KR102359520B1 - Cosmetic Composition Containing Mixture of Arginine, Hyaluronic Acid and Macadamia Nut Oil for Improving Moisturizing Effect of Hair - Google Patents

Abstract

The present invention is a cosmetic composition for improving the moisturizing power of hair comprising a mixture of arginine, hyaluronic acid and macadamia nut oil, and more particularly, arginine, hyaluronic acid and macadamia for increasing the moisture content of hair (especially damaged hair). It relates to a cosmetic composition for improving moisturizing power of hair comprising a mixture of nut oil as an active ingredient. The cosmetic composition for improving the moisturizing power of hair, preferably damaged hair, comprising a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient according to the present invention increases the amount of moisture in the hair and suppresses evaporation of moisture in the hair. It has the effect of improving the retention of moisture in the hair and increasing the retention period of moisture in the hair.

Description

Cosmetic Composition Containing Mixture of Arginine, Hyaluronic Acid and Macadamia Nut Oil for Improving Moisturizing Effect of Hair, comprising a mixture of arginine, hyaluronic acid and macadamia nut oil

The present invention is a cosmetic composition for improving the moisturizing power of hair comprising a mixture of arginine, hyaluronic acid and macadamia nut oil, and more particularly, arginine, hyaluronic acid and macadamia for increasing the moisture content of hair (especially damaged hair). It relates to a cosmetic composition for improving moisturizing power of hair comprising a mixture of nut oil as an active ingredient.

Although hair is not directly related to life, it has functions such as protection of the body, warmth and touch, and also acts as a cushion against friction generated from the outside, and protects the head from direct sunlight, cold and heat. do

In particular, eyebrows, eyelashes, nose hair, and ear hair among the hairs have a defense function against intrusion of sweat, dust and insects, and have a function of absorbing heavy metals such as mercury, arsenic, and lead unnecessary to the body and discharging them out of the body.

In addition, hair plays an important role in representing the characteristics of men and women in terms of decoration. Even the same person can give a different impression by changing the hairstyle and hair color. In this way, hair not only protects the head, but also plays a decorative role.

Hair is a thin and thin protein structure with an average thickness of about 0.07 mm, and can be broadly divided into a hair shaft that is outside the skin and a hair root that is inside the skin. The scalp has a basic structure and physiological function similar to that of the skin, and the hair follicle of the scalp is more complex than other areas and has many sebaceous glands. The hair root is the part inside the hair follicle, which is buried in the scalp, and the depth is about 2-4 mm. The bottom part of the hair root is swollen like a bead, and this part is called a hair bulb, and the thickness of the hair is determined by the size of this part.

If you enlarge the cross section of the hair, it is divided into three parts: the innermost part and the center, the medulla, the cortex surrounding the medulla, and the outermost part, the cuticle. The epidermis covers the surface of the hair and is a place with strong chemical resistance that surrounds the inside of the hair. The cortex is located inside the epidermis and occupies most of the hair (85-90%). Its main component is keratin protein, and it is composed of cortical cells and intercellular binding materials. . The medulla is present in the center of the hair and contains some melanin pigment particles.

Hair is damaged by friction, heat, physical cutting, perm, bleaching, dyeing, sunlight, etc. First, in the case of hair damage due to heat, the moisture evaporates and dries by the heat generated in the dryer during drying after washing the hair, causing the hair to expand and deform, and the black hair is discolored to dark brown. In addition, bubbles start to form in the cortex and medulla, the hair loses elasticity, and the epidermis melts.

Second, hair damage caused by perm is caused by poor treatment of perm solution, lack of time to leave, etc. If the hair becomes weak, alkali remains in the hair, or an oxidizer remains, it causes denaturation of keratin protein and fading of melanin pigment.

Third, as a bleaching agent, the oxidative bleaching action of the melanin pigment by hydrogen peroxide in addition to the alkali agent occurs. Repeated exposure to bleach in the short term causes repeated swelling and softening of the hair or twisting of the epidermis and causing damage.

Finally, the keratin protein of the hair is damaged or the protein is denatured by infrared rays and ultraviolet rays among sunlight.

As such, modern people damage their hair by perming, drying, and dyeing, and frequent washing has become unavoidable due to the use of various hair dressings and air pollution. However, despite many efforts to restore the damaged hair to its original healthy state due to frequent chemical treatment and washing, the results were small. This is because hair is a dead tissue unlike other living tissues, so there is a limit to revive the damaged area.

For example, hair conditioners have been mainly used to prevent and improve such hair damage. Hair conditioners mainly contain long-chain quaternary ammonium compounds, higher fatty alcohols, hydrocarbon oils, and silicone oils. In the above, the long-chain quaternary ammonium cationic surfactant, higher fatty alcohol, and hydrocarbon oil provide luster, moisture, and softness to the hair, and the silicone oil is artificially used to reduce the stiffness of the hair due to the removal of sebum after shampooing. It is used to give the hair softness and shine by giving it a feeling similar to sebum.

Moisturizing the hair is achieved by moisture inside the hair and moisture on the hair surface. The moisture inside the hair determines the flexibility of the hair, and the moisture on the surface of the hair determines the degree of moisture. However, since the moisture contained inside the hair is in equilibrium with the outside of the hair, it is greatly affected by the external environment, ie, temperature, humidity, ultraviolet rays, and the like. Therefore, if not only the initial moisture content but also the moisture contained in the hair is not effectively preserved, the hair becomes dry and brittle.

