KR102485403B1 - Composition for strengthening nails and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a composition for strengthening nails to protect fingernails or toenails, including retinol-based derivatives, panthenol, biotin, dimethyl sulfone, and the like.

Description

Composition for strengthening nails and manufacturing method thereof}

The present invention relates to a composition for protecting nails, and more particularly, to a composition for strengthening nails containing a retinol-based derivative, panthenol, biotin, dimethyl sulfone and the like to protect nails or toenails.

In general, fingernails and toenails refer to translucent hard plate structures attached to the tips of fingers or toes. It is a dense collection of keratinized dead cells containing hard keratin, which helps the fingers perform functions such as protecting the fingers and picking up objects.

Fingernails and toenails contain hard keratin that is slightly curved and located on the dorsal surface of the fingers or toes, and are densely packed with keratinized dead cells without nuclei or organelles. The nail consists of the body of the nail, the base of the nail, the base of the nail, the matrix of the nail, the sheath above the nail, the sheath under the nail, and the crescent moon.

The visible part of the nail body is a translucent, hard, square-shaped plate that is slightly thicker on men's nails than on women's. The body of the nail descends below the level of the epithelium that surrounds it and covers a portion of the epidermis called the nail bed. The nail bed is located under the nail body and consists of a basal layer of the epidermis and an epithelial cell layer. As the nail body grows, it moves over the nail bed. Unless there is a special problem, it continues to grow throughout life and grows at a rate of about 3mm per month, but there are individual differences.

Keratinization and the constant replenishment of new cells at the nail root account for nail growth. The formation of the nail occurs at the root of the nail, which is embedded in folds of the epidermis that are not observed on the surface and covers the cells of the nail matrix. Nail matrix contains various cells such as stem cells, melanocytes, Merkel cells and Langerhans cells. Stem cells divide regularly and migrate toward the root of the nail, where they differentiate and produce keratin.

Fingernails and toenails are located on the dorsal surface of the fingers or toes and protect the fingertips from excessive twisting when subjected to physical force, such as when manipulating or holding something. Many predators of animals use claws, which are equivalent to fingernails, as weapons in the fight to defeat rivals, as well as to seize and subdue prey and tear apart prey.

In order for these nails to fulfill their functions and look aesthetically beautiful, it is necessary to properly maintain nail health.

Healthy-looking nails should be smooth, curved, unstained, and free of hollows or bumps. Nails in unhealthy conditions can be very detrimental to a person's image and, if left untreated, can lead to chronic infections associated with long term embarassment and pain. In particular, they can be regarded as social problems and/or occupational diseases.

Repetitive and prolonged wetting and drying of the nails is the single most common cause of nails splitting and bumps. Cracking of the nails rarely occurs due to medical disease or vitamin deficiency, and nail polish removers cause split nails (laminar splits), and eventually trauma to the fingers contributes to split nails.

Among the cosmetic damages to the nails may include breaking, splitting, fracturing, brittleness, white spots or ridges, poor nail growth, changes in color and shape, and the like. can

In order to solve the above problems, Korean Patent Registration No. 10-1140272 discloses nail reconstruction compositions for topical application, which include a) one or more genus Equisetum medicinal extracts, b) ) As a film forming agent, at least one component selected from hydroxyalkyl chitosans; wherein a) is in the form of a glycol extract, a pharmaceutical of topical application for the treatment or prevention of onychoschizia Regarding the composition, it is intended to provide a composition having good nail reconstruction, curing and strengthening effects.

However, the conventional nail reconstruction composition for topical application has a problem in that the effect is insignificant and does not show a clear effect on nail reconstruction, hardening and strengthening effects, and there is a growing need for a composition capable of strengthening nails more fundamentally.

Republic of Korea Patent Registration No. 10-1140272 (Announced on April 26, 2012), "Nail reconstruction compositions for topical application"

In order to solve the above problems, an object of the present invention is to provide a composition for strengthening nails to protect fingernails or toenails, including a retinol-based derivative, panthenol, biotin, dimethyl sulfone, and the like.

In order to solve the above problems, the present invention provides a nail strengthening composition comprising a retinol-based derivative and dimethyl sulfone, and further comprising at least one of panthenol and biotin.

In addition, the present invention provides a nail strengthening composition comprising all of the retinol-based derivative, dimethyl sulfone, panthenol, and biotin.

In addition, the present invention includes the retinol-based derivative, panthenol, biotin and dimethyl sulfone, polyglyceryl-2 dipolyhydroxystearate, caprylic/capric triglyceride, cera alba, zinc stearate, Strengthening nails characterized by further comprising jojoba seed oil, hexyllaurate, shea butter, cyclopentasiloxane, cyclohexasiloxane, dimethicone, purified water, glycerin, disodium EDTA, allantoin and phenoxyethanol. A composition for

In addition, the present invention includes the retinol-based derivative, panthenol, biotin and dimethyl sulfone, purified water, glycerin, sucrose laurate, sucrose myristate, denatured alcohol, olive oil, sunflower seed oil, cacao seed butter, shea butter, It provides a composition for strengthening nails, characterized in that it further comprises grape seed oil, rosemary oil and lime peel oil.

In addition, the present invention includes the retinol-based derivative, panthenol, biotin and dimethyl sulfone, purified water, ethylhexyl glycerin, potassium bait, denatured alcohol, polyurethane-1, polyurethane-34, acrylate copolymer, tocopherol, Provided is a composition for strengthening nails, further comprising caprylyl glycol, PEG-12 dimethicone, methylpropanediol and phenylpropanol.

