KR20020063895A - Personal care articles comprising cationic polymer coacervate compositions - Google Patents

Abstract

The present invention relates to a substantially dry, disposable personal care article containing the following (a) and (b):

(a) a water-insoluble substrate comprising a nonwoven layer; And

(b) a therapeutic efficacy member disposed adjacent said water-insoluble substrate,

Said member comprising from about 10% to about 100% by weight of said water insoluble substrate of a therapeutically efficacious composition comprising (c) and (d) and forming a coacervate when said article is exposed to water ≪ / RTI > characterized in that:

(c) a safe effective amount of a cationic surfactant;

(d) a safe effective amount of anionic surfactant.

It has been found that the article is particularly useful for personal cleansing applications, i. E., Skin and hair. Accordingly, the present invention also relates to a method of cleansing and / or therapeutic treatment (e.g., conditioning) of skin and hair using the article of the present invention.

Description

[0001] PERSONAL CARE ARTICLES COMPRISING CATIONIC POLYMER COACERVATE COMPOSITIONS [0002] This invention relates to a personal care product comprising a cationic polymeric co-

Personal care products, particularly cleansing and conditioning products, have been marketed in many forms, such as conventional bar soaps, creams, lotions, and gels. Typically, these products have been tried to meet a number of criteria to be recognized by consumers. These criteria include cleansing effects, skin texture, mildness to the skin, hair and mucous membranes, and the volume of foam. An ideal personal cleanser should gently cleanse the skin or hair, cause little or no irritation, do not leave a lot of detergent buildup on the skin or hair after frequent use, or do not overdry the skin or hair.

It is also highly desirable to deliver such cleansing and conditioning efficacy using disposable products. Disposable products are convenient because they do not need to carry or store the cumbersome bottles, bars, pails, tubes and other forms of clutters that contain cleansing products and other products that can provide therapeutic or cosmetic benefits. In addition, the use of a disposable article, such as a sponge, washcloth, or widely-used cleansing tool, may result in undesirable characteristics due to bacterial growth, unpleasant odors, and other repeated use It is more hygienic.

The article of the invention is surprisingly simple, inexpensive, and provides effective cleansing and / or therapeutic efficacy to the skin and hair in a sanitary manner. The present invention provides simplicity that does not need to carry, store, or use a separate tool (e.g., a washcloth or sponge), a cleanser, and / or a therapeutic efficacy product. Such articles are easy to use since they are in the form of single disposable personal care articles or multiple disposable articles useful for cleansing as well as therapeutic efficacy or application of cosmetic preparations. The articles are also suitable for use in or with another personal care tool designed for wider use. In this case, the article of the invention is placed in or attached to a separate, non-disposable personal care tool, such as a bath towel or washcloth towel. The disposable article of the present invention can also be detachably attached to a handle or grip suitable for cleansing the article and / or moving it on a surface to be treated (e.g., conditioned).

In preferred embodiments, the article of the present invention is suitable for personal care applications, but may be used as cleansing and / or as a surface or area requiring application of efficacies such as waxes, conditioners, UV protectants, but also in various other industrial fields such as vehicle care, furniture care, animal care, and the like.

In a preferred embodiment of the present invention, the article is suitable for personal care applications and is useful for cleansing and / or conditioning skin, hair and similar keratinous surfaces requiring such treatment. Consumers wet these items with water and use them by rubbing on the area to be treated. The article consists of a water insoluble substrate and a therapeutic efficacy member. Without wishing to be bound by theory, it is believed that the nonwoven layer of the substrate enhances, in particular, cleansing and exfoliation, and optimizes the transport and deposition of therapeutic efficacy or cosmetic agents that may be contained within the article.

Summary of the Invention

The present invention is a substantially dry disposable personal care article comprising:

a) a water-insoluble substrate containing a nonwoven layer; And

b) a therapeutic efficacy member disposed adjacent said water-insoluble substrate,

Characterized in that it comprises from about 10% to about 1000% of the water insoluble substrate of a therapeutic efficacious composition comprising: 1) and 2) and forming a coacervate when the article is exposed to water article:

1) a safe effective amount of a cationic polymer;

2) Safe effective amount of anionic polymer.

The invention also relates to a method of cleansing and / or conditioning skin and hair, comprising a) wetting the article with water and b) contacting the skin or hair with the moistened article.

All percentages and ratios used herein are by weight unless otherwise indicated and all measurements are made at 25 ° C unless otherwise specified. The present invention may, and may be, constitute, or essentially consist of, the essential and optional components and components thereof.

In the description of the invention various embodiments and / or individual characteristics are disclosed. As will be apparent to those skilled in the art, any combination of the above embodiments and features is possible, and the preferred practice of the invention can be accomplished.

All documents referred to herein, including patents, patent applications, and published disclosures, are incorporated herein by reference in their entirety.

The present invention is directed to disposable personal care articles suitable for cleansing and / or therapeutically treating skin, hair, and any other area requiring cleansing and / or therapeutic treatment. Wherein the article comprises a water insoluble substrate comprising a nonwoven layer and a therapeutic benefit component disposed adjacent the water insoluble substrate wherein the member is water insoluble A therapeutically efficacious composition comprising a safe effective amount of a cationic polymer and a safe effective amount of an anionic surfactant, relative to the weight of the substrate, of from about 10% to about 1000%, said composition comprising , To form coacervate.

Consumers use the article by wetting it with water and rubbing the area to be treated (e.g., conditioned) to be cleansed and / or treated therapeutically.

The present invention also includes a method of cleansing and / or conditioning skin and hair using the article of the present invention.

As used herein, the term " disposable " means an article that is disposed or disposed of after a limited number of uses, preferably less than 25 times, more preferably less than about 10 times, and most preferably less than about 2 times total use , Is used in a general sense.

As used herein, the expression " substantially dry " means that the article of the present invention has a viscosity of less than about 0.95 gms, preferably less than about 0.75 gms, more preferably less than about 0.5 gms, even more preferably less than about 0.25 gms More preferably less than about 0.15 gms, and most preferably less than about 0.1 gms. Measurement of moisture retention is discussed later.

The personal care article of the present invention contains the following essential ingredients.

Water-insoluble substrate

The article of the present invention comprises a water-insoluble substrate comprising at least one nonwoven layer or ply. Preferably, the nonwoven layer is non-scouring. As used herein, " non-abrasive " means that the layer has a thickness of greater than about 15, preferably greater than about 30, more preferably greater than about 50, even more preferably greater than about 70, Means the wear value measured by the wear value methodology. Preferably, the substrate layer is refreshing but tender to the skin of the consumer at the time of use.

Without being bound by theory, the water-insoluble substrate enhances cleansing and therapeutic treatment. The substrate may have the same or different texture on each side so that the gripping side of the article is the same or different texture to the skin / site interface. The substrate can serve as an efficient foaming and exfoliating tool. By being in physical contact with the skin or hair, the substrate significantly aids in cleansing and removing dust, makeup, dead skin, and other residues. However, in a preferred embodiment, the substrate is nonabrasive or nonabrasive to the skin.

Suitable materials for the nonwoven layer are selected from the group consisting of cellulosic nonwoven, sponges (i.e. both natural and synthetic), formed films, batting, and combinations thereof. Advantageously, said layer comprises a layer of at least one material selected from the group consisting of a cellulosic nonwoven, a molded film, a lofty bat, a foam, a sponge, a reticulated foam, a vacuum-formed laminate, a scrim, ≪ / RTI > More preferably, the nonwoven layer comprises a material selected from the group consisting of a cellulose nonwoven, a non-lofty nonwoven, a molded film, a lofty batting, and combinations thereof. As used herein, the term " nonwoven fabric " means that the layer does not include fibers knitted into a knitted fabric, but the layer does not need to contain any fibers at all, such as a molded film, sponge, foam, When the layer contains fibers, the fibers can be randomized (i.e., randomly arranged) or carded (i.e., carded oriented primarily in one direction). In addition, the layer may be a composite material comprising additional layers, i. E. Combinations of ply, and random, carded fibers.

In one embodiment, the nonwoven layer of the substrate comprises a bet. Preferably, the nonwoven layer is lofty, non-abrasive, and low density. Where "Lofty" used layer has a density of from about 0.00005 g / cm ³ to about 0.1 g / cm ^3, preferably from about 0.001 g / cm ³ to about 0.09 g / cm ^3, 5 in gms / in ² And has a thickness of about 0.04 inches to about 2 inches. The nonwoven layer comprising betting preferably contains a synthetic material. &Quot; Synthetic " as used herein means that the material is obtained primarily from a variety of materials made by man or additionally modified natural materials. Suitable synthetic materials include, but are not limited to, acetate fibers, acrylic fibers, cellulose ester fibers, modacryl fibers, polyamide fibers, polyester fibers, polyolefin fibers, polyvinyl alcohol fibers, rayon fibers, polyethylene foams, polyurethane foams, Water, but is not limited thereto. Preferred synthetic materials, particularly fibers, can be selected from the group consisting of nylon fibers, rayon fibers, polyolefin fibers, polyester fibers, and combinations thereof. Preferred polyolefin fibers are fibers selected from the group consisting of polyethylene, polypropylene, polybutylene, polypentene, and combinations and copolymers thereof. More preferred polyolefin fibers are fibers selected from the group consisting of polyethylene, polypropylene, and combinations and copolymers thereof. Preferred polyester fibers are fibers selected from the group consisting of polyethylene terephthalate, polybutylene terephthalate, polycyclohexylenedimethylene terephthalate, and combinations and copolymers thereof. More preferred polyester fibers are fibers selected from the group consisting of polyethylene terephthalate, polybutylene terephthalate, and combinations and copolymers thereof. The most preferred synthetic fibers contain short single-color polyester fibers containing a polyethylene terephthalate homopolymer. Suitable synthetic materials include, but are not limited to, monochromatic single component (i.e., chemically homogeneous) fibers, multicomponent fibers (i.e., one excess type of material making up each fiber), and multicomponent fibers Synthetic fibers containing two or more distinct filament types intertwined), and combinations thereof. Preferred fibers include bicomponent fibers, multicomponent fibers, and combinations thereof. The bicomponent fibers may be in a core-sheath arrangement or a side-by-side arrangement. In each case, the nonwoven layer may contain fibers comprising a combination of fibers containing the listed materials or a combination of the materials listed above as such.

A core-sheath fiber is that with respect to, preferably, the core comprises a material selected from the group consisting of polyester, polyolefin, and combinations thereof having at least about 10 ℃ higher T _g than the sheath material. Conversely, the sheath of bicomponent fibers preferably comprises a polyolefin having a T _g of at least about 10 캜 lower than the core material, a polyester polyolefin having a T _g of at least about 10 캜 lower than the core material, and combinations thereof Contains the substance of choice.

In any case of a side-by-side arrangement, a core-sheath arrangement, or a monochrome single component arrangement, the fibers of the nonwoven layer may represent spiral or spiral or pleated arrangements, in particular bicomponent fibers.

The batting nonwoven layer may also contain natural fibers.

In addition, the fibers of the batting nonwoven layer preferably have an average thickness of from about 0.5 microns to about 150 microns. More preferably, the average thickness of the fibers is from about 5 microns to about 75 microns. In an even more preferred embodiment, the average thickness of the fibers is from about 8 microns to about 40 microns. In addition, the fibers of the nonwoven layer can have various sizes. That is, the fibers of the nonwoven layer may contain fibers having different average thicknesses. The cross-section of the fibers may also be round, flat, oval, elliptical, or other shapes.

In another embodiment, the nonwoven layers of the present invention may be bonded together in a composite, i. E., Continuously (e. G., Laminated, etc.) or in a discontinuous pattern, or bonded together at the outer edge (or periphery) and / By binding, they may contain materials that have one or more ply of the same or different suitable materials that are only physically superimposed. For example, the nonwoven layer may further comprise a composite selected from the group consisting of fibrous nonwoven, sponge, foam, reticulated foam, polymeric net, scrim, vacuum-forming laminate, . It is preferred that the layer of the vacuum-formed nonwoven fabric layer contains a molded film composite containing at least one nonwoven fabric and at least one molded film. Suitable molded film composites include, but are not limited to, a vacuum laminated composite formed film material formed from a combination of a forming film and a carded polypropylene nonwoven fabric having a basis weight of 30 gsm.

In another preferred embodiment, the nonwoven layer is apertured. The voids in the nonwoven layer of the water-insoluble substrate will typically range in average diameter from about 0.5 mm to 5 mm. More preferably, the size of the pores will range from about 1 mm to 4 mm in size of the average diameter. Preferably, about 10% or less of the voids in the nonwoven fabric layer of the substrate will deviate from the size range. More preferably, about 5% or less of the voids of the nonwoven layer will be out of the size range. For a cavity whose shape is not circular, the "diameter" of the cavity refers to the diameter of the circular opening having the same surface area as the opening of the non-circular cavity.

Within the nonwoven layer, the pores will typically be present at a frequency of about 0.5 to 12 pores per linear centimeter. More preferably, the voids in the surface of the layer will be present at a frequency of about 1.5 to 6 voids per linear centimeter.

The void should be located at least in the nonwoven layer. The voids do not have to protrude completely to the other side through one surface of the nonwoven layer. However, these can be. Additionally, the pores may or may not be located in the nonwoven layer of the substrate, so that the article may be voided through its entire volume.

A void can be formed in the nonwoven layer of the water-insoluble substrate, with the water-insoluble substrate or layer thereof being formed or fabricated. Alternatively, after the substrate comprising the layer is completely formed, a void may be formed in the nonwoven layer.

The nonwoven layer may contain a variety of natural and synthetic fibers or materials. &Quot; Natural " means that the substance is derived from plants, animals, insects or by-products of plants, animals, and insects. Conventional base starting materials are usually fibrous webs containing any of the conventional synthetic or natural fabric-length fibers or combinations thereof.

Non-limiting examples of natural materials useful in the present invention include, but are not limited to, silk fibers, keratin fibers, and cellulosic fibers. Non-limiting examples of keratin fibers include those selected from the group consisting of wool fibers, camel hair fibers, and the like. Non-limiting examples of cellulosic fibers include those selected from the group consisting of wood pulp fibers, cotton fibers, hemp fibers, jute fibers, flax fibers, and combinations thereof. Cellulose fiber materials are preferred in the present invention.

Non-limiting examples of synthetic materials useful in the present invention include but are not limited to acetate fibers, acrylic fibers, cellulose ester fibers, modacrylic fibers, polyamide fibers, polyester fibers, polyolefin fibers, polyvinyl alcohol fibers, rayon fibers, polyethylene foams, poly Urethane foam, and combinations thereof. Examples of suitable synthetic materials include acrylic-based and acrylonitrile-based fibers such as acryllane, creslan, orrone; Cellulose ester fibers such as cellulose acetate, arnel and ascel; Polyamides such as nylon (for example, nylon 6, nylon 66, nylon 610 and the like); Polyesters such as Fortran, Cordel, polyethylene terephthalate fiber, polybutylene terephthalate fiber, Darkron; Polyolefins such as polypropylene and polyethylene; Polyvinyl acetate fibers; Polyurethane foams, and combinations thereof. These or other suitable fibers and nonwoven fabrics made therefrom are generally described in Riedel, " Nonwoven Bonding Methods and Materials ", Nonwoven World (1987); The Encyclopedia Americana , Vol. 11, pp. Pp. 147-153, and vol. 26, pp. 566-581 (1984); USP 4,891,227, issued Feb. 1, 1990 to Thaman et al .; And USP 4,891,228, all of which are incorporated herein by reference.

Nonwoven fabrics made from natural materials most commonly consist of a web or sheet formed on a fine wire screen from a liquid suspension of fibers. See CA Hampel et al., The Encyclopedia of Chemistry , 3rd ed., 1973, pp. 793-795 (1973); The Encyclopedia Americana , vol. 376-383 (1984); And GA Smook, Handbook of Pulp and Paper Technologies , Technical Association for Pulp and Paper Industry (1986); All of which are incorporated herein by reference.

Natural material nonwovens useful in the present invention can be obtained from a wide variety of commercial sources. Non-limiting examples of suitable and commercially available suitable paper layers herein include: Airtex < RTI ID = 0.0 > , An emblaced and airlaid cellulosic layer having a basis weight of about 71 gsy, manufactured by James River, Green Bay, WI; And Walkisoft , Walkisoft USA, Mount Holly, NC, with an embossed, air-laid cellulosic layer having a basis weight of about 75 gsy. In manufacturing.

Additional suitable nonwoven materials include those disclosed in U.S. Patent 4,447,294 (Osborn, May 8, 1984), 4,603,176 (Bjorkquist, July 29, 1986), each of which is incorporated herein by reference in its entirety Granted); 4,981, 557 (Bjorkquist, granted 1 January 1991); 5,085, 736 (Bjorkquist, issued Feb. 4, 1992); 5,138,002 (Bjorkquist, issued Aug. 8, 1992); 5,262,007 (Phan et al., Granted November 16, 1993); 5,264,082 (Phan et al., Issued November 23, 1993); 4,637, 859 (Trokhan, issued January 20, 1987); 4,529,480 (Trokhan, issued July 16, 1985); 4,687,153 (McNeil, issued Aug. 18, 1987); 5,223, 096 (Phan et al., Issued June 29, 1993); And 5,679,222 (Rasch et al., Issued October 21, 1997), the disclosure of which is incorporated herein by reference.

Methods for making nonwoven fabrics are well known in the art. In general, these nonwoven fabrics can be made by air-laying, water-laid, meltblown, coformimg, spunbonding, or carding processes wherein the fibers or filaments Is first cut from the long fibers to a desired length, passed through a water or air stream, and then passed through the screen with fiber-loaded air or water to deposit thereon. The resulting layer is then subjected to one or more different types of bonding operations, regardless of its method of manufacture or composition, so that individual fibers are anchored together to form a self-sustaining web. In the present invention, the nonwoven layer may be manufactured by a variety of processes, such as, but not limited to, air-entanglement, hydroentanglement, thermal bonding, and combinations of these processes.

