KR20130130580A - Composition for preventing or treating gout containing mixed medicinal herbs extracts and method of preparing the extracts - Google Patents

Abstract

The present invention relates to a composition for preventing or treating gout containing mixed medicinal herbs extract as an active ingredient and a method for preparing the same. More specifically, the method for preparing the composition for preventing or treating gout containing mixed medicinal herbs extract as an active ingredient comprises the steps of: (1) adding 1-5wt% of silver vine, 1-5wt% of glycyrrhiza uralensis fischer, 1-5wt% of paeony, and 90-95wt% of water to a predetermined size of a pressure cooker and hot pressing in order to obtain hot water extract; (2) emitting pressed air produced inside the pressure cooker; and (3) filtering the hot water extract and collecting filtrate. According to the composition for preventing or treating gout containing mixed medicinal herbs extract as an active ingredient and the method for preparing the same suggested by the present invention, the composition lowers concentration of plasma uric acid and prevents or treats gout by including the mixed medicinal herbs extract of silver vine, glycyrrhiza uralensis fischer, and paeony. [Reference numerals] (S100) Step of adding 1-5wt% of silver vine, 1-5wt% of glycyrrhiza uralensis fischer, 1-5wt% of paeony, and 90-95wt% of water to a predetermined size of a pressure cooker and hot pressing in order to obtain hot water extract;(S200) Step of emitting pressed air produced inside the pressure cooker;(S300) Step of filtering the hot water extract and collecting filtrate;(S400) Step of reheating the filtrate

Description

Gout prevention or treatment composition comprising a mixed medicinal herb extract as an active ingredient and a method for producing the same

The present invention relates to a composition for preventing or treating gout comprising a mixed medicinal herb extract as an active ingredient, and more particularly, a composition for preventing or treating gout comprising a mixed medicinal extract of Cauliflower, licorice and peony as an active ingredient and its preparation It is about a method.

Gout is an increase in the concentration of uric acid (a product of the body's metabolism of purine, which is ingested through food) in the blood, resulting in the addition of uric acid (ureate in the form of uric acid in the blood, body fluids, and joint fluids). Present) is a metabolic disease in which crystals are deposited on cartilage, tendons and surrounding tissues of joints. The cause of the increase in the concentration of uric acid in the blood may be a large amount of excessive production of uric acid or reduced uric acid excretion, there may be a variety of causal diseases for each case, the cause may not be identified.

These gouts present four typical symptoms of: 1) asymptomatic hyperuricemia, 2) acute gouty arthritis, 3) intermittent gout, and 4) chronic nodular gout. More specifically, the level of serum uric acid in asymptomatic hyperuricemia , But symptoms such as arthritis, gout nodules and uric acid kidney disease do not appear yet. In the stage of acute gouty arthritis, the first gout or kidney disease occurs after hyperuricemia, which usually lasts for at least 20 years, and in the intermittent gout phase, most patients develop a second attack between six months and two years. In chronic nodular gout stages, gout nodule formation and gout attacks increase in proportion to the degree and duration of hyperuricemia.

Currently, uric acid excretion accelerators such as allopurinol, probenecid, and the like are mainly used to improve or prevent gout and to improve lifestyles such as weight control, sobriety, and overeating. However, these drugs can cause side effects such as skin rashes, gastrointestinal disorders, allergic reactions to drugs such as liver and kidney damage, and changes in blood counts. Therefore, recently, various studies have been conducted with increasing interest in therapeutic agents for preventing or treating gout using natural extracts (see Patent Publication No. 10-2010-0122309).

On the other hand, Actinidia polygama is a fruit of the deciduous vine, a deciduous vine plant belonging to the genus Actinidiaceae, sucrose, mucus, starch, protein, tannin, organic acid, vitamin C, vitamin A, vitamin P is contained, and it is known to be used for the treatment of jigal (,), sunburn fever (解 煩熱) and urinary stones (泌尿 器 結石).

Licorice is a perennial herb belonging to the legume (Leguminosae) family, and contains sweeteners such as glycyrigin and flavonoids such as lycuritin, sucrose, glucose, mannitol, and asparagine. And it is known that the excellent antioxidant capacity is effective in oozing, wetting, growth and the like, and is also used as an antidote and an inflammatory agent.

Peony is a perennial herbaceous herb that belongs to the Ranunculaceae family, which is also known as a persimmon flower. It is known to be used for the treatment of amenorrhea, trauma, nasal bleeding, inflammation, boils and wounds, and pain relief of the chest and ribs for the purpose of inflammation, analgesic and dysmenorrhea. .

