KR20110089223A - 6-진저롤을 주성분으로 하는 생강 조 추출물의 표준화 추출 분획물을 함유하는 퇴행성 뇌질환의 치료 및 예방용 조성물 - Google Patents
6-진저롤을 주성분으로 하는 생강 조 추출물의 표준화 추출 분획물을 함유하는 퇴행성 뇌질환의 치료 및 예방용 조성물 Download PDFInfo
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- KR20110089223A KR20110089223A KR1020100008852A KR20100008852A KR20110089223A KR 20110089223 A KR20110089223 A KR 20110089223A KR 1020100008852 A KR1020100008852 A KR 1020100008852A KR 20100008852 A KR20100008852 A KR 20100008852A KR 20110089223 A KR20110089223 A KR 20110089223A
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- ginger
- standardized
- extract
- fraction
- suspension
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Abstract
Description
도 2는 SG-E, SG-S 및 SG-R 중에 함유된 6-진저롤의 함량을 나타낸 도면이며,
도 3은 SG-S의 뇌 세포 보호 효과를 나타낸 도면이고,
도 4는 SG-S의 HO-1 발현 효과 및 HO 효소 활성 평가를 나타낸 도면이며,
도 5는 SG-S의 HO-1 발현에 의한 세포보호 효과 및 ROS 소거 효과를 나타낸 도면이다.
시료명 | 6-진저롤 함량 (w/w %) |
SG-E | 0.066 |
SG-S | 8.691 |
SG-R | 2.740 |
HO 농도 (ng/ml) | 0.0 | 0.125 | 0.250 | 0.5 | 1.0 | 2.0 | 4.0 | 8.0 |
OD450 | 0.091 | 0.134 | 0.143 | 0.214 | 0.421 | 0.786 | 1.325 | 3.021 |
Claims (11)
- 6-진저롤을 주성분으로 하는 생강의 표준화 추출 분획물을 유효성분으로 함유하는 퇴행성 뇌질환의 예방 및 치료용 약학조성물.
- 제 1항에 있어서, 생강(生薑; Zingiberis Rhizoma Crudus)은 생강과(Zingiberaceae)의 여러해살이풀인 생강(Zingiber officinale Rosc.)의 뿌리줄기인 약학조성물.
- 제 1항에 있어서, 상기 표준화 추출 분획물은 물, 메탄올, 에탄올, 부탄올 등의 저급 알콜 또는 이들의 혼합용매의 극성 용매로 당업계의 통상적인 추출방법으로 추출하여 수득된 생강 조 추출물을 1 내지 10배 부피(v/v)의 물을 가해 현탁액을 제조한 후에 실온 방치 후에 원심 분리하여 수득되는 생강 표준화 침전물 추출 분획물 및 생강 표준화 상등액 추출 분획물을 포함함을 특징으로 하는 약학 조성물.
- 제 1항에 있어서, 상기 생강 조 추출물의 6-진저롤을 주성분으로 하는 표준화 분획물(SG-S)은 건조시킨 생강을 물, 메탄올, 에탄올, 부탄올 등의 저급 알콜 또는 이들의 혼합용매 등의 극성 용매로 가열추출법, 초음파 추출법, 환류 추출법 등의 통상적인 추출방법으로 추출하여 생강 조 추출물을 수득하는 제 1단계; 상기 단계에서 수득한 생강 조 추출물에 증류수, 정제수 등의 통상적인 물을 첨가하여, 충분히 교반하여 현탁액을 제조하는 제 2단계; 상기 현탁액을 상온에서, 12 내지 48시간 동안 방치하여 수용액상 및 현탁액상을 제조하는 제 3단계; 상기에서 제조된 수용액상 및 현탁액상을 용매-용매 분배법을 이용한 분획법, 원심분리기를 이용한 분획법 등의 당업계에 통상적인 분리방법을 이용하여 500 내지 10000 rpm의 회전속도에서 10분 내지 3시간 동안 원심분리를 수행하여 침전물 및 상등액을 각각 수득하는 제 4단계 공정을 포함하는 제조방법을 통하여 수득되는 생강 표준화 침전물 추출 분획물(SG-S) 또는 생강 표준화 상등액 추출 분획물(SG-R)임을 특징으로 하는 약학조성물.
- 제 1항에 있어서, 상기 퇴행성 뇌질환은 뇌졸중, 중풍, 치매, 알츠하이머 질환, 파킨슨 질환, 헌팅턴 질환, 피크(Pick) 질환 또는 크로이츠펠트-야콥(Creutzfeld-Jakob) 질환을 포함함을 특징으로 하는 약학조성물.
- 제 1항에 있어서, 상기 “생강의 표준화 추출 분획물”은 6-진저롤 (gingerol) 지표성분을 1.0 내지 10%(w/w)을 함유함을 특징으로 하는 약학 조성물.
- 제 1항에 있어서, 상기 조성물 총 중량에 대하여 상기 생강 조 추출물의 6-진저롤을 주성분으로 하는 표준화 분획물(SG-S)을 0.1 내지 50% 중량으로 포함함을 특징으로 하는 약학조성물.
