 49620
cggggaggag tttacggtcg atatcccgta caacttcggc taatcatgtt atctaaataa 49680
gttggggttt gcagttgtca gggcgaaatc agattcgact atacagccca gttcagagcc 49740
ctaactcacg taatcgtgac cttacagagc gagtcaagtt aattacctat cgagtagctc 49800
aatatgagag agtgtgaata agaaatttat tgcaaggcaa taatcctaat tattgatagc 49860
aaactttgat aagaataaag aatagcacaa ttcagaaagc gtacttactg tcatactcga 49920
atgaaatgct ttattaaaga aaaagttgac gtcctatgag aagattaaga acttctcctg 49980
catctcacaa cctacttaat cttcggggat gggtaataga taggtgaaca tataaataga 50040
gataagtttc taccttcaaa cgtagttaaa caagtcatag ctatatccca caaacctttc 50100
ataatcactg tatcgggata tctaagaagt aatggtatgg ctagtgatca atcataattt 50160
gtcagttaag acaagatgcg gtaaattgtg tattgcgagt cctattgtct cgacttaaac 50220
tgtctgatgt tataacaaat acacagtagt taattgtcaa ttgcttatgt actgctacgc 50280
cttgtggaga ccggtccggc gcgtgaagga tataaatgaa actcgtcaca tccacattat 50340
tatatcgtac atcggagtac gaatcgaact tggcctctat ttttagatgc gtgcgctgca 50400
agtgtaaatg taccaaatct aaaaattacg atgggttttg tttcaggtat ccaaaaagta 50460
attctgatgc cgcgcttcaa ttcactaaag tgaggatgtt gtctttatac gggtttgata 50520
cttttattgt accaagcatc tttattagtt agcactatcc ccaacgtata acagtttact 50580
ttctcggtgt gagcccctcg tcaactgcct gcagtagtgc acgttgaagc cgattagaat 50640
attagatttt ttcaactcca aacgtcaaca gtcccgctct agtttaagtt catatatcag 50700
gacaggtctc ggaattaagt gtataagcgc tgggaacttt cgcgcagttc gaatagtgag 50760
taagtgatcg agttacacac cgttagattc atccttcaga taacgttccg tttttttgat 50820
ttataactat cgtttgaatc aattccatct tcttaacgtg ttaagtcatc cgcaaaaaag 50880
acgatatgag cttaccttac gaaataattt catttcgaac tacagggtgc tctacttgct 50940
cttgaagata tcgtagagtg ttggatgaat taaaaccccc tacccatttt caatcgactt 51000
gtatgtttat ccttaaacta acatggaaat ttgctttgat ttgtttagta tcatttaggc 51060
gtgtttcaaa tgtataatta agtatgccgc atagtttctc cattaccgaa ctgaacacca 51120
cttagtgtca aacactcatt gctgttctac gccatttatg acattacgct caaattaact 51180
gagctgaatt tcaaagacta taatattatt tttgtgttac caattaacag ttaacgaata 51240
cgtgacgatg tagaacacca ggagccaggt cggacgcatc ctatatttac ttcgtgcaga 51300
gtaggtctaa caagatagca tggaggttta tgcttaagtt gaaccgcaga taaaggtcta 51360
tactcgggat cttcactatc tgaaggttta gaattttaat ggtaccctat acaaagtgca 51420
taggtttttc attaatatta agacgcaaag gtaagtgaat tcactcctac aacggaaata 51480
tgaccaaagt atcaaaacaa tatggttcgt agaaaaaatc gatcgtgata aaggttggat 51540
tttgacaaaa caaagagcta cagtctggga acagtcgatg gacgccacca cgtgcttttt 51600
cggctaatct tataatttat aaatgttgag gtttagaatt ctcgggacga gatcaaattt 51660
aagtatatag tcatatccga agcgttaaat cacttattcg ccatgcttaa aagcgcctca 51720
tgcttttcac tgattcatta gctctatgta tggcaatcta tgtacgaagt ctgtcgtaag 51780
acttaaaaac taaatattgg tagcttcctt agttaaagta caaggattgc acaattcagt 51840
agacattttt tctggtattc ccgaacggaa agctttatta agacaaagtt tgatatccga 51900
cgggatgaac cacaagttct atgatatctc agaagctact aaatttcggg ggttgggtac 51960
aagttagttg aacatacaaa ttggaatttg attgtatcct tggtcgattc taaacaaatc 52020
gtagtaaacc cgtgcaaagt atatatatta tttcatacgg cgtttcaaag aggcaatggc 52080
ttgacatgag ctggatttca gattatgagt aaccacaaga tagtgtaaac actgtaatcc 52140
atatttaatt gagatctctt aaaaatgctg atattatttt ctaaactcga tggtttattg 52200
acaattattt gtacagtgat acatctagcg gttcttggtc gaccctactt acgtaataaa 52260
tgtagcacgt ttgatccaga ctcatccatg gtagcttcaa atacggattc aacttggcgt 52320
ttatatccag aaaacggccc tagaggtgat agacatttaa cactttggac aaccattgga 52380
tatgtttcac gtatcgatat agtaattatt attctgcatt tgctttctag taagtgagga 52440
agaagccttt ctattggttt cttaatcctc ttataccacg cgtgtatctt tcctagccct 52500
ttattgaaac tggaagtgtc ttgttattca atgttaaacc cttgtcagcc tattgcggtg 52560
atgcacgaaa aaaccaaatg gaatataaaa tattaactac tcctaatttt aagtgccctc 52620
ttctagattg tattcatata tcaatataga cttcgcaaac tagtgaatga gggaaatgaa 52680
tttatccgga ataacaaaag ggactgagta ttcaagatac aaaccgttag atagatgttc 52740
cagtctgcat agtaaatttt tgttttttaa ccattgaagg aatcaatttc acgatcctta 52800
cgagtttagt catcagaaaa agagaccttt agcgctcccc ccttgaaata gtacagcttc 52860
aaacaataac ctgagtaagt tggtatccga ggtactataa atttttcgat catttgatgc 52920
ccccatccta tgtttaaaga actattatct ttagccttaa gcttacacag gaaccagctg 52980
agtctaggtt aggttcactt gggttgctta catatataaa ataatgtata ccgcagaatt 53040
tgtcccttag ggaattgtag ttgaccaaaa gtctattact cattggcgtt gtatcacttt 53100
tgtgtcaata ggtatgatca atctcttgga aattattacg atgttggtaa aagattagaa 53160
ctactaaaca actgttaata atcaagtcgc tccgtagatt gccaagaatc agttgagatg 53220
aatacgttat ttagaacgta caaactacga ttgagttggt accatcgtag tttatgccta 53280
tgttaatccc caattatacg tcttttgccc gaatccccac tatctgtgaa atgtttaacg 53340
tgttcgttac ctttacaaaa tacatagcta tatcatacgt aaaaatatct taacggaaga 53400
tcgtacactc tttcttcgga tagataagca aagaaatagg aggatatggt gcacacatgg 53460
aaagggccgg taagtaattc tggccttcat agaacaatat gttataattt ggaaattgtc 53520
ggatagcgcg actatgtgct taattggttt actttaaatt ttataattga tgacaataaa 53580
aattcaccgg agaagttcta acgtaagtat atagttataa ctgaacgatt ccaagattta 53640
ctcccttaag ttaattagac ctatttgttt tccctgactc ctaagtttta tggttggcaa 53700
tttatctgca aggagacaca tatcatttag aaataaaaaa ttggaaactt ctttagctgt 53760
tgtgctggga acgctcatat caatactttt cttctctaga agttgaaagg ggggaatatt 53820
atcatgtcga agtttgttat aagagtcatt ctaccataca caccatgatt ctgaaagtgc 53880
tggtaaacta cgggaataag atacatattt ctcattatta gaattcagac ctcaaatgag 53940
tcgttggtca actcagatcc gaatcgaaag aacccaacga atatataact tttattacat 54000
gtgttgtctt agtcagagta ttccttaaca ttaactggtt ttcagacgat atgtaactgc 54060
agcagagtca aatcatggat attgatagta gttagagaac cattgataat gttacaacca 54120
ttttctaatt ttgatgttgt gtagacaatt attagttgag cgagctaact aacagttctt 54180
acaaatctct actcatacaa taaattccgt gagctcaaca ctaactcaac ctaggtaaca 54240
tcaaatgccg atatattcag gggttattat gcgagatatg cgcttaggga taatagacac 54300
tttacaaatt gcgcatgcga tcgagatatt ttatgaatcg atataatatg cattcttata 54360
gaattgcctg ttagcgtaac ataaataaac gtatctaatt acttttttat ccacgcttat 54420
tacatccgta ccatttccgg ccattcatta agatcggaag taccttgcaa tacaaaatta 54480
aactttaaat accctatcac gcagatttag caattatttt aatcaacttt agtggatcaa 54540
tcatagacat ttttaagtgg tattttcaag gtggcattta aatattaatg atgacatatt 54600
aaggttttaa atgagagaat tcaattaatt tggttagaca aagggatccg aagatatttt 54660
atcgcaacca ttaaaagggc gtacctctgt ctacaataag cctttatttt taaatgtttg 54720
aagaaatcgt gaagacgact gttgtcaata caaatatgat aagaacagta ctacatcttt 54780
gctccgcaat aatagtacag cttcaagtaa tattcacagt aaaatggtat gtctggtact 54840
aagactttca tgactgttcg acgtttatac tttaagtata aagagtagtg atccgatgtc 54900
tggagattat tctacatcca attgactcta agcacagcct tcttggcttg ctagtacatt 54960
gaaagtgata tactcaactg gacgagactc gaaaggaaat atgattgacc ataagaccgc 55020
tttgtttcga catcgtctta gtacagtact cataattatc atcattcttt tagtgcctat 55080
tacaatgttg gcaaaagaat aaatctccat cacacttctt gaaaatgtac ttggtcgttt 55140
gattgttgag aaagtttaat gatgagtatg ttatttaagg cactggtgta ctgatagagt 55200
tggactaaat gttaattacg agtatataac tcttcaataa ttcgctctat acgcaaattc 55260
ctattatctg tgaaatgttt aacgcctatg gtaactctgt aaaatattta tctacgttat 55320
accttagaat atcttaacgg actatcgcaa tatatctact tgtactgatt aatgggaaag 55380
taggtgcgat aatcgaaggt atggtaaacg ccggtaagta attctaggca acaaggaatg 55440
ttattttttt aattattttt taaggcattg tacgtctaaa tcatcaataa aatttgttga 55500
aatcaccttg tttgattttg taaaaatttg tcttaaaact atcaccgtta attaaagatt 55560
actacactat aattccagaa tttacattct taagctattt aaactaatct gtttccctag 55620
gcttctataa aatcgcgtca gtgattatcc cccttggaga cggatgtttt tcgcaaataa 55680
caattaacaa atttctatgt cacttctgct gtcagcaatt ttgtttttac tatacttgtt 55740
atgatgtaga ttcgtcgcgt tattgcgttg tcgaacttca taaaaagtgt ctttttacca 55800
tgcagatcaa gattgtgaaa gtatagacaa gcagcaaata cgaaaataca actacagttt 55860
tagcggtaaa gtctatctaa atttaataat gtcagtgtta tgtgactact ttttatattt 55920
cttcgcaacc tttattatcg ttgttttaaa ccaaattgcc acttacttct aaacgtcaat 55980
cagcctcttg gattacaaca atttagtcga taacttcgtc gatctcttag gatttttcat 56040
gttaatgctc tgatacattt ttgtagcctg atattttgtc tgtttctgcc ataacaactc 56100
gatccgacag gtgaggtatt agcaggaata tcatcatgtc agcgtaatta aattatgcac 56160
cagtcgtaaa atcacggttt attagcagtt taacatgcgt atagtctaac cctacataca 56220
cgatacctga aaatcgtaat gatcttagta agggattgtt aaaacggtat tccgaggcgg 56280
tgcattaatt tgctatggta tggttattct tattacacgg tttagaaaca attatagtgg 56340
ctaagaatgc aactagttat tacgaacggc cacgaatagt agaaaatttc cttcctgcgg 56400
gcttctcctg aaatgccatt tatacgggtt attgaagccg gttactacga cagatttatt 56460
caacctcaaa ggtctatatt cccagcttat tcttagccga tatgttgcgt cgtgtcccag 56520
ctttgaatgc gttaacaccg gattgtctga cttagttcag cttttggata cctcatcggg 56580
ttatactaac tgacacttat tctttaaata aggatccctt attgggagtg gtaagtgaga 56640
tttgggatta tccttatttc taatgatctt acccctttcg catgaataac agtacgagct 56700
tattttacga ggatatcact tgatcaagtg gaggatactc ttccaattct tgaataggac 56760
ctagagagtt gaatgtatta gatggacgta cgcattatgt gctcagttgt ataattgtgt 56820
gttttcaagg aaggaagtat gcgtcaattc gttcagtatc gacataaggt atttggaaag 56880
ttttagtgac atagaccaat agattttaga tctctttacc catcagtaaa taccattata 56940
gagtcaattc aaatttacgc tatttaacac acaacgccga ggataaaagg gctgaaattg 57000
acagtctact attttgttca tgtgtgaaca attaacaata ttcgaataca cgttgatgcg 57060
atagtgctct ggctaggctg tccacttcgt atattttctt tgagtagtgc agacgtatta 57120
atataatatg tagccaggat cttagcatga aacgatgatt aaaatgtacg cataccacgt 57180
tgggatgtat gtgctataga cttttagtat tacctgaaac atagtccatc gattttgcca 57240
taagacttcg gcacgaaatt aagtgatttc acacctacaa gagaaatgtg ccgaatctat 57300
gataatatca ccgttcgttg tattaatcaa taatggtagc ggctgcatat tatcaaatga 57360
aggagcgaca cccggggagg agtttacggt ggatatcccg tacaacttcg gctaatcatg 57420
ttatctaaat aagttggggt ttgcagttat gagggcgaaa tcagattcga ctatacagcg 57480
cagttcagag ccctaactca cgtaatcgtg accttacaga gcgagtcaag ttgataacct 57540
atcgagtagc tcaatatgag tgagtgtgaa taagaaattt attgcaaggc aataatccta 57600
atcattgaca gcaaactttg ataagaataa agattagtac aattcagaaa gcgtacttac 57660
tgtcatactc gaatgaaatg ctttattaaa gaaaaagttg acgtcctatg agaagattaa 57720
gaacttctcc tgcatctcac aacttacata atcttcgggc atgggtaata gataggtgaa 57780
catataaata cagaaaagtt tctaccttca tacgtagtta agcaagtcat agctatatcc 57840
cataaacctt tcataatcac tgtatcgggt tatctaagaa ctaatggtat ggctagtcat 57900
ttatggtaat ttgtcagtta agtcaagatg cggtaaattg tgtattgcgg ctcctattat 57960
cccgacttaa actgtctgat gttataacaa atacacagta gttaattgtt atttgcttat 58020
gtactgctac gctttgtgga gaccggtccg gcgcgtgaag catataaatg aaactcatca 58080
catccacata attatatcgt acatcggtgt aggaatcgaa cttggcttct aattttacat 58140
gcgtgcgctg caagtgtaaa tataccaaat ctaaaaatca cgatgggctt tgtttcaggt 58200
atctaaaagg aaattctgat gccgcgcttc aattcactaa agtgtggatg ttctctttat 58260
acgggtttga tacttttatt gtagcaagca tctttattag ttaatactat ccccaacgta 58320
taatagttta cttcctcggt gtgggcccct cgtcaagtgc ctgctataga gcatgttgaa 58380
gccgattagt ataatagatt ttttcaactc caaacgtcaa cagtcccgct ttagtttaag 58440
ttcatatatc gggacaagtc tcggaattaa gtgcataagc gctgggatct ttcgcgcagt 58500
tcgaataatg agtaactgat cgagttacac accgtcagac ttattcttca gataacgttc 58560
cgttattacg attaataact atcgtttgaa actattccat cttcttaacg tgttaagtct 58620
ttcgcaaaaa agacggtatg agcttacctt acgaaataat ttcttttcga actacagggt 58680
gctctacttg ctcttgaaga aatcgtagag tgttggatga attaaaagcc cctacccatt 58740
ttctatcgac ttgtatgttt atccttattc taacatggaa gtttgcattg atttgtttag 58800
tatcaattag gcgtgtttca aatgtattaa taagaatgcc gtatagattc tccattaccg 58860
aactgaacac tacttagtat taaacagtca ttgctgttct acgccattta agacattacg 58920
ctcaaaataa ctgagctgaa tttcagagac tataatatta tttatgtgtc accaattaac 58980
agttaacgaa tacgtgacga tgtggaacac caggagccag gtcggacgca tcctatattt 59040
actttgtgca gagtaggtct aacaaaatag catgtaggtt tatgcttaag ttgaaccgca 59100
gataaaggtc tatactcggg atcttcacta tctgaaggtt tagattttta atggtaccct 59160
aaacaaagtg cataggtttt tcattaaaat tatggcgcaa agctaagtga attcactcct 59220
acaacagaaa tatgaccaaa gtatcaaaac aacatggttc gtagaaaaaa tcaatcgtga 59280
taaaggttgg attttgacaa aacaaagagc cacactctgg gagcagtcga cggacgtcac 59340
cacgtgcatt ttcggctaat cttataatct ataaatgttg aggtttacag ttctcggggc 59400
gagatcaaat ttaagtatat agtcgtatcc gaagcgttaa atcacttatt cgccatgctt 59460
gaaagcgcct catgcttttc actgattcat tagctctatg tatggcaatc taagtacgaa 59520
gtctgtcgta aggcttaaaa actaaatatt ggtagctacc ttagttaagg tacaaggatt 59580
gcacaattca gtaggcgttt tttctgctat tctcgaacgg aaagctttat taagacaaag 59640
cttgatatcc cacgggatga accagaagtt ctatgatatc tcagaagcta ctaaatttcg 59700
ggggttgggt acaagttagt tgaacataca aataggaatt tgattgtatc cttagtcgat 59760
tctaaacaaa tcatagtaaa cccgtgcaaa gtatacatat taattcatac ggcgtttcaa 59820
agaggcaatg gcttgacttg agctgaatta cagattatga gtaaccacaa gatagagtaa 59880
acactgtaat ccatgtttaa ttgagaccac ttaaagatgc tgatattatt ttcaaaacac 59940
aatggtttat tgacaattat ttatacactg atacatcttg cggttcttgg tcgaccctac 60000
ttacgatata aatgaagcac gtttcatcca gattcatcta tcgtagctcc aaatacgaat 60060
tcaacttggc gtttatatcc agaaaagagc cctagaggtg atagactttt aagtctttgg 60120
actaccatgg gatatgtttc acgtatcgaa atagtaatta ttattctgcg tttgctttca 60180
tataagtgag gatgaagcct ttatattggt ttcttaatct tcttatacca cgcgtgtatc 60240
tttcctagcc ctttattgaa tctggaagtg tcttgttact caatgtcaaa cccttgtcag 60300
cctcttgcgg tgatgcacga aaaaaccgaa tggaatataa aatattaact actcctaatt 60360
ttaagtgccc tcttctagat tgaattcata tatcaatata gacttcgcaa actagtgaat 60420
gaggggtatg aatttatccg gaataacaaa agggactaag tattcgagat acaaaccgtt 60480
agatagatgc tccagtctgc atagtgaatt tttgattttt aaccattgaa ggaatcaatt 60540
tcacgatcct tacgagttaa gtcatcagaa aaagagacca ttagcgctcc ccctttgaaa 60600
tagtacagtt tcaaacaata gcctgagtaa gttggtattc gagatactat aaacttttcg 60660
atcatttgat gcccccaacc tatgtttaaa gaactattat ctttagcctt aaactaacac 60720
aggaaccagc taagtcttgt ttagcttcac ttgggctggt tacatatata aaataatgta 60780
tgccgcagaa tttgtccctt agcgaattgt agttgaccaa aagtctatta ctcattggcg 60840
ttgtatcact tttgtgtcaa taggtatgat taatctcttg aaaattttta cgacaatggt 60900
aaaagattag aactactaaa caactgttaa taatcatgtc gctccgtaga ttgccaagaa 60960
tcagttggga tgaatacgtt atttacaacg tacaaactac gactgagttg gtaccatcgt 61020
agtttatgcc tatgttgaac cgcaattata cgtcttttgc ccggatcccc actatctgtg 61080
aaatgtcaaa cctgttcgtt acctttacaa aatacatagc tatatcatac gtaaaaatat 61140
gttaacgaaa gatcgttcac tctttcttcg gaaagataac caaagaatta ggaggatatg 61200
gtgcgcacat agaaagggcc ggtaagtaac tctggccttc atagaacaat atgttataat 61260
ttggaaattg tcggatagcg cgactatgtg cttaattggt ttaccttaaa ttttataatt 61320
gatgacaata aaaattcacc ggagaagttc taacgtaagt atatagttat aactgaacca 61380
ttcgaagact tactccctta acttaattag acctatttgt tttccctgac tcctaagttc 61440
tatggttggc aatttatcta caaggagaca cgtatcattt aaaaacaaaa aattggaaac 61500
ttccttagct gttgtgctgg gaacgctcaa atcagtactc ttcttctcta gaagttgcaa 61560
ggggggaatt ttatcatgtc gaagtttgtt ataggagtca ttcaaccata ggctccatga 61620
tactaaaagt gctggtaaac tacgggagta agatacatat ttctcgataa tagaattcag 61680
aattcgaatg agtccttggt cgactcagat ccgaatcgag agaacccaac gaatatataa 61740
tttttattac atatgttgtc ttagacagag tattccttaa catcaactgg ttttcagata 61800
ataagtaact gcaacagagt caaatcatag atattgatag tagttagaga accattgata 61860
atgttacaac cattttctaa ttttgatgtt ttgtagacaa ttattagttc agcgagctat 61920
ctaacagttc ttacatatct ctactcatgc aataaattct gcaagttcga cactaactca 61980
acctaggtaa catcaaatac ggatacattc aggggttatt atgcaaaaaa tgggcttagg 62040
gataatagac actttacaaa ttgcgcatgc aatcgagata ttttatgtat cgatataata 62100
tgcattttta tagaattgcc tcctagcgta acataaacaa acctatctat ttgctttttt 62160
atccacgcat attacgtccg taccatttcc ggccattcat taagatcgga agtaccttgt 62220
tatacaaaat taaaccttta ataccctatc gcgcagattt aggaattaat ttaatcaact 62280
ttagtggatc aattatagac atttttaagt ggtttcttca aggtagcatt taaatatcaa 62340
tgatgactta ctaaggttct aaatgagaga attcaattaa tctggttaga caaagggatc 62400
cgaagatatt ttatgccaac cattaaaagg gcgttcctct gtctacaata agcctttatt 62460
tttaaatctt tgaagaaatc gagaacacga ctgttgtcaa tacaaatatg ataagaagag 62520
aacttcatct ttgcccccca ataatagtac agcttcaaat aatattcaca gtaaaatggt 62580
atgtctggta ctaagacttt catgactgtt cgacgttctt attttatgta taaagagtag 62640
tgatcccatg tctggagatt attctacatc caattgactc taagcacagc cttcttgggt 62700
tgcttgtata ttgaaaatga tatactcaac tggacgagac tcataaggaa ttatgattga 62760
ccataagacc gctatgtatc gacgtcgtct tagtttagta ctcataatta tcatcattct 62820
tttagtgcct attacaatgt tggtaaaaga ataaaactgc atcacacttc ttgataatga 62880
acttgctcga ttgattgttg agaaagttta gtgatgagta tgttatttaa ggcactcgtg 62940
ttctgataga gttggatcca ttgttaatta cgagtatata actcttcaat aattcgctct 63000
atacgcaaat tcctattatc tgtgaaatgt ttaacgcgta cggtaactct ataaaatatt 63060
tatctacgtt ataccttaga atatcttaac ggacaatcgc aatatatcta cttgtactga 63120
ttaatgggaa agtaggtgcg aatattgaag gtatggtaaa cgccggtaag taattctagg 63180
caacaaggaa tgttattttt ttaattatat tttaagggat tgtacgtcta aatcattaat 63240
aaaatttgtt gaaatcacct tgtttgaatt tgtaaaaatt cgtcttaaaa ctttcaccgt 63300
taattaatga ttactacagt ataattccag aatttacatt cttaagctaa ttaaactaat 63360
ctgtttccct aggcttctat aaaatcgcgt cagtgattat cccccatgga gacggatgtt 63420
tttcgcaaat aataatttac aaatttctat gtcacttctg ctgtcaacag ttttgtttat 63480
actattcttg ttatgatgta gattcgtcgc gttattatca tgtcgaactt cataaaaagt 63540
gtctttttac catgcagatc aagattctga aagtacagac aagcagcaaa tacgaaattc 63600
atatttttga tcacaaggcc acagacctct agtaagatgt acgttaactg aggttcgtgt 63660
cggtagtacc aaacgttcat gtaactctca caatgcgaat tgacctgctt tgagctcttc 63720
tatatactaa ctggtattct ggcgaaacaa agctgtggta gtattatgtc atgagtatta 63780