Nonwovens made from synthetic materials useful in the present invention can be obtained from a wide variety of commercial sources. Non-limiting examples of suitable nonwoven layer materials useful herein include: HEF 40-047, voided with about 50% rayon and 50% polyester and having a basis weight of about 61 grams per square meter (gsm) , Apertured hydroentangled material, available from Veratec Inc., Walpole, MA; Wet entangled material containing HEF 140-102, about 50% rayon and 50% polyester and having a basis weight of about 67 gsm, available from Veratec Inc., Walpole, MA; Novonet 149-616, a thermo-bonded grid patterned material containing about 100% polypropylene and having a basis weight of about 60 gsm, available from Veratec Inc., Walpole, Mass .; Novonet 149-801, a thermally bonded lattice material containing about 69% rayon, about 25% polypropylene and about 6% cotton and having a basis weight of about 90 gsm, available from Veratec Inc., Walpole, MA; Novonet 149-191, about 69% rayon, about 25% polypropylene, about 6% cotton, and a basis weight of about 120 gsm, available from Veratec Inc., Walpole, MA; HEF Nubtex ^(R) 149-801, a nubbed, pore-formed, wet-knit material containing about 100% polyester and having a basis weight of about 84 gsm, available from Veratec Inc., Walpole, MA; Keybak 951 V, about 75% rayon, about 25% acrylic fiber, and having a basis weight of about 51 gsm, commercially available from Chicopee, New Brunswick, NJ; Keybak 1368, about 75% rayon, pore-formed material containing about 25% polyester and having a basis weight of about 47 gsm, available from Chicopee, New Brunswick, NJ; Duralace 1236, pore-forming, wet-knit material containing about 100% rayon and having a basis weight of from about 48 gsm to about 138 gsm, available from Chicopee, New Brunswick, NJ; Duralace 5904, pore-forming, wet-knit material containing about 100% polyester and having a basis weight of about 48 gsm to about 138 gsm, available from Chicopee, New Brunswick, NJ; Chicopee 5763, about 70% rayon, about 30% polyester, and optionally about 5% w / w or less latex binder (based on acrylate or EVA) and having a basis weight of about 60 gsm to about 90 gsm Wet entangled material (8 x 6 voids per inch, 3 x 2 voids per cm), available from Chicopee, New Brunswick, NJ; Chicopee 50% polyester to 0% rayon / 100%), 100% rayon / 9900 series (e.g. Chicopee 9931, 62 gsm, 50/50 rayon / polyester and Chicopee 9950 50 gsm, 50/50 rayon / polyester) Wet, entangled material containing a fiber composition of 100% polyester or 100% rayon / 0% polyester and having a basis weight of about 36 gsm to about 84 gsm, available from Chicopee, New Brunswick, NJ; Sontara 8868, a wet tangled material containing about 50% cellulose and about 50% polyester and having a basis weight of about 72 gsm, available from Dupont Chemical Corp. Preferred nonwoven substrate materials have a basis weight of from about 24 gsm to about 96 gsm, more preferably from about 36 gsm to about 84 gsm, and most preferably from about 42 gsm to about 78 gsm.

The nonwoven layer may also be a polymeric mesh sponge as described in European Patent Application No. 702550 Al, published March 27, 1996, the entirety of which is incorporated herein by reference. The polymeric mesh sponge comprises several layers of extruded tubular net meshes made of polymers or nylons with strong stretch properties such as polyamides of olefinic monomers and polyamides of polycarboxylic acids.

The nonwoven layer may also include multiple materials including molded films and composites, such as molded films. Preferably, the forming film comprises plastic that tends to soften the skin. Suitable soft plastic forming films include, but are not limited to, polyolefins such as low density polyethylene (LDPE). If the nonwoven layer comprises a plastic formed film, it is preferred that the nonwoven layer is voided, for example microapertured, or microapertured, so that the layer is fluid permeable. In one embodiment, the nonwoven layer comprises a plastic forming film having only micropores formed thereon. The surface aberration, i.e. the male side, of the micropores is preferably located on the inner surface of the second layer, preferably towards the interior of the substrate, i.e. the therapeutic efficacy member. In certain embodiments that include voids with petal-like edge surface deformations, regardless of theory, the application of pressure to the article by hand, when the surface deformation of the voids faces the therapeutic efficacy member, It is believed that by folding the mold edge into the interior it is possible to create numerous valves on the inner surface of the layer that actually meter out the absence of therapeutic efficacy contained in the article to extend the useful life of the article.

In another embodiment, the nonwoven layer comprises a plastic formed film having both micropores and macropores. In this embodiment, the nonwoven layer is well suited for contacting the micropores at the site to be treated therapeutically while providing a cloth-like feel of the formed film. Preferably, in this embodiment, the surface deformation of the micropores is directed against the surface deformation of the macropores on the nonwoven layer. In this case, the large voids are judged to form rich foam by maximizing the overall wetting / foaming of the article by the three-dimensional thickness formed from surface deformation under constant compression and decompression during use of the article.

In any case, the nonwoven layer containing the forming film has a porosity of at least about 100 voids / cm ² , more preferably at least 500 voids / cm ² , even more preferably at least about 1000 voids / cm ² , it has a void / ㎝ ² of the substrate at least about 1500. A more preferred embodiment of the present invention is a solution of about 5 cm ³ / cm ² -s to about 70 cm ³ / cm ² -s, more preferably about 10 cm ³ / cm ² -s to about 50 cm ³ / cm ² - s, most preferably from about 15 cm ³ / cm ² -s to about 40 cm ³ / cm ² -s.

Suitable molded films and molded film-containing composites useful in the nonwoven layer of the present invention include those disclosed in U.S. Patent No. 4,342,314 (Radel et al., Issued August 3, 1982), each of which is incorporated herein by reference in its entirety (U.S. Patent Application Serial No. 08 / 326,571, filed June 12, 1995, and U.S. Patent Application No. 4,629,643, filed June 11, 1995, both of which are incorporated herein by reference in their entirety) , Issued Dec. 16, 1986), but are not limited thereto. In addition, the nonwoven layer can be a molded film composite that includes at least one formed film and at least one nonwoven fabric in which the layer is formed in vacuum. Suitable molded film composites include, but are not limited to, vacuum laminated composite formed film materials formed by combining a molded film and a carded polypropylene nonwoven having a basis weight of 30 gsm.

Additionally, the nonwoven layer and any additional layers are preferably bonded together to maintain the integrity of the article. The bonding may be effected by bonding at the outer edge (or periphery) of the layer and / or at a specific location or combination thereof, or by spot bonding (e.g., hot point bonding), continuous bonding , Laminated, etc.). When spot bonding is used in the present article, the spot bonding is preferably separated by a distance of about 1 cm or more. However, in certain instances, bonding may be arranged to be formed on the outer surface of the article and layer in which geometric shapes and patterns, such as diamonds, circles, squares, etc., are produced.

Also in the article of the present invention, the nonwoven layer and any additional layers may be modified surfaces to form a single composite layer having two sides with different textures. Thus, in practice, the water-insoluble substrate may be understood to comprise a single composite layer with a bi-textured side or surface.

In any case, the bonding area present between the nonwoven layer and any additional layers is at most about 50%, preferably at most about 15%, more preferably at most about 10% of the total surface area of the layer, About 8% or less.

Each layer discussed herein may include two or more surfaces, i. E. An inner surface and an outer surface, each having the same or different texture and abrasive. Preferably, the article of the invention contains a substrate and thus a soft layer on the skin. However, the different textured substrates may be due to the use of different combinations of materials or the use of different manufacturing processes or combinations thereof. For example, a bi-textured water-insoluble substrate can be prepared to provide a more abrasive side for exfoliation and an advantageous personal care article having a milder cleansing and / or softer, absorbent aspect for therapeutic treatment . It is also possible to further assist the user to distinguish the surface by manufacturing the individual layers of the substrate to have different tints.

In addition, each of the layers of the article and the article per se can be manufactured in a wide variety of shapes and forms, such as flat pads, thick pads, thin sheets, ball-like tools, and irregular tools. The exact size of the layer will depend on the intended use and the properties of the article, and the surface area may range from about 1 in ² to about several hundred in ² . Particularly convenient layer and article shapes have a surface area of from about 5 in ² to about 200 in ² , preferably from about 6 in ² to about 120 in ² , more preferably from about 15 in ² to about 100 in ² , circular, rectangular, hourglass, mitt, or oval having a thickness of from about 1 mm to about 50 mm, more preferably from about 1 mm to about 25 mm, and more preferably from about 2 mm to about 20 mm, But are not limited thereto.

Wear Value Methodology

The wear value represents the " non-abrasive " property of the nonwoven layer of the article. The nonwoven fabric layer of the present invention exfoliates gently but is not rough on the skin. The wear value measurement thus involves rubbing the substrate along the test surface using a mechanical device and then testing the scratch marks created on the test surface using different analytical techniques.

The following apparatus is required in the methodology.

1. Martindale toothbrush wear and abrasion tester: Model 103, serial number 103-1386 / 2 or higher. James H. Heal and Co. Ltd. Martindale 07-01-88 < / RTI > Fabric testing and QC equipment. Foot area: 43 × 44 mm. 1 kg weight.

2. Capped polystyrene slices 11 x 8 cm. A clean conventional polystyrene layer on white high impact polystyrene, for example EMA Model Supplies SS-20201L.

3. The substrate to be tested.

4. Gloss system such as Sheen Tri-Microgloss 20-60-85.

Remove the plastic protective coating from the side to be scrubbed and rinse with ethanol (no tissue is used) to produce a piece of polystyrene for scratching. Place the piece on a non-abrasive surface and allow the piece to dry in air. Then attach polystyrene pieces to the bottom of the Martindale wear tester using tape along the edges. Align the pieces in the center under the path of the scrub device so that the length of the piece is in the direction of movement. A 2.5 " x 2.5 " substrate sample is cut. Using a double-sided tape, the substrate sample is attached to the scrub foot of the Martindale wear tester to align the machine direction of the substrate in the direction of travel. While supplying the screw, insert the scrub foot assembly into the instrument. Place a weight of 1 kg on top of the scrub foot assembly and allow the scrub foot to move in only one direction (forward and backward). Cover Martindale wear testers with a safety screen. Set and operate the machine to perform 50 cycles per minute (frequency = 0.833 Hz). Once the machine stops, remove the foot assembly and remove the polystyrene pieces from the bottom of the machine. The polystyrene representing the substrate used is labeled and stored in a plastic bag.

The pieces are then analyzed. Place the piece on the black construction paper background and analyze more than 5 samples of the same substrate to obtain a reproducible average. The polishmeter is placed perpendicular to the scratched side of the polystyrene piece (with the light beam perpendicular to the scratch) and centered. A 20 DEG angle is selected and the sample is measured to obtain a wear value. As the wear value decreases, the scratch or wear properties of the substrate increase.

Absence of therapeutic efficacy

The article of the invention further comprises a safe effective amount of a therapeutic benefit member. The efficacious member is disposed adjacent to the water insoluble substrate and contains from about 10% to about 1000% by weight of the water insoluble substrate of the therapeutic efficacy composition. The efficacious composition further comprises a safe effective amount of a cationic polymer and a safe effective amount of an anionic surfactant, wherein said composition forms a coacervate when said article is exposed to water.

Cationic polymer

The personal care composition of the present invention contains a safe effective amount of a cationic polymer. The cationic polymer may be selected from the group consisting of natural backbone quaternary ammonium polymers, synthetic backbone quaternary ammonium polymers, natural backbone ampholytic polymers, synthetic backbone ampholytic polymers, and combinations thereof.

The cationic polymer preferably has a molecular weight of greater than about 0.05 meq / gm, more preferably greater than about 0.1 meq / gm, more preferably greater than about 0.2 meq / gm, even more preferably greater than about 0.5 meq / gm, Shows a charge density of greater than about 1 meq / gm.

The molecular weight of the cationic polymer is preferably greater than about 250, more preferably greater than about 350, even more preferably greater than about 450, and most preferably greater than about 500.

More preferably, the cationic polymer is selected from the group consisting of polyquaternium-4, polyquaternium-10, polyquaternium-24, PG-hydroxyethylcellulose alkyldiammonium chloride, guar hydroxypropyl trimonium chloride, A natural backbone quaternary ammonium polymer selected from the group consisting of hydroxypropyltrimethoxypropyltrimonium chloride, hydroxypropylglyhydroxypropyltrimonium chloride, and combinations thereof; Polyquaternium-6, polyquaternium-7, polyquaternium-11 polyquaternium-16, polyquaternium-17, polyquaternium-18, polyquaternium-28, polyquaternium- -32, polyquaternium-37, polyquaternium-43, polyquaternium-44, polyquaternium-46, polymethacylamidopropyltrimonium chloride, acrylamidopropyltrimonium chloride / acrylamide copolymer, A synthetic backbone quaternary ammonium polymer selected from the group consisting of combinations thereof; A natural backbone ampholytic polymer selected from the group consisting of chitosan, quaternized proteins, hydrolyzed proteins and combinations thereof; Polyquaternium-22, polyquaternium-39, polyquaternium-47, adipic acid / dimethylaminohydroxypropyl diethylenetriamine copolymer, polyvinylpyrrolidone / dimethylaminoethyl methacrylate copolymer, vinyl Caprolactam / polyvinylpyrrolidone / dimethylaminoethyl methacrylate copolymer, vinylcaprolactam / polyvinylpyrrolidone / dimethylaminopropyl methacrylamide terpolymer, polyvinylpyrrolidone / dimethylaminopropyl methacrylamide copolymer And a synthetic backbone ampholytic polymer selected from the group consisting of polyamines, polyamines, and combinations thereof. Even more preferably, the cationic polymer is a synthetic backbone amphoteric polymer. Even more preferably, the cationic polymer is a polyamine.

When the cationic polymer is a polyamine, the cationic polyamine polymer is preferably selected from the group consisting of polyethyleneimine, polyvinylamine, polypropyleneimine, polylysine, and combinations thereof. Even more preferably, the cationic polyamine polymer is a polyethyleneimine.

In certain embodiments in which the cationic polymer is a polyamine, the polyamine can be modified hydrophobically or hydrophilically. In the above examples, the cationic polyamine polymer is selected from the group consisting of benzylated polyamines, ethoxylated polyamines, propoxylated polyamines, alkylated polyamines, amidated polyamines, esterified polyamines, and combinations thereof. The coacervate forming composition comprises from about 0.01% to about 20%, more preferably from about 0.05% to about 10%, most preferably from about 0.1% to about 5% by weight of the cationic polymer of the coacervate forming composition .

Anionic surfactant

The coacervate composition of the present invention also contains an anionic surfactant. Without wishing to be bound by theory, it is believed that anionic surfactants interact with cationic polymers, partially reducing cationic charge density, reducing solubility, and enhancing deposition on the skin. The composition preferably comprises from about 10% to about 1,000%, preferably from about 50% to about 600%, more preferably from about 100% to about 250% of an anionic interface It contains an active agent.

A wide variety of anionic surfactants are suitable for use in the compositions of the present invention (see Laughlin, et al., USP 2,929,678, issued Dec. 30, 1975). Non-limiting examples of anionic surfactants include acyl isethionates (e.g., C ₁₂ -C ₃₀ ), alkyl and alkyl ether sulfates and salts thereof, alkyl and alkyl ether phosphates and salts thereof, and alkyl methyl taurates , C ₁₂ -C ₃₀ ), monoalkanolamine phosphates and soaps of fatty acids (eg, alkali metal salts such as sodium or potassium salts). Preferably, for the coacervate forming composition, the anionic surfactant Sodium alkylate, sodium alkylate sulfate, ammonium alkylsulfate, ammonium laureth-n-sulfate, sodium laureth-n-sulfate, isethionate, Glyceryl ether sulfonate, sulfosuccinate, monoalkanolamine phosphate, and combinations thereof. More preferably, the anionic surfactant is selected from the group consisting of sodium lauroyl sarcosinate, monosodium lauroyl glutamate, sodium alkyl sulfate, ammonium alkyl sulfate, sodium alkyl ethosulfate, ammonium alkyl ethosulfate, Amine phosphates, and combinations thereof.

Without wishing to be bound by theory, it is believed that the cationic polymer and the anionic surfactant coexist in the form of a coacervate when exposed to an aqueous medium. As used herein, " coacervate " refers to the associative phase separation of polymers by reverse charged polymers and surfactants or by polymer and product dilution. The result is an aqueous gel-like substance, coacervate, which is formed. Once formed, the appearance of dry skin once applied with the coacervate alone in the composition can be improved. In addition, such coacervate acts as a mechanism for the deposition of an efficacy therapeutic agent, which can promote the substantivity of such material to the skin. As the persistence of the material to the skin and / or hair increases, the effect of the material increases.

pH

When the article is exposed to water, the therapeutic efficacy composition of the present invention exhibits a pH of from about 4 to about 10. Preferably, the pH is about 4.5 to 9.5, more preferably about 5 to 9.

Surface versus saturation non-methodology

The articles of the present invention contain substantially no therapeutic benefit on the surface of the substrate. The expression " substantially on the surface of the substrate " means that the surface to saturation ratio is greater than about 1.25, preferably greater than about 1.5, more preferably greater than about 2.0, even more preferably greater than about 2.25, It means excess. The surface to saturation ratio is a measure of the agonist on the surface of the substrate. These measurements were obtained using an Attenuated Total Reflectance (ATR) FT-IR spectrometer well known to those skilled in the art of analytical chemistry.

Many existing methods of applying conditioning agents to substrates utilize process and / or product rheology unsuitable for the purposes of the present invention. As an example, a so-called " dip and nip " process, in which a substrate web is immersed in a fluid bath of a conditioning agent and then the substrate web is pressed through a metering roll, , There is no opportunity for effective direct delivery of the composition out of the fabric and onto other surfaces during use. In addition, many of the articles of the present invention provide effective overall body efficacy using sufficient loading of the conditioning agent onto the substrate, which generally requires a loading rate of about 100% to 200% by weight of the dry substrate. Known personal care tools that take advantage of this high loading level essentially avoid addressing aesthetic problems that can result from high loading by distributing the loading uniformly throughout the substrate, including inside the substrate. Applicants have surprisingly found that a high loading conditioning agent can be retained on the surface of the article and thus the opportunity of direct delivery of the agonist to the surface being treated from the substrate during use can advantageously be met, Thereby providing improved aesthetics.

The measurement procedure is as follows.

Instrument set-up : A BioRad FTS-7 spectrometer from Bio Rad Labs, Digital Laboratory Division, Cambridge, Mass., Was used to collect infrared spectra. Typically, 100 scans were measured at a resolution of 4 cm ^-1 . The collection optics are Graseby Specac, Inc. (Located in the CT pair field) of a flat 60 degree ZnSe ATR crystal. Data were collected at 25 < 0 > C and analyzed by Galactic Industries Corp. (Located in Salem, NH) using Grams 386 software. Before measurement, the crystals were washed with an appropriate solvent. The sample was placed in the ATR crystalline phase and held under a constant 4 kg weight.

Experimental Procedure

(1) Measure the reference (background) spectrum of cleaned and air dried cells.

(2) First, a substrate to which no effect agent is applied is selected, and the selected substrate constitutes the outer surface of the article. ATR crystals, place the substrate on top of the outer surface for crystallization. First, the substrate is placed flat on the measuring platform. Thereafter, a weight of 4 kg is placed on the substrate. The spectrum is then measured (typically 100 scans at 4 cm ^-1 resolution). Since the absorbance of the substrate alone is confirmed, the substrate functions as an internal standard. Check the major base peaks and wavelengths.

(3) Repeat the process for the description of the article to which the efficacy is applied. Does not correspond to the same base peaks as previously observed; Or the peak height of the primary efficants which correspond to the previously observed base peaks but which are the highest observation peaks showing a significant percentage increase in absorbance due to the presence of the conditioning agent. Record the wavelength number and absorbance of several effector peaks.

