KR102275550B1 - Composition for improving hair and scalp condition coprising extract of colored barley - Google Patents

Abstract

The present specification relates to a composition for improving hair and scalp conditions comprising a colored barley extract. More specifically, it relates to a composition for improving the condition of hair and scalp, which has an effect of alleviating itching and dandruff production of the scalp by including a colored barley extract, and exhibiting an effect of preventing hair loss and promoting hair growth. Therefore, the composition for improving hair and scalp conditions of the present specification may be used as a pharmaceutical, food or cosmetic composition.

Description

Composition for improving hair and scalp conditions comprising colored barley extract {COMPOSITION FOR IMPROVING HAIR AND SCALP CONDITION COPRISING EXTRACT OF COLORED BARLEY}

The present specification relates to a composition for improving hair and scalp conditions comprising a colored barley extract.

In the modern society that values beauty, hair dyes and perms are used to satisfy the desire to express individuality. In addition, various harmful substances from the outside continuously contaminate the scalp and hair. In the case of some sensitive scalps, chemical treatments such as dyeing and perming may cause irritation and inflammation such as itching or stinging of the scalp. These stimuli and inflammation lead to environmental hair loss, and various studies are being actively conducted to prevent hair loss that causes serious mental pain and promote hair growth.

Therefore, it is urgent to develop a composition having the effect of improving the scalp condition due to the use of various hair dyes, perming agents, and the like, external contaminants, as well as preventing hair loss and promoting hair growth.

Recently, in order to solve the above problems, a lot of compositions for external application for skin such as cosmetics using natural products have been developed. Accordingly, the present inventors have studied the possibility of application as external preparations for skin from plants that are not widely known so far.

US 10-0960054 B1

The inventors of the present specification solved the above problems and studied a composition that can suppress dandruff and improve scalp itchiness when used on hair and scalp, and at the same time provide a hair loss prevention and hair growth effect. As a result, when the colored barley extract is included , found that this problem can be solved and completed the present invention.

Accordingly, the problem to be solved by the present specification is to provide a composition capable of improving hair and scalp conditions.

In order to solve the above object, the present specification provides a composition for improving hair and scalp conditions comprising a colored barley extract as an active ingredient.

In one aspect of the present specification, the composition may be a composition for inhibiting dandruff or improving scalp itchiness and preventing hair loss and promoting hair growth.

According to the composition for improving hair and scalp conditions comprising the colored barley extract of the present specification, it is possible to provide an effect of improving scalp itchiness and preventing dandruff, preventing hair loss, and promoting hair growth, so compositions for external application for skin such as cosmetic compositions and pharmaceutical compositions can be used as

In one aspect, the present specification may relate to a composition comprising a colored barley extract as an active ingredient.

In one aspect of the present specification, the composition may be a pharmaceutical, food, or cosmetic composition.

In one aspect of the present specification, the composition may be a composition for improving hair or scalp condition.

In one aspect of the present specification, improvement of hair or scalp condition may include: alleviating scalp irritation; suppression of scalp itchiness; to improve, prevent or treat dandruff; to improve, prevent or treat hair loss; Or it may be one that promotes hair growth.

As used herein, colored barley is also called colored barley, functional barley or functional colored barley, and is an improved species of barley (Hordeum vulgare L.). Colored barley is rich in natural pigments, such as anthocyanins, and the color of colored barley may be black, purple, blue, yellow, purple, green, or red, but is not limited thereto.

In one aspect of the present invention, colored barley includes amethyst, jeomchal, ganghocheong and Jeju barley.

In the present specification, amethyst reconnaissance is a type of barley (Hordeum vulgare L.), which has been registered by applying for variety protection under the Seed Industry Act (variety protection application number: 2009-208, filing date: 2009.03.10, publication date: 2009.3.15, registration number: 4891, registration date: 2014.3.18). Amethyst reconnaissance is based on Tapgol barley (HB78100-B-17-3-2), which is strong in cold resistance and uniform, and is strong in disaster resistance and multiplicity. It is nurtured by performing artificial crossbreeding with the haga as a parent. The color of the leaves of Amethyst is green, the width is average, and the length is on the short side. The color of the net is purple and the length is short. The length of the mandrel is single mesh, and there are small thorns on the edge of the mandrel. The length of the liver is about 75 cm, and the length of the intestine is about 5.4 cm. The growth habit is semi-upright and the lower leaf sheath is hairless. The composition of the ears is six rows, the shape of the ears is rod-shaped, and the number density of the ears is close to the middle type. 1 The number of seeds is 63, which is a multi-grain type, and the one-thousand-grain weight is 27.2g, which is small and medium-sized. Purple Scout contains anthocyanins of 60.0 to 180.0 ug/g, has a higher beta-glucan content than general barley, has a lower lip whiteness of 31.6, and has excellent cooking properties with 403% spreadability. In the present specification, amethyst was commercially obtained from amethyst barley rice sold by Cheongmaek Co., Ltd., an agricultural company.

