KR20160043241A - Agricultural products and the mycelium mixtures are fermented food composition for anticancer, antidiabetic, and immune function and method of preparing the same - Google Patents

Abstract

The present invention relates to a composition for fermentation of anticancer, antidiabetic and immunity, which is fermented by mixing agricultural products and cereal mycelia, and a process for producing the same. More particularly, the present invention relates to a fermented soybean composition comprising Moroheya, Aronia, After fermentation,
The fermentation-line-type composition can obtain anticancer and anti-diabetic effects from agricultural products and medicinal herbs having pharmacological effect, and fermentation-enhancing anticancer, antidiabetic and immunostimulatory fermental-line composition obtained by mixing agricultural products and cereal mycelia maximizing immunity enhancement And a process for producing the same.
The present invention relates to a method for producing a fermented soybean which comprises fermenting a fermented product by adding a mycelium of rice husk and a fermented mycelium of rice as a basic composition with Moroheya, Aronia and Sanaa as basic compositions, wherein 10 to 45% by weight of Moroheya, 15 to 25% 10 to 15% by weight of the mycelium of the present invention, 15 to 30% by weight of the mycelium of the brown rice condition, and 15 to 20% Including mushroom, cabbage, leek, liquorice, sugarcane, dermis, wheat, clove, liquor, lobule, jade bean, tosaja, gakyung, gardenia, licorice, hwanggi, And fermenting.
In addition, the present invention relates to a method for producing a liquid mycelium, comprising the steps of: (S10) cultivating a mushroom fungus as a liquid seed bacterium; (S20) inoculating the liquid seed bacterium into the grain; (c) cultivating, lyophilizing and pulverizing the inoculated grains; (S40) of adding the agricultural product and herbal medicines to the grain mycelia powder to obtain a powder by pulverizing the powder, and obtaining a fermented composition by fermenting, steaming and drying the powder obtained in the step (S40) (S50) and a step (S60) of heat-treating and extracting the fermented composition obtained in the step (S50).

Description

FIELD OF THE INVENTION [0001] The present invention relates to a composition for fermenting an anticancer, an anti-diabetic, an immunity enhancer, and a method for preparing the same, which is produced by mixing agricultural products and cereal mycelia,

The present invention relates to a composition for fermentation of anticancer, antidiabetic and immunity, which is fermented by mixing agricultural products and cereal mycelia, and a process for producing the same. More particularly, the present invention relates to a fermented soybean composition comprising Moroheya, Aronia, And fermenting the fermentation-line-type composition after fermentation.

In addition, the fermentation-line composition of the present invention can obtain anticancer and anti-diabetic effects from agricultural products and herbal medicines having pharmacological action, and furthermore, anticancer drugs, antidiabetic drugs, immune enhancement by fermenting agricultural products and cereal mycelia mixed with each other, And a method for producing the same.

At present, Korea is growing along with economic growth, the proportion of elderly people aged 65 or older is rapidly increasing, and adult diseases such as cancer, diabetes, obesity and hypertensive diseases are increasing together. In particular, according to the National Statistical Office 's 2005 death cause statistics, cancer accounts for 27% of all deaths, followed by cerebrovascular disease (12.3%) and heart disease (3.2%). Among them, 50s and 60s accounted for 67.4% of cancer deaths, and ischemic heart disease such as myocardial infarction and diabetes mellitus subordinate.

The reason for this increase in the number of adult diseases is that consumption of meat and instant processed foods is increasing as the income level of modern people increases.

These instant processed foods contain vitamins and minerals, which are fiber and metabolic nutrients, which are controlled by sugarcane and refined sugar, and they contain synthetic preservatives for preservation purposes, coloring agents to maintain color and aroma, Spices, and chemical seasoning for flavorings, etc., which are harmful to the human body, are introduced into various passages, which interfere with the metabolism of our body and act as carcinogenic substances. In addition, some of the salts such as sodium glutamate and sodium nitrite Sodium is excessively added to cause a mineral imbalance in the human body, resulting in serious end-of-life due to side effects of various adult diseases.

As a countermeasure, it is recommended to reduce the intake of instant processed foods and meat, and increase the intake of fruits, vegetables and grains. In particular, germinated foods and fermented foods are known to be abundant in various active nutrients that help physiologically active substances and digestive enzymes.

For example, Korean Patent Laid-Open Publication No. 10-2010-0004711 discloses a germinated food, which relates to a method for producing a functional germinated cereal, wherein the conventional method comprises immersing an arbitrary grain in an immersion liquid The method comprising the steps of: circulating the immersion liquid at predetermined time intervals; germinating the grains by adding a functional aqueous solution or an extract to the grape seedlings; And packaging.

The germinated grains are effective in constipation due to abundance of dietary fiber, amino acid and vitamin B group. However, the germinated grains have a disadvantage in that they do not chew smoothly due to their hard shells, resulting in poor foodability and digestibility and difficulty in ingestion.

Korean Patent No. 10-1338929 discloses a fermented food which can easily ingest germinated cereals. This prior art relates to a food supplement including a fermentation enzyme for cereals, The present invention relates to a nutritional supplement containing cereal fermentation enzymes for health promotion and maintenance, which comprises a fermentation enzyme obtained after fermentation for a certain period of time using a microorganism strain as a main ingredient.

The food aid of the prior art improves the digestion ability of the grain by fermenting the microorganism as a microorganism. However, the food aid is obtained by changing the characteristics of food using microorganisms, and the condition for fermentation is difficult and time This takes a long time.

In addition, the above-mentioned prior art is concerned only with nutritional supplementation, and thus there is a problem in that cancer patients and diabetic patients do not have the necessary anticancer and anti-diabetic efficacy.

Therefore, it is possible to easily ingest the nutritional components of germinated and fermented foods, which are widely recommended as health foods, and to provide anti-cancer and anti-diabetic effects to patients with chronic diseases (adult diseases, cancer) The development of food is urgent.

SUMMARY OF THE INVENTION The present invention has been conceived to solve the above-mentioned problems, and an object of the present invention is to provide a fermentation-line-type composition comprising Morozuya, Aronia,

In addition, the fermentation-line-type composition of the present invention is capable of obtaining anticancer and anti-diabetic effects from agricultural products and medicinal herbs having pharmacological action, and is also intended to maximize immunity enhancement.

It is another object of the present invention to provide a method for producing anticancer, anti-diabetic, and immunostimulatory fermental-line composition, which is obtained by mixing agricultural products and cereal mycelia.

The present invention relates to a method for producing a fermented soybean which comprises fermenting wheat flour mycelium and rice fermented mycelium, which are mycelium of cereals,

Wherein the composition comprises 8 to 86.5% by weight of Moroheya, 5 to 30% by weight of Aronia, 0.5 to 16% by weight of Rhodochrosa, 6 to 23% by weight of rice mycelia and 2 to 23% by weight of Rhizoma mycelia.

In addition, the present invention is characterized in that the grain mycelium further contains a mycelium-grown mycelium and a meso-state mycelium to be fermented.

The present invention also relates to the above-mentioned composition, wherein the basic composition is selected from the group consisting of jujube, kelp, bellflower, mushroom, shiitake, cabbage, leek, liquorice, ginseng, dermis, wheat, clove, Licorice, Hwanggi, Angelica gigas, Hansuo, genus, ginseng, and Korean ginseng.

