KR20090131364A - Implantable drug release apparatus and drug delivery control system using the same - Google Patents

Abstract

PURPOSE: An internal embedded type drug-injecting apparatus and a drug-injection control system using the same are provided to inject the drug in the long term by charging the power supply with a non-contact type charging manner. CONSTITUTION: The internal embedded type drug-injecting apparatus includes: a case(100) formed with a seating groove in the upper surface; a drug storage module(200), inserted and fixed in the seating groove of the case, for storing the specific drug; a drug-injecting valve(300), combined through one side of the drug storage module and the case and opened and closed according to the specific control signal, for injecting the specific drug stored in the drug storage module to internal of human body; and an injection control module(400) for outputting the specific control signal to operate a drug release valve, since the operating control signal is wirelessly received from the exterior control apparatus.

Description

Injectable drug release device and drug release control system using same {IMPLANTABLE DRUG RELEASE APPARATUS AND DRUG DELIVERY CONTROL SYSTEM USING THE SAME}

The present invention relates to an intracorporeal drug release device and a drug release control system using the same, and more particularly, to be safely and easily inserted into the human body and to repeatedly refill specific drugs to perform long-term drug release. In addition, the present invention relates to an injectable drug release device and a drug release control system using the same, which can be used for a long period of time by charging a power supply with a non-contact charging method.

In general, in the treatment of patients with certain diseases (e.g. diabetes, cancer, hypertension, etc.) or metabolic (e.g. hormones) deficiency, the patient or guardian may take specific drugs (e.g. insulin, growth hormone, etc.) daily. Alternatively, the patient will be injected or administered 2-3 times a day.

In this case, the amount of a specific drug required by the patient is different depending on various effects such as the patient's condition and environment. In the case of insulin, for example, if a meal is made in excess of the usual amount, the drug should be administered in excess of the usual dose.

In addition, in the case of antihypertensive drugs, if the blood pressure rises above a certain level through monitoring the blood pressure according to the change of the surrounding environment, the administration of an antihypertensive agent for induction to normal blood pressure is required. Growth hormones are also typical drugs that need to be administered daily.

However, the conventional manual injection method was not always able to supply the patient with an exact reference amount of a specific drug, there was a inconvenience to go to the hospital to administer a larger amount of the specific drug than usual.

To improve this, an automatic insulin drug injector (commonly called an "insulin pump") is inserted into the body fat layer of the abdomen and the piston is driven to automatically inject the prescribed amount of insulin at a fixed time. It has been proposed in Korean Patent No. 290253.

However, conventional insulin autoinjectors, i.e., devices for releasing certain drugs, must be worn at all times with a drive mounted to the outer part of the human body with the needle inserted into the body, which is cumbersome when moving or acting. But there is a problem that the needle can be easily pulled out.

U.S. Patent No. 5,455,455 (Implantable drug delivery pump) has proposed a drug delivery system configured to enable the sensing of diabetes and infusion of glucose, insulin, etc., but it is difficult to use because it is impossible to refill the drug in the inserted state. .

In addition, US Patent No. 2007-0255233 (Implantable therapeutic substance delivery system with catheter access port control and method of use) is a refillable implantable active drug delivery system, a device of the method of directly connecting to the blood vessel to administer the drug Although disclosed, there is a disadvantage that control of release through immediate monitoring of patient condition cannot be achieved.

Accordingly, the present inventors have come to the present invention after research efforts to solve the above problems.

It is an object of the present invention to insert safely and simply into the human body, it is possible to repeatedly refill (refill) of a specific drug to perform a long-term drug release, as well as to use a long-term use by charging the power supply in a non-contact charging method An implantable drug release device is provided.

Another object of the present invention is to control the operation of the drug release device inserted into the body through a portable external control device by a wireless communication, by using the injectable drug release device that can perform the drug release more accurately and quickly To provide a drug release control system.