At room temperature and above pressure (25°C, 1 atmosphere), hair has an average moisture content of around 20%, and the moisture content varies from 3 to 34% depending on the relative humidity of the hair. Due to the structural specificity of the hair, which is composed of a lipid layer composed of lipids on the surface of the cuticle and a structure composed mainly of proteins called the cuticle, moisture in the hair exists in the hair in a form with two physical properties (C Barba, et. al. , Thermochimica Acta , 494:136-140, 2009). It is divided into external water and internal water. External moisture is the moisture mainly present on the surface of the hair due to non-covalent bonding that evaporates when heated at 65°C for 40 minutes, and internal moisture is at 180°C for 20 minutes. It is moisture that is stably present through ionic bonds with amino acids of hair constituent proteins that evaporate when heated.

To understand the characteristics of hair moisture, and to effectively and intrinsically moisturize hair that has been dried by bleaching procedures, styling, and environmental (UV, fine dust) damage, we have discovered materials that can take care of external and internal moisture, respectively. , There is an urgent need to develop a composition that improves the elasticity, softness, and calmness of hair by improving the moisturizing power of inner and outer moisture of the hair, and that removes the discomfort of dry hair from customers.

Most of the conventional moisturizing mechanisms use a material with high affinity for water, such as protein or protein derivative, inside the hair to retain moisture, and then apply a moisturizer, an emollient, and a humectant to the outside of the hair. ) was to be moisturized by treatment with a moisture evaporative agent, such as. However, although this method maintains the moisture of the hair to some extent, it is impossible to completely prevent the evaporation of moisture, so the moisture inside the hair is still in equilibrium with the external moisture. Therefore, there is a problem that it is difficult to effectively moisturize the hair because it is affected by external environments such as temperature, humidity, and ultraviolet rays.

Macadamia Nut Oil (Macadamia Ternifolia Seed Oil) is a vegetable oil extracted from macadamia fruits harvested in Australia, Hawaii, Brazil, South Africa, Israel, etc. and 80% or more of the total weight consists of monounsaturated fatty acids.

Oleic acid, the main component of macadamia nut oil, has skin anti-aging activity, and palmitoleic acid, which accounts for about 20% by weight of macadamia nut oil, is also found in animals, and animal skin It is an essential component of sebum.

Palmitoleic acid, which accounts for about 22% by weight of the lipid component contained in human skin, together with palmitic acid, accounts for about half of the skin lipid, and provides skin lubrication, softening, and protein structure. It has been reported to have functions such as protection of

In particular, palmitoleic acid is a carrier and emollient that has excellent spreadability and penetrability, and has excellent absorption, leaving a soft and non-sticky feeling when applied to the skin. Protects the skin from free radicals. Palmitoleic acid is a supplement of palmitoleic acid in the skin, which is reduced during skin aging, and can be used in cosmetic formulations such as creams. It can also be used for full body massage and is suitable for all skin types, especially for dry skin or skin with poor elasticity and moisture.

The cosmetic composition containing macadamia nut oil is not limited in formulation, but may contain various components that are formulated in a conventional cosmetic composition according to various formulations or suitable for the final purpose. As a cosmetic formulation example, an emollient containing macadamia nut oil in an amount of about 5 to 10% by weight can be used as an anti-aging supplement or a sunscreen, and macadamia nut oil is used in an amount of about 2 to 10% by weight. It can be used as a lipstick formulation containing It can be used as a carrier, and macadamia nut oil can also be used as a substitute for mineral oil or jojoba oil in creams or lotions.

Under this technical background, the present inventors have developed a cosmetic composition for improving hair moisture that allows hair to maintain high flexibility and moisture for a long time without being affected by external environments such as temperature, humidity or ultraviolet rays As a result of diligent efforts to develop , a cosmetic composition for improving hair moisture containing a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient increases the amount of moisture in the hair and suppresses the evaporation of moisture in the hair. It has been found that the effect of improving the retention of moisture and increasing the retention period of moisture in the hair can be obtained, and thus the present invention has been completed.

It is an object of the present invention to provide a cosmetic composition for improving moisturizing power of hair comprising a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient.

Another object of the present invention is to provide a cosmetic composition for improving the moisturizing power of damaged hair comprising a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient.

Another object of the present invention is to provide a cosmetic prepared from the cosmetic composition.

In order to achieve the above object, the present invention provides a cosmetic composition for improving the moisturizing power of hair comprising a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient, preferably a cosmetic composition for improving the moisturizing power of damaged hair.

Another object of the present invention is to provide a cosmetic prepared from the cosmetic composition.

The cosmetic composition for improving the moisturizing power of hair, preferably damaged hair, comprising a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient according to the present invention increases the amount of moisture in the hair and suppresses evaporation of moisture in the hair. It has the effect of improving the retention of moisture in the hair and increasing the retention period of moisture in the hair.

Figure 1 shows the change in the amount of moisture in the hair of damaged dry hair treated with arginine or hyaluronic acid (Graph: Mean ± standard error of measurement (SEM)).
Figure 2 shows changes in the amount of surface moisture in damaged dry hair treated with free fatty acids (Graph: Mean ± standard error of measurement (SEM)).
3 shows the change in the amount of surface moisture in damaged dry hair treated with macadamia nut oil (Graph: Mean ± standard error of measurement (SEM)).
Figure 4 shows the change in the amount of moisture in the hair of damaged dry hair treated with a mixture of arginine, hyaluronic acid and macadamia nut oil (Graph: Mean ± standard error of measurement (SEM)).
Figure 5 shows the change in the amount of moisture in the hair of damaged dry hair treated with one or more of arginine, hyaluronic acid and macadamia nut oil (Graph: Mean ± standard error of measurement (SEM)).
6 shows changes in the amount of surface moisture in damaged dry hair treated with one or more of arginine, hyaluronic acid, and macadamia nut oil (Graph: Mean±standard error of measurement (SEM)).