(4) From the spectrum determined in the third step, a base peak which is generated at the wavelength determined in the second step but does not correspond to one of the primary effector peaks selected in the third step is selected. Record the wavelength number and the absorbance selected from the absorption spectrum of the third step.

(5) For the peak height of the substrate determined in step 4, calculate the ratio of the peak height of each agonist determined in step 3. The highest number of groups represents the surface to saturation ratio of the article.

The following includes some examples:

materials* Base Peak and Peak Height conditioner for hair Conditioner peak height ratio Betting (a blend of thermally bonded polyester with 70% PET / PE bicomponent fibers) 0.0865 (C = O peak at 1710 cm ^-1 ) Glycerin (CO peak at 1030 cm ^-1 ) 0.181 2.09 Betting (a blend of thermally bonded polyester with 70% PET / PE bicomponent fibers) 0.0865 (C = O peak at 1710 cm ^-1 ) Hydrocarbons (CH peak at 2923 cm ^-1 ) 0.160 1.85 Wet tangled 70% rayon / 30% polyester 0.0333 (C = O peak at 1710 cm ^-1 ) Glycerin (CO peak at 1030 cm ^-1 ) 0.0684 2.05

* This type of substrate is readily available, for example, from PGI Nonwovens (Benson, NC).

Water conservancy methodology

As described above, the articles of the present invention are considered to be " substantially dry ". The expression " substantially dry ", as used herein, means that the articles of the present invention exhibit less than about 0.95 gms, preferably less than about 0.75 gms, more preferably less than about 0.5 gms, more preferably less than about 0.25 gms, Means a water holding capacity of less than about 0.15 gms, and most preferably less than about 0.1 gms. The water holding capacity is a measure of dry feeling as opposed to a " wet " towel feel when users touch the article of the present invention.

In order to determine the water holding capacity of products based on the present invention and other disposable substrates, the following equipment and materials are required.

Bounty White Paper Towel Procter & Gamble SKU37000 63037 basis weight = 42.14gsm Scale Adjust to exactly 0.0g Lexan 0.5 " thick < / RTI > sufficiently large to completely cover the sample, Weight 2000g weight or even combination to 2000g

Then, weigh each two paper towels and record them. Place a piece of paper towel on a flat surface (for example, a laboratory bench). The sample article is placed on the towel. Place another piece of paper towel on top of the sample item. Then place Lexan and place 2000g weight (s) on the sandwiched sample article. Wait one minute. After one minute, remove the weight (s) and Lexan. Weigh the paper towel on the top and bottom of the sample and record the weight.

For both the top and bottom paper towels, subtract the initial paper towel weight from the final weight (after one minute) to calculate the water holding capacity. The weight differences obtained for the paper towels on the top and bottom are summed. Assuming that a number of items have been tested, calculate the water holding capacity by averaging the total weight differences.

Example of composite product implementation

The articles of the present invention may also be packaged with additional items suitable for providing efficacies, such as cosmetic, therapeutic, functional, etc., that are not individually or provided by the primary article, have. Additional articles of such personal care kits preferably contain a water insoluble substrate comprising one or more layers and a cleansing component containing a therapeutic active ingredient or a foam-forming surfactant disposed or impregnated in a base layer of the additional article .

The additional articles of the invention may also provide functional efficacy in addition to or in place of therapeutic or cosmetic efficacy. By way of example, the additional article can be used as a drying tool suitable for being used to help remove water from the skin or hair after the shower or bath is over.

Multi-Chamber Implementation Example

The articles of the present invention may include one or more chambers. Such chambers or compartments are due to the connection (e.g., bonding) of the substrate layers with other layers at various locations, which limits the enclosed area. Such chambers are useful, for example, for separating the various ingredient components from one another, for example as a surfactant-containing cleansing component, in a conditioning agent. Separate article members that provide therapeutic or cosmetic or cleansing efficacy may be used to remove or modify the components of the chamber such as, but not limited to, solubilization, emulsification, mechanical transport, puncturing, popping, rupturing, squeezing, And may be released from the chambers in a variety of ways, including peeling of the substrate layer.

Arbitrary member

The article of the present invention may contain various other elements commonly used in the form of a given product, provided that they do not alter the benefits of the invention to an unacceptable degree. It will be appreciated that the optional components should be suitable for application to human skin and hair, i.e., when incorporated into an article, they may be administered to humans and / or human beings within a sound medical or formulator's judgment without undue toxicity, incompatibility, instability, It should be suitable for use in contact with the skin. The CTFA Cosmetic Ingredient Handbook, Second Edition (1992) describes a wide variety of non-limiting cosmetic and pharmaceutical ingredients commonly used in the skin care industry, suitable for use in the articles of the present invention. Examples of the component group include: enzymes, abrasives, skin exfoliants, absorbents, cosmetic ingredients such as fragrances, pigments, colorants / colorants, essential oils, skin sensitizers, astringents and the like Antiseptic agents (e.g., resorcinol, sulfur, salicylic acid, erythromycin, zinc, etc.), antioxidants (e. G., Oils, menthol, camphor, eucalyptus oil, eugenol, menthyl lactate, Anti-oxidants, binders, biological additives, buffering agents, bulking agents, chelating agents, chemical additives, coloring agents, cosmetic astringents (for example, anti-foaming agents) , Polymers for assisting film-forming properties and realism of compositions, such as cosmetic biocides, modifiers, drug astringents, external analgesics, film formers or materials such as eicosene and vinylpyrrolidone (Or a lightening agent) (e.g., hydroquinone, kojic acid, ascorbic acid, magnesium ascorbyl phosphate, ascorbyl glucosamine, or a combination thereof), a wetting agent, an opacifying agent, a pH adjusting agent, a propellant, ), Skin soothing and / or healing agents (e.g., panthenol and derivatives (e.g., ethyl panthenol), aloe vera, pantothenic acid and its derivatives, allantoin, bisabolol, and diphotassium glycyrrhizinate) (E. G., Alpha-hydroxy acids such as lactic acid and glycolic acid and beta-hydroxy acids such as salicylic acid), thickeners, hydrocolloids, Specific zeolites, and vitamins and derivatives thereof (e.g., tocopherol, tocopherol acetate, beta carotene, retinoic acid, retinol, retinoid, retinyl palmitate, Neu, niacinamide, etc.). The articles of the present invention may comprise carrier ingredients known in the art. The carrier may comprise one or more miscible liquids or solid filler diluents or Vecich, suitable for application to the skin or hair.

The article of the present invention may optionally comprise one or more of the optional ingredients. Preferred articles are, optionally, vitamins, skin treatments, anti-acne activators, anti-wrinkle activators, anti-skin atrophy activators, anti-inflammatory actives, topical anesthetics, artificial tanning activators and accelerators, antimicrobial activators, A therapeutically effective amount of a therapeutic agent selected from the group consisting of an anti-oxidant, an anti-oxidant, an antifungal agent, a sunscreen active, an anti-oxidant, a skin exfoliant, and combinations thereof. As used herein, a " safe effective amount " is sufficient to significantly induce a positive effect or efficacy, but it should be understood that a reasonable efficacy-to-risk ratio under acceptable medical judgment is sufficient to avoid serious side effects (e.g., excessive toxicity or allergic response) ≪ RTI ID = 0.0 > and / or < / RTI >

Any ingredient useful herein may be categorized by the therapeutic or aesthetic efficacy of the action or by its assumed mode. However, any ingredient useful herein may, in some cases, provide one or more therapeutic or cosmetic efficacies or act through one or more forms of action. Thus, the classifications herein are for convenience only and are not intended to limit the ingredients for any particular application or listed application. Also, where applicable, pharmaceutically acceptable salts of the components are useful herein.

Anionic polymer

The article of the present invention may optionally contain an anionic polymer. Suitable anionic polymers include, but are not limited to, polyacrylic acid polymers, polyacrylamide polymers, copolymers of acrylic acid, acrylamide, and other natural or synthetic polymers such as polystyrene, polybutene, polyurethane, A combination thereof, and the like. Suitable gums include alginates (e.g., propylene glycol alginate), pectin, chitosan (e.g., chitosan lactate), and modified gums (such as starch octenyl succinate), and combinations thereof. More preferably, the anionic polymer is selected from the group consisting of a polyacrylic acid polymer, a polyacrylamide polymer, pectin, chitosan, and combinations thereof. Preferred articles of the present invention comprise from about 0.01% to about 20%, more preferably from about 0.05% to about 10%, most preferably from about 0.1% to about 5%, by weight of the anion- Polymer.

Vitamin compound

The articles of the present invention may contain vitamin compounds, precursors, and derivatives thereof. These vitamin compounds may be in natural or synthetic form. Examples of suitable vitamin compounds include vitamin A (e.g., beta carotene, retinoic acid, retinol, retinoid, retinyl palmitate, retinyl propionate and the like), vitamin B (e.g., niacin, niacinamide, riboflavin, pantothenic acid, Vitamin E (e.g., tocopherol acetate, etc.), vitamin K (e.g., phytonadione, Mena, etc.), vitamin C (e.g., ascorbic acid and the like), vitamin D (e.g., ergosterol, ergocalciferol, cholecalciferol, Dione, petiolecol, etc.) compounds.

In particular, the article of the present invention may contain a vitamin B ₃ compound in an effective amount of safety. Vitamin B ₃ compounds, the whole being, co-pending, which is reflected by reference in its entirety U.S. Patent Application Serial No. 08 / No. 834 010 (filed April 11, 1997) (International Publication No. WO 97/39733 A1 (October 1997 Quot ;, published on May 30, 1999). The therapeutic component of the present invention preferably comprises from about 0.01% to about 50%, more preferably from about 0.1% to about 10%, even more preferably from about 0.5% to about 10%, even more preferably from about 1% to about 5%, and most preferably the vitamin B ₃ compound of from about 2% to about 5%.

Herein, "vitamin B ₃ compound" used is a compound having the formula to; Derivatives thereof; And salts of any of the foregoing:

Wherein R is -CONH ₂ (i.e., niacinamide), -COOH (i.e., nicotinic acid), or -CH ₂ OH (i.e., nicotinyl alcohol).

Examples of the derivatives of the above-mentioned vitamin B ₃ compounds include nicotinic acid esters including non-vasodilating esters of nicotinic acid, nicotinyl amino acid, nicotinyl alcohol ester of carboxylic acid, nicotinic acid N-oxide and niacinamide N-oxide .

Examples of suitable vitamin B ₃ compounds are well known in the art, a number of sources, e.g., Sigma Chemical Company (St. Louis, MO ); ICN Biomedicals, Inc. (Irvin, Calif.) And Aldrich Chemical Company (Milwaukee, Wis.)

Vitamin compounds can be included as a substantially pure material or as an extract obtained by suitable physical and / or chemical isolation from a natural (e.g., plant) source.

Skin Treatment

The article of the present invention may contain one or more skin treatment agents. Suitable skin treatment agents include those effective for preventing, delaying, stopping, and / or converting skin wrinkles. Examples of suitable skin treatment agents include, but are not limited to, alpha-hydroxy acids such as lactic acid and glycolic acid and beta-hydroxy acids such as salicylic acid.

Anti acne agent

Examples of anti-acne agents useful in the article of the present invention include keratolytic agents such as salicylic acid (o-hydroxybenzoic acid), derivatives of salicylic acid such as 5-octanoylsalicylic acid, and resorcinols; Retinoids such as retinoic acid and derivatives thereof (e.g., cis and trans); Sulfur-containing D and L amino acids and their derivatives and salts, especially their N-acetyl derivatives, preferred examples include N-acetyl-L-cysteine; Lipoic acid; Antibiotics and antimicrobial agents such as benzoyl peroxide, octopirox, tetracycline, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorobanilide , Azelaic acid and its derivatives, phenoxyethanol, phenoxypropanol, phenoxyisopropanol, ethyl acetate, clindamycin and mecocycline; Sebostat, such as flavonoids; And bile acid salts such as, for example, scymnol sulfate and derivatives thereof, deoxycholates, and cholates.

Anti-wrinkle agent and anti-skinning agent

Examples of wrinkle preventing agents and skin irritation preventing agents useful in the articles of the present invention include retinoic acid and derivatives thereof (e.g., cis and trans); Retinol; Retinyl ester; Niacinamide, salicylic acid and derivatives thereof; Sulfur-containing D and L amino acids and their derivatives and salts, especially N-acetyl derivatives, preferred examples of which include N-acetyl-L-cysteine; Thiols, such as ethanethiol; Hydroxysic acid, phytic acid, lipoic acid; Lysophosphatidic acid, and skin exfoliation agents (e.g., phenol and the like).

Non-steroidal anti-inflammatory actives (NSAIDS)

Examples of NSAIDS useful in the articles of the present invention include, but are not limited to, the following categories: propionic acid derivatives; Acetic acid derivatives; Phenanic acid derivatives; Biphenylcarboxylic acid derivatives; And oxycam. All of these NSAIDS are described in detail in U.S. Patent No. 4,985,459 (Sunshine et al., Issued January 15, 1991), which is incorporated herein by reference in its entirety. Examples of useful NSAIDS include, but are not limited to, acetylsalicylic acid, ibuprofen, naproxen, beroxaprofen, fluulbifropen, fenoprofen, penbufen, ketoprofen, indoprofen, , Pranoprofen, miroprofen, thioxaprofen, suroprofen, alminopropone, thiopropenoic acid, fluprofen and bacloxacan. Steroidal anti-inflammatory drugs including hydrocortisone and the like are also useful.

Local anesthetic

Examples of topical anesthetics useful in the articles of the invention include, but are not limited to, benzocaine, lidocaine, bupivacaine, chlorprocaine, dibucaine, etidocaine, mephvacaine, tetracaine, dichlonine, hexylcaine, procaine, cocaine, Ketamine, pramoxine, phenol, and pharmaceutically acceptable salts thereof.

Artificial tanning and accelerating agents

Examples of artificial tanning agents and promoters useful in the articles of the present invention include, but are not limited to, tyrosine esters such as dihydroxyacetone, tyrosine, ethyl tyrosinate, and phospho-DOPA.

Antimicrobial agent and antifungal agent

Examples of antimicrobial agents and antifungal agents useful in the articles of the present invention include, but are not limited to,? -Lactam drugs, quinolone drugs, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, 2,4,4'- trichloro- But are not limited to, carboxymethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose, , Hexamidine, isethionate, metronidazole, pentamidine, gentamicin, kanamycin, linemmaicin, methacycline, methenamine, minocycline, neomycin, nethymicin, paromomycin, streptomycin, tobramycin, Tetracycline hydrochloride, erythromycin, zinc erythromycin, erythromycin esters, erythromycin But are not limited to, stearates, amikacin sulfate, doxycycline hydrochloride, capreomycin sulfate, chlorhexidine gluconate, chlorhexidine hydrochloride, chloretetracycline hydrochloride, oxytetracycline hydrochloride, clindamycin hydrochloride, ethambutol hydrochloride, metronidazole hydrochloride , Pentamidine hydrochloride, gentamicin sulfate, kanamycin sulfate, lincomycin hydrochloride, methacyline hydrochloride, methenamine hydrochloride, methenamine mandelate, minocycline hydrochloride, neomycin sulfate, , Paromomycin sulfate, streptomycin sulfate, tobramycin sulfate, myconezole hydrochloride, amanpadine hydrochloride, amanfadine sulphate Sites, loam rocks, blood, para-chloro-meta-xylenol, age statins, tolyl naphthyl lactate, but containing the zinc pyrithione and clotrimazole, are not limited.

Antiviral agent

The article of the present invention may further contain one or more antiviral agents. Suitable antiviral agents include, but are not limited to, metal salts such as silver nitrate, copper sulfate, iron chloride, and organic acids such as malic acid, salicylic acid, succinic acid, benzoic acid and the like. In particular, compositions containing additional suitable antiviral agents include co-pending U.S. Patent Application Serial No. 09 / 421,084 (Beerse et al.), Filed Oct. 19, 1999; 09 / 421,131 (Biedermann et al.); 09 / 420,646 (Morgan et al.); And 09 / 421,179 (Page et al.).

enzyme

The article of the present invention may optionally comprise one or more enzymes. Preferably, such enzymes are dermatologically acceptable. Suitable enzymes include, but are not limited to, keratinase, protease, amylase, subtilisin, and the like.

Sunscreen

Sunscreens are also useful here. A wide variety of sunscreens are described in U.S. Patent No. 5,087,445 (Haffey et al., Issued Feb. 11, 1992), which is incorporated herein by reference in its entirety; U.S. Patent No. 5,073,372 [Turner et al., Issued December 17, 1991]; U.S. Patent No. 5,073,371 [Turner et al., Issued December 17, 1991]; And Segarin et al., Cosmetics Science and Technology, VIII chapter, p. 189 < / RTI > Non-limiting examples of sunscreen agents useful in the compositions of the present invention include 2-ethylhexyl p -methoxy cinnamate, 2-ethylhexyl N, N-dimethyl- p- aminobenzoate, p- aminobenzoic acid, Methoxy-t-butyldibenzoylmethane, 4-isopropyldibenzoylmethane, 3- (4-methoxyphenyl) benzoylmethane, 3- There are those selected from the group consisting of benzylidene camphor, 3- (4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, and mixtures thereof. Other useful sunscreen agents include U.S. Patent No. 4,937,370 [Sabatelli, issued June 26, 1990]; And U.S. Patent No. 4,999,186 (Sabatelli et al., Issued March 12, 1991), both of which are incorporated herein by reference in their entirety. Particularly preferred examples of such sunscreen agents include 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of 2,4-dihydroxybenzophenone, 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester, 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester, 4- (2-ethylhexyl) 4-N, N- (2-ethylhexyl) -methylaminobenzoic acid ester of dibenzoylmethane and dibenzoylmethane, and mixtures thereof. The exact amount of sunscreen agent that can be used will depend on the sunscreen chosen and the sunscreen desired to be achieved (SPF). SPF is a commonly used light protection measure of sunscreen for erythema. Which is incorporated herein by reference in its entirety [ Federal Register , Vol. 43, No. 166, pp. 38206 to 38269, August 25, 1978].

Hydrocolloid

Hydrocolloids may also optionally be included in the article of the present invention. Hydrocolloids are well known in the art and aid in extending the useful life of the surfactants contained within the cleansing components of the present invention so that the article can last for at least one full shower or bath. Suitable hydrocolloids include xanthan gum, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl and ethyl cellulose, natural gums, gudras guar gum, bean gum, natural starch, deionized starch Starch octenyl succinate), and the like, but are not limited thereto.

Pyrogenic zeolite

Zeolites and other compounds which exothermally react when combined with water may also optionally be included in the article of the present invention.

Structured Conditioning Agents

The article of the present invention may optionally contain a structured conditioning agent. Suitable structured conditioning agents include, but are not limited to, vesicular structures such as ceramides, liposomes, and the like.