In the present specification, the gemstone , a kind of barley ( Hordeum vulgare L. ), has been registered by applying for variety protection according to the Seed Industry Act (variety protection application number: 2009-286, filing date: 2009.05.22, publication date: 2009.6.15, registration number: 4892, registration date: 2014.3.18). Jemjekmal is bred by artificial crossbreeding of glutinous rice barley and Haman Gukbuk glutinous rice barley, which have strong uniformity and cold resistance, high lip whiteness and venous rate due to their chewiness, and excellent cooking characteristics. The growth habit of Jemjeumchal is semi-upright, the lower leaf sheath has hairs, and the branch leaves are horizontal. Jeom's tag contains 180ug/g of anthocyanins. Leaf anthocyanin color is very light and there is no or very little white powder of leaf sheath. The color of the anthocyanin at the tip of the rump is medium, the ear white powder is medium, and the male part is erect. The soy sauce of the plant is long, the composition of the ears is six lines, the shape of the ears is rod-shaped, and the number density is medium. The length of the mango is long mesh, the length of the first segment of contraction is short, and the degree of bending of the first segment of ear neck is weak. In addition, the color of anthocyanins in the conduit part of the outer shell of the seed is dark. The length of hoyeong and hoyeongmang in preparation for the central few species and the hair of the author of the cultivar are long. In the present specification, Jeomchal received seeds from the Rice and Grains Department of the National Academy of Food Science, Rural Development Administration.

In the present specification, Kanghocheong is a type of barley (Hordeum vulgare L.), which has been registered by applying for variety protection under the Seed Industry Act (variety protection application number: 2009-398, filing date: 2012.06.22, publication date: August 15, 2012, publication number: 2012-430). The growth habit of Kangho-cheong is semi-upright, there is no leaf anthocyanin color, and there is almost no white powder on the leaf sheath. The color of the anthocyanin at the tip of the tip is very light, the level of ear white powder is medium, and the hand part is semi-upright. The soy sauce of Kang Ho-cheong is medium-long, the composition of the ears is six rows, and the shape of the ears is rod-shaped and the number density is medium. The length of the mandrel is single mesh, the length of the first constriction node is medium, and the degree of bending of the first node of the ear neck is medium. In addition, the anthocyanin color of the conduit part in the seed pods is medium. In the present invention, Ho-Cheong Kang received seeds from the Rice and Grain Department of the National Institute of Food Science and Technology.

In the present specification, Jeju barley, a kind of barley (Hordeum vulgare L.), has been registered by applying for variety protection under the Seed Industry Act (variety protection application number: 1998-178, filing date: 1998.12.04, application publication number) ; 2000-136, date of publication of application: February 15, 2000). Jeju barley artificially crossed Boanjin-Haganemugi and Samheung-Yunan in order to foster new varieties of high-quality innerwear, and selected SB77460-B-180, an intermediate mother with strong wear resistance. 82552-BK-19J-4-0 was selected after breeding a line by crossing it with a cultivar, and in 1988, it was disclosed in the main test for productivity test and the productivity and main characteristics were tested. As a result, the line name was given to Suwon No. 264 and '89/'92 It is a variety designated as a encouraged variety in 1993 after conducting a regional adaptation test. Its main morphological characteristics are that it is a two-stranded barley, and the ears are vertex, and the number density is very sparse. The growth habit of the plant is medium type, and there is no hair on the leaf sheath of the lower leaf, and the anthocyanin concentration in the branch leaf is high, and there is anthocyanin at the tip of the leaf, but the concentration is very light. The exudate belongs to the late succulent species, the soy sauce is medium, and the tip of the degenerated water is round. The length of the hair of the author of Jongsil is rather long, and the shape of the bast of the seed is opposite to each other, and the parity is I. In the present invention, Jeju barley received seeds from the Rice and Grain Department of the National Institute of Food Science and Technology.

In one aspect of the present specification, colored barley may be one or more selected from the group consisting of colored barley karak, inneryeong, outeryeong, and younggwa.

In one aspect of the present specification, the colored barley extract may be extracted by mixing young and inner young and outer young in a weight ratio of 1 to 10:1 to 3:1. The weight ratio may be 6-8: 1.5-2.5: 1, or 7:2:1.

In one aspect of the present specification, the colored barley extract may be one or more extracts selected from the group consisting of water, an organic solvent, and a mixture thereof. The organic solvent may be at least one selected from the group consisting of ethanol, butylene glycol, and propylene glycol.

In one aspect of the present specification, the composition may be a composition for external application to the skin.

The method for producing the colored barley extract used herein is not particularly limited, and in the present specification, for example, the colored barley extract is a leachate obtained by leaching and discharging from colored barley, and a concentrate obtained by concentrating some or all of the leaching solution again. , It includes an extract prepared by drying the concentrate again, or an oil obtained by distillation or containing a chemical substance that exerts the main effect contained in the extract.