As a result of the above, the development of a composition for preventing or treating gout has become an important problem, and the use of cabbage, licorice and peony as such therapeutic agents is of interest.

The present invention has been proposed to solve the above problems of the conventionally proposed methods, by including a mixed medicinal herb extract of Cabbage, Licorice and Peony can lower or lower the concentration of uric acid in the blood to prevent or treat gout It is an object of the present invention to provide a composition for preventing or treating gout comprising the extract as an active ingredient and a method for producing the same.

Composition for preventing or treating gout according to the characteristics of the present invention for achieving the above object,

Characterized by its constituent features including an extract of the mixed medicinal herb, licorice and peony as an active ingredient.

Preferably, the mixed medicinal extract,

It can be extracted using 5 to 15 times the weight of water compared to the total weight of the leek, licorice and peony.

Preferably, the mixed medicinal extract,

It may include 1-5% by weight, 1-5% by weight licorice and 1-5% by weight peony.

Method for producing a composition for preventing or treating gout comprising a mixed medicinal extract according to the characteristics of the present invention for achieving the above object as an active ingredient,

(1) adding 1-5% by weight, 1-5% by weight licorice, 1-5% by weight peony and 90-95% by weight water to a pressure cooker of a predetermined size to obtain a hot water extract by hot pressing;

(2) discharging the compressed air generated inside the pressure cooker; And

(3) filtering the hot water extract and recovering the filtrate.

Preferably,

(4) The method may further include reheating the filtrate.

Preferably, the step (1)

2.5 atm, 115 to 125 ℃ can be carried out for 2.5 to 3 hours.

According to the composition for preventing gout or treatment comprising a mixed medicinal herb extract proposed in the present invention as an active ingredient and a method for preparing the same, by preventing the gout by lowering the concentration of uric acid in the blood by including a mixed medicinal extract of Caesar, Licorice and Peony Or can be treated.

1 is a view showing a process of manufacturing a composition for preventing or treating gout containing a mixed medicinal herb extract according to an embodiment of the present invention as an active ingredient.
Figure 2 is a view showing the results of experiments to change the blood uric acid concentration in the composition for preventing or treating gout containing the mixed medicinal herb extract according to an embodiment of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings, in order that those skilled in the art can easily carry out the present invention. In the following detailed description of the preferred embodiments of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear. In the drawings, like reference numerals are used throughout the drawings.

In addition, in the entire specification, when a part is referred to as being 'connected' to another part, it may be referred to as 'indirectly connected' not only with 'directly connected' . In addition, the term 'comprising' of an element means that the element may further include other elements, not to exclude other elements unless specifically stated otherwise.

In the present specification, the term "active ingredient" includes a substance or a group of substances (a pharmacologically active ingredient or the like which is expected to express the efficacy effect of the composition directly or indirectly by inherent pharmacological action). Means a main component).

Actinidia polygama is a fruit of the deciduous vine, a deciduous vine plant belonging to the genus A. quince and Actinidiaceae. Sucrose, mucosa, starch, protein, tannin, organic acid, vitamin C, vitamin A, and vitamin P. It is known to be used for the treatment of jigal (,), sunburn fever (解 煩熱) and urinary stones (泌尿 器 結石).

Licorice is a perennial herb belonging to the legume (Leguminosae) family, and contains sweeteners such as glycyrigin and flavonoids such as lycuritin, sucrose, glucose, mannitol, and asparagine. And it is known that the excellent antioxidant capacity is effective in oozing, wetting, growth and the like, and is also used as an antidote and an inflammatory agent.

Peony is a perennial herbaceous herb that belongs to the Ranunculaceae family, which is also known as a persimmon flower. It is known to be used for the treatment of amenorrhea, trauma, nasal bleeding, inflammation, boils and wounds, and pain relief of the chest and ribs for the purpose of inflammation, analgesic and dysmenorrhea. .

The present inventors experimentally confirmed that the mixed medicinal herb extract of Licorice, Licorice and Peony lowers the concentration of uric acid in the blood and shows an excellent effect on the prevention or treatment of gout. Medicinal extracts have been found to be a very safe drug for the human body to complete the present invention.

That is, the composition for preventing gout or treatment comprising a mixed medicinal herb extract according to an embodiment of the present invention as an active ingredient is characterized in that it comprises a mixed medicinal herb, licorice and peony as an active ingredient. The mixed medicinal herb extract can be extracted using water, in particular, purified water as a solvent, and more specifically, it is preferably extracted using 5 to 15 times the weight of water compared to the total weight of seaweed, licorice and peony. In addition, the mixed medicinal herb extract contained in the composition for preventing or treating gout containing the mixed medicinal herb extract according to an embodiment of the present invention is 1-5% by weight, licorice 1-5% by weight and peony 1-5 It is preferable to include the weight percent.