- 6-진저롤을 주성분으로 하는 생강의 표준화 추출 분획물을 유효성분으로 함유하는 퇴행성 뇌질환의 예방 및 개선용 건강기능식품.
- 제 8항에 있어서, 분말, 과립, 정제, 캡슐 또는 음료인 건강기능식품.
- 제 8항에 있어서, 상기 생강 조 추출물의 6-진저롤을 주성분으로 하는 표준화 분획물(SG-S)은 상기 생강 조 추출물의 6-진저롤을 주성분으로 하는 표준화 분획물(SG-S)은 건조시킨 생강을 물, 메탄올, 에탄올, 부탄올 등의 저급알콜 또는 이들의 혼합용매 등의 극성 용매로 가열추출법, 초음파 추출법, 환류 추출법 등의 통상적인 추출방법으로 추출하여 생강 조 추출물을 수득하는 제 1단계; 상기 단계에서 수득한 생강 조 추출물에 증류수, 정제수 등의 통상적인 물을 첨가하여, 충분히 교반하여 현탁액을 제조하는 제 2단계; 상기 현탁액을 상온에서, 12 내지 48시간 동안 방치하여 수용액상 및 현탁액상을 제조하는 제 3단계; 상기에서 제조된 수용액상 및 현탁액상을 용매-용매 분배법을 이용한 분획법, 원심분리기를 이용한 분획법 등의 당업계에 통상적인 분리방법을 이용하여 500 내지 10000 rpm의 회전속도에서 10분 내지 3시간 동안 원심분리를 수행하여 침전물 및 상등액을 각각 수득하는 제 4단계 공정을 포함하는 제조방법을 통하여 수득되는 생강 표준화 침전물 추출 분획물(SG-S) 또는 생강 표준화 상등액 추출 분획물(SG-R)임을 특징으로 하는 건강기능식품.
- 건조시킨 생강을 물, 메탄올, 에탄올, 부탄올 등의 저급 알콜 또는 이들의 혼합용매 등의 극성 용매로 가열추출법, 초음파 추출법, 환류 추출법 등의 통상적인 추출방법으로 추출하여 생강 조 추출물을 수득하는 제 1단계; 상기 단계에서 수득한 생강 조 추출물에 증류수, 정제수 등의 통상적인 물을 첨가하여, 충분히 교반하여 현탁액을 제조하는 제 2단계; 상기 현탁액을 상온에서, 12 내지 48시간 동안 방치하여 수용액상 및 현탁액상을 제조하는 제 3단계; 상기에서 제조된 수용액상 및 현탁액상을 용매-용매 분배법을 이용한 분획법, 원심분리기를 이용한 분획법 등의 당업계에 통상적인 분리방법을 이용하여 500 내지 10000 rpm의 회전속도에서 10분 내지 3시간 동안 원심분리를 수행하여 침전물 및 상등액을 각각 수득하는 제 4단계 공정을 포함하는 제 1항의 생강 조 추출물의 6-진저롤을 주성분으로 하는 표준화 추출 분획물을 각각 수득하는 제조방법.
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Cited By (4)
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KR101329341B1 (ko) * | 2011-11-14 | 2013-11-15 | 대한민국 | 백일홍 추출물을 포함하는 소해면상뇌증의 예방 또는 치료용 조성물 |
WO2014025202A1 (ko) * | 2012-08-07 | 2014-02-13 | 씨제이제일제당(주) | 작약, 건강 혼합추출물을 포함하는 치매 및 인지기능장애 예방 또는 치료용 약제학적 조성물 |
KR20170015758A (ko) * | 2015-07-31 | 2017-02-09 | 한국식품연구원 | Schizosaccaromyces pombe를 이용한 생강 발효물 및 이의 용도 |
CN107300593A (zh) * | 2017-07-06 | 2017-10-27 | 成都市中草药研究所(成都市卫生计生药械科技服务中心) | 生姜及其炮制品中姜辣素成分的检测方法 |
-
2010
- 2010-01-30 KR KR1020100008852A patent/KR20110089223A/ko not_active Application Discontinuation
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101329341B1 (ko) * | 2011-11-14 | 2013-11-15 | 대한민국 | 백일홍 추출물을 포함하는 소해면상뇌증의 예방 또는 치료용 조성물 |
WO2014025202A1 (ko) * | 2012-08-07 | 2014-02-13 | 씨제이제일제당(주) | 작약, 건강 혼합추출물을 포함하는 치매 및 인지기능장애 예방 또는 치료용 약제학적 조성물 |
KR20170015758A (ko) * | 2015-07-31 | 2017-02-09 | 한국식품연구원 | Schizosaccaromyces pombe를 이용한 생강 발효물 및 이의 용도 |
CN107300593A (zh) * | 2017-07-06 | 2017-10-27 | 成都市中草药研究所(成都市卫生计生药械科技服务中心) | 生姜及其炮制品中姜辣素成分的检测方法 |
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