In order to achieve the above object, the first aspect of the present invention, the device is inserted into the body for releasing a specific drug, the seating groove is formed on the upper surface, the case forming a whole body; A drug storage module inserted into a seating groove of the case and storing the specific drug; A drug release valve inserted into and coupled to one side of the case and the drug storage module and opened and closed according to a specific control signal to release the specific drug stored in the drug storage module into the body; An emission control module installed in the case and wirelessly receiving an operation control signal from an external control device and outputting a specific control signal for operating the drug release valve; And a power supply module for supplying power for operating the drug release valve and the release control module.

Here, the case is preferably made of a polymer material.

Preferably, the polymer material is polymethyl methacrylate (PMMA), polydimethylsiloxane (PDMS), polyethylene, polypropylene, polyamide, polyester, polyvinyl chloride, polyvinylidene chloride, polyurethane , Polystyrene, ethylene-vinyl acetate copolymer may be any one selected from medical grade ABS (ABSi) resin (Acrylonitrile-Butadiene-Styrene Resin).

In addition, the case may be made of a bioceramic (eg, alumina, etc.) in addition to the polymer material, if necessary, may be configured by coating a biocompatible polymer material on a metal.

Preferably, the drug storage module is made of a housing formed with a space for storing the specific drug, one surface of the housing in contact with the skin may be made of a self-healing polymer material or silicone rubber. .

Preferably, the drug release valve, by using the ion conductive polymer film (ICPF) to release the specific drug into the body by the shape change according to a specific driving voltage and to prevent the introduction of body fluids. Can be configured.

Preferably, the drug release valve may be configured to allow the specific drug to be released into the body in a piezoelectric drive method using a piezoelectric element (eg, PZT, etc.).

Preferably, the drug release valve is installed in the inside of the at least one ion conductive polymer film (ICPF) using the pressure of the volume change in the chamber by the shape change according to a specific driving voltage to release the specific drug. It may further include a micro pump module for controlling.

Preferably, a porous nozzle module fixedly coupled to the outlet side end of the drug release valve, the support body so that a specific drug released from the outlet side can be smoothly released into the body may be further included.

Preferably, the porous nozzle module is configured to be radially coupled to a plurality of support plates arranged in a plurality of cylindrical support members spaced apart at a predetermined interval in a row, the support plate is formed with a plurality of through holes between each support member The specific drug may be diffused and released through the empty space between the support members.

Preferably, a built-in installation in the case, and electrically connected to the release control module is further included a supercapacitor for discharging the stored energy instantaneously when more than necessary voltage or power is required for the release of the specific drug Can be.

Preferably, the power supply module is composed of at least one battery, it may be configured to enable the charging of the battery in a non-contact charging method using an external magnetic or electric field.

A second aspect of the present invention provides an injectable drug release device for inserting into a body to release a specific drug; And a portable external controller provided to be portable by the user and wirelessly communicating with the drug release device to output an operation control signal for controlling the operation of the drug release device according to a predetermined release control command of the specific drug. The present invention provides a drug release control system using an injectable drug release device.

Here, the drug release device, the seating groove is formed on the upper surface, the case forming a whole body; A drug storage module inserted into a seating groove of the case and storing the specific drug; A drug release valve inserted into and coupled to one side of the case and the drug storage module and opened and closed according to a specific control signal to release the specific drug stored in the drug storage module into the body; An emission control module installed in the case and receiving an operation control signal from the external control device and outputting a specific control signal for operating the drug release valve; And a power supply module for supplying power for operating the drug release valve and the release control module.

Preferably, the terminal may further include a specific medical institution terminal for managing to set the release control command of the specific drug to the external control device through wired / wireless communication according to the user's disease information.

Preferably, the drug release device may perform the drug release operation by the operation control signal output from the external control device, and as a result, the information data can be controlled to be transmitted to a specific medical institution terminal through the external control device. .