Hydrogel-forming polymeric gelling agent

In certain embodiments of the present invention, the article may optionally contain an aqueous gel, or " hydrogel, " formed from a hydrogel-forming polymeric gellant and water. More specifically, the hydrogel is contained within the cleansing component or therapeutic efficacy component of the article. In the presence of the aqueous gel, the article is preferably present in an amount of from about 0.1% to about 100% by weight, more preferably from about 3% to about 50% by weight, most preferably from about 5% 35% by weight of a hydrogel-forming polymeric gellant based on the dry weight of the hydrogel-forming polymeric gellant.

Generally, the hydrogel-forming polymeric gellant material of the present invention is an at least partially crosslinked polymer made from a polymerizable unsaturated acid-containing monomer which is water-soluble or water-soluble at the time of hydrolysis. This includes monoethylenically unsaturated compounds having at least one hydrophilic radical, including, but not limited to, olefinically unsaturated acids and anhydrides comprising at least one carbon-carbon olefinic double bond. In these monomers, Water solubility means that the monomer is dissolved in deionized water at a level of at least 0.2%, preferably at least 1.0% at 25 ° C.

In polymerization, the monomeric units as mentioned above generally contain from about 25 mol% to 99.99 mol%, more preferably from about 50 mol% to 99.99 mol%, most preferably at least about 75 mol% of the polymeric gellant material Phosphorus (based on the dry weight of the polymer), and acid-containing monomers.

Wherein the hydrogel-forming polymeric gellant is preferably partially crosslinked to an extent that the resulting polymer is sufficiently high that it does not exhibit a glass transition temperature (Tg) of less than about 140 캜, and therefore, A " hydrogel-forming polymeric gellant " will refer to a polymer that satisfies these parameters. Preferably, the hydrogel-forming polymeric gellant has no Tg at less than about 180 DEG C, more preferably no Tg at temperatures above about 300 DEG C prior to decomposition of the polymer. The Tg can be measured by differential scanning calorimetry (DSC) using a sample of 5 mg or less at a heating rate of 20.0 DEG C / min. Tg is calculated as the midpoint between the start point and the end point of the heat flow change corresponding to the glass transition on the DSC heat capacity heating curve. The use of DSC to determine Tg is well known in the art, see [B. Cassel and MP DiVito, " Use of DSC To Obtain Accurate Thermodynamic and Kinetic Data ", American Laboratory, January 1994, pp. 14-19; Wunderlich, Thermal Analysis , Academic Press, Inc., 1990).

The hydrogel-forming polymeric material is characterized as a highly absorbent and can retain water in an absorbed or " gel " state. The preferred hydrogel-forming polymeric gellant herein is capable of absorbing at least about 40 grams, preferably at least about 60 grams per gram, more preferably at least about 80 grams per gram of water (deionized water) per gram of gelling agent There will be. These values, referred to herein as " absorbent capacity ", can be measured according to the procedure in the absorbent capacity " tea bag " test described above.

Wherein the hydrogel-forming polymeric gellant will generally be at least partially crosslinked. Suitable crosslinking agents are well known in the art and include, for example, (1) compounds having two or more polymerizable double bonds; (2) a compound having at least one polymerizable double bond and at least one functional group reactive with an acid-containing monomer material; (3) a compound having at least two functional groups which are reactive with an acid-containing monomer material; And (4) a polyvalent metal compound capable of forming an ionic crosslinked portion.

Crosslinking agents having two or more polymerizable double bonds include (i) di- or polyvinyl compounds such as divinylbenzene and divinyltoluene; (ii) a di- or triacrylate ester of a polyol such as, for example, ethylene glycol, trimethylol propane, glycerine, or polyoxyethylene glycol, and a di- or polyester of an unsaturated mono- or polycarboxylic acid ; (iii) bisacrylamides such as N, N-methylenebisacrylamide; (iv) a carbamyl ester which can be obtained by reacting a polyisocyanate with a hydroxyl group-containing monomer; (v) di- or polyallyl ethers of polyols; (vi) di- or polyallyl esters of polycarboxylic acids such as diallyl phthalate, diallyl adipate and the like; (vii) esters of monoallyl esters of polyols with unsaturated mono- or polycarboxylic acids, such as acrylic acid esters of polyethylene glycol monoallyl ether; And (viii) di- or triallylamine.

Crosslinking agents having at least one polymerizable double bond and at least one functional group reactive with the acid-containing monomer material include N-methylol acrylamide, glycidyl acrylate, and the like. Suitable crosslinking agents having two or more functional groups reactive with the acid-containing monomeric material include glyoxal; Polyols such as ethylene glycol and glycerol; Polyamines such as alkylenediamines (e.g., ethylenediamine), polyalkylene polyamines, polyepoxides, di- or polyglycidyl ethers, and the like. Suitable polyvalent metal bridging agents capable of forming ionic bridges include, for example, oxides, hydroxides and weak acid salts of alkaline earth metals (e.g., calcium, magnesium) and zinc, including calcium oxide and zinc diacetate , Carbonates, acetates, etc.).

Many of the above-described types of crosslinking agents are described in more detail in U.S. Patent No. 4,076,663 (Masuda et al., Issued Feb. 28, 1978) and U.S. Patent No. 4,861,539 (Allen et al., Issued Aug. 29, 1989) , Both of which are incorporated herein by reference. Preferred crosslinking agents include di- or polyesters of unsaturated mono- or polycarboxylic acid monoallyl esters of polyols, bisacrylamides, and di- or triallyl amines. Specific examples of particularly preferable crosslinking agents include N, N'-methylenebisacrylamide and trimethylolpropane triacrylate.

The cross-linking agent will generally comprise from about 0.001 mole percent to about 5 mole percent of the resulting hydrogel-forming polymeric material. More generally, the cross-linking agent will comprise from about 0.01 mole percent to about 3 mole percent of the hydrogel-forming polymeric gellant used.

Wherein the hydrogel-forming polymeric gellant can be used in a partially neutralized form. For purposes of the present invention, such a material is considered to be partially neutralized when at least 25 mole%, preferably at least 50 mole%, of the monomers used for polymer formation are neutralized acid group-containing monomers that are neutralized with a base . Suitable neutralizing base cations include alkali and alkaline earth metal hydroxides (e.g., KOH, NaOH), ammonium, substituted ammonium, and amino alcohols such as 2-amino- Amine, and 2-amino-2-methyl-1-propanol). The percentage of total monomers used, which are neutralized acid group containing monomers, is referred to herein as " neutralization degree ". The degree of neutralization will preferably not exceed 98%.

Suitable hydrogel-forming polymeric gellants for use herein are well known in the art and include, for example, U.S. Pat. No. 4,076,663 [Masuda et al., Issued Feb. 28, 1978]; U.S. Patent No. 4,062,817 [Westerman, issued December 13, 1977]; U.S. Patent No. 4,286,082 [Tsubakimoto et al., Issued Aug. 25, 1981]; U.S. Patent No. 5,061,259 [Goldman et al., Issued October 29, 1991]; And U.S. Patent No. 4,654,039 [Brandt et al., Issued March 31, 1987], each of which is incorporated herein by reference in its entirety.

Suitable hydrogel-forming polymeric gellants for use herein are also described in U.S. Patent No. 4,731,067 [Le-Khac, issued March 15, 1988], U.S. Patent No. 4,743,244 [Le-Khac, May 10, 1988 U.S. Patent No. 4,813,945 [Le-Khac, issued March 21, 1989], U.S. Patent No. 4,880,868 [Le-Khac, issued November 14, 1989], U.S. Patent No. 4,892,533 [Le-Khac, U.S. Patent No. 5,026,784 [Le-Khac, issued June 25, 1991], U.S. Patent No. 5,079,306 [Le-Khac, issued January 7, 1992] U.S. Patent No. 4,861,539 [Allen, Farrer, and Flesher, issued Aug. 29, 1989], and U.S. Patent No. 4,962,172 [Allen, Farrer, et al. Flesher, Oct. 9, 1990, each of which is incorporated herein by reference in its entirety.

Suitable hydrogel-forming polymeric gellants in particulate form are commercially available from Hoechst Celanese Corporation (Portsmouth, VA, USA) (Sanwet ^TM superabsorbent polymer), Nippon Shokubai, Japan (Aqualic ^TM such as L-75, And Dow Chemical Company (Midland, MI, USA) (Dry Tech ^TM ).

Hydrogel-forming polymeric gellants in the form of fibers are commercially available from Camelot Technologies Inc. (Leominster, MA, USA) (Fibersorb ^TM , such as SA 7200H, SA 7200M, SA 7000L, SA 7000, and SA 7300).

The article of the present invention may also contain other hydrophilic gelling agents. These include carboxylic acid-containing polymers such as those described above, as well as a variety of other water-soluble or colloidal water-soluble polymers such as cellulose ethers (e.g., hydroxyethyl cellulose, methylcellulose, Hydroxypropyl methylcellulose), polyvinylpyrrolidone, polyvinyl alcohol, guar gum, hydroxypropyl guar gum and xanthan gum. Among these additional hydrophilic gelling agents, preferred are acid-containing polymers, especially carboxylic acid-containing polymers. Particularly preferred are water-soluble polymers of crosslinked acrylic acid with polyalkenyl polyethers of polyhydric alcohols, and optionally acrylate esters or polyfunctional vinylidene monomers.

Preferred copolymers useful in the present invention comprise from 95% to 99% by weight of an olefinically unsaturated carboxylic monomer selected from the group consisting of acrylic acid, methacrylic acid and ethacrylic acid; From about 1% to about 3.5% by weight of an acrylate ester of the formula:

(Wherein R is an alkyl radical having 10 to 30 carbon atoms, and R < ₁ > is hydrogen, methyl or ethyl); And a polymerizable crosslinked polyalkenyl polyether of a polyhydric alcohol containing at least one alkenyl ether group per molecule (the parent polyhydric alcohol containing at least 3 carbon atoms and at least 3 hydroxyl groups) in an amount of from 0.1% to 0.6% By weight based on the total weight of the composition.

Preferably, these polymers contains an acrylate ester of about 96% to acrylic acid and from about 2.5% to about 3.5% by weight to approximately 97.9% by weight, where the alkyl group has carbon atoms of 12 to 22, R ₁ is methyl And most preferably, the acrylate ester is stearyl methacrylate. Preferably, the amount of crosslinked polyalkenyl polyether monomer is from about 0.2% to 0.4% by weight. Preferred crosslinked polyalkenyl polyether monomers are allylpentaerythritol, trimethylolpropane diallyl ether, or allyl sucrose. These polymers are described in detail in U.S. Patent No. 4,509,949 [Huang et al., Issued April 5, 1985], which is incorporated herein by reference.

Another preferred copolymer useful in the present invention is a polymer containing two or more monomeric components, one of which is a monomeric olefinically unsaturated carboxylic acid and the other is a polyalkenyl, polyether of a polyhydric alcohol. If desired, additional monomeric materials may be present in the monomeric mixture, even in predominant proportions.

The first monomeric component useful in the preparation of said polymeric polymer is an olefinically unsaturated carboxylic acid containing at least one activated carbon-carbon olefinic double bond and at least one carboxyl group. Preferred carboxyl monomers are acrylic acids having the following general formula:

(Wherein R ² is a substituent selected from the group consisting of hydrogen, halogen, and a cyanogen (-C═N) group, a monovalent alkyl radical, a monovalent alkaryl radical, and a monovalent alicyclic radical. , Acrylic acid, methacrylic acid, and ethacrylic acid are most preferable. Another useful carboxyl monomer is maleic anhydride or maleic acid. The amount of acid used will be from about 95.5 wt.% To about 98.9 wt.%.

A second monomeric component useful in the preparation of these carboxylic polymers is a monomeric component in which the olefinic double bond has more than one alkenyl ether group per molecule, such as an alkenyl group present attached to the terminal methylene group CH ₂ = C < Polyalkenyl polyether.

With additional monomeric materials which may be present in the polymers, such as butadiene, isoprene, divinyl benzene, divinyl naphthalene, including allyl acrylate, and the like, at least two terminal CH ₂ <polyfunctional vinylidene monomer containing a group . Such polymers are described in greater detail in U.S. Patent No. 2,798,053 [Brown, 2 July 1957], which is incorporated herein by reference in its entirety.

Examples of carboxylic acid copolymers useful in the present invention include Carbomer 934, Carbomer 941, Carbomer 950, Carbomer 951, Carbomer 954, Carbomer 980, Carbomer 981, Carbomer 1342, Acrylate / C10-30 alkyl acrylate cross- (Carbopol 934, Carbopol 941, Carbopol 950, Carbopol 951, Carbopol 954, Carbopol 980, Carbopol 981, Carbopol 1342, and Pemulen series, each available from BF Goodrich).

Other carboxylic acid copolymers useful in the present invention include sodium salts of acrylic acid / acrylamide copolymers sold by the Hoechst Celanese Corporation under the tradename Hostaceren PN73. Also included are hydrogel polymers sold by Lipo Chemicals Inc. under the trade name HYPAN hydrogel. These hydrogels consist of crystalline flicks of nitrate on the C-C main chain with various other pendant groups such as carboxyl, amide, and amidine. An example of this would include HYPAN SA 100 H, a polymer powder available from Lipo Chemical.

The neutralizing agents used to neutralize the acid groups of these polymers include those described above

Hydrophobic conditioning agent

The article of the present invention may contain one or more hydrophobic conditioning agents useful for imparting a conditioning effect to the skin or hair during use of the article. The article of the present invention is preferably present in an amount of from about 0.5% to about 1,000%, more preferably from about 1% to about 200%, and most preferably from about 25% to about 100% % Of a hydrophobic conditioning agent.

The hydrophobic conditioning agent may be selected from one or more hydrophobic conditioning agents such that the weighted arithmetic mean solubility parameter of the hydrophobic conditioning agent is less than or equal to 10.5. Based on the mathematical definition of the solubility parameter, for example, for a hydrophobic conditioning agent containing two or more compounds, even if the individual solubility parameter of one of the compounds is greater than 10.5, the desired weighted arithmetic mean solubility parameter, i.e., 10.5 It is possible to achieve the following.

Solubility parameters are well known to those of skill in the art of formulation and are routinely used as a guide to determine the miscibility and solubility of materials within a formulation process.

The solubility parameter, delta, of a chemical compound is defined as the square root of the cohesive energy density of the compound. Typically, the solubility parameter of a compound is calculated from the tabulated values of the molar volume and the adduct contribution to the heat of vaporization of the components of the compound using the following equation:

(Where Σ _i E _i = sum of contributions of vapor-phase heat additions and Σ _i m _i = sum of molar volume anomalies).

Standards of volatilization heat and molar volume contribution to a wide variety of atom and atomic groups are described in Barton, AFM Handbook of Solubility Parameters , CRC Press, Chapter 6, Table 3, pp. 64-66 (1985). The solubility parameter formulas are described in detail in Fedors, RF, " A Method for Estimating Both Solubility Parameters and Molar Volumes of Liquids &quot;, Polymer Engineering and Science , vol. 14, no. 2, pp. 147 to 154 (February 1974).

The solubility parameter follows a mixture law that the solubility parameter for a mixture of materials is given by the weighted arithmetic mean (i.e., weighted average) of the solubility parameter for each component of the mixture. Quot ; Handbook of Chemistry and Physics , &lt; RTI ID = 0.0 &gt; 57th Edition, CRC Press, p. C-726 (1976-1977).

Formulation chemists typically report solubility parameters in units of (cal / cm 3) ^1/2 and report. In the [ Handbook of Solubility Parameters] tabulated values for the contribution of vaporization heat are reported in kJ / mol. However, these tabulated vaporization heat values are readily converted to cal / mol using the well-known correlation: &lt; RTI ID = 0.0 &gt;

1 J / mol = 0.239006 cal / mol and 1000 J = 1 kJ

(Gordon, AJ et al., The Chemist's Companion , John Wiley & Sons, pp. 456 ~ 463 (1972).

In addition, the solubility parameters for a wide variety of chemicals are tabulated. Preparation of a table of solubility parameters is shown in the cited Handbook of Solubility Parameters . See also " Solubility Effects In Product, Package, Penetration, And Preservation &quot;, CD Vaughan, Cosmetics and Toiletries , vol. 103, October 1988, pp. 47 ~ 69].

Non-limiting examples of hydrophobic conditioning agents include mineral oil, petrolatum, lecithin, hydrogenated lecithin, lanolin, lanolin derivatives, C7 to C40 branched chain hydrocarbons, C1 to C30 alcohol esters of C1 to C30 carboxylic acids, C2 A C1 to C30 alcohol ester of a C30 dicarboxylic acid, a monoglyceride of a C1 to C30 carboxylic acid, a diglyceride of a C1 to C30 carboxylic acid, a triglyceride of a C1 to C30 carboxylic acid, Ethylene glycol diesters of C1 to C30 carboxylic acids, propylene glycol monoesters of C1 to C30 carboxylic acids, propylene glycol diesters of C1 to C30 carboxylic acids, C1 to C30 carboxylic acid monoesters of sugars, Polydialkylsiloxane, polyalkarylsiloxane, cyclomethicone having 3 to 9 silicon atoms, vegetable oil, hydrogenated vegetable oil, polypropylene glycol C4- C20 alkyl ethers, di C8-C30 alkyl ethers, and combinations thereof.

Mineral oil, also known as petrolatum liquid, is a mixture of liquid hydrocarbons obtained from petroleum. The Merck Index, 10th ed., 7048, p. 1033 (1983) and International Cosmetic Ingredient Dictionary, 5th edition, vol. 1, p. 415-417 (1993).

Petrolatum, also known as petroleum jelly, is a colloidal system of non-linear solid hydrocarbons and high boiling liquid hydrocarbons, most of which are contained within micelles. Which are incorporated herein by reference in their entirety, The Merck Index, 10th ed., 7047, p. 1033 (1983); [Schindler, Drug. Cosmet. Ind. , 89 , 36-37, 76, 78-80, 82 (1961)]; And International Cosmetic Ingredient Dictionary, 5th Edition, vol. 1, p. 537 (1993).

Lecithin is also useful as a hydrophobic conditioning agent. It is a naturally occurring mixture of diglycerides of certain fatty acids linked to a choline ester of phosphoric acid.

Straight chain and branched chain hydrocarbons having about 7 to about 40 carbon atoms are useful herein. Non-limiting examples of these hydrocarbon materials include dodecane, isododecane, squalane, cholesterol, hydrogenated polyisobutylene, docosane acid (i.e., C ₂₂ hydrocarbon), hexadecane, iso-hexadecane (Presperse (South Plainfield, NJ Material ) In Permethyl &Lt; RTI ID = 0.0 &gt; 101A &lt; / RTI &gt; C7-C40 isoparaffins, C7-C40 branched hydrocarbons, are also useful. Polydecene, a branched liquid hydrocarbon, is also useful here, which is available from Mobile Chemical (Edison, NJ) under the trade name Puresyn 100 And Puresyn 3000 .