In addition, the present invention relates to a method for producing a liquid mycelium, comprising the steps of: (S10) cultivating a mushroom fungus as a liquid seed bacterium; (S20) inoculating the liquid seed bacterium into the grain; (c) cultivating, lyophilizing and pulverizing the inoculated grains; (S40) of adding the agricultural product and herbal medicines to the grain mycelia powder to obtain a powder by pulverizing the powder, and obtaining a fermented composition by fermenting, steaming and drying the powder obtained in the step (S40) (S50) and a step (S60) of heat-treating and extracting the fermented composition obtained in the step (S50).

As described above, the anticancer, antidiabetic and immunomodulatory fermental-line composition of the present invention, which is fermented by mixing agricultural products and cereal mycelia, and a method for producing the same, are characterized in that Moroheya, Aronia, There is an effect of providing a fermented fermentation-line composition that has been fermented.

In addition, the fermentation-line-type composition of the present invention can obtain anticancer and anti-diabetic effects from agricultural products and medicinal herbs having pharmacological action, and also has an effect of maximizing immunity enhancement.

In addition, the present invention provides a method for producing antifungal, antidiabetic, and immuno-enhancing fermentation-line-containing compositions obtained by mixing agricultural products and cereal mycelia.

FIG. 1 is a flow chart showing a method of producing a fermentation-line composition for anti-cancer, anti-diabetic, and immunomodulatory fermentation by mixing agricultural products and cereal mycelia according to an embodiment of the present invention.

The fermentation-line composition for anticancer, antidiabetic and immunity enhancement fermented by mixing the agricultural products and the mycelium of cereals according to the present invention will be described as follows.

In one embodiment of the present invention, the mycelium of rice husk and the condition of mycelium of Yulmu are added to Moroheya, Aronia,

Wherein the composition comprises 8 to 86.5% by weight of Moroheya, 5 to 30% by weight of Aronia, 0.5 to 16% by weight of Rhodochrosa, 6 to 23% by weight of rice mycelia and 2 to 23% by weight of Rhizoma mycelia.

The Moroheya (scientific name: Corchorus olitorius L., jew's marrow, Egypt name: mulukhi-yya) is a plant belonging to the genus Pine and Jute. Moroheya is rich in carotene and various vitamins, potassium and calcium as compared to other green and yellow vegetables, and dietary fiber is contained at a maximum of 1.7 times as much as other green and yellow vegetables.

Therefore, it is known that when taking Moroheya, osteoporosis prevention effect, anticancer and anti-diabetic effect can be obtained by these useful ingredients, and it is also excellent for constipation and skin beauty.

In the composition of the present invention, Moroheya does not exhibit anti-cancer or anti-diabetic effect when it is less than 8% by weight based on the total weight of the composition of the present invention, and when the dietary fiber contained in Moroheya exceeds 86.5% by weight, And the absorption of inorganic substances in the body is suppressed.

The Aronia is a deciduous shrub native to northern America, a plant belonging to the genus Rosaceae. The above-mentioned Aronia contains vitamin C, anthocyanin, polyphenol, carotenoid, calcium, magnesium, copper, zinc, manganese and the like. Especially, the anthocyanin contained in Aronia contains 4 times more than blueberry and 80 times more than grape.

The anthocyanin contained in the Aronia has an antioxidative effect by removing active oxygen in the body, inhibits the growth of cancer cells, and activates insulin, thereby helping to manage blood sugar in diabetic patients.

In case of less than 5% by weight of the total weight of the composition according to the present invention, the active oxygen-removing ability is poor and the antioxidative effect is not exhibited. If it exceeds 30% by weight, the activity of digestive juice is increased and gastric acidity is increased. Or duodenal ulcer patients.

Saengsa is a medicinal herb that is used as a herbal medicine for digestive herb that belongs to Rosaceae. Quercetin, quercetin, rutin, flavonoid, and amigalline are effective in reducing cholesterol in the blood and reducing blood pressure by inhibiting cholesterol deposition in the organs.

In the composition of the present invention, the amount of cholesterol in the blood is not lowered when the amount is less than 0.5% by weight based on the total weight of the composition of the present invention. When the amount of cholesterol is more than 16% by weight, toxic components of amygdalin contained in the sea horse are produced.

The above mycelium of mycelium and the mycelium of mycelium are cereal mycelium obtained by inoculating and culturing the mushroom bacteria in brown rice and yulmu. In order to compensate for the disadvantage that the brown rice and the yulmu peel are hard and do not chew smoothly and the ingestion is not easy because of the lack of texture and digestibility, cereal mushroom is inoculated into cereals and cultured to obtain cereal mycelium.

The brown rice contains many physiologically active ingredients such as vitamins B1, B2, E, saccharides, proteins, fats, minerals, linoleic acid, gamma-orzanol and inositol

In addition to starch, the yulmu protein, fat, vitamin B1. Vitamin B2. It contains a lot of iron and it acts to help metabolism. In one room, the tongue. Diuretic and prescription, hypertension inhibition, diuretic, weight control effect, neuralgia and edema is said to be effective.

Mushrooms are widely known as anticancer drugs. The pharmacological actions of the mushroom include the gastrointestinal cancer of the digestive system, esophagus cancer, duodenal cancer, colorectal cancer, rectal cancer, and chemotherapy after liver cancer surgery, the immune function is enhanced and the uterine hemorrhage and dyspepsia, menstrual irregularity, Is known to activate and detoxify.

Currently, there are two types of mushrooms certified as health supplements by the KFDA: Bauschia mushroom and Lentheus mushroom. Among them, Linheus condition is about 3 times higher in nutritional and other pharmacological components than Bausch .

The above-mentioned mushroom fungus can be used in both the bismuth mushroom and the Linseus mushroom, but it is more preferable to use the Linseus mushroom fungus. Linuteus mushroom has superior amino acid and inorganic contents compared to BauMi, and nutrients that help anticancer effect among nutrients of mushroom. Beta-glucan is about 4 times as much as Linmius mushroom .

In the present invention, when the mycelium of the present invention is less than 6% by weight based on the total weight of the composition of the present invention, and when the amount of the β-glucan is less than 2% by weight based on the total weight of the composition of the present invention, When the mycelium of the brown rice and the rice mycelium of the present invention are more than 23% by weight based on the total weight of the composition of the present invention, there is a problem of causing liver damage in the body, which is problematic for long-term use.

In addition, another embodiment of the present invention is characterized in that the cereal mycelium further comprises a fermented mycelia and a meso-situation mycelium, and fermented.

The mycelium of rice husk, mycelium of mycelium, and mycelium of mycelium, which are the mycelium of grain, are added to Moroheya, Aronia,

Wherein the grain mycelium further contains a mycelium-grown mycelium and a meso-state mycelium,

Wherein said mycelium is from 8 to 82.5% by weight, Aronia is from 5 to 18% by weight, fromage is from 0.5 to 13% by weight, from 6 to 17% by weight of brown rice mycelium, from 2 to 17% And 2 to 13.5% by weight of meso-state mycelium.

The mycelium and myzo condition mycelium were obtained by inoculating and cultivating the mushroom fungus on sorghum and mezzo. As in brown rice and yulmu, it is hard to chew mushrooms and mezzo shells, so it does not chew smoothly. To compensate for the shortage of food and digestibility, it is not easy to ingest. In order to compensate for the disadvantages, mushroom fungi are inoculated into cereals and cultured to obtain cereal mycelia.

Sorghum bicolor Moench contains a large amount of vitamins B1, B2, phosphorus, iron, calcium and the like, and has an effect of constipation and constipation.

The mezzo is a type of moxa that warms the body, detoxifies it, and is effective in gastrointestinal diseases and diabetes.

The mushroom fungus that is inoculated with sorghum and mesquat can be used in both Bausch & Linseus mushrooms, but it is preferable in terms of effectiveness to use Linheus mushroom fungus.