As used herein, colored barley may be included in the form of an extract, a pulverized product of the crude drug itself, or a dry pulverized product of the crude drug, but is not limited thereto. In addition, the colored barley used in the present specification is not limited in the method of obtaining it, and it can be cultivated and used or can be purchased and used commercially, and one selected from the group consisting of colored barley, Naeyeong, Oeyeong, and Younggwa (穎果). The above may be used, and Younggwa may be preferably used.

In the present specification, "extract" includes all substances obtained by extracting the components of natural products, regardless of the extraction method, extraction solvent, extracted components, or the form of the extract, and also extracts the substances obtained by extracting the components of natural products after extracting other substances. It is a broad concept that includes all substances obtainable by processing or processing by a method.

As used herein, the term "coloured barley extract" includes all substances obtained by extracting the components of colored barley, regardless of the extraction method, extraction solvent, extracted component, or the form of the extract, and in the process of extracting the component, heat, acid (acid), base (base), including a material obtained through an extraction method including a process of enzyme treatment, etc., and can be obtained by extracting the material obtained by extracting the components of colored barley and processing or treating it by another method. It is a broad concept that includes all substances that exist.

In one aspect of the present specification, the colored barley extract comprises the steps of washing and drying colored barley; Solvent extraction of at least one selected from the group consisting of dry amethyst, jeomchal, ganghocheong and Jeju barley; And it can be obtained through the step of filtering the extracted colored barley. In the above, the solvent includes at least one selected from the group consisting of water, an organic solvent, and a mixture of water and an organic solvent. In the above, water includes distilled water or purified water, and the organic solvent is selected from the group consisting of alcohol, acetone, ether, ethyl acetate, diethyl ether, ethyl methyl ketone, and chloroform, for example, _{C 1} to C _{5 lower alcohol.} One or more include, but are not limited to.

The colored barley extract may include a C ₁ to C ₆ alcohol extract of colored barley, and specifically, the alcohol may be methanol or ethanol.

In the present specification, the colored barley extract may be a crude extract of a solvent selected from the group consisting _{of water, C 1} -C _{6 alcohol, and a combination thereof.} The C ₁ -C ₆ alcohol may be specifically methanol. When extracting colored barley with a solvent, it is preferable to extract by adding a solvent corresponding to about 5 to 15 times that of colored barley, and specifically, it is preferable to extract by adding a solvent of about 10 times, but is not limited thereto. Heat extraction, cold extraction, reflux cooling extraction, ultrasonic extraction, etc. may be used for the extraction, and there is no limitation as long as the extraction method is obvious to those skilled in the art. The extraction may be performed at room temperature, but for more efficient extraction, it may be performed under a heating condition, preferably at a temperature of about 40 to 100°C, more preferably at a temperature of about 80°C, but limited thereto it is not The extraction time is preferably about 2 to 4 hours, more preferably about 3 hours, but is not limited thereto, and may vary depending on conditions such as extraction solvent and extraction temperature. The extraction may be performed one or more times in order to obtain a larger amount of the active ingredient, preferably 1 to 5 times, more preferably 3 times consecutive extraction, and the combined extract may be used.

In the present specification, the colored barley extract may include the crude colored barley extract as described above, or it may be included as a soluble fraction of the organic solvent obtained by further extracting the crude extract with an organic solvent having low polarity. The organic solvent may be hexane, methylene chloride, ethyl acetate, n-butanol, or the like, but is not limited thereto. The extract extracted by the above method or a soluble fraction of the extract may be used as it is, but it may be used in the form of an extract by concentration after filtration, or in the form of a freeze-dried product after concentration and freeze-drying.

As used herein, the term “hair” refers to body hair and hair, and may also be described as hair. The hair includes both human and animal hair.

The colored barley extract of the present specification comprises the steps of mincing and drying colored barley; Adding water, an organic solvent, or a combination thereof to the dried colored barley and reflux extraction; filtration with a filter cloth after depositing the extract; centrifuging the filtrate to separate the residue and the filtrate; It can be obtained by a method comprising; concentrating the separated filtrate under reduced pressure to obtain a colored barley extract.

In one aspect of the present specification, the colored barley extract is composed of purified water, ethanol, butylene glycol, and propylene glycol so that the colored barley concentrate concentrated under reduced pressure according to the above method is included in 5% by weight based on the total weight of the extract. It may be prepared by dispersing/dissolving using one or more solvents selected from the group.

In addition, in the extraction process of the colored barley extract of the present specification, for example, water or an organic solvent is added to chopped and dried colored barley, extracted under reflux and deposited, and then the residue and the filtrate are separated through filter cloth filtration and centrifugation, The separated filtrate can be concentrated under reduced pressure to obtain a colored barley extract. The organic solvent usable herein may be selected from ethanol, methanol, butanol, ether, ethyl acetate, chloroform, or a mixed solvent of these organic solvents and water, and preferably 100% water, 70% ethanol in consideration of the safety of the raw material. Or butylene glycol (Butylene Glycol) is used. At this time, the extraction temperature is preferably 18 ~ 80 ℃ in the case of water, 18 ~ 40 ℃ in the case of 70% ethanol and butylene glycol, and the extraction time is preferably 6 ~ 168 hours. If the extraction temperature and extraction time are out of the range, extraction efficiency may decrease or a change in components may occur. After obtaining the extract using the solvent in the above, it is possible to obtain a liquid product by cooling, heating, and filtration at room temperature by a conventional method known in the art, or additionally evaporating the solvent, spray drying or freeze drying. In addition, during freeze-drying, freeze-drying may be performed at -50 to -70°C for 3 to 4 days.