Also useful are C1 to C30 carboxylic acids and C1 to C30 alcohol esters of C2 to C30 dicarboxylic acids, including straight and branched chain materials as well as aromatic derivatives. It is also possible to use monoglycerides of C1 to C30 carboxylic acids, diglycerides of C1 to C30 carboxylic acids, triglycerides of C1 to C30 carboxylic acids, ethylene glycol monoesters of C1 to C30 carboxylic acids, Esters such as ethylene glycol diesters, propylene glycol monoesters of C1 to C30 carboxylic acids, and propylene glycol diesters of C1 to C30 carboxylic acids are also useful. Also included are straight chain, branched chain and aryl carboxylic acids. Propoxylated and ethoxylated derivatives of these materials are also useful. Non-limiting examples include diisopropyl sebacate, diisopropyl adipate, isopropyl myristate, isopropyl palmitate, myristyl propionate, ethylene glycol distearate, 2-ethylhexyl palmitate, isodecyl neopenta Maleic anhydride, di-2-ethylhexyl maleate, cetyl palmitate, myristyl myristate, stearyl stearate, cetyl stearate, behenyl behenate, dioctyl maleate, dioctyl sebacate, diisopropyl adipate , Cetyl octanoate, diisopropyldrinoleate, caprylic / capric acid triglyceride, PEG-6 caprylic / capric acid triglyceride, PEG-8 caprylic / capric acid triglyceride, and combinations thereof Water is included.

Various C1 to C30 monoesters and polyesters of sugars and related substances are also useful. The ester is derived from a sugar or polyol moiety and at least one carboxylic acid moiety. Depending on its constituent acid and sugar, the ester may be in the form of a liquid or solid at room temperature. Examples of liquid esters include: glucose tetraoleate, glucose tetraester of soybean oil fatty acid (unsaturated), mannosetetraester of mixed soybean oil fatty acid, galactose tetraester of oleic acid, arabinose tetraester of linoleic acid, xylostetryri Polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, nylate, galactose pentaoleate, sorbitol tetraoleate, sorbitol hexaester of unsaturated soybean oil fatty acid, xylitol pentaoleate, sucrose tetraoleate, sucrose pentaoleate, sucrose hexaoleate, , Sucrose octaoleate, and mixtures thereof. Examples of solid esters include: sorbitol hexaester in which the carboxylic acid ester moiety is palmitoleate and arachidate in a 1: 2 molar ratio; Octaesters of raffinose wherein the carboxylic acid ester moiety is linoleate and behenate in a 1: 3 molar ratio; A hepta ester of maltose in which the esterified carboxylic acid moiety is a sunflower seed oil fatty acid and lignocerate in a 3: 4 molar ratio; Octaesters of sucrose wherein the esterified carboxylic acid moiety is an oleate of 2: 6 molar ratio and behenate; And an octaester of sucrose wherein the esterified carboxylic acid moiety is laurate, linoleate and behenate in a 1: 3: 4 molar ratio. Preferred solid materials are sucrose polyesters, C18 mono- and / or di-unsaturated and behenic, with a degree of esterification of 7 to 8 and a fatty acid moiety with a molar ratio of unsaturated: behenic moiety of 1: 7 to 3: 5. Particularly preferred solid sugar polyesters are sucrose octaesters having about 7 beef fatty acid moieties and about 1 oleic acid moiety in the molecule. Other substances include sucrose cottonseed oil or soybean oil fatty acid esters. The ester materials are described in U.S. Patent No. 2,831,854, U.S. Patent No. 4,005,196 [Jandacek, issued January 25, 1977], each of which is incorporated herein by reference in its entirety; U.S. Patent No. 4,005,195 [Jandacek, issued January 25, 1977], U.S. Patent No. 5,306,516 [Letton et al., Issued April 26, 1994]; U.S. Patent No. 5,306,515 [Letton et al., Issued April 26, 1994]; U.S. Patent No. 5,305,514 [Letton et al., Issued April 26, 1994]; U.S. Patent No. 4,797,300 [Jandacek et al., Issued January 10, 1989]; U.S. Patent No. 3,963,699 [Rizzi et al., Issued June 15, 1976]; U.S. Patent No. 4,518,772 [Volpenhein, issued May 21, 1985]; And U.S. Patent No. 4,517,360 [Volpenhein, issued May 21, 1985].

Non-volatile silicones such as polydialkylsiloxanes, polydialylsiloxanes, and polyalkarylsiloxanes are also useful oils. These silicones are described in U.S. Pat. No. 5,069,897 [Orr, 3 December 1991], which is hereby incorporated by reference in its entirety. The polyalkylsiloxane corresponds to the general formula R ₃ SiO [R ₂ SiO] _x SiR ₃ , wherein R is an alkyl group (preferably R is methyl or ethyl, more preferably methyl) Lt; RTI ID = 0.0 &gt; 500 &lt; / RTI &gt; Commercially available polyalkylsiloxanes include polydimethylsiloxanes, also known as dimethicone; Non-limiting examples thereof include Vicasil Series (General Electric Company sales), and Dow Corning 200 series (sold by Dow Corning Corporation). Specific examples of useful polydimethylsiloxanes herein include Dow Corning, having a viscosity of 10 centistoke and a boiling point of greater than 200 &lt; RTI ID = 0.0 &gt; 225 fluid, and a viscosity of 50,350, and 12,500 centistokes, respectively, and a boiling point greater than 200 &lt; 0 & 200 fluid. Also provided is a polymeric material corresponding to the general formula [(CH ₂ ) ₃ SiO _1/2 ] _x [SiO ₂ ] _{y wherein} x is an integer from about 1 to about 500, y is from about 1 to about 500 Lt; / RTI &gt; is an integer). Also useful are materials such as trimethylsiloxysilicate. Commercially available trimethylsiloxysilicates are commercially available from Dow Corning, a mixture with dimethicone, 593 fluid. Dimethicol, a hydroxy-terminated dimethyl silicone, is also useful herein. These materials can be represented by the general formulas R ₃ SiO [R ₂ SiO] _x SiR ₂ OH and HOR ₂ SiO [R ₂ SiO] _x SiR ₂ OH (wherein R is an alkyl group Ethyl, more preferably methyl), and x is an integer of about 500 or less selected to achieve the desired molecular weight. Commercially available dimethiconols are typically sold as a mixture with dimethicone or cyclomethicone (see, e.g., Dow Corning 1401, 1402, and 1403 fluids). Polyalkylarylsiloxanes are also useful herein and are preferably polymethylphenylsiloxanes having a viscosity of about 15 to about 65 centistokes at 25 캜. These materials are available, for example, as SF 1075 methylphenyl fluids (sold by General Electric Company) and 556 cosmetic grade phenyl trimethicone fluids (sold by Dow Corning Corporation). Alkylated silicones such as methyldecylsilicon and methyloctylsilicon are also useful herein and are commercially available from General Electric Company. Also useful are alkyl modified siloxanes such as alkyl methicone and alkyl dimethicone wherein the alkyl chain contains from 10 to 50 carbons. These siloxanes are commercially available under the trade names ABIL WAX 9810 (C ₂₄ -C ₂₈ alkylmethicone) (sold by Goldschmidt) and SF 1632 (cetearyl methicone) sold by General Electric Company.

Vegetable oils and hydrogenated vegetable oils are also useful herein. Examples of vegetable oils and hydrogenated vegetable oils include safflower oil, castor oil, coconut oil, cottonseed oil, menhaden oil, palm kernel oil, palm oil, peanut oil, soybean oil, rapeseed oil, flaxseed oil, , Hydrogenated coconut oil, hydrogenated cottonseed oil, hydrogenated chenille oil, hydrogenated coconut oil, hydrogenated palm oil, hydrogenated peanut oil, hydrogenated soybean oil, hydrogenated rapeseed oil, hydrogenated coconut oil, hydrogenated coconut oil, hydrogenated coconut oil, hydrogenated coconut oil, hydrogenated coconut oil, Hydrogenated flaxseed oil, hydrogenated unsweetened oil, hydrogenated sesame oil, hydrogenated sunflower seed oil, and mixtures thereof.

C4-C20 alkyl ethers of polypropylene glycol, C1-C20 carboxylic acid esters of polypropylene glycol, and di-C8-C30 alkyl ethers are also useful herein. Non-limiting examples of these materials include PPG-14 butyl ether, PPG-15 stearyl ether, dioctyl ether, dodecyl octyl ether, and mixtures thereof.

Hydrophilic conditioning agent

The article of the present invention may optionally contain one or more hydrophilic conditioning agents. Non-limiting examples of hydrophilic conditioning agents include polyhydric alcohols, polypropylene glycols, polyethylene glycols, ureas, pyrrolidonecarboxylic acids, ethoxylated and / or propoxylated C3 to C6 diols and triols, alpha-hydroxy C2- C6 carboxylic acid, an ethoxylated and / or propoxylated sugar, a polyacrylic acid copolymer, a sugar having a carbon number of about 12 or less, a sugar alcohol having a carbon number of about 12 or less, and a mixture thereof. Specific examples of useful hydrophilic conditioning agents include urea; Guanidine; Glycolic acid and glycolate salts such as ammonium and quaternary alkylammonium; Lactic acid and lactate salts (e.g., ammonium and quaternary alkylammonium); Sucrose, fructose, glucose, erroitol, erythritol, sorbitol, mannitol, glycerol, hexanetriol, propylene glycol, butylene glycol, hexylene glycol and the like; 15, PPG-17, PPG-20, PPG-26, PPG-30, PPG-9, PPG-12, PEG- Polypropylene glycols such as 34; Alkoxylated glucose; Hyaluronic acid; Cationic skin conditioning polymers (e.g., quaternary ammonium polymers such as polyquaternium polymers); And mixtures thereof. In particular, glycerol is the preferred hydrophilic conditioning agent in the articles of the present invention. In addition, various optional forms of aloe vera (e.g., aloe vera gel), chitosan and chitosan derivatives such as chitosan lactate, lactam monoethanolamine; Acetamide monoethanolamine; And mixtures thereof are also useful. Also useful are propoxylated glycerol as described in the propoxylated glycerol described in U.S. Patent No. 4,976,953 (Orr et al., Issued December 11, 1990), which is hereby incorporated by reference in its entirety.

In the case where the therapeutic agent does not contain the conditioning agent, the active ingredient may be included in various forms in addition to the coacervate formed when the article is exposed to water. In one embodiment of the invention, the conditioning agent is in the form of an emulsion. For example, water-in-oil, water-in-oil, water-in-oil, and silicone-in-water oil-in-water emulsions are useful herein. As used in connection with emulsions, " water " may mean water-miscible agents such as water-soluble or glycerin as well as water.

In one embodiment, the conditioning agent comprises an emulsion further comprising an aqueous phase and an oil phase. As will be appreciated by those skilled in the art, a given component will be predominantly distributed within the water or oil phase depending on the water solubility / dispersibility of the therapeutic benefit agent in the composition. In one embodiment, the oil phase contains at least one hydrophobic conditioning agent. In another embodiment, the water phase contains one or more hydrophilic conditioning agents.

When the conditioning agent of the therapeutic agent is in the form of an emulsion, the emulsion generally contains an aqueous phase and an oily or lipid phase. Suitable oils or lipids may be derived from animals, plants or petroleum, and may be natural or synthetic (i.e., synthetic). Such oils are those discussed above in the section on hydrophobic conditioning agents. Additionally, preferred emulsions also contain a hydrophilic conditioning agent, such as glycerin, to allow glycerine-type emulsions in the oil to be produced.

The therapeutic efficacy component comprising the emulsion preferably further comprises from about 1% to about 10%, more preferably from about 2% to about 5%, by weight of the emulsifying agent, relative to the absence of therapeutic efficacy will be. The emulsifying agent may be nonionic, anionic or cationic. Suitable emulsions are described, for example, in U.S. Patent No. 3,755,560 [Dickert et al., Issued Aug. 28, 1973]; U.S. Patent No. 4,421,769 [Dixon et al., Issued December 20, 1983]; And McCutcheon ' s Detergents and Emulsifiers , North American Edition, pp. 317-324 (1986). In addition, the absence of therapeutic efficacy in the form of an emulsion may contain a defoamer to minimize foaming upon application to the skin. Defoamers include high molecular weight silicones and other materials well known in the art for this purpose.

The absence of therapeutic efficacy may also be in the form of a microemulsion. As used herein, " microemulsion " refers to a thermodynamically stable mixture of two immiscible solvents (one non-polar and one polar) stabilized by a surfactant that is an amphiphilic molecule. Preferred microemulsions include water-in-oil microemulsions.

Cleansing ingredient

The article of the present invention may optionally contain a cleansing component that additionally contains one or more surfactants. The cleansing component is disposed adjacent to the nonwoven layer of the water-insoluble substrate. The articles of the invention contain from about 10% to about 1,000%, preferably from about 50% to about 600%, more preferably from about 100% to about 250%, of a surfactant, based on the weight of the water-insoluble substrate. In addition, the articles of the present invention preferably contain at least about 1 g of surfactant based on the weight of the water-insoluble substrate. Thus, the cleansing component can be added to the substrate without the need for a drying process.

The surfactant of the cleansing component is preferably a foam-forming surfactant. As used herein, " lathering surfactant " refers to a surfactant that, when combined with water to produce a foam or lather when mechanically stirred. Since the increased bubbles are important to consumers as an indication of the cleansing effect, the surfactants are preferred. In certain embodiments, the combination of surfactant or surfactant is mild. As used herein, the expression " mild " means that the article of the present invention, as well as the surfactant, will comprise at least, typically, a natural soap and a synthetic surfactant (e. And Zest Quot;) &lt; / RTI &gt; of the conventional bar soap matrix. Methods for measuring the purity or reversibility of surfactant-containing articles are based on skin barrier breakdown tests. In this test, the smoother the surfactant, the less skin barrier is destroyed. Skin barrier breakdown is measured by the relative amount of radiation-labeled (tritium-labeled) water (3H-H ₂ O) flowing from the test solution through the skin epidermis into the physiological buffer contained in the dialysis chamber. The test is described in TJ Franz, J. Invest. Dermatol. , 1975, 64, pp. 190-195; And U.S. Patent No. 4,673,525 [Small et al., Issued June 16, 1987]. Other test methods known to those skilled in the art for measuring the purity of a surfactant can also be used.

A wide variety of foam-forming surfactants are useful in the present invention and are selected from the group consisting of anionic foam forming surfactants, nonionic foam forming surfactants, cationic foam forming surfactants, amphoteric foam forming surfactants, and mixtures thereof &Lt; / RTI &gt;

Anionic foaming surfactant

Non-limiting examples of anionic foaming surfactants useful in compositions of the present invention are described in McCutcheon's, Detergents and Emulsifiers , North American edition (1986), published by Allured Publishing Corporation; McCutcheon ' s, Functional Materials , North American edition (1992); And U.S. Patent No. 3,929,678 [Laughlin et al., Issued December 30, 1975], all of which are incorporated herein by reference in their entirety.

A wide variety of anionic surfactants are useful herein. Non-limiting examples of anionic foaming surfactants include alkyl and alkyl ether sulfates, sulfated monoglycerides, sulfonated olefins, alkylaryl sulfonates, primary or secondary alkanesulfonates, alkyl sulfosuccinates, Acyl isocyanate, acylated peptide, alkyl ether carboxylate, acyl lactyl ester, acyl glyceryl ether sulfonate, sulfonated methyl ester, sulfonated fatty acid, alkyl phosphate, acyl glutamate, acyl sarcosinate, A surfactant, an anionic surfactant, an anionic surfactant, and combinations thereof. Combinations of anionic surfactants can be used effectively in the present invention.

Anionic surfactants used in the cleansing component include alkyl and alkyl ether sulfates. Wherein the materials each have the formula R ¹ O-SO ₃ M and R ¹ (CH ₂ H ₄ O) _x -O-SO ₃ M wherein R ¹ is a saturated or unsaturated, branched or unbranched carbon number of from about 8 to about X is an integer from 1 to 10 and M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. The alkyl sulfates are typically prepared by sulfation of monohydric alcohols (from about 8 to about 24 carbon atoms) using sulfur trioxide, or other known sulfation techniques. The alkyl ether sulfates are typically prepared by sulfating the condensation products of ethylene oxide and monohydric alcohols (about 8 to about 24 carbon atoms). These alcohols can be derived or synthesized from fats, such as coconut oil or tallow. Specific examples of alkyl sulfates that can be used in the cleansing component include sodium, ammonium, potassium, magnesium or TEA salts of lauryl or myristyl sulfate. Examples of alkyl ether sulfates that may be used include ammonium, sodium, magnesium, or TEA laureth-3 sulfate.

Another suitable class of anionic surfactants are the sulfated monoglycerides in the form of R ¹ CO-O-CH ₂ -C (OH) H-CH ₂ -O-SO ₃ M wherein R ¹ is Saturated or unsaturated, branched or unbranched alkyl group having from about 8 to about 24 carbon atoms and M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine, and monoethanolamine. They are typically prepared by the reaction of glycerin with a fatty acid (about 8 to about 24 carbon atoms) to form a monoglyceride followed by sulfating the monoglyceride with sulfur trioxide. An example of a sulfated monoglyceride is sodium coco monoglyceride sulfate.

Other suitable anionic surfactants include olefin sulfonates in the form of R ¹ SO ₃ M wherein R ¹ is a monoolefin having from about 12 to about 24 carbon atoms and M is selected from the group consisting of ammonium, sodium, potassium, magnesium, triethanolamine, di Such as ethanolamine and monoethanolamine. These compounds are prepared by sulfonating alpha olefins using uncomplexed sulfur trioxide and then neutralizing the acid reaction mixture under conditions such that all the sultones formed during the reaction are hydrolyzed to produce the corresponding hydroxyalkanesulfonate . An example of a sulfonated olefin is sodium C14 / C16 alpha olefin sulphonate.

Other suitable anionic surfactants include linear alkylbenzenesulfonates in the form of R ¹ -C ₆ H ₄ -SO ₃ M wherein R ¹ is a saturated or unsaturated, branched or unbranched alkyl group of about 8 to about 24 carbon atoms , And M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. These are formed by sulfonating linear alkylbenzenes with sulfur trioxide. An example of such anionic surfactant is sodium dodecylbenzenesulfonate.

Other anionic surfactants suitable for cleansing ingredients include primary or secondary alkanesulfonates in the form of R ¹ SO ₃ M wherein R ¹ is a saturated or unsaturated, branched or unbranched alkyl chain having from about 8 to about 24 carbon atoms And M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. These are generally formed by sulfonation of paraffins using sulfur dioxide in the presence of chlorine and ultraviolet radiation, or by other known sulfonation methods. The sulfonation can occur at the secondary or primary position of the alkyl chain. Examples of alkanesulfonates useful herein include alkali metal or ammonium C13 to C17 paraffin sulfonates.