atagtagtaa gaaaatcagg gataatgttt caacggttta cttatttaga ggtagtgtga 63840
ggtactttta cgtgaactag caaactaaca tctcttttaa attattactc ttacaataag 63900
ttccgtgacg acatgattat ctcaacctga tatacaattg atgttcttat attgaaaagt 63960
tattaagcga gatatgtatt taagcatagt agacacatca caagttgcgg atatcattaa 64020
gacaatttat aaatagttcc attgtggaat cttataatat aacctgatag cgttatattg 64080
gtgaagatgg ctaattaccc tctcaccggc gctattagct tccataccaa ttggcgccat 64140
tcattaagat ccgttgttcc ttacgaaaaa aaaatttata agaaatcctg taacatgcgg 64200
atttagtagt ttttattaac aacattactg gagcaaacta aaacatttaa agacagaatt 64260
ttggcagagg caattaatat catatgatgt gaaattaggg tctatattgt aataatttga 64320
taaattaaat tagataaggg gtttggaaga taatttagca cagttagtta taggcggaag 64380
atttgccttc aaaaagcgat tattgttatt tgtcttaagt tacagcgaaa acagcagtcg 64440
ttaaaacaaa aatgatatgt ccaatattac atctaagcaa ggcaatttcg caacaggtta 64500
aggtattttt tatagaaaaa ttaaaggtcc agttcaaaca ctttcatttg tgtagctcgt 64560
ttatgcatat ggtatgtaaa ctagtgcgtc ggtgtatgga gatcttcctt cttgcgtatg 64620
attgcatgga ctgcgatcac gttttgtaag ttcattgaga ctgttacgct taactgctcg 64680
aaattcgaga aaatatacga ctgttcgtaa gagcgctttg atcgaacacg atcataacag 64740
agcacacatg ataatcatca cttttttagt ccctattaca aagcagccaa gtgaatatat 64800
gtctatcact cactatgaat ttgcatatga tcgttttatt gtagaaataa tttaataaat 64860
agaatgttaa tgaagggtct actgtactta tacaattggg ctacatgtta actacaagac 64920
tatatcctat tattgactta gtgtatacat aatatggttt catatatgta gtgttcaagg 64980
gctatagcaa atctgatgat aaatgattag ggtaacacct tagaataata tactagccta 65040
tcggaacaca agcacttctg ccgtataatc cgagtgtggc cacgataatg gaaggtatgg 65100
tcgaccgttg ttgctaatag taggcgataa cctatccttt tttcataaat tttctttaga 65160
acattgttca cataatatat caggattaat tgatgtaatg agctcgcttg attttgaaaa 65220
cttgtgtttt taattcgtct ccgattaata cactatacta aattttaaag ccagatatat 65280
caatattaaa ctatttaatt taacctaatc ctcaaacgtt ctattaaacc gtgtcaatca 65340
atatctgctt cctaaatgaa actttttcgc caaaatcaat agttagaatc taaagtcgct 65400
ttcgtcctta gctatattga tttctttata caggtagtaa cgtagattca ttccgtaaaa 65460
cggtttttca tttggatata aaacatttct ttgatctcca ggagaaatat gagaaactaa 65520
acacgtcgag taaatacgta tactgctcat ttgtccacgc acccacatac ctctggaagg 65580
aaaaacacat actaacctac ctgacgctag tgtaaaatat ccaagagacc ctgacagtgc 65640
gatttaacga gcctttaact ctttcattag ctgataagca ttattgcgaa actagcttga 65700
gcttgtattg tccagtgtgt agtattagaa gtgaaaaaat cagggttaat aactcgtggc 65760
gtcatttaca tactgttagc cagtgacagg taaacgtata ctagcataac gatatcttaa 65820
ttaaattatt tatcttacac attcttccta gatgacatga atatgctggt gcgatgtata 65880
attgaacttc tgatatagga taagaactgg aacacatatg tattatacta atgcatgtac 65940
atcctaagtt ttcaatatcg tttagagtac aatttacaaa tccctttccg gaatcataat 66000
ataagatcgg atagccttgt gttcgtggaa agggcacatt agggtcacag tggtggtatt 66060
acttatcaaa ctagctagca ataacgataa tcatgtacta ctgaacagga aaattgtatt 66120
taaaagaaga cttataacta atgttttaca tagtcctaat tgattacatt actcggggga 66180
actaaaaccc atgaccacta aaataaagct gagtctaatt atgtgatttg atttaaaatt 66240
tcgatctata taattataat ttcgagagat aaattggatt agctatttgc tagatgattt 66300
ggcacagaat gacacagacg aagaacttac tatgaaatag cggtttcagt tgtcaatgat 66360
ggatttcagc gaaactagga aacgatgtag cttaagaaat atctctctca ttgcatttag 66420
ataaagcatc ttgctaaaaa gagaaccagt actttgtaaa gtaactagag gttctcttta 66480
tactctgtga tttgtccagt tcttaaaagc aaacgaggag taatcaggtg cgtgggtaaa 66540
agcagacctt catttttaag tatgattaga tggactacga ttacatttta tgggatctct 66600
gcgactgtca cgctaaaaca ctcggaaaat gacaatccaa tccacaacta gttataaccc 66660
actgatcgaa atggagcata acgggtcaca catcataaat ttcactattt tagtccgaat 66720
ttttcagcat tgcggtagat gtgtaacaac cgaccactga ccatctacat attattatat 66780
tccataagat ttaacttaat atatagaaaa cgcaagtagg atctactgta cttatatcac 66840
catgctacat attaagatgt aagctaaatc caattcttgt ccttgagcat atatatcaaa 66900
aatacgaaca ttttggattc aaaagttata gcaaatccca ccctaaacgt ttggggaatg 66960
gttttagtat tatattctag cctattagaa cagaagcacc attcccatgt aaacccagcg 67020
tcttcatcac attgaatact ttcatcgatt aatattgttt ttaatatatg atgactcgac 67080
cttctaacat aaattttcta ctgattattt ataacaatat gtaccaggat taaccaaggt 67140
actgagcgcc catggttttg ggtactggtg attttatttc gactcaaatt tgcgcactaa 67200
agtaaatttt aaagttagac atacagatat tataggtctc tatatgacgt aaacgataat 67260
caaatagcta aaccgtatgt tactgagtct gcttcttgag tgatacttta gccccttagt 67320
ctacggttac tagcaaaact agttttgttc tttcgataca ccgaattgtt tatgaagaga 67380
gtaacataaa tctattttgt agaacgactt tattctaggt catgaaacat ttcgttcatc 67440
tctaagaata ttacaagaca tcaagtagcc caagattttt cgtttgctcc tgattaatcc 67500
acgcacccat tttcggatcg atgtaaaaat tcattttagt ctatttgata ctattcaaat 67560
ataccctagg cacgcagtca gacgcattat gagactcttt tactgttagg ttaggtgttg 67620
ttcgatactg ggtgtctgcc aatacctcat attgcccaca gtgtcgaatt taaatcggtc 67680
aaattaggtc ctcaaagttg taacgccatc tccacattgt tgggtggtga ccggtaggtg 67740
tataataata taaggtattg aaaattgaat taaatatact ttgcgcccgt tctacatgaa 67800
ataaattcag tcgaacgatg caagaatcta cattcgaacc aagttatgag cgcgaactcc 67860
tatttaaagt ttttatcgtt caaaaacctg agagtttaac aacgttttac gtgggacatg 67920
caaacccctt accaatgtcg aaatatagga atgaacaaat ctgtcttcgt gctaagggta 67980
caattaggac gctgaagtaa tgtaacttat atgcaaggca aattataaca aaaattaaat 68040
tccagtaagg tggaagattg tgatttaaag atgactaata aatattgtta tacatcctcc 68100
taatcggttc tacggtttac gagcaccaaa atccaagacc tctaaaataa agctaagttt 68160
agacgcgtga ttatacttaa gatatcaaac tgttcgtcta ttatatccag agatattctg 68220
tatctcttat taatttatcg atctcgtata caatgactca tttatagaac tcagtataga 68280
atctaaggat cgggtgccaa tgatccttcc gatcagaaca tgaaagctat gtggtctgac 68340
gattacttct ctcaatgtct ttagaaaaaa aatcccgctg caataggatc cagtacttag 68400
taaagcaggt tgtgaatctt ataatgtttt gaagatcatt ggattttaaa aaccaaacgt 68460
ggactgatta gaaacgtaag ctaaaatcta gccacatttc taactagttt cagataaatt 68520
ataataggtt tatatggtat gcgtacccca ttctgcataa tactttaaga gaaagacaat 68580
ccaatgttga tcaagctttg aattacaaac gattatgatg taataggggt gttatggctt 68640
atattaagcc agaaattttt aggagtatca acattgccct tcggctctaa taactcacta 68700
gtggtcatcg acatgataat atattcgata atttttaact aattttattt gtatggcggg 68760
cataatatat ttagtttgag tctgcttgca acgatgttag acataagctt ggttcaatac 68820
tcgcgcttaa agaataattt caaaaacagc gagtgtttgg tgtcccaaat agttactaaa 68880
tgcaccctgt acgctagcat aacggttact actttatatc cattcttcaa tagacagaaa 68940
gaagattctc tcgttaattt tccaacttct ttacattgta tatacgttcc ctttaatttc 69000
ctattagaat taaggacatt ccatcatcta acactaaatt tctactgatt tattataaca 69060
acatgtaggt ggattaggca agacccgaaa tgctggttgt ctttggttct ggatattttt 69120
tctcgaacta tatctgcgcg ttaatatgaa ttctatagat ctacaagcag aaaagataag 69180
tcggtttaag acaatgggaa aagttagata cctagagtat taattattga gtaaatatct 69240
tctcatatat gatagattcc taccccccgg ttgctaggaa ggttagtctt gtagtttcca 69300
tagacctgac tgctaaagaa gagagtttct gatatctttt ttttagggcg acgtaatcct 69360
agatggtgat tcaaatggac caacatttag aacattacaa ttcttctagt tacctagtat 69420
ttttattttg cacctgggaa atcattgctt ttgattctag atctgtgtaa agattgatca 69480
gacttgaatt aaatttgtcc aaattatcca tgtgcatgag acaacatata ttatgaaatt 69540
cacttttcaa aaggtcacaa ctagttggag acttattgtt tgctaatatt acattatcct 69600
cacattagcg attgtagttg gctctctaaa aatcgtcata gtaccaatgg ggagccgaga 69660
ttattgagtg attaccagta gctaaactat ttaataagct attaaagatt gatcaaagta 69720
aacataccgc ctgaaatata taaatcatag tcagaccaac attgctacaa ttcgtattcg 69780
caccaacttt tgaccgcgta tttcccattt aagcttttgt tgctcacaaa acacttggta 69840
tacctatcaa tctcatggga catgcgatcg tactgtgtac gaaggtattt cggtaagaag 69900
ttatgtcact tttatctaag taagcaaata aaaagataaa aaaatgcaat atatatgcaa 69960
gggaaattaa tggacgatct taattcctgt aaggtaacac attgtgactc aaaaatcatt 70020
aaataatata attgtacatc tggctaatcc gttctgggct tttcaaccaa cagtaacgga 70080
gacttattaa aaagattttg atacggacgc gcaactattg ttaggtaact ttgaagtccg 70140
tcttttcgaa tcagccaaat tcacttacct ttttgaatct tcggatgtca taattaatag 70200
ctcgtttata gaagagtata cactatctaa gggtggaggg ccaagaatcc ttccaattac 70260
tacattaaag atatctgcac tgacgttttc tcttctcaag gacaaaagta aaaaaatgcc 70320
attgcactag gatttaccgc aaagattacc tcgttgtata tattgcagtc ttaagaacat 70380
caatggatca taaaaataaa acatgcatcc tttactatta aaatctaagt tctagacaaa 70440
ttaccaatta gtctgaactt acattaaaga gatttaatag gtacacgatc tctgtcgtat 70500
aaattacttt aactgaaatg ttttccagta ttaatcaatc cctgaatagc atacaattat 70560
aatgagacta gactataaac gttagcaacg acagagagat tattagcagc atcatagtta 70620
cctctccgct ctagtatcac acaaatggtc gtcgatcaga tagattggtc gataatctcc 70680
atgaactatc gtctgtatgg cggactttat aaatttagta tcagtctggt ttaaatgatg 70740
ttgagcatta gtgtgcttaa aaaccgtcac ataaagcgta tattcgaaaa caacgagtgt 70800
cttgtgaacc atatgcataa ttagagtact ctgtagacta gtatgacaca tggctccaca 70860
aagctattta tcgatacaat aaccattaga tactgtgggc tttgacgttg ctaaccagcc 70920
aaccatctat gtttttgaaa taaagaactc atatctttct ttaatgttct acaaatatgt 70980
ctacatcctt ttttctaggt catgaaacat ttcgttcatc tctaagaata ttacgagaca 71040
tcaaacaggt caagattttt cgtttgctcc tgattagtcc acgcacccat tttcgcttcg 71100
atgtaaaaat tcattttagt ctatttgata ctaatcaaat ataccctagg cacgcagtca 71160
gaggcattat gtgactcttt tactgttagg ttaggtgttg ttcgatactg ggtgtctgcc 71220
attacctcgt attgcccaca gtgtcgtatt taaaacggtc aaattaggct ctgaaagttg 71280
taacgccatc tgcacattgt tggctggtga ccggtagatg tataataata taaggtattg 71340
aaaattgaat taaatatact ttgcgcccgt cctacatgaa ataaatttag tggaacgatg 71400
caaaaatcta cattcgaacc aagttatgaa caggaactcg tatttaaagt ttttatcgtt 71460
caaaaaccta agtcttcaat aacgttttgc gtgggacatg caaacccctt accaatatcg 71520
taatatagga atggacaaac ttgtcttcgt ggtaagggta caattgggac gctgaagtaa 71580
tgtaacttat gaggaaggct aattataaca aaaattaaat tctagtgagg tggaagattg 71640
tgttttaaag atgactaata aatattgtta tacatgctcc taatcggttc tacggcttgc 71700
gggcaccaaa atccaagacc tctaaaataa agctgagttt agacgcgtga ttacacttaa 71760
gatatcaaac tgttcgtcta ttatatccag agatattctg tatctcctat taatttatcg 71820
atttcgcata caatgactca gacatagaac tcactataga atctgaggat caggtgccaa 71880
tgatccttcc gatcaaaaca tgaaagctat gtggtctgac gaatacttct ctcattgttt 71940
ttagataaaa aatctcgctg aaataggatc cagtacttag taaagcaagt tgagaatctt 72000
ataatgtttt gaagatcatt ggattttaaa aaccaaacgt ggactaatta gatgcgtgag 72060
caaaaatcta gctacatttc taactagttt cagataaatt atgataagtt tatatggaat 72120
gcgtacgcca ttctgcataa tactttgaga gaatgacaat ccaatgtaga tcaagctttg 72180
aattacaaac gattatgaag taatacgggt gttacggctt atatttagcc agaatttttt 72240
aggagtatca acattgccct tggggtgtaa taactcacca gtggccatcc acatgataat 72300
atattccata acttttaact aattttattt gtaaggcggg caaaatatat tttgtttgag 72360
tctgcttgct acgatcttag acataagctt ggttcaatac tcgcgcttaa agaataattt 72420
caaaaacagc gagtatttgg tgtcccaaat agttacaaaa tgcaccctgt acgctagcac 72480
aacggttact actttatatc cattcttgaa tagacagaaa caggattccc tcgttaattt 72540
tccaacttct ttacattgta tatacgttcc ctttaatttc ctattagaat taaggacatt 72600
ccatcatcta acactaaatt tctactgatt ttttataaca acatgtagga ggattaggca 72660
agatgcgaaa tgctggttgt ctttggttct ggatattttt tctcgaatta aatctgcgcg 72720
ttaatatgaa ttctatagat tgacaagcag aaaagatagg tctgtttaag acaatgggaa 72780
aagttagata cctagagtat aaattattga gtaaatatct tgactcatat gatagattcc 72840
tagcccccgg ttgctaggaa ggttagtctt gtagtttcca tagaccagac tgctaaagaa 72900
gagagtttct gatatctttt ttttagggcg acgtaatcct agatggtgat tcaaatggac 72960
caacatttag aacattacaa atcttctagt tacctaatat ttttattttg cacctgggaa 73020
atcattgctt tcgattttag atctgtgtaa agattgatca aactcgaatt aaatttatcc 73080
aaattatcca tgtgcatggg ataacatgta ttatgaaatt cacttttcga taggttacaa 73140
ctagttggag acttattgtt tgctaatact acattatcct cacattagcg aatgtagttg 73200
gctctctaaa aatcgtcata gtagtaatgg gaagccgaga ttattgagtg atcaccagta 73260
gctgtactat tttataagct attaaaaatt gattaaaata aacataccgc ctgtaatata 73320
taaatcatag tcagaccaac attgctacaa tctgtattcg caccaactta tgaccgcgta 73380
tttcccattt aagcttttgt cgctcacaaa acactaggtt tacctatcat tctcatggga 73440
catgcgatcg tactgcgtac gaagatatat cggtaagaag ttatctgtct tttttctaag 73500
tgagcaaata aaaggataaa aaaatgcaat atatatgcaa gggaaattaa tggacgatct 73560
taattcctgt aaggtaacac attgtgactc aaaaatcact aaataatata gttgtacatc 73620
tggctaatcc gttctgggct ttacaaccaa cagtaacgaa gacttattaa aaagatcttg 73680
atacggacgc gcaactatag ttaggttact ttgaagtccg tcttttcaat tcagccaaat 73740
tcacttacct ttttcaatct ttggatctca taattaatag ctcgtttata gaagagtata 73800
tactatctaa gggtggaggg ccaagaatcc ttccaattac tacattaaag atatctggac 73860
tgacgttttc tcttctcaag gactaaagaa aaaaaatccc attgcattag gatttaccac 73920
aaagattacc tggttgtata tattgcagtc ttaagaacat caatggatca taaaaataaa 73980
acgtgcatcc tttagtaata aaatctaagt tctagacaaa ttaccaatta gtctgaactt 74040
agattaaaga ggtttaatag gtacacgatc tctgtcgtat atattacttt aactgaaatg 74100
ttttccagta ttaatcaatc cctgaataac atacgattat aatgaaacta gactataaac 74160
gttaacaacg accgagagat tattagcagc atcatagtta cctctcggct ctagtatcac 74220
acaaatggtc gtcgattaga tagattgctc gataatttcc atgtactttc atttgtatgg 74280
cggactttat aaatttagta tcagtctggt ttaaacgatg ttgagcataa gtgtgcttaa 74340
aaactgtcac ataaagggta aattcgaaaa caacgagtgt cttgtgaacc atatgcataa 74400
ttagagtact ctgtaggcta gcatgacaca tgcctccaca aagctattta tcgatacaat 74460
ataaatagat atattcgcct atttttctgt ttatatccgt tatatttacg ttgtctttaa 74520
ttacctgcca gaattaaaga cattccatag tgtaggactg ggttttcagt atttcattat 74580
ataaacttga tgaccagttt ggctagtccc gacaagttgg ttgtgaatgc cctcgaataa 74640
ttcttctaaa acaatgcctg ggtgttgaca gcaatccatt gaaacttcag gcagaaaagc 74700
ctagccggtt taactgagtg gaaaaactta gaagcgttct ataatgatta tcgaggaaat 74760
atattctcat ttgtgacaga tttccacctc cggattctta gaaaggttat aggagtaatt 74820
actattgacg tgagtgcagt ggagaagaaa tcatgttttc attttatgac ggtaacgtga 74880
tcctgaatgg cgtttataat ggagtaatat atttaacgtc ggaattcttg tagttatcta 74940
gtatttatat tttgaatata ggagataata attttacatt caagaattgt ttcatgctta 75000
atcagtcttg aatgtaattt ctctaaatca tccatgtgcc aaagacagca tatttaatca 75060
aataaagttt agaaaaggtc ataattagtt acggagttat cctatgttaa tattactctg 75120
atctgatatt tgcaatcgct gctgtctctc caacattcgc cgtaatatca atagagaggc 75180
aagatcttac tatgttttcc aagggcaagt ctaactatcc agtcattaga gggactcgat 75240
agcagacgta ctgcctgaaa tatttacatg ttagtgagat taaatttact accagtcgta 75300
aacacacgat tttttagcag tttatttcgc atataagctt ttgttgctta caggacactt 75360
ggtattcgta atgatctcat gaggcgtctg ttcatactgt attccgaggc gctccgataa 75420
atagctatga tatacttatc tatattagtc gataaaaaga caaatatagc gattaaaaat 75480
gcaacaaata ttaatgaacg gtctcaaata gtgaaagata tcgctccttc ggccatctct 75540
caaaaagcca tatattcgaa ttactgatga agcccatcag ggctgttcta tctagtctta 75600
taggagttta ttttgaggtt attgttaccg accgacaacc gtcgtgtcgt aactttgaag 75660
tccgtgtttc cggatcgtct gaattggttc acctttttga atcttcgtag gattatacta 75720
atagttgctt tttgtaaaag taaacactcc ctataggtag tggtctatga gtttttgcat 75780
tatccttatt attgataatt ctactcatgt cacgtctact atagtacaaa tttattatac 75840
caccatagca ctagatctta tggagaatac tctctcatta cataaattgg agccacaggg 75900
acatgaatag atgataaata tagagattat gtcctcaatt gtaaaattgt gagttcttaa 75960
caaagtaggt attagtcaga acttacatta atgacattag gtatttgcac agtttcagtg 76020
atatagatta gttcatttca aatcttttta cgtattagtt aatgcctcaa tagagtagaa 76080
ttataataac actatattat aaacgttagc gacgacagag aggttgaaag cggcattcta 76140
gtaatctgtc cgttcgagaa caatataaaa tgttcctgta cagattgata ggttagtatt 76200
ctccctaagc tgtcctctcc ataacggact ttatagtagt acaatcgctt taatttaata 76260
catggtcagc atttttgtgc caaaaaatcg tcaaattaaa cgcatatcgg aatgcaatga 76320
atgtgctatg gaccttaagc attactagaa tagttcgcag acaactttgt cataaggctc 76380
cgcgacgcaa tttaacgata ctatatcaat aaaaataatc agctatatct ctgttaatat 76440
cgccaattct tacgttgatc aatattgctt gccggagctt atcatctttt atagggagga 76500
ggcccgtaga ggactttacg gtatataagc ccaataactt ctgccaatgg tgccgtcaaa 76560
atagatcgga gtttccagat ataaagctcc aataagaatc gctgacacaa cgcagcacag 76620
ggtcgaaact tacgcaatag tggcctaaca gactgaacca agtggaaaat ctaaggagta 76680
acccaatatg attgactgtg aataagaaat tcattcctga ggaataaccg tcaccactta 76740
ctctaaaccc taataggaat aataattatt aaaatgagga cagcgtactt aatgtcatgc 76800
tcgaataaaa tggtcctata gtgaactaga ttacctccta tgagaaagtt aagaacttaa 76860
cctggatgtc tctactcaca tgatctacct gcatgtgtaa tacacgagtc aacatattaa 76920
cacacaaaag ttctttcttc catatgcagt tatgtaagtc atagctgtat tccataaacc 76980
tatcaaagtc actatatctg gttatctaaa gtctagagaa atggatagtc atttatggta 77040
atatctcaat taagtataat tgtgataaaa tgtgtgtagt ggctcctatt ttcccgactt 77100
tcactgtgag atgattaaac aagtacacac ttgttattta ttataagctc atgtgcaact 77160
accctatcac gagaccgatc cgacaggtga agcatatata agaaactcat cacgtctgcg 77220
taattaaatt atacaccagt cgtaaaatcg tactttacta ccagtttaac atgcgtatgg 77280
tgcaacccta catacacgat acctgaaaat cgtaatggac ttagtaacag atagctaaaa 77340
cggtattccg aagcggtgca ttaattcact aaggtatgga tgttctcatt acacggctta 77400
gatacaatta tagtggcaag gaacataatt agttattacc atcggcgacg aatagtagtt 77460
tatttccttc ctgtgggctc ctcctgaaat gccacttata cggcatattg aagccgatta 77520
gtacaataga tttattcaac ctcaaaggtc tatattcccg gcttactctt agctgatatg 77580
tcgcgtcaag tctcgggatt gagtgcatta gcaccggatt gtctggctta gttcaactat 77640
tggatagctc atcgggttat actaactgac acttattctt taaataacgt tcccttatta 77700
ggactagtaa ctgagatttg aaactatcct tatttctaat catgttaact ctttcgcatg 77760
aataacagta cgagcttact ttacgagata atctcttatt caagtgcagg atactcttcc 77820
aattcttgaa gaggacgtag agtgttgaat gtattagaag ggcgtacgca ttatctgccc 77880