The composition for strengthening nails according to the present invention includes a retinol-based derivative, panthenol, biotin, and dimethyl sulfone, and has an effect of protecting nails or toenails.

1 is a graph comparing the thicknesses of left nails coated with Examples 1 to 3 and Comparative Examples 1 to 6 and right nails uncoated.
2 is a graph showing changes in roughness of nails coated with Examples 1 to 3 and Comparative Examples 1 to 6;
3 is a graph showing changes in hardness of nails coated with Examples 1 to 3 and Comparative Examples 1 to 6;
Figure 4 is a graph comparing the length growth of the left nail coated with Examples 1 to 3 and Comparative Examples 1 to 6 and the right nail without any coating.

The detailed description of the present invention below refers to the accompanying drawings shown as examples of embodiments in which the present invention can be practiced. These embodiments are described in detail so that those skilled in the art will be able to practice the present invention. It should be understood that the various embodiments of the present invention are different, but need not be mutually exclusive. For example, specific shapes, structures, and characteristics described herein may be implemented in one embodiment in another embodiment without departing from the spirit and scope of the invention. Additionally, it should be understood that the location or arrangement of individual components within each described embodiment may be changed without departing from the spirit and scope of the invention.

Accordingly, the detailed description set forth below is not to be taken in a limiting sense, and the scope of the present invention, if properly described, is limited only by the appended claims, along with all equivalents as claimed by those claims. Like reference numbers in the drawings indicate the same or similar function throughout the various aspects.

The terms used in the present invention have been selected from general terms that are currently widely used as much as possible while considering the functions in the present invention, but these may vary depending on the intention of a person skilled in the art or precedent, the emergence of new technologies, and the like. In addition, in a specific case, there is also a term arbitrarily selected by the applicant, and in this case, the meaning will be described in detail in the description of the invention. Therefore, the term used in the present invention should be defined based on the meaning of the term and the overall content of the present invention, not simply the name of the term.

In the present invention, when a part "includes" a certain component, it means that it may further include other components, not excluding other components, unless otherwise stated.

Hereinafter, the composition for strengthening nails according to the present invention will be described in detail.

The composition for strengthening nails according to the present invention basically includes a retinol-based derivative and dimethyl sulfone, and may further include at least one of panthenol and biotin.

In the present invention, the term retinol-based derivatives refers to retinol and all derivatives derived from retinol. Most basically, retinol is appropriate, but since retinol derivatives also have properties similar to those of retinol, it is safe to assume that they can exhibit the same or similar effects as retinol.

The retinol (retinol) is one kind of vitamin A. The retinol plays an important role in maintaining the original function of epidermal cells of the skin. To be exact, it is the chemical name for vitamin A1, also known as pure vitamin A. It is present in the intestinal mucosal cells of animals and is abundant in greenish-yellow plants. It is also transformed into an active form, retinoic acid, and is known to play an important role in maintaining the original function of epidermal cells. In other words, DNA in the cell nucleus present in skin cells promotes cell differentiation by expressing RNA, promoting the biosynthesis of collagen, a light protein that exists as a fibrous solid between animal cells, and elastin composed of elastic fibers, resulting in wrinkles. It is known to have the effect of reducing the skin and increasing skin elasticity.

Meanwhile, retinol-based derivatives may include retinol, retinyl retinoate, retinyl acetate, retinyl propionate, retinyl linoleate, retinyl oleate, retinyl tolate, and retinaldehyde.

The panthenol is an alcohol derivative of pantothenic acid and is a long-acting pantothenic acid agent. It is oxidized in vivo to become pantothenic acid and is effective. This drug has the action of accelerating the production of acetylcholine, and is particularly used for the treatment of chronic constipation as a bowel movement promoter. As a skin softener, skin moisturizer, skin conditioning agent, and antistatic agent derived from water-soluble vitamin Vit B5, it is a humectant with strong moisturizing power and affects the regeneration of skin cells along with moisturizing. Moisturizing power and skin penetration are both good, but the texture is heavy.

The biotin (biotin), also called coenzyme R7, is a colorless water-soluble essential vitamin necessary for normal growth and function of the body. Biotin not only acts as an essential cofactor in the regulation of enzyme activity and gene expression in metabolic processes, but also is involved in gluconeogenesis, fatty acid biosynthesis, protein metabolism and gene expression regulation. Biotin is a vitamin containing sulfur (S) that is soluble in water and alcohol, and is relatively stable to heat or light, but decomposes when heated in an acidic or alkaline aqueous solution for a long time.

The dimethyl sulfone (dimethyl sulfone) is also called MSM (Methyl Sulfoneyl Methane) as a natural organic sulfur. In general, sulfur is an essential substance for constituting the cells of our body, and the dimethyl sulfone helps maintain healthy cartilage by providing sulfur necessary for joint health. The dimethyl sulfone relieves joint pain and reduces inflammation and pain associated with rheumatism or tendons. Sulfur, commonly known as inorganic sulfur, is a yellow substance mixed with various solid and liquid substances, but dimethyl sulfone and inorganic sulfur are completely different. The dimethyl sulfone can be extracted from by-products produced in the process of making pulp from pine trees, and the sulfur component is 34%, which is one of the most sulfur-containing substances in nature.

