KR20030055457A - Aerosol for helping quit smoking - Google Patents

Abstract

The present invention relates to an aerosol spraying into the oral cavity and respiratory tract as a smoking cessation aid to reduce the need for smoking. The aerosol of the present invention is a composition comprising a food-derived acid, citric acid, tartaric acid, and vitamin C (ascorbic acid) and adipic acid as a main component. Consists of the principle of reducing the need for smoking through the induction of sensations similar to those felt in the respiratory tract by smoking and anesthesia of the temporary respiratory tract.

Description

Aerosol for helping quit smoking

The present invention relates to an aerosol that reduces the desire to smoke by spraying in the mouth and respiratory tract as a smoking cessation aid. The aerosol of the present invention contains a solution in which food-derived acid is dissolved in an inert solvent as a main component, and particularly preferably citric acid, tartaric acid and vitamin C and ascorbic acid. It consists of a composition of a mixture of adipic acid (adipic acid) in a ratio, it is a product that uses the principle of reducing the desire to smoke through the induction of a similar sense to the respiratory tract by smoking and anesthesia of the temporary respiratory tract.

Recently, many researches on the harmfulness of tobacco have been reported, and social interest in smoking cessation has increased considerably. In addition, a variety of programs and products have been developed to reduce the smoking rate, along with awareness of the harmful effects of smoking. To date, smoking cessation aids have been developed in the form of patches and gum as a way to reduce withdrawal by injecting nicotine through the skin or oral cavity. However, nicotine injection and the excessive dose of nicotine itself cause side effects such as dizziness, increased heart rate, sleep disorders, headache, nausea, vomiting, muscle pain, and muscle stiffness. In addition, direct contact causes damage, such as skin rashes in the case of patches, unpleasant taste and damage to teeth and gums in the case of gum. Therefore, in order to prevent such side effects and increase the success rate of smoking cessation, there is an urgent need to develop a nicotine-free smoking cessation aid.

Tobacco smoke is estimated at 100,000 chemicals, including 4,000 known substances. These chemicals in tobacco smoke cause the peculiar taste, smell, and bronchial irritation produced by smoking. Particles of these chemicals, especially tar, preferentially cause respiratory irritation, not the nervous system. The respiratory location stimulated by smoking is the trachea area just below the larynx. This area is 2 cm below the narrow opening of the larynx, which redirects the particles entering the trachea. These nicotine and chemical particles contained in cigarette smoke leave behind a harness and brand-specific sensation in the smoker's specific respiratory tract. In particular, smoking of cigarettes containing high amounts of tar and nicotine has a higher level of stimulation at specific respiratory tracts than cigarettes containing low tar and nicotine, resulting in much higher satisfaction and less desire to smoke. . In addition, studies using aerosol containing lidocain, a local anesthetic, confirmed that the desire for smoking is reduced when anesthesia is applied to the respiratory tract of a specific area. This suggests that the above-mentioned stimulation of a specific part of the respiratory tract is related to smoking desire and satisfaction.

Therefore, an object of the present invention is to provide a smoking cessation aid that improves the harmfulness of conventional drugs for smoking cessation, as well as is easy to use and has an effect of reducing the need to quit smoking.

1 is a graph comparing the stimulation intensity for the respiratory tract after inhalation for four test substances.

2 is a graph comparing smoking desire after inhalation with respect to four test substances.

In order to achieve the above object, the present inventors came to the present invention while experimenting with anesthesia effects on the respiratory tract on various harmless components of the human body. Anti-smoking aid of the present invention is a food-based acidic substance citric acid (citric acid), tartaric acid (tartaric acid), vitamin C (ascorbic acid), adipic acid (adipic acid) containing at least one aerosol containing a desire to smoke It can help people who want to quit smoking by spraying it into their mouth when they feel it and feeling similar to the stimulation caused by smoking through stimulation of a specific part of the respiratory tract, and also causing temporary anesthesia in the respiratory tract.

Acidic materials used in the present invention are derived from food and are harmless to the human body. In particular, N. K Burki et al., "The effects of added inspiratory load for assessing the degree of airway anethesia on magnitude estmation of added inspiratory resistive and elastic load" (the American Review of Respiratory Diseases, 127, 2-4, 1983 ) Reported no coughing by oral injection of citric acid. It was confirmed that injection of appropriate concentration of citric acid induces anesthesia in a part of the respiratory tract.

The present invention was developed to spray in a spray in the form of a liquid aerosol. The aerosol spray of the present invention is inhaled into the oral cavity and respiratory tract and causes irritation similar to the stimulation caused by tar, including nicotine in tobacco smoke. Appropriate food-derived acidic substances have been included in the aerosols for this purpose to cause similar stimuli to smoking.

The present invention relates to an anti-smoking auxiliary aerosol containing 5 to 30% by weight of food-derived acidic substances.

In addition, the present invention is characterized in that at least one selected from the group consisting of citric acid (citric acid), tartaric acid (tartaric acid), vitamin C (ascorbic acid) and adipic acid (adipic acid) as the food-derived acidic substance. It relates to an anti-smoking auxiliary aerosol.