When the amount of beta-glucan is less than 2% by weight based on the total weight of the compositions of the present invention, the anticancer effect can not be obtained. When the amount of beta-glucan is more than 13.5% by weight, vomiting, dizziness, headache There is a problem that the symptoms of the disease appear.

In another embodiment of the present invention, the above-mentioned basic composition further comprises at least one selected from the group consisting of jujube, kelp, bellflower, oyster mushroom, shiitake mushroom, cabbage, leek, , Gyungyang, jiza, licorice, hwanggi, angelica, chrysanthemum, genus, ginseng, and gilt.

The mycelium of rice husk, mycelium of mycelium, and mycelium of mycelium, which are the mycelium of grain, are added to Moroheya, Aronia,

Wherein the grain mycelium further contains a mycelium-grown mycelium and a meso-state mycelium,

In the basic composition, there are added jujube, kelp, bellflower, oyster mushroom, shiitake, cabbage, leek, liquorice, sugarcane, dermis, wheat, clove, liquorice, , Baeksoo Oh, deity, Sammyung, and Ulgum,

The mycelia of the present invention can be obtained by mixing 8 to 70% by weight of Moroheya, 5 to 11% by weight of Aronia, 0.5 to 2% by weight of Rhodochrosite, 6 to 11% 0.5 to 2% by weight of seaweed, 0.5 to 2% by weight of sea tangle, 0.5 to 2% by weight of seaweed, 0.5 to 2% by weight of plumeria, 0.5 to 2% by weight of oyster mushroom, 0.5 to 2% 0.5 to 2% by weight of wheat, 0.5 to 2% by weight of wheat, 0.5 to 2% by weight of leek, 0.5 to 2% by weight of acid, 0.5 to 2% 0.5 to 2% by weight of jasmine, 0.5 to 2% by weight of jasmine, 0.5 to 2% by weight of jasmine, 0.5 to 2% by weight of soil, 0.5 to 2% 0.5 to 2% by weight, 0.5 to 2% by weight, 0.5 to 2% by weight, 0.5 to 2% by weight, By weight, and 0.5 to 2% by weight, respectively.

The jujube contains carbohydrates, proteins, organic acids, iron, calcium, and vitamin C. The jujube has the effect of increasing protein and albumin, helping to protect the liver, strengthen muscle strength and increase body weight.

When the jujube is less than 0.5% by weight based on the total weight of the composition of the present invention, there is a problem that the content of jujube is low due to the low content of jujube, and when it exceeds 2% by weight, There is a problem.

The sea grass belonging to the seaweed family of the kelp arborvitae contains proteins, fats, saccharides, fibers, ash, calcium, phosphorus, iron and iodine, and the saccharides include alginic acid, fucoidan and laminin.

The kelp acts to lower cholesterol levels and blood pressure. By adsorbing carcinogens, it can inhibit the absorption of carcinogens in the small intestine, thus reducing the risk of colon cancer and rectal cancer.

In case of less than 0.5% by weight of the composition of the present invention, the kelp of the present invention has a problem that the carcinogenic substance adsorption ability is poor and the anti-cancer effect is lowered. When the kelp is more than 2% by weight, There is a problem that often causes diarrhea.

The bellflower grows in the sunny areas of the mountainous plain, which is about 1,000 m above sea level. The height of the stem is 40 ~ 100 cm. Roots can be eaten and grow thick and short.

The roots of the bellflower contain saponin, one of the major components of ginseng, and are used as medicines. Bellflower lipids have a viscosity and distinctive aroma, and saturated fatty acids are more characteristic than unsaturated fatty acids.

Bellflower is a representative alkaline food rich in fiber, rich in calcium and iron, and a good source of vitamins and minerals. In one room, it is used for germ, bronchitis, asthma, drainage, inflammation, blood and blood.

If less than 0.5% by weight based on the total weight of the composition of the present invention is used, the platycodon of the present invention has a low content of fibrous components and is inferior in digestion efficiency. When the content is more than 2% by weight, the platycodon has a strong flavor and bitter taste.

The oyster mushroom is an edible mushroom of the oyster, and it grows in the dry dead wood of the broad-leaved tree or the stump of the dead wood from spring to autumn. Oyster mushrooms contain proteins, carbohydrates, lipids, iron, potassium, calcium, phosphorus, niacin, vitamin C, dietary fiber, zinc, folic acid and ash.

Oyster mushroom contains beta-glucan-D and MD-fraction which has strong immunity activating action. The MD-fraction prevents cancer cells from growing further, prevents metastasis, and thus has a good anti-cancer effect.

In the composition of the present invention, the oyster mushroom of the present invention has a problem that the anticancer effect is lowered due to the immunity activating action when it is less than 0.5% by weight with respect to the total weight of the composition of the other examples. When the oyster mushroom is more than 2% by weight, A problem such as diarrhea arises in a weak person.

The shiitake mushroom grows in the trees of hardwood such as chestnut, oak, and oak tree. When the mushroom is dried in the sun, the esophagus, the precursor of vitamin D, is activated.

Shiitake mushroom cleanses the mind and strengthens the digestive system. It promotes food digestion, and stops vomiting and diarrhea. Lentinan in shiitake mushrooms enhances cellular immunity and humoral immunity, and inhibits cancer cells.

In the composition of the present invention, the shiitake mushroom of the present invention is less than 0.5% by weight based on the total weight of the composition, and the immunity enhancing effect can not be obtained due to deterioration of cellular immunity and humoral immunity. If the shiitake mushroom is more than 2% by weight, There is a problem that a slight skin disease occurs to a person.

The cabbage is a biennial herbaceous plant belonging to the cruciferous family. It contains pepsin, trypsin, and peroxidase enzyme. It contains antioxidant beta-carotene and vitamin C, chlorophyll to prevent damage to genes, dietary fiber to prevent colon cancer, , indole-3-acetal dehyde, glucobrassincin, flavonol (phenol), leucosanthosyanin, chlorogenic acid, and allyl isothiocyanate containing sulfur. It also activates leukocytes and acts to stimulate the secretion of tumor necrosis factor, which prevents cancer growth.

The cabbage according to the present invention can inhibit leukocyte activation when the amount of the cabbage is less than 0.5% by weight based on the total weight of the composition of the other examples, and can not inhibit tumor growth because the tumor necrosis factor is not secreted. There is a problem with the digestive function being obstructed.

The leek is a perennial herb that belongs to the lily family. Unlike other vegetables, when seeds are sprayed once, seeds are sprouted from the roots in the following year and continue to grow. It grows three to four times from spring to autumn. In summer, a blue stalk emerges between the leaves, and a small white flower blooms on the end. The fruit is ripe and spontaneously bursts. In addition, the leek is glandular secretion is strong, promote digestion and strengthen the stomach. And the seeds of leek are called "苟子" in one room, so they are used for medicinal purposes to maintain the body temperature. It is also used as a hemostatic agent because it is effective when you take a fresh juice and breathe it with red pepper in a blood or a hematemesis (hematemesis).

Leek contains sulfur compounds, which acts as an antioxidant that prevents damage to cells by reactive oxygen species and activates them to remove toxins from carcinogens. Because of these characteristics, leek acts on stomach cancer, colon cancer, skin cancer, lung cancer, liver cancer, etc., and prevents the cell from being transferred to cancer and prevents cancer cell growth.

In case of less than 0.5 wt% of the total weight of the composition of the present invention, the effect of removing toxins from active oxygen and carcinogens is low and the anti-cancer effect is lowered. In case of more than 2 wt% There is a problem.