The present invention was completed by confirming that the strengthening effect on the nail is improved by the interaction between the components including a retinol-based derivative, panthenol, biotin and dimethyl sulfone at the same time.

The composition for strengthening nails according to the present invention includes retinol-based derivatives, panthenol, biotin, and dimethyl sulfone at the same time, and includes retinol-based derivatives alone, panthenol alone, and biotin alone. It was confirmed that the efficacy was improved when retinol-based derivatives, panthenol, biotin, and dimethyl sulfone were simultaneously included, compared to when only methyl sulfone was included.

This is due to the interaction between the retinol-based derivatives, panthenol, biotin, and dimethyl sulfone components, and since it is unexpected, it will be considered novel.

Meanwhile, the composition for strengthening nails according to the present invention includes 0.05 to 1.0% by weight of the retinol derivative, 0.05 to 5.0% by weight of the panthenol, 0.1 to 3.0% by weight of the biotin, and 0.1 to 3.0% by weight of the dimethyl sulfone. It will be appropriate to include 0.5 to 5.0% by weight of silver.

More specifically, the composition for strengthening nails according to the present invention contains 0.1% by weight of the retinol derivative, 0.3% by weight of the panthenol, 0.2% by weight of the biotin, and 1.0% by weight of the dimethyl sulfone. Inclusion would be most desirable.

The composition for strengthening nails according to the present invention is most effective when it contains all of retinol-based derivatives, dimethyl sulfone, panthenol, and biotin.

Thus, the composition for strengthening nails according to the present invention may contain all of retinol-based derivatives, dimethyl sulfone, panthenol, and biotin.

Meanwhile, the composition of the present invention may be provided in the form of a nail care cream.

To this end, the present invention includes the retinol-based derivative, panthenol, biotin and dimethyl sulfone, polyglyceryl-2 dipolyhydroxystearate, caprylic/capric triglyceride, cera alba, zinc stearate, A nail characterized by further comprising jojoba seed oil, hexyllaurate, shea butter, cyclopentasiloxane, cyclohexasiloxane, dimethicone, purified water, glycerin, disodium EDTA, allantoin and phenoxyethanol. A composition for strengthening is provided.

In other words, the present invention relates to retinol derivatives, panthenol, biotin dimethyl sulfone, polyglyceryl-2 dipolyhydroxystearate, caprylic/capric triglyceride, sera alba, zinc stearate, jojoba seed oil, Provided is a nail care cream composition for strengthening nails containing hexyllaurate, shea butter, cyclopentasiloxane, cyclohexasiloxane, dimethicone, purified water, glycerin, disodium EDTA, allantoin and phenoxyethanol.

The nail care cream composition for strengthening nails according to an embodiment of the present invention contains polyglyceryl-2 dipolyhydroxystearate, caprylic/capric triglyceride, cera alba, zinc stearate, jojoba seed oil, and hexylau. A mixture consisting of latex, shea butter, cyclopentasiloxane, cyclohexasiloxane, dimethicone and retinol derivatives, purified water, glycerin, disodium EDTA, allantoin, phenoxyethanol, biotin, panthenol, and dimethylsulfone. Each of the resulting mixtures is heated to 85 ° C, and when each mixture is at the same temperature, polyglyceryl-2 dipolyhydroxystearate, caprylic / capric triglyceride, cera alba, zinc stearate, jojoba seed oil , hexyllaurate, shea butter, cyclopentasiloxane, cyclohexasiloxane, dimethicone and retinol derivatives, purified water, glycerin, disodium EDTA, allantoin, phenoxyethanol, biotin, panthenol, dimethicone It is characterized in that a mixture consisting of methyl sulfone was added, mixed vigorously, and cooled to 35 ° C. In the process of forming the emulsion, it is preferable to use a vacuum.

Meanwhile, the composition of the present invention may be provided in the form of a nail balm/oil.

To this end, the present invention includes the retinol derivative, panthenol, biotin and dimethyl sulfone, purified water, glycerin, sucrose laurate, sucrose myristate, denatured alcohol, olive oil, sunflower seed oil, cacao seed butter, shea butter, It provides a composition for strengthening nails, characterized in that it further comprises grape seed oil, rosemary oil and lime peel oil.

In other words, the present invention is a retinol derivative, panthenol, biotin dimethyl sulfone, purified water, glycerin, sucrose laurate, sucrose myristate, denatured alcohol, olive oil, sunflower seed oil, cacao seed butter, shea butter, grape seed oil, rosemary A nail balm/oil composition for strengthening nails comprising oil and lime peel oil is provided.

A nail balm/oil composition for strengthening nails according to an embodiment of the present invention is obtained by mixing purified water, glycerin, sucrose laurate, sucrose myristate, denatured alcohol, biotin, panthenol, and dimethylsulfone while heating to 70°C, Olive oil, sunflower seed oil, cacao seed butter, shea butter, grape seed oil and a retinol derivative were added to a mixture of heated purified water, glycerin, sucrose laurate, sucrose myristate, denatured alcohol, biotin, panthenol and dimethyl sulfone, It is characterized by slowly mixing until a gel form is observed, cooling to room temperature, adding rosemary oil and lime peel oil and mixing slowly.

Meanwhile, the composition of the present invention may be provided in the form of a nail care film.

