KR20010111819A - The oral cleaning medicine containing the propolis - Google Patents
The oral cleaning medicine containing the propolis Download PDFInfo
- Publication number
- KR20010111819A KR20010111819A KR1020000032502A KR20000032502A KR20010111819A KR 20010111819 A KR20010111819 A KR 20010111819A KR 1020000032502 A KR1020000032502 A KR 1020000032502A KR 20000032502 A KR20000032502 A KR 20000032502A KR 20010111819 A KR20010111819 A KR 20010111819A
- Authority
- KR
- South Korea
- Prior art keywords
- propolis
- oral
- mouth
- bacteria
- oral cleaning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
본 발명은 입안의 악취를 제거하는 가글 기능과 잇틈에 기식하는 구강 세균을 멸균하며 잇몸 질환을 비롯한 구강계 질환에 대한 예방 치료효과가 우수한 구강 청결제(일명:가글제)를 제공하기 위한 것으로, 깨끗한 물 또는 오염되지 지하수 등의 물(H2O) 95 ~ 70%와, 프로폴리스 5∼30%가 배합되는 프로폴리스가 배합된 구강 청결제이다.The present invention is to provide an oral cleaning agent (aka: gargle) excellent sterilization of the mouth and mouth bacteria to remove odors in the mouth and sterilization of oral bacteria in the gums and excellent preventive treatment against oral diseases including gum disease. It is an oral cleanser containing 95 to 70% of water (H 2 O) such as groundwater or 5 to 30% of propolis blended with or not contaminated.
Description
본 발명은 잇틈에 기식하는 세균을 비롯한 구강 세균의 근절과 구강계 질환의 치료효과를 겸비하며, 특히, 입안의 악취를 제거할 때 행굼하는 일명 가글제를 제공하기 위해 안출된 프로폴리스가 배합된 구강 청결제(일명;가글제)에 관한 것이다.The present invention combines the effects of eradication of oral bacteria including oral bacteria, and oral diseases, and in particular, oral incorporating propolis formulated to provide a so-called gargle agent to remove odors in the mouth. It is about cleaning agent (aka; gargle).
이제까지 알려진 구강 청결제는 단순히 입냄새를 중화시켜 구취를 소취하고 맡기 좋은 향내를 풍기게 할 뿐, 잇틈을 비롯한 잇몸과 구강내에 기식하는 세균에 대한 살균작용은 애당초 기대할 수 없고 특히, 잇몸에 난 상처와 같은 구강계 질환의 치유와 예방의 효과를 기대하기란 더더욱 어려웠던 것이 사실이다.Oral cleansers so far known simply neutralize bad breath, deodorizing bad breath, giving off a good smell, and sterilizing effects on gums and gums and bacteria in the mouth cannot be expected in the first place. It was even more difficult to expect the effects of healing and preventing the same oral disease.
본 발명은 구강 세균의 살균과 구강계 질환의 예방과 치료에 유효하고 특히 새균으로 발생되는 입안의 악취를 효과적으로 제거할 수 있는 구강 청결제를 제공하려는 것이다.The present invention aims to provide an oral cleaning agent which is effective for the prevention and treatment of oral bacteria and the prevention and treatment of oral diseases, and in particular, can effectively remove the odor in the mouth caused by bacteria.
본 발명은 오염되지 않은 물(H2O) 95 ~ 70%에 프로폴리스 5∼30%를 혼합하여입안의 살균 및 구강계 질환의 예방과 치료효과에 탁월한 프로폴리스가 배합된 구강 청결제를 특징으로 한다.The present invention is characterized by oral cleansers containing propolis excellent in the prevention and treatment of mouth sterilization and oral disease by mixing 5-30% propolis with 95-70% uncontaminated water (H 2 O). do.
프로폴리스(propolis)란 벌집에서 채취한 수지상의 물질로서, 이 물질은 이미 의학계에서 널리 알려진 바와 같이, 새균의 침투예방 및 박멸기능과 특별한 향을 가지고 있으며 점착성을 지닌 물질로서, 색상은 황록색으로부터 암갈색까지 다양하고, 성상은 채취장소와 채취시간에 따라 다르다.Propolis is a dendritic substance obtained from honeycomb, which is already known in the medical profession. It has a special fragrance and prevents the penetration and eradication of bacteria, and its color is yellowish green to dark brown. Varies depending on the location and time of collection.
이러한 프로폴리스는 각종 수목으로부터 꿀벌이 채집한 것에 자신의 분비물을 혼합하여 만들어내는 것으로, 벌이 드나드는 벌집 입구와 그 내부에 발라두면 자연적으로 밀랍상태의 고채로 형성 된다.These propolis are produced by mixing their secretions with bees collected from various trees. When applied to the beehive entrance and inside of the bees, they form naturally waxy solids.