acttgtatat ttatgtgttt tcaaggaagg aagtatgcat caattcgttc agtatcgaca 77940
taaggtattt ggaaagtttt agtgacatag tccaatagat tcttgatctc cttaccgatc 78000
agtaaatacc attatacagt caattcagat ctacgctatt taacacataa cgccgaggat 78060
aaaagggctg aaattgacag actacaatat tgtttatgtg tcatcaatta acaataaacg 78120
aatacatgtt gatgcgatag agctctggcc aggccgtcca cttcgtatat tttctttgag 78180
tagtgtagat gtattaatat agcatgtagc cagattctta gcatgaagcg aagattaaaa 78240
tgtacgcatg ccacgttcac atatatgtgc tttagatttt tagtgttacc tgaaacatag 78300
tccatagatt ttcctttaag actacggcac gaagttaagt gatttcacac ctacaagaga 78360
aatatgccca aactatgata ataacaccgt tcgttgaatt aatcaataat gatagcggtt 78420
gcatattatc aaatgaagga gccacacccg gggagcagtt tacggtcgat atctcgtaca 78480
acttcggcta atcatgttat ctaaaaaagt tgaggtttgc agttgtcagg gcgaaatcag 78540
attcgactat atagcccagt tcagagccct aactcacgta ttcgtgacct tagagagcga 78600
gtcaagctaa ttactcattg actagctcaa tatgaggcag tgtgaataag aaatttattg 78660
caaggcaata atcctaatta ttgatagcaa actttgataa ggttgaagaa tagcacaatt 78720
cagaaagcgt tctttctgtc atactcgaat gaaatgcttt attaaagaaa aggttgatgt 78780
cctacgagat gattaagaac ttcttctgca tctcacaacc tacttaatct tcggggatga 78840
ccaaaacagt cttcgatgtc ttaatgactt atcgtccatg aatcatctat tacttccatt 78900
tcgcctgact gttcgttcaa atctgcacca ctaactacaa atattagttt aatttttatt 78960
atcctctaaa tgcgataaat tgtgtattgc ggctcctatt ttcccgactt taactgtcag 79020
atgttataac aagtacacag tagttaattg ttatttgctt atgtgcaact acgctatcac 79080
gagaccgatc cggcaggtga agcatataaa agaaactcat cacatctaca taattatatc 79140
gtacatcggt ctaagaatcg tactttgctt ctaattttac atgcgtacgg tgcaactgta 79200
tatacacgaa atctaaaaat cacaatggac tttgtatcag gtatctaaaa ggaaattctg 79260
atgccgtgct ttaattcact aaagtgtgga tgttctcttt atacggcttt gatactatta 79320
ttgtggcaag caacttaatt agttattacc atcgccaacg tataatagtt tacttcctcg 79380
gtgtgggccc ctcctcaaat gccagctata gagcatgttg aagccgatta gtacaataga 79440
ttttttcaac cccaaacgtc aacagtcccg ctttagtcta agctgatatg tcgggtcaag 79500
tctcgggatt gagtgcatta gcactggaat ctctcgctca gttcaattaa tggataactc 79560
atcgagttat actccgtcac acttattctt taaataacgt tccgttatta ggattaataa 79620
ctatcgtttg aaactattcc aatttcttat cgtgttaagt ctttcgcaag aaagacagta 79680
tgagcttact ttacgaaata atttcttttt caactgcagg atactctact aattcttgaa 79740
gaagacgtag agtgttggat gaattagaag cccctaccca ttttctatcg acttgtatat 79800
ttatctctat tcaaagatgg aagtttgcat caatttgttc agtatcgata tagggtgttt 79860
cgaaagtatt agtgacatag ccctatagat tcttcattac caaaccgaac actagttagt 79920
attaaacagt caattctgtt ctacgccatt taacacataa cgctcaagat aacagagctg 79980
aatttgagag actacaatat tgtttatgtg tcaccaatta acagttaacg aatacatgac 80040
gatgcggaac acctcgggcc aggccgcgca cttcctatat ttactttgag cagtgtaggt 80100
gtaataatat agcatgtagc ctcatgctta acttgaaccg gagataaaaa tctatgcacg 80160
cgaccttcac atttacaagg tttagatttt taatgctacc caaaacaaag tccataggtt 80220
tttcattaag actacggcgc aaagttaagt gatttcactc ctacaacaga aatatgccca 80280
aactatgaaa acaacatggt tcgtagaaat aatcaatcgt gatagaggtt gcatattgtc 80340
aaatcaaaga gccacactcg gggagcagtt gacggacgtc atcacgtgca atttcggcta 80400
atcttataat ctataaatgt tgaggtttgc agttgtcagg gcgagatcaa attcaagtat 80460
atagtcctgt ccagagcctt aattcacata ttcgcgacgc ttgaaagcgc gtcatgctta 80520
tcactgattc actagctcaa tgtgtggcaa tctaagtagg aagtctgttg caaggctaaa 80580
aaactaaata ttgatagcta ccttagttaa ggtagaagaa ttgcacaatt cagtaggcgt 80640
tttttctgct atactcgaac ggaatgcttt attaaagtaa agcttgatgt cccacgagat 80700
gaacgagaac ttctataaca tctcacaacc tactaaattt tgggggatgg gtaaaagtta 80760
gctgaacata caaataggaa tttgattgta cccttagacg aaactaaaca aatcatagta 80820
aatccgcaca aagtttacat attaattcat acggcgtttc aaagaggcaa tggcttgact 80880
tgtggtgaat tacagtttgt gagtaaccac aagatgcggt aaatactgta atccgagttt 80940
aattgactcg acttaaagat tctgatatta taatgaaaac acaatggttt attgtcaatt 81000
acttatgcac tgttacatct tgtggtcctc ggtccagcct gcgtaggata taaatgaagc 81060
acgtctcatc cagattgatc tatcgtacct ccaaatacga attcaacttg gcgtctatat 81120
ccagaaatga gccctagaag tgatagactt ccaaatcttt aaactaccat gggatatgtt 81180
tcacgtatcc aaaaagtaat tataattctg cgtttccatt cacttaagtg aggatgtagc 81240
ctttatattg gtttcatagt tttgttatac caagcatgta ttttacctag cactattttc 81300
aacctaaaac tgttttgttt ctcgatgtca aacccttgtc agctacctgc ggtggtgcac 81360
gaaaaaaccg attagaatat taaatattta caactccaaa ttttaagagc cctgctctag 81420
tttaaattca tatatcagta taggcttcgc aatttagtga ataagcggta tgaattttcg 81480
cggagtatga aaagtgacta agtaatcgag atacataccg ttagatagat gcttcagact 81540
gcattctgaa tttttgattt ataaccatcg aaggaatcaa tttcatgttc ctaacgtgtt 81600
aagtcatcag taaaaaagac cataagggct ccccttttga aataatactg tttcaaacta 81660
taggctgccc tacttggtgt tcaagatact atagagtctt cgatgattta aagcccccaa 81720
cccatgttca atcaacttct atgtttaacc ttaaactaac acaggaacca gctaagattt 81780
gtttagcatc atttgggcac gttacatata taaaataaag tatgccgcag agtttctccc 81840
ttaccgaact gtagtcgacc taaagtctaa tactcattgg tgttgtatca cttttgtgac 81900
attaggtatg atttaactct tgaaaatttt tacgactatg ataaaagatt agagctacca 81960
aataactgtt aataatcatg tcactatgta gatcgccaag aatcagctgg gatgaatgca 82020
ttatttacat cgtgcaaact aggtctgagt aggtaccatc gtagtttatg cctaagttga 82080
accgcaaata taggtctttt gccgggatct ccactatctg taaattgtga aacctgttgg 82140
taacctatac aaaatacata gctatatcat tagtaataaa acgtaaacga aagatcattc 82200
actccttctt cggaaagata accaaagaat taggagaata tggtgcgcac atagaaagga 82260
tcgggaaata actttgacct tcacagaaca ataagttaca atttgggaac agtcggataa 82320
cgccactacg tgcttatttg gtttacctta aattttataa ttgatgagga ttaaaattca 82380
cgggagaaga tctaacataa gtatatagtt atatctgaag cgtttgaaca cttactccct 82440
ttacttaatt aggccttatt gttttccctg actcataagt tctatgattg gcaatctatc 82500
tacaaggaga cacgtatcat ttaaaaacaa aaaattggta acttccttag ttaaagtgct 82560
gggaatgctc aaatcagtag tcttcttctc tggaaatcgc gaggggggaa ttttatcatg 82620
tcgaagtttg ttattggact cattcaacca taggctccat gatattaaaa gagctagtaa 82680
actacggggg taggatacaa atttcttgat aatagaaatc ggaattcgaa tgtgtccttg 82740
gtcgactcag atccaatcca agtgaaccca acgaatgtat atattttatt acatatggcg 82800
tcttaaacag ggaatccctt aacatcaact ggttttcaga taataagtaa ccgcaacata 82860
gtgaaaacac agttatcgat actagttaga gaacctttaa taatgctaca accattttct 82920
aatcttgatg atttgttgac aattattagt tcagcgagcc atctaacggt tcttagtcaa 82980
ctctacttat gcaataaatc ttgcatgttt gacgctaact caaccatggt agcatcaaat 83040
acggatacaa ttaggggtta atatgcagaa aatgggctta gggatgatag acactttaca 83100
aattgcacaa gcaatcgaaa tgttttatgt atcgatatag tatgcatttt tatagaattg 83160
ccttctagca tgacagaaac aagcctatct attcgtttct ttatcctcct ataccacgtg 83220
tgtacctttc ccggccattc attaagaccg gaagtatctt gttatacaat attaaacctt 83280
taacagccta tcgcgctgat acacgaatta accaaatgaa gtttaaaaaa ttaactactg 83340
ttatttttaa gtggcttctt caagattgca ttcatatatc aataatgact tactaaggtt 83400
ctaaatgaga gaattcaatt aatctggata aacaaaaggg tctgaagatt cataatacca 83460
accattaaat agacgttcct ctgtgtatag taaatcttta ttttttaacc tttgaagaaa 83520
tcgacaacac gacccttgcg agtatagtta tgaaaagaag agatcttcat ctttgccccc 83580
ttataatagt acagcttcaa acaatattct cagtaagatg gtatgtgtgg tactaagact 83640
ttcatgacta tttgatgtcc ttattctatg tataaagagt aataatctta agtctggagt 83700
ttactcagca accagttgag tctaggcaca gctttcttgg gttgcttata tattgaaaat 83760
aatgtactca acaggatcag tctcataagg aattgtgatt gaccaaaagt ccgctatgca 83820
ttgacgtcgt ctcagtttag tacctataac tatcatcatt cttttggtgg ctattacaat 83880
gttggtaaaa gaataaaact acaacacatc tgttaataat caactcgctc gattgattgt 83940
caagaatgtt tagtgatgag tatgttattt aaggcactcg agttgtgatt gagttggatc 84000
cattgtagtt tacggctata taagtcctca ataatacgct ctatacgcaa attcctatta 84060
tctgtgaaat gtttaacgcg tacgctaact ctataaaata cttaactata ttatacgtta 84120
gaatatctta acggacaatc gcattgtatt tatttgtata gattaatgaa aaagtaggtg 84180
cgaatattgt aggtatggta aaggccggta agtaattcta gccttcatgg aacgttatgt 84240
tttaatttga aatttaaggg atagtgcgtc taaatcgtta ataaaattag ttgaaatcac 84300
ctagttagaa tctgtaaaaa ttcaccataa aagttccacc gtaaattaat gattactact 84360
gtataattcc aaaatttact ctcttaagtt aattaaacca atctgtttcc ctaggcttct 84420
ataaaatagc gtcggtaatt ttcccgcatg gagacagatg ttattcggaa ataaaaattt 84480
acaaacttct ttggcacttc tgctgacaac agttttgttt atactattct tgtcatgatg 84540
tagatacgac gcgttattat catgtcgaag ttcataataa gtgtcatttt accatacaga 84600
ccatgattct gaaagtactg acaagctgca aatatgaaat tcatatttct catcacaagg 84660
ctacagacct ctaataagat gtacgttaac tgagattcgt gtcggtagaa ccgaacgatc 84720
atgtaacttt cactatatga gttgacctgc tttgagcttt cctttatact aactggtatt 84780
ctggcgaaac aaagctgtag cagaatcatg tcatgagtat taatagtagt aagaaaatca 84840
cggataatgt tacaaccgtt ttcttattta gaggtagtgt gaagaacttt tacatgaacc 84900
agcaaactaa catctctttc aaattactac tcatacaata agttccgtga cgacatgact 84960
atctcaacct gatttacaat taatgctctt atattgagaa gttattaagc gagatatgca 85020
tttaaggata atagacacat cacaaattgc ggataccatt gagacatttt ataaatagat 85080
gcaatatgga atcttataga attgcctgat agcgttatat tgatgaacat gactaattac 85140
cctttcaccc acgctattag cttccatacc atttgcggcc attcattaag atccgttgtt 85200
ccttacaaaa aaaaaattaa taagaaattc cgtaacatgc agatttagta gttattataa 85260
acaactttac tggaacaaac taaaacattt ataaacagaa ttttgatagt ggcaattaat 85320
ttctaatgat gtgatattaa ggtctaaaat gtaagaattc gataaattag attagacaag 85380
gggatccgaa gatattttag cgcagttagt tataggggga acctctgcct acaaaaagcg 85440
tttattgtta attgtttaaa gatacagtga aaacgacagt cgttaaaaca aaaatgatat 85500
gtacaatact acatctaagc agcgcaataa cgcaacagct tgaagtattt ttcacagaaa 85560
aatcgtacgt ccagttctaa cactttcata tgtgttcgtc gtttatgctt ttagtatgaa 85620
aactagtgtg ccggtgtctg gagatcatcc ttcttgcata tgactccaag gacagccatc 85680
atggtttgta agttcattga gactgttacg cttaactgga cgaaactcga gaagatatat 85740
gattgatcgt aagaccgctt tgattcgaca ccatcataac acagtactca tgattatcat 85800
cattttttta gtccctatta caaagctgcc aagtgaataa atctctatca cactctatga 85860
aaatgcactt gatcgtttta ttgtagaaaa aatttaataa acagaatgtt aatgaaggca 85920
ctactgtact aatagagttg ggctatatgt taactacaag actataactt attaataact 85980
cggtctatac ataatttggt atcatgtatg tagtgttcaa gggctatagc aattctgata 86040
aaaatttatt aaggtaacac cttagaataa tatactggtc tatcgcaata caaccacttc 86100
taccgtataa tccgagagtg gccacgataa tcgaaggtat ggtcaaccgt tgtaagtaat 86160
tctaggcgat aaggaatcct ttttttataa attttcttta ggacattgtt cacgtaaatt 86220
atcaagatta attgttgtaa tgagctcgtt tgattttgaa aatttgtgtc ttaaattcgt 86280
ctccgattaa tacactatac tatactttaa tcccagatat atcaatatta aactatttaa 86340
tttaatctaa tcctcaaacc ttctattaaa tcgtgtcaat caatatctgc ttcctaaatg 86400
gaagtttttc gccaaaaaca ataaacagaa tttaaagtcg cttttgtcct cagcaatttt 86460
gtttttttta tacaggttat aacgtagatt cattccgtta aagcgttgtc caattggata 86520
aaaaacatct ttttaatctc caggtcaagt ttgtgaaagt aaacacgtcg agcaaatacg 86580
tataccgcac atttgaccac gcagccacat acctctggaa ggaaaaacac atactaacct 86640
acctgacgct agtgcaaaac attcaagaaa ctctgacaat gcgaattaac gagccttaaa 86700
ctcttttatt tgctgataag cattattgcg aaactagctt gagcttgtat tgtctggtgt 86760
gtactattag aagtgaaaaa atcagggtta atgtctcgtc gcctcattta tatacagata 86820
gtcagtgata cctaaacgta tactagcaaa atgacatctt aattaaatta tttatcttac 86880
atattcttcc tagatgacat gaatatgttg gtccgatgta taattgatgt tctgatatag 86940
gataataact gaaacacata tgtattatac caaagtatgt acatcacaag ttcccaatat 87000
cgtttagact actatttact aatcccattg tggaatctta atatatgatc ggatagcctt 87060
gtgttcgtga aaacggcata ttaggctcac agcggtgcta ttaccttcca taccagctag 87120
caacaacgat aatcatccgc tattggatag gaaaatagta tttaaaagaa atcttgtaac 87180
aaatgtttta tatagtccta attaactaca ttactcgagc gaactaaaac ttatgatcac 87240
aaaaataaag ctgagcctaa ttatgtgata tgatttaaaa tttcggtcta tatagttata 87300
atttgatgaa ataaattgga ttagcagttt gctagatgat ttggcacaga tagtcataga 87360
cgaaggactt actatgaaat agcggtttta gttgtcaatg ttggatttca gcgaaagcag 87420
gaatcgatgt agctaaagaa atatgtccat cattgcattt agataaggca tcttgccaaa 87480
aagagaacca atattttgta aagaaactag aggtcctctt tatactctat gatttgtgca 87540
gctcttaaat gcaaacgacg agtaaacagg tgcgtgggtg tatggagacc ttcattttta 87600
tgtatgattg gatggactac gatcacattt tatgggttct ctgcgactgt cacgctaaat 87660
tactcggaaa ttgacaatgt aatcgactac ttgtaataac ccactgatcg aactggagca 87720
taacgggtca cacatcataa ttttcactat tttagtccga attattcagc atcgcagtaa 87780
atgtataaca atcggccact gtccatttac atatcatcgt attccattag aattaattta 87840
atatatagaa tgtgtaagta ggatctactg tacttatatg accatgctac atattaacat 87900
gaaaactata tccaattctt gaccttgtgt atatataata tgaatacgaa catgttggat 87960
tcaaaagtta tagcaaatcc catcttaaat gtttagggaa aggctttagt attatattct 88020
agcctattgg aacacaagca cctttcccat gtaaacccag tgtcttcacc ataatgaata 88080
ctttcatcga tcgttattgc ttttagtaca tgatgactcg tccttttaac ataaattttc 88140
tactgaatat tcattacaaa atgtaccagg attaaccaat gtaatgagcc cccttgattt 88200
tgggtactgg tgattttatt tcgactcaga tttacacact aaagtaaatt ttaaagctag 88260
acatacaaat attaaagctc tctatttaac ctaaacgata aacaatcagc taaaccgtgt 88320
cttactgagt ctgcttcttg aatgatactt taccgccaaa gtcaacagtt actacctaaa 88380
gtcgctttga tcttttgcta caccgaattc tttatgaaga gagtaacgta aatctatttt 88440
gtagaacgat ttttttctag gtcatgaaac atttcgttca tctctaagaa aattatgaga 88500
cattaaacag gtcaagaatt ttcgtttgct cctcattagt ccacgcaccc attttcgttt 88560
cgatgtaaaa attcatatta gtctatctga tgctaatcta atatacccta gacacgctga 88620
cagagccatt atgtgagcct tttactgtta ggttaggtgt tgttcgatac tgggtgacta 88680
gcattacctc gtattgccca gagtgtggta tttaaaatgg tcaaattagg ctctaaaagt 88740
tgtaacgcca tctgcacatt gttggctggt gaccggtaga tgtataataa tataaggtat 88800
tcaaaattga attaaatatg ctttgcgctc atcctacatg agataaatat agtggaacga 88860
tgcataattc tacattcgat tcaggttatg aacaggaact cgtatttaaa gtttttatcg 88920
ttcaaaaacc taagtcttca ataacgtttt gggtgggatt tgcaaacccc ttaccaaaat 88980
cgtaatatag gattggataa acttgtcttc gtggtaaggg tacaattggg acgctgaagt 89040
agtgtaactt atgagaaagg ctaattataa caaaaattaa attctagtga ggtggaagat 89100
tgtattttaa agatgactaa taaatattgt tatacatgct cctaatcggt tctacggctc 89160
gcgggcacca aaacccatga cctctaaaat aaagctgagt ttagacgcgt gatttcattt 89220
aaaatttcaa tctgtttgtc tattatatcc agagatatac tgcatctcct attagtttat 89280
cgatttcgca tacaatgact cagacaaaga actcactatg gaatccgaga atcaggtgcc 89340
aatgatcgtt ccgatcaaaa catgaaagct atgtggcctg acgaatactt ctctcattgt 89400
ttttagataa aagatcttgc tgaaatagga tccagtactt tgtaaagcaa gttgagaatc 89460
ttataatgtt ttgaagatca tcgggttcta aaaaccaaac gtggactaat taggtgcgtg 89520
ggtaaaaatc tagctacatt tctaagtagt ttcagataaa ttatgataag tttatatggg 89580
atgcgtacgc cagtctgcat aatactttga gagaatgaca atccaatcta gatcaagcta 89640
tgaattacaa acggttatga agtaaaacgg gtgttacagc ttaaatttag ccagaataat 89700
ttaggagttt caacattgcc gtagaggtgt aacaactcac cagtggccat ccacatatta 89760
atatattcca taacttttaa ctaattttat ttgtaacgcg ggcaaaatat attttgttta 89820
agtctgcttg ctacgatctt agacataagc ttggttcaat actcgcgctt aaagaaaaat 89880
ttcaaaaaca gcaagttttt ggactctcaa attgttacaa aatgcaccct gtacgttagg 89940
ggaatggtta ctactttata tccattcttg tttagacaga agcacgattc ccatgttaat 90000
cctccaactt cattacattg aatatacgtt ccctttaatt ttctatttga tttaaggtca 90060
ttccatcatc taacactaaa tttctactga ttatttataa caatatgtag gaggattagg 90120
caagatgcga aatgctggtt gtttttggtt ctggacattt tatctcgaat taaatctgcg 90180
cattaatatg aattctatag attgacaagc agaaaacata ggtctcttta agacaatggg 90240
aataattaaa tacctagagc ataaattact gagtaaatat cttgactcat atcatagatt 90300
cctagccccc ggttgctagg aaggttagtc ttgtagtttc catagaccag actgctaaag 90360
aagagagtta ctgatatctt ttttttaggg cgacgtaatc ctagatgatg attcatatgg 90420
accaacactt agaatattac aaatcttcta gttacctaat atttttgatt tgcacctggg 90480
aaatcattgc attcgatttt agatcggtgt aaagattgat caaactccat ttaattttat 90540
ccaaatttac catatgcatg ggataacacg tattatgaaa ttcacttttc gttaggttac 90600
aactagttcg agacttattg tttgctaata ctacattatc ctcacattag cgaatgtaat 90660
tggctctcta aaaatcctca tagttgtaat gggaagccga gattattgag tgatcaccag 90720
tagctgtact attttataag ctattaaaaa ttgattaaaa taaacatacc gcctgtaata 90780
tataaatcat agtcagacga acattgctac aatctgtatt cgtaccaagt tatgagcgcg 90840
tatttcttat ttaagttttt gtcgctcaca aaacactggg tttaccaatc attcacatgg 90900
gacatgcgat cgtactgcct atgatgatat attggtaaga agttatctgt ctttcttcta 90960
agagagcaat taaaaggtta aagaaatgca atatatatgc aagggaaatt aatggataat 91020
cttaattcct gtaaggtagc acattgtgac ttaaaaatga ctaaataata ttgttgtaca 91080
tctagctaat ccgttctggg ctttacgacc aacagtaacg aagacctatt aaaaagacct 91140
tgatatggac gcgcaactat agttaagtta cctagatgtc cgtcttttct attcagccaa 91200
attctcttac ctttttcaat ctttggatct cataattaat agctcgttta tagaagagta 91260
tatactatct aagggtggag ggccaaggat ccttccaatc acaacatcaa agatatctgg 91320
actgacgttt tctcctctca aggactatag aaaaaaaatc ccattgcatt aggatctacc 91380
acaaagatta cctggttgta aattttgcaa tgttaagaac atcaatggat cataaaaata 91440
aaacgtgcat cctttagtaa caaaatctaa gatctagaca aatttccaac tagtctgaac 91500
ttagattaaa gaggtttaat aggtacacga actctgtcgt atatattact ttaagtgaaa 91560
tgttttccag tgttgatcaa tctctgaata acaaacgatt ataatgaaat tagagtgtaa 91620
acgttaacaa cgaccgagag atttttagca gcatcatagt tacctctcgg ctctagtatc 91680
tcacaaatgg tcatcgattt gataaattgc tcgataattt ctatgtactt tcatttgtat 91740
ggcggacttt ataaatttag tatcagtctg gtttaaacga tgttgagcat aagtgtgctt 91800
gaaaactgcc acataaaggg taaattcgaa aacaacgagt gttttgtgaa ccatatgcat 91860
aattagagta ccctgtacgc tagcatgaca catgcctcca caaagctatt cttcaataca 91920
gtataaatag attcattcgt ctatttttct atttatatgc gttatattta cgttgtcttt 91980
aattacctgc tagaattaaa gacattccat tgtgtaggac tgagttttca gtaattcatt 92040