To this end, the present invention includes the retinol-based derivative, panthenol, biotin and dimethyl sulfone, purified water, ethylhexyl glycerin, potassium bait, denatured alcohol, polyurethane-1, polyurethane-34, acrylate copolymer, tocopherol, A composition for strengthening nails containing caprylyl glycol, PEG-12 dimethicone, methylpropanediol and phenylpropanol is provided.

In other words, the present invention is a retinol derivative, panthenol, biotin dimethyl sulfone, purified water, ethylhexylglycerin, potassiumbate, denatured alcohol, polyurethane-1, polyurethane-34, acrylate copolymer, tocopherol, caprylyl glycol Provided is a nail care film composition for strengthening nails containing kohl, PEG-12 dimethicone, methylpropanediol and phenylpropanol.

In the nail care film composition for strengthening nails according to an embodiment of the present invention, purified water, ethylhexylglycerin, potassium bete, biotin, panthenol, and dimethylsulfone are mixed and dissolved at room temperature, and denatured alcohol, polyurethane-1, poly Mix and dissolve urethane-34, acrylate copolymer, tocopherol and retinol derivatives, and mix and dissolve caprylyl glycol, PEG-12 dimethicone, methylpropanediol and phenylpropanol at room temperature. It is characterized in that parts A, B, and C are all mixed and dissolved and then filtered.

Hereinafter, the effects of the composition for strengthening nails according to the present invention will be described in more detail through the following Examples, Comparative Examples, and Experimental Examples.

Example 1. of the present invention in the examples Preparation of a composition for strengthening nails according to

A composition comprising retinol, panthenol, biotin and dimethyl sulfone was prepared. A mixture was prepared with 0.1 wt% of retinol, 0.3 wt% of panthenol, 0.2 wt% of biotin, and 1.0 wt% of dimethyl sulfone and the remaining amount as purified water.

comparative example 1. Preparation of a composition containing only retinol

A mixture was prepared by adding purified water to 0.1% by weight of retinol.

comparative example 2. only panthenol Preparation of a composition comprising

A mixture was prepared with 0.3% by weight of panthenol and the remaining amount as purified water.

comparative example 3. biotin only Preparation of a composition comprising

A mixture was prepared with 0.2% by weight of biotin and the remaining amount as purified water.

comparative example 4. dimethyl sulfone only Preparation of a composition comprising

A mixture was prepared by adding 1.0% by weight of dimethyl sulfone to the remaining amount of purified water.

Example 2. As a retinol derivative retinyl retinoate Preparation of used nail strengthening composition

As another example of the retinol-based derivative, a composition for strengthening nails was prepared by applying retinyl retinoate. It was prepared in the same manner as in Example 1, except that retinol was changed to retinyl retinoate.

A composition comprising retinyl retinoate, panthenol, biotin and dimethyl sulfone was prepared. Retinyl retinoate was 0.1 wt%, panthenol 0.3 wt%, biotin 0.2 wt%, and dimethyl sulfone 1.0 wt%, and the remaining amount was purified water to prepare a mixture.

comparative example 5. only Retinyl Retinoate Preparation of a composition comprising

For comparison with Example 2, a mixture was prepared by adding purified water to 0.1% by weight of retinyl retinoate.

Example 3. As a retinol derivative retinyl acetate Preparation of used nail strengthening composition

As another example of the retinol-based derivative, retinyl acetate was applied to prepare a composition for strengthening nails. It was prepared in the same manner as in Example 1, but by changing retinol to retinyl acetate.

A composition containing retinyl acetate, panthenol, biotin and dimethyl sulfone was prepared. Retinyl acetate was 0.1 wt%, panthenol 0.3 wt%, biotin 0.2 wt%, and dimethyl sulfone 1.0 wt%, and the remaining amount was purified water to prepare a mixture.

comparative example 6. only retinyl acetate Preparation of a composition comprising

For comparison with Example 3, a mixture was prepared by adding purified water to 0.1% by weight of retinyl acetate.

manufacturing example 1 to 7. Nails for nail strengthening Care preparation of cream

Nail care creams of Preparation Examples 1 to 7 were prepared according to the composition ratios in Table 1 below.

part ingredient Preparation Example 1 Preparation Example 2 Preparation Example 3 Production Example 4 Preparation Example 5 Preparation Example 6 Preparation Example 7 A Polyglyceryl-2-dipolyhydroxystearate 5 5 5 5 5 5 5 caprylyl/capric triglyceride 6 6 6 6 6 6 6 Sarah Alba 0.5 0.5 0.5 0.5 0.5 0.5 0.5 zinc stearate 0.5 0.5 0.5 0.5 0.5 0.5 0.5 jojoba seed oil 5 5 5 5 5 5 5 Hexylaurate 4 4 4 4 4 4 4 shea butter 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Cyclopentasiloxane One One One One One One One Cyclohexasiloxane One One One One One One One dimethicone 2 2 2 2 2 2 2 retinol 0.1 0.05 0.05 0.05 0 0 0 B Purified water balance balance balance balance balance balance balance glycerin 5 5 5 5 5 5 5 Disodium EDT 0.1 0.1 0.1 0.1 0.1 0.1 0.1 allantoin 0.3 0.3 0.3 0.3 0.3 0.3 0.3 phenoxyethanol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 biotin 0.2 0.2 0 0.2 0.2 0.2 0 panthenol 0.3 0.3 0 0.3 0.3 0.3 0 Dimethylsulfone 1.0 0.5 0.5 0 0.5 0 0 total 100 100 100 100 100 100 100