Preferably, the external control device may control to transmit an error message to the specific medical institution terminal when the result information data transmitted from the drug release device is not answered.

Preferably, the external control device may further include a drug release button to manually output the release control command of the specific drug when the emergency occurs.

Preferably, the drug release device completes the drug release operation by the operation control signal output through the drug release button of the external control device, and as a result transmits the information data to a specific medical institution terminal through the external control device The external control device may control an error message and current location information data to be transmitted to the specific medical institution terminal when the result information data transmitted from the drug release device is not answered.

Preferably, communication between the drug release device and the external control device may be performed using Bluetooth communication.

Preferably, the communication between the drug release device and the external control device may be made by transmitting and receiving data in and out of the body using the human body as a medium.

According to the injectable drug release device and the drug release control system using the same according to the present invention as described above, it can be safely and simply inserted into the human body, it is possible to repeatedly refill (refill) of a specific drug for long-term drug release Not only can it be performed, there is an advantage that can be used for a long time by charging the power supply in a non-contact charging method.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. However, embodiments of the present invention illustrated below may be modified in many different forms, and the scope of the present invention is not limited to the embodiments described below. The embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

Figure 1 is a combined perspective view for explaining the injectable drug release device according to an embodiment of the present invention, Figure 2 is an exploded perspective view for explaining the injectable drug release device according to an embodiment of the present invention, Figure 3a 3B is a conceptual view for explaining the structure and operation principle of the drug release valve applied to an embodiment of the present invention.

1 to 3, the drug release device (Drug Release Apparatus, DRA) according to an embodiment of the present invention is inserted into the body to release a specific drug, largely the case 100, drugs It comprises a storage module 200, drug release valve 300, the release control module 400 and the power supply module 500.

Here, the case (100) is, for example, forming a whole body in a flat round plate shape, the upper surface is formed with a seating groove 110 of a predetermined depth, the drug release valve 300 on one side At least one through hole 120a and 120b for insertion coupling is formed.

Since the case 100 is in direct contact with the body, it is preferable that the case 100 is manufactured in a three-dimensional shape using a polymer material approved by the Food and Drug Administration (FDA).

In this case, the polymer material may be, for example, polymethyl methacrylate (PMMA) or polydimethylsiloxane (PDMS), and the like, but is not limited thereto. For example, conventional polymer materials such as polyethylene and polypropylene may be used. , Polyamide, polyester, polyvinyl chloride, polyvinylidene chloride, polyurethane, polystyrene, ethylene-vinyl acetate copolymer medical grade ABS (ABSi) resin (Acrylonitrile-Butadiene-Styrene Resin) It may be.

In addition, the case 100 may be made of bioceramic (eg, alumina, etc.) in addition to the polymer material as needed. For example, when the case 100 is made of metal or nonferrous metals such as aluminium and iron, the polymer may be used. It may also be constructed by coating a material or biocompatible polymer material.

The drug storage module 200 is inserted and seated in the seating groove 110 of the case 100, and performs a function of storing a specific drug, such that a space 210 for storing the specific drug is formed therein. It is made of a fixed coupling of the housing 220 and the cover 230.

Here, at least one through hole 225a and 225b is formed at one side of the housing 220 to insert and couple the inlet side of the drug release valve 300 to discharge the specific drug stored in the space 210 to the outside. It is.

The cover portion 230 is in direct contact with the inside of the skin to replenish the specific drug, and when replenishing the specific drug is injected using a conventional syringe or the like, and restored to its original shape at the moment of removing the syringe The specific drug is preferably formed of a self healing polymer material so as not to flow to the outside, but is not limited thereto. For example, the specific drug may be formed of medical rubber (such as a ringer solution cap) or silicone rubber.

At this time, the self-healing polymer material is typically applied to the chemical structure of the existing rubber to increase to several times the original size to return to the original size, even after the breakage using fatty acids and urea pressed a few parts at room temperature It is a substance that returns to its original form within minutes.