atattaactt gaagaccaat taggcaagac ccgacaagtt ggttgtgaat gcctccgaat 92100
aattcttcta aaactatgcc tgggtgttga cagcaatcca ttgaaacttc aggcagaaaa 92160
gcttagccgg tttaagtgaa tggaaaaact tagaagcgtt ctgtattgat tatcgaggaa 92220
atattttctc atttgtgaca gatttccacc tcccggttct taggaaggtt aaaggtgtaa 92280
ttactattga cgtgactgca gaggagaaga gatcttgttt tcatttttta acggtaacgt 92340
gatcctgaat ggcgtttata atggagcaat atatttaacg tcggaattct tgtagttatc 92400
tagtattttt attttgtata taggagataa taattttaca ttcaagattt gtttcatgct 92460
taatcagtct tgaatgtaat ttctctaaat catccatgtg ccagagacag catatttaat 92520
gaaataaact ttacaaaagg tcataattag ttagggagtt atcgtatgtt aatattactc 92580
tgatctgata tttgcaatcg ctgctgtctc tccaatattc gccgtaatat caatagagag 92640
gcgagatcat actgtgtttt ccaacggcaa gtctatctaa ccagttatta gaggaacttg 92700
atagcagaca taccgcctga aatatttaca tcttagtcag attaaattta ctacgactcg 92760
taaacacacg attttttggc agtgtatttc gcatataagc ttttgttgct tacaggacac 92820
ttggtatacg taatgatctc atgagacatc tgttcatact gtgtaccgag gtgttccgat 92880
aaatagctat gttatattta tctatataag ccgataaaaa gacaaatata ggcattaaaa 92940
atgcaacaaa tattaatgaa cggtctcaat tagtgaaagg tatcgctcct tggcccatat 93000
ctcaaaaagc gatatattcg aactactgat gaagcccatc agggctgttc tatctagact 93060
tacgggagct tattttgagg tttttgttac ggaccgacaa ccgtcgtgac gtaactttga 93120
agtccgtctt tccggatcga ccgaattggt tcaccttttt gaatcttcgt aggattatac 93180
taatagttgc tttttgtaaa agtaaacact ccctataggt ggtggtctat gagtttttcc 93240
attatcctta ttattgataa ttctactcat gtcacctcta ctatagtaca aatttattat 93300
actaccattg cactagatct tacggcgaat actctctcat tacataaatt ggagcctcag 93360
ggacatcaat agatgataaa tataaagttt atgtcctcaa ttgtaaaatt gtaagttctt 93420
aacaaagtac gtattagtca gaacttacat taatgacatt aggtatttac acagtttctg 93480
tgatatagat tagttcattt caaatctttt tccgtattag ttaatgcctc aatagaatag 93540
aattataata acactatatt ataaacgtta gcgacgacag agaggttgaa agcggcattc 93600
tagtaatctg tccgttcgag aacgatataa aatgttcccg tacagattga taggttagta 93660
ttctccctga gctgtcgtct ccatgacgga ctttatagta gtacaatcgc tttaatttaa 93720
tacatggtca gcatttctgt gccaaaaaat cgtcaaataa agcgtatatc cgaatacaat 93780
gaatgtgcta tggaccataa gcattactag aatactccgc agacaactat gtcataaggc 93840
tccgcgacgc aatttaacga tactatatca ataaaaataa tcagctattt ttctgtttat 93900
atcgctaatt cttacgttga ttaatattgc ttgccggagt ttatcatctt ttatagggag 93960
gaggcccgta gaggatttta cggtatataa gcctaataac ttctaccaat ggtgccgtca 94020
aaatagatca gagtatccag aaataaaact ccaataagaa tggctgacac taggcagcac 94080
aggatcgaaa cttacgctac aaaggcctaa cagactgaac caagtggaaa aactaagaag 94140
tatcccaata tgattaactg tgaataagat attcattcgt gaggaatatc cgtcaccact 94200
tactcaaaac cgtaatagga ataataacta ttaaaatgag gacagcgtac ataatgtcat 94260
gctcgaataa tatggtcgta tggtgaacta gaatacctcc tatgagaaag ttaagaactt 94320
aacctgggtg tctctgttca tatcttctat ttgcatctgt aatacaggag tcaacatatt 94380
aacacacaag agttctttct tccatatgca gttatgtaag tcattgctgt attccataaa 94440
cctgtcaaag tcactatatc tggttatgta aagtctagag aaatgcatag tcatttatgg 94500
aaatatctca actaagtata attgtgataa aatgtatgta gtggctgctg tttttccaac 94560
tttcaccgtg agatgattaa acaagtacac tcttgttatt tattataagc tcatgtgtaa 94620
ctaccctatc acaagagcga tccgacaggt gaagcattaa caggaaactc atcacgtcag 94680
cgtaattaaa ttatacacca gtcgtaaaat cgcactttat tagcagttta acatgcgtat 94740
agtctaaccc tacatacacg atacctgaaa atcgtaatga acttagtaac ggatagttaa 94800
aacggtattc cgaagcggtg cattaattcg ctaaggtatg gttgttctta ttacacggct 94860
tagatacaat tatagtggca aggaatacaa ttagttatta ccaacggcga cgaatagtag 94920
tttatttcct tcctgcgggc tcctcctgaa atgccactta tacggcttat tgaagccgat 94980
tagtacaata gatttattca acctcaaagg tctatattcc cggcttattc ttagctgata 95040
tgtcgcgtcg agtcccgggt ttgagtgcgt taacaccgga ttgtctggct tagttcaact 95100
tttggatacc tcatcgggtt atactaactg acacttattc tttaaataag gttcccttat 95160
tgggactagt aactgagatt tgaaattatc cttatttcta atgatcttaa ctctttcgca 95220
tgaataacag tacgagctta ctttacgagg ttatcactta ttcaagtgca ggatactctt 95280
ccaattcttg aaaaggacgt agagagttga atgtattaga tgggcgtacg cattatgtgc 95340
tcacttgtat aattgtgtgt tttcaaggaa ggaagtatgc atcaattcgt tcagtatcga 95400
cataaggtat ttggaaagtt ttagtgacat agtccaatag atttttgatc tctttaccga 95460
tcagtaaata ccattataga gtcaattcag atttacgcta tttaacacac aacgccgagg 95520
ataaaagggc tgaaattgac agtctacaat attgttcatg tgtcaacaat taacaataaa 95580
cgaatacacg ttgatgcgat agtgctctgg ctaggccgtc cacttcgtat attttctttg 95640
agtagtgtag acgtattaat atagcatgta gccagattct tagcatgaaa cgatgattaa 95700
aatgtacgca taccacgttg agatgtatgt gctatagact tttagtgtta cctgaaacat 95760
agtccatcga ttttgccata agactacggc acgaaattaa gtgatttcac acctacaaga 95820
gaaatgtgcc gaatctatga taataacacc gttcgttgaa ttaatcaata atggtagcgg 95880
ttgcatatta tcaaatgaag gagccacacc cggggaggag tttacggtcg atatcccgta 95940
caacttcggc taatcatgtt atctaaataa gttggggttt gcagttgtca gggcgaaatc 96000
agattcgact atacagccca gttcagagcc ctaactcacg taatcgtgac cttacagagc 96060
gagtcaagtt aattacctat cgagtagctc aatatgagag agtgtgaata agaaatttat 96120
tgcaaggcaa taatcctaat tattgatagc aaactttgat aagaataaag aatagcacaa 96180
ttcagaaagc gtacttactg tcatactcga atgaaatgct ttattaaaga aaaagttgac 96240
gtcctatgag aagattaaga acttctcctg catctcacaa cctacttaat cttcggggat 96300
gggtaataga taggtgaaca tataaataga gataagtttc taccttcaaa cgtagttaaa 96360
caagtcatag ctatatccca caaacctttc ataatcactg tatcgggata tctaagaagt 96420
aatggtatgg ctagtgatca atcataattt gtcagttaag acaagatgcg gtaaattgtg 96480
tattgcgagt cctattgtct cgacttaaac tgtctgatgt tataacaaat acacagtagt 96540
taattgtcaa ttgcttatgt actgctacgc cttgtggaga ccggtccggc gcgtgaagga 96600
tataaatgaa actcgtcaca tccacattat tatatcgtac atcggagtac gaatcgaact 96660
tggcctctat ttttagatgc gtgcgctgca agtgtaaatg taccaaatct aaaaattacg 96720
atgggttttg tttcaggtat ccaaaaagta attctgatgc cgcgcttcaa ttcactaaag 96780
tgaggatgtt gtctttatac gggtttgata cttttattgt accaagcatc tttattagtt 96840
agcactatcc ccaacgtata acagtttact ttctcggtgt gagcccctcg tcaactgcct 96900
gcagtagtgc acgttgaagc cgattagaat attagatttt ttcaactcca aacgtcaaca 96960
gtcccgctct agtttaagtt catatatcag gacaggtctc ggaattaagt gtataagcgc 97020
tgggaacttt cgcgcagttc gaatagtgag taagtgatcg agttacacac cgttagattc 97080
atccttcaga taacgttccg tttttttgat ttataactat cgtttgaatc aattccatct 97140
tcttaacgtg ttaagtcatc cgcaaaaaag acgatatgag cttaccttac gaaataattt 97200
catttcgaac tacagggtgc tctacttgct cttgaagata tcgtagagtg ttggatgaat 97260
taaaaccccc tacccatttt caatcgactt gtatgtttat ccttaaacta acatggaaat 97320
ttgctttgat ttgtttagta tcatttaggc gtgtttcaaa tgtataatta agtatgccgc 97380
atagtttctc cattaccgaa ctgaacacca cttagtgtca aacactcatt gctgttctac 97440
gccatttatg acattacgct caaattaact gagctgaatt tcaaagacta taatattatt 97500
tttgtgttac caattaacag ttaacgaata cgtgacgatg tagaacacca ggagccaggt 97560
cggacgcatc ctatatttac ttcgtgcaga gtaggtctaa caagatagca tggaggttta 97620
tgcttaagtt gaaccgcaga taaaggtcta tactcgggat cttcactatc tgaaggttta 97680
gaattttaat ggtaccctat acaaagtgca taggtttttc attaatatta agacgcaaag 97740
gtaagtgaat tcactcctac aacggaaata tgaccaaagt atcaaaacaa tatggttcgt 97800
agaaaaaatc gatcgtgata aaggttggat tttgacaaaa caaagagcta cagtctggga 97860
acagtcgatg gacgccacca cgtgcttttt cggctaatct tataatttat aaatgttgag 97920
gtttagaatt ctcgggacga gatcaaattt aagtatatag tcatatccga agcgttaaat 97980
cacttattcg ccatgcttaa aagcgcctca tgcttttcac tgattcatta gctctatgta 98040
tggcaatcta tgtacgaagt ctgtcgtaag acttaaaaac taaatattgg tagcttcctt 98100
agttaaagta caaggattgc acaattcagt agacattttt tctggtattc ccgaacggaa 98160
agctttatta agacaaagtt tgatatccga cgggatgaac cacaagttct atgatatctc 98220
agaagctact aaatttcggg ggttgggtac aagttagttg aacatacaaa ttggaatttg 98280
attgtatcct tggtcgattc taaacaaatc gtagtaaacc cgtgcaaagt atatatatta 98340
tttcatacgg cgtttcaaag aggcaatggc ttgacatgag ctggatttca gattatgagt 98400
aaccacaaga tagtgtaaac actgtaatcc atatttaatt gagatctctt aaaaatgctg 98460
atattatttt ctaaactcga tggtttattg acaattattt gtacagtgat acatctagcg 98520
gttcttggtc gaccctactt acgtaataaa tgtagcacgt ttgatccaga ctcatccatg 98580
gtagcttcaa atacggattc aacttggcgt ttatatccag aaaacggccc tagaggtgat 98640
agacatttaa cactttggac aaccattgga tatgtttcac gtatcgatat agtaattatt 98700
attctgcatt tgctttctag taagtgagga agaagccttt ctattggttt cttaatcctc 98760
ttataccacg cgtgtatctt tcctagccct ttattgaaac tggaagtgtc ttgttattca 98820
atgttaaacc cttgtcagcc tattgcggtg atgcacgaaa aaaccaaatg gaatataaaa 98880
tattaactac tcctaatttt aagtgccctc ttctagattg tattcatata tcaatataga 98940
cttcgcaaac tagtgaatga gggaaatgaa tttatccgga ataacaaaag ggactgagta 99000
ttcaagatac aaaccgttag atagatgttc cagtctgcat agtaaatttt tgttttttaa 99060
ccattgaagg aatcaatttc acgatcctta cgagtttagt catcagaaaa agagaccttt 99120
agcgctcccc ccttgaaata gtacagcttc aaacaataac ctgagtaagt tggtatccga 99180
ggtactataa atttttcgat catttgatgc ccccatccta tgtttaaaga actattatct 99240
ttagccttaa gcttacacag gaaccagctg agtctaggtt aggttcactt gggttgctta 99300
catatataaa ataatgtata ccgcagaatt tgtcccttag ggaattgtag ttgaccaaaa 99360
gtctattact cattggcgtt gtatcacttt tgtgtcaata ggtatgatca atctcttgga 99420
aattattacg atgttggtaa aagattagaa ctactaaaca actgttaata atcaagtcgc 99480
tccgtagatt gccaagaatc agttgagatg aatacgttat ttagaacgta caaactacga 99540
ttgagttggt accatcgtag tttatgccta tgttaatccc caattatacg tcttttgccc 99600
gaatccccac tatctgtgaa atgtttaacg tgttcgttac ctttacaaaa tacatagcta 99660
tatcatacgt aaaaatatct taacggaaga tcgtacactc tttcttcgga tagataagca 99720
aagaaatagg aggatatggt gcacacatgg aaagggccgg taagtaattc tggccttcat 99780
agaacaatat gttataattt ggaaattgtc ggatagcgcg actatgtgct taattggttt 99840
actttaaatt ttataattga tgacaataaa aattcaccgg agaagttcta acgtaagtat 99900
atagttataa ctgaacgatt ccaagattta ctcccttaag ttaattagac ctatttgttt 99960
tccctgactc ctaagtttta tggttggcaa tttatctgca aggagacaca tatcatttag 100020
aaataaaaaa ttggaaactt ctttagctgt tgtgctggga acgctcatat caatactttt 100080
cttctctaga agttgaaagg ggggaatatt atcatgtcga agtttgttat aagagtcatt 100140
ctaccataca caccatgatt ctgaaagtgc tggtaaacta cgggaataag atacatattt 100200
ctcattatta gaattcagac ctcaaatgag tcgttggtca actcagatcc gaatcgaaag 100260
aacccaacga atatataact tttattacat gtgttgtctt agtcagagta ttccttaaca 100320
ttaactggtt ttcagacgat atgtaactgc agcagagtca aatcatggat attgatagta 100380
gttagagaac cattgataat gttacaacca ttttctaatt ttgatgttgt gtagacaatt 100440
attagttgag cgagctaact aacagttctt acaaatctct actcatacaa taaattccgt 100500
gagctcaaca ctaactcaac ctaggtaaca tcaaatgccg atatattcag gggttattat 100560
gcgagatatg cgcttaggga taatagacac tttacaaatt gcgcatgcga tcgagatatt 100620
ttatgaatcg atataatatg cattcttata gaattgcctg ttagcgtaac ataaataaac 100680
gtatctaatt acttttttat ccacgcttat tacatccgta ccatttccgg ccattcatta 100740
agatcggaag taccttgcaa tacaaaatta aactttaaat accctatcac gcagatttag 100800
caattatttt aatcaacttt agtggatcaa tcatagacat ttttaagtgg tattttcaag 100860
gtggcattta aatattaatg atgacatatt aaggttttaa atgagagaat tcaattaatt 100920
tggttagaca aagggatccg aagatatttt atcgcaacca ttaaaagggc gtacctctgt 100980
ctacaataag cctttatttt taaatgtttg aagaaatcgt gaagacgact gttgtcaata 101040
caaatatgat aagaacagta ctacatcttt gctccgcaat aatagtacag cttcaagtaa 101100
tattcacagt aaaatggtat gtctggtact aagactttca tgactgttcg acgtttatac 101160
tttaagtata aagagtagtg atccgatgtc tggagattat tctacatcca attgactcta 101220
agcacagcct tcttggcttg ctagtacatt gaaagtgata tactcaactg gacgagactc 101280
gaaaggaaat atgattgacc ataagaccgc tttgtttcga catcgtctta gtacagtact 101340
cataattatc atcattcttt tagtgcctat tacaatgttg gcaaaagaat aaatctccat 101400
cacacttctt gaaaatgtac ttggtcgttt gattgttgag aaagtttaat gatgagtatg 101460
ttatttaagg cactggtgta ctgatagagt tggactaaat gttaattacg agtatataac 101520
tcttcaataa ttcgctctat acgcaaattc ctattatctg tgaaatgttt aacgcctatg 101580
gtaactctgt aaaatattta tctacgttat accttagaat atcttaacgg actatcgcaa 101640
tatatctact tgtactgatt aatgggaaag taggtgcgat aatcgaaggt atggtaaacg 101700
ccggtaagta attctaggca acaaggaatg ttattttttt aattattttt taaggcattg 101760
tacgtctaaa tcatcaataa aatttgttga aatcaccttg tttgattttg taaaaatttg 101820
tcttaaaact atcaccgtta attaaagatt actacactat aattccagaa tttacattct 101880
taagctattt aaactaatct gtttccctag gcttctataa aatcgcgtca gtgattatcc 101940
cccttggaga cggatgtttt tcgcaaataa caattaacaa atttctatgt cacttctgct 102000
gtcagcaatt ttgtttttac tatacttgtt atgatgtaga ttcgtcgcgt tattgcgttg 102060
tcgaacttca taaaaagtgt ctttttacca tgcagatcaa gattgtgaaa gtatagacaa 102120
gcagcaaata cgaaaatcat atttttgatc acatggccac agacctctag taggaagaac 102180
gtttactgag gttcgtgtcg gtagtaccaa acattcatgt aactctgaca atgcgaattg 102240
acctgctttg agctcttcta tatactaact agcattctgg cgaaacaaag ctgtggtagt 102300
attgtgtcat gagtactaat agtagtaaaa aaatcaggga taatgtttcg acggttcact 102360
tatttagagg tagtgtgaga tacttttacg tgaactagca aaataacatc tcttttaaat 102420
tatttgtctt acaattactt ccgtgatgac atgattatct caacccgata tacaattgat 102480
gttctcatat tgaaaaatta ttaagccaga tatgtattaa agcatagtac atacatcaca 102540
agttccggat atcgttaaga ctatttataa ataattccat tgtggaatct tataatataa 102600
cctgatagcg ttatgttggt gaagatggca aattacgctc tcaccggcgc tattagcttc 102660
cataccagtt ggcaacattc attaagatcc gttattcctt aggaaaaaaa tatttataag 102720
aaatcctgta acatgtgcat ttaatagttc taattaacaa cattactcga gcaaactaaa 102780
acttttaaac acagaatttt agcagaggct aataatatga tatgatatga aattagggtc 102840
tatatagtta taatttgata aattaaatta gattaggagt ttggaagata atttagcaca 102900
gttagttata gacgaaggat ttgccttcaa aaagcggtta ttgttatttg tcttaagttt 102960
cagcgaaaac aggagtcgtt aaaacaaaaa taatatgtcc aatattacat ctaagcaagg 103020
caatttcgca acaggttaac ctattttttg tagaaaaatt agaggtccag ttcaaacact 103080
ttcatttgtg cagctcgttt atgcatatgg tgtgtaaact ggtgcgtcgg tgtatggaga 103140
ccttccttct tgcgtatgat tgcatggact gcgatcacgt tttgtaagtt cattgagact 103200
gttacgctta attgctcgga attcgagaaa ataaacgact attcgtaata acgctttgat 103260
cgaactcgat cataacagag cacacatgat aatcttcact tttttagtcc ctattacaaa 103320
gcagcggagt gaatatatgt ctatcagtca ctatgaattt gcatatgatc gttttactgt 103380
agaattaatt taataaatag aatgtataag aaggatctac tgtacttata caaccaggct 103440
acatattaac tacaagacta tatcctatta ttgacttagt gtatacataa tatggtttca 103500
tacatgtagt gttcaagggc tatagcaaat ctgatgataa atgattaggg taacacctta 103560
gaattatata ctagcctatc ggaacacaag cacttttgcc gtataatccg agtgtcgcca 103620
cgataatgga aggtatggtc gatcgttgtt gctattagta ggcgataacc tatccttttt 103680
tcataaattt tctttagaac attgtttaca aaatatatca ggattaattg atgtaatgag 103740
ctcgcttgat tttgaatact agtgttttta attcgactcg gattaataca ctatactaaa 103800
ttttaaagcc agatatatca atattaaact acttaattta acctaatcgt caaacgatct 103860
attaaaccgt gtctatcagt atctgcttcc tgaatgatac tttatcgcca aaatcaatag 103920
ttagaaccta aagtcgcttt cgtccttagc tacatcgatt tctttataca ggtagtaacg 103980
taaattcatt ccgtaaaacg gtttttcact tggttataaa acatttcttt gatctccagg 104040
agaaatatga gatactaaac acgtcgagaa tttacgtttg ctgctcattt gtccacgcac 104100
ccacatacct ctggaaggaa aaatacatac taacctacct gatgctagtg taaaataccc 104160
aagagacgct gacagtgcga tttaacgagc ctttaactgt tacattagct gataaacatt 104220
attgcgtgac tagcttgacc tcgtattgcc cagtgtgtag tattagaagt gataaaatca 104280
ggcttaataa gtcgtggcgt catttacata ttgttagccg gtgacaggta aatgtatagt 104340
agcataacgt aatcttaatt aaattattta tcttacacat tcttcctaga tgacatgaat 104400
atactggtac gatgtataat tgaacttttg atataggata agaactggaa cacatatata 104460
ttatacttat gcttgtacat cctaagtttt caatatcgtt tagggtacaa tttacaaatc 104520
cctttccgga atcataatat aagatcggat aaccttgtgt tcgtggaaag ggtacatttg 104580
ggtcacagta gtggtattac ttatgaaact agctagcaat aacgaaaatc atgtactact 104640
gagcaggaaa attgtattta aaagatgact tataagtaat gttttacatg gtcctaattg 104700
attacattac tcgggggaac taaaacccat gaccactaaa ataaagctga gtctaaatgt 104760
gtgatttgat ttaaaatttc gatctatata tttataattt cgagagataa attggatttg 104820
ctatttgtta gtcgatttgg cacagaatga ctcagacgaa gaacttacta tgaaatggcg 104880
gtttcagttg tcaatgatgg atttcagcga aactaggaaa cgatgtggct taagaaatac 104940
ctctctcatt gcatttagat aaaacatctt gctaaaaaaa gaaccagtac tttgtaaagt 105000
aactagagat tcttttaata ctctgtgatt tgtccagttc ttaaaagcaa acgaggagta 105060
atcaggtgcg tgggtaaaag caaagctaca tttttaagta taatcagata gactacgatt 105120
acattatatg ggatctgtgc gactgtcacg gtaatacact cggaaaatga caatccaatc 105180
cacaactagt tataacccac tgatcgtaat ggagcataac gggtctcaca tcataaattt 105240
tactaattta atccgaattt ttcaacattg cggtagacgt gtaacaaccg accactggcc 105300
atctacatat tattatattc cataagtttt aacttaatat atagaaaacg cgagtaggat 105360
ctactgtact tatatcacct tgctacatat taagatgtaa gctaagtcca atacttgtcc 105420
ttgagcataa atttcaaaaa taggaagttt ttggattcag aagttatagc aaaacccacc 105480
ctaaacgttt ggggaatggt tttagcatta tatcctaacc tattagaaca gaagcaccat 105540
tcccatgtta accctgcgac ttcatcacat tgaatacttt tttcgattaa tattgttttt 105600
aatttatgat cactccacct tctaacataa attttctact gattatttat aacaatatgt 105660
acgaggatta gccaaggtgc cgagcgcccg tggttttggg tactggagat tttatttcga 105720
ctcaaatctg cgcactaaag taaattttaa agttagacat acagataata taggtctcta 105780
tatgacgtaa aggataatca aatagctaaa gcgtatgtta ctgagtctgt ttcttgagtg 105840
ataccttagg ctcttagtcc acggttacta gcaagactag ttttgtactt tcgatacacc 105900
gaactgctta tgaagagagt aacataaatc tattttctag aacgacttta tcctaggtca 105960
tgaaacattt cgttcaactc ttagaatatt acaaaacatc aagtagccca agatttttgg 106020
tttgcacctg attaatccac gcacccattt ttagatcgat gtaaagattc attaaagtct 106080