In the present specification, the colored barley extract may be included in an amount of 0.00005 to 50% by weight based on the total weight of the composition. More preferably, 0.1 to 1% by weight or 0.5 to 10% by weight may be used. If the colored barley extract is less than 0.00005% by weight, the effect is insignificant, and if it is more than 50% by weight, stability or formulation problems may occur. Specifically, the colored barley extract is 0.0001 wt% or more, 0.0005 wt% or more, 0.001 wt% or more, 0.01 wt% or more, 0.1 wt% or more, 0.3 wt% or more, 0.5 wt% or more, 0.8 wt% or more, based on the total weight of the composition. , 1 wt% or more, 3 wt% or more, 5 wt% or more, 7 wt% or more, 10 wt% or more, 15 wt% or more, 20 wt% or more, 25 wt% or more, 30 wt% or more, 35 wt% or more , or 40% by weight or more, and may be 60% by weight or less or 50% by weight or less.

In one aspect of the present specification, the concentration of the colored barley extract may be 0.01ug/mL to 100ug/mL. In addition, the concentration of the colored barley extract is 0.01ug/mL or more, 0.1ug/mL or more, 0.3ug/mL or more, 0.4ug/mL or more, 0.5ug/mL or more, 0.6ug/mL or more, 0.7ug/mL or more, 1ug It may be /mL or more, 5ug/mL or more, 10ug/mL or more, 100ug/mL or more, or 1000ug/mL or more, and may be 100mg/mL or less or 10mg/mL or less.

The pharmaceutical composition according to the present specification may be in various oral or parenteral formulations. In the case of formulation, it is prepared using diluents or excipients, such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants. Solid preparations for oral administration include tablets, pills, powders, granules, soft or hard capsules, etc., and these solid preparations include at least one excipient in one or more compounds, for example, starch, calcium carbonate, sucrose. Or it is prepared by mixing lactose, gelatin, etc. In addition to simple excipients, lubricants such as magnesium stearate and talc are also used. Liquid preparations for oral administration include suspensions, internal solutions, emulsions, syrups, etc. In addition to commonly used simple diluents such as water and liquid paraffin, various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included. have. Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Non-aqueous solvents and suspensions may include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate. As the base of the suppository, witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, etc. can be used.

The pharmaceutical dosage form of the composition of the present specification may be used in the form of a pharmaceutically acceptable salt thereof, and may be used alone or in combination with other pharmaceutically active compounds as well as in an appropriate group. The salt is not particularly limited as long as it is pharmaceutically acceptable, and for example, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrofluoric acid, hydrobromic acid, formic acid acetic acid, tartaric acid, lactic acid, citric acid, fumaric acid, maleic acid, succinic acid, methanesulfonic acid , benzenesulfonic acid, toluenesulfonic acid, naphthalenesulfonic acid, and the like can be used.

The composition of the present specification may be administered parenterally or orally as desired, and may be administered in 1 to several divided doses to be administered in an amount of 0.1 to 500 mg, preferably 1 to 100 mg per 1 kg of body weight per day. have. The dosage for a specific patient may vary depending on the patient's weight, age, sex, health status, diet, administration time, administration method, excretion rate, severity of disease, and the like.

The pharmaceutical composition according to the present specification may be prepared according to a conventional method according to a conventional method; oral dosage forms such as powders, granules, tablets, soft or hard capsules, suspensions, emulsions, syrups, aerosols, external preparations for skin such as ointments, creams, suppositories, and injections And it may be formulated and used in any form suitable for pharmaceutical preparations, including sterile injection solutions.

The composition according to the present specification may be administered to mammals such as rats, mice, livestock, and humans by various routes such as parenteral and oral administration, and all modes of administration can be expected, for example, oral, rectal Or it may be administered by intravenous, intramuscular, subcutaneous, intrauterine dural or intracerebroventricular injection.

In one aspect of the present specification, the food composition may be a health functional food composition.

The formulation of the food composition according to the present specification is not particularly limited, but may be formulated as, for example, tablets, granules, powders, liquids such as drinks, caramel, gels, bars, and the like. In addition to the active ingredient, the food composition of each dosage form can be appropriately selected by those skilled in the art without difficulty depending on the dosage form or purpose of use in addition to the active ingredient, and a synergistic effect may occur when applied simultaneously with other raw materials.