It is a perennial vine plant belonging to the perennial plant. It is an alkaline plant rich in various inorganic components, containing protein and mannan as saccharides. It also contains amylase and has good digestibility.

It is used for the weakness of the body, pulmonary tuberculosis, dehydration of the water, oil well, enuresis, diabetes, etc., because it has the efficacy such as nourishment, ginseng, bobbi,

If the amount of amylase is less than 0.5% by weight based on the total weight of the composition of the other embodiment of the present invention, the digestive function is poor and the digestive power is not reinforced to humans. If the amount is more than 2% by weight, there is a problem.

The above-mentioned sugar is a medicinal product made from roots of Codonopsis pilosula Nannfeldt, and is effective for the body fatigue, poor digestion and absorption, cough, thirst, Anti-fatigue and immunity hyperactivity, erythrocyte hyperactivity, peptic ulcer, hypotension, and cardiovascular, brain, lower limb and visceral blood flow.

The saccharide composition of the present invention can not lower the blood pressure of a person having a high blood pressure when it is less than 0.5% by weight based on the total weight of the composition of the other examples. If it is more than 2% by weight, .

The dermis is a perilla of mature fruit of citrus unshiu (Citrus reticulata in China), an evergreen tree belonging to the genus Rutaceae. The efficacy of the dermis is to communicate the aura of the lungs to improve the digestive organs, and to remove the moisture, relieving symptoms such as chest tightness and coughing.

If the dermis of the present invention is less than 0.5% by weight based on the total weight of the composition of the other examples, the calcium absorption capacity of the body is lowered. If the dermis exceeds 2% by weight, dyspepsia and constipation may be caused.

The wheat is an annual plant of the monocotyledonous plant lemon tree, and has the effect of lowering heat and stopping the thirst, and relaxing the mind. It is used to treat anxiety, chest tightness, thirst, diarrhea, skin boils, trauma bleeding.

The wheat of the present invention may not have the effect of wheat when the content of the wheat is less than 0.5% by weight based on the total weight of the composition of the other examples, and the content of wheat gluten is increased when the content of the wheat exceeds 2% by weight to cause atopy or allergy .

The clove refers to a bud of Syzygium aromaticum Merrill et Perry which is caused by cold of the stomach, gastric cancer, abdominal pain, digestive problems, increased sexual function, gingival inflammation and gum ache, Secretion, analgesic, anti-convulsive, anti-inflammatory, antioxidant, antithrombotic, antimicrobial, antiparasitic, hypotensive action.

In case of less than 0.5% by weight of the composition of the present invention, the clove of the present invention can not activate the secretion of gastric juice and it does not help to improve digestion. If it is more than 2% by weight, There is a problem.

It is known that Morus alba L., which is a deciduous tree belonging to Moraceae, is harvested when it shows magenta and dried and used as a medicinal herb. It is known to be used for treating dizziness, tinnitus, thirst, In Japan, it regulates the efficacy and fever of bloody bloom and is applied to treatments such as tonic, analgesic, insomnia, tinnitus, dizziness, back pain, and constipation.

In addition, the elderly have an antidiabetic effect of controlling blood sugar.

In case of less than 0.5% by weight based on the total weight of the composition of the present invention, the antidiabetic effect of the present invention can not be obtained due to its poor ability to control blood sugar. If the amount is more than 2% by weight, there is a problem.

The self-lobed leaves are used to dry the leaves of the green tea leaves, and the leaves are finely chopped. There is a certain ratio of stem and leaf, and it is mixed with fruit and there is a strong smell of wormwood.

The lobular lobe stabilizes the weakened mind and body by nervous breakdown and relieves insomnia. And it has the function of lowering blood sugar and cholesterol in the body. It removes the toxins in the body by carotene in the lobular lobes.

When the total weight of the composition of the present invention is less than 0.5% by weight based on the total weight of the composition of the present invention, the blood sugar and cholesterol in the body can not be lowered and the antidiabetic effect can not be obtained. This dry problem arises.

The oxjisu (corn salad) is rich in vitamin A and contains tocopherol, a natural antioxidant that prevents oxidation of cells. And it makes urine come out well, and it gives heat to the face. In addition, it has an anti-inflammatory action and a blood pressure lowering action, and is effective for chronic nephritis, acute chronic cystitis, urethritis, jaundice and hypertension.

In case of less than 0.5% by weight of the total weight of the composition of the present invention, the oximic acid of the present invention has a problem that the blood pressure lowering effect is weak and the blood pressure can not be lowered.

It is known as a medicinal herb that protects the liver and kidneys, brightens the eyes, helps the kidneys, and strengthens the kidney function. It strengthens the bones, strengthens the back strength, and weakens the kidneys and heals back and knees and sore. It is also known to be effective in the treatment of diabetes, as well as in the treatment of illness and diarrhea that can not see urine and urine.

In the composition of the present invention, the content of the soil is lower than 0.5% by weight based on the total weight of the composition of the present invention, and the function of protecting the liver and kidney is lowered. When the amount of the soil is more than 2% There is a problem that boils up.

The Gyeonggyeong is a medicine made by removing the roots or junks of Platycodon grandiflorum A. De Candolle. It treats the symptoms of the lungs and seawater and sputum, which is uncomfortable to breath, cleanses the lungs, Release the cold air of the stomach to stop the cough and remove the wall. Sore throat, cold cough, sputum, nasal congestion, asthma, bronchial inflammation, pleurisy, headache, chills and tonsillitis. There are pharmacological actions such as a gadome effect, a hypoglycemic action, and a cholesterol-lowering action.

In case of less than 0.5 wt% of the total weight of the composition of the present invention, the glycyrrhizin of the present invention has a lowering effect on blood glucose lowering effect and a cholesterol lowering effect and has no anti-diabetic effect. When it is more than 2 wt%, it has a strong incense and bitter taste, There is an inconvenience.

The gardenia is a mature fruit of gardenia (Gardenia jasminoides Ellis), an evergreen shrub belonging to the Rubiaceae. The effectiveness of the gardenia eliminates the anxiety and aggravation of the body, reduces the heat in the body, helps the diuretic effect, cools the blood in the body, and detoxifies. Gardenia is known to have an effect on sleep duration and blood pressure lowering.

In case of less than 0.5 wt.% Of the total weight of the composition of the present invention, the sprout of the present invention does not lower blood pressure to a person having a high blood pressure. If the sprout is more than 2 wt%, symptoms such as stomach dysfunction, There is a problem that appears.

This licorice is a perennial herb with roots of dicotyledonous roots and roots. It harmonizes the toxicity of all the drugs to make it appear more effective. It regulates the heat and scent of the book, makes good communication of all blood vessels, and strengthens the muscles and bones. Pharmacological action is effective in detoxification, hepatitis, urticaria, dermatitis, eczema. In addition, Jinhae, genomes, muscle relaxation, diuretic, anti-inflammatory and suppresses peptic ulcers.

In case of less than 0.5% by weight of the total weight of the composition of the present invention, the licorice extract of the present invention can not obtain anti-inflammatory effect due to its low content of licorice, while if it exceeds 2% by weight, it reduces the discharge of urine and sodium, There is a problem of raising sodium in the blood.

The herbarium is a perennial herbaceous plant belonging to the soybean family. It has active ingredients of folic acid and choline to inhibit the development of nephritis and to prevent proteinuria (protein in the urine) and cholesterol It also slows the onset of blood pressure and has a blood pressure lowering effect.

The efficacy of Hwanggi is easily fatigued, weak in strength, low in voice, weak in pulse and exhibiting remarkable efficacy in sweaty person, widely used in uterine drainage, gastrointestinal tract, esophagus, uterine hemorrhage, It also increases muscle tension.