Other suitable anionic surfactants include alkylsulfosuccinates, which include disodium N-octadecylsulfosuccinamate; Diammonium laurylsulfosuccinate; Tetrasodium N- (1,2-dicarboxyethyl) -N-octadecylsulfosuccinate; Diamyl esters of sodium sulfosuccinic acid; Dihexyl esters of sodium sulfosuccinic acid; And dioctyl esters of sodium sulfosuccinic acid.

Taurine-based taurates, also known as 2-aminoethanesulfonic acid, are also useful. Examples of taurates include N-alkyltaurines such as those prepared by reacting dodecylamine with sodium isethionate, which is described in detail in U.S. Patent No. 2,658,072, which is incorporated herein by reference in its entirety. Other examples based on taurine include acyltaurine formed by reacting n-methyltaurine with a fatty acid (about 8 to about 24 carbon atoms).

Other classes of anionic surfactants suitable for use in cleansing compositions are acyl isethionates. The acyl isethionate typically has the formula R ¹ CO-O-CH ₂ CH ₂ SO ₃ M wherein R ¹ is a saturated or unsaturated, branched or unbranched alkyl group of about 10 to about 30 carbon atoms and M Is a cation. These are generally produced by reacting a fatty acid (about 8 to about 30 carbon atoms) with an alkali metal isethionate. Non-limiting examples of such acyl isethionates include ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate, and mixtures thereof.

Another suitable anionic surfactant is an alkyl glyceryl ether sulfonate in the form of R ¹ -OCH ₂ -C (OH) H-CH ₂ -SO ₃ M wherein R ¹ is a saturated or unsaturated, branched or unbranched, An alkyl group of from about 8 to about 24, and M is a water soluble cation such as ammonium, sodium, potassium, magnesium, triethanolamine, diethanolamine and monoethanolamine. These can be formed by reaction with epichlorohydrin and fatty alcohols of sodium bisulfite (about 8 to about 24 carbon atoms) or other known methods. As an example, there is sodium cocoglyceryl ether sulfonate.

Other suitable anionic surfactants include sulfonated fatty acids in the form of R ¹ -CH (SO ₄ ) -COOH and sulfonated methyl esters in the form of R ¹ -CH (SO ₄ ) -CO-O-CH ₃ , wherein R ¹ is a saturated or unsaturated, branched or unbranched alkyl group of about 8 to about 24 carbon atoms. They can be formed by sulfonation of fatty acids or alkyl methyl esters (about 8 to about 24 carbon atoms) with sulfur trioxide or by other known sulfonation techniques. Examples include alpha-sulfonated coconut fatty acids and lauryl methyl esters.

Other anionic materials include phosphates such as monoalkyl, dialkyl, and trialkyl phosphate salts produced by reaction of phosphorous pentoxide with branched or unbranched, monoalcohols of from about 8 to about 24 carbon atoms. They can also be produced by other known phosphorylation methods. An example of this class of surfactants is sodium mono or dilauryl phosphate.

Other anionic materials include acyl glutamates corresponding to the formula R ¹ CO-N (COOH) -CH ₂ CH ₂ -CO ₂ M, wherein R ¹ is a saturated or unsaturated, branched or unbranched, About 24 alkyl or alkenyl groups, and M is a water soluble cation. Non-limiting examples of these include sodium lauroyl glutamate and sodium cocoyl glutamate.

Other anionic materials include alkanoyl sarcosinates corresponding to the formula R ¹ CON (CH ₃ ) -CH ₂ CH ₂ -CO ₂ M, wherein R ¹ is a saturated or unsaturated, branched or unbranched, 10 to about 20 alkyl and alkenyl groups, and M is a water soluble cation. Non-limiting examples of these include sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, and ammonium lauroyl sarcosinate.

Other anionic materials include alkyl ether carboxylates corresponding to the formula R ¹ - (OCH ₂ CH ₂ ) _x -OCH ₂ -CO ₂ M wherein R ¹ is a saturated or unsaturated, branched or unbranched carbon number An alkyl or alkenyl group of about 8 to about 24, x is 1 to 10, and M is a water soluble cation. Non-limiting examples of these include sodium laureth carboxylate.

Other anionic materials include acyl lactylates corresponding to the formula R ¹ CO- [O-CH (CH ₃ ) -CO] _x -CO ₂ M, wherein R ¹ is a saturated or unsaturated, branched or unbranched An alkyl or alkenyl group having from about 8 to about 24 carbon atoms, x is 3, and M is a water soluble cation. Non-limiting examples of these include sodium cocoyl lactylate.

Other anionic materials include carboxylates, and non-limiting examples thereof include sodium lauroyl carboxylate, sodium cocoyl carboxylate, and ammonium lauroyl carboxylate. Anionic fluorinated surfactants may also be used.

Other anionic materials include natural soaps derived from saponification of vegetable and / or animal fats and oils, including, for example, sodium laurate, sodium myristate, palmitate, stearate, tallowate, cocoate .

Any mating cation M can be used in the anionic surfactant. Preferably, the counter cation is selected from the group consisting of sodium, potassium, ammonium, monoethanolamine, diethanolamine, and triethanolamine. More preferably, the counter cation is ammonium.

Nonionic foam forming surfactant

Non-limiting examples of nonionic foam-forming surfactants used in the compositions of the present invention are disclosed in McCutcheon's, Detergents and Emulsifiers , North American edition (1986), published by allured Publishing Corporation; And McCutcheon's Functional Materials , North American Edition (1992), all of which are incorporated herein by reference in their entirety.

Useful nonionic foam forming surfactants herein include those selected from the group consisting of alkyl glucosides, alkyl polyglucosides, polyhydroxy fatty acid amides, alkoxylated fatty acid esters, sucrose esters, amine oxides, and mixtures thereof .

Alkyl glucosides and alkylpolyglucosides are useful herein and they are broadly exemplified by long chain alcohols, such as C8-30 alcohols, with sugar or starch, or with sugar or starch polymers such as glycosides or polyglycosides Can be defined as condensation products. The compounds may be represented by the formula (S) _n -OR wherein S is a sugar moiety such as glucose, fructose, mannose, and galactose; n is an integer from about 1 to about 1000, and R is a C8-30 alkyl group. Examples of the long chain alcohol from which the alkyl group can be derived include decyl alcohol, cetyl alcohol, stearyl alcohol, lauryl alcohol, myristyl alcohol, oleyl alcohol and the like. Preferred examples of such surfactants include those wherein S is a glucose moiety, R is an alkyl group of C8-20, and n is an integer of about 1 to about 9. [ Examples of such commercially available surfactants include decyl polyglucoside (available as APG 325 CS from Henkel) and lauryl polyglucoside (commercially available as APG 600 CS and 625 CS from Henkel). Sucroxester surfactants such as sucrose cocoate and sucrose laurate are also useful.

Other useful nonionic surfactants include polyhydroxy fatty acid amide surfactants, and more specific examples include glucosamides corresponding to the following chemical formulas:

Wherein R ¹ is H, C ₁ -C ₄ alkyl, 2-hydroxyethyl, 2-hydroxy-propyl, preferably C ₁ -C ₄ alkyl, more preferably methyl or ethyl, Methyl; R ² is C ₅ to C ₃₁ alkyl or alkenyl, preferably C ₇ to C ₁₉ alkyl or alkenyl, more preferably C ₉ to C ₁₇ alkyl or alkenyl, most preferably C ₁₁ to C ₁₅ alkyl Or alkenyl; Z is a polyhydroxyhydrocarbyl moiety having a linear hydrocarbyl chain having at least three hydroxyls directly connected to the chain, or an alkoxylated (preferably ethoxylated or propoxylated) derivative thereof. Z is preferably a sugar moiety selected from the group consisting of glucose, fructose, maltose, lactose, galactose, mannose, xylose and mixtures thereof. Particularly preferred surfactants corresponding to this structure are coconut alkyl N-methyl glucoside amides (i.e. the R ² CO- moiety in the formula is derived from coconut oil fatty acid). Methods for making compositions containing polyhydroxy fatty acid amides are described, for example, in British Patent Specification No. 809,060 (published February 18, 1959, Thomas Hedley & Co., Ltd.); U.S. Patent No. 2,965,576 [ER Wilson, issued December 20, 1960]; U.S. Patent No. 2,703,798 [AM Schwartz, issued March 8, 1955]; And U.S. Patent No. 1,985,424 [Piggott, issued December 25, 1934]; Each of which is incorporated herein by reference in its entirety.

Other examples of nonionic surfactants include amine oxides. Amine oxides correspond to the formula R ₁ R ₂ R ₃ N → O, wherein R ₁ is selected from the group consisting of about 8 to about 18 carbon atoms, 0 to about 10 ethylene oxide moieties, and 0 to about 1 glyceryl moiety R ₂ and R ₃ are independently selected from the group consisting of carbon atoms of from about 1 to about 3, and hydroxy groups of from 0 to about 1, such as methyl, ethyl, propyl, hydroxyethyl, Or hydroxypropyl radicals. The arrows in the above formula are typical signs of semi polar bonding. Examples of suitable amine oxides for use in the present invention include dimethyl-dodecylamine oxide, oleyldi (2-hydroxyethyl) amine oxide, dimethyloctylamine oxide, dimethyl-decylamine oxide, Decylamine oxide, 3,6,9-trioxaheptadecyldiethylamine oxide, di (2-hydroxyethyl) -tetradecylamine oxide, 2-dodecoxyethyldimethylamine oxide, 3- 2-hydroxypropyl di (3-hydroxypropyl) amine oxide, and dimethylhexadecylamine oxide.

Non-limiting examples of nonionic surfactants that are preferred for use herein include C8-C14 glucose amides, C8-C14 alkyl polyglucosides, sucrose cocoate, sucrose laurate, laurylamine oxide, cocoamine oxide, And mixtures thereof.

Cationic foam-forming surfactant

Cationic foam-forming surfactants are also useful in the articles of the present invention. Suitable cationic foaming surfactants include, but are not limited to, fatty amines, di-fatty quaternary amines, tri-fatty quaternary amines, imidazolinium quaternary amines, and combinations thereof. Suitable fatty amines include monoalkyl quaternary amines such as cetyltrimethylammonium bromide. A suitable quaternary amine is dialkylamidoethylhydroxyethylmonium methosulfate. However, fatty amines are preferred. If the cationic foam-forming surfactant is the main foam-forming surfactant of the cleansing component, it is preferred to use a foam-forming promoter. It has also been found that nonionic surfactants are particularly useful when used with such cationic foam forming surfactants.

Amphoteric foam forming surfactant

As used herein, the term " amphoteric foam forming surfactant " is intended to encompass well known zwitterionic surfactants, well known to the skilled artisan, as subset of amphoteric surfactants Respectively.

A wide variety of amphoteric foam forming surfactants may be used in the compositions of the present invention. In particular, those broadly mentioned as derivatives of aliphatic secondary and tertiary amines are particularly useful, preferably wherein the nitrogen is cationic, the aliphatic radicals are linear or branched, and one of the radicals is ionized Soluble water-soluble groups, such as carboxy, sulfonate, sulfate, phosphate, or phosphonate.

Non-limiting examples of amphoteric surfactants useful in compositions of the present invention include McCutcheon's, Detergents and Emulsifiers , North American edition (1986) (allured Publishing Corporation); And McCutcheon's, Functional Materials , North American Edition (1992), all of which are incorporated herein by reference in their entirety.

Non-limiting examples of amphoteric or zwitterionic surfactants are selected from the group consisting of betaines, sultaines, hydroxysultaines, alkyliminoacetates, iminodialcanoates, aminoalkanoates, and mixtures thereof They are.

Examples of betaine are cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethylcarboxyethylbetaine, cetyldimethylcarboxymethylbetaine, cetyldimethylbetaine (available as Lonzaine 16SP from Lonza Corp.) ), Laurylbis- (2-hydroxyethyl) carboxymethylbetaine, oleyldimethylgamma-carboxypropylbetaine, laurylbis- (2-hydroxypropyl) alpha-carboxyethylbetaine, cocodimethylsulfopropyl (2-hydroxyethyl) sulfopropyl betaine, amidobetaine, and amidosulfobetaine, wherein the RCONH (CH ₂ ) ₃ radical is selected from the group consisting of nitrogen of betaine (Commercially available from Henkel as Velvetex OLB-50), and cocamidopropyl betaine (available from Henkel as Velvetex BK-35 and BA-35) Includes others.

Examples of sultaine and hydroxysultaine include materials such as cocamidopropylhydroxysultaine (available as Mirataine CBS from Rhone-Poulenc).

It is preferred that amphoteric surfactants having the following structure be used:

In the formula, R ¹ is an unsubstituted, saturated or unsaturated, straight or branched chain alkyl of about 9 to about 22 carbon atoms. R ¹ preferably has about 11 to about 18 carbon atoms, more preferably about 12 to about 18 carbon atoms; Even more preferably from about 14 to about 18 carbon atoms; m is an integer from 1 to about 3, more preferably from about 2 to about 3, and even more preferably about 3; n is 0 or 1, preferably 1; R ² and R ³ are independently selected from the group consisting of alkyl having 1 to about 3 carbon atoms and unsubstituted or monosubstituted with hydroxy groups, preferably R ² and R ³ are CH ₃ ; X is selected from the group consisting of CO ₂ , SO ₃ and SO ₄ ; R ⁴ is selected from the group consisting of alkyl having 1 to about 5 carbon atoms, saturated or unsaturated, linear or branched, unsubstituted or monosubstituted with hydroxy groups. When X is CO ₂ , R ⁴ is preferably 1 or 3 carbon atoms, more preferably 1. When X is SO ₃ or SO ₄ , R ⁴ preferably has about 2 to about 4 carbon atoms, and more preferably 3 carbon atoms.

Examples of amphoteric surfactants of the present invention include the following compounds:

Cetyldimethylbetaine (the name of CTFA is cetyl betaine)

Cocamidopropyl betaine

(Wherein the number of carbon atoms of R is about 9 to about 13)

Cocamidopropylhydroxysulfate

(Wherein the carbon number of R is about 9 to about 13).

Examples of other useful amphoteric surfactants are alkyliminoacetates and iminodialkanoates of the formula RN [(CH ₂ ) _m CO ₂ M] ₂ and RNH (CH ₂ ) _m CO ₂ M and aminoalkanoates and a, and where m is 1 to 4, R is alkyl or alkenyl of Al C ₈ ~ C _22, m is H, alkali metal, alkaline earth metal, ammonium or alkanol ammonium. Also included are imidazolidinium and ammonium derivatives. Specific examples of suitable amphoteric surfactants include sodium 3-dodecyl-aminopropionate, sodium 3-dodecylaminopropanesulfate, sodium 3-dodecylaminopropionate, and the like, as prepared in accordance with the teachings of U.S. Patent No. 2,438,091, incorporated herein by reference in its entirety. Nate, N-higher alkyl aspartic acid; And the products described in U.S. Patent No. 2,528,378, which is marketed under the trade name " Miranol &quot;, incorporated herein by reference in its entirety. Examples of other amphoteric materials that are useful include amphiphilic phosphates such as coramidopropyl PG-dimonium chloride phosphate (available as Monaquat PTC from Mona Corp.). Amphoacetates such as disodium lauroamphodiacetate, sodium lauroamphoacetate, and mixtures thereof are also useful.

Preferred foam-forming surfactants are ammonium lauroyl sarcosinate, sodium trideceth sulfate, sodium lauroyl sarcosinate, ammonium laureth sulfate, sodium laureth sulfate, ammonium lauryl sulfate, sodium lauryl sulfate, Ammonium cocoyl isethionate, sodium cocoyl isethionate, sodium lauroyl isethionate, sodium cetyl sulfate, sodium monolauryl phosphate, sodium coco glyceryl ether sulphonate, sodium C ₉ -C ₂₂ Anionic foaming surfactants selected from the group consisting of soaps, and combinations thereof; Nonionic foam selected from the group consisting of laurylamine oxide, cocoamine oxide, decyl polyglucose, lauryl polyglucose, sucrose cocoate, C12-14 glucosamides, sucrose laurate, and combinations thereof Forming surfactants; A cationic foam-forming surfactant selected from the group consisting of fatty amines, di-fatty quaternary amines, tri-fatty quaternary amines, imidazolinium quaternary amines, and combinations thereof; An amphoteric foam-forming surfactant selected from the group consisting of disodium lauroamphodiacetate, sodium lauroamphoacetate, cetyldimethylbetaine, cocoamidopropyl betaine, cocoamidopropylhydroxysultaine, and combinations thereof &Lt; / RTI &gt;

Cationic surfactant

Cationic surfactants are typically classified as non-foam forming surfactants, but can be used in the articles of the present invention, provided they do not adversely affect the preferred advantages of the article of the present invention.

Non-limiting examples of cationic surfactants useful herein include McCutcheon ' s Detergents and Emulsifiers , North American Edition (1986), published by allured Publishing Corporation; And McCutcheon's, Functional Materials , North American Edition (1992); All of which are incorporated herein by reference in their entirety.

Non-limiting examples of cationic surfactants useful herein include cationic alkylammonium salts such as those having the formula:

R ₁ R ₂ R ₃ R ₄ N ⁺ X ^-

Wherein R ₁ is selected from an alkyl group having from about 12 to about 18 carbon atoms or an aromatic, aryl or alkaryl group having from about 12 to about 18 carbon atoms; R ₂ , R ₃ and R ₄ are independently selected from hydrogen, an alkyl group having from about 1 to about 18 carbon atoms, or an aromatic, aryl or alkaryl group having from about 12 to about 18 carbon atoms; X is an anion selected from chloride, bromide, iodide, acetate, phosphate, nitrate, sulfate, methylsulfate, ethylsulfate, tosylate, lactate, citrate, glycolate, and mixtures thereof. Additionally, the alkyl group may also contain ether linkages, or hydroxy or amino group substituents (e.g., the alkyl group may contain polyethylene glycol and polypropylene glycol components).

More preferably, R &lt; ₁ &gt; is an alkyl group having from about 12 to about 18 carbon atoms; R ₂ is selected from hydrogen or an alkyl group having from about 1 to about 18 carbon atoms; R ₃ and R ₄ are independently selected from hydrogen or an alkyl group having from about 1 to about 3 carbon atoms; X is as described in the preceding paragraph.

Most preferably, R &lt; ₁ &gt; is an alkyl group having from about 12 to about 18 carbon atoms; R ₂ , R ₃ , and R ₄ are selected from hydrogen or an alkyl group having from about 1 to about 3 carbon atoms; X is as described above.

Alternatively, other useful cationic surfactants include amino-amides comprising a, in which in formula R ₁ is optionally _{R 5 CO- (CH 2) n} - [ wherein, R ₅ is a carbon number of from about 12 to about N is an integer from about 2 to about 6, more preferably from about 2 to about 4, and most preferably from about 2 to about 3. Non-limiting examples of the cationic emulsifier include stearamidopropyl PG-dimonium chloride phosphate, stearamidopropyl ethyl dimonium ethosulfate, stearamidopropyl dimethyl (myristyl acetate) ammonium chloride, stearamidopropyl dimethyl Cetearyl ammonium tosylate, stearamidopropyl dimethyl ammonium chloride stearamidopropyl dimethyl ammonium lactate, and mixtures thereof.