In the food composition according to the present specification, the determination of the dosage of the active ingredient is within the level of those skilled in the art, and the daily dosage thereof is, for example, 0.1 mg/kg/day to 5000 mg/kg/day, more specifically 50 It may be mg/kg/day to 500 mg/kg/day, but is not limited thereto, and may vary depending on various factors such as age, health status, and complications of the subject to be administered.

The food composition according to the present specification is, for example, various foods such as chewing gum, caramel products, candies, ice creams, and confectionery, beverage products such as soft drinks, mineral water, alcoholic beverages, vitamins and minerals, etc. Health functional foods can

In addition to the above, the food composition of one aspect of the present specification includes various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic flavoring agents and natural flavoring agents, coloring agents and enhancers (cheese, chocolate, etc.), pectic acid and salts thereof, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. In addition, the functional food compositions of the present specification may include natural fruit juice and pulp for the production of fruit juice beverages and vegetable beverages. These components may be used independently or in combination. The proportion of these additives is not so important, but is generally included in the range of 0 to about 20 parts by weight per 100 parts by weight of the composition herein.

In one aspect of the present specification, the composition is not particularly limited in formulation, but a cosmetic composition having a formulation such as hair tonic, hair nourishing lotion, scalp treatment, hair treatment, hair rinse, hair shampoo, hair lotion, etc. can be

In addition, in each formulation, other components other than the above essential components can be suitably selected and formulated by those skilled in the art without difficulty depending on the type or purpose of use of other external preparations.

The cosmetic composition according to the present specification may be provided in any formulation suitable for topical application. For example, it may be provided in the form of a solution, an emulsion obtained by dispersing an oil phase in an aqueous phase, an emulsion obtained by dispersing an aqueous phase in an oil phase, a suspension, a solid, a gel, a powder, a paste, a microneedle, a foam, or an aerosol composition. have. Compositions of such formulations can be prepared according to conventional methods in the art.

The cosmetic composition according to the present specification may further include functional additives and components included in general cosmetic compositions in addition to the colored barley extract. The functional additive may include a component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, high-molecular peptides, high-molecular polysaccharides, sphingolipids, and seaweed extract.

The cosmetic composition according to the present specification may include other ingredients that can give a synergistic effect to the main effect, preferably within a range that does not impair the main effect, in addition to the colored barley extract. In addition, the cosmetic composition according to the present specification may further include a moisturizer, an emollient, a surfactant, a UV absorber, a preservative, a bactericide, an antioxidant, a pH adjuster, an organic and inorganic pigment, a fragrance, a cooling agent or a limiting agent. The blending amount of the component can be easily selected by those skilled in the art within the range that does not impair the purpose and effect of the present specification, and the blending amount may be 0.01 to 5 wt%, specifically 0.01 to 3 wt%, based on the total weight of the composition have.

Hereinafter, the present specification will be described in detail with reference to Examples, Comparative Examples and Test Examples of the present specification. These are merely presented by way of example in order to describe the present specification in more detail, and the scope of the present specification is not limited by these Examples, Comparative Examples and Test Examples.

[Preparation Example 1] Preparation of amethyst extract

In a weight ratio of 7:2:1, a total of 1 kg of amethyst reconnaissance spirit, outer young, and inner young were chopped and refluxed 3 times for 24 hours with 70% ethanol aqueous solution, cooled and cooled, and then extracted with Whatman #5 filter paper. filtered. The filtered extract was concentrated under reduced pressure at 45°C or lower and freeze-dried at -60°C for 3 days.

Amethyst extract was prepared by dispersing/dissolving using ethanol so that the reduced pressure concentrate was included in 5% by weight based on the total weight of the amethyst extract.

[Preparation Example 2] Preparation of Jemjeumchal Extract

A Jemchal extract was prepared in the same manner as in Preparation Example 1.

[Preparation Example 3] Preparation of Ganghocheong extract

Ganghocheong extract was prepared in the same manner as in Preparation Example 1.

[Preparation Example 4] Preparation of Jeju barley extract

Jeju barley extract was prepared in the same manner as in Preparation Example 1.

[Examples 1 to 4, Comparative Example 1]

Shampoos were prepared with the composition shown in Table 1 below. Specifically, a surfactant and ethylene glycol distearate are added to purified water and heated to 80° C. to be uniformly dissolved, then slowly cooled to 40° C. under stirring, and added to the mixture according to the present specification. It was prepared by adding and mixing active ingredients such as charcoal, ganghocheong, and Jeju barley extract with preservatives, viscosity modifiers, fragrances, and hair conditioning agents, and then cooling them to room temperature under stirring.