atttgatact attcaaatat accctacgca tgcggtcaga cgtattatga gactctctta 106140
ctgttaggtt aggtcttgtt cgatactcaa tgtctgccaa tacttcattt tgcccacaat 106200
gtcgaattta aatcggtcat attaggtcct caaagttgta acggcatctc cacattgttg 106260
agtggtcacc ggtaggtgta taataatata aggtattgaa aattgattaa aataaacatt 106320
gcgcccgttt tatataaaac aaattcagtc gaacgatgca agaatctgta ttcgaaccaa 106380
gttatgagcg cgaatttctt tttaaagttt ttgtcgttca aaaacctgag agtttaacaa 106440
tgttttacgt gggacatgca atccccttac caatgatgaa atataggtaa gaacaaatct 106500
gtcttcgtgc taagggtaca attaggaggc tgaagtaatg taacttatat gcaagggaaa 106560
ttataagata aattaaattc cagtaaggta gtagattgtg atttaaagat gactaataaa 106620
tattgttata catcctccta atcggttcta cggtttacga ccatcaaaat ccaagacctc 106680
taaaatagag ctaaatttag acgcgtgatt atacttaaga tatcaaactg ttcgtctatt 106740
gtatccagag atattctgta tcccttatta atttatggat ctcgtattca atgactcatt 106800
tatagaactg agtatagaat ctaaggatcg ggggccaatg atccttccga tcagaacatc 106860
aaagctatct ggtctgacga tttcttctct caatgacttt agaaaaaaaa tcccgctgca 106920
ttaggatcta gtactaagta taccaggttg tgaatcttat aatgtttaga agatcaatgg 106980
attttaaaaa ctaaacgtgg accctttagt aacgtaagct aaaatctagc cacatttcta 107040
actagtttga ggtaaattat aataggttta tatggtatac gtaccctatt gtgcataata 107100
ctttaagtga aaagcaatcc aatgttgatc aagctttgaa taacaaacga ttatgatgta 107160
ataggagtgt aatcgcttat attaaccgag agatttttag gagtatcaac attacccttc 107220
ggctctaata actcactagt ggtcatcgac atgataaaat attcgataat ttttaactaa 107280
ttttatttgt atggcgggca taatatattt agtatgagtc tgcttgtaac gatgttagac 107340
ataagcatgg ttcaatactc gcgcataaag aataatttca aaaacagcga gtgtttcgtg 107400
tcccaaatag ttagtaagtg taccctgtac gctagcatga cggttactac tatataacca 107460
ttcttcaata gacagaaaga agattctctc gttaattttc caacttcttt acgttatata 107520
tacgttccct ttaattacct attagaatta aggacattcc atcgtgtaac actgaatttc 107580
tactgattta ttataacaac atgtagatgg attaggcaag acccgaaatg ctggttgtca 107640
ttgcttctgg ataatttttc tcgaactata cctgcgcgtt gatatcaatt caatggatct 107700
acaagcagaa aagataagtc ggtttaagac aatgggaaaa gttagatacc tagagtatta 107760
attatcgagc aaatatcttc tcatatatga tagattccta cctcccggtt gctaggaagg 107820
ttagtcttgt agtttctata gacctgactg caaaagagga gagttcctga tatctttttt 107880
ttagggtaac gtaatcctag atggtgtttc taatggacca acatttagaa cgttacaatt 107940
cttctagtta cctagtattt ttattttgca cgtgggaaat cattgcttta gattctagat 108000
ctgtataaag attgatcaga cttgaatcta atttgtccaa attatccatg tgcttgagac 108060
agcatatatt atgaaattca ctttacaaaa ggtcacaact agttagagac ttattgtttg 108120
ctaatattac tttaatctca catttgcaat tgttgctggc tctctaaaaa tcgtcgtagt 108180
atcaatggag agccgagatt atagagtgtt taccagtagc taaactattt aacaagctat 108240
taaagataga tcaaagtaaa cataccgcct gaaatattta aatcatagtc agaccaaatt 108300
tgctacaact cgtattcaca ccaacttttg acggcgtatt tcccatttaa gcttttgttg 108360
ctcacaaaac acttggtata cgtattaatc tcatgggaca tgcgatcgta ctgtgtacgg 108420
aggtgtttcg gtaagaagtt atgtcatttt tatctaagta agcagataaa aagataaaaa 108480
tatgcaatat aaatgcaaga gaaattaatg gacgatctta attcctgtaa ggtaacacat 108540
cctgactcaa aagtcattaa ataatataat tgaacttctg gttaatccgt tctgggctgt 108600
tcaaccaaca gttacggagg cttattaaga agattttgat acggacccgc aactatcgtt 108660
aggtaacttt gaagtccgtc ttttcgaatc agccaaattc acttaccttt ttgaatcttc 108720
gcaagtcata actaatagct cctttataaa agagtaaaca ctgtctaaag gtggagggcc 108780
aagaatcctt ccaatttcca cattaatgat aactgcactg acgttttctc ttctctagga 108840
caaaagtaaa aaattgccat tgcactagga cttaccgcaa atattacctc gttatatata 108900
ttgcagcctt aagaacatca atagatcata aaaataaaac atgtatcctc tattattaaa 108960
atgtaagttc taaacaaagt acgaattagt ctgaacttac attaaagaga tttagtaggt 109020
acacggtctc tgtcgtataa attactttat ttgaaatgtt ttccagtatt aatcaatccc 109080
tgaatagcat acaattataa tgagactaga ctataaacgt tagcgacgac agagagatta 109140
taagcagcat catagttatc tctccgctct agtatcacac aaatggtcgc cgttcagata 109200
gattggtcaa taatctccat gaactatcgt ctgtatggcg gactttataa atctagaatc 109260
agtctaattt aaatgatgtt gagcatttgt gtgctaaaaa accgtcacat aaagcgtata 109320
ttcgaaaaca acgaatgtcc tgtgaaccat atgcattatt agagtactct gtagacaagt 109380
atgacacatg gctccacaag gctatttatc gatacaatat aaatagatat attcggctat 109440
ttttctgttt atatccgtaa tttttacgtt gtttttaatt acttgccaga gttaatgact 109500
ttccatagcg aggaaccggg tattgagttt ttcactatat aagcttgatg actactttgg 109560
gtagtcccga caagttagat ctgaatgccc tcgaataata ctccaaaaac aatgcctggc 109620
tgttggcagc actgcattga aacttcaggc agaaaggcct agctggctta accaagtgga 109680
aaaacttaga agcgtcctat tatgattatc aacgaaaaac attttcattt gtgagagata 109740
tccaccaccg gatactcaaa aaggttatag gaataataac tattaagatg agtacagtgg 109800
agatgatatc atgtttagat aatatgacgg taacgtgatc tagaatgccg cttatgagag 109860
agtaatgtat ttaacgtcgg agtccctgta gttatctact atttatattt caaatacagg 109920
agttaacatt ttaacattca agaattgttt catgcataat cagtcttgaa tgtaattact 109980
gtaattcata aatgtgtcaa agacactata tctaatcaag taaagtttag aaaaaggcat 110040
aatcagttac ggagttatct tatcttaata ttattctgat ataatatttg caatcgctgc 110100
tgtctctcca actttcgccg taatatcaat agacaggcaa gctcttgcta tatttttcaa 110160
gggcatgtct aactatccaa tcataagagg gactcgacag cagaggtact gcctgaaata 110220
tcatcatgtt agtgaaatta aattaagtac cagtcgtaaa gacacggttt tttagcagtt 110280
tatttcgcat ataagcttat gttacttaca cgatacctgg tattcgtaat gatcttatga 110340
ggcgtctgtt gatacagtat tccgaggcgc tgcgttaaat tgctatgata tagttatttt 110400
tattagtcga taaaaagaca aatatagcga ttaagaatgc aacaaattat aacgaacggc 110460
ctcaaatagt agaaaatatc cctcctccgg ccatctccta aaatgccata tattcggatt 110520
attgatgatg gtcaccaggg cagttttatc tagtctcata ggtgtttatt ttgaggttat 110580
tcttaccgac tgtgaaccgt cgtgtcgtag ctttgaaccc ggtgtttccg gattgtctga 110640
cttggttcac ctttttgatt cttcataggg ttatactaat tgacacttat tctaaaagta 110700
aacactcctt ataggtagtg gtgaatgagt tttagcatta tccttattat tgataatttt 110760
actcttgtca catgtattac agtacgaact tattatacca ccataccact agatcttatg 110820
gagaatactc tctcaatact tgaattggac ccacagagac aagtatagaa gataaacgta 110880
gagattatgt cctcagttgt ataattgtga gttctcaaca aagaaggtat acgtcaatac 110940
attcagtaac gacataaggt atttggacag tttcagtgat atagaccaat acatttcaga 111000
tctctttacg tatcagtaaa tgcctctata gagttgattc atattaacac tattttacaa 111060
acgtcaccga cgacagagag gttgaaagcg gcactctact aatttgttca tgtgagaaca 111120
atatataata ttcgagtaca cattgatggg atagtgttct cgctaggctg tccactccgt 111180
aattgtcctt aaagtagtac agtcgcatta atttaatacg tggtcagcat tttagcgtga 111240
aataatcgtc aaattgtacg catatcagat tgggatgtat gtgctatgga cttttagcat 111300
tacttgaatc attccctatc aattttgcca taaggcttcg ccacgtaatt aagcgattcc 111360
ataccaataa gaataatgtg ccgaatcttt gttaatatca ccgattctta cgttgatcaa 111420
taatgcttgc cggtgcttat catcatttaa aggaaggacg cccgaggagg actttacggt 111480
aaatatgccc aataacttcg gctaatgatg ttatctaaat aagttggagt ttccagatat 111540
aagggccgaa taagaatcga ctatacagcg cagcacaggg tcgaaactca cgcaattgtg 111600
gcctaacaga ctgaatcaag tcgaaaacct atggagtagc ccaatatgat tgactgtgaa 111660
taagaaattt attccaaggg aataaccctg atcattgact ctaaactcta ataggaataa 111720
agattactag aatggagaaa gcgtacttat tgtcatgctc gaatgaaatg ctccaatagt 111780
gaataagttc acctcctatg agaaggttaa gaacttttcc tgcatctctc aacttacata 111840
atctacccgc atgcgtaata cacgagtcaa catattaaca cacaaaagtt ccttccttca 111900
tacgcagtta agcaagtcat agctgtattc cataaacctt tcaaaatcac tgtatctggt 111960
tatctaaaaa ctagagaaat ggctagtcat ttatggtaat atctcagtta agtttaaatg 112020
cgataaattg tgtgttgcgg ctcctatttt cccgacttta actgtcagat gataaaacaa 112080
gtacacactt gttaattgtt atttgcttat gtgcaactac gctatcacga gaccgatccg 112140
acaggtgaag catataaaag aaactcatca catctgcata attatattgt acatcggtct 112200
tagaatcgta ctttgctact aattttacat gcgtatggtg caactctaca tacacgatat 112260
ctgaaaatca caatggactt tgtatcaggt agctaaaacg gtattctgaa gccgtgcttt 112320
aattcactaa agtgtggatg ttctctttac acggcttaga tactattata gtggcaagca 112380
acataattag ttattaccat cgccgacgta taatagttta cttcctcggt gtgggcccct 112440
cctcaaatgc cacctatagg gcatgttgaa gccgattagt acaatagatt tattcaaccc 112500
caaacgtcaa cagtcccgct ttagtctaag ctgatatgtc gggtcaagtc tcgggattga 112560
gtgcattagc actggaatgt ctcgctcagt tcaattattg gatagctcat cgagttatac 112620
tctctcacac ttattcttta aataacgttc cgttattagg attaataact gtcgtttgaa 112680
actattctta tttcttatcg tgttaagtct ttcgcatgaa tgacagtatg agcttacttt 112740
acgaaataat ttctttttca actgcaggat actcttctaa ttcttgaaga ggacgtagag 112800
tgttggatgt attagaagcc cctacccatt atctatccac ttgtatattt atctcttttc 112860
aaagatggaa gtttgcatca atttgttcag tatcgatata gggtgtttgg aaagtattag 112920
tgacatagcc caatagattc ttcattacca taccgatcag taattaccat taaacagtca 112980
attctgttct acgccattta acacataacg cccaggataa cagagctgaa tttgacagac 113040
tacaatattg tttatgtgtc atcaattaac agttaacgaa tacatgacga tgcggaacac 113100
ctctggccag gccgcgcact tcgtatattt actttgagca gtgtaggtgt aataatatag 113160
catgtagcca catccttagc ttgaaccgga gataaaaatc tacgcacgcg acgttcacat 113220
ttatatggtt tagattttta gtgctaccca aaacaaagtc catagatttt tcattaagac 113280
tacggcgcga agttaagtga tttcacacct acaagagaaa tatgcccaaa ctatgaaaat 113340
aacatcgttc gtagaaataa tcaatcgtga taggggttgc atattgtcaa atgaaagagc 113400
cacactcggg gagcagttca cggacgtcat ctcgtgcaac ttcggctaat catataatct 113460
aaaaaagttg aggtttgcag ttgtcagggc gaaatcaaat tcaagtatat agtcctgttc 113520
agagccttaa ttcacgtatt cgcgaccctt gaaagcgcgt caagcttatc actcattgac 113580
tagctcaatg tgtggcaatc taaataagaa gtctattgca aggcaaaaat gctaattatt 113640
gatagcaaac ttagataagg tagaagaatt gcacaattca gaaggcgttt tttctgctat 113700
actcgaatgg aatgctttat taaagaaaag cttgatgtcc cacgagatga acgagaactt 113760
ctatagcatc tcacaaccta cttaattttg ggggatgggt aaaagttagc tgaacataca 113820
aataggaata agattgtacc ttcaaacgaa actaaacaaa tcatagttaa tccgcacaaa 113880
gtttacatat taattcttac ggcatatcaa agaggtaatg gcttgacttg tgatgaatca 113940
tagtttgtga gtaacgacaa gatgcggtaa atactgtaat gcgagtttta ttgactcgac 114000
ttaaagtttc tgatattata ataaatacac agtggttaat tgtcaattgc ttatgcactg 114060
ctacaccttg tggtcctcgg tccagcctgc gtaggatata aatgaagcac gtctcatcca 114120
gattgttcta tcgtacttcc aaatacgaat tcaacttggc gtctatttcc agatatgagc 114180
cctagaagtg atagacttcc aaatctaaaa attaccatgg gatatgtttc acgtatccaa 114240
aaagtaatta taatactgcg tttccattca cttaagtgag gatgttgtct ttatactggt 114300
ttcatagttt tgttgtacca agcatctttt ttagttagca ctatttccaa cctaaaactg 114360
ttttgtttct cgatgtgaga cccttgtcag ctgcctgcgg tggtgcacgt aaaagccgat 114420
tagaatatta aatatttaca actccaaatc ttaagagccc tgctctagtt taaattcata 114480
tatcagcata ggcttcgcaa tttagtgaat aagcggtacg aactttcgcg gagtacgaaa 114540
agtgactaag taatcgagat acataccgtt agattcatgc ttcagacagc attctgaatt 114600
tttgatttat aaccatcgaa ggaatcaatt tcatgttcct aacgtgttaa gtcatccgca 114660
aaaaagacga taagagctac cagtgcattt taatttgctg ttatattcgt tatagttatg 114720
atatcatttt ctatagcctc taccacttaa tcctatgaaa cttgcgtttt aagtattttc 114780
actatgtggc ggtcttttag gtcagttact atgcgaaacc atactatgtt cattgggact 114840
acaacgacag aacgcatcta taaccttacc agctacctaa cttcgttgtg gtttactaca 114900
actttttaat ccaatctatt gttctctctt ccgcgataag tcacttaatt tgttattaaa 114960
ctaattaaat agatatgttg ttcgattcct aagtacatac atcacaagtt cccgatatcg 115020
ttaagactac tttttaataa ttccattgtg gaatcttatt atatgaccgg atagcgttat 115080
gttggtgaag atggcatatt aggctctcac cggtgctatt agcttccata ccagttggca 115140
acattcatta acatccgcta ttccttagga aaaaaatatt taaaagaaat cctgtaacaa 115200
gtgcatttaa tagttctaat taacaacatt actcgagcaa actaaaactt ttaaacacag 115260
aaattaagca gaggctaatt atgtgatatg atatgaaatt agggtctata tagttataat 115320
ttgataaatt aaattagatt aggagtttgc aagataattt agcacagtta gttatagacg 115380
aaggatttac tttcaaaaag cggtttttgt tatttgtctt agatttcagc gaaaacagga 115440
gtcgttaaaa caaaaaaaat atgtccatca ttgcatctaa gtaaggcatt ttcgcaacag 115500
gttaacctat tttttgtaga aaaactagag gtccacttca aactctttga tttgtgcagc 115560
tcgtttatgc atatggcgtg taaactggtg cgtcggtgta tggagacctt cctttttgtg 115620
tatgattgga tggactgcga tcacgttttg taagttcttt gggactgtta cgcttaattg 115680
ctcggaattt gagaaaataa acgactattc gtaataacgc tttgatcgaa ctcgaacata 115740
acagatcaca catcataatc ttcacttttt tagtcccaat tattgagcag cggagtaaat 115800
atatgtctat cggtcactat ggatttgcat atgatcgtat tactgtagaa ttaatttaat 115860
aaatagaatg tataagaagg atctactgta cttatacaac cacgctacat attaacttca 115920
agactatatc ctattattga ccttgtgtat acataatatg gtttcataca tgtagtgttc 115980
aagagttata gcaaatctca tgttaaatga ttagggtaac gccttagaat tatattctag 116040
cctatcggaa cacaagcact tttcccgtgt aatccgagtg tcaccacgat aatggatggt 116100
atggtcgatc gttgttgcta ttagtacgcg ataacttatc cttttatcat aaattttctt 116160
ttgaacattg tttacaaaat gtatcaggat taattgatgt aatgagctcg cttgattttg 116220
gatactagtg tttttatttc gactcggatt aatacactat actaaatttt aaagccagat 116280
atatcaatat taaagtactc tatttaacct aatcgttaaa cgatctacta aaccgtgtct 116340
atctgtatct gcttcctgaa tgatacttta tcgccaaaat caacagttac tacctaaagt 116400
cgctttcgtc cttagctaca tcgaattctt tatacaggta gtaacgtaaa tctattccgt 116460
agaacgattt ttctcttggt tataaaacat ttctttgatc tccaagagaa atatgagata 116520
ctaaacacgt cgagaattta cgtttgctgc tcatttgtcc acgcacccat attcctctgg 116580
aagtaaaaat acatactaat ctacctgatg ctaatgtaaa atacccaaga gacgctgaca 116640
gtgcgattta atgagccttt aactgttaca ttagctgatg aacattattg ggtgactagc 116700
ttgacctcgt attgcccagt gtgtagtatt aaaagtgata aaatcaggct taataagtcg 116760
tagcgtcatt tacatattgt tggccggtga caggtaaatg tatagtagta taaggtattc 116820
ttaattgaat tatatatctt atacattcat cctagatgac atgaatatac tggtacgatg 116880
tataattgta ctttcgattt aggttaagaa ctggaacacg tatatataat acttatgctt 116940
gtataaccta agttttcaat atcgtttagg gtaggattta caaatccctt tccgaaatca 117000
taatataaga tcggataacc ttgtgttcgt ggaaagggta catttgggtc acagaagtgg 117060
tattacttat gaaagtagct agctataacg aaaatcatgt actactgagc aggaaaattg 117120
tatttaaaag atgacttata agtaatgttt tacatggtcc taattggtta cattactcgg 117180
gggaactaaa acccatgacc actaaaataa agctgagttt aaatgtgtga tttcatttaa 117240
aatttcgatc tgtatgtcta taatttcgag agatatattg gatttgctat ttgttagtcg 117300
atttggcaca caatgactca gacgaagaac ttactatgaa atggcggtat cagttgtcaa 117360
tgatggattt cagcgaaaca agaaaaccat gtggcttaag aaatacttct ctcattgtat 117420
ttagataaaa catcttgcta aaaaaagatc cagtactttg taaagcaagt agagattctt 117480
ttaatactct gtagtttgtc cagttcttaa aagcaaacga ggagtaatca ggtgcgtggg 117540
taaaagcgaa gctacatttt taagtataat cagataaact atgattagtt tatatgggat 117600
ccgtgcgact gtctccgtaa tacactcaga aaatgacaat ccaatccaca acaagctatg 117660
acccactgat ggtaatggag cataacgggt ctcacagcat aaattttacc agtttaatcc 117720
gagattttca acattgcggt agacgtgtaa caaccgacca ctggccatct acatattatt 117780
atattccata acttttaact taatttatac gaaacgcggg taggatgtac tctatttaaa 117840
tcaccttgct acgtatttag atgtaagctt agttcaatac ttgtccttga gcataaattt 117900
caaaaatagc aagtttttgg attcagaagt tattgcaaaa cccaccctat acgtttgggg 117960
aatggtttta gcattatatc ctaacctgtt tgaacagaag caccattccc atgttaaccc 118020
tgcgacttca tcacattgaa tactctttcc gattaatatt gtttttaatt taagatcact 118080
ccaccttcta acacaaaatt tctactgatt atttataaca atatgtacga ggattagcca 118140
agatgccgag cgcccgtggt tttgggtact ggagatttta tttcgactca aatctgcgca 118200
ctaatgtgaa ttttatagtt tgacaagcag ataatatagg tctctataag acatagagga 118260
taattaaata gctaaagcgt atgttactga gtctgtatct tgagtgatac cttaggctct 118320
tagtccacgg ttactagcaa ggctagtttt gtactttcga tacaccggac tgcttatgaa 118380
gagagtaaca aaaatctatt ttctagagcg actttatcct aggtcatgaa acatttcgtt 118440
caactcttag aatattacaa aacttctagt aacctaaaat ttttggtttg cacctgatta 118500
atctacgcac tcgtttttag atcgatgtaa agattgatca aagtctattt aatactattc 118560
aaatataccc tacgcatgcg gttagacgta ttatgaaact ctcttactgt taggttagat 118620
ctagttcgat acttaatgtt tgccaatact tcattttgcc cacaatgccg aatataaatc 118680
ggtcttaata aatcctcata gttgtaacgg gaactccaca ttattgagtg gtcaccggta 118740
ggtgtataat tatataaggt attgaaaatt gattaaaata aacattgcgc ccgttttata 118800
taaaacaaac tcagacgaac gatgctagaa tctgtattcg aaccaagtta tgagcgcgaa 118860
tttcttttta aagtttttgt cgctcaaaaa cctgagggtt taacaatgtt ttacgtggga 118920
catgcgatcc cgttgccaat gatgaaatat aggtaagaac atatctgtct tcgtcctaag 118980
ggtgcaatta gaaggttgaa gaaatgtaac atatatgcaa gggaaattaa aagataatct 119040
aaattcctgt aaggtagtag attgtgattt aaagatgact aaaaaatatt gttgtacatc 119100
ctcctaatcc gttctacgct ttacgaccaa caaaaaccaa gacctgtaaa aaagagctta 119160
atttagacgc gtaattatac ttaagatatc taactgttcg tcttttgtat ccagacaaat 119220
tctgttaccc tttttaatct atggatctca tatttaataa ctcatttata gaactgagta 119280
tactatctaa ggatcggggg ccaacgatcc ttccaatcag aacatcaaag gtatctggtc 119340
tgacgatttc ttctctcaat gactatagaa aaaaaatccc gctgcattag gatctactac 119400
taagtttacc tggttgtaaa tcttgtaatg tttagaagat caatggatta taaaaactaa 119460
acgtggaccc tttagtaacg aaagctaaaa tctagccaca tttctaacta gtttgaggta 119520
aattaaaata ggtttaattg gtatacgtac cctattgtgc ataatacttt aagtgaaaag 119580
ctatccaatg ttgatcaacc tctgaataac aaacgattat gatgtaatag gagtgtaatc 119640
gcttacatca accgagagat ttttaggagt atcatcatta cccttcggct ctaataactc 119700
actagtggtc atcgacatga taaaatattc gataattttt aactaatttt atttgtatgg 119760
cggacattat atatttagta tcagtctggt tgtaacgatg ttagacataa gcgtggttca 119820
atactggcgc ataaaggata aattcaaaaa cagcgagtgt tttgtgaccc aaatggatag 119880
taagagtacc ctgtacgcta gcatgacgca tacttctata tagccattct tcaatagaca 119940
gaaagaagat tctctcgtta attttccaat ttttttacgt tatatatacg ttccctttaa 120000
ttacctacta gaattaagga cattccattg tgtaacactg aatttttagt gatttattat 120060