Non-limiting examples of quaternary ammonium salt cationic surfactants include cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium Examples of the organic solvent include bromine, lauryldimethylammonium chloride, lauryldimethylammonium bromide, stearyldimethylammonium chloride, stearyldimethylammonium bromide, cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, lauryltrimethylammonium chloride, lauryltrimethylammonium bromide, Trimethylammonium chloride, stearyltrimethylammonium bromide, lauryldimethylammonium chloride, stearyldimethylcetyldialdimethylammonium chloride Dicetylammonium chloride, dicetylammonium bromide, dicetylammonium bromide, distearylammonium bromide, distearylammonium chloride, distearylammonium bromide, dicetylmethylammonium chloride, dicetylmethylammonium bromide, dilaurylmethylammonium bromide, But are not limited to, those selected from the group consisting of chloride, dilaurylmethylammonium bromide, distearylmethylammonium chloride, distearyldimethylammonium chloride, distearylmethylammonium bromide, and mixtures thereof. Additional quaternary ammonium salts include those wherein the C ₁₂ to C ₂₂ alkyl carbon chain is derived from tallow fatty acids or coconut fatty acids. The term " tallow " refers generally to an alkyl group derived from a tallow fatty acid (generally hydrogenated tallow fatty acid) having a mixture of alkyl chains in the C ₁₆ to C ₁₈ range. The term " coconut " refers to an alkyl group derived from coconut fatty acid having a mixture of alkyl chains generally in the C ₁₂ to C ₁₄ range. Examples of quaternary ammonium salts derived from such trough and coconut sources include ditallow dimethyl ammonium chloride, ditallow dimethyl ammonium methyl sulfate, di (hydrogenated tallow) dimethyl ammonium chloride, di (hydrogenated tallow) dimethyl (Coconut alkyl) dimethyl ammonium bromide, tallowammonium chloride, coconut ammonium chloride, stearamidopropyl PG-1 (coconut alkyl) dimethyl ammonium chloride, dibutyl ammonium chloride, Stearamidopropyldimonium ethosulfate, stearamidopropyldimethyl (myristyl acetate) ammonium chloride, stearamidopropyl dimethyl cetearyl ammonium tosylate, stearamidopropyl dimethyl ammonium chloride Lauride, stearamidopropyl dimethyl ammonium lactate, and mixtures thereof.

Cationic surfactants useful herein are selected from the group consisting of dilauryl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, dimyristyl dimethyl ammonium chloride, dipalmityl dimethyl ammonium chloride, distearyl dimethyl ammonium chloride, &Lt; / RTI &gt;

Chelartors

The articles of the invention may also contain a safe effective amount of a chelator or chelating agent. As used herein, " chelator " or " chelating agent " means an active agent capable of removing metal ions from the system by forming complexes such that the metal ions do not readily react or catalyze chemical reactions. The inclusion of a chelating agent is particularly useful in providing protection against UV radiation that can contribute to excessive scaling or skin texture changes, and other environmental factors that can cause skin damage.

A safe effective amount of a chelating agent may be added to the compositions of the present invention, preferably from about 0.1% to about 10%, more preferably from about 1% to about 5% of the composition. An exemplary chelator useful herein is U.S. Patent No. 5,487,884 (issued January 30, 1996 to Bissett et al.); International Publication No. 91/16035 (Bush et al., Published October 31, 1995); And International Publication No. 91/16034 (Bush et al., Published October 31, 1995). Preferred chelators useful in the compositions of the present invention are fuoridoxime and derivatives thereof.

Flavonoid

The article of the present invention may optionally comprise a flavonoid compound. Flavonoids are described extensively in U.S. Patent Nos. 5,686,082 and 5,686,367, which are incorporated herein by reference. Flavonoids suitable for use in the present invention include flavanones selected from the group consisting of unsubstituted flavanones, mono-substituted flavanones, and mixtures thereof; A chalcone selected from the group consisting of unsubstituted chalcone, mono-substituted chalcone, di-substituted chalcone, tri-substituted chalcone, and mixtures thereof; A flavone selected from the group consisting of unsubstituted flavone, mono-substituted flavone, di-substituted flavone, and mixtures thereof; One or more isoflavones; Coumarin selected from the group consisting of unsubstituted coumarin, mono-substituted coumarin, di-substituted coumarin, and mixtures thereof; A chromone selected from the group consisting of unsubstituted chromone, mono-substituted chromone, di-substituted chromone, and mixtures thereof; At least one decumarole; At least one chromanone; At least one chromanol; Isomers thereof (e.g., cis / trans isomers); And mixtures thereof. The term " substituted " as used herein means a flavonoid in which one or more hydrogen atoms of the flavonoid are independently replaced by hydroxyl, C1-C8 alkyl, C1-C4 alkoxy, O-glycoside, or the like, or a mixture of such substituents.

Examples of suitable flavonoids include, but are not limited to, unsubstituted flavanone, mono-hydroxy flavanone (e.g., 2'-hydroxy flavanone, 6-hydroxy flavanone, 7-hydroxy flavanone, etc.) ), Mono-alkoxyflavanones (e.g., 5-methoxy flavanone, 6-methoxy flavanone, 7-methoxy flavanone, 4'-methoxy flavanone, Dihydroxychalcone (for example, 2 ', 4-dihydroxychalcone), mono-hydroxycalcone (for example, 2'- Dihydroxycalcone, 2'4'-dihydroxycalcone, 2,2'-dihydroxychalcone, 2 ', 3-dihydroxychalcone, 2', 5'- dihydroxychalcone, etc.), and trihydroxy (2 ', 3', 4'-trihydroxychalcone, 4,2 ', 4'-trihydroxychalcone, 2,2', 4'-trihydroxychalcone, etc.) Dihydroxyflavone, 3'4'-dihydroxynaphtho toflavone, 4'-hydroxypara 5,6-benzoflavone, 7,8-benzoflavone, unsubstituted isoflavone, deadzine (7,4'-dihydroxyisoflavone), 5,7-dihydroxy-4'- Hydroxy-4-methylcoumarin, unsubstituted chromone, 3-hydroxy-4-methylcoumarin, and mixtures thereof. Formylchromone, 3-formyl-6-isopropylchromone, unsubstituted dicumarol, unsubstituted chromanone, unsubstituted chromanol, and mixtures thereof.

It is preferred that the unsubstituted flavanone, methoxy flavanone, unsubstituted chalcone, 2 ', 4-dihydroxychalcone, and mixtures thereof are used herein. Unsubstituted flavanones, unsubstituted chalcones (especially trans isomers), and mixtures thereof are most preferred.

These may be synthetic or may be obtained as extracts from natural sources (e.g., plants). Substances from natural sources may be further derivatized (e. G., Glycosides, esters or ether derivatives prepared from natural sources). The useful flavonoid compounds herein are commercially available from a number of suppliers including, for example, Indofine Chemical Company, Inc. (Somerville, New Jersey), Steraloids, Inc. (Wilton, New Hampshire), and Aldrich Chemical Company, , Wisconsin).

Mixtures of the above flavonoid compounds may also be used.

The flavonoid compounds described herein are preferably present in the present invention at a concentration of from about 0.01% to about 20%, more preferably from about 0.1% to about 10%, and most preferably from about 0.5% to about 5%.

Sterol

The articles of the invention may contain one or more sterol compounds in a safe effective amount. Examples of useful sterol compounds include sitosterol, stigmasterol, campesterol, brassicasterol, lanosterol, 7-dehydrocholesterol, and mixtures thereof. These may be synthetic or natural sources, such as mixtures extracted from plant sources (eg, phytosterols).

Anticellulite

The articles of the invention may also contain a safe effective amount of an anti-cellulite agent. Suitable formulations may include, but are not limited to, xanthine compounds (e.g., caffeine, theophylline, theobromine, and aminophylline).

Skin whitening agent

The articles of the present invention may contain a skin lightening agent. When used, the compositions preferably contain from about 0.1% to about 10%, more preferably from about 0.2% to about 5%, and more preferably from about 0.5% to about 2%, of a skin lightening agent do. Suitable skin lightening agents include those known in the art, including kojic acid, arbutin, ascorbic acid and derivatives thereof, such as magnesium ascorbyl phosphate or other salts of sodium ascorbyl phosphate or ascorbyl phosphate . Suitable skin lightening agents for use herein are also described in co-pending patent application Serial No. 08 / 479,935 (filed June 7, 1995 under the name of Hillebrand), corresponding PCT Application No. 95/07432 (filed June 12, 1995) ; And co-pending patent application Ser. No. 08 / 390,152 filed February 24, 1995 under the names of Kalla L. Kvalnes, Mitchell A. DeLong, Barton J. Bradbury, Curtis B. Motley, and John D. Carter, PCT Application US 95/02809 (filed March 1, 1995, published September 8, 1995).

Binder

The article of the present invention may optionally comprise a binder. Binders or bonding materials are useful for maintaining the integrity of an article by sealing multiple layers of the article of the present invention together. The binder may be in various forms including, but not limited to, spray, web, separating layer, bonded fibers, and the like. Suitable binders may include latexes, polyamides, polyesters, polyolefins, and combinations thereof.

Additional layers

In other embodiments, the article of the present invention is recognized by those skilled in the art as distinct from the nonwoven layer, but may in some respect include one or more additional layers attached to the nonwoven layer. The additional layers are suitable for enhancing the overall grippability of the portion closest to the hand of the article or other means for exhibiting mechanical action on the surface to be cleansed. The additional layers are also suitable for enhancing the soft touch of the portion of the article that is in contact with the portion to be cleansed. In any case, these additional layers may be referred to as a continuous numbered layer, such as a third layer, a fourth layer, etc., in addition to the two layers essential to the article of the present invention.

Suitable additional layers can be macroscopically expanded. The expression " macroscopically expanded ", as used herein, is intended to encompass a web, a ribbon, a web, or the like, which is adapted to the surface of a three-dimensional shaping structure so that both surfaces thereof all exhibit a three- dimensional shaping pattern of the surface deformation corresponding to the macroscopic cross- And film wherein the surface deformations containing the pattern are at a normal distance of approximately 12 inches from the viewer's eye and the web surface, Can be distinguished as.

As used herein, the expression " embossed " means that the forming structure of a material represents a pattern that includes protrusions predominantly protruding. On the other hand, the expression " debossed " refers to the case where the molding structure of a material represents a pattern including a primarily depressed capillary network.

A preferred macroscopically expanded film comprises a shaped film which is a structural carbon film. Such films are described in U.S. Patent No. 5,554,145 [Roe et al., Issued September 10, 1996], which is hereby incorporated by reference in its entirety.

Materials suitable for use in additional layers having a thickness of greater than or equal to 1 millimeter include, but are not limited to, web materials disclosed in U.S. Patent No. 5,518,801 (Chappell et al., Issued May 21, 1996), which is incorporated herein by reference in its entirety .

Manufacturing method

Personal care articles of the present invention include, but are not limited to, sprinkling, dip coating, spraying, slot coating, and roll transfer (e.g., pressure rolls or kiss rolls) (If applicable) to an appropriate sheet of the first layer that is a nonwoven through conventional methods that can be applied to the first layer. The sheet of the remaining layer is then placed, preferably, but not necessarily, on the sheet of the first layer for the therapeutic efficacy member (if applicable). The sheets are sutured together by conventional suturing methods which may include, but are not limited to, heat, pressure, pull, ultrasound, and the like. The heated stitchers can be of various designs and, when not possible to seal, insert a low melting hot-melt synthetic fibrous web, such as a polyamide fibrous web known as Wonder Under (manufactured by Pellon, H.Levinson & Co., Chicago, IL) Layer can be used between the layers for these and other examples without changing the effectiveness or utility of the article. Thereafter, the sealed sheets are distributed in units for consumer use. Any manufacturing steps may include calendaring to flatten the article and drying, creping, shrinking, stretching or other mechanical deformation steps.

Cleansing and treatment of skin or hair or delivery of cosmetic ingredients

The present invention also relates to a method of cleansing the skin or hair with the personal care article of the present invention. These methods comprise the following steps: a) a water-insoluble substrate containing a nonwoven; And a substantially dry disposable personal care article comprising a therapeutically efficacious member disposed adjacent the water insoluble substrate wherein the component comprises a safe effective amount of anion of from about 10% to about 1000% Wherein the composition comprises a therapeutically effective composition comprising a polymer and a safe effective amount of a cationic surfactant, wherein the composition forms a coacervate when the article is exposed to water; And b) contacting the wetted article with skin or hair.

The article of the present invention is water-activated, and therefore must be wetted with water before use. The expression " water-activated ", such as used herein, means that the present invention is provided to the consumer in a dry form to be used after being wetted with water. When the article of the present invention comprises a foam-forming surfactant, it has been found that by contact with water and further agitation they contain bubbles or are " activated ". Thus, the article is wetted by immersion in water or by placing it under water flow. When the article of the present invention contains a foam-forming surfactant, foam may be generated from the article by mechanically stirring and / or deforming the article before or during contact with the skin or hair. The resulting foam is useful for cleansing the skin or hair. During the cleansing process and during continuous rinsing with water, any therapeutic or cosmetic agent is deposited on the skin or hair. The deposition of the therapeutic or cosmetic efficacious component is enhanced not only by the physical contact of the skin or hair with the substrate, but also by the incorporation of one or more deposition aids.

The following examples further illustrate and demonstrate implementations falling within the scope of the present invention. In the following examples, all constituents are listed as active levels. It is to be understood that the embodiments are for purposes of illustration only and that various changes may be made thereto without departing from the spirit and scope of the invention, Should not be construed as being.

The constituents are identified by chemical name or CTFA name.

Ⅰ. Cleansing ingredient

Example 1

Representative powder cleansing ingredients for the articles of the invention are prepared by the following method.

Cut 40.0 gms of bar soap containing the following ingredients:

ingredient weight% Soap (magnesium and sodium) 80.16 water 11.50 Stearic acid 5.70 NaCl 1.10 EDTA 0.25 Spices 1.15 Other (with pigment) 0.14 synthesis 100

The bar soap flakes are blended with sodium bicarbonate in a weight ratio of 90:10. The mixture is pulverized twice in a standard 3-roll mill. The flakes are collected and stored in a suitable sealed container.

Example 2

A representative cleansing component comprising the following ingredients is prepared.

ingredient weight% Decyl polyglucose 12.0 Cocamidopropyl betaine 12.0 Sodium lauroyl sarcosinate 12.0 Butylene glycol 3.6 PEG 14M 1.8 Polyquaternium-10 0.9 Dexpanthenol 0.7 Phenoxyethanol 0.5 Benzyl alcohol 0.5 Methyl paraben 0.45 Propylparaben 0.25 Disodium EDTA 0.2 water 55.1

Example 3

A representative cleansing component comprising the following ingredients is prepared.

ingredient weight% Monosodium lauroyl glutamate 22.0 Cocamidopropyl betaine 2.0 Sodium chloride 1.0 glycerin 2.5 water 72.5

The components are heated together with gentle stirring until homogeneous.

Ⅱ. Beneficial therapeutic ingredients

Example 4

Representative skin conditioning ingredients are prepared by mixing the following ingredients.

ingredient Example 4 SEFA ^* Cotonate 48.0 SEFA ^* Behenate 12.0 Petrolatum 10.0 Cholesterol ester 25.0

^* SEFA is an acronym for sucrose esters of fatty acids.

¹ Hamplex TNP, Hampshire Chemical Co.

Example 5

Representative conditioning components for the articles of the present invention are prepared in the following manner.

ingredient Example 5 Small Prize: SEFA ^* Cotonate 15.5 SEFA ^* Behenate 8.0 Tribe henin 6.0 Petrolatum 4.0 C ₁₀ -C ₃₀ cholesterol / lanosterol ester 13.0 PEG 30 dipolyhydroxy stearate ³ 3.0 Awards: glycerin 42.30 PVM / MA decadiene crosslinked polymer ⁴ 0.25 Sodium hydroxide (10% solution) 0.25 Active skin care Ingredients: Panthenol 2.50 Nicotinamide 2.50 Urea 2.50 Allantoin 0.20

^* SEFA is an acronym for sucrose esters of fatty acids.

¹ Available as AMS-C30 from Dow Corning.

² Available as Abil WE-09 from Goldschmidt.

³ Available as Arlacel P135 from ICI.

Available as ⁴ Stabileze 06 from ISP.

Process for all emulsions:

The bovine aqueous phase is heated to 70 ° C, the hydrophobic active skin care ingredients are added and stirred until homogeneous. The hydrophilic active skin care ingredients and the biodegradable ingredients are premixed and, if necessary, heated slowly to dissolve or disperse them. These are slowly added to the bovine water and stirring is continued. Homogenize (high shear mixer, ultrasonic homogenizer, or high pressure homogenizer, for example Microfluidizer from Microfluidics Corp.). Immediately apply to the surface of the substrate or cool rapidly from ice or ice water to room temperature. If necessary, store in a controlled environment under nitrogen for chemical stability.

Examples 6-11

Representative conditioning components for the articles of the invention are prepared in the following manner.

Part A Example 6 Example 7 Example 8 Example 9 Example 10 Example 11 Sodium lauroyl ether sulfate (added as a SLES 27% active) 15.0 6.51 6.20 5.9 Cocamidopropyl betaine ¹ 13.5 5.85 5.57 5.82 5.19 5.3 Sodium lauroyl sarcosinate ² 1.35 0.60 0.57 6.01 5.36 0.54 Decyl polyglucose ³ 5.80 5.18 Lauryl alcohol 1.31 0.56 0.54 0.54 Polyethylene imine ⁴ 7.87 3.38 3.22 2.64 2.36 3.2 Citric acid (added in 50% aqueous solution) 0.32 0.11 0.11 0.09 Tetrasodium EDTA 0.28 Sulfuric acid 5.4 2.37 2.25 2.2 Preservatives, fragrances 0.62 0.45 0.43 2.86 2.55 0.3 Sodium sulfate 7.9 3.47 3.21 3.0 glycerin 26.45 56.7 46.4 44.1 39.36 44.8 Sorbitol 5.0 SEFA * Cotonate 12.8 SEFA * Behenate 8.0 Part B - Polymer Gelling Agent gelatin 4.2 Polyacrylamide and isoparaffin ⁵ 7.5 Polyurethane latex in 50% isopropanol ⁶ 34.1 Polyacrylate Copolymer ⁷ 7.5 Polystyrene sulfonate copolymer ⁸ 1.1 Chitosan lactate 5.4 Part C - Physical Gelling Agent 12-hydroxystearic acid 10.0 10.66 Stearyl alcohol 10.0 20.0 20.0 7.11 15.0

* SEFA is the acronym for sucrose esters of fatty acids.