Part A and Part B were heated to 85° C., and when both parts were heated to the same temperature, Part B was poured into Part A and mixed vigorously. Cool to 35° C. while mixing. In the process of forming the emulsion, a nail care cream was prepared using a vacuum.

manufacturing example 8 to 14. Preparation of nail/balm oil for nail strengthening

Nail/balm oils of Preparation Examples 8 to 14 were prepared according to the composition ratios in Table 2 below.

part ingredient Preparation Example 8 Production Example 9 Production Example 10 Preparation Example 11 Production Example 12 Preparation Example 13 Production Example 14 A Purified water 20 20 20 20 20 20 20 glycerin 10 10 10 10 10 10 10 Sucrose Laurate 4 4 4 4 4 4 4 sucrose myristate 6 6 6 6 6 6 6 denatured alcohol 5 5 5 5 5 5 5 biotin 0.2 0.2 0 0.2 0.2 0.2 0 panthenol 0.3 0.3 0 0.3 0.3 0.3 0 Dimethylsulfone 1.0 0.5 0.5 0 0.5 0 0 B olive oil balance balance balance balance balance balance balance sunflower seed oil 20 20 20 20 20 20 20 Cocoa Seed Butter 2 2 2 2 2 2 2 shea butter 8 8 8 8 8 8 8 grapeseed oil 5 5 5 5 5 5 5 retinol 0.1 0.05 0.05 0.05 0 0 0 C rosemary leaf extract 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Lime Peel Oil 0.5 0.5 0.5 0.5 0.5 0.5 0.5 total 100 100 100 100 100 100 100

Part A was mixed while heating to 70 °C. Part B was added to Part A heated to 70° C. and mixed slowly. After mixing until a gel form was observed and cooled to room temperature, Part C was added and mixed slowly to prepare a nail/balm oil.

manufacturing example 15 to manufacturing example 21. Toenail Strengthening Nails Care manufacture of film

Nail care films of Preparation Examples 15 to 21 were prepared according to the composition ratios in Table 3 below.

part ingredient Production Example 15 Production Example 16 Production Example 17 Preparation Example 18 Production Example 19 Production Example 20 Production Example 21 A Purified water balance balance balance balance balance balance balance Ethylhexylglycerin 0.5 0.5 0.5 0.5 0.5 0.5 0.5 potassium sorbate 0.5 0.5 0.5 0.5 0.5 0.5 0.5 biotin 0.2 0.2 0 0.2 0.2 0.2 0 panthenol 0.3 0.3 0 0.3 0.3 0.3 0 Dimethylsulfone 1.0 0.5 0.5 0 0.5 0 0 B denatured alcohol 5 5 5 5 5 5 5 Polyurethane-1 15 15 15 15 15 15 15 Polyurethane-34 2 2 2 2 2 2 2 Acrylate Copolymer 0.5 0.5 0.5 0.5 0.5 0.5 0.5 tocopherol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 retinol 0.1 0.05 0.05 0.05 0 0 0 C capryl glycol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 PEG-12 Dimethicone 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Methyl Propanediol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 phenylpropanol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 total 100 100 100 100 100 100 100

Part A was mixed and dissolved at room temperature. In addition, Part B was mixed and dissolved at room temperature. In addition, Part C was mixed and dissolved at room temperature.

Parts A, B, and C were all mixed and dissolved at room temperature, and then filtered to prepare a nail care film.

Preparation Examples 1 to 21 differ only in the contents of retinol, panthenol, biotin, and dimethyl sulfone, and since the other contents are the same, effects according to differences in contents of retinol, panthenol, biotin, and dimethyl sulfone can be compared.

Experimental example 1. Evaluation of nail thickness

From the starting point of the translucent free edge of the nail, the experiment was conducted on the width X length (9 X 9 mm) of the center of the free edge of the nail, taking into consideration the upward, downward, left, and right curvature and natural damage.

After selecting 50 test subjects, disinfecting their nails, pushing up the cuticles and causing damage by filing, the compositions of Example 1 and Comparative Examples 1 to 4 and Preparation Examples 1 to 21 were applied to the left pup, respectively. It was applied to the fingernails. Immediately before application and 90 days after application, nail thickness was measured using vernier calipers and differences were compared.

The results of measuring nail thickness after 90 days are shown in the table below. The following table compares the thickness changes of left fingernails and right fingernails to which the compositions of Example 1 and Comparative Examples 1 to 4 and Preparation Examples 1 to 21 were applied.

Thickness (mm, average) of the left nail to which the composition was applied after 90 days After 90 days, the thickness of the right nail without the application of the composition (mm, average) Thickness difference between left and right nails (mm) Example 1 0.38 ± 0.03 0.32 ± 0.03 0.06 Comparative Example 1 0.33 ± 0.01 0.32 ± 0.02 0.01 Comparative Example 2 0.34 ± 0.02 0.32 ± 0.03 0.02 Comparative Example 3 0.33 ± 0.03 0.32 ± 0.02 0.01 Comparative Example 4 0.33 ± 0.02 0.32 ± 0.01 0.01 Example 2 0.37 ± 0.01 0.32 ± 0.02 0.05 Comparative Example 5 0.33 ± 0.02 0.32 ± 0.03 0.01 Example 3 0.37 ± 0.01 0.32 ± 0.02 0.05 Comparative Example 6 0.33 ± 0.01 0.32 ± 0.01 0.01