atcaacatgt agaccgatta ggcaagaccc gaaatgttgg ttgtcattgc ttctggataa 120120
tttttctgga actatacctg cgcgttgata tcaattcaat gaatcttcag gcagaaaagt 120180
taagtcggtt taagtgaatg gaaaaagtta gaaacctaga gtattaatta tcgagcaaat 120240
atcttctcat atatgataga ttcccacctc ccggttctta ggaaggttaa tgatgtagtt 120300
tctatagacc tgactgcaaa agagaagagt tcctgatatc ttttttttag ggtaacgtaa 120360
tcctaaatgg tgtttctaat ggaccaacat ttaaaacgtc acaattcttg tagttaccta 120420
gtatttttat tttgcacgta ggaaatcatt gttttagatt ctagatctgt ttaaaggttg 120480
atcagacttg aatctaattt ctccaaatta tccatgtgct agagacagca tatataatga 120540
aattcacttt acaaaaggtc acaactagtt agggacttat tgtttgctaa tattacttta 120600
atctgacatt tgcaattgtt gctggctctc taataatcgt cgtagtatca atggagagcc 120660
gagatcatag agtgtttacc agcagctaaa ctatctaacg agctattaaa gatacatgaa 120720
agtaaacata ccgcctgaaa tatttaaatc atagtcagac caaatttgct acaactcgta 120780
ttcacacgaa cttttgacgg tgtatttccc atttaagctt ttgttgctca caaaacactt 120840
ggtatacgta ttaatctcat gagacatgcg atcgtactgt gtacggaggt gtttcgataa 120900
aaagttatgt catatttatc taagtaagcg gataaaaaga taaatatacg caatataaat 120960
gcaacagaaa ttaatggacg gtcttaattt ctgtaaggta acacatcctg acccaaaagt 121020
cataaagtaa tatatttgaa cttctggtca aaccgatcag ggctgttcaa ccaacactta 121080
cgggggctta ttaagaagat tttgttacgg acccacaact gtcgttaggt aactttgaag 121140
tccgtctttt cggatcggcc aaattgactc acctttttga atcttcgcaa gacataacta 121200
atagctcctt tataaaagag taaacactgt ctaaaggtgg aggcccaaga atctttccaa 121260
tttccacatt aatgataact gcactcacgt cacctcttct ttagaacaaa agtaaaaaac 121320
tgccattgca ctaggactta ccgcaaatat tacctcatta tataaattgc agccttaaga 121380
acatcaatag atcataaaaa taaaacatat atcctctatt attaaaatgt aagttcttaa 121440
caaagtacga attagtcaga acttacatta aagagattta gtaggtacac ggtttctgtc 121500
gtataaatta gtttatttca aatgttttcc agtattaatc aatgcctcaa tagcatacaa 121560
ttataatgag actagactat aaacgttagc gacgacagag aggttgtaag cggcattata 121620
gttatctctc cgctctagta tgatacaaaa ggttgccgtt cagatagatt ggtcaataat 121680
ctccctgaac tatcgtctgt atggcggact ttataaatgt agaatcactc taatttaaat 121740
gatggtcagc atttgtgtgc taaaaaaccg tcaaataaag cgtatattcg aaaacaacga 121800
atgtcctgtg aaccatatgc attactagag tactccgcag acaagtatga cataaggctc 121860
cgcaaggcta tttatcgata ctatataaat agatataatc agctattttt ctgtttatat 121920
ccgtaatttt tacgttgttt ataattactt gccagagttt atcactttcc atagcgagga 121980
agccggtata gagtttttcg gtatataagc ttaatgacta cttcgggtag tcccgacaag 122040
atagatctga ataccctcga ataaaactcc aaaaacaatg gctggctgtt ggcagcactg 122100
cattgaaact tcaggcacaa aggcctagct gacttaacca agtggaaaaa cttagaagca 122160
tcctaatatg attatcaacg aaaaacattt tcatttgtga gggatatcca ccaccagata 122220
ctcaaaaacg taataggaat aataactatt aagatgagta cagtggagat gatatcatgt 122280
ttaaataata tggtggtaac gtgatctaga atgcccctta tgagagagta atgtatttaa 122340
cctcggagtc cctgtactta tctactattt atatttcaaa tacaggagtt aacattttaa 122400
cattcaagaa ttgtttcatg cataatcagt cttgaatgta attactgtaa tccataaatg 122460
tgtcaaagac actatatcta atcaagtaaa gtttagaaaa acgcataatc aattacggag 122520
ttatctcatc ttaatattat tgtgatataa tatttgcaat cgctgctgtc tctccaactt 122580
tcgccgtaag atcattagac aggcaagctc ttgttatatt ttacaagggc atgtctaact 122640
atccaatcat aagagggatt cgacagcaga ggtactgcct gaaatatcat catgttagcg 122700
aaattaaatt atgtaccagt cgtaaaaaca cggtttttta gcagtttatt ttgcgtatag 122760
gcttacgtta cttacacgat acctggtatt cgtaatgatc ttatcaagcg tctgttgaaa 122820
cagtattccg aggcgctgcg ttaaattgct atgatatagt tatttttatt agtcgataaa 122880
aagacaatta tagcgattaa gaatgcaact aattataacg aacggcctca aatagtagaa 122940
aatatccctc ctccgggcat ctcctaaaat gccatatatt cggattattg aagatggtta 123000
ccacggcagt tttatctagt ctcataggtc tttatttcga ggttattctt accgactgtg 123060
atgcgtcgtg tcccagcttt gaatgcgata tcaccggatt gtctgacttg gttcaccttt 123120
tagattcctc attgggttat actaactgac acttattctt taagtaagga ctccttattg 123180
gcagtggtga atgagatttg gcattatcct tattattgat aattttactc ctgtcgcatg 123240
aattacagta cgagcttatt ttaccaggat accacttgat cttatggagg atactctttc 123300
aattcttgaa ttggacccac agagatgagt gtactagatg aacgtacaca ttatgtgctc 123360
agttgtataa ttgtgtgttt tcaagaaaga aggtatacgt caatacattc agtatcgaca 123420
taaggtattt ggatagtttc agtgatatag accaatagat ttcagatctc tttacgtatc 123480
agtaaatacc tttatagagt tgattcatat taacactatt ttacatacat caccgacgac 123540
aaaagggttg aaagtggcac tctactaatt tgttcatgtg tgaacaataa ataatattcg 123600
agtacacatt gatgggatag tgttctcgct aggctgtcca cttcgtaatt atcctttgag 123660
tagtgcagac gcattaattt aatatgtggt cagcatttta gcgtgaaatg atggtcaaat 123720
tgtacgcata ccacgttggg atgtatgtgc tatggacttt tagcattacc tgaatcattg 123780
cctatcgatt ttgccataag gcttcgccac gtaattaagt gattccatac ctacaagagt 123840
aatgtgccga atctatgtta atatcaccgt tccttgtgtt aatcaataat ggtagccgct 123900
gcttatcatc aaataaagga aggacacccg aggaggactt tacggtgaat atgccgtata 123960
acttcggcta atcatgttat ctaaataagt tggagtttcc agatataagg gccgaataag 124020
aatcgactat acagcgcagt tcagggccct aactcacgta attgtggcct aacagaccga 124080
atcaagttga aaacctatgg agtagcccaa tatgattgac tgtgaataag aaatttattc 124140
caagggaata accctgatca ttgactctaa actttaatag gaataaagat tagtacaatt 124200
gagaaagcgt acttattgtc atgctcgaat gaaatgctct attagagaat aagttcacgt 124260
cctatgagaa ggttaagaac ttttcctgca tctctcaact tacataatct acccgcatgc 124320
gtaatagacg agtgaacata taaatacaca aaagttcctt ccttcatacg tagttaagca 124380
agtcatagct gtattccata aacctttcaa aatcactgta tcaggttatc taagaactag 124440
agaaatggct agtcatttat ggtaatatct cagttaagtc taaatgcgat aaattgtgta 124500
ttgcggctcc tattttcccg actttaactg tcagatgtta taacaagtac acagtagtta 124560
attgttattt gcttatgtgc aactacgcta tcacgagacc gatccggcag gtgaagcata 124620
taaaagaaac tcatcacatc tacataatta tatcgtacat cggtctaaga atcgtacttt 124680
gcttctaatt ttacatgcgt acggtgcaac tgtatataca cgaaatctaa aaatcacaat 124740
ggactttgta tcaggtatct aaaaggaaat tctgatgccg tgctttaatt cactaaagtg 124800
tggatgttct ctttatacgg ctttgatact attattgtgg caagcaactt aattagttat 124860
taccatcgcc aacgtataat agtttacttc ctcggtgtgg gcccctcctc aaatgccagc 124920
tatagagcat gttgaagccg attagtacaa tagatttttt caaccccaaa cgtcaacagt 124980
cccgctttag tctaagctga tatgtcgggt caagtctcgg gattgagtgc attagcactg 125040
gaatctctcg ctcagttcaa ttaatggata actcatcgag ttatactccg tcacacttat 125100
tctttaaata acgttccgtt attaggatta ataactatcg tttgaaacta ttccaatttc 125160
ttatcgtgtt aagtctttcg caagaaagac agtatgagct tactttacga aataatttct 125220
ttttcaactg caggatactc tactaattct tgaagaagac gtagagtgtt ggatgaatta 125280
gaagccccta cccattttct atcgacttgt atatttatct ctattcaaag atggaagttt 125340
gcatcaattt gttcagtatc gatatagggt gtttcgaaag tattagtgac atagccctat 125400
agattcttca ttaccaaacc gaacactagt tagtattaaa cagtcaattc tgttctacgc 125460
catttaacac ataacgctca agataacaga gctgaatttg agagactaca atattgttta 125520
tgtgtcacca attaacagtt aacgaataca tgacgatgcg gaacacctcg ggccaggccg 125580
cgcacttcct atatttactt tgagcagtgt aggtgtaata atatagcatg tagcctcatg 125640
cttaacttga accggagata aaaatctatg cacgcgacct tcacatttac aaggtttaga 125700
tttttaatgc tacccaaaac aaagtccata ggtttttcat taagactacg gcgcaaagtt 125760
aagtgatttc actcctacaa cagaaatatg cccaaactat gaaaacaaca tggttcgtag 125820
aaataatcaa tcgtgataga ggttgcatat tgtcaaatca aagagccaca ctcggggagc 125880
agttgacgga cgtcatcacg tgcaatttcg gctaatctta taatctataa atgttgaggt 125940
ttgcagttgt cagggcgaga tcaaattcaa gtatatagtc ctgtccagag ccttaattca 126000
catattcgcg acgcttgaaa gcgcgtcatg cttatcactg attcactagc tcaatgtgtg 126060
gcaatctaag taggaagtct gttgcaaggc taaaaaacta aatattgata gctaccttag 126120
ttaaggtaga agaattgcac aattcagtag gcgttttttc tgctatactc gaacggaatg 126180
ctttattaaa gtaaagcttg atgtcccacg agatgaacga gaacttctat aacatctcac 126240
aacctactaa attttggggg atgggtaaaa gttagctgaa catacaaata ggaatttgat 126300
tgtaccctta gacgaaacta aacaaatcat agtaaatccg cacaaagttt acatattaat 126360
tcatacggcg tttcaaagag gcaatggctt gacttgtggt gaattacagt ttgtgagtaa 126420
ccacaagatg cggtaaatac tgtaatccga gtttaattga ctcgacttaa agattctgat 126480
attataatga aaacacaatg gtttattgtc aattacttat gcactgttac atcttgtggt 126540
cctcggtcca gcctgcgtag gatataaatg aagcacgtct catccagatt gatctatcgt 126600
acctccaaat acgaattcaa cttggcgtct atatccagaa atgagcccta gaagtgatag 126660
acttccaaat ctttaaacta ccatgggata tgtttcacgt atccaaaaag taattataat 126720
tctgcgtttc cattcactta agtgaggatg tagcctttat attggtttca tagttttgtt 126780
ataccaagca tgtattttac ctagcactat tttcaaccta aaactgtttt gtttctcgat 126840
gtcaaaccct tgtcagctac ctgcggtggt gcacgaaaaa accgattaga atattaaata 126900
tttacaactc caaattttaa gagccctgct ctagtttaaa ttcatatatc agtataggct 126960
tcgcaattta gtgaataagc ggtatgaatt ttcgcggagt atgaaaagtg actaagtaat 127020
cgagatacat accgttagat agatgcttca gactgcattc tgaatttttg atttataacc 127080
atcgaaggaa tcaatttcat gttcctaacg tgttaagtca tcagtaaaaa agaccataag 127140
ggctcccctt ttgaaataat actgtttcaa actataggct gccctacttg gtgttcaaga 127200
tactatagag tcttcgatga tttaaagccc ccaacccatg ttcaatcaac ttctatgttt 127260
aaccttaaac taacacagga accagctaag atttgtttag catcatttgg gcacgttaca 127320
tatataaaat aaagtatgcc gcagagtttc tcccttaccg aactgtagtc gacctaaagt 127380
ctaatactca ttggtgttgt atcacttttg tgacattagg tatgatttaa ctcttgaaaa 127440
tttttacgac tatgataaaa gattagagct accaaataac tgttaataat catgtcacta 127500
tgtagatcgc caagaatcag ctgggatgaa tgcattattt acatcgtgca aactaggtct 127560
gagtaggtac catcgtagtt tatgcctaag ttgaaccgca aatataggtc ttttgccggg 127620
atctccacta tctgtaaatt gtgaaacctg ttggtaacct atacaaaata catagctata 127680
tcattagtaa taaaacgtaa acgaaagatc attcactcct tcttcggaaa gataaccaaa 127740
gaattaggag aatatggtgc gcacatagaa aggatcggga aataactttg accttcacag 127800
aacaataagt tacaatttgg gaacagtcgg ataacgccac tacgtgctta tttggtttac 127860
cttaaatttt ataattgatg aggattaaaa ttcacgggag aagatctaac ataagtatat 127920
agttatatct gaagcgtttg aacacttact ccctttactt aattaggcct tattgttttc 127980
cctgactcat aagttctatg attggcaatc tatctacaag gagacacgta tcatttaaaa 128040
acaaaaaatt ggtaacttcc ttagttaaag tgctgggaat gctcaaatca gtagtcttct 128100
tctctggaaa tcgcgagggg ggaattttat catgtcgaag tttgttattg gactcattca 128160
accataggct ccatgatatt aaaagagcta gtaaactacg ggggtaggat acaaatttct 128220
tgataataga aatcggaatt cgaatgtgtc cttggtcgac tcagatccaa tccaagtgaa 128280
cccaacgaat gtatatattt tattacatat ggcgtcttaa acagggaatc ccttaacatc 128340
aactggtttt cagataataa gtaaccgcaa catagtgaaa acacagttat cgatactagt 128400
tagagaacct ttaataatgc tacaaccatt ttctaatctt gatgatttgt tgacaattat 128460
tagttcagcg agccatctaa cggttcttag tcaactctac ttatgcaata aatcttgcat 128520
gtttgacgct aactcaacca tggtagcatc aaatacggat acaattaggg gttaatatgc 128580
agaaaatggg cttagggatg atagacactt tacaaattgc acaagcaatc gaaatgtttt 128640
atgtatcgat atagtatgca tttttataga attgccttct agcatgacag aaacaagcct 128700
atctattcgt ttctttatcc tcctatacca cgtgtgtacc tttcccggcc attcattaag 128760
accggaagta tcttgttata caatattaaa cctttaacag cctatcgcgc tgatacacga 128820
attaaccaaa tgaagtttaa aaaattaact actgttattt ttaagtggct tcttcaagat 128880
tgcattcata tatcaataat gacttactaa ggttctaaat gagagaattc aattaatctg 128940
gataaacaaa agggtctgaa gattcataat accaaccatt aaatagacgt tcctctgtgt 129000
atagtaaatc tttatttttt aacctttgaa gaaatcgaca acacgaccct tgcgagtata 129060
gttatgaaaa gaagagatct tcatctttgc ccccttataa tagtacagct tcaaacaata 129120
ttctcagtaa gatggtatgt gtggtactaa gactttcatg actatttgat gtccttattc 129180
tatgtataaa gagtaataat cttaagtctg gagtttactc agcaaccagt tgagtctagg 129240
cacagctttc ttgggttgct tatatattga aaataatgta ctcaacagga tcagtctcat 129300
aaggaattgt gattgaccaa aagtccgcta tgcattgacg tcgtctcagt ttagtaccta 129360
taactatcat cattcttttg gtggctatta caatgttggt aaaagaataa aactacaaca 129420
catctgttaa taatcaactc gctcgattga ttgtcaagaa tgtttagtga tgagtatgtt 129480
atttaaggca ctcgagttgt gattgagttg gatccattgt agtttacggc tatataagtc 129540
ctcaataata cgctctatac gcaaattcct attatctgtg aaatgtttaa cgcgtacgct 129600
aactctataa aatacttaac tatattatac gttagaatat cttaacggac aatcgcattg 129660
tatttatttg tatagattaa tgaaaaagta ggtgcgaata ttgtaggtat ggtaaaggcc 129720
ggtaagtaat tctagccttc atggaacgtt atgttttaat ttgaaattta agggatagtg 129780
cgtctaaatc gttaataaaa ttagttgaaa tcacctagtt agaatctgta aaaattcacc 129840
ataaaagttc caccgtaaat taatgattac tactgtataa ttccaaaatt tactctctta 129900
agttaattaa accaatctgt ttccctaggc ttctataaaa tagcgtcggt aattttcccg 129960
catggagaca gatgttattc ggaaataaaa atttacaaac ttctttggca cttctgctga 130020
caacagtttt gtttatacta ttcttgtcat gatgtagata cgacgcgtta ttatcatgtc 130080
gaagttcata ataagtgtca ttttaccata cagaccatga ttctgaaagt actgacaagc 130140
tgcaaatatg aaattcatat ttctcatcac aaggctacag acctctaata agatgtacgt 130200
taactgagat tcgtgtcggt agaaccgaac gatcatgtaa ctttcactat atgagttgac 130260
ctgctttgag ctttccttta tactaactgg tattctggcg aaacaaagct gtagcagaat 130320
catgtcatga gtattaatag tagtaagaaa atcacggata atgttacaac cgttttctta 130380
tttagaggta gtgtgaagaa cttttacatg aaccagcaaa ctaacatctc tttcaaatta 130440
ctactcatac aataagttcc gtgacgacat gactatctca acctgattta caattaatgc 130500
tcttatattg agaagttatt aagcgagata tgcatttaag gataatagac acatcacaaa 130560
ttgcggatac cattgagaca ttttataaat agatgcaata tggaatctta tagaattgcc 130620
tgatagcgtt atattgatga acatgactaa ttaccctttc acccacgcta ttagcttcca 130680
taccatttgc ggccattcat taagatccgt tgttccttac aaaaaaaaaa ttaataagaa 130740
attccgtaac atgcagattt agtagttatt ataaacaact ttactggaac aaactaaaac 130800
atttataaac agaattttga tagtggcaat taatttctaa tgatgtgata ttaaggtcta 130860
aaatgtaaga attcgataaa ttagattaga caaggggatc cgaagatatt ttagcgcagt 130920
tagttatagg gggaacctct gcctacaaaa agcgtttatt gttaattgtt taaagataca 130980
gtgaaaacga cagtcgttaa aacaaaaatg atatgtacaa tactacatct aagcagcgca 131040
ataacgcaac agcttgaagt atttttcaca gaaaaatcgt acgtccagtt ctaacacttt 131100
catatgtgtt cgtcgtttat gcttttagta tgaaaactag tgtgccggtg tctggagatc 131160
atccttcttg catatgactc caaggacagc catcatggtt tgtaagttca ttgagactgt 131220
tacgcttaac tggacgaaac tcgagaagat atatgattga tcgtaagacc gctttgattc 131280
gacaccatca taacacagta ctcatgatta tcatcatttt tttagtccct attacaaagc 131340
tgccaagtga ataaatctct atcacactct atgaaaatgc acttgatcgt tttattgtag 131400
aaaaaattta ataaacagaa tgttaatgaa ggcactactg tactaataga gttgggctat 131460
atgttaacta caagactata acttattaat aactcggtct atacataatt tggtatcatg 131520
tatgtagtgt tcaagggcta tagcaattct gataaaaatt tattaaggta acaccttaga 131580
ataatatact ggtctatcgc aatacaacca cttctaccgt ataatccgag agtggccacg 131640
ataatcgaag gtatggtcaa ccgttgtaag taattctagg cgataaggaa tccttttttt 131700
ataaattttc tttaggacat tgttcacgta aattatcaag attaattgtt gtaatgagct 131760
cgtttgattt tgaaaatttg tgtcttaaat tcgtctccga ttaatacact atactatact 131820
ttaatcccag atatatcaat attaaactat ttaatttaat ctaatcctca aaccttctat 131880
taaatcgtgt caatcaatat ctgcttccta aatggaagtt tttcgccaaa aacaataaac 131940
agaatttaaa gtcgcttttg tcctcagcaa ttttgttttt tttatacagg ttataacgta 132000
gattcattcc gttaaagcgt tgtccaattg gataaaaaac atctttttaa tctccaggtc 132060
aagtttgtga aagtaaacac gtcgagcaaa tacgtatacc gcacatttga ccacgcagcc 132120
acatacctct ggaaggaaaa acacatacta acctacctga cgctagtgca aaacattcaa 132180
gaaactctga caatgcgaat taacgagcct taaactcttt tatttgctga taagcattat 132240
tgcgaaacta gcttgagctt gtattgtctg gtgtgtacta ttagaagtga aaaaatcagg 132300
gttaatgtct cgtcgcctca tttatataca gatagtcagt gatacctaaa cgtatactag 132360
caaaatgaca tcttaattaa attatttatc ttacatattc ttcctagatg acatgaatat 132420
gttggtccga tgtataattg atgttctgat ataggataat aactgaaaca catatgtatt 132480
ataccaaagt atgtacatca caagttccca atatcgttta gactactatt tactaatccc 132540
attgtggaat cttaatatat gatcggatag ccttgtgttc gtgaaaacgg catattaggc 132600
tcacagcggt gctattacct tccataccag ctagcaacaa cgataatcat ccgctattgg 132660
ataggaaaat agtatttaaa agaaatcttg taacaaatgt tttatatagt cctaattaac 132720
tacattactc gagcgaacta aaacttatga tcacaaaaat aaagctgagc ctaattatgt 132780
gatatgattt aaaatttcgg tctatatagt tataatttga tgaaataaat tggattagca 132840
gtttgctaga tgatttggca cagatagtca tagacgaagg acttactatg aaatagcggt 132900
tttagttgtc aatgttggat ttcagcgaaa gcaggaatcg atgtagctaa agaaatatgt 132960
ccatcattgc atttagataa ggcatcttgc caaaaagaga accaatattt tgtaaagaaa 133020
ctagaggtcc tctttatact ctatgatttg tgcagctctt aaatgcaaac gacgagtaaa 133080
caggtgcgtg ggtgtatgga gaccttcatt tttatgtatg attggatgga ctacgatcac 133140
attttatggg ttctctgcga ctgtcacgct aaattactcg gaaattgaca atgtaatcga 133200
ctacttgtaa taacccactg atcgaactgg agcataacgg gtcacacatc ataattttca 133260
ctattttagt ccgaattatt cagcatcgca gtaaatgtat aacaatcggc cactgtccat 133320
ttacatatca tcgtattcca ttagaattaa tttaatatat agaatgtgta agtaggatct 133380
actgtactta tatgaccatg ctacatatta acatgaaaac tatatccaat tcttgacctt 133440
gtgtatatat aatatgaata cgaacatgtt ggattcaaaa gttatagcaa atcccatctt 133500
aaatgtttag ggaaaggctt tagtattata ttctagccta ttggaacaca agcacctttc 133560
ccatgtaaac ccagtgtctt caccataatg aatactttca tcgatcgtta ttgcttttag 133620
tacatgatga ctcgtccttt taacataaat tttctactga atattcatta caaaatgtac 133680
caggattaac caatgtaatg agcccccttg attttgggta ctggtgattt tatttcgact 133740
cagatttaca cactaaagta aattttaaag ctagacatac aaatattaaa gctctctatt 133800
taacctaaac gataaacaat cagctaaacc gtgtcttact gagtctgctt cttgaatgat 133860
actttaccgc caaagtcaac agttactacc taaagtcgct ttgatctttt gctacaccga 133920
attctttatg aagagagtaa cgtaaatcta ttttgtagaa cgattttttt ctaggtcatg 133980