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In general, the nomenclature used herein is those well known and commonly used in the art.

The term "about" as used herein to express a concentration or weight means that there is a tolerance of up to 10% in the numerical value or numerical range.

In one embodiment of the present invention, in order to confirm the efficacy of increasing the amount of moisture in the hair of arginine or hyaluronic acid, arginine or hyaluronic acid was treated to damaged dry hair, and then the change in the amount of moisture in the hair was confirmed. As a result, as shown in FIG. 1 and Table 1, it was confirmed that arginine or hyaluronic acid has an effect of increasing the moisture content of hair at an appropriate effective content, respectively, and in particular, arginine is treated 100ppm or more, or hyaluronic acid is 1000ppm or more In the treated damaged dry hair, the amount of moisture in the hair was increased statistically significantly compared to the control group (untreated damaged dry hair) (see Test Example 1).

In another embodiment of the present invention, in order to confirm the effect of increasing the amount of surface moisture of free fatty acids, free fatty acids were treated on damaged dry hair, and then the change in the amount of surface moisture of the hair was confirmed. As a result, as shown in FIG. 2 and Table 2, it was confirmed that palmitoleic acid had the effect of remarkably increasing the amount of surface moisture in the hair at an appropriate effective content. The moisture content was increased (see Test Example 2).

In another embodiment of the present invention, macadamia nuts containing a high content of palmitoleic acid in vegetable oil (Palmitoleic acid, cis-9-hexadecenoic, 16:1 (n-7); molecular weight 254.4 Da; melting point 0.5° C.) In order to confirm the efficacy of the oil to increase the amount of surface moisture in the hair, macadamia nut oil was treated on damaged dry hair, and then, the change in the amount of surface moisture in the hair was checked. As a result, as shown in FIGS. 3 and 4, it was confirmed that macadamia nut oil had the effect of increasing the amount of surface moisture in the hair at an appropriate effective content. Compared to untreated, damaged dry hair), the amount of surface moisture in the hair was increased statistically significantly. On the other hand, as shown in Table 4, even when macadamia nut oil having a final concentration of 10ppm, 100ppm, 1,000ppm or 10,000ppm was treated to damaged dry hair, there was little change in the amount of moisture in the hair (see Test Example 3).

Among the vegetable oils containing a high content of palmitoleic acid, macadamia oil (19.3% by weight), avocado oil (7.5% by weight), olive oil (2.5% by weight), coconut oil (1.5% by weight), coral oil ( Jatropha) (1.5 wt%), almond oil (1.0 wt%). Jojoba oil (1.0% by weight) and the like (see Jang et al., J Plant Biotechnol , 37:25-46, 2010), such as avocado oil, olive oil, coconut oil, coral oil, almond oil. An oil high in palmitoleic acid, such as jojoba oil, can be applied to the present invention as a substitute for macadamia nut oil.

In another embodiment of the present invention, a mixture of arginine, hyaluronic acid, and macadamia nut oil is treated on damaged dry hair to confirm the efficacy of increasing the amount of moisture in the hair treated with a mixture of arginine, hyaluronic acid and macadamia nut oil. Then, the change in the amount of moisture in the hair was confirmed. As a result, as shown in FIGS. 4 and 5, it was confirmed that the mixture of arginine, hyaluronic acid, and macadamia nut oil had an effect of increasing the moisture content of the hair at an appropriate effective content. In particular, the mixture was arginine, hyaluronic acid And when using a mixture of 100 ppm of arginine, 1000 ppm of sodium hyaluronate, and 10 ppm of macadamia nut oil, rather than mixing macadamia nut oil at an equivalent ppm concentration, it was confirmed that the synergistic effect of increasing the moisture content of the hair in a statistically significant way was high. became In addition, as shown in FIGS. 5 and 6, the mixture of arginine, hyaluronic acid and macadamia nut oil has a synergistic effect of increasing the amount of moisture in the hair statistically significantly more than the mixture of arginine and hyaluronic acid (two types of mixture group). It was confirmed to be high (see Test Example 4).

In another embodiment of the present invention, at least one of arginine, hyaluronic acid, and macadamia nut oil is applied to damaged dry hair to confirm the efficacy of increasing the amount of surface moisture in the hair treated with arginine, hyaluronic acid, and macadamia nut oil. After treatment, the change in the amount of surface moisture in the hair was confirmed. As a result, as shown in FIG. 6 and Table 6, it was confirmed that the mixture of arginine, hyaluronic acid and macadamia nut oil had the effect of increasing the amount of surface moisture in the hair at an appropriate effective content. In particular, arginine, hyaluronic acid and macadamia nut oil The mixture of oil was found to have a higher synergistic effect of increasing the amount of surface moisture in the hair statistically significantly than the mixture of arginine and hyaluronic acid (two types of mixture group) (see Test Example 5).

Accordingly, in one aspect, the present invention relates to a cosmetic composition for improving the moisturizing power of hair comprising a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient, preferably a cosmetic composition for improving the moisturizing power of damaged hair.

The arginine (Arginine, Arg) has a transparent color at room temperature, exists in a liquid state, and is an amino acid added to fragrances, hair conditioning agents, skin conditioning agents, etc., in the cosmetic composition according to the present invention, about 10 to 10,000 ppm ( about 0.001 to 1 wt%), preferably about 100 to 1,000 ppm (about 0.01 to 0.1 wt%).