고체로 형성되는 조건은 온도에 따라 변하지만 상온에서는 굳은 상태로 존재하여 벌꿀의 채취 작업을 방해하고 자신들의 적으로부터의 침입을 방어하는 작용을 한다.The conditions that form as a solid vary with temperature, but remain solid at room temperature, hindering the harvesting of honey and protecting them from intrusion from their enemies.
이러한 프로폴리스가 무엇보다도 중요한 것은 바로 소독성 및 살균성이다. 프로폴리스의 독성은 매우 강력하다. 벌 이외의 곤충이 벌집을 침입하면 우선은 침을 쏴서 죽이고 그 사체는 프로폴리스로 무균상태로 유지하여 부패를 방지하여 미이라로 보존시킨다. 프로폴리스의 독성이 어느 정도인지를 가늠할 수 있는 대목이 아닐 수 없다.The most important of these propolis is disinfectant and bactericidal. The toxicity of propolis is very strong. When insects other than bees invade the beehive, they first shoot and kill them, and the carcasses remain aseptic as propolis to prevent decay and preserve them as mummies. It is a part that can measure the degree of toxicity of propolis.
꿀벌이 벌집으로 들어갈 때마다 그 출입구에 프로폴리스를 발라 둔다. 이 프로폴리스는 벌을 자연 소독시켜 항상 깨끗한 상태로 유지하고 고순도의 안전한꿀로 저장하는데 절대적 기여물질이다. 곤충과 동물의 몸에는 미생물이 기생하고 있는데, 유독 벌꿀에게서만은 그러한 기식 미생물이 발견되지 않는다. 바로 프로폴리스의 영향력 때문이다. 이처럼 프로폴리스의 자연 소독 및 살균작용은 실로 대단한 것이다.Every time a bee enters a beehive, propolis is applied to its doorway. This propolis is an absolute contributor to the natural disinfection of bees, keeping them clean at all times and storing them as safe, high-purity honey. Microbes are parasitic in the bodies of insects and animals, and only those poisonous honeys are not found. It is because of the influence of propolis. This natural disinfection and sterilization of propolis is indeed great.
프로폴리스에는 전분 가수분해효소로 전분을 당화하는 수액인 아밀라제, 페빈과 비슷한 효소로서 단백질을 분해하고 소화흡수를 촉진하여 위산과다에 유효하고 오래 된 세포를 없애고 새로운 세포로 교체하는 카텝신, 지방분해효소로서 프로테인을 함유하고 단백지의 소화를 돕는데다 강력한 조정력을 발휘하는 리파아제, 단백질의 소화흡수 촉진하고 체내의 죽은 세포를 제거하고 상처의 치유를 도아주며 암, 신장결석의 치유에도 기여하는 트립신, 기타 수종의 플라보노이드 미 플라본 등 인체에 유효한 각종 효소가 함유되어 있다. 이들 효소와 그 효능은 이제까지의 연구 결과에 의한 것으로서 아직도 밝혀지지 않은 물질이 많아 앞으로 진행되는 추가 연구 결과가 기대된다.Propolis is an enzyme similar to amylase and pevin, a sap that saccharizes starch with starch hydrolase, and cathepsin and lipolysis, which break down proteins and promote digestion and absorption, remove old cells and replace them with new ones. Lipase, which contains protein as an enzyme and helps protein digestion, exerts powerful control, trypsin promotes digestion and absorption of protein, removes dead cells in the body, helps wound healing, and also helps to cure cancer and kidney stones. It contains a variety of enzymes that are effective for the human body, such as other species of flavonoid mi flavones. These enzymes and their effects are based on the results of the previous studies, and there are many substances that are still unknown.
프로폴리스의 성분은 수지팔삼 55%, 왁스 30%, 유성물질 10%, 화분 5%이다. 이들은 더욱 세분하면 아래와 같다.The ingredients of propolis are 55% resin ginseng, 30% wax, 10% oily substance and 5% pollen. These are further broken down as follows.