As a comparative example, Comparative Example 1 was prepared so as not to contain amethyst, gemstone, ganghocheong, or Jeju barley extract in Preparation Examples 1 to 4 (Example 1 (Amethyst), Example 2 (Jewel), Example 3 (Kanghocheong), Example 4 (Jeju barley)).

ingredient Examples 1 to 4 (wt%) Comparative Example 1 (wt%) Ammonium Lauryl Sulfate 10 8.0 Ammonium polyoxyethylene lauryl sulfate 5 5 Cocoamidopropyl Betaine 2 2 Ethylene glycol distearate 1.5 1.5 Cocoyl Monoethanolamide 0.8 0.8 Polyquaternium-10 0.2 0.2 Blue No. 1 0.0002 0.0002 Yellow No. 4 0.0001 0.0001 methylparaben 0.1 0.1 Spices 0.8 0.8 citric acid 0.1 0.1 dimethicone 1.0 1.0 The extract of any one of Preparation Examples 1 to 3 5.0 - Purified water To 100 To 100

[Test Example 1] Dandruff reduction effect test

Forty-eight males aged 19-35 with relatively high dandruff were selected and the shampoos of Examples 1 to 4 and Comparative Example 1 were used in 4 groups of 12 persons each for 1 month in the following manner, and then the dandruff reduction rate was measured .

Wash hair with a normal shampoo before the start of the test, collect the dandruff accumulated for 2 days after washing, and wash the hair once every 2 days with the weight of the collected dandruff and the shampoos of Examples 1 to 4 and Comparative Example 1 for 2 days after the end of the test The weight of accumulated dandruff was comparatively evaluated. In this case, the accumulated dandruff was collected directly from the scalp using a vacuum suction device, the dandruff reduction rate was calculated based on Equation 1 below, and the results are shown in Table 2 below.

[Equation 1]

Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Subject 1 12 11 12 11 1.6 subject 2 18.9 18.2 19.0 18.3 -0.5 subject 3 10.5 10.3 10.7 10.1 -0.9 Subject 4 7.8 7.7 7.7 7.5 1.8 Subject 5 15 14.5 14.5 15.1 2.5 Subject 6 5.1 5.1 5.3 5.5 1.1 subject 7 9 9 9.2 9.5 5.9 subject 8 8.9 8.5 8.8 8.9 3.2 Subject 9 13.8 13.5 13.6 13.7 3.4 Subject 10 15.4 14.9 15.1 14.9 4.8 Subject 11 9.2 9.0 9.1 9.2 3.2 Subject 12 8.5 8.2 8.5 8.6 3.9 medium 11.175 10.825 11.125 11.025 2.5 Standard Deviation 3.924776 3.735122 3.838116 3.711927948 2.009522784

As can be seen from Table 2 above, in the case of Examples 1 to 4, compared to Comparative Example 1, the width of the decrease in the amount of dandruff of the subjects increased by about 2 times on average. Therefore, it can be seen that Examples 1 to 4 exhibit a superior anti-dandruff effect than the case of not including amethyst, jemjeom, ganghocheong or Jeju barley extract.

[Test Example 2] Scalp itch prevention effect test

Forty-eight men and women aged 25 to 45 years who feel relatively itchy scalp were selected and divided into 4 groups of 12 people each. After using the shampoos of Examples 1 to 4 and Comparative Example 1 once every 3 days for 2 weeks, the scalp The anti-itch effect was evaluated through the following evaluation criteria, and the results are shown in Table 3 below.

[Evaluation standard]

Very good - 5 points

Excellent - 4 points

Moderate - 3 points

Bad - 2 points

Very poor - 1 point

Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Evaluation results 4.0 4.2 4.1 4.2 2.1

As can be seen from Table 3 above, the case of Examples 1 to 4 showed a superior effect of preventing scalp itchiness compared to Comparative Example 1 (not including amethyst, jeomchal, ganghocheong, or Jeju barley extract). can be seen to indicate

[Test Example 3] Hair follicle dermal papilla cell proliferation effect test

Keratin protein constituting hair is produced in keratinocytes at the root of the hair, and these keratinocytes are differentiated from dermal papilla cells. In order to evaluate the activity of the dermal papilla cells of the composition according to the present specification, in the present specification, human primary dermal papilla cells isolated from human tissues were used. After isolation of primary dermal papilla cells from human tissue, 5% CO2, 37 in DMEM (Dulbecco's modified Eagle's medium; Gibco BRL, Gaithersburg, MD, USA) containing 10% fetal bovine serum (FBS). It was cultured for 24 hours in an incubator maintained at °C.

The cultured human primary dermal dermal papilla cells were treated with the extracts of Preparation Examples 1 to 3 as shown in Table 4, and cultured in a 96-well plate at 37° C. in an incubator for 24 hours. Comparative Example 2 is an untreated group that is not treated with the extract. After 24 hours of drug treatment, cell proliferation was measured using a WST-1 kit (Roche), and the results are shown in Table 5.

Preparation Example 1 Preparation 2 Preparation 3 Preparation 4 Comparative Example 2 Concentration: ppm 5 5 5 5 -

Preparation Example 1 Preparation 2 Preparation 3 Preparation 4 Comparative Example 2 cell growth rate
(%) 123±1.8 120±2.1 121±2.1 122±2.0 100±1.8

From the results of Table 5, it can be confirmed that the dermal papilla cell proliferation effect of Examples 1 to 4 treated with amethyst, jeomchal, ganghocheong or Jeju barley extract. Therefore, it was confirmed that the composition comprising amethyst, Jemchal, Ganghocheong or Jeju barley extract according to the present specification can exhibit the effect of promoting hair growth by promoting the proliferation of dermal papilla cells of hair follicles when treated on the scalp.