aaacatttcg ttcatctcta agaaaattat gagacattaa acaggtcaag aattttcgtt 134040
tgctcctcat tagtccacgc acccattttc gtttcgatgt aaaaattcat attagtctat 134100
ctgatgctaa tctaatatac cctagacacg ctgacagagc cattatgtga gccttttact 134160
gttaggttag gtgttgttcg atactgggtg actagcatta cctcgtattg cccagagtgt 134220
ggtatttaaa atggtcaaat taggctctaa aagttgtaac gccatctgca cattgttggc 134280
tggtgaccgg tagatgtata ataatataag gtattcaaaa ttgaattaaa tatgctttgc 134340
gctcatccta catgagataa atatagtgga acgatgcata attctacatt cgattcaggt 134400
tatgaacagg aactcgtatt taaagttttt atcgttcaaa aacctaagtc ttcaataacg 134460
ttttgggtgg gatttgcaaa ccccttacca aaatcgtaat ataggattgg ataaacttgt 134520
cttcgtggta agggtacaat tgggacgctg aagtagtgta acttatgaga aaggctaatt 134580
ataacaaaaa ttaaattcta gtgaggtgga agattgtatt ttaaagatga ctaataaata 134640
ttgttataca tgctcctaat cggttctacg gctcgcgggc accaaaaccc atgacctcta 134700
aaataaagct gagtttagac gcgtgatttc atttaaaatt tcaatctgtt tgtctattat 134760
atccagagat atactgcatc tcctattagt ttatcgattt cgcatacaat gactcagaca 134820
aagaactcac tatggaatcc gagaatcagg tgccaatgat cgttccgatc aaaacatgaa 134880
agctatgtgg cctgacgaat acttctctca ttgtttttag ataaaagatc ttgctgaaat 134940
aggatccagt actttgtaaa gcaagttgag aatcttataa tgttttgaag atcatcgggt 135000
tctaaaaacc aaacgtggac taattaggtg cgtgggtaaa aatctagcta catttctaag 135060
tagtttcaga taaattatga taagtttata tgggatgcgt acgccagtct gcataatact 135120
ttgagagaat gacaatccaa tctagatcaa gctatgaatt acaaacggtt atgaagtaaa 135180
acgggtgtta cagcttaaat ttagccagaa taatttagga gtttcaacat tgccgtagag 135240
gtgtaacaac tcaccagtgg ccatccacat attaatatat tccataactt ttaactaatt 135300
ttatttgtaa cgcgggcaaa atatattttg tttaagtctg cttgctacga tcttagacat 135360
aagcttggtt caatactcgc gcttaaagaa aaatttcaaa aacagcaagt ttttggactc 135420
tcaaattgtt acaaaatgca ccctgtacgt taggggaatg gttactactt tatatccatt 135480
cttgtttaga cagaagcacg attcccatgt taatcctcca acttcattac attgaatata 135540
cgttcccttt aattttctat ttgatttaag gtcattccat catctaacac taaatttcta 135600
ctgattattt ataacaatat gtaggaggat taggcaagat gcgaaatgct ggttgttttt 135660
ggttctggac attttatctc gaattaaatc tgcgcattaa tatgaattct atagattgac 135720
aagcagaaaa cataggtctc tttaagacaa tgggaataat taaataccta gagcataaat 135780
tactgagtaa atatcttgac tcatatcata gattcctagc ccccggttgc taggaaggtt 135840
agtcttgtag tttccataga ccagactgct aaagaagaga gttactgata tctttttttt 135900
agggcgacgt aatcctagat gatgattcat atggaccaac acttagaata ttacaaatct 135960
tctagttacc taatattttt gatttgcacc tgggaaatca ttgcattcga ttttagatcg 136020
gtgtaaagat tgatcaaact ccatttaatt ttatccaaat ttaccatatg catgggataa 136080
cacgtattat gaaattcact tttcgttagg ttacaactag ttcgagactt attgtttgct 136140
aatactacat tatcctcaca ttagcgaatg taattggctc tctaaaaatc ctcatagttg 136200
taatgggaag ccgagattat tgagtgatca ccagtagctg tactatttta taagctatta 136260
aaaattgatt aaaataaaca taccgcctgt aatatataaa tcatagtcag acgaacattg 136320
ctacaatctg tattcgtacc aagttatgag cgcgtatttc ttatttaagt ttttgtcgct 136380
cacaaaacac tgggtttacc aatcattcac atgggacatg cgatcgtact gcctatgatg 136440
atatattggt aagaagttat ctgtctttct tctaagagag caattaaaag gttaaagaaa 136500
tgcaatatat atgcaaggga aattaatgga taatcttaat tcctgtaagg tagcacattg 136560
tgacttaaaa atgactaaat aatattgttg tacatctagc taatccgttc tgggctttac 136620
gaccaacagt aacgaagacc tattaaaaag accttgatat ggacgcgcaa ctatagttaa 136680
gttacctaga tgtccgtctt ttctattcag ccaaattctc ttaccttttt caatctttgg 136740
atctcataat taatagctcg tttatagaag agtatatact atctaagggt ggagggccaa 136800
ggatccttcc aatcacaaca tcaaagatat ctggactgac gttttctcct ctcaaggact 136860
atagaaaaaa aatcccattg cattaggatc taccacaaag attacctggt tgtaaatttt 136920
gcaatgttaa gaacatcaat ggatcataaa aataaaacgt gcatccttta gtaacaaaat 136980
ctaagatcta gacaaatttc caactagtct gaacttagat taaagaggtt taataggtac 137040
acgaactctg tcgtatatat tactttaagt gaaatgtttt ccagtgttga tcaatctctg 137100
aataacaaac gattataatg aaattagagt gtaaacgtta acaacgaccg agagattttt 137160
agcagcatca tagttacctc tcggctctag tatctcacaa atggtcatcg atttgataaa 137220
ttgctcgata atttctatgt actttcattt gtatggcgga ctttataaat ttagtatcag 137280
tctggtttaa acgatgttga gcataagtgt gcttgaaaac tgccacataa agggtaaatt 137340
cgaaaacaac gagtgttttg tgaaccatat gcataattag agtaccctgt acgctagcat 137400
gacacatgcc tccacaaagc tattcttcaa tacagtataa atagattcat tcgtctattt 137460
ttctatttat atgcgttata tttacgttgt ctttaattac ctgctagaat taaagacatt 137520
ccattgtgta ggactgagtt ttcagtaatt cattatatta acttgaagac caattaggca 137580
agacccgaca agttggttgt gaatgcctcc gaataattct tctaaaacta tgcctgggtg 137640
ttgacagcaa tccattgaaa cttcaggcag aaaagcttag ccggtttaag tgaatggaaa 137700
aacttagaag cgttctgtat tgattatcga ggaaatattt tctcatttgt gacagatttc 137760
cacctcccgg ttcttaggaa ggttaaaggt gtaattacta ttgacgtgac tgcagaggag 137820
aagagatctt gttttcattt tttaacggta acgtgatcct gaatggcgtt tataatggag 137880
caatatattt aacgtcggaa ttcttgtagt tatctagtat ttttattttg tatataggag 137940
ataataattt tacattcaag atttgtttca tgcttaatca gtcttgaatg taatttctct 138000
aaatcatcca tgtgccagag acagcatatt taatgaaata aactttacaa aaggtcataa 138060
ttagttaggg agttatcgta tgttaatatt actctgatct gatatttgca atcgctgctg 138120
tctctccaat attcgccgta atatcaatag agaggcgaga tcatactgtg ttttccaacg 138180
gcaagtctat ctaaccagtt attagaggaa cttgatagca gacataccgc ctgaaatatt 138240
tacatcttag tcagattaaa tttactacga ctcgtaaaca cacgattttt tggcagtgta 138300
tttcgcatat aagcttttgt tgcttacagg acacttggta tacgtaatga tctcatgaga 138360
catctgttca tactgtgtac cgaggtgttc cgataaatag ctatgttata tttatctata 138420
taagccgata aaaagacaaa tataggcatt aaaaatgcaa caaatattaa tgaacggtct 138480
caattagtga aaggtatcgc tccttggccc atatctcaaa aagcgatata ttcgaactac 138540
tgatgaagcc catcagggct gttctatcta gacttacggg agcttatttt gaggtttttg 138600
ttacggaccg acaaccgtcg tgacgtaact ttgaagtccg tctttccgga tcgaccgaat 138660
tggttcacct ttttgaatct tcgtaggatt atactaatag ttgctttttg taaaagtaaa 138720
cactccctat aggtggtggt ctatgagttt ttccattatc cttattattg ataattctac 138780
tcatgtcacc tctactatag tacaaattta ttatactacc attgcactag atcttacggc 138840
gaatactctc tcattacata aattggagcc tcagggacat caatagatga taaatataaa 138900
gtttatgtcc tcaattgtaa aattgtaagt tcttaacaaa gtacgtatta gtcagaactt 138960
acattaatga cattaggtat ttacacagtt tctgtgatat agattagttc atttcaaatc 139020
tttttccgta ttagttaatg cctcaataga atagaattat aataacacta tattataaac 139080
gttagcgacg acagagaggt tgaaagcggc attctagtaa tctgtccgtt cgagaacgat 139140
ataaaatgtt cccgtacaga ttgataggtt agtattctcc ctgagctgtc gtctccatga 139200
cggactttat agtagtacaa tcgctttaat ttaatacatg gtcagcattt ctgtgccaaa 139260
aaatcgtcaa ataaagcgta tatccgaata caatgaatgt gctatggacc ataagcatta 139320
ctagaatact ccgcagacaa ctatgtcata aggctccgcg acgcaattta acgatactat 139380
atcaataaaa ataatcagct atttttctgt ttatatcgct aattcttacg ttgattaata 139440
ttgcttgccg gagtttatca tcttttatag ggaggaggcc cgtagaggat tttacggtat 139500
ataagcctaa taacttctac caatggtgcc gtcaaaatag atcagagtat ccagaaataa 139560
aactccaata agaatggctg acactaggca gcacaggatc gaaacttacg ctacaaaggc 139620
ctaacagact gaaccaagtg gaaaaactaa gaagtatccc aatatgatta actgtgaata 139680
agatattcat tcgtgaggaa tatccgtcac cacttactca aaaccgtaat aggaataata 139740
actattaaaa tgaggacagc gtacataatg tcatgctcga ataatatggt cgtatggtga 139800
actagaatac ctcctatgag aaagttaaga acttaacctg ggtgtctctg ttcatatctt 139860
ctatttgcat ctgtaataca ggagtcaaca tattaacaca caagagttct ttcttccata 139920
tgcagttatg taagtcattg ctgtattcca taaacctgtc aaagtcacta tatctggtta 139980
tgtaaagtct agagaaatgc atagtcattt atggaaatat ctcaactaag tataattgtg 140040
ataaaatgta tgtagtggct gctgtttttc caactttcac cgtgagatga ttaaacaagt 140100
acactcttgt tatttattat aagctcatgt gtaactaccc tatcacaaga gcgatccgac 140160
aggtgaagca ttaacaggaa actcatcacg tcagcgtaat taaattatac accagtcgta 140220
aaatcgcact ttattagcag tttaacatgc gtatagtcta accctacata cacgatacct 140280
gaaaatcgta atgaacttag taacggatag ttaaaacggt attccgaagc ggtgcattaa 140340
ttcgctaagg tatggttgtt cttattacac ggcttagata caattatagt ggcaaggaat 140400
acaattagtt attaccaacg gcgacgaata gtagtttatt tccttcctgc gggctcctcc 140460
tgaaatgcca cttatacggc ttattgaagc cgattagtac aatagattta ttcaacctca 140520
aaggtctata ttcccggctt attcttagct gatatgtcgc gtcgagtccc gggtttgagt 140580
gcgttaacac cggattgtct ggcttagttc aacttttgga tacctcatcg ggttatacta 140640
actgacactt attctttaaa taaggttccc ttattgggac tagtaactga gatttgaaat 140700
tatccttatt tctaatgatc ttaactcttt cgcatgaata acagtacgag cttactttac 140760
gaggttatca cttattcaag tgcaggatac tcttccaatt cttgaaaagg acgtagagag 140820
ttgaatgtat tagatgggcg tacgcattat gtgctcactt gtataattgt gtgttttcaa 140880
ggaaggaagt atgcatcaat tcgttcagta tcgacataag gtatttggaa agttttagtg 140940
acatagtcca atagattttt gatctcttta ccgatcagta aataccatta tagagtcaat 141000
tcagatttac gctatttaac acacaacgcc gaggataaaa gggctgaaat tgacagtcta 141060
caatattgtt catgtgtcaa caattaacaa taaacgaata cacgttgatg cgatagtgct 141120
ctggctaggc cgtccacttc gtatattttc tttgagtagt gtagacgtat taatatagca 141180
tgtagccaga ttcttagcat gaaacgatga ttaaaatgta cgcataccac gttgagatgt 141240
atgtgctata gacttttagt gttacctgaa acatagtcca tcgattttgc cataagacta 141300
cggcacgaaa ttaagtgatt tcacacctac aagagaaatg tgccgaatct atgataataa 141360
caccgttcgt tgaattaatc aataatggta gcggttgcat attatcaaat gaaggagcca 141420
cacccgggga ggagtttacg gtcgatatcc cgtacaactt cggctaatca tgttatctaa 141480
ataagttggg gtttgcagtt gtcagggcga aatcagattc gactatacag cccagttcag 141540
agccctaact cacgtaatcg tgaccttaca gagcgagtca agttaattac ctatcgagta 141600
gctcaatatg agagagtgtg aataagaaat ttattgcaag gcaataatcc taattattga 141660
tagcaaactt tgataagaat aaagaatagc acaattcaga aagcgtactt actgtcatac 141720
tcgaatgaaa tgctttatta aagaaaaagt tgacgtccta tgagaagatt aagaacttct 141780
cctgcatctc acaacctact taatcttcgg ggatgggtaa tagataggtg aacatataaa 141840
tagagataag tttctacctt caaacgtagt taaacaagtc atagctatat cccacaaacc 141900
tttcataatc actgtatcgg gatatctaag aagtaatggt atggctagtg atcaatcata 141960
atttgtcagt taagacaaga tgcggtaaat tgtgtattgc gagtcctatt gtctcgactt 142020
aaactgtctg atgttataac aaatacacag tagttaattg tcaattgctt atgtactgct 142080
acgccttgtg gagaccggtc cggcgcgtga aggatataaa tgaaactcgt cacatccaca 142140
ttattatatc gtacatcgga gtacgaatcg aacttggcct ctatttttag atgcgtgcgc 142200
tgcaagtgta aatgtaccaa atctaaaaat tacgatgggt tttgtttcag gtatccaaaa 142260
agtaattctg atgccgcgct tcaattcact aaagtgagga tgttgtcttt atacgggttt 142320
gatactttta ttgtaccaag catctttatt agttagcact atccccaacg tataacagtt 142380
tactttctcg gtgtgagccc ctcgtcaact gcctgcagta gtgcacgttg aagccgatta 142440
gaatattaga ttttttcaac tccaaacgtc aacagtcccg ctctagttta agttcatata 142500
tcaggacagg tctcggaatt aagtgtataa gcgctgggaa ctttcgcgca gttcgaatag 142560
tgagtaagtg atcgagttac acaccgttag attcatcctt cagataacgt tccgtttttt 142620
tgatttataa ctatcgtttg aatcaattcc atcttcttaa cgtgttaagt catccgcaaa 142680
aaagacgata tgagcttacc ttacgaaata atttcatttc gaactacagg gtgctctact 142740
tgctcttgaa gatatcgtag agtgttggat gaattaaaac cccctaccca ttttcaatcg 142800
acttgtatgt ttatccttaa actaacatgg aaatttgctt tgatttgttt agtatcattt 142860
aggcgtgttt caaatgtata attaagtatg ccgcatagtt tctccattac cgaactgaac 142920
accacttagt gtcaaacact cattgctgtt ctacgccatt tatgacatta cgctcaaatt 142980
aactgagctg aatttcaaag actataatat tatttttgtg ttaccaatta acagttaacg 143040
aatacgtgac gatgtagaac accaggagcc aggtcggacg catcctatat ttacttcgtg 143100
cagagtaggt ctaacaagat agcatggagg tttatgctta agttgaaccg cagataaagg 143160
tctatactcg ggatcttcac tatctgaagg tttagaattt taatggtacc ctatacaaag 143220
tgcataggtt tttcattaat attaagacgc aaaggtaagt gaattcactc ctacaacgga 143280
aatatgacca aagtatcaaa acaatatggt tcgtagaaaa aatcgatcgt gataaaggtt 143340
ggattttgac aaaacaaaga gctacagtct gggaacagtc gatggacgcc accacgtgct 143400
ttttcggcta atcttataat ttataaatgt tgaggtttag aattctcggg acgagatcaa 143460
atttaagtat atagtcatat ccgaagcgtt aaatcactta ttcgccatgc ttaaaagcgc 143520
ctcatgcttt tcactgattc attagctcta tgtatggcaa tctatgtacg aagtctgtcg 143580
taagacttaa aaactaaata ttggtagctt ccttagttaa agtacaagga ttgcacaatt 143640
cagtagacat tttttctggt attcccgaac ggaaagcttt attaagacaa agtttgatat 143700
ccgacgggat gaaccacaag ttctatgata tctcagaagc tactaaattt cgggggttgg 143760
gtacaagtta gttgaacata caaattggaa tttgattgta tccttggtcg attctaaaca 143820
aatcgtagta aacccgtgca aagtatatat attatttcat acggcgtttc aaagaggcaa 143880
tggcttgaca tgagctggat ttcagattat gagtaaccac aagatagtgt aaacactgta 143940
atccatattt aattgagatc tcttaaaaat gctgatatta ttttctaaac tcgatggttt 144000
attgacaatt atttgtacag tgatacatct agcggttctt ggtcgaccct acttacgtaa 144060
taaatgtagc acgtttgatc cagactcatc catggtagct tcaaatacgg attcaacttg 144120
gcgtttatat ccagaaaacg gccctagagg tgatagacat ttaacacttt ggacaaccat 144180
tggatatgtt tcacgtatcg atatagtaat tattattctg catttgcttt ctagtaagtg 144240
aggaagaagc ctttctattg gtttcttaat cctcttatac cacgcgtgta tctttcctag 144300
ccctttattg aaactggaag tgtcttgtta ttcaatgtta aacccttgtc agcctattgc 144360
ggtgatgcac gaaaaaacca aatggaatat aaaatattaa ctactcctaa ttttaagtgc 144420
cctcttctag attgtattca tatatcaata tagacttcgc aaactagtga atgagggaaa 144480
tgaatttatc cggaataaca aaagggactg agtattcaag atacaaaccg ttagatagat 144540
gttccagtct gcatagtaaa tttttgtttt ttaaccattg aaggaatcaa tttcacgatc 144600
cttacgagtt tagtcatcag aaaaagagac ctttagcgct ccccccttga aatagtacag 144660
cttcaaacaa taacctgagt aagttggtat ccgaggtact ataaattttt cgatcatttg 144720
atgcccccat cctatgttta aagaactatt atctttagcc ttaagcttac acaggaacca 144780
gctgagtcta ggttaggttc acttgggttg cttacatata taaaataatg tataccgcag 144840
aatttgtccc ttagggaatt gtagttgacc aaaagtctat tactcattgg cgttgtatca 144900
cttttgtgtc aataggtatg atcaatctct tggaaattat tacgatgttg gtaaaagatt 144960
agaactacta aacaactgtt aataatcaag tcgctccgta gattgccaag aatcagttga 145020
gatgaatacg ttatttagaa cgtacaaact acgattgagt tggtaccatc gtagtttatg 145080
cctatgttaa tccccaatta tacgtctttt gcccgaatcc ccactatctg tgaaatgttt 145140
aacgtgttcg ttacctttac aaaatacata gctatatcat acgtaaaaat atcttaacgg 145200
aagatcgtac actctttctt cggatagata agcaaagaaa taggaggata tggtgcacac 145260
atggaaaggg ccggtaagta attctggcct tcatagaaca atatgttata atttggaaat 145320
tgtcggatag cgcgactatg tgcttaattg gtttacttta aattttataa ttgatgacaa 145380
taaaaattca ccggagaagt tctaacgtaa gtatatagtt ataactgaac gattccaaga 145440
tttactccct taagttaatt agacctattt gttttccctg actcctaagt tttatggttg 145500
gcaatttatc tgcaaggaga cacatatcat ttagaaataa aaaattggaa acttctttag 145560
ctgttgtgct gggaacgctc atatcaatac ttttcttctc tagaagttga aaggggggaa 145620
tattatcatg tcgaagtttg ttataagagt cattctacca tacacaccat gattctgaaa 145680
gtgctggtaa actacgggaa taagatacat atttctcatt attagaattc agacctcaaa 145740
tgagtcgttg gtcaactcag atccgaatcg aaagaaccca acgaatatat aacttttatt 145800
acatgtgttg tcttagtcag agtattcctt aacattaact ggttttcaga cgatatgtaa 145860
ctgcagcaga gtcaaatcat ggatattgat agtagttaga gaaccattga taatgttaca 145920
accattttct aattttgatg ttgtgtagac aattattagt tgagcgagct aactaacagt 145980
tcttacaaat ctctactcat acaataaatt ccgtgagctc aacactaact caacctaggt 146040
aacatcaaat gccgatatat tcaggggtta ttatgcgaga tatgcgctta gggataatag 146100
acactttaca aattgcgcat gcgatcgaga tattttatga atcgatataa tatgcattct 146160
tatagaattg cctgttagcg taacataaat aaacgtatct aattactttt ttatccacgc 146220
ttattacatc cgtaccattt ccggccattc attaagatcg gaagtacctt gcaatacaaa 146280
attaaacttt aaatacccta tcacgcagat ttagcaatta ttttaatcaa ctttagtgga 146340
tcaatcatag acatttttaa gtggtatttt caaggtggca tttaaatatt aatgatgaca 146400
tattaaggtt ttaaatgaga gaattcaatt aatttggtta gacaaaggga tccgaagata 146460
ttttatcgca accattaaaa gggcgtacct ctgtctacaa taagccttta tttttaaatg 146520
tttgaagaaa tcgtgaagac gactgttgtc aatacaaata tgataagaac agtactacat 146580
ctttgctccg caataatagt acagcttcaa gtaatattca cagtaaaatg gtatgtctgg 146640
tactaagact ttcatgactg ttcgacgttt atactttaag tataaagagt agtgatccga 146700
tgtctggaga ttattctaca tccaattgac tctaagcaca gccttcttgg cttgctagta 146760
cattgaaagt gatatactca actggacgag actcgaaagg aaatatgatt gaccataaga 146820
ccgctttgtt tcgacatcgt cttagtacag tactcataat tatcatcatt cttttagtgc 146880
ctattacaat gttggcaaaa gaataaatct ccatcacact tcttgaaaat gtacttggtc 146940
gtttgattgt tgagaaagtt taatgatgag tatgttattt aaggcactgg tgtactgata 147000
gagttggact aaatgttaat tacgagtata taactcttca ataattcgct ctatacgcaa 147060
attcctatta tctgtgaaat gtttaacgcc tatggtaact ctgtaaaata tttatctacg 147120
ttatacctta gaatatctta acggactatc gcaatatatc tacttgtact gattaatggg 147180
aaagtaggtg cgataatcga aggtatggta aacgccggta agtaattcta ggcaacaagg 147240
aatgttattt ttttaattat tttttaaggc attgtacgtc taaatcatca ataaaatttg 147300
ttgaaatcac cttgtttgat tttgtaaaaa tttgtcttaa aactatcacc gttaattaaa 147360
gattactaca ctataattcc agaatttaca ttcttaagct atttaaacta atctgtttcc 147420
ctaggcttct ataaaatcgc gtcagtgatt atcccccttg gagacggatg tttttcgcaa 147480
ataacaatta acaaatttct atgtcacttc tgctgtcagc aattttgttt ttactatact 147540
tgttatgatg tagattcgtc gcgttattgc gttgtcgaac ttcataaaaa gtgtcttttt 147600
accatgacca cgcgatataa accccctata tacttggtgt cactctacta gttttatact 147660
tacttcgtgc taattcaaga aatcggtttt gtctcaattt atttgcattc agccgtcaat 147720
acagtatact ctaatgaaga tgactaaacc ttcaatgctt aggcgtgctc taatatagtt 147780
aaccgctatg tcagtctcat tttgtatctc taaaattggg cggtaacata catctccgtc 147840
ttcaataacg acttcttata ttgtattaaa gtcttttatc gtgtatatgt aagccagtgc 147900
gatttctcaa gtttcatcgt ctcactgctc ttctcaaatt gttcgctaat ttggcacata 147960