On the other hand, the wormwood, licorice and peony contained in the composition for preventing gout or treatment comprising the mixed medicinal extract as an active ingredient according to an embodiment of the present invention can be used to extract the dry state or as it is natural, in order to increase the extraction efficiency It may also be used by crushing or grinding.

Hereinafter, a method for preparing a composition for preventing or treating gout comprising a mixed medicinal extract according to an embodiment of the present invention as an active ingredient.

1 is a view showing a process diagram of a method for preparing a composition for preventing or treating gout containing the mixed medicinal extract as an active ingredient according to an embodiment of the present invention. As shown in Figure 1, the method for producing a composition for preventing or treating gout comprising a mixed medicinal herb extract according to an embodiment of the present invention as an active ingredient, 1 ~ 5% by weight, Licorice 1 ~ 5% by weight, peony 1-5% by weight and 90-95% by weight of water to obtain a hot water extract by hot pressing (S100), discharging the compressed air generated in the pressure cooker (S200) and hot water extract It may be configured to include the step of recovering the filtrate by filtering (S300), it may further comprise the step of reheating the filtrate (S400).

In step S100, we put a litter, licorice, peony and water into a pressure cooker and pressurized at high temperature to obtain a hot water extract of the mixed medicine. More specifically, 1 to 5% by weight, licorice 1-5%, peony 1-5% and water 90-95% by weight, the inside of the pressure cooker at 2.5 atmospheres, 115-125 ℃ temperature range It is preferable to obtain hot water extract of the mixed medicine by hot pressing for 2.5 to 3 hours while maintaining.

In step S200, the compressed air generated inside the pressure cooker in the process of performing step S100 is discharged, and more specifically, it is preferable to discharge the compressed air 1 to 2 hours after the step S100 is finished.

In step S300, the filtrate is recovered by filtering the hot water extract of the mixed medicine obtained in step S100. That is, the hot water extract is filtered using a juicer, a squeezed filter, or the like to remove the solids of the cauliflower, licorice and peony contained in the extract.

In step S400, the filtrate filtered by step S300 is reheated. That is, even though the filtration in step S300 may still contain the algae, licorice and other impurities that interfere with the effect of the peony, for this purpose, in step S400, by heating the filtrate filtered in step S300 Eliminate licorice and other impurities that interfere with the effectiveness of the peony.

Meanwhile, the composition for preventing or treating gout containing the mixed medicinal herb extract according to one embodiment of the present invention prepared as the active ingredient as an active ingredient may be individually packaged by an appropriate dose or packaged in a container. .

In addition, the composition comprising the mixed medicinal extract according to the present invention may further comprise suitable carriers, excipients and diluents commonly used in the manufacture of pharmaceutical compositions.

The pharmaceutical dosage forms of the pharmaceutical compositions comprising the mixed medicinal extracts according to the present invention may be used in the form of their pharmaceutically acceptable salts, and may also be used alone or in combination with other pharmaceutically active compounds as well as in a suitable collection. have.

The pharmaceutical composition comprising the mixed medicinal compound extract according to the present invention may be formulated into oral formulations such as powders, granules, tablets, capsules, suspensions, emulsions, syrups and aerosols, external preparations, suppositories and sterilized injection solutions Can be used. Examples of carriers, excipients and diluents that can be included in the composition including the mixed medicinal extract according to the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin , Calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. A diluent or excipient such as a commonly used filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant may be used. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and these solid preparations may contain at least one excipient such as starch, calcium carbonate and sucrose in a mixed medicinal extract. ) Or lactose, gelatin and the like can be mixed and prepared. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Oral liquid preparations include suspensions, solvents, emulsions, and syrups. In addition to the commonly used simple diluents, water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be prepared. Can be. Preparations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories, and the like, and non-aqueous solvents and suspensions include vegetable oils such as propylene glycol, polyethylene glycol and olive oil. Injectable esters such as ethyl oleate, and the like can be used.

The preferred dosage of the mixed medicinal extract according to the present invention depends on the condition and weight of the patient, the extent of the disease, the form of the drug, the route of administration and the duration, and may be appropriately selected by those skilled in the art. However, preferably the mixed medicinal extract according to the present invention is administered at 0.001-100 mg / kg body weight per day, more preferably 0.01-40 mg / kg body weight. The administration may be carried out once a day or divided into several times. The dose is not intended to limit the scope of the invention in any way.