In addition, the present invention relates to a non-smoking auxiliary aerosol characterized in that it contains 10-15% by weight citric acid, 3-5% by weight tartaric acid, 5-10% by weight vitamin C, 3-5% by weight adipic acid.

Furthermore, the present invention relates to an anti-smoking auxiliary aerosol, characterized in that one of water, propylene glycol and ethanol is selected as the solvent of the solution.

The food-derived acidic substance which is the main ingredient of the non-smoking auxiliary aerosol of the present invention is not particularly limited as long as it is harmless to the human body. acid, etc., is derived from food, and is harmless to the human body unless an excessively large amount is ingested.

Each food-derived acidic substance was mixed to about 5-15% of the weight of the liquid solvent to form an aerosol spray. However, each amount varies depending on the degree of mixing and the overall effect of the acidic substances mentioned above. The food-derived acidic substance is preferably 5 to 30% by weight based on the weight of the aerosol solution. In case of less than 5% by weight, the respiratory tract irritation intensity and anesthesia effect is insignificant, and there is little effect as a smoking cessation aid, and in the case of more than 30% by weight, the increase in stimulation intensity and smoking cessation inhibitory effect on the increase of acidic substance is insignificant.

Liquid solvents that carry acidic substances to the oral cavity and respiratory tract can be stored in an aerosol container and can be used as long as they do not react with the acidic substance. More preferred examples include water, propylene glycol, ethanol and the like.

Hereinafter, the configuration of the present invention through a specific embodiment. However, the scope of the present invention is not limited only to the scope of the following examples.

Example

The aerosol solution was formulated to be food-derived acidic material, 15% citric acid, 5% tartaric acid, 5% vitamin C, 5% adipic acid, based on the weight of the solvent, water. The mixed solution was placed in the sprayer of a small container. Spraying consists of fine mist particles. The injector used a container having a length of 5-15 cm and a diameter of 1-2 cm and a control cap to spray the contents of the container by pressure. The aerosol vessel containing citric acid and the aforementioned acid was compressed using an appropriate pressure using an inert gas such as freon.

Citric acid aerosol solution of the injector was tested for 20 smokers to test the effect of the present invention. Subjects consisted of an average of one pack of cigarettes a day. The test subjects tested the effects of the present invention after inhaling the following substances: (1) Anti-smoking auxiliary aerosol of the present invention consisting of a mixed solution of four food-derived acidic substances.

(2) air

(3) low nicotine and low tar, commercialized tobacco (expo: brand)

(4) Tobacco used by smokers.

Each subject randomly inhaled the above material four times. For the experiment, cigarette smoke was collected in a volume of 30 square meters using a syringe and suction was made through a Teflon tube. In order to more accurately analyze the respiratory tract irritation felt in each experiment, the mouth was paralyzed with 2% lidocaine, a local anesthetic, and the nasal cavity was blocked with a cotton plug.

The evaluation of the experiment was measured by measuring the intensity of inhalation of each substance and the desire for smoking after inhalation to a size of 10 points. Experimental results are shown in the graphs of FIGS. 1 and 2.

FIG. 1 compares the intensity of each substance in the respiratory system after inhalation with the intensity of stimulation with the tobacco smoked by the test subjects. As shown in the graph, the citric acid aerosol of the present invention has a higher stimulation intensity than simply inhaling air and inhaling low-tar-low nicotine cigarettes, and is similar to the degree of stimulation intensity of cigarettes used by subjects.

Figure 2 measures the degree of desire for smoking after inhalation of each of the test substances (1) to (4) 10 times. Although aerosols from food-derived acidic substances have a greater desire than cigarettes used by subjects, they have been found to reduce smoking desires than air and low tar-low nicotine cigarettes. This explains that the smoking desire can be effectively reduced by spraying the aerosol of the present invention into the respiratory tract during the smoking desire.

As discussed above, the smoking cessation aerosol of the present invention does not contain nicotine and does not cause side effects caused by conventional smoking cessation aids.

In addition, the smoking cessation aid aerosol of the present invention has a food-based acidic substance as a main component has almost no adverse effect on the human body.

In addition, the smoking cessation aid aerosol of the present invention has a strong irritation intensity to the respiratory tract after inhalation can significantly reduce the desire to smoke.

Claims (4)

Non-smoking supplemental aerosol containing 5-30% by weight of food-derived acid According to claim 1, wherein the food-derived acid is selected from the group consisting of citric acid (citric acid), tartaric acid (tartaric acid), vitamin C (ascorbic acid) and adipic acid (adipic acid). Assisted smoking cessation aerosol. The non-smoking auxiliary aerosol according to claim 2, which contains 10-15 wt% citric acid, 3-5 wt% tartaric acid, 5-10 wt% vitamin C, and 3-5 wt% adipic acid. The non-smoking auxiliary aerosol according to any one of claims 1 to 3, wherein the solvent of the solution is one of water, propylene glycol and ethanol.