KR20120140383A - Space sterilizing composition comprising thyme essencial oil - Google Patents

Abstract

The present invention relates to a composition for space sterilization, comprising a thyme essential oil which has high volatility and continuously smells and has antibacterial effect against various microorganisms present in the surroundings. .

Description

Space Sterilizing Composition Comprising Thyme Essencial Oil

The present invention relates to a composition for space sterilization which can be applied as an antimicrobial fragrance having antibacterial effects on various microorganisms present in the air by volatilization rather than contact sterilization.

Essential oil (Essential Oil) is the basic substance of aromatherapy and refers to volatile essential oil (Volatile Oil) extracted from the stems, roots, fruits, and bark of aromatic plants (Herb).

Essential oils are excellent for sterilization, disinfection and deodorization, so they can be used in various ways at home. For example, lavender, peppermint, rosemary, lemon, tea tree and eucalyptus essential oils have a deodorizing or deodorizing effect.

Avoid oils such as eucalyptus, lemon, geranium, lemongrass, and lavender when you want to stay away from pests, especially mosquitoes and flies, in the summer, and to avoid insects and mosquitoes when camping outdoors.

Protein essential oils have strong antibacterial properties, help blood circulation and increase immunity. In addition, house dust mite, one of the main causes of atopy, has an excellent effect of repelling mites and neutralizes volatile organic compounds that cause sick house syndrome. Greatly relieves many itching of atopic or allergic diseases. It also has excellent deodorizing effect, which relieves sick house syndrome and makes indoor air comfortable.

The fragrances are intended to give a uniform and lasting scent for a relatively long time in a certain place within a certain space and are not related to the antibacterial effect.

Korean Patent Registration No. 10-0611248 discloses an antibacterial and antifungal composition comprising plant essential oils, wherein plant essential oils are thyme white, thyme red, cinnamon bark, and cade. ), Calamus, Chamomile Roman and Howood, Bay, Lemongrass, Pimento berry, Litsea cubeba, Coriander (Coriander) et al. May be used. At this time, the antimicrobial activity test of Experimental Example 1, dropping the plant essential oil on the sterile paper disk (diameter 8 mm) in the medium and put it on the medium, incubated for 24 hours at the appropriate temperature according to each strain, and then in plant essential oil The antimicrobial activity was measured while measuring the diameter of growth stop ring of bacteria. The antimicrobial activity in this patent is measured in an environment in which plant essential oils and microorganisms are in direct contact, which is different from the concept of space sterilization to be obtained in the present invention.

On the other hand, the floating bacteria are microorganisms that multiply themselves as floating bacteria in indoor air, causing allergies or respiratory diseases. These suspended bacteria survive by adhering to dust, water vapor, and the like, are moist, and have a fast propagation force in the range of 20 to 35 ° C. Therefore, it is necessary to reduce the amount of dust on floor mats, window cracks, beddings, etc., and to regularly prevent the source of pollutants by regularly ventilating and cleaning and disinfecting them.

At present, the sterilization of air to remove suspended bacteria is made by installing an air conditioner or an air cleaner. The air conditioner or air purifier is equipped with a sterilization filter or an ultraviolet irradiation device in the device to sterilize the microorganisms present in the air, and recently, a device using various substances having an antibacterial effect has been developed.

Republic of Korea Patent Publication No. 2009-81306 discloses that by periodically spraying the silver nano aqueous solution or suspension, it is possible to increase the life of the filter device, increase the sterilization, antibacterial, and deodorizing effect of the indoor air.

Korean Patent Laid-Open Publication No. 2007-99981 discloses a bacterium, such as avian influenza, by sterilizing bacteria in the air by including kimchi lactobacillus fermentation in at least one member including a part in contact with indoor air sucked and discharged in an air conditioner. It is disclosed that it can maintain a comfortable indoor air with an antiviral effect.

Korean Patent Registration No. 10-0611248; Korean Patent Publication No. 2009-81306; Republic of Korea Patent Publication No. 2007-99981

The inventors of the present invention, while searching for a species having a plant essential oil having an antimicrobial effect, confirmed that the thyme (thyme, thyme) essential oil has a bactericidal effect on the space.

Accordingly, an object of the present invention is to provide a composition for space sterilization comprising time.

In order to achieve the above object, the present invention provides a composition for space sterilization comprising a thyme essential oil.

The space sterilizing composition according to the present invention has high volatility and can be applied as an antimicrobial fragrance because it has an antimicrobial effect on various microorganisms present in the surroundings due to continuous fragrance upon exposure to the air rather than by direct contact.

Hereinafter, the present invention will be described in detail.