Thickness (mm, average) of the left nail to which the composition was applied after 90 days After 90 days, the thickness of the right nail without the application of the composition (mm, average) Thickness difference between left and right nails (mm) Preparation Example 1 0.36 ± 0.02 0.32 ± 0.02 0.04 Preparation Example 2 0.35 ± 0.02 0.32 ± 0.03 0.03 Preparation Example 3 0.34 ± 0.01 0.32 ± 0.01 0.02 Production Example 4 0.34 ± 0.03 0.32 ± 0.03 0.02 Preparation Example 5 0.33 ± 0.02 0.32 ± 0.02 0.01 Preparation Example 6 0.33 ± 0.01 0.32 ± 0.03 0.01 Preparation Example 7 0.33 ± 0.02 0.32 ± 0.02 0.01

Thickness (mm, average) of the left nail to which the composition was applied after 90 days After 90 days, the thickness of the right nail without the application of the composition (mm, average) Thickness difference between left and right nails (mm) Preparation Example 1 0.37 ± 0.003 0.32 ± 0.03 0.05 Preparation Example 2 0.36 ± 0.001 0.32 ± 0.02 0.04 Preparation Example 3 0.34 ± 0.003 0.32 ± 0.01 0.02 Production Example 4 0.33 ± 0.003 0.32 ± 0.02 0.01 Preparation Example 5 0.33 ± 0.002 0.32 ± 0.03 0.01 Preparation Example 6 0.33 ± 0.003 0.32 ± 0.01 0.01 Preparation Example 7 0.33 ± 0.001 0.32 ± 0.02 0.01

Thickness (mm, average) of the left nail to which the composition was applied after 90 days After 90 days, the thickness of the right nail without the application of the composition (mm, average) Thickness difference between left and right nails (mm) Preparation Example 1 0.37 ± 0.003 0.32 ± 0.02 0.05 Preparation Example 2 0.35 ± 0.002 0.32 ± 0.02 0.03 Preparation Example 3 0.34 ± 0.003 0.32 ± 0.03 0.02 Production Example 4 0.34 ± 0.002 0.32 ± 0.01 0.02 Preparation Example 5 0.34 ± 0.002 0.32 ± 0.01 0.02 Preparation Example 6 0.34 ± 0.001 0.32 ± 0.02 0.02 Preparation Example 7 0.33 ± 0.003 0.32 ± 0.01 0.01

As a result, it was confirmed that the thickness increased the most when all of retinol, panthenol, biotin, and dimethyl sulfone were included.

Experimental example 2. Evaluation of nail roughness

From the starting point of the translucent free edge of the nail, the experiment was conducted on the width X length (9 X 9 mm) of the center of the free edge of the nail, taking into consideration the upward, downward, left, and right curvature and natural damage.

After selecting 50 test subjects, disinfecting their nails, pushing up the cuticles and causing damage by filing, the compositions of Example 1 and Comparative Examples 1 to 4 and Preparation Examples 1 to 21 were applied to the left little finger, respectively. applied to the nails. Nail roughness was measured by CLSM. CLSM is an optical microscope most suitable for capturing the three-dimensional structure of a sample. It focuses laser light on one point on the sample and reads the color or brightness information at that point. By scanning the entire sample, the sample is scanned. Information on all the points constituting the can be obtained. After profiling in the X and Y axis directions, each roughness value (Ra) is measured to quantify the damage value, and based on these data, if you visualize it using a computer, you can obtain a 2D or 3D image. Laser light penetrates the sample and even the roughness of the surface and section can be measured.

The results of measuring the nail roughness values after 90 days are shown in the table below. The table below shows changes in roughness values of left fingernails to which the compositions of Example 1 and Comparative Examples 1 to 4 and Preparation Examples 1 to 21 were applied. The measurement result was expressed as a roughness value (Ra) measured and given by the device.

Roughness value before application (Ra) Roughness value after 90 days (Ra) Example 1 3.17 2.18 Comparative Example 1 3.16 2.88 Comparative Example 2 3.18 2.78 Comparative Example 3 3.17 2.84 Comparative Example 4 3.14 2.68 Example 2 3.17 2.20 Comparative Example 5 3.16 2.89 Example 3 3.16 2.21 Comparative Example 6 3.17 2.91

Roughness value before application (Ra) Roughness value after 90 days (Ra) Preparation Example 1 3.16 2.27 Preparation Example 2 3.15 2.45 Preparation Example 3 3.14 2.82 Production Example 4 3.17 2.85 Preparation Example 5 3.18 2.89 Preparation Example 6 3.17 2.92 Preparation Example 7 3.16 3.09

Roughness value before application (Ra) Roughness value after 90 days (Ra) Preparation Example 8 3.15 2.29 Preparation Example 9 3.15 2.47 Production Example 10 3.16 2.82 Preparation Example 11 3.14 2.84 Production Example 12 3.17 2.89 Preparation Example 13 3.15 2.96 Production Example 14 3.13 3.10

Roughness value before application (Ra) Roughness value after 90 days (Ra) Production Example 15 3.14 2.31 Production Example 16 3.16 2.51 Production Example 17 3.16 2.79 Preparation Example 18 3.15 2.83 Production Example 19 3.13 2.91 Production Example 20 3.17 2.96 Production Example 21 3.14 3.13

As a result, it was confirmed that the roughness value of the nail was reduced the most when all of retinol, panthenol, biotin, and dimethyl sulfone were included.