The mixed medicinal extract according to the present invention can be administered to mammals such as rats, mice, livestock, and humans in various routes. The method of administration is not limited and may be administered, for example, by oral, rectal or intravenous, intramuscular, subcutaneous, intrauterine epidural or cerebrovascular (intracerbroventricular) injection.

The present invention is explained in more detail by the following examples, but the present invention is not limited in any way by the following examples.

Manufacture of compositions for the prevention or treatment of gout

300 g of Licorice fruit, 200 g of licorice, 500 g of peony, and 14 L of water were put in a pressure cooker, and a hot water extract was obtained while pressurizing at 2.5 atm and 120 ° C. for 3 hours. After 2 hours, the compressed air was discharged, the solids were removed using a filtration compressor, and the composition was reheated to 90 to 100 ° C.

Hereinafter, the effects of the present invention will be described in more detail through experimental examples, but the scope of the present invention is not limited by the following experimental examples.

[Experimental Example 1]

Blood uric acid concentration change experiment

In order to confirm the anti-gout effect by the composition for preventing or treating gout containing the mixed medicinal extract according to the present invention as an active ingredient, the animal experiment was carried out as follows.

1. Subject and Period

The subjects of this experiment were 100-200 g 6-week-old rats (SD rats), and the experimental period was 7 days.

2. Experimental method

Experimental rats (SD rats) were divided into five test dogs and one control group, respectively, and the experimental group was orally administered with 100 mg / kg of the composition prepared in Example 1 for one week, and the control group was administered saline. One hour before the last dose, 280 mg / kg of potassium oxonate was injected intraperitoneally to induce blood uric acidosis. After the administration and injection, the animals were sacrificed by cardiac collection to collect blood, and then plasma was separated. The content was measured.

3. Results

The results of measuring blood uric acid in the blood collected from the animals after the administration and injection are shown in FIG. 2. As shown in Figure 2, the experimental group showed a significant difference in the content of uric acid in the blood compared to the control group. That is, the experimental group administered the composition according to the present invention showed a blood uric acid lowering effect of 55% or more than the control group. Therefore, it was confirmed that the composition for preventing or treating gout containing mixed medicinal herb extract of Lichen, Licorice and Peony according to the present invention as an active ingredient is very effective in preventing or treating gout.

[Experimental Example 2]

Toxicity Test

Toxic effect was found even after 7 days of injecting 20 g / kg, 10 mg / kg and 1 mg / kg of the gout preventing or treating composition prepared in Example 1 into three experimental rats (SD rats). There was no death. Therefore, the composition for preventing or treating gout containing the mixed medicinal extract according to the present invention as an active ingredient was confirmed to be a safe drug.

The present invention may be embodied in many other specific forms without departing from the spirit or essential characteristics of the invention.

S100: step 1 to 5% by weight, licorice 1 to 5% by weight, peony 1 to 5% by weight and water 90 to 95% by weight in a pressure cooker of a certain size to obtain a hot water extract by high pressure
S200: discharging the compressed air generated inside the pressure cooker
S300: filtering the hot water extract to recover the filtrate
S400: step of reheating the filtrate

Claims (6)

Gout prevention, a composition for preventing or treating gout comprising a mixed herbal extract of licorice and peony as an active ingredient.
The method of claim 1, wherein the mixed medicinal extract,
Characterized in that the extract using water of 5 to 15 times the weight of the total weight of licorice, licorice and peony, composition for preventing or treating gout.
The method of claim 1, wherein the mixed medicinal extract,
1-5% by weight, licorice 1-5% by weight and peony 1-5% by weight, characterized in that the composition for preventing or treating gout.
(1) adding 1-5% by weight, 1-5% by weight licorice, 1-5% by weight peony and 90-95% by weight water to a pressure cooker of a predetermined size to obtain a hot water extract by hot pressing;
(2) discharging the compressed air generated inside the pressure cooker; And
(3) characterized in that it comprises the step of recovering the filtrate by filtering the hot water extract, gout prevention or treatment composition production method comprising a mixed medicinal extract as an active ingredient.
5. The method of claim 4,
(4) characterized in that it further comprises the step of reheating the filtrate, gout prevention or treatment composition production method comprising a mixed medicinal herb extract as an active ingredient.
4. The method of claim 3, wherein step (1)
Method for producing a composition for preventing or treating gout comprising a mixed medicinal herb extract as an active ingredient, characterized in that it is carried out at 2.5 atm, 115 to 125 ℃ for 2.5 to 3 hours.

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