In other words, by combining the ditopic molecules that bind two other molecules and the tritopic molecules that bind three other molecules with hydrogen linkage with weaker binding force, At its core, the hydrogen ring breaks when the rubber breaks, but acts as an adhesive.

These materials, in which small molecules of different properties are mixed, have a transparent plastic-like property at about 8 ° C and stretch up to about five times their original size like rubber. However, these self-healing polymeric materials can be recombined and reused at room temperature of about 20 ° C. without the need for heating or high pressure due to the movement of molecules to recombine with their original partners even if broken.

The drug release valve 300 is inserted into and coupled to the through holes 120a and 120b and 225a and 225b formed in the housing 220 of the case 100 and the drug storage module 200, and is output from the emission control module 400. The inlet and / or outlet side is opened and closed according to the specific control signal, thereby releasing the specific drug stored in the space 210 of the drug storage module 200 into the body.

The drug release valve 300, for example, by using an ion conductive polymer film (ICPF) to allow the specific drug to be released into the body by the shape change according to a specific driving voltage and the body fluid drug It is preferably configured to prevent entry into the discharge device (DRA).

That is, as shown in Figure 3a, Figure 3a (a) and (b) is a conceptual diagram showing the structure and operation principle, respectively, the metal electrode layer (Metal Electrode) provided on both sides of the ion conductive polymer film (ICPF) Due to the driving voltage (V _d ) applied between the layers (M), the positive charges (Na + ions or Li + ions in which the H + ions of the sulfonic acid group are substituted through the ion exchange process) are moved toward the cathode. Accordingly, the bending of the ICPF actuator A occurs as a result of the increase in the density of the negative electrode side and the reduced density of the positive electrode side by water molecules moving toward the negative electrode.

And, as shown in Figure 3b, Figure 3b (a) and (b) is a view showing the forward and reverse state of the specific drug flow, respectively, the inlet and / or outlet side of the drug discharge valve 300 By installing the ICPF actuator A shown in FIG. 3A described above at the end E and applying a driving voltage to bend toward the exit side when the specific drug is released, the backflow of the specific drug can be effectively prevented.

On the other hand, the drug release valve 300 applied in one embodiment of the present invention is implemented using the ion conductive polymer film (ICPF) so that the specific drug can be released into the body by the shape change according to a specific driving voltage, Without being limited, the drug release valve 300 may be a piezoelectric drive method using a piezoelectric element such as PZT (Plumbum-Zirconate-Titanate) or the like so that the specific drug can be smoothly released into the body, that is, ferroelectric. A piezo-actuator having a thin film formed thereon and an electrode attached to the top and the bottom thereof may be provided to convert the mechanical energy into the electrical energy.

In addition, Figures 4a to 4c is a cross-sectional view for explaining conceptually the structure and operation principle of the micro pump module provided in the drug release valve of Figure 3, separated and combined perspective view, inside or outside the drug release valve 300 Micro pump module 350 for controlling the release of the specific drug may be further included.

The micro pump module 350 uses at least one ion conductive polymer film (ICPF) to release the specific drug through the pressure due to the volume change in the chamber (C) due to the shape deformation according to the specific driving voltage. It performs the function of controlling.

That is, the micro pump module 350 includes at least one ICPF actuator A and a support plate SP based on a base plate BP so that a plurality of chambers C are formed therein. By sequentially stacking to form a membrane (Membrane), it is possible to effectively control the release of the specific drug according to the pressure according to the volume change in the chamber (C) by the deformation of the ICPF actuator (A).

Furthermore, FIGS. 5A and 5B are enlarged perspective views and front views of the porous nozzle module of FIGS. 1 and 2, and are fixedly coupled to an outlet end of the drug release valve 300, and an outlet side of the drug release valve 300. A porous nozzle module 600 in the form of a scaffold may be further included to smoothly release a specific drug released from the body.