Experimental example 3. Evaluation of nail hardness

From the starting point of the translucent free edge of the nail, the experiment was conducted on the width X length (9 X 9 mm) of the center of the free edge of the nail, taking into consideration the upward, downward, left, and right curvature and natural damage.

Fifty test subjects were selected and the compositions of Example 1 and Comparative Examples 1 to 4 and Preparation Examples 1 to 21 were applied to the nail of the left little finger, respectively. A square weight diamond indenter with a facing angle of 136 ° was pressed against the test surface under a constant test load of 0.1 kg or less, and the hardness of the sample was determined with a micro Vickers hardness tester from the load at that time and the area ratio of the concave area formed in the nail.

* Hv = P/A P: load, A: surface area of indentation

The results of measuring nail hardness after 90 days are shown in the table below. The table below shows changes in the hardness of the fingernails of the left fingers to which the compositions of Example 1 and Comparative Examples 1 to 4 and Preparation Examples 1 to 21 were applied. The measurement results were expressed as Hv values according to the above calculation formula.

Hardness before application (Hv) Hardness after 90 days (Hv) Example 1 13.43 29.39 Comparative Example 1 13.42 18.28 Comparative Example 2 13.41 19.32 Comparative Example 3 13.42 17.39 Comparative Example 4 13.43 15.46 Example 2 13.42 28.37 Comparative Example 5 13.42 18.34 Example 3 13.43 28.32 Comparative Example 5 13.41 18.24

Hardness before application (Hv) Hardness after 90 days (Hv) Preparation Example 1 13.42 26.72 Preparation Example 2 13.43 24.83 Preparation Example 3 13.43 23.95 Production Example 4 13.42 23.33 Preparation Example 5 13.42 22.56 Preparation Example 6 13.41 21.97 Preparation Example 7 13.43 14.54

Hardness before application (Hv) Hardness after 90 days (Hv) Preparation Example 8 13.41 25.67 Production Example 9 13.43 23.33 Production Example 10 13.42 21.69 Preparation Example 11 13.42 21.32 Production Example 12 13.43 20.85 Preparation Example 13 13.42 20.41 Production Example 14 13.41 15.22

Hardness before application (Hv) Hardness after 90 days (Hv) Production Example 15 13.43 27.32 Production Example 16 13.42 24.78 Production Example 17 13.41 23.62 Preparation Example 18 13.43 22.49 Production Example 19 13.42 22.33 Production Example 20 13.43 22.13 Production Example 21 13.41 15.09

As a result, it was confirmed that hardness increased the most when all of retinol, panthenol, biotin, and dimethyl sulfone were included.

Experimental example 4. Evaluate nail length growth effect

Fifty test subjects were selected and the compositions of Example 1 and Comparative Examples 1 to 4 and Preparation Examples 1 to 21 were applied to the fingernails of the left little finger, respectively, and a dressing film for wound treatment was applied before going to bed (left : experimental group, right: control group). During the experiment period, application was carried out at intervals of once a day. Immediately before application and 90 days after application, the growth length of the nail was measured and the difference was compared.

Growth length of the left nail to which the composition was applied after 90 days (mm, average) After 90 days, the growth length of the right nail without the application of the composition (mm, average) Difference in growth length between left and right nails (mm) Example 1 12.3 9.2 3.1 Comparative Example 1 10.2 9.3 0.9 Comparative Example 2 10.1 9.2 0.9 Comparative Example 3 9.8 9.2 0.6 Comparative Example 4 9.6 9.3 0.3 Example 2 11.8 9.1 2.7 Comparative Example 5 10.3 9.3 1.0 Example 3 11.9 9.2 2.7 Comparative Example 6 10.1 9.2 0.9

Growth length of the left nail to which the composition was applied after 90 days (mm, average) After 90 days, the growth length of the right nail without the application of the composition (mm, average) Difference in growth length between left and right nails (mm) Preparation Example 1 11.9 9.2 2.7 Preparation Example 2 11.1 9.3 1.8 Preparation Example 3 10.4 9.4 1.0 Production Example 4 10.2 9.2 1.0 Preparation Example 5 9.9 9.2 0.7 Preparation Example 6 9.4 9.1 0.3 Preparation Example 7 9.3 9.2 0.1

Growth length of the left nail to which the composition was applied after 90 days (mm, average) After 90 days, the growth length of the right nail without the application of the composition (mm, average) Difference in growth length between left and right nails (mm) Preparation Example 8 11.7 9.1 2.6 Production Example 9 10.9 9.3 1.6 Production Example 10 10.2 9.2 1.0 Preparation Example 11 9.8 9.2 0.6 Production Example 12 9.6 9.3 0.3 Preparation Example 13 9.5 9.2 0.3 Production Example 14 9.3 9.2 0.1

Growth length of the left nail to which the composition was applied after 90 days (mm, average) After 90 days, the growth length of the right nail without the application of the composition (mm, average) Difference in growth length between left and right nails (mm) Production Example 15 11.8 9.3 2.5 Production Example 16 11.2 9.3 1.9 Production Example 17 10.5 9.2 1.3 Preparation Example 18 10.2 9.3 0.9 Production Example 19 9.8 9.2 0.6 Production Example 20 9.5 9.2 0.3 Production Example 21 9.2 9.1 0.1

As a result, it was confirmed that the length growth effect of the ton was most excellent when all of retinol, panthenol, biotin, and dimethyl sulfone were included.

conclusion.