The hyaluronic acid (Hyaluronic Acid, Hyaluronan, HA) has a transparent color at room temperature, exists in a liquid state, and is a material added to scalp protectants and hair improvers, etc., in the cosmetic composition according to the present invention, about 100 to 100,000 ppm ( about 0.01 to 10% by weight), preferably about 1,000 to 10,000ppm (about 0.1 to 1% by weight).

The macadamia nut oil (Macadamia Nut Oil) has a transparent or yellow color at room temperature, exists in a liquid state, and is a substance known to contain a large amount of pallitoleic acid. In the cosmetic composition according to the present invention, about 1 to 1,000 ppm (about 0.0001 to 0.1 wt%), preferably, about 10 to 100 ppm (about 0.001 to 0.01 wt%).

The mixture comprising arginine, hyaluronic acid, and macadamia nut oil included in the cosmetic composition according to the present invention is a mixture of arginine, hyaluronic acid and macadamia nut oil in a ratio of 10:100:1 by weight. It may be characterized.

In the present invention, in consideration of the formulation stability of the cosmetic composition comprising a mixture of arginine, hyaluronic acid and macadamia nut oil and the limited amount of use in cosmetic methods, the amount of arginine in the mixture is 10, which is the mixed weight ratio of arginine, hyaluronic acid and macadamia nut oil : Based on the total weight of the composition in a state of maintaining 100:1, 0.09% by weight or less, preferably 0.01 to 0.09% by weight, more preferably 0.01 to 0.05% by weight, but pH is the upper limit of cosmetics pH9 It may be characterized in that it is included in the composition by neutralizing arginine (arginine stock solution) so as not to exceed .0. The amount of hyaluronic acid in the mixture is 0.9% by weight or less, preferably 0.1 to 0.9% by weight, based on the total weight of the composition while maintaining the 10:100:1 mixing weight ratio of arginine, hyaluronic acid and macadamia nut oil. , More preferably, it may be characterized in that it is included in the composition in an amount of 0.1 to 0.5% by weight. The amount of macadamia nut oil in the mixture may vary depending on the formulation of the composition. In the case of a wool formulation, the amount of macadamia nut oil is 0.009 based on the total weight of the composition while maintaining the 10:100:1 mixing weight ratio of arginine, hyaluronic acid and macadamia nut oil. Weight % or less, preferably 0.001 ~ 0.009% by weight, more preferably 0.001 ~ 0.005% by weight may be included in the composition.

In the present invention, if the content of the mixture is less than about 0.1% by weight (about 1,000ppm) based on the total weight of the cosmetic composition, the hair moisturizing effect is insignificant, and when it exceeds about 1.0% by weight (about 10,000ppm), the content increases Since the increase in the effect is not large compared to that, the mixture is 0.1 to 1.0% by weight (1,000 to 10,000ppm), preferably 0.1 to 0.5% by weight (1,000 to 5,000ppm), more preferably based on the total weight of the composition is 0.1 to 0.2% by weight (1,000 to 2,000ppm), most preferably 0.111% by weight (1,110ppm) is included.

In the present invention, the composition may be characterized in that it increases the external water content of hair, preferably damaged hair.

In the present invention, the composition may be characterized in that it increases the internal water content of the hair, preferably the damaged hair.

In the present invention, the damaged hair may be characterized in that it is caused by one or more chemical procedures selected from the group consisting of dyeing and perming, physical damage, stress, or nutritional deficiency.

The external moisture content of the hair accounts for about 75% of the moisture content of the hair, and may vary greatly depending on the relative humidity (RH), pH, temperature, etc. of the environment to which the hair is exposed.

The outer moisture of the hair is moisture lost by evaporation at a temperature of about 65° C. or higher, and is mainly present in the hair cuticle CMC (Cell Membrane Complex).

The moisture content of the hair accounts for about 25% of the moisture content of the hair, and there is little change in the moisture content within the range of 25 to 95% of the relative humidity (RH) of the environment to which the hair is exposed.

The moisture in the hair is moisture lost by evaporation at a temperature of about 180° C. or higher, and exists in a state of hydrogen bonding with amino acids in the interlamellar space of the hair.

In the present invention, the composition may be characterized in that it is for inhibiting moisture volatilization of damaged hair and improving moisturizing power.

In the present invention, the damaged hair may be caused by one or more chemical treatments selected from the group consisting of dyeing and perming, physical damage, stress, or nutritional deficiency, but is not limited thereto.

In the present invention, the cosmetic composition is not particularly limited in formulation, but ointment, nourishing lotion for hair, massage cream for hair, hair pack, hair tonic, hair lotion, hair rinse, hair treatment, scalp treatment, hair shampoo , may be a cosmetic composition having a formulation such as pomade. The cosmetic composition of each of these formulations may contain various components that are formulated in a conventional cosmetic composition according to the above-mentioned various formulations or suitable for the final purpose, and the types and amounts of these components can be easily selected by those skilled in the art.

In the present invention, the cosmetic composition may contain other ingredients commonly formulated in cosmetics. In this case, the ingredients include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, UV absorbers, preservatives, disinfectants, antioxidants, plant extracts, pH adjusters, alcohol, pigments, fragrances, blood circulation promoters , a cooling agent, a limiting agent, purified water, etc. may be used.

Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not to be construed as being limited by these examples.

test example 1: hair amount of water Evaluation of the efficacy of improving the moisturizing power of hair by arginine or hyaluronic acid according to the measurement

In order to confirm the efficacy of arginine or hyaluronic acid to increase the amount of moisture in the hair, arginine or hyaluronic acid was treated to damaged dry hair, and then, the change in the amount of moisture in the hair was confirmed by TG assay (Thermogravimetric assay).