The porous nozzle module 600 is located on the outer side of the drug release valve 300 to perform the function of suppressing the antigen / antibody reaction of the human body when the specific drug is released, a plurality of cylindrical support members 610 Is radially coupled to a plurality of support plates 620 arranged to be spaced apart at regular intervals in a row.

In addition, the support plate 620 is, for example, in the form of a honeycomb, and a plurality of through holes 625 are formed between the respective support members 610, so that a specific drug is diffused and released through the empty space between the support members 610. Can be.

On the other hand, the support member 610 applied to an embodiment of the present invention is formed in a cylindrical shape, but is not limited to this, for example, may be formed in various forms such as a triangular prism, a square pillar or a polygonal pillar.

Release control module 400 is responsible for the overall control of the device, installed in the case 100, that is, installed between the seating groove 110 and the drug storage module 200 of the case 100, the external control device 6 (see FIG. 6, 800) wirelessly receives the operation control signal to perform a function for outputting a specific control signal for periodically operating the drug release valve 300 every predetermined time.

On the other hand, as shown in Figure 2, the reference numeral 350 is a communication module (Communication Module) is electrically connected to the emission control module 400, and the external control device 700, for example, such as Bluetooth (Bluetooth) To transmit / receive via communication. In an embodiment of the present invention, the communication module 350 is provided separately, but is not limited thereto, and may be implemented to be included in the emission control module 400.

In addition, the power supply module 500 is installed in the case 100 and performs a function of supplying power for operating the drug release valve 300 and the release control module 400.

The power supply module 500 is composed of at least one battery (B), it may be configured to enable the charging of the battery (B) in a non-contact charging method using an external magnetic or electric field.

In this case, the non-contact charging method is, for example, the 'wire tree city (Wire tree) that transmits the power wirelessly by using a resonance phenomenon in which the electric charger and the electric wave conversion mechanism of the electric product vibrate at the same frequency to form an electric field and a magnetic field. WiTricity 'technology.

In addition, when a current flows through a coil in which a copper wire is wound, a coil becomes a magnet. On the contrary, when a magnet moves in a coil, a splash pad is used. It can also be implemented as a system.

In other words, when a current flows in the splash pad, a magnetic field is generated in the internal coil, and the coil of the pad becomes a magnet to induce a current in another coil in an electronic product such as a mobile phone to charge a battery.

In addition, it is installed in the case 100, and is electrically connected to the release control module 400, if more than the voltage or power required for the release of the specific drug, the super energy to discharge the stored energy instantaneously A capacitor (Supper Capacitor) 700 may be further included.

The supercapacitor 700 may maintain the shape of the drug release device according to an embodiment of the present invention by being installed surrounded by the inner peripheral surface of the seating groove 110 of the case 100. Meanwhile, the supercapacitor 700 is separately provided, but is not limited thereto, and may be integrally included in the emission control module 400.

Intracorporeal drug release device (DRA) according to an embodiment of the present invention configured as described above is preferably inserted into the lower part of the clavicle, for example, on the left chest or right chest, the insertion depth is about 1 cm below the skin It is preferred to be inserted into.

Figure 6 is a block diagram illustrating the overall drug release control system using the in-insertable drug release device according to an embodiment of the present invention.

Referring to FIG. 6, a drug release control system according to an embodiment of the present invention includes an intracorporeal drug release device (Drug Release Apparatus, DRA), an external control device 800, and a specific medical institution terminal 900. do.

Herein, the intracorporeal drug release device (DRA) is inserted into the body to release a specific drug, which will be described in detail with reference to FIGS. 1 to 5.

The release control module 400 of the drug release device (DRA) completes the drug release operation by the operation control signal output from the external control device 800, and as a result, the information control the external control device 800 It can be controlled to be transmitted to the specific medical institution terminal 900 through.