Hwanggi reduces the toxicity of platinum-based anti-cancer drugs and corrects the deficiency of T-cells, which are mainly responsible for cellular immunity.

In case of less than 0.5% by weight based on the total weight of the composition of the present invention, the effect of reducing the toxicity of the anticancer drug is inferior. When the amount of the anticancer drug is more than 2% by weight, do.

Angelica gigas Nakai Root of Angelica gigas Nakai, the efficacy of Angelica gigas Nakai has a blood-producing (blood-clotting) action when blood is lacking, and a blood-clotting action It has strong anticancer effect and hypotensive effect. In addition, pharmacologically, Angelica promotes the blood flow of the coronary arteries and stimulates erythropoiesis.

In case of less than 0.5% by weight of the total weight of the composition of the present invention, the Angelica giga of the present invention causes anxiety due to lack of mental and physical stability, and when it is more than 2% by weight, diarrhea can not be stopped in a person having a weak intestine or stomach .

It is a perennial herbaceous perennial plant with a dicotyledonous perennial herbaceous plant. It strengthens the kidney function, improves the function of the liver, eliminates fatigue, fills the skin, and strengthens the bones and muscles. In addition, it strengthens the heart and is also effective in the case of nervous breakdown or insomnia.

In case of less than 0.5% by weight based on the total weight of the composition of the present invention, improvement in kidney, liver and heart function can not be observed due to low water content, and when the amount is more than 2% by weight, There is a lot of problems, and a cold sweat problem occurs.

This herb is a medicinal herb made of roots of Dipsacus asperoides CY Cheng et TM Ai (川 西 斷) with a rabbit blossom. It shows liver and ginseng. It strengthens the muscles and communicates blood vessels, , Pain caused by joint fatigue.

The speed of the present invention is less than 0.5% by weight based on the total weight of the composition of the present invention, and is not used for early dysentery or vase patients due to the warm nature of the fasting portion when the amount is more than 2% by weight.

It is a perennial vine plant that grows in the forests of various places in Korea. There are many phosphorus, thiamin, riboflavin, protein, lipid, saccharides, vitamins B1 and B2, and saponin and sterol in white juice of ginseng. In addition, pneumococcal, streptococcus, and influenza bacteria have an inhibitory action, increases red blood cells, hemoglobin, and reduces the effect of leukocyte.

Recently, the effect of suppressing lung cancer and ovarian cancer has been proven in bovine spongiform encephalopathy, and it has been proved that respiratory function is improved by activating lung function to weak taiko.

In case of less than 0.5% by weight of the total weight of the composition of the present invention, the bacterium inhibiting action is lowered and the generation of red blood cells or hemoglobin is delayed to slow the recovery of fatigue after the chemotherapy, There is a problem that a temporary digestive disorder occurs.

The Ulgum is a medicinal substance of several species belonging to the genus Curcuma. It mediates the circulation and helps the circulation of blood. It treats menstrual cramps, menstrual irregularities, flank pain, heals the blood, cleanses the mind, Promotes bile secretion and treats gallstones. Pharmacological action reduces bile secretion, excretion promotion, and nodule formation in coronary arteries.

In addition, curcumin in curcumin has a strong antioxidant activity and induces the death of cancer cells, thereby preventing cancer of digestive organs. The curcumin interferes with certain actions that help cancer cell growth, thereby blocking major protein expression associated with esophageal cancer, thereby lowering the incidence of cancer in the esophagus.

If the content of curcumin is lower than 0.5% by weight based on the total weight of the composition of the present invention, the content of curcumin contained in the curd is lowered and the cancer cell growth can not be inhibited. . ≪ / RTI >

The method for preparing antifungal, antidiabetic and immunomodulatory fermenting-line compositions according to the present invention is described below with reference to the accompanying drawings.

FIG. 1 is a flow chart showing a method of producing a fermentation-line composition for anticancer, antidiabetic and immune enhancement fermented by mixing agricultural products and cereal mycelia according to an embodiment of the present invention.

Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings, but it should be understood that the present invention is not limited thereto.

The present invention relates to a method for cultivating a mycelium of mushrooms, comprising the steps of: (S10) cultivating a mushroom microorganism into a liquid seed culture; (S20) inoculating the liquid seed culture into a cereal grains; culturing, lyophilizing and pulverizing the inoculated grains to obtain a cereal- (S40) of adding powdered agricultural products and herbal medicines to the grain mycelial powder and pulverizing the powder to obtain a powder (S40); obtaining a fermented composition by fermenting, steaming and drying the powder obtained in the step S40 And a step (S60) of heat-treating and extracting the fermented composition obtained in the step (S50).

The manufacturing method of the present invention will be described separately for each step.

The step (S10) of culturing the condition mushroom bacteria as a liquid seed bacterium is carried out.

In order to prepare the liquid seed culture, a natural medium composed of germinated barley extract, glucose, and germanium mineral water having a pH of 6.5 was used. The mushroom fungus is added to the natural medium in an Erlenmeyer flask and cultured at 25 to 30 ° C for 5 to 10 days. When the cultivation is completed, the cultivated mushroom bacteria in a 30 L fermenter comprising aeration device, hydrogen ion concentration control device, and temperature control device are put into the flask, and the rotation speed of the agitating blade of the aeration agitating device is rotated at 300 to 500 rpm, Cultivate seeds.

When glucose is completely decomposed for about 3 days, residual sugar is not left, so that the nutrient necessary for the medium is provided and the purity of the cultured mycelium is maintained. The glucose may be anhydrous glucose or purified glucose.

The germanium mineral water is mineral water containing a large amount of germanium component through germanium ore, and it provides a toxic and beneficial component to the human body.

The germanium not only radiates a large amount of far-infrared rays which are beneficial to the human body, but also acts as an antimicrobial, antifungal, noxious gas-absorbing and decomposing agent and an anion releasing agent.

By using the germanium mineral water, it is possible to improve the growth performance of the cultured mycelia.

In addition, the germanium mineral water has a pH of 6.5, thereby achieving hydrogen ion concentration, which is an optimum condition for germanium growth without adding a separate buffer solution, thereby forming a non-toxic medium.

(S20) of inoculating the germinated cereals to the liquid seed bacterium.

The germinated grains are obtained by immersing grains in germanium mineral water having a pH of 6.5, germinating them and sterilizing them.

Preferably, the grain is germinated by selecting at least one of the group consisting of brown rice, yuwoo, sorghum and meso.

The grains to which the embryo is adhered are immersed in germanium mineral water for 24 hours, and the germanium mineral water used is water containing 0.2 to 0.8 ppm germanium per kg, which promotes germination and prevents spoilage and oxidation in the germination process .

Grafts with increased water content by impregnating germanium mineral water for 24 hours are sterilized and cooled with sterilized mineral water at 110-130 ° C at 1.2 atmospheres for 70-100 minutes. After cooling, it is allowed to stand at 20 to 25 ° C for 4 to 7 hours. When 1 to 2 hours have elapsed, germination is induced from the embryo of the grain.

When germination starts, it is rapidly cooled to prevent germination. This is because various nutrients can maintain the maximum value when germination of the embryo reaches about 0.2 to 0.5 mm.

The germinated embryo is maintained at a water content of 60 to 70%, and then the seeds of the liquid phase are inoculated. Liquid bacterium is a mycelium of mushroom cultured using a natural medium, which is homogenized and injected at high pressure into the prepared embryo at a pressure of 2 Kg. Then, it becomes possible to uniformly inoculate the upper and lower parts simultaneously.

The inoculated grains are cultured, lyophilized and pulverized to obtain a grain mycelium powder (S30).