¹ Commercially available from Goldschmidt as Tegobetaine F

² commercially available as Hamposyl L-30 (type 721) (31% active) from Hampshire Chemical

³ Available as Plantaren 2000NP from Henkel

⁴ Nippon Shokubai Co. Commercially available as Epomin SP-018 (molecular weight about 1800)

⁵ Available as Carbopol Ultrez from BF Goodrich

⁶ Commercially available as Sancure 2710 from premixed with approximately 20% polymer, 30% water, 50% IPA from BF Goodrich

⁷ Seppic Corp. Commercially available as Sepigel 305

⁸ Available as AQ38S from Eastman Chemical Company

The surfactant and fatty alcohol are mixed using a low speed impeller mixer while heating to 65 占 폚. Heat is removed and allowed to cool to 65 ° C while continuing to mix. The cationic polymer is added and stirred until homogeneous. The remaining Part A component is slowly added with stirring. Homogenize to disperse the SEFA as an emulsion. Titrate with concentrated sulfuric acid until the pH reaches about 6.5. The Part A composition is spread on a tray and dried in an appropriate (vacuum or convection) oven until no water remains at a temperature not exceeding 65 캜 to produce a dry mixture. The dried Part A component is combined with the polymeric gelling agent of Part B and heated to dissolve or disperse. The resulting composition is combined with a physical gelling agent. And the gelling agent is melted and dispersed in the composition by heating. Apply to the substrate surface (s), or cool and store at room temperature.

Examples 12-17

Representative conditioning components for the articles of the invention are prepared as described in Examples 6-11 using the following components.

Part A Example 12 Example 13 Example 14 Example 15 Example 16 Example 17 Sodium lauroyl sarcosinate ¹ 8.87 11.4 10.8 10.8 Polyethylene imine ² 7.39 7.50 7.50 9.5 9.0 9.0 water 4.43 3.00 3.00 5.7 5.4 5.4 Sulfuric acid 6.36 QS QS 8.1 7.7 7.7 Fragrance, other glycerin 34.45 52.5 45.0 41.3 39.25 34.25 Propylene glycol 2.50 Urea 2.50 2.50 2.0 1.9 1.9 Panthenol 2.0 1.9 1.9 Nicotinamide 2.50 2.50 2.0 1.9 1.9 Salicylic acid Polymethylsilsesquioxane ³ 4.20 4.20 Mica, pearl polish 3.85 3.85 Stearyl methicone wax 5.0 SEFA Cotonate 5.0 Petrolatum 5.0 Part B - Polymer Gelling Agent gelatin 0.1 Polyacrylamide and isoparaffin ⁴ 16.0 12.0 12.0 Part C - Physical Gelling Agent 12-hydroxystearic acid 12.0 12.0 10.5 Carnauba wax 18.0 14.1 14.1 Stearyl alcohol 8.0 8.0 7.0

¹ Available as Hamposyl L-95 (dried) from Hampshire Chemical

² Nippon Shokubai Co. Commercially available as Epomin SP-018 (molecular weight about 1800)

³ Kobo. Inc. Commercially available as Tospearl 145A

⁴ Seppic Corp. Commercially available from Sepigel 305

III. Intermediate personal care article

Example 18

A representative skin cleansing article is prepared in the following manner.

4 g of the cleansing component of Example 2 is applied to one side of a permeable, fusible web comprised of low melt heat sealable polyamide fibers. The transmissive web is a Wonder Under, manufactured by Pellon, and available from H. Levinson & Co., Chicago, IL. The cleansing composition is applied to an oval area of about 13 cm x 18 cm. The cleansing ingredients are air dried. Place a 2 oz / sq yd polyester batting layer, cut to the same size as the web, on the fusible web. The polyester bets have a basis weight of 2 oz / yd ² , at least a portion of which is fixed and contains a blend of fibers having an average diameter of about 23 microns and 40 microns. The thickness of the betting is about 0.23 inches measured at 5 gsi. It is believed that the betting is thermally bonded without using an adhesive. The nonwoven layer is positioned below the fusible web to form the second side of the article. The nonwoven is a spunlace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive which is hydroapertured to form pores with a diameter of about 2 mm, 70 gsm. The shape of the article is oval of about 122 mm x 160 mm. The layers are sealed together using point bonding on a grid pattern with a heat sealing die using a pressure platen hot sealing device such as a Sentinel Model 808 hot sealer from Sencorp [Hyannis, MA]. Point bonds are each measured at a diameter of about 4 mm and about 51 individual sealing points are uniformly located. Trim this item and use it immediately.

Example 19

A representative skin cleansing article is prepared in the following manner.

The cleansing composition of Example 2 was measured for width across the web and the coating head was placed on four lines separated at a distance of 20 mm, And is applied on one side of the first substrate. The cleansing component is extruded at a rate such that 4.4 grams of cleansing component per finished article is obtained. The substrate is a spun lace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, forming an aqueous pore to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. A second web, which is air-laid-out low-density betting, is continuously injected over the first substrate and placed in contact with the surfactant-containing layer. The betting contains 35% 3 denier bicomponent fibers with 15% denier PET fibers, PET core and PE sheath, and 35% blends of 10 denier bicomponent fibers of the same core-sheath composition, And a basis weight of about 100 grams per square meter (gsm). The web is continuously injected into an ultrasonic suture that sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. The web is cut into individual articles about 120 mm x 160 mm square in size with rounded corners, with a total of about 51 seals per article.

IV. The personal care article of the present invention.

Example 20

Representative skin cleansing and conditioning products are prepared in the following manner.

Three grams of the skin conditioning composition of Example 12 are applied on each side of the finished article of Example 18 on each side in half. The composition is applied by half-slot coating the composition on each side of the article, uniformly on the surface of the article, with the composition being a hot liquid (60-70 DEG C).

Example 21

Representative skin cleansing and conditioning products are prepared in the following manner.

Three grams of the skin conditioning composition of Example 5 is applied on each side of the finished article of Example 19 on each side in half. The composition is applied by half-slot coating the composition on each side of the article, uniformly on the surface of the article, with the composition being a hot liquid (60-70 DEG C).

Example 22

Representative skin cleansing and conditioning products are prepared in the following manner.

Three grams of the skin conditioning composition of Example 4 are applied on each side of the finished article of Example 19 on each side in half. The composition is applied by half-slot coating the composition on each side of the article, uniformly on the surface of the article, with the composition being a hot liquid (60-70 DEG C).

Example 23

Representative skin cleansing and conditioning products are prepared in the following manner.

Three grams of the skin conditioning composition of Example 12 is applied on each side of the finished article of Example 19 on each side in half. The composition is applied by half-slot coating the composition on each side of the article, uniformly on the surface of the article, with the composition being a hot liquid (60-70 DEG C).

Examples 24-31

Using the skin conditioning compositions of Examples 6-10 and 15-17, representative skin cleansing and conditioning products are prepared in the following manner.

4 grams of the cleansing component of Example 2 is spread evenly by hand over the lobed batting. The batting contains a blend of 35% 3 denier bicomponent fibers with 30% 15 denier PET fibers, PET core and PE sheath, and 35% with 10 denier bicomponent fibers of the same core-sheath composition, Laid, low density, with a basis weight of 100 g (gsm). A fibrous nonwoven layer having a basis weight of about 65 gsm and a wet tangled blend of 55% cellulose and 45% polyester (commercially available as Technicloth II from Texwipe Company (Saddle River, NJ) Over the surface. The layers are sutured together using an interlocking suture plate using a non-heated plate with an inverted thimble-shaped reservoir uniformly distributed in a hexagonal lattice pattern. The thimble reservoir is about 1.2 cm in diameter at the base and about 2 cm from the center-center lobe. The land portions between the dimples on the non-heated plate are concave to a few millimeters to form troughs connected to each other. The heating plate has an external ridge that exactly fits over the land portion of the non-heated plate. The heating plate is contacted with a cellulose / polyester substrate and heat-sealed using a pressure-platen heat sealer such as a Sentinel Model 808 heat sealer available from Sencorp (Hyannis, MA). The resulting unfinished article has a distinctive thimble shape with the batting surface raised and a shorter dimple or " button " on the cellulose / polyester substrate side of the article, both sides being easy to grip. The article is cut into a square of approximately 120 mm x 160 mm. Three grams of the skin conditioning composition per article is pipetted to the skin region during the hot period of the composition, allowed to cool and solidify. Pack the item until it is ready for use.

Examples 32-33

Using the skin conditioning compositions of Examples 13 and 14, representative skin cleansing and conditioning products are prepared in the following manner.

The liquid cleansing component of Example 3 is applied to the first substrate by immersing the 120 mm x 160 mm section of the substrate in the composition bath until the weight increases by about 8 grams. The substrate comprises a blend of 35% 3 denier bicomponent fibers having 30% 15 denier PET fibers, a PET core and a PE sheath, and 35% of the same core-sheath composition 10 denier bicomponent fibers, 100 g (gsm). The substrate is dried. A piece of a second substrate having an aqueous pore formed to form a hole of about 2 mm diameter and having a basis weight of about 70 gsm, with a spunlace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, Place on the substrate. The substrates are sutured together using an ultrasonic suturing machine which sutures with a dot pattern containing a grid of 4 mm diameter sealing points uniformly distributed throughout the article. Four grams of the skin conditioning composition is applied uniformly over both sides of the article by injecting the composition through a slotted rolling apparatus having an injection reservoir maintained at about 60 DEG C and a mechanized 1.5 mm gap. The composition is rapidly cooled on the surface of the article and stored in a sealed metallized film package until immediately used.

Example 34

Representative skin cleansing and conditioning products are prepared in the following manner.

Four grams of the cleansing composition of Example 2 is spread evenly over the batting lotion by hand. Betting is carried out using a Stevens Textiles (Cincinnati, OH) system with polyester bets of 4 oz / sq yd, containing polyester fibers of about 30 microns average diameter and cut to a size of 130 mm x 175 mm and bonded with an adhesive, In Mountain Mist Extra Heavy Batting # 205. A fibrous nonwoven layer having a basis weight of about 65 gsm and a wet tangled blend of 55% cellulose and 45% polyester (commercially available as Technicloth II from The Texwipe Company of Saddle River, NJ) Plane. The layers are sutured together using an interlocking suture plate using a non-heated plate with an inverted thimble reservoir uniformly distributed in a hexagonal lattice pattern. The thimble reservoir is about 1.2 cm in diameter at the base and 1.5 cm from the center-center lobe. The land portions between the dimples on the non-heated plate are convex up to several millimeters to form mutually connected ridges. The heating plate has an outer curve that exactly fits the ridge of the non-heated plate. The heating plate is contacted with a cellulose / polyester substrate and heat-sealed using a pressure-platen heat sealer such as a Sentinel Model 808 heat sealer available from Sencorp (Hyannis, MA). The resulting incomplete article has a three-dimensional feature on both sides that facilitates foam formation and facilitates slipping along the skin surface by gripping during use. The article is cut into a square of approximately 120 mm x 160 mm.

A skin conditioning inverse emulsion paste for use with the article is prepared as follows:

ingredient percent PEG 30-dipolyhydroxy stearate 3.0 SEFA Cotonate 20.0 Petrolatum 4.0 Tribe henin 5.0 C10-C30 cholesterol / lanosterol ester 13.0 SEFA Behenate 5.0 glycerin 50.0

The fat soluble component is heated to 70 캜 with stirring. Glycerin is slowly added with vigorous stirring. The composition is homogenized. Skin Conditioning 3 grams of inverse emulsion paste is pipetted into the pressed area on the cellulose / polyester side of the article in a hot state. The composition is quickly cooled with a semi-solid paste. Pack the item until it is ready for use.

Example 35

Using the skin conditioning composition of Example 7, a representative skin conditioning article is prepared in the following manner.

The conditioning composition was coated with four pieces each separated by a distance of 20 mm, 40 mm and 20 mm, measuring 5 mm width and width across the web, respectively, so that a pair of parallel lines were formed on each side of the web And is continuously extruded through a head to be coated on one side of the first substrate. The composition is extruded at a rate such that 3 grams of composition per finished article is obtained. The substrate is a spun lace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, forming an aqueous pore to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. A second web of lofted low density bet with an air addition is continuously injected over the first substrate and placed in contact with the first substrate on the side not containing the skin conditioning composition. The batting contains a blend of 35% 3 denier bicomponent fibers with 30% 15 denier PET fibers, PET core and PE sheath, and 35% with 10 denier bicomponent fibers of the same core-sheath composition, 100 g (gsm). The web is continuously injected into an ultrasonic suture that sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. The web is cut into individual articles about 120 mm x 160 mm square in size with rounded corners, with a total of about 51 stitching points per article.

Example 36

Using the skin conditioning composition of Example 16, a representative skin conditioning article is prepared in the following manner.

The conditioning composition was coated with four pieces each separated by a distance of 20 mm, 40 mm and 20 mm, measuring 5 mm width and width across the web, respectively, so that a pair of parallel lines were formed on each side of the web And is continuously extruded through a head to be coated on one side of the first substrate. The composition is extruded at a rate such that 1.1 grams of composition per finished article is obtained. The substrate is a spun lace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, forming an aqueous pore to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. A second web of lofted low density betting air is continuously injected over the first substrate and placed in contact with the first substrate on the side not containing the skin conditioning composition. The batting contains a blend of 10% 15 denier PET fibers, 50% 3 denier bicomponent fibers having a PET core and a PE sheath, and 40% of the same core-sheath composition 10 denier bicomponent fibers, 80 g (gsm). The web is continuously injected into an ultrasonic suture that sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. The web is cut into individual articles about 120 mm x 90 mm square in size with rounded corners, with a total of about 51 stitching points per article. The article is convenient to apply to narrower areas of the skin, such as the face, elbow, neck and / or feet.

Example 37

Using the skin conditioning composition of Example 16, representative skin cleansing and conditioning products are prepared in the following manner.

The cleansing composition of Example 2 was measured for width across the web and the coating head was placed on four lines separated at a distance of 20 mm, And is applied on one side of the first substrate. The cleansing component is extruded at a rate such that 0.52 grams of cleansing component per finished article is obtained. The substrate is a spun lace blend of 70% rayon and 30% PET fibers bonded with a styrene-butadiene adhesive, forming an aqueous pore to form pores with a diameter of about 2 mm and a basis weight of about 70 gsm. A second substrate web, which is air-laid lofted low density bet, is continuously injected over the first substrate and placed in contact with the surfactant layer. The batting contains a blend of 10% 15 denier PET fibers, 50% 3 denier bicomponent fibers having a PET core and a PE sheath, and 40% of the same core-sheath composition 10 denier bicomponent fibers, 80 g (gsm). A third substrate web identical to the second substrate web is continuously injected over the second substrate web and placed in contact with the second substrate. The web is continuously injected into an ultrasonic suture that sutures with a dot pattern containing a grid of uniformly distributed 4 mm diameter suture points across the web. Slot coating the skin conditioning composition from both sides of the substrate (approximately 55 gsm per side) at a rate equal to 1.25 grams of the skin conditioning composition per finished article, from the hot reservoir pumped through the slot dye, The cooling fan is passed through to cool rapidly on the surface. The web is cut into individual pieces of about 120 mm x 90 mm square in rounded corners.

Example 38

A representative skin cleansing and conditioning article is prepared in the following manner.

The substrate is manufactured by an air laying method. A thin first web of 20 gsm continuous polypropylene filament fibers is continuously fed to the forming screen. Cellulose (Kraft fibers) containing a second web is air laid on the first web at a rate of 100 gsm. The surfactant composition of Example 1 was co-measured with the cellulose fibers at a rate of about 80 gsm. A third web identical to the first web is fed onto the aerated cellulose. The substrate is prepared by about 51, 3 mm dot sealing of the 10 inch by 8.5 inch rectangular area of the composite web and thermal bonding of the edges. The skin conditioning composition of Example 15 is uniformly slot coated and melted on both sides of the article at a rate of 3 grams of composition per article or 1.5 grams of composition per side, and then rapidly cooled. Goods are packaged until use.

Example 39

A representative skin cleansing and conditioning article is prepared in the following manner.

The biodegradable polylactic acid polymer replaces polypropylene to make a biodegradable article, which is prepared as the article of Example 38. [

Claims (10)

A substantially dry disposable personal care article characterized by comprising: a) a water-insoluble substrate; And b) a therapeutic efficacy component disposed adjacent said water-insoluble substrate, Characterized in that it comprises from about 10% to about 1000% by weight of the water-insoluble substrate of a therapeutically efficacious composition containing the following items 1) and 2) and forming a coacervate when the article is exposed to water Article: 1) a safe effective amount of a cationic polymer; 2) Safe effective amount of anionic surfactant. The article of claim 1, wherein the nonwoven layer comprises fibers selected from the group consisting of natural fibers, synthetic fibers, and combinations thereof. 3. The article according to claim 1 or 2, wherein the fibers are synthetic fibers selected from the group consisting of nylon fibers, rayon fibers, polyolefin fibers, polyester fibers, and combinations thereof. 4. The nonwoven fabric of any one of claims 1 to 3, wherein the nonwoven layer is comprised of a cellulosic nonwoven, a sponge (i.e., a natural and synthetic sponge), a formed film, a batting, Lt; RTI ID = 0.0 &gt; 1, &lt; / RTI &gt; The method of any one of claims 1 to 4, wherein the cationic polymer is selected from the group consisting of natural backbone quaternary ammonium polymers, synthetic backbone quaternary ammonium polymers, natural backbone ampholytic polymers, synthetic backbone ampholytic polymers, &Lt; / RTI &gt; 6. The composition of any one of claims 1 to 5 wherein the anionic surfactant is selected from the group consisting of sarcosinates, glutamates, sodium alkyl sulfates, ammonium alkyl sulfates, sodium alkyl ethersulfates, ammonium alkyl ethersulfates, Wherein the material is selected from the group consisting of lactose, lactose, lactose, lactose, lactose, lactose, lactose, lactose, lactate-n-sulphate, sodium laureate-n-sulphate, isethionate, glyceryl ether sulphonate, sulfosuccinate and combinations thereof. 7. The method according to any one of claims 1 to 6, wherein the therapeutic efficacy member is further selected from the group consisting of a vitamin compound, a skin treatment agent, an anti-acne active, an anti-wrinkle activator, an anti-skin atrophy activator, An anti-oxidant, an anti-oxidant, a skin exfoliating agent, a hydrophobic conditioning agent, a hydrophilic conditioning agent, and combinations thereof, in combination with an anti-oxidant, an anesthetic, an artificial tanning activator and a promoter, an antibacterial activator, &Lt; RTI ID = 0.0 &gt; a &lt; / RTI &gt; therapeutic agent. A method of conditioning skin and / or hair comprising the following steps a) and b): a) wetting the article of claim 1; And b) contacting the skin and / or hair with the wetted article. 9. An article according to any one of claims 1 to 8, wherein the article further comprises a foam-forming surfactant. A method of cleansing the skin and / or hair, comprising the following steps a) and b): a) wetting the article of claim 9; And b) contacting the skin and / or hair with the wetted article.