[Test Example 4] Hair loss prevention effect test

In order to confirm whether the present invention is effective in preventing hair loss of scalp hair, the effect of preventing hair loss was tested clinically. As a test method, only patients who satisfy all of the following criteria were enrolled as study subjects.

1) A person who is over 20 years of age and has good physical and mental health and is experiencing hair loss

2) Patients who will maintain the same hairstyle for the duration of the study

3) Patients who will not be stained during the study period

4) Patients who will not use special hair products or hair care and manipulation during the study period

Twenty voluntary subjects who met the above conditions were carefully selected and tested, and the specific status of each individual patient was identified and recorded on the evaluation sheet and tested.

For the method of evaluating the effect of preventing hair loss, the number of hairs falling out when washing the hair was measured. Before using the shampoo corresponding to Examples 1 to 4 and Comparative Example 1 and 3 months after using the shampoo were compared. The number of hairs falling out when washing the hair was recorded once a day, and the amount of hair loss was averaged in units of one month.

division Comparative Example 2 Example 1 Example 2 Example 3 Example 4 After 1 month of use 17.61 11.73 11.50 11.22 11.52 After 2 months of use 14.12 10.84 10.72 10.51 10.91 After 3 months of use 12.11 5.98 5.82 5.80 6.10

As described above, it was found that the amount of hair loss significantly decreased by more than half as the number of months after using the shampoos corresponding to Examples 1 to 4 passed. From the above test results, it was confirmed that the present specification provides a composition that is safe to the living body and provides hair loss prevention and hair growth effects by using amethyst reconnaissance, jeomchal, ganghocheong or Jeju barley extract.

Formulation examples of the composition according to one aspect of the present specification are described below, but other various formulations are also applicable, which is not intended to limit the present specification, but only to be specifically described.

[Formulation Example 1] Soft capsule

8 mg of any one of the extracts of Preparation Examples 1 to 4, 9 mg of vitamin E, 9 mg of vitamin C, 2 mg of palm oil, 8 mg of hydrogenated vegetable oil, 4 mg of yellow wax and 9 mg of lecithin are mixed, and mixed according to a conventional method to prepare a soft capsule filling solution . Soft capsules are prepared by filling 400 mg per capsule. And, separately from the above, a soft capsule sheet was prepared in a ratio of 66 parts by weight of gelatin, 24 parts by weight of glycerin, and 10 parts by weight of sorbitol solution, and the filling solution was filled to prepare a soft capsule containing 400 mg of the composition according to the present specification.

[Formulation Example 2] Tablet

8 mg of any one of the extracts of Preparation Examples 1 to 4, 9 mg of vitamin E, 9 mg of vitamin C, 200 mg of galactooligosaccharide, 60 mg of lactose and 140 mg of maltose were mixed and granulated using a fluidized bed dryer, followed by sugar ester Add 6 mg. 500 mg of these compositions are compressed in a conventional manner to prepare tablets.

[Formulation Example 3] Drink agent

After mixing 8 mg of the extract of any one of Preparation Examples 1 to 4, 9 mg of vitamin E, 9 mg of vitamin C, 10 g of glucose, 0.6 g of citric acid, and 25 g of liquid oligosaccharide, 300 ml of purified water is added, and 200 ml of each bottle is filled. After filling the bottle, it is sterilized at 130° C. for 4 to 5 seconds to prepare a drink.

[Formulation Example 4] Granules

8 mg of any one of the extracts of Preparation Examples 1 to 4, 9 mg of vitamin E, 9 mg of vitamin C, 250 mg of anhydrous crystalline glucose, and 550 mg of starch were mixed, formed into granules using a fluidized bed granulator, and then filled in a bag to prepare granules do.

[Formulation Example 5] Injection

Injections were prepared in a conventional manner according to the composition shown in Table 7 below.

compounding ingredients content The extract of any one of Preparation Examples 1 to 4 10-50 mg Sterile distilled water for injection appropriate amount pH adjuster appropriate amount

[Formulation Example 6] Health functional food

Health functional foods were prepared in a conventional manner according to the composition shown in Table 8 below.

compounding ingredients content The extract of any one of Preparation Examples 1 to 4 20mg vitamin A acetate 70μg vitamin E 1.0mg vitamin B1 0.13mg vitamin B2 0.15mg vitamin B6 0.5mg vitamin B12 0.2μg vitamin C 10mg biotin 10 μg Nicotinamide 1.7mg folic acid 50 μg Calcium Pantothenate 0.5mg ferrous sulfate 1.75mg zinc oxide 0.82mg magnesium carbonate 25.3mg monobasic potassium phosphate 15mg dicalcium phosphate 55mg Potassium Citrate 90mg calcium carbonate 100mg magnesium chloride 24.8mg

The composition ratio of the vitamin and mineral mixture is relatively suitable for health functional food, but the composition is mixed as a preferred example, but the mixing ratio may be arbitrarily modified.