The grains inoculated from the liquid seed culture are incubated in a culture container at a temperature of 25 to 30 DEG C for 30 to 35 days. The relative humidity is maintained at 60 to 75%, and automatic forced circulation is used to maintain the temperature and humidity.

The cultured germinated grains are placed in a hood mixer, pulverized for about 5 to 10 minutes, powdered, and lyophilized.

The above freeze-drying is rapid-cooling to -80 to -60 캜, followed by drying for 5 to 10 days while maintaining the temperature at 25 to 35 캜.

(S40) of adding agricultural products and herbal medicines to the grain mycelium powder and pulverizing the powder to obtain a powder.

The above-mentioned flour mycelial powder, agricultural products and herbal medicines are pulverized and pulverized with a particle size of 200 to 500 mesh to obtain a powder.

The mycelial powder, agricultural products and medicinal materials of the cereals were classified into a group consisting of Moroheya, Aronia, Sasa, mycelium of brown rice, mycelium of Yulmu mycelia, or myoheya, Aronia, And myzo conditional mycelia, or myosa, Aronia, Sasa, mycelium mycelium, and mycelium mycelium, mycelium mycelium, jujube, bellflower, mushroom, shiitake mushroom, cabbage, It is furthermore added to the grinder including the liquorice, ginseng, dermis, wheat, clove, liquor, lobster, jade bean, tosaja, gyeonggyeong, gardenia, licorice, hwanggi, ginseng,

The powder obtained in the step S40 is fermented, steamed and dried to obtain a fermented composition (S50).

The powder obtained in the step S40 is put into a fermenter and fermented for 5 to 7 days. In order to prevent pollution during fermentation, aerobic fermentation is carried out using a special fermentation tank, which is a special fermentation tank. The filtered air is injected using a HEPA filter (high-performance filter for removing fine particles from air) and a 0.45 μm filter, CO ₂ and CaS are removed. At this time, a 0.45 μm filter is also used in the gas outlet during fermentation to prevent contamination (fungus, bacillus, tactile, etc.) that may occur in the reverse flow air.

The composition obtained after the fermentation is put into a steamer and steamed at a temperature of 80 to 95 ° C for 8 to 10 hours and then dried in a drier at a temperature of 65 to 75 ° C for 8 to 10 hours to obtain a fermented composition.

The step (S60) of heat-treating and extracting the fermented composition obtained in the step (S50) is performed.

The fermentation composition obtained in the above step (S50) is finely pulverized by a pulverizer, and then filtered through a filter paper of 50 to 150 mesh. 1 L of water is added to 1 kg of the pulverized product obtained after the filtration, and the mixture is heated with stirring at 90 to 100 캜 for 2 to 5 hours to obtain an extract. The extract is centrifuged at 1,000 to 3,000 rpm for 5 to 15 minutes to precipitate the residue. After the precipitated residue is removed, the obtained extract is concentrated under reduced pressure at a temperature of 50 to 70 ° C under 700 mmHg and lyophilized to obtain a fermentation-line-type composition.

Hereinafter, examples, comparative examples and test examples of the present invention will be described in detail.

The following examples, comparative examples, and test examples are illustrative of the present invention, and the present invention is not limited to the following examples, comparative examples, and test examples.

Agricultural Products Division Grain mycelium  Mixed and fermented anticancer, Anti-diabetic , Fermentation for immunity enhancement Wire  Method of manufacturing composition Example  One

(S10): In order to prepare a liquid seed culture, a natural medium composed of germinated barley extract, glucose, and germanium mineral water having a pH of 6.5 was used. The natural mushroom was placed in an Erlenmeyer flask and cultured at 28 ° C for 7 days. After cultivation was completed, the mushroom cultured in a 30 L fermenter comprising aeration device, hydrogen ion concentration control device, and temperature controller was placed, and the rotation speed of the agitating blade of the aeration agitator was rotated at a rate of 400 revolutions per minute, Lt; / RTI >

(S20): Preferably, the germinated cereal is germinated by dipping it in germanium mineral water having a pH of 6.5, germinating it and sterilizing it, and selecting the germination by selecting at least one of the group consisting of brown rice, radish, sorghum and meso.

The grains attached to the embryo are immersed in germanium mineral water for 24 hours, and the germanium mineral water is water containing 0.5 ppm germanium per 1 Kg, which promotes germination and prevents spoilage and oxidation in the germination process.

Germinated water was impregnated in the mineral waters for 24 hours, and the moisture content of the grains was sterilized and cooled by sterilized mineral water at 121 ° C for 90 minutes at 1.2 atm. After cooling, the mixture is allowed to stand at 23 DEG C for 5 hours. When 1 to 2 hours have elapsed, germination is induced from the embryo of the grain.

The germinated embryos were maintained at a water content of 65%, and then inoculated with liquid seeds. Liquid bacterium was cultivated using natural medium, which was homogenized and sprayed at high pressure on the prepared embryo at a pressure of 2 Kg. Then, it becomes possible to uniformly inoculate the upper and lower parts simultaneously.

(S30): The grains inoculated from the liquid seed culture were cultured in a culture container at 28 DEG C for 30 days. At this time, the relative humidity is maintained at 65%, and automatic forced circulation is used to maintain the temperature and humidity.

The cultured germinated grains are placed in a hood mixer, pulverized for about 5 to 10 minutes, powdered, and lyophilized.

The above freeze-drying is rapid-cooling to -70 캜, followed by drying for 7 days while maintaining the temperature at 30 캜.

(S40): The above-mentioned flour mycelial powder, agricultural products and herbal medicines were pulverized and pulverized with a particle size of 300 mesh to obtain a powder.

The above-mentioned flour mycelial powder, agricultural products and herbal medicines were pulverized in a pulverizer in an amount of 25% by weight of Moroya, 25% by weight of Aronia, 10% by weight of Crassica japonica, 20% by weight of mycelium of brown rice and 20%

(S50): The powder obtained in the above step (S40) is put into a fermenter and fermented for 7 days. The composition obtained after the fermentation was put into a steamer and steamed at a temperature of 90 ° C for 9 hours and then dried in a drier at a temperature of 70 ° C for 9 hours to obtain a fermented composition.

(S60): The fermentation composition obtained in the above step (S50) is finely pulverized by a pulverizer, and then filtered through a 100-mesh screen. 1 L of water was added to 1 kg of the pulverized product obtained after the filtration, and the mixture was heated with stirring at 95 캜 for 4 hours to obtain an extract. The extract was centrifuged at 2,500 rpm for 10 minutes to precipitate the residue. After the precipitated residue was removed, the obtained extract was concentrated under reduced pressure at 60 ° C under 700 mmHg, and lyophilized to obtain a fermentation-line-type composition.

Agricultural Products Division Grain mycelium  Mixed and fermented anticancer, Anti-diabetic , Fermentation for immunity enhancement Wire  Method of manufacturing composition Example  2

(S10): In order to prepare a liquid seed culture, a natural medium composed of germinated barley extract, glucose, and germanium mineral water having a pH of 6.5 was used. The mushroom bacteria were added to the natural medium in an Erlenmeyer flask and cultured at 28 ° C for 7 days. After cultivation was completed, the mushroom cultured in a 30 L fermenter comprising aeration device, hydrogen ion concentration control device, and temperature controller was placed, and the rotation speed of the agitating blade of the aeration agitator was rotated at a rate of 400 revolutions per minute, Lt; / RTI >

(S20): Germinated grains were obtained by immersing grains in germanium mineral water having a pH of 6.5, germinated and sterilized. Preferably, the grain is germinated by selecting at least one of the group consisting of brown rice, yuwoo, sorghum and meso.