알콜류: 신나밀(계피알콜), 디메독실 베질 알콜Alcohols: Cinnamic (Cinnamon Alcohol), Dimedoxyl Benzyl Alcohol
유기산류: 신나밀산(계피산), 카페인산, 페에루산, 미리스틴산, 소르빈산Organic acids: cinnamic acid (cinnamic acid), caffeic acid, peruic acid, myristic acid, sorbic acid
알데히드류: 바니린, 이소바니린,플라본산, 글리신, 덱토글리신, 아카세틴, 게세틴, 겐페리토, 라무노사트린, 겐파란긴, 이사르비닌, 토리나리게닌, 게르세틴 디 메틸, 에테르Aldehydes: vanillin, isovanirin, flavonic acid , glycine, detoglycine, acecetin, gecetin, genperito, lamunosartrin, genparangin, isarbinin, torinarigenin, quercetin dimethyl, ether
플라바논류: 피노스트로빈, 피노센브린, 사쿠라네틴, 이소사쿠라네틴, 피노반 쿠신, 아세틸피노반 쿠신 Flavanones : Pinostrobin, Pinosenbrine, Sacuranetin, Isosacuranetin, Pinovan Cousin, AcetylPinovan Cousin
스티르벤류: 프테로스티르벤Styrbene: Pterostilbene
기타: 비타민 A,B1,B2,H,E,P,DOther: Vitamin A, B 1 , B 2 , H, E, P, D
그리고 프로폴리스의 알려진 효능으로서는 박테리아의 증식억제 및 살균, 바이러스와 사상균의 살균, 트리코모나스 원충의 파괴, 진통, 항류마티스, 면역기능 증진, 식물의 발아 억제, 식물 바이러스의 성장저지, 산화방지 등이다.Known efficacies of propolis include the inhibition and sterilization of bacteria, the sterilization of viruses and filamentous fungi, the destruction of trichomonas protozoa, analgesic, antirheumatic, enhanced immune function, inhibition of plant germination, inhibition of plant virus growth, and prevention of oxidation.
또, 프로폴리스 효능의 종류로는 종양·곰팡이 기생·수충·피부병 및 화상·찰과상 치료용 각종 연고제 등의 원료로 쓰이는 의학적 효능과,In addition, the types of efficacy of propolis include medical effects used as raw materials, such as various ointments for the treatment of tumors, mold parasites, insects, skin diseases and burns, abrasions,
피부질한가 창상·감염증 치료·가시를 뽑은 후의 염증예방, 신경의 통증완화 등의 일반적 효능과, 구제병·유선염·브로셀라병·소화불량·제1,2도 화상·각종 출혈·상처의 반흔 형성·괴사균증 등의 치료에 사용하는 수의학적 효능 외에 화장비누·미용크림·샴푸·목욕용 비누·여드름 완화제 등의 화장품, 양초 등의 방향제, 고구마·감자 등의 농산물을 균류로부터 방어하기 위한 살포제 등의 농업적 효능 등이 있다.General effects such as skin irritation, wound healing, infection prevention, prevention of inflammation after pains are removed, nerve pain relief, salvation disease, mastitis, brosella disease, dyspepsia, first and second degree burns, various bleeding, scar formation In addition to the veterinary effects used in the treatment of necrosis, cosmetics such as cosmetic soap, beauty cream, shampoo, bath soap, acne relievers, fragrances such as candles, and sprays to protect agricultural products such as sweet potatoes and potatoes from fungi. Agricultural benefits.
프로폴리스의 의학적 효능의 구체적인 사례로서는 다음과 같은 것이 있다.Specific examples of the medical efficacy of propolis include the following.
이비인후과 질환: 화분증, 인후염, 비염, 부비강염, 이염Otolaryngology diseases: hay fever, sore throat, rhinitis, sinusitis, otitis
구강계 질환: 치통, 치주염, 치조농루, 설염Oral Diseases: Toothache, Periodontitis, Alveolar Fever, Sulphitis
소화기계 질환: 위염, 위궤양, 십이지장염, 대장염, 담낭염Digestive System Diseases: Gastritis, Gastric Ulcer, Duodenitis, Colitis, Cholecystitis
비뇨기계 및 생식기계 질환: 방광염, 신장염, 전립선 장애, 질트리코모나르증Urinary and reproductive diseases: cystitis, nephritis, prostate disorders, vaginal trichomoniasis
호흡기계 질환: 천식, 기관지염, 결핵Respiratory Diseases: Asthma, Bronchitis, Tuberculosis
심장 혈관계 및 순환기계 질환: 동맥경화증, 빈혈증Cardiovascular and circulatory diseases: arteriosclerosis, anemia
신경정신계 질환: 근육 스트로퍼, 파킨슨씨병, 병합 경화증, 뇌외상성증후군, 뇌혈관 질환, 신경성 식용부진Neuropsychiatric disorders: muscular streptor, Parkinson's disease, combined sclerosis, cerebral traumatic syndrome, cerebrovascular disease, anorexia nervosa
피부질환: 칼자국, 타박상, 화농, 동상, 치질, 피부각화 또는 경화, 사마귀, 켈로이드, 정맥류성 궤양, 라이나병, 습진, 건선, 누피백선증, 방사선 피부염Skin diseases: cuts, bruises, purulent, frostbite, hemorrhoids, keratinization or hardening, warts, keloids, varicose ulcers, lina disease, eczema, psoriasis, ringworm ringworm, radiation dermatitis
안질환: 염증, 안건염Eye diseases: inflammation, tendonitis
관절염: 류마티스 증후군Arthritis: Rheumatoid Syndrome
내분비계 질환: 갑상선 질염Endocrine Disease: Thyroid Vaginitis
본 발명은 이렇듯 많은 효능을 지녀서 특히 의약적 의료적으로도 폭넓게 쓰이는 유효 물질인 프로폴리스 5∼30%를 깨끗한 물(H2O) 95 ~ 70%와 혼합하여 구강 청결제로 한다.The present invention has such a large amount of efficacy, and in particular, medicinal and medically widely used 5-30% of the active substance propolis is mixed with 95% to 70% of clean water (H 2 O) as a mouthwash.