As used throughout this specification, 'space sterilization' means that there is an antimicrobial effect against microorganisms that exist in a space in a closed or open state, that is, bacteria or suspended bacteria including viruses.

It is native to the Mediterranean coast, West Asia and North Africa, and belongs to the Lamiaceae family, which grows to about 30 cm in height. Stems come from the roots with a lot of small roots. The leaves are 5 ~ 9mm long, about 3mm wide, long oval, and the edges of the leaves are bent inward and have fine hairs. From 3 to 6 purple or pink flowers in short stalks bloom in May-October and harvest the branches with flowers between May and June.

Thyme has a sensational flavor that gives the dish a deep flavor and is used mainly to remove the smell of meat. The essential oil, thymol, extracted from thyme, has antiseptic, antiseptic, and antibacterial effects on Gram-positive bacteria, and is effective for respiratory diseases such as colds and coughs. Time oil is known to relieve bronchial spasms and to act as an expectorant.

Time essential oil proposed in the present invention is prepared by a conventional plant essential oil manufacturing method.

As an essential oil manufacturing method, all kinds of conventional methods may be used. For example, steam distillation, in which essential oils are discharged to a temperature lower than the actual boiling point, expression such as citrus fruits, and compression to obtain essential oils by compressing the skin In case of high price, low essential oil content, unstable heat, and high water soluble content, it is adsorbed by absorbing in nonvolatile solvent such as fat and volatile solvent (hexane, ethyl alcohol, benzene, etc.) Solvent extraction, which extracts fragrance components, exudation, which collects sap from plant stems, rhizomes, and leaches, and supercritical extraction (CO2 extracton). It is not limited.

In addition, it is good to obtain only components having excellent low molecular weight volatility by using steam distillation, and commercialized essential oils can be purchased and used.

In this case, the time for essential oil extraction may be at least one site selected from the group consisting of whole plants, leaves, stems, bark, leaves, branches, cores, roots, resins, fruits and seeds.

The composition for space sterilization comprising the essential oil according to the present invention as an active ingredient shows excellent antimicrobial activity against various microorganisms such as bacteria or viruses, for example, pathogenic bacteria and toxin-producing fungi.

Preferably, Escherichia coli ), Staphylococcus Stability Philo such aureus), Staphylococcus epidermidis (Staphylococcus epidermidis) Coconut (Staphylococcus sp . ), Bacillus subtilis subtilis), Bacillus cereus (Bacillus Bacillus cereus, such as) (Bacillus sp . ), Candida albicans (Candida albicans ) Candida sp . ) Have high antimicrobial activity.

According to a preferred experimental example of the present invention, the space sterilization effect using tea tree, turpen, Cinnanon Bark, rosemary oil, and oregano (Origanum, Marjoram) essential oil which is known to have excellent antimicrobial effect with thyme essential oil. As a result of the measurement, it was confirmed that thyme essential oil has an excellent bactericidal effect against E. coli, Staphylococcus, Bacillus and Candida.

The space sterilization composition can be applied to various fields, and can be applied as a fragrance, food additives, cosmetics, coatings, and the like, and preferably can be applied as a fragrance or a coating agent.

When used as a fragrance, the content of thyme essential oil may be 0.001 to 99% by weight, preferably 0.1 to 20% by weight. However, the content of the thyme essential oil is not limited to the above values, it is more preferable to adjust appropriately according to the method of use and formulation.

The fragrance and sterilization strength are adjusted according to the content of thyme essential oil, and the composition for space sterilization has an effective amount of the aroma treatment at 295 ml / m ³ or more (about 270 ppm) in terms of concentration in air.

The formulations may be prepared in the form of solutions, suspensions, fragrances, aerosols, ointments, or matrix gels and sterilize the space by direct spraying, fumigation, or aromatherapy.

In one example, the gel fragrance is divided into an aqueous fragrance based on water and an oil based fragrance based on an organic solvent. The aqueous fragrance has a quick volatilization of the fragrance, the oily fragrance has the advantage of maintaining the fragrance for a long time.

When used as a gel fragrance, it may further comprise conventional solubilizers, gelling agents, gel strengthening agents, surfactants, dyes, flavoring agents, and preservatives with thyme essential oils.

The solubilizer may be a water-soluble solvent such as water, ethanol, isopropanol, acetone, ethylene glycol methyl ether, ethylene glycol ethyl ether, ethylene glycol butyl ether, polyoxy alkylene alkylphenyl ether, polyoxy alkylene glycol fatty acid ester, polyoxy alkyl Conventional solubilizers may be used, such as renda alcohol fatty acid ester fatty acid alkanolamide, trialkyl amine oxide, or alkyl sulfate esters.

The gelling agent may be a fatty acid metal salt such as aluminum octylate, calcium octylate, sodium octylate and aluminum hexanoate, or gelatin.