The external control device 800 is provided to be portable by the user, and wirelessly communicates with the drug release device (DRA) (eg, Bluetooth, etc.) according to a predetermined release control command of the drug release device (DRA). Outputs an operation control signal for controlling the operation of the "

On the other hand, communication between the drug release device (DRA) and the external control device 800 is preferably made by using, for example, Bluetooth (Bluetooth) communication, but is not limited thereto, and transmits and receives data in and out of the body using the human body as a medium. That is, communication through the E-field propagation method may be applied.

The external control device 800 controls to wirelessly transmit an error message to the specific medical institution terminal 900 or the specific manager's mobile phone H when the result information data transmitted from the drug release device (DRA) is not answered at least once. can do.

In addition, the external control device 800 may further include a drug release button 850 to manually output the release control command of the specific drug when an emergency occurs.

After the drug release device (DRA) completes the drug release operation by the operation control signal output through the drug release button 850, the result information data through the external control device 800 specific medical institution terminal 900 Can be controlled.

At this time, the external control device 800 specifies the current position information data using an error message and a conventional GPS (Global Positioning System) method when the result information data transmitted from the drug release device (DRA) is not answered at least one or more times. The medical institution terminal 900 may be controlled to be transmitted to the mobile phone H of a specific manager.

That is, the external control device 800 is equipped with a GPS receiver to receive the location information transmitted from the GPS satellites through the GPS antenna to generate the current location information, and through this mobile carrier (not shown) a specific medical institution terminal 900 ) Can be sent.

In addition, the specific medical institution terminal 900 performs a function of managing to set the release control command of the specific drug to the external control device 800 through wired / wireless communication according to the user's disease name.

Although a preferred embodiment of the in-vitro drug release device and a drug release control system using the same according to the present invention has been described above, the present invention is not limited thereto, but the claims and the detailed description of the invention and the scope of the accompanying drawings. Various modifications can be made therein and this also belongs to the present invention.

1 is a perspective view of the combination for explaining the injectable drug release device according to an embodiment of the present invention.

Figure 2 is an exploded perspective view for explaining the injectable drug release device according to an embodiment of the present invention.

3a and 3b is a conceptual diagram for explaining the structure and operation principle of the drug release valve applied to an embodiment of the present invention.

4A to 4C are cross-sectional views, separations, and coupling perspective views illustrating the structure and operation principle of the micropump module provided in the drug release valve of FIG. 3.

5A and 5B are enlarged perspective views and front views of the porous nozzle module of FIGS. 1 and 2.

Figure 6 is a block diagram illustrating the overall drug release control system using the in-insertable drug release device according to an embodiment of the present invention.

Claims (21)