한편, 본 발명은 프로폴리스와 물(H2O)외에 필요에따라 다른 배합물즉, 불화나트륨(NaF)을 더 첨가할 수 있는데, 이때에는 프로폴리스 5%를 기준으로 불화나트륨 20%가 적당하고, 물은 75%로 하는 것이 효과적이다. 하지만, 상기 수치를 정설화 할 필요는 없고, 농도에 따라 배합 비율은 조정이 가능하다.On the other hand, in the present invention, in addition to the propolis and water (H 2 O), other combinations, such as sodium fluoride (NaF) may be further added as needed, in which case 20% sodium fluoride is suitable based on 5% propolis and For water, 75% is effective. However, it is not necessary to establish the numerical value, and the blending ratio can be adjusted according to the concentration.
벌집에서 채취할 수 있는 프로폴리스의 양은 매우 적은데 비해 수요가 워낙 많아 조달에 애로가 많고 따라서 시중 거래가는 상상을 초월할 정도로 높다. 또,프로폴리스의 1회 사용량도 증상에 따라 다소의 차이는 있지만 대체로 제한적이며, 각종 의약이나 의학적 치료제에는 미량 또는 극미량의 프로폴리스가 사용된다.The amount of propolis that can be harvested from the honeycomb is very small, but the demand is so high that it is difficult to procure, and the market price is higher than imagined. In addition, the amount of single use of propolis is somewhat limited depending on the symptoms, but is generally limited. Trace amounts or trace amounts of propolis are used for various medicines and medical treatments.
본 발명도 예외가 아니다. 프로폴리스의 사용량이 5%를 밑돌면 효험이 기대에 미치지 못하고 30% 이상 사용하면 채산성이 맞지 않는다.The present invention is not an exception. If the amount of propolis is less than 5%, the efficacy does not meet expectations, and if it is used more than 30%, the profitability is not correct.
위와 같이 자연 소독성과 치료효과가 검증된 프로폴리스 함유 구강 청결제는 잇틈과 잇틈측 잇몸에 기식하는 구강 세균까지도 멸균시킬 수 있고, 또 잇몸 질환을 비롯하여 치통, 치주염, 치조농루, 설염 등의 구강계 질환의 조기치유와 예방 효과를 제공하는 본 발명은 1회 사용으로 입안의 악취를 완전하게 제거하여 장시간동안 구강 청결상태를 유지할 수 있어 바쁜 직장인을 비롯한 출장지에서 효과적인 구강 청결제로 사용할 수 있고, 특히, 치염등의 치과계 염증으로 인한 고통이 수반되어 칫솔질을 할 수 없는 환자들이 양치질 이상의 효과를 제공하게 되므로, 국민건강에 이바지하게되는 매우 유용한 발명인 것이다.Propolis-containing oral cleansers with proven natural disinfection and therapeutic effects can sterilize oral bacteria that grow on gums and gums. The present invention provides an early healing and preventive effect of the present invention can completely remove the odor in the mouth to maintain the oral cleanliness for a long time can be used as an effective oral cleaning agent in business trips, including busy office workers, in particular, dentitis It is a very useful invention that contributes to the public health, because the pain caused by dental inflammation of the back accompanied by the brushing can not be brushed by patients.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20030085820A (en) * | 2002-05-02 | 2003-11-07 | 주식회사김정문알로에 | Oral composition containing extract of aloe and propolis |
| KR20030093891A (en) * | 2002-06-05 | 2003-12-11 | 김희성 | PROPOLIS Toothpaste COMPOSITION AND PROCESS FOR PREPARING THE SAME |
| KR100719306B1 (en) | 2004-11-04 | 2007-05-17 | 김희성 | Mouthwash Composition Containing Water Soluble Propolis Extract |
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