In addition, gel strengthening agents include polyhydric alcohols such as ethylene glycol, propylene glycol, glycerin, trimethylolpropane, sorbitol, polyglycerol; Sugars such as glucose, fructose, mannose and trehalose; Alternatively, polyell polyol having an alkylene oxide added thereto may be used.

In addition, the space sterilizing composition according to the present invention can be used as a coating agent. When used as a coating agent, it can be applied to all human living spaces such as interior and exterior walls of buildings, building materials, interior of vehicles, interiors without windows, etc. Preferably, the space sterilizing composition is more useful for coating or coated wallpaper. It is expected to be high.

When applied as a coating, it may further include a solvent, a binder, and, if necessary, a photocatalyst such as thyme essential oil, which can dissolve or disperse.

Such a space sterilizing composition may be installed in a space that is easily contaminated, such as an indoor space, an office, a bathroom, or the like to maintain a comfortable space when applied to a fragrance or a coating agent.

Specifically, not only in the home, but also in immunized infants, postpartum care centers where infants stay, pediatrics, entrances to day care centers, daycare centers, kindergartens, and business stores that require continuous sterilization and deodorization management, office buildings where many people enter, and public places and It can be used in the public restroom space where there is a risk of odor and bacterial infection, so that the standard of microorganism can be managed within the acceptable standard, and the time-specific scent can be emitted continuously to maintain a more pleasant environment.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the scope of the present invention is not limited to the following examples.

[Example]

Example 1

Steam distillation was performed to obtain essential oils from thyme, tea tree, turpen, Cinnanon Bark, rosemary oil, and oregium (Origanum, Marjoram). In order to confirm the bactericidal effect on the microorganisms present in the indoor air of each plant essential oil was performed as follows.

The indoor air was sucked into a certain amount by a bio air sampler and collided with a medium prepared in advance to collect microorganisms in the air. At this time, agar medium was used.

Agar medium was used to prepare a 90 × 20 mm petri dish and the total volume of the medium was adjusted to be within 20% of the interior space of the petri dish. The initial concentration of the bacterial suspension was then 1 to 5 for aerobic strains. x 10 ⁵ CFU / ml, the anaerobic strain in the initial concentration was 1 × 10 ⁶ CFU / mL was plated on the agar medium.

The 10 mm Whatman filter paper was placed in the center of the top cover of the petri dish, and the plant essential oil (about 10-30 ul) was inoculated thereon. At this time, plant essential oils were mixed with distilled distilled water and ethanol (1: 1 volume ratio, Tween20 0.1% (v / v)). The contents of the plant essential oils were used in 25 ml (25%), 50 ml (50%), and 100 ml (100%, single use) such that the total volume of the plant essential oils and the dilutions satisfies 100 ml. The petri dish was then covered with a paraffin film to block contact with outside air, and then cultured in a microbial incubator.

Next, growth inhibition ring (inhibition zone) was measured 24 hours after incubation, and the results are shown in Table 1 below. At this time, the growth germination ring diameter should be removed more than the size of Whatman filter paper is evaluated to have sterilization ability.

Diameter of growth-lowering ring Diameter (mm) density Escherichia coli Stapilocco Course Bacillus Candida time 25% 35 90 40 21 50% 35 90 62 43 100% 75 90 75 52 Cinnamon Bark 25% 20 43 23 35 50% 20 43 35 35 100% 22 53 38 40 Rosemary 25% 28 55 38 25 50% 28 55 40 34 100% 36 65 60 40 oregano 25% 25 53 45 14 50% 27 55 48 32 100% 30 90 54 32 Tea tree 25% 0 0 0 0 50% 0 7 0 25 100% 15 37 30 58

As shown in Table 1, in the case of the time essential oil proposed in the present invention showed excellent antimicrobial activity in all other microorganisms, including E. coli.

The composition for space sterilization according to the present invention can be applied as a fragrance.

Claims (5)

Space sterilizing composition comprising a thyme (Thyme) essential oil. The space of claim 1, wherein the thyme essential oil has an antibacterial effect against Escherichia coli, Staphylococcus sp., Bacillus sp., And Candida sp. Sterilizing composition. The composition for space sterilization according to claim 1, wherein the composition for space sterilization has a formulation of a liquid, suspension, fragrance, aerosol, ointment, or matrix gel. According to claim 1, The space sterilization composition is a space sterilization composition, characterized in that the sterilization of the space by a direct spray method, fumigation, or aroma treatment method. The composition for space sterilization according to claim 1, wherein the composition for space sterilization has an effective amount of aroma treatment method in terms of concentration in air of 295 ml / m ³ or more.