The grains attached to the embryo are immersed in germanium mineral water for 24 hours. The germanium mineral water uses 0.5 ppm germanium per kg, which promotes germination and prevents spoilage and oxidation during germination.

Germinated water was impregnated in the mineral waters for 24 hours, and the moisture content of the grains was sterilized and cooled by sterilized mineral water at 121 ° C for 90 minutes at 1.2 atm. After cooling, the mixture is allowed to stand at 23 DEG C for 5 hours. When 1 to 2 hours have elapsed, germination is induced from the embryo of the grain.

The germinated embryos were maintained at a water content of 65%, and then inoculated with liquid seeds. Liquid bacterium was cultivated using natural medium, which was homogenized and sprayed at high pressure on the prepared embryo at a pressure of 2 Kg. Then, it becomes possible to uniformly inoculate the upper and lower parts simultaneously.

(S30): The grains inoculated from the liquid seed culture were cultured in a culture container at 28 DEG C for 30 days. At this time, the relative humidity is maintained at 65%, and automatic forced circulation is used to maintain the temperature and humidity.

The cultured germinated grains are placed in a hood mixer, pulverized for about 5 to 10 minutes, powdered, and lyophilized.

The above freeze-drying is rapid-cooling to -70 캜, followed by drying for 7 days while maintaining the temperature at 30 캜.

(S40): The above-mentioned flour mycelial powder, agricultural products and herbal medicines were pulverized and pulverized with a particle size of 300 mesh to obtain a powder.

The mycelia powder, agricultural products, and medicinal materials of the cereals were 16% by weight of Moroya, 16% by weight of Aronia, 12% by weight of Crassus syrup, 16% by weight of rice mycelia, 16% by weight of Mycelium mycelium, 12% By weight and 12% by weight in the pulverizer.

(S50): The powder obtained in the above step (S40) is put into a fermenter and fermented for 7 days. The composition obtained after the fermentation was put into a steamer and steamed at a temperature of 90 ° C for 9 hours and then dried in a drier at a temperature of 70 ° C for 9 hours to obtain a fermented composition.

(S60): The fermentation composition obtained in the above step (S50) is finely pulverized by a pulverizer, and then filtered through a 100-mesh screen. 1 L of water was added to 1 kg of the pulverized product obtained after the filtration, and the mixture was heated with stirring at 95 캜 for 4 hours to obtain an extract. The extract was centrifuged at 2,500 rpm for 10 minutes to precipitate the residue. After the precipitated residue was removed, the obtained extract was concentrated under reduced pressure at 60 ° C under 700 mmHg, and lyophilized to obtain a fermentation-line-type composition.

Agricultural Products Division Grain mycelium  Mixed and fermented anticancer, Anti-diabetic , Fermentation for immunity enhancement Wire  Method of manufacturing composition Example  3

(S10): In order to prepare a liquid seed culture, a natural medium composed of germinated barley extract, glucose, and germanium mineral water having a pH of 6.5 was used. The mushroom bacteria were added to the natural medium in an Erlenmeyer flask and cultured at 28 ° C for 7 days. After cultivation was completed, the mushroom cultured in a 30 L fermenter comprising aeration device, hydrogen ion concentration control device, and temperature controller was placed, and the rotation speed of the agitating blade of the aeration agitator was rotated at a rate of 400 revolutions per minute, Lt; / RTI >

(S20): Germinated grains were obtained by immersing grains in germanium mineral water having a pH of 6.5, germinated and sterilized. Preferably, the grain is germinated by selecting at least one of the group consisting of brown rice, yuwoo, sorghum and meso.

The grains attached to the embryo are immersed in germanium mineral water for 24 hours. The germanium mineral water uses 0.5 ppm germanium per kg, which promotes germination and prevents spoilage and oxidation during germination.

Germinated water was impregnated in the mineral waters for 24 hours, and the moisture content of the grains was sterilized and cooled by sterilized mineral water at 121 ° C for 90 minutes at 1.2 atm. After cooling, the mixture is allowed to stand at 23 DEG C for 5 hours. When 1 to 2 hours have elapsed, germination is induced from the embryo of the grain.

The germinated embryos were maintained at a water content of 65%, and then inoculated with liquid seeds. Liquid bacterium was cultivated using natural medium, which was homogenized and sprayed at high pressure on the prepared embryo at a pressure of 2 Kg. Then, it becomes possible to uniformly inoculate the upper and lower parts simultaneously.

(S30): The grains inoculated from the liquid seed culture were cultured in a culture container at 28 DEG C for 30 days. At this time, the relative humidity is maintained at 65%, and automatic forced circulation is used to maintain the temperature and humidity.

The cultured germinated grains are placed in a hood mixer, pulverized for about 5 to 10 minutes, powdered, and lyophilized.

The above freeze-drying is rapid-cooling to -70 캜, followed by drying for 7 days while maintaining the temperature at 30 캜.

(S40): The above-mentioned flour mycelial powder, agricultural products and herbal medicines were pulverized and pulverized with a particle size of 300 mesh to obtain a powder.

The mycelial powder, agricultural products, and medicinal materials of the cereals were 10% by weight of Moroya, 10% by weight of Aronia, 2% by weight of Rhodochrosite, 10% by weight of Mycelium, 6% 2% by weight of soybeans, 2% by weight of soybeans, 2% by weight of kelp, 2% by weight of bellflower, 2% by weight of oyster mushrooms, 2% by weight of shiitake mushrooms, 2% by weight of wheat germ, 2% by weight of wheat germ, 2% by weight of wheat germ, 2% by weight of wheat, 2% by weight of clove, 2% 2% by weight of sulfuric acid, 2% by weight of sulfuric acid, 2% by weight of Angelica keiskei, 2% by weight of Bacillus subtilis, 2% by weight of fasting agent, 2% by weight of ginseng and 2% by weight of Korean ginseng.

(S50): The powder obtained in the above step (S40) is put into a fermenter and fermented for 7 days. The composition obtained after the fermentation was put into a steamer and steamed at a temperature of 90 ° C for 9 hours and then dried in a drier at a temperature of 70 ° C for 9 hours to obtain a fermented composition.

(S60): The fermentation composition obtained in the above step (S50) is finely pulverized by a pulverizer, and then filtered through a 100-mesh screen. 1 L of water was added to 1 kg of the pulverized product obtained after the filtration, and the mixture was heated with stirring at 95 캜 for 4 hours to obtain an extract. The extract was centrifuged at 2,500 rpm for 10 minutes to precipitate the residue. After the precipitated residue was removed, the obtained extract was concentrated under reduced pressure at 60 ° C under 700 mmHg, and lyophilized to obtain a fermentation-line-type composition.

[Comparative Example] For comparison of the Fermentation wire composition

Comparative examples of the fermentation-line-type composition of the present invention were prepared according to the prior art by mixing with the following composition.

7 ~ 43% of pork potatoes, 10 ~ 15% of brown rice, 10 ~ 15% of whole beans, 2 ~ 4% of onion, 3 ~ 5% of gugija, 3 ~ 5% of omija, 3 ~ 5% , 4 ~ 6% of green ginseng, 3 ~ 5% of Hwangjeong, 2 ~ 4% of green tea, 4 ~ 6% of green tea, 3 ~ 5% of ginseng, 3-5% of ginseng, 3-5% of ginseng, 2-4% To prepare a composition.