<Test subject>

Normal hair : Standard hair, 10 cm long normal black hair (Tress, BM-B10, Beaulax, Japan).

Damaged dry hair : The normal hair was bleached for 30 minutes with a bleaching agent (a bleaching agent mixed with agent 1: 2 agent 3:1), then treated with shampoo (Amos Shampoo, Amore), and then treated with a shampoo (Amos shampoo, Amore) for 3 minutes at a temperature of 30°C Damaged dry hair prepared by washing with water and drying (drying for 10 minutes with the surface temperature of the hair below 50°C).

<Sample for hair treatment>

Sample for hair treatment 1: Using an arginine stock solution (prepared by dissolving arginine powder (manufactured by Sail) in water to a concentration of 10,000 mg/ml), the final concentration was 10ppm (0.001% by weight), 100ppm (0.01% by weight), Treated to the test subject hair to be 1,000ppm (0.1% by weight) and 10,000ppm (1% by weight). Here, the molar mass of arginine is 174.20 g/mol.

Sample 2 for hair treatment : Using hyaluronic acid stock solution (prepared by dissolving Sodium Hyaluronate Crosspolymer (manufactured by Sungwoon Bio) in water), the final concentration is 10ppm (0.001% by weight), 100ppm (0.01% by weight) , 1,000ppm (0.1% by weight) and 10,000ppm (1% by weight) were applied to the hair to be tested. Here, the chemical formula of hyaluronic acid is (C ₁₄ H ₂₁ NO ₁₁ ) _n , where n is in the range of 2 to 10,000, and the molar mass of hyaluronic acid is 400 to 4,000,000 g/mol.

Control : Treatment of test subject hair with water or alkyl benzoate at a dose of 100 μl.

<Hair treatment method>

Arginine (Sample 1 for hair treatment) or hyaluronic acid (Sample 2 for hair treatment) is applied (treated) to damaged dry hair (refer to <Test Subject>) at a concentration of 10 ppm, 100 ppm, 1,000 ppm or 10,000 ppm, followed by vinyl It was placed in a pouch to minimize exposure to external air (see Table 1 below for the treatment concentration of the sample for hair treatment for the test subject).

<Hair moisturizing power Measurement method: TG assay ( thermogravimetric assay)>

The moisture content of hair (untreated normal hair; untreated damaged dry hair; damaged dry hair treated with arginine or hyaluronic acid) was measured using a moisture meter (MS-70, A&D, Japan) (3 for each sample) measured in triplicate samples). At this time, the moisture content of the hair was measured by heating at 65℃ (program 5) and 180℃ (program 3) in two stages, and the moisture content of the hair was measured from 3 to 0.02% (w/w) by the sensor of the moisture meter. Cumulative water evaporation (% (w/w)) for 30 minutes was measured (C. Barba, et. al. , Thermochimica ). Acta , 494:136-140, 2009; Yash Kamath, et. al., J. Cosmet . Sci . , 65:37-48, 2014; See Clarence R. Robbins, Chemical and Physical Behavior of Human Hair , Chapter, 2.10 "Water: A Fundamental Component of Human Hair", 5th Edition, 2010).

Table 1 below shows the results of confirming the change in the amount of external and internal moisture of hair according to the treatment of arginine or hyaluronic acid by TG assay (Thermogravimetric assay).

As a result, as shown in FIG. 1 and Table 1, it was confirmed that arginine or hyaluronic acid has an effect of increasing the moisture content of hair at an appropriate effective content, respectively, and in particular, arginine is treated 100ppm or more, or hyaluronic acid is 1000ppm or more In the treated damaged dry hair, the amount of moisture in the hair was increased statistically significantly compared to the control group (untreated damaged dry hair).

test example 2: hair surface moisture of hair by free fatty acids according to the measurement moisturizing power Improvement Efficacy Assessment

In order to confirm the effect of increasing the amount of surface moisture by free fatty acids, different types of free fatty acids were treated to damaged dry hair, and then, the change in the amount of surface moisture was confirmed by TG assay (Thermogravimetric assay; see Test Example 1). (Control: Alkyl Benzoate (Saboderm ^™ )).

Table 2 below shows the results of confirming the changes in the amount of external and internal moisture of hair according to the treatment of free fatty acids by TG assay (Thermogravimetric assay).

As a result, as shown in FIG. 2 and Table 2, it was confirmed that palmitoleic acid had the effect of remarkably increasing the amount of surface moisture in the hair at an appropriate effective content. increased moisture content.

test example 3: hair surface moisture according to measurement Macadamia Efficacy evaluation of hair moisturizing power improvement by nut oil

To confirm the efficacy of macadamia nut oil, which contains a high content of palmitoleic acid among vegetable oils, to increase the surface moisture of the hair, macadamia nut oil was treated on damaged dry hair, and then the change in the surface moisture of the hair was analyzed by TG assay (Thermogravimetric). assay; see Test Example 1) (control group: Alkyl Benzoate (Saboderm ^TM )).

<Sample for hair treatment>

Sample for hair treatment 3 : Macadamia Nut Oil undiluted solution (Macadamia Seed Oil, Macadamia Integrifolia Seed Oil or Macadamia Ternifolia Seed Oil (ADM, BNH Tech) was mixed with Alkyl Benzoate (Manufactured by Alkyl Benzoate) Boderm ^TM ) to the final concentration of 10ppm (0.001% by weight), 100ppm (0.01% by weight), 1,000ppm (0.1% by weight) and 10,000ppm (1% by weight) using processed. The density of the stock solution of macadamia nut oil is 0.909-0.915 g/ml.