[Formulation Example 7] Health drink

Health drinks were prepared in a conventional manner according to the composition shown in Table 9 below.

compounding ingredients content The extract of any one of Preparation Examples 1 to 4 1000mg citric acid 1000mg oligosaccharide 100 g Taurine 1 g Purified water remaining amount

After mixing the above ingredients according to a conventional health drink manufacturing method, stirring and heating at 85° C. for about 1 hour, the resulting solution is filtered and sterilized.

[Formulation Example 8] Softening lotion (skin lotion)

A softening lotion was prepared in a conventional manner according to the composition shown in Table 10 below.

compounding ingredients content (% by weight) The extract of any one of Preparation Examples 1 to 4 0.2 glycerin 3.0 butylene glycol 2.0 propylene glycol 2.0 Carboxyvinyl Polymer 0.1 PEG-12 Nonylphenyl Ether 0.2 Polysorbate 80 0.4 ethanol 10.0 triethanolamine 0.1 Preservatives, Colors, Flavors appropriate amount Purified water remaining amount

[Formulation Example 9] Nutrient lotion (milk lotion)

Nutrient lotion was prepared in a conventional manner according to the composition shown in Table 11 below.

compounding ingredients content (% by weight) The extract of any one of Preparation Examples 1 to 4 1.0 glycerin 3.0 butylene glycol 3.0 propylene glycol 3.0 Carboxyvinyl Polymer 0.1 beeswax 4.0 Polysorbate 60 1.5 Caprylic/Capric Triglycerides 5.0 squalane 5.0 Sorbitasequioleate 1.5 liquid paraffin 0.5 cetearyl alcohol 1.0 triethanolamine 0.2 Preservatives, Colors, Flavors appropriate amount Purified water remaining amount

[Formulation Example 10] Nourishing Cream

Nutrient creams were prepared in a conventional manner according to the composition shown in Table 12 below.

compounding ingredients content (wt%) The extract of any one of Preparation Examples 1 to 4 2.0 glycerin 3.0 butylene glycol 3.0 liquid paraffin 7.0 beta glucan 7.0 Carbomer 0.1 Caprylic/Capric Triglycerides 3.0 squalane 5.0 cetearyl glucoside 1.5 Sorbitan Stearate 0.4 Polysorbate 60 1.2 triethanolamine 0.1 Preservatives, Colors, Flavors appropriate amount Purified water remaining amount

[Formulation Example 11] Massage Cream

A massage cream was prepared in a conventional manner according to the composition shown in Table 13 below.

compounding ingredients content (wt%) The extract of any one of Preparation Examples 1 to 4 2.0 glycerin 8.0 butylene glycol 4.0 liquid paraffin 45.0 beta glucan 7.0 Carbomer 0.1 Caprylic/Capric Triglycerides 3.0 beeswax 4.0 cetearyl glucoside 1.5 Sesqui oleate sorbitan 0.9 Vaseline 3.0 paraffin 1.5 Preservatives, Colors, Flavors appropriate amount Purified water remaining amount

[Formulation Example 12] Preparation of hair lotion

A hair lotion is prepared according to a conventional method with the composition shown in Table 14 below.

ingredient content (wt%) The extract of any one of Preparation Examples 1 to 4 2.0 Purified water remaining amount glycerin 3.0 Butylene glycol 3.0 liquid paraffin 7.0 beta glucan 7.0 Carbomer 0.1 edelweiss extract 2.0 Caprylic Capric Triglyceride 3.0 squalene 5.0 Cetearyl Grucoside 1.5 Sorbitan Stearate 0.4 polysorbate 1.2 antiseptic appropriate amount incense appropriate amount pigment appropriate amount triethanolamine 0.1

As the specific parts of the present specification have been described in detail above, for those of ordinary skill in the art, these specific techniques are only preferred embodiments, and it is clear that the scope of the present specification is not limited thereto. Accordingly, the substantial scope of the present specification will be defined by the appended claims and their equivalents.

Claims (16)

Contains colored barley extract as an active ingredient,
The colored barley is, at least one selected from the group consisting of amethyst, jeomchal, ganghocheong and Jeju barley, a food composition for inhibiting scalp itchiness. delete The method of claim 1, wherein the colored barley is at least one composition selected from the group consisting of colored barley, Naeyeong, Oeyeong, and Younggwa; The composition of claim 1, wherein the extract is at least one extract selected from the group consisting of water, an organic solvent, and mixtures thereof. The composition of claim 4, wherein the organic solvent is at least one selected from the group consisting of ethanol, butylene glycol, and propylene glycol. The composition of claim 1, wherein the extract is included in an amount of 0.001 to 50% by weight based on the total weight of the composition. The composition of claim 6, wherein the extract is included in an amount of 0.1 to 1% by weight based on the total weight of the composition. Contains colored barley extract as