A device for insertion into a body to release a particular drug, Seating groove is formed on the upper surface, the case forming the overall body; A drug storage module inserted into a seating groove of the case and storing the specific drug; A drug release valve inserted into and coupled to one side of the case and the drug storage module and opened and closed according to a specific control signal to release the specific drug stored in the drug storage module into the body; An emission control module installed in the case and wirelessly receiving an operation control signal from an external control device and outputting a specific control signal for operating the drug release valve; And Injectable drug release device comprising a power supply module for supplying power for operating the drug release valve and the release control module. According to claim 1, The case is an injectable drug release device, characterized in that made of a polymeric material. According to claim 1, The case is an injectable drug release device, characterized in that the metal or non-ferrous metals are coated with a polymeric material. The method according to claim 2 or 3, The polymer material is polymethylmethacrylate (PMMA), polydimethylsiloxane (PDMS), polyethylene, polypropylene, polyamide, polyester, polyvinyl chloride, polyvinylidene chloride, polyurethane, polystyrene Or ethylene-vinyl acetate copolymer medical grade ABS (ABSi) resin (Acrylonitrile-Butadiene-Styrene Resin) is any one selected from the injectable drug release device. According to claim 1, The drug storage module, It is made of a housing formed with a space portion for storing the specific drug, one surface of the housing in contact with the inner skin is self-healing (Self Healing) characterized in that made of a polymeric material or silicone rubber. According to claim 1, The drug release valve, Injectable drug, characterized in that the specific drug is released into the body by the shape deformation according to a specific driving voltage using an ion conductive polymer film (ICPF) and to prevent the introduction of body fluids Ejection device. According to claim 1, The drug release valve, Injectable drug release device, characterized in that the specific drug is configured to be released into the body by a piezoelectric drive method using a piezoelectric element. According to claim 1, The microcontroller is installed inside the drug release valve and controls the release of the specific drug through the pressure according to the volume change in the chamber due to the shape deformation according to the specific driving voltage using at least one ion conductive polymer film (ICPF). Intracorporeal drug release device, characterized in that further comprises a pump module. According to claim 1, Is inserted into the distal end of the drug release valve, the injectable drug release device further comprises a porous nozzle module in the form of a support so that the specific drug released from the outlet side is smoothly released into the body. The method of claim 9, The porous nozzle module is composed of a plurality of cylindrical support members radially coupled to a plurality of support plates arranged in a line at a predetermined interval, The support plate has a plurality of through-holes are formed between each support member, the injectable drug release device, characterized in that the specific drug is diffused and released through the empty space between the support member. According to claim 1, It is installed in the case, and is electrically connected to the release control module, when the discharge of the specific drug when a voltage or power is required, the supercapacitor is further included to discharge the stored energy momentarily Injectable drug release device characterized in that. According to claim 1, The power supply module is composed of at least one battery, the implantable drug release device, characterized in that configured to enable the charging of the battery in a non-contact charging method using an external magnetic or electric field. An injectable drug-release device inserted into the body to release a specific drug; And It is provided to be portable to the user, the body including a portable external control device for wirelessly communicating with the drug release device for outputting an operation control signal for controlling the operation of the drug release device in accordance with a predetermined release control command of the specific drug Drug release control system using an implantable drug release device. The method of claim 13, The drug release device, Seating groove is formed on the upper surface, the case forming the overall body; A drug storage module inserted into a seating groove of the case and storing the specific drug; A drug release valve inserted into and coupled to one side of the case and the drug storage module and opened and closed according to a specific control signal to release the specific drug stored in the drug storage module into the body; An emission control module installed in the case and receiving an operation control signal from the external control device and outputting a specific control signal for operating the drug release valve; And And a power supply module for supplying power for operating the drug release valve and the release control module. The method of claim 13, According to the disease name of the user through the wire / wireless communication through a specific medical institution terminal for managing to set the control command of the release of the specific drug to the external control device further comprises a drug release using the injectable drug release device, characterized in that Control system. The method of claim 13, The drug release device completes the drug release operation by the operation control signal output from the external control device, and as a result the information data is controlled to be transmitted to a specific medical institution terminal through the external control device Drug release control system using an implantable drug release device. The method of claim 16, The external control device is a drug release control system using an injectable drug release device, characterized in that to control the transmission of the error message to the specific medical institution terminal when the response information of the result information transmitted from the drug release device. The method of claim 13, The external control device is a drug release control system using an injectable drug release device, characterized in that the drug release button further comprises a user to manually output the release control command of the specific drug when an emergency occurs. The method of claim 18, The drug release device completes the drug release operation by the operation control signal output through the drug release button of the external control device, and as a result to control the information data to be transmitted to a specific medical institution terminal through the external control device , The external control device controls the drug release using the injectable drug release device, characterized in that the error message and the current location information data is transmitted to the specific medical institution terminal when the response information transmitted from the drug release device is not answered. system. The method of claim 13, Communication between the drug release device and the external control device is a drug release control system using an injectable drug release device, characterized in that made using Bluetooth (Bluetooth) communication. The method of claim 13, Communication between the drug release device and the external control device is a drug release control system using an in-vivo type drug release device, characterized in that made in the manner of transmitting and receiving data in and out of the body using the human body as a medium.

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