Here, the test subject, the control for hair treatment, the hair treatment method, and the hair moisturizing power measurement method are the same as in Test Example 1.

As the vegetable oil included in Sample 3 for hair treatment or a mixture of arginine, hyaluronic acid and vegetable oil to be described later, macadamia nut oil containing a high content of palmitoleic acid, a free fatty acid, was used.

The composition of free fatty acids contained in the macadamia nut oil stock solution (manufactured by BNH Tech) used in the present invention is shown in Table 3 below. The palmitoleic acid content of the stock solution is 15.0-22.0 wt%.

Fatty acid name Saturated/unsaturated fatty acids Content (% by weight) in macadamia nut oil Lauric Acid C12:0 <0.5 Myristic Acid C14:0 0.5~1.6 Palmitic Acid C16:0 7.0~9.5 Palmitoleic Acid C16:1 15.0~22.0 Stearic Acid C18:0 2.0~5.5 Oleic Acid C18:1 55.0~67.0 Linoleic Acid C18:2 1.0~5.0 Linolenic Acid C18:3 0.1~3.0 Arachidic Acid C20:0 1.5~3.0 Eicosenoic Acid C20:1 1.5~3.0 Behenic Acid C22:0 0.1~1.0

Table 4 below shows the results of confirming the changes in the amount of external and internal moisture of hair according to the treatment of macadamia nut oil by TG assay (Thermogravimetric assay).

As a result, as shown in FIGS. 3 and 4, it was confirmed that macadamia nut oil had the effect of increasing the amount of surface moisture in the hair at an appropriate effective content, and in particular, in damaged dry hair treated with macadamia nut oil 10ppm or more, the control group ( Compared to untreated, damaged dry hair), the amount of surface moisture in the hair was increased statistically significantly.

On the other hand, as shown in Table 4, even if the final concentration of 10ppm, 100ppm, 1,000ppm or 10,000ppm macadamia nut oil was treated on damaged dry hair, there was little change in the amount of moisture in the hair.

test example 4: hair amount of water Arginine, hyaluronic acid and macadamia Efficacy evaluation of hair moisture improvement effect by a mixture of ah nut oil

To confirm the efficacy of increasing the amount of moisture in the hair treated with one or more of arginine, hyaluronic acid, and macadamia nut oil, dry damaged hair was treated with one or more of arginine, hyaluronic acid, and macadamia nut oil, and then the amount of moisture in the hair The change of TG assay (Thermogravimetric assay; see Test Example 1) was confirmed. The concentrations of arginine, hyaluronic acid and macadamia nut oil were optimal concentrations confirmed in Test Examples 1 and 3.

Here, the test subject, the control for hair treatment, the hair treatment method and the hair moisturizing power measurement method are the same as in Test Example 1, and the mixture of arginine, hyaluronic acid and macadamia nut oil is an arginine stock solution and hyaluronic acid used for preparing a sample for hair treatment. Using the stock solution and the stock solution of macadamia nut oil (see Test Examples 1 and 3), the final mixing weight ratio of arginine, hyaluronic acid and macadamia nut oil is 1:1:1 (that is, '10ppm arginine + 10ppm hyaluronic acid + 10ppm macadamia nut oil) 'Sample; '100 ppm arginine + 100 ppm hyaluronic acid + 100 ppm macadamia nut oil' sample; '1,000 ppm arginine + 1,000 ppm hyaluronic acid + 1,000 ppm macadamia nut oil' sample), 10:10:1 (i.e., '100 ppm arginine + 100 ppm macadamia nut oil') hyaluronic acid + 10ppm macadamia nut oil' sample) and 10:100:1 (ie, '100ppm arginine + 1,000ppm hyaluronic acid + 10ppm macadamia nut oil' sample) by diluting in water, and then each mixture was After applying (treatment) to damaged dry hair (refer to <test subject>), it was placed in a plastic pouch to minimize exposure to external air (see Table 5 below for the treatment concentration of the hair treatment sample for the test subject).

Table 5 below shows the results of confirming the change in the amount of outer and inner moisture of hair treated with a mixture of arginine, hyaluronic acid and macadamia nut oil by TG assay (Thermogravimetric assay).

As a result, as shown in FIGS. 4 and 5, it was confirmed that the mixture of arginine, hyaluronic acid and macadamia nut oil had the effect of increasing the moisture content of the hair at an appropriate effective content. In particular, the mixture was arginine, hyaluronic acid And when using a mixture of 100 ppm of arginine, 1000 ppm of sodium hyaluronate, and 10 ppm of macadamia nut oil, rather than mixing macadamia nut oil at an equivalent ppm concentration, it was confirmed that the synergistic effect of increasing the moisture content of the hair in a statistically significant way was high. (compared to the untreated group with damaged dry hair ^* p<0.05, ^** p<0.01, ^*** p<0.001)

On the other hand, Table 6 below shows the results of confirming the change in the amount of outer and inner moisture of hair treated with one or more of arginine, hyaluronic acid, and macadamia nut oil by TG assay (Thermogravimetric assay).