gtagtaagaa aatcagggat aatgttacaa ccgtttactt atttagaggt agtgtgaaga 148020
acttttacat gaaccagcaa actaacatct cttttaaatt attactctta caataagttc 148080
cgtgacgaca tgattatctc aacctgattt acaattaatg ctcttatatt gaaaagttat 148140
taagcgagat atgcatttaa gcataataga cacatcacaa gttgcggata ccattaagac 148200
attttataaa tagttgcatt atggaatctt atagtataac ctgatagcgt tatattggtg 148260
aagatgacta attacccttt cacccgcgct attagcttcc ataccatttg gcgccattca 148320
ttaagatccg ttgttcctta cgaaaaaaaa attaataaga aattccgtaa catgcagatt 148380
tagtagttat tattaacaac tttactggag caaactaaaa catttataga cagaattttg 148440
gtagaggcaa ttaatatcta atgatgtgat attagggtct aaattgtaag aattcgataa 148500
attaaattag ataaggggat tggaagatat tttagcgcag ttagttatag gcggaacttt 148560
tgcctacaaa aagcgtttat tgttatttgt ctaaagttac agcgaaaaca gcagtcgtta 148620
aaacaaaaat gatatgtgca atactacatc taagcagcgc aataacgcaa cagcttaagg 148680
tatttttcat agaaaaatta taggtccagt tcaaacactt tcatttgtgt tcctcgttta 148740
tgcttttagt atgaaaacta gtgcgccggt gtctggagat catccttctt gcgtatgatt 148800
gcatggactg ccatcatgtt ttgtaagttc attgagactg ttacgcttaa ctgcacgaaa 148860
ttcgagaaaa tatacgactg ttcgtaagag cgctttgatt gaacacgatc ataacagagc 148920
actcatgata atcatcattt ttttagtccc tattaca 148957
Claims (19)
- 하나 이상의 샘플 중 전사물 변이체의 조절된 식별 및/또는 정량분석을 위한 방법으로서,
a) 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 특히 적어도 5개의 상이한 핵산 (NA) 분자 그룹을 포함하고, 이때 각각의 그룹이 적어도 2개, 바람직하게는 적어도 3개, 보다 바람직하게는 적어도 4개, 특히 적어도 5개의 상이한 NA 분자로 이루어지는, 전사물 변이체를 모방하는(simulating) 인공 NA 분자의 참조 세트를 제공하고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 모든 NA 분자가 동일한 인공 유전자의 참조 전사물 변이체이고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 NA 분자가 적어도 80 뉴클레오티드(nt) 길이의 서열을 공유하고, 상기 각 그룹의 적어도 2개의 NA 분자가 적어도 80 nt 길이의 적어도 또 다른 서열만큼 상이하며,
여기에서 상기 NA 분자의 적어도 2개, 바람직하게는 각각이 소정의 몰량으로 존재하는 단계; 및
b) 상기 참조 세트를 외부 대조용으로서 상기 전사물 변이체를 포함하는 하나 이상의 샘플에 가하는 단계; 및
c1) NA 서열분석을 리드 생성(read generation) 및 할당(assignment)을 근거 로 수행하고, 여기에서 참조 리드 할당이 상기 참조 세트의 리드에 의해 생성되고 상기 참조 리드 할당을 사용하여 상기 하나 이상의 샘플의 전사물 변이체의 리드 할당을 조절, 확인 또는 변형시키는 단계; 또는
c2) NA 검출 또는 정량분석 방법, 바람직하게는 마이크로-어레이 분석 또는 qPCR을 상기 하나 이상의 샘플상에서 수행하고, 여기에서 적어도 하나의 탐침이 상기 참조 세트의 적어도 하나의 NA 분자에 결합하며 상기 참조 세트의 적어도 하나의 NA 분자에 결합하는 적어도 하나의 탐침으로부터 생성되는 신호에 기반한 측정 결과를 사용하여 상기 NA 검출 또는 정량분석 방법에서 탐침에 결합하는 상기 하나 이상의 샘플의 전사물 변이체로부터 생성되는 신호에 기반한 측정 결과를 조절, 확인 또는 변형시키는 단계
를 포함하는, 방법. - NA 서열분석 방법을 평가하거나 또는 NA 검출 또는 정량분석 방법을 평가하기 위한 방법으로서,
a) 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 특히 적어도 5개의 상이한 NA 분자 그룹을 포함하고, 이때 각각의 그룹이 적어도 2개, 바람직하게는 적어도 3개, 보다 바람직하게는 적어도 4개, 특히 적어도 5개의 상이한 NA 분자로 이루어지는, 전사물 변이체를 모방하는 인공 NA 분자의 참조 세트를 제공하고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 모든 NA 분자가 동일한 인공 유전자의 참조 전사물 변이체이고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 NA 분자가 적어도 80 nt 길이의 서열을 공유하고, 상기 각 그룹의 적어도 2개의 NA 분자가 적어도 80 nt 길이의 적어도 또 다른 서열만큼 상이하며,
여기에서 상기 NA 분자의 적어도 2개, 바람직하게는 각각이 소정의 몰량으로 존재하는 단계; 및
b1) 상기 NA 서열분석 방법을 평가하기 위해서, 리드 생성 및 할당에 기반한 NA 서열분석을 수행하고, 여기에서 참조 리드 할당이 상기 참조 세트의 리드에 의해 생성되는 단계; 또는
b2) 상기 NA 검출 또는 정량분석 방법을 평가하기 위해서, 상기 참조 세트상에서 상기 NA 검출 또는 정량분석 방법을 수행하고,
여기에서 적어도 하나의 탐침이 상기 참조 세트의 적어도 하나의 NA 분자에 결합하는 단계; 및
c) 임의의 단계 b)의 산출 결과, 특히 산출 몰량, 산출 농도, 및/또는 상기 NA 서열분석 방법 평가의 경우에, 상기 참조 세트의 NA 분자 중 적어도 하나의 할당된 리드의 수, 및/또는 상기 참조 세트의 적어도 2개의 NA 분자의 적어도 하나의 비를 상기 소정의 몰량에 비교하고/하거나, 상기 NA 서열분석 방법 평가의 경우에, 할당된 리드의 수 및/또는 상기로부터 계산되거나 예상되는 비 및/또는 산출결과에 비교하는 단계
를 포함하는, 방법. - 제1항 또는 제2항에 있어서,
NA가 RNA 또는 DNA, 특히 RNA인 방법. - 전사물 변이체를 모방하는, 인공 NA 분자, 바람직하게는 RNA 또는 DNA 분자의 참조 세트의 생성 방법으로서,
A) 천연 진핵생물 유전자, 바람직하게는 동물 또는 식물 유전자, 보다 바람직하게는 척추동물 유전자, 훨씬 더 바람직하게는 포유동물 유전자, 특히 인간 유전자의 그룹으로부터 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 특히 적어도 5개의 유전자를 선택하는 단계; 및
B) 각각의 선택된 유전자에 대해 적어도 2개, 바람직하게는 적어도 3개, 보다 바람직하게는 적어도 4개, 특히 적어도 5개의 천연 mRNA 전사물 변이체를 선택하고, 여기에서 각각의 전사물 변이체가 적어도 100 nt의 길이를 가지며 적어도 하나의 엑손을 포함하는 단계; 및
C) 적어도 하나의 엑손을 포함하는 상기 선택된 천연 mRNA 전사물 변이체 각각의 서열을 제공하고, 임의로 여기에서 상기 서열이 또 다른 NA 유형, 예를 들어 DNA 서열로 전환되는 단계; 및
D) 각 서열의 각 엑손의 서열을 대략 동일한 길이의 서열로 치환시켜 단계 C)의 각 서열을 하기에 의해 변형시키고,
여기에서 대략 동일한 길이의 서열을 바이러스 서열, 박테리오파지 서열, 그의 역전된 서열, 임의의 다른 역전된 천연 서열, 비-천연 서열, 및 이들의 조합의 그룹 중에서 선택하고, 바람직하게는 상기 대략 동일한 길이의 서열을 바이러스 서열, 박테리오파지 서열, 그의 역전된 서열, 비-천연 서열, 및 이들의 조합 중에서 선택하고, 보다 바람직하게는 상기 대략 동일한 길이의 서열을 바이러스 서열, 박테리오파지 서열, 그의 역전된 서열, 및 이들의 조합 중에서 선택하고, 바람직하게는 여기에서 상기 대략 동일한 길이의 서열을, 10개 이하, 바람직하게는 5개 이하, 특히 2개 또는 1개 이하의 디뉴클레오티드를 서로 독립적으로 임의의 다른 디뉴클레오티드에 의해, 바람직하게는 GT, GC 또는 AT에 의해 치환시키고/시키거나 10개 이하, 바람직하게는 5개 이하, 특히 2개 또는 1개 이하의 디뉴클레오티드를 서로 독립적으로 임의의 다른 디뉴클레오티드에 의해, 바람직하게는 AG, AC 또는 AT에 의해 치환시킴으로써 변형시키고,
상기에 의해 인공 전사물 서열의 세트를 획득하나, 단
상기 동일한 선택된 유전자의 상기 선택된 천연 mRNA 전사물 변이체의 서열로부터 획득된 인공 전사물 서열은, 바람직하게는 단일 엑손 서열 중에 포함되는, 적어도 80 nt 길이의 서열을 공유해야 하며, 바람직하게는 단,
단계 C)의 서열의 엑손 서열이 단계 C)의 서열의 또 다른 엑손 서열에 일치하는 경우, 상기 엑손 서열 및 또 다른 엑손 서열은 대략 동일한 길이의 동일한 상기 서열에 의해 치환되어야 하는 단계; 및
E) 단계 D)의 세트의 인공 전사물 서열 중 적어도 하나를 임의로 중복시키고 상기 중복된 서열을 상기 세트에 가하여, 단계 F) 내지 J) 중 하나 이상에서 선택적 변형을 위한 사본을 포함하는 세트를 획득하는 단계;
F) 적어도 하나의 서열을 상기 세트의 인공 전사물 서열의 적어도 하나에 임의로 삽입하고,
여기에서 상기 적어도 하나의 삽입된 서열이 단계 D)의 인공 전사물 서열 중 어느 하나의 동일한 길이의 센스 또는 안티-센스 서열과 일치하는 단계;
G) 상기 세트의 인공 전사물 서열 중 적어도 하나로부터 1 nt 내지 10000 nt 범위의 길이를 갖는 적어도 하나의 서열을 임의로 제거하고,
여기에서 상기 하나 이상의 인공 전사물 서열이 각각 적어도 100 nt의 크기로 남아있으며 적어도 하나의 엑손 서열을 포함하는 상태로 남아있는 단계;
H) 상기 인공 전사물 서열 각각의 첫 번째 뉴클레오티드로서 구아노신을, 5' 단부가 구아노신일 때까지 상기 서열을 5' 절두시킴으로써, 첫 번째 염기를 구아노신으로 교환함으로써 또는 구아노신을 5' 단부에 가함으로써, 바람직하게는 5' 단부가 구아노신일 때까지 상기 서열을 5' 절두시킴으로써, 또는 첫 번째 염기를 구아노신으로 교환함으로써, 특히 5' 단부가 구아노신일 때까지 상기 서열을 5' 절두시킴으로써 임의로 확립시키는 단계;
I) 상기 인공 전사물 서열의 세트가 GAA, GAC, GAG, GAT, GCA, GCC, GCG, GCT, GGA, GGC, GGG, GGT, GTA, GTC, GTG, GTT 중에서 선택된 5' 개시 트리뉴클레오티드 또는 AA, AC, AG, AT, CA, CC, CG, CT, GA, GC, GG, GT, TA, TC, TG, TT 중에서 선택된 5' 개시 디뉴클레오티드 및/또는 AC, AG, AT, CC, CG, CT, GC, GG, GT, TC, TG, TT 중에서 선택된 3' 종료 디뉴클레오티드의 필수적으로 랜덤하게 분포된 존재를 갖도록 상기 세트의 인공 전사물 서열 중 적어도 하나를 임의로 변형시키는 단계;
J) 바람직하게는 폴리-A 꼬리 서열을, 바람직하게는 적어도 10개, 특히 적어도 20개 아데노신으로 이루어지는 상기 세트의 인공 전사물 서열 중 하나 이상, 바람직하게는 전부에 가하는 단계;
K) 또는 바람직하게는 단계 E 내지 J 중 적어도 2개의 임의의 조합으로 수행하며, 바람직하게는 여기에서 각각의 방법 단계를 단지 1회만 수행하는 단계; 및
L) 상기 세트의 각각의 인공 전사물 서열의 경우:
상기 전체 인공 전사물 서열을 포함하는 NA 분자를 물리적으로 합성하는 단계; 및
M) 바람직하게는, 단계 L)의 NA 분자가 RNA 분자인 경우, 5' 캡-구조를 상기 RNA 분자에 물리적으로 가하고;
상기에 의해 전사물 변이체를 모방하는 인공 NA 분자, 바람직하게는 RNA 또는 DNA 분자의 참조 세트를 물리적으로 획득하는 단계
를 포함하는, 방법. - 제4항에 있어서,
단계 D) 내지 G), 바람직하게는 모든 단계를, 인공 NA 분자의 참조 세트가 진핵생물 유전자, 바람직하게는 동물 또는 식물 유전자, 보다 바람직하게는 척추동물 유전자, 훨씬 더 바람직하게는 포유동물 유전자, 특히 인간 유전자에 대해 자연에서 발생하는 선택적인 전사 사건을 모방하는 경우에만 수행하고, 상기 사건이 바람직하게는 하기의 그룹 중에서 선택되고/되거나:
선택적인 전사물 개시 부위(TSS), 선택적인 전사물 종료 부위(TES), 안티센스 전사물, 중복 전사물, 및 스키핑된(skipped) 카세트 엑손(CE), 인트론 유지(IR), 상호 배타적인 엑손(MXE), 선택적인 3' 스플라이싱 부위(A3SS), 선택적인 5' 스플라이싱 부위(A5SS), 선택적인 첫 번째 엑손(AFE), 선택적인 최종 엑손(ALE) 및 트랜스-스플라이싱의 그룹 중에서 선택된 선택적인 스플라이싱 사건들;
상기 인공 NA 분자의 참조 세트가 하기의 그룹 중에서 선택된 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 훨씬 더 바람직하게는 적어도 5개, 특히 모든 선택적인 전사 사건들을 모방하고/하거나:
선택적인 전사물 개시 부위(TSS), 선택적인 전사물 종료 부위(TES), 안티센스 전사물, 중복 전사물, 및 스키핑된 카세트 엑손(CE), 인트론 유지(IR), 상호 배타적인 엑손(MXE), 선택적인 3' 스플라이싱 부위(A3SS), 선택적인 5' 스플라이싱 부위(A5SS), 선택적인 첫 번째 엑손(AFE), 선택적인 최종 엑손(ALE) 및 트랜스-스플라이싱의 그룹 중에서 선택된 선택적인 스플라이싱 사건들;
상기 인공 NA 분자의 참조 세트의 모든 엑손 서열내 모든 인트론 개시 디뉴클레오티드의 적어도 50%, 바람직하게는 적어도 75%, 특히 적어도 95%가 GT이며, 여기에서 상기 인트론 개시 디뉴클레오티드가 각각 상기 참조 세트의 또 다른 인공 NA 분자 중에 존재하지 않는 서열의 5' 말단 디뉴클레오티드이고 이에 의해 상기 또 다른 인공 NA 분자에 대한 인트론을 나타내고/내거나; 상기 인공 NA 분자의 참조 세트의 모든 엑손 서열내 모든 인트론 종료 디뉴클레오티드의 적어도 50%, 바람직하게는 적어도 75%, 특히 적어도 95%가 AT이며, 여기에서 상기 인트론 종료 디뉴클레오티드가 각각 상기 참조 세트의 또 다른 인공 NA 분자 중에 존재하지 않는 서열의 5' 말단 디뉴클레오티드이고 이에 의해 상기 또 다른 인공 NA 분자에 대한 인트론을 나타내고/내거나;
상기 인공 NA 분자의 참조 세트가 500 nt 내지 2000 nt, 바람직하게는 750 nt 내지 1500 nt, 특히 1000 nt 내지 1400 nt의 평균 서열 길이를 가지며; 바람직하게는 300 nt 내지 1200 nt, 바람직하게는 600 nt 내지 900 nt, 특히 700 nt 내지 800 nt의 표준 편차; 적어도 100 nt의 최소 크기; 및 바람직하게는 10000 nt의 최대 크기를 갖고/갖거나;
상기 인공 NA 분자의 참조 세트가 25% 내지 55%의 평균 GC 함량을 갖고/갖거나;
상기 인공 NA 분자의 참조 세트가 GAA, GAC, GAG, GAT, GCA, GCC, GCG, GCT, GGA, GGC, GGG, GGT, GTA, GTC, GTG, GTT 중에서 선택된 5' 개시 트리뉴클레오티드 또는 AA, AC, AG, AT, CA, CC, CG, CT, GA, GC, GG, GT, TA, TC, TG, TT 중에서 선택된 5' 개시 디뉴클레오티드 및/또는 AC, AG, AT, CC, CG, CT, GC, GG, GT, TC, TG, TT 중에서 선택된 3' 종료 디뉴클레오티드의 필수적으로 랜덤하게 분포된 존재를 갖고/갖거나;
상기 참조 세트의 각각의 인공 NA 분자가 5' 개시 뉴클레오티드로서 구아노신을 갖고/갖거나;
상기 참조 세트의 인공 NA 분자 중 적어도 하나, 바람직하게는 각각이 상기가 RNA 분자인 경우 5'-캡 구조를 갖고/갖거나 적어도 10개, 바람직하게는 적어도 20개 아데노신의 폴리-A 꼬리를 갖는,
방법. - 제4항 또는 제5항에 있어서,
인공 NA 분자의 참조 세트를 제공함을 또한 포함하며, 여기에서 상기 참조 세트의 NA 분자 중 적어도 2개, 바람직하게는 각각이, 바람직하게는 동일한 용기 중에 소정의 몰량으로 존재하고;
바람직하게는 상기 NA 분자의 적어도 2개의 각각의 몰량이 적어도 102, 바람직하게는 적어도 103, 보다 바람직하게는 적어도 105, 특히 적어도 106배만큼 상이하며, 특히 상기 NA 분자 중 적어도 2개가 액체 중에 용해된 상태로 제공되거나 또는 액체 중에 용해되거나 희석될 준비가 되어 있으며, 여기에서 그들 각각의 농도 또는 최종 농도 범위가 0.01 아토몰/㎕ 내지 100 펨토몰/㎕, 또는 100 젭토몰/㎕ 내지 1 펨토몰/㎕인,
방법. - 제4항 내지 제6항 중 어느 한 항에 있어서,
인공 NA 분자의 참조 세트의 서열이, NCBI GenBank 데이터베이스 수납 번호가 표 3에 나열된, 바람직하게는 표 3 및 표 4 중 어느 하나에 나열된 서열, 특히 바람직하게는 2014년 6월 15일자 발매 NCBI GenBank 데이터베이스 202의 모든 서열과 유사성을 갖지 않으며, 이때 통계학적 유의수준 한계(예상 한계)가 10-1 미만, 바람직하게는 1 미만, 특히 10 미만이고,
상기 유사성을 낮은 복잡성 영역의 필터링, 1차 갭 비용 및 1, -2의 매치/미스매치 점수와 함께 28의 워드 크기의 매개변수들을 갖는 BLASTn 프로그램에 의해 측정하는,
방법. - 제4항 내지 제7항 중 어느 한 항의 방법에 의해 획득될 수 있는, 전사물 변이체를 모방하는 인공 NA 분자의 참조 세트.
- 전사물 변이체, 바람직하게는 RNA 분자 또는 DNA 분자, 특히 RNA 분자를 모방하는 인공 NA 분자의 참조 세트로서,
A) 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 특히 적어도 5개의 NA 분자 그룹을 포함하고, 이때 각각의 그룹이 적어도 2개, 바람직하게는 적어도 3개, 보다 바람직하게는 적어도 4개, 특히 적어도 5개의 상이한 NA 분자로 이루어지며,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 모든 NA 분자가 동일한 인공 유전자의 참조 전사물 변이체이고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 NA 분자가 적어도 80 nt 길이의 서열을 공유하고, 상기 각 그룹의 적어도 2개의 NA 분자가 적어도 80 nt 길이의 적어도 또 다른 서열만큼 상이하며,
B) 상기 참조 세트는:
- 하기의 그룹 중에서 선택된 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 훨씬 더 바람직하게는 적어도 5개, 특히 모든 선택적인 전사 사건들을 모방하고/하거나:
선택적인 전사물 개시 부위(TSS), 선택적인 전사물 종료 부위(TES), 안티센스 전사물, 중복 전사물, 및 스키핑된 카세트 엑손(CE), 인트론 유지(IR), 상호 배타적인 엑손(MXE), 선택적인 3' 스플라이싱 부위(A3SS), 선택적인 5' 스플라이싱 부위(A5SS), 선택적인 첫 번째 엑손(AFE), 선택적인 최종 엑손(ALE) 및 트랜스-스플라이싱의 그룹 중에서 선택된 선택적인 스플라이싱 사건들;
- 500 nt 내지 2000 nt, 바람직하게는 750 nt 내지 1500 nt, 특히 1000 nt 내지 1400 nt의 평균 서열 길이를 가지며; 바람직하게는 300 nt 내지 1200 nt, 바람직하게는 600 nt 내지 900 nt, 특히 700 nt 내지 800 nt의 표준 편차; 적어도 100 nt의 최소 크기; 및 바람직하게는 10000 nt의 최대 크기를 갖고/갖거나;
- 25% 내지 55%의 평균 GC 함량을 갖고/갖거나;
- GAA, GAC, GAG, GAT, GCA, GCC, GCG, GCT, GGA, GGC, GGG, GGT, GTA, GTC, GTG, GTT 중에서 선택된 5' 개시 트리뉴클레오티드 또는 AA, AC, AG, AT, CA, CC, CG, CT, GA, GC, GG, GT, TA, TC, TG, TT 중에서 선택된 5' 개시 디뉴클레오티드 및/또는 AC, AG, AT, CC, CG, CT, GC, GG, GT, TC, TG, TT 중에서 선택된 3' 종료 디뉴클레오티드의 필수적으로 랜덤하게 분포된 존재를 갖고/갖거나;
상기 참조 세트의 각각의 인공 NA 분자가 5' 개시 뉴클레오티드로서 구아노신을 갖고/갖거나;
상기 인공 NA 분자의 참조 세트의 모든 엑손 서열내 모든 인트론 개시 디뉴클레오티드의 적어도 50%, 바람직하게는 적어도 75%, 특히 적어도 95%가 GT이며, 여기에서 상기 인트론 개시 디뉴클레오티드가 각각 상기 참조 세트의 또 다른 인공 NA 분자 중에 존재하지 않는 서열의 5' 말단 디뉴클레오티드이고 이에 의해 상기 또 다른 인공 NA 분자에 대한 인트론을 나타내고/내거나; 상기 인공 NA 분자의 참조 세트의 모든 엑손 서열내 모든 인트론 종료 디뉴클레오티드의 적어도 50%, 바람직하게는 적어도 75%, 특히 적어도 95%가 AT이며, 여기에서 상기 인트론 종료 디뉴클레오티드가 각각 상기 참조 세트의 또 다른 인공 NA 분자 중에 존재하지 않는 서열의 5' 말단 디뉴클레오티드이고 이에 의해 상기 또 다른 인공 NA 분자에 대한 인트론을 나타내고/내거나;
상기 참조 세트의 인공 NA 분자의 적어도 하나, 바람직하게는 각각이, RNA 분자인 경우, 5'-캡 구조를 갖고/갖거나, 적어도 10개, 바람직하게는 적어도 20개의 아데노신의 폴리-A 꼬리를 갖고;
C) 상기 참조 세트의 서열이, NCBI GenBank 데이터베이스 수납 번호가 표 3에 나열된, 바람직하게는 표 3 및 표 4 중 어느 하나에 나열된 서열, 특히 바람직하게는 2014년 6월 15일자 발매 NCBI GenBank 데이터베이스 202의 모든 서열과 유사성을 갖지 않으며, 이때 통계학적 유의수준 한계(예상 한계)가 10-1 미만, 바람직하게는 1 미만, 특히 10 미만이고,
상기 유사성을 낮은 복잡성 영역의 필터링, 1차 갭 비용 및 1, -2의 매치/미스매치 점수와 함께 28의 워드 크기의 매개변수들을 갖는 BLASTn 프로그램에 의해 측정하는,
참조 세트. - A) 서열번호 1 내지 148의 그룹 중에서 선택된 전체 서열과 적어도 80%, 바람직하게는 적어도 90%, 보다 바람직하게는 적어도 95%, 훨씬 더 바람직하게는 적어도 98%, 특히 100% 일치하는 서열; 또는
B) 서열번호 156 내지 334의 그룹 중에서 선택된 전체 서열과 적어도 80%, 바람직하게는 적어도 90%, 보다 바람직하게는 적어도 95%, 훨씬 더 바람직하게는 적어도 98%, 특히 100% 일치하는 서열을 갖는 적어도 하나의 엑손을 갖는 서열
을 포함하는, NA 분자, 바람직하게는 DNA 분자 또는 RNA 분자. - 서열번호 1 내지 148 중에서 선택된 서열의, 80 nt의 최소 크기를 갖는 서열 단편에 적어도 80%, 바람직하게는 적어도 90%, 보다 바람직하게는 적어도 95%, 훨씬 더 바람직하게는 적어도 98%인, 적어도 80개, 바람직하게는 적어도 150개의 연속적인 뉴클레오티드의 서열을 포함하는, NA 분자, 바람직하게는 DNA 분자 또는 RNA 분자.
- 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 특히 적어도 5개의 NA 분자 그룹을 포함하고, 이때 각각의 그룹이 적어도 2개, 바람직하게는 적어도 3개, 보다 바람직하게는 적어도 4개, 특히 적어도 5개의 상이한 제10항 또는 제11항의 NA 분자로 이루어지며,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 모든 NA 분자가 동일한 인공 유전자의 참조 전사물 변이체이고,
여기에서, 각 그룹에 대해 독립적으로, 상기 각 그룹의 NA 분자가 적어도 80 nt 길이의 서열을 공유하고, 상기 각 그룹의 적어도 2개의 NA 분자가 적어도 80 nt 길이의 적어도 또 다른 서열만큼 상이한,
전사물 변이체를 모방하는 인공 NA 분자의 참조 세트. - 제12항에 있어서,
상기 참조 세트가:
- 하기의 그룹 중에서 선택된 적어도 하나, 바람직하게는 적어도 2개, 보다 바람직하게는 적어도 3개, 훨씬 더 바람직하게는 적어도 5개, 특히 모든 선택적인 전사 사건들을 모방하고/하거나:
선택적인 전사물 개시 부위(TSS), 선택적인 전사물 종료 부위(TES), 안티센스 전사물, 중복 전사물, 및 스키핑된 카세트 엑손(CE), 인트론 유지(IR), 상호 배타적인 엑손(MXE), 선택적인 3' 스플라이싱 부위(A3SS), 선택적인 5' 스플라이싱 부위(A5SS), 선택적인 첫 번째 엑손(AFE), 선택적인 최종 엑손(ALE) 및 트랜스-스플라이싱의 그룹 중에서 선택된 선택적인 스플라이싱 사건들;
- 500 nt 내지 2000 nt, 바람직하게는 750 nt 내지 1500 nt, 특히 1000 nt 내지 1400 nt의 평균 서열 길이를 가지며; 바람직하게는 300 nt 내지 1200 nt, 바람직하게는 600 nt 내지 900 nt, 특히 700 nt 내지 800 nt의 표준 편차; 적어도 100 nt의 최소 크기; 및 바람직하게는 10000 nt의 최대 크기를 갖고/갖거나;
- 25% 내지 55%의 평균 GC 함량을 갖고/갖거나;
- GAA, GAC, GAG, GAT, GCA, GCC, GCG, GCT, GGA, GGC, GGG, GGT, GTA, GTC, GTG, GTT 중에서 선택된 5' 개시 트리뉴클레오티드 또는 AA, AC, AG, AT, CA, CC, CG, CT, GA, GC, GG, GT, TA, TC, TG, TT 중에서 선택된 5' 개시 디뉴클레오티드 및/또는 AC, AG, AT, CC, CG, CT, GC, GG, GT, TC, TG, TT 중에서 선택된 3' 종료 디뉴클레오티드의 필수적으로 균일하게 분포된 존재를 갖고/갖거나;
상기 참조 세트의 각각의 인공 NA 분자가 5' 개시 뉴클레오티드로서 구아노신을 갖고/갖거나;
상기 인공 NA 분자의 참조 세트의 모든 엑손 서열내 모든 인트론 개시 디뉴클레오티드의 적어도 50%, 바람직하게는 적어도 75%, 특히 적어도 95%가 GT이며, 여기에서 상기 인트론 개시 디뉴클레오티드가 각각 상기 참조 세트의 또 다른 인공 NA 분자 중에 존재하지 않는 서열의 5' 말단 디뉴클레오티드이고 이에 의해 상기 또 다른 인공 NA 분자에 대한 인트론을 나타내고/내거나; 상기 인공 NA 분자의 참조 세트의 모든 엑손 서열내 모든 인트론 종료 디뉴클레오티드의 적어도 50%, 바람직하게는 적어도 75%, 특히 적어도 95%가 AT이며, 여기에서 상기 인트론 종료 디뉴클레오티드가 각각 상기 참조 세트의 또 다른 인공 NA 분자 중에 존재하지 않는 서열의 5' 말단 디뉴클레오티드이고 이에 의해 상기 또 다른 인공 NA 분자에 대한 인트론을 나타내고/내거나;
상기 참조 세트의 인공 NA 분자의 적어도 하나, 바람직하게는 각각이, RNA 분자인 경우, 5'-캡 구조를 갖고/갖거나, 적어도 10개, 바람직하게는 적어도 20개의 아데노신의 폴리-A 꼬리를 갖고;
바람직하게는 상기 참조 세트의 서열이, NCBI GenBank 데이터베이스 수납 번호가 표 3에 나열된, 바람직하게는 표 3 및 표 4 중 어느 하나에 나열된 서열, 특히 바람직하게는 2014년 6월 15일자 발매 NCBI GenBank 데이터베이스 202의 모든 서열과 유사성을 갖지 않으며, 이때 통계학적 유의수준 한계(예상 한계)가 10-1 미만, 바람직하게는 1 미만, 특히 10 미만이고,
상기 유사성을 낮은 복잡성 영역의 필터링, 1차 갭 비용 및 1, -2의 매치/미스매치 점수와 함께 28의 워드 크기의 매개변수들을 갖는 BLASTn 프로그램에 의해 측정하는,
참조 세트. - 제9항, 제12항 및 제13항 중 어느 한 항에 있어서,
NA 분자 중 적어도 2개, 바람직하게는 각각이, 바람직하게는 동일한 용기 중에, 소정의 몰량으로 존재하고;
바람직하게는 상기 NA 분자의 적어도 2개의 각각의 몰량이 적어도 102, 바람직하게는 적어도 103, 보다 바람직하게는 적어도 105, 특히 적어도 106배만큼 상이하며, 특히 상기 NA 분자 중 적어도 2개가 액체 중에 용해된 상태로 제공되거나 또는 액체 중에 용해되거나 희석될 준비가 되어 있으며, 여기에서 그들 각각의 농도 또는 최종 농도 범위가 0.01 아토몰/㎕ 내지 100 펨토몰/㎕, 또는 100 젭토몰/㎕ 내지 1 펨토몰/㎕인,
세트. - 제1항 내지 제3항 중 어느 한 항에 있어서,
참조 세트가 제8항, 제9항, 제12항 및 제13항 중 어느 한 항, 바람직하게는 제12항 또는 제13항, 특히 제13항의 참조 세트이고, 상기 NA 분자 중 적어도 2개, 바람직하게는 각각이 소정의 몰량으로 존재하는, 방법. - 제1항 내지 제3항 중 어느 한 항에 있어서,
인공 NA 분자의 참조 세트를, 바람직하게는 안정화제와 함께 용기 중에 건조된 상태, 바람직하게는 동결-건조된 상태로 제공하는, 방법. - 제16항에 있어서,
하나 이상의 샘플 중의 전사물 변이체의 조절된 식별 및/또는 정량분석을 위한 방법을 수행하고, 단계 b)를, 상기 샘플을 용기에 가하고, 이에 의해 상기 샘플 중의 건조된 참조 세트를 용해시킴으로써 수행하는, 방법. - 제4항 내지 제7항 중 어느 한 항에 있어서,
물리적으로 획득된 참조 세트를 건조, 바람직하게는 동결-건조, 바람직하게는 안정화제와 함께 용기 중에서 건조시키는 단계를 또한 포함하는, 방법. - 제8항, 제9항 및 12항 내지 제14항 중 어느 한 항에 있어서,
인공 NA 분자의 참조 세트가, 바람직하게는 안정화제와 함께 용기 중에서 건조, 바람직하게는 동결-건조되어 제공되는, 참조 세트.
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- 2015-07-09 LT LTEPPCT/EP2015/065756T patent/LT3167076T/lt unknown
- 2015-07-09 CA CA2954495A patent/CA2954495C/en active Active
- 2015-07-09 US US15/323,951 patent/US10513726B2/en active Active
- 2015-07-09 DK DK15736490.2T patent/DK3167076T3/da active
- 2015-07-09 KR KR1020177002619A patent/KR102555447B1/ko active IP Right Grant
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| US20020110828A1 (en) * | 2001-01-12 | 2002-08-15 | Ferea Tracy L. | Methods and compositions for microarray control |
| US20070072189A1 (en) * | 2004-03-11 | 2007-03-29 | The Government Of The United States Of America As | Artificial mutation controls for diagnostic testing |
Non-Patent Citations (1)
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| Genome Res. 2011 Sep; 21(9): 1543-1551 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220000850A (ko) | 2020-06-26 | 2022-01-04 | 숙명여자대학교산학협력단 | 비타민 b1의 보호 및 전달을 위한 장용성 조성물 |
| KR20220000849A (ko) | 2020-06-26 | 2022-01-04 | 숙명여자대학교산학협력단 | 사이클로덱스트린을 이용한 경구투여용 복합 조성물 및 이의 제조방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| LT3167076T (lt) | 2022-02-10 |
| WO2016005524A1 (en) | 2016-01-14 |
| CA2954495C (en) | 2024-03-05 |
| AU2015286672B2 (en) | 2021-12-02 |
| DK3167076T3 (da) | 2022-02-21 |
| US10513726B2 (en) | 2019-12-24 |
| JP2017525341A (ja) | 2017-09-07 |
| JP2021153588A (ja) | 2021-10-07 |
| JP2020014478A (ja) | 2020-01-30 |
| JP7568581B2 (ja) | 2024-10-16 |
| CN106471134B (zh) | 2021-11-12 |
| CN106471134A (zh) | 2017-03-01 |
| JP6930910B2 (ja) | 2021-09-01 |
| CA2954495A1 (en) | 2016-01-14 |
| US20170321248A1 (en) | 2017-11-09 |
| KR102555447B1 (ko) | 2023-07-13 |
| HK1231518A1 (zh) | 2017-12-22 |
| EP3167076A1 (en) | 2017-05-17 |
| EP3167076B1 (en) | 2021-11-17 |
| AU2015286672A1 (en) | 2016-12-15 |
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