Through the above Examples, Comparative Examples, Preparation Examples and Experimental Examples, the effect of the composition for strengthening nails according to the present invention was confirmed.

First, through Experimental Example 1, when Example 1 containing all of retinol, panthenol, biotin, and dimethyl sulfone was applied to the cut nail, the thickness of the nail increased compared to the case where Comparative Examples 1 to 4 were applied. I was able to confirm. Also, in Preparation Examples, Preparation Examples 1, 8, and 15 containing all of retinol, panthenol, biotin, and dimethyl sulfone were found to increase the nail thickness more than the rest.

In addition, through Experimental Example 2, when Example 1 containing all of retinol, panthenol, biotin, and dimethyl sulfone was applied to artificially damaged nails, the roughness value decreased compared to the case of Comparative Examples 1 to 4. could confirm that In addition, even in Preparation Examples, it was confirmed that Preparation Examples 1, 8, and 15 containing all of retinol, panthenol, biotin, and dimethyl sulfone had a more reduced roughness value than the rest.

In addition, through Experimental Example 3, when Example 1 containing all of retinol, panthenol, biotin, and dimethyl sulfone was applied to artificially damaged nails, the hardness increased compared to the case of Comparative Examples 1 to 4. I was able to confirm. In addition, even in Preparation Examples, it was confirmed that Preparation Examples 1, 8, and 15 containing all of retinol, panthenol, biotin, and dimethyl sulfone had higher hardness than the others.

In addition, through Experimental Example 4, when Example 1 containing all of retinol, panthenol, biotin, and dimethyl sulfone was applied to the nail, it was confirmed that the length growth of the nail was accelerated compared to the case where Comparative Examples 1 to 4 were applied. could Also, in Preparation Examples, Preparation Examples 1, 8, and 15 containing all of retinol, panthenol, biotin, and dimethyl sulfone were confirmed to promote nail length growth more than the rest.

On the other hand, similar results were obtained when retinyl retinoate and retinyl acetate were applied in addition to retinol as retinol derivatives (Examples 2 to 3 and Comparative Examples 5 to 6). Through this, other retinol derivatives other than retinol It was also inferred that the same or similar effect appeared.

That is, it was confirmed that the composition for strengthening nails according to the present invention has an effect of increasing thickness, improving roughness, and increasing hardness for artificially damaged nails, and promotes nail length growth. In addition, this may be applied to claws in the same way. All of the above effects are related to the health of nails, and the composition for strengthening nails according to the present invention will have a repair effect on damaged nails or toenails.

Therefore, the present invention specifies that a composition for strengthening nails has been developed as a novel composition having an effect of increasing thickness, improving roughness, increasing hardness, and promoting effect of length growth on damaged nails.

Although the present invention has been described with the accompanying drawings, this is only one example of various embodiments including the gist of the present invention, and is intended to be easily practiced by those skilled in the art. As an object, it is clear that the present invention is not limited to the embodiments described above. Therefore, the protection scope of the present invention should be interpreted by the following claims, and all technical ideas within the equivalent range by change, substitution, substitution, etc. within the scope of the present invention do not depart from the scope of the present invention. will be included In addition, it is clear that some configurations in the drawings are provided exaggerated or reduced than the actual configuration to more clearly explain the configuration.

Claims (7)

All of the retinol-based derivatives, dimethyl sulfone, panthenol, and biotin at the same time 0.05 to 1.0% by weight of the retinol derivative, 0.05 to 5.0% by weight of the panthenol, 0.1 to 3.0% by weight of the biotin, and 0.5 to 5.0% by weight of the dimethyl sulfone A composition for strengthening nails, characterized in that.
According to claim 1,
The retinol-based derivative is a composition for strengthening nails, characterized in that any one of retinol, retinyl retinoate, retinyl acetate, retinyl propionate, retinyl linoleate, retinyl oleate, retinyl tolate or retinaldehyde. .
delete delete According to claim 1,
Including the retinol-based derivative, panthenol, biotin and dimethyl sulfone,
Polyglyceryl-2 dipolyhydroxystearate, caprylic/capric triglyceride, cera alba, zinc stearate, jojoba seed oil, hexyllaurate, shea butter, cyclopentasiloxane, cyclohexasiloxane, A composition for strengthening nails, further comprising dimethicone, purified water, glycerin, disodium EDTA, allantoin and phenoxyethanol.
According to claim 1,
Including the retinol-based derivative, panthenol, biotin and dimethyl sulfone,
A composition for strengthening nails, further comprising purified water, glycerin, sucrose laurate, sucrose myristate, denatured alcohol, olive oil, sunflower seed oil, cacao seed butter, shea butter, grape seed oil, rosemary oil and lime peel oil .
According to claim 1,
Including the retinol-based derivative, panthenol, biotin and dimethyl sulfone,
Purified Water, Ethylhexylglycerin, Potassium Bate, Denatured Alcohol, Polyurethane-1, Polyurethane-34, Acrylates Copolymer, Tocopherol, Caprylyl Glycol, PEG-12 Dimethicone, Methylpropanediol and Phenylpropanol A composition for strengthening nails, characterized in that it further comprises.

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