As a result, as shown in FIGS. 5 and 6, the mixture of arginine, hyaluronic acid and macadamia nut oil has a synergistic effect that increases the amount of moisture in the hair statistically significantly more than the mixture of arginine and hyaluronic acid (two types of mixture group). was found to be high.

test example 5: hair surface moisture Arginine, hyaluronic acid and macadamia Efficacy evaluation of hair moisture improvement effect by a mixture of ah nut oil

In order to confirm the efficacy of increasing the surface moisture content of hair treated with one or more of arginine, hyaluronic acid, and macadamia nut oil, the damaged dry hair was treated with one or more of arginine, hyaluronic acid, and macadamia nut oil, and then the surface moisture content of the hair The change of TG assay (Thermogravimetric assay; see Test Example 1) was confirmed. The concentrations of arginine, hyaluronic acid and macadamia nut oil were optimal concentrations confirmed in Test Examples 1 and 3.

Here, the test subject, the control for hair treatment, the hair treatment method and the hair moisturizing power measurement method are the same as in Test Example 1, and the mixture of arginine and hyaluronic acid is an arginine stock solution and a hyaluronic acid stock solution (Test Example 1) to prepare by diluting in water so that the final mixing weight ratio of arginine and hyaluronic acid is 1:10 (ie, '100ppm arginine + 1,000ppm hyaluronic acid' sample), and arginine, hyaluronic acid and macadamia nut oil The mixture uses arginine stock solution, hyaluronic acid stock solution and macadamia nut oil stock solution (see Test Examples 1 and 3) used to prepare samples for hair treatment, and the final mixing weight ratio of arginine, hyaluronic acid and macadamia nut oil is 10:100:1 (i.e., '100ppm arginine + 1,000ppm hyaluronic acid + 10ppm macadamia nut oil' sample) was prepared by diluting in water, and then each mixture was applied (treated) to damaged dry hair (see <Test Subject>). Next, it was placed in a plastic pouch to minimize exposure to external air (see Table 6 for the treatment concentration of the sample for hair treatment for the test subject).

As a result, as shown in Figure 6 and Table 6, it was confirmed that the mixture of arginine, hyaluronic acid, and macadamia nut oil had an effect of increasing the amount of surface moisture in the hair at an appropriate effective content, in particular arginine, hyaluronic acid and macadamia nut The mixture of oil was found to have a higher synergistic effect in increasing the amount of surface moisture in the hair statistically significantly than the mixture of arginine and hyaluronic acid (two types of mixture group).

<Statistics processing>

Statistical analysis in Example 1 and Examples 3-5 was performed using the t-test test as a significance test between the two groups, and compared with the control group, ^* P <0.05, ^** P <0.01, ^*** P <0.001 cases were considered as valid differences.

Summarizing the results of Test Examples 1 to 5, when using a mixture of arginine, hyaluronic acid and macadamia nut oil than when using arginine, hyaluronic acid and macadamia nut oil alone or using a mixture of arginine and hyaluronic acid , it was confirmed that the moisture content of the hair was significantly increased, and the moisturizing power of the hair was remarkably improved.

Formulation example 1: ointment

An ointment containing a mixture of arginine, hyaluronic acid, and macadamia nut oil of the present invention was prepared by mixing the ingredients in Table 7 including the oil phase component and the aqueous phase component.

Ingredients content (wt%) Purified water remaining amount
Mixture containing arginine, hyaluronic acid and macadamia nut oil 10:100:1 by weight 0.99 caprin/caprylic triglyceride 10.00
liquid paraffin 10.00
Sorbitan Sesquioleate 6.00
Octyldodeces-25 9.00
Cetylethylhexanoate 10.00
squalane 1.00
salicylic acid 1.00
glycerin 15.00
sorbitol 10.00

Formulation example 2: Nutrient lotion for hair

By mixing the ingredients in Table 8 including the oil phase component and the water phase component, a nourishing lotion for hair containing a mixture of arginine, hyaluronic acid, and macadamia nut oil of the present invention was prepared.

Ingredients content (wt%) Purified water remaining amount Mixture containing arginine, hyaluronic acid and macadamia nut oil 10:100:1 by weight 0.09 beeswax 4.00 Polysorbate 60 1.50 Sorbitan sesquioleate 1.50 liquid paraffin 0.50 Montana 202 (Manufacturer: Seppic) 5.00 glycerin 3.00 butylene glycol 3.00 propylene glycol 3.00 Carboxyvinyl Polymer 0.10 triethanolamine 0.20 Preservatives, Colors, Flavors appropriate amount

Formulation example 3: Massage cream for hair

A massage cream for hair containing a mixture of arginine, hyaluronic acid, and macadamia nut oil of the present invention was prepared by mixing the ingredients in Table 9 including the oil phase component and the water phase component.

Ingredients content (wt%) Purified water remaining amount Mixture containing arginine, hyaluronic acid and macadamia nut oil 10:100:1 by weight 0.09 beeswax 10.00 Polysorbate 60 1.50 sebum 60 hydrogenated castor oil 2.00 Sorbitan sesquioleate 0.80 liquid paraffin 40.00 squalane 5.00 Montana 202 (Manufacturer: Seppic) 4.00 glycerin 5.00 butylene glycol 3.00 propylene glycol 3.00 triethanolamine 0.20 Preservatives, Colors, Flavors appropriate amount

Formulation example 4: hair pack

A pack containing a mixture of arginine, hyaluronic acid, and macadamia nut oil of the present invention was prepared by mixing the ingredients in Table 10 including the oil phase component and the aqueous phase component.

Ingredients content (wt%) Purified water remaining amount Mixture containing arginine, hyaluronic acid and macadamia nut oil 10:100:1 by weight 0.09 polyvinyl alcohol 13.00 Sodium Carboxymethyl Cellulose 0.20 glycerin 5.00 allantoin 0.10 ethanol 6.00 PINGG-12 Nonylphenyl Ether 0.30 Polysorbate 60 0.30 Preservatives, Colors, Flavors appropriate amount

Formulation example 5: hair tonic

A hair tonic including a mixture of arginine, hyaluronic acid, and macadamia nut oil of the present invention was prepared in a conventional manner according to the composition shown in Table 11.