[Test Example] Confirmation of improvement effect of anti-cancer, anti-diabetes and immunity enhancement

In order to confirm the effect of the fermentation-line composition for anticancer, antidiabetic and immunity enhancement fermented by mixing agricultural products and cereal mycelium of the present invention, the fermentation produced by <Examples 1 to 3 and <Comparative Example> A total of 50 patients (25 men and 25 women) with polyuria, weight loss, weakness, and hypertension due to cancer and diabetes were evaluated using a synergistic composition for 6 months. The sensory evaluation for the alleviation of polyuria, weight and physical fitness and improvement of blood pressure was carried out by a questionnaire consisting of 5 points scale, and it was rated as 5 excellent, 4 good, 3 average, 2 poor and 1 very bad . The evaluation scores are shown in [Table 1] to [Table 3].

Improved symptoms Evaluation items Example 1
Composition Example 2
Composition Example 3
Composition Comparative example
Composition Alleviate polyuria 4.41 4.73 4.94 2.18

While applying the fermentation-line composition of the present invention and the composition of the comparative example to a cancer patient and a diabetic patient, the amount of water and the amount of fecal matter were measured once every three days.

As a result, the patients who applied the composition of the present invention had a significantly decreased amount of water and fecal matter compared to the patients to which the composition of the comparative example was applied, although the symptoms of the polyuria were still present in the composition of the comparative example. In particular, the composition of Example 3 of the present invention was excellent in alleviating the symptoms of polyuria.

Therefore, it has been confirmed that the fermentation-line-type composition of the present invention can improve the symptoms of diabetes mellitus, which is the main symptom of diabetes.

Blood pressure improvement Evaluation items Example 1
Composition Example 2
Composition Example 3
Composition Comparative example
Composition Blood pressure improvement 4.34 4.51 4.81 2.43

Blood pressure was measured once every three days while applying the fermentation-line composition of the present invention and the composition of the comparative example to cancer patients and diabetic patients.

As a result, the blood pressure of the patient to which the composition of the present invention was applied was significantly lower than that of the patient to which the composition of the comparative example was applied. Particularly, the blood pressure-improving effect on the composition of Example 3 of the present invention was excellent.

Thus, it has been confirmed that the fermentation-line-type composition of the present invention can improve the blood pressure of cancer patients and diabetic patients.

Improve your weight and physical fitness Evaluation items Example 1
Composition Example 2
Composition Example 3
Composition Comparative example
Composition Improve your weight and physical fitness 4.27 4.32 4.73 2.37

Body weight was measured once every 7 days while applying the fermentation-line composition of the present invention and the composition of the comparative example to cancer patients and diabetic patients.

As a result, the composition of the comparative example did not show the effect of improving the body weight and the fitness of the cancer patient and the diabetic patient, so that the effect of the improvement of the body weight and the physical strength could not be seen in the above patients.

However, the weight and the physical strength were increased in the patients to which the fermentation-line composition of the present invention was applied. Particularly, the composition of Example 3 of the present invention was excellent in improving the body weight and the physical strength.

Therefore, the fermentation-line composition of the present invention shows that it is possible to prevent the body weight and the decrease of the body weight, and it is confirmed that the composition improves the immunity enhancement.

As described above, the present invention is not limited to the above-described embodiments, but is merely an example for the anticancer, anti-diabetic, immunostimulatory fermental-line composition and the preparation method thereof, which are fermented by mixing agricultural products and cereal mycelium It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present invention as defined by the following claims and their equivalents. , The invention is only defined by the scope of the claims.

Claims (7)

After the addition of the mycelium of mycelium and the mycelium of mycelium, which are cereal mycelium, to the basic compositions Moroheya, Aronia and Sasa, they are fermented,
Characterized in that it comprises 8 to 86.5% by weight of Moroheya, 5 to 30% by weight of Aronia, 0.5 to 16% by weight of Acanthaceae, 6 to 23% by weight of brown rice mycelium and 2 to 23% Antitumor agent, antidiabetic agent, and immune enhancing fermentation-line composition fermented by mixing mycelium.
The mycelium of rice husk, mycelium of mycelium, and mycelium of mycelium, which are the mycelium of grain, are added to Moroheya, Aronia,
Wherein the grain mycelium further contains a mycelium-grown mycelium and a meso-state mycelium,
Wherein said mycelium is from 8 to 82.5% by weight, Aronia is from 5 to 18% by weight, fromage is from 0.5 to 13% by weight, from 6 to 17% by weight of brown rice mycelium, from 2 to 17% And 2 to 13.5% by weight of meso-situation mycelia. The fermentation-safe composition for anticancer, antidiabetic and immunity enhancing fermented by mixing agricultural products and cereal mycelia.
The mycelium of rice husk, mycelium of mycelium, and mycelium of mycelium, which are the mycelium of grain, are added to Moroheya, Aronia,
Wherein the grain mycelium further contains a mycelium-grown mycelium and a meso-state mycelium,
In the basic composition, there are added jujube, kelp, bellflower, oyster mushroom, shiitake, cabbage, leek, liquorice, sugarcane, dermis, wheat, clove, liquorice, , Baeksoo Oh, deity, Sammyung, and Ulgum,
The mycelia of the present invention can be obtained by mixing 8 to 70% by weight of Moroheya, 5 to 11% by weight of Aronia, 0.5 to 2% by weight of Rhodochrosite, 6 to 11% 0.5 to 2% by weight of seaweed, 0.5 to 2% by weight of sea tangle, 0.5 to 2% by weight of seaweed, 0.5 to 2% by weight of plumeria, 0.5 to 2% by weight of oyster mushroom, 0.5 to 2% 0.5 to 2% by weight of wheat, 0.5 to 2% by weight of wheat, 0.5 to 2% by weight of leek, 0.5 to 2% by weight of acid, 0.5 to 2% 0.5 to 2% by weight of jasmine, 0.5 to 2% by weight of jasmine, 0.5 to 2% by weight of jasmine, 0.5 to 2% by weight of soil, 0.5 to 2% 0.5 to 2% by weight, 0.5 to 2% by weight, 0.5 to 2% by weight, 0.5 to 2% by weight, And 0.5 to 2% by weight of a fermented beverage comprising a mixture of agricultural products and cereal mycelia.
A step (S10) of culturing the condition mushroom germ as a liquid seed germ;
Inoculating said grains with said liquid seed bacterium (S20);
Culturing, lyophilizing and pulverizing the inoculated grains to obtain a grain mycelium powder (S30);
(S40) a step of adding agricultural products and herbal medicines to the cereal flour material powder and pulverizing the powder to obtain a powder;
(S50) of obtaining the fermented composition by fermenting, steam-drying and drying the powder obtained in the step S40; And
(S60) of extracting the fermented composition obtained in the step (S50). The method for producing a fermented starch composition for anti-cancer, anti-diabetic and immunity enhancing fermented by mixing agricultural products and cereal mycelia.
5. The method of claim 4,
In step (S10), the liquid seed bacterium is cultured in a natural medium composed of germinated barley extract and glucose 6.5 pH germanium mineral water. The fermentation-safe composition for anticancer, antidiabetic and immune enhancement fermented by mixing agricultural products and cereal mycelia Gt;
5. The method of claim 4,
Wherein the grains are immersed in germanium mineral water in the step (S20), wherein the germanium mineral water contains 0.2 to 0.8 ppm of germanium per kg, and the agricultural and granular mycelium is mixed with the germanium mineral water to ferment anticancer, &Lt; / RTI &gt;
5. The method of claim 4,
The powder obtained in the step S40 is added to a special fermentation tank equipped with a HEPA filter and a 0.45 mu m filter to ferment the fermented product. The fermented product of the fermented product of the anticancer, antidiabetic and immunity promoting fermented product mixed with agricultural products and cereal mycelia Gt;

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