Ingredients content (wt%) ethanol 50.00 menthol 0.02 glycerin 3.00 salicylic acid 0.05 Mixture containing arginine, hyaluronic acid and macadamia nut oil 10:100:1 by weight 0.99 Preservatives, Flavors and Colors appropriate amount Purified water remaining amount

Formulation example 6: hair lotion

A hair lotion comprising a mixture of arginine, hyaluronic acid, and macadamia nut oil of the present invention was prepared according to the composition shown in Table 12 in a conventional manner.

Ingredients content (wt%) cetostearyl alcohol 2.00 EDTA 2Na 0.20 hydroxyethyl cellulose 0.50 mineral oil 5.00 Mixture containing arginine, hyaluronic acid and macadamia nut oil 10:100:1 by weight 0.99 Preservatives, Flavors and Colors appropriate amount Purified water remaining amount

Formulation example 7: hair rinse and hair treatment

According to the composition shown in Table 13, a hair rinse and hair treatment containing a mixture of arginine, hyaluronic acid, and macadamia nut oil of the present invention were prepared in a conventional manner.

Ingredients content (wt%) propylene glycol 2.00 cetyltrimethylammonium chloride 1.00 cetyl alcohol 3.00 stearyl alcohol 3.00 mineral oil 0.50 citric acid 0.20 polydimethylsiloxane 1.00 Mixture containing arginine, hyaluronic acid and macadamia nut oil 10:100:1 by weight 0.99 Preservatives, Flavors and Colors appropriate amount Purified water remaining amount

Formulation example 8: hair shampoo

A hair shampoo containing a mixture of arginine, hyaluronic acid, and macadamia nut oil of the present invention was prepared by mixing the ingredients in Table 14 including the oil phase component and the aqueous phase component.

Ingredients content (wt%) Purified water remaining amount Mixture containing arginine, hyaluronic acid and macadamia nut oil 10:100:1 by weight 0.99 Ammonium Lauryl Sulfate (ALS) 20.0 Ammonium Laureth Sulfate (ALES) 20.0 cocamide mipa appropriate amount Disodium EDIT 0.03 Carbomer appropriate amount ethanol appropriate amount cocamide propyl betaine 6.00 Dimethicone (50%) 2.00 Dimethicone (70%) 2.00 DL-Panthenol appropriate amount tocopheryl acetate appropriate amount triethanolamine appropriate amount menthol appropriate amount Methylchloroisothiazolinone
Methylisothiazolinone Mixture (MC/IMI) 0.03 methylparaben appropriate amount Preservatives, Colors, Flavors appropriate amount

As described above in detail a specific part of the present invention, for those of ordinary skill in the art, it is clear that this specific description is only a preferred embodiment, and the scope of the present invention is not limited thereby. something to do. Accordingly, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

Claims (8)

A cosmetic composition for improving the moisturizing power of damaged hair for increasing the amount of moisture in the damaged hair, comprising a mixture of arginine, hyaluronic acid and macadamia nut oil as an active ingredient. According to claim 1, wherein the mixture is characterized in that arginine, hyaluronic acid and macadamia nut oil are mixed in a ratio of 10:100: 1 by weight. composition. According to claim 1, wherein the content of the mixture is 0.1 to 1.0% by weight based on the total weight of the composition, the cosmetic composition for improving the moisturizing power of damaged hair for improving the amount of moisture in the damaged hair. The method of claim 1, wherein the macadamia nut oil is lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, Characterized in containing free fatty acids consisting of Oleic Acid, Linoleic Acid, Linolenic Acid, Arachidic Acid, Eicosenoic Acid and Behenic Acid , A cosmetic composition for improving the moisturizing power of damaged hair for increasing the amount of moisture in the damaged hair. 5. The method of claim 4, wherein the macadamia nut oil contains less than 0.5% by weight of lauric acid, 0.5-1.6% by weight of myristic acid, 7.0-9.5% by weight of palmitic acid, and 15.0, based on the total weight of the macadamia nut oil. ~22.0 wt% palmitoleic acid, 2.0-5.5 wt% stearic acid, 55.0-67.0 wt% oleic acid, 1.0-5.0 wt% linoleic acid, 0.1-3.0 wt% linolenic acid, 1.5-3.0 wt% arachin A cosmetic composition for improving the moisturizing power of damaged hair for increasing the amount of moisture in damaged hair, characterized in that it contains free fatty acids consisting of acid, 1.5 to 3.0% by weight of eicosenoic acid, and 0.1 to 1.0% by weight of behenic acid. According to claim 1, wherein the mixture inhibits moisture volatilization of damaged hair and has an activity to improve the retention of moisture in the damaged hair, cosmetic composition for improving the moisturizing power of damaged hair for enhancing the amount of moisture in the damaged hair . According to claim 1, wherein the damaged hair is one or more chemical treatments selected from the group consisting of dyeing and perming, physical damage, stress or nutritional deficiencies, characterized in that the damaged hair is damaged for improving the amount of moisture A cosmetic composition for improving the moisturizing power of hair. The composition of claim 1, wherein the composition is selected from the group consisting of ointment, nourishing lotion for hair, massage cream for hair, hair pack, hair tonic, hair lotion, hair conditioner, hair treatment, scalp treatment, hair shampoo and pomade. A cosmetic composition for improving the moisturizing power of damaged hair for improving the amount of moisture in the damaged hair, characterized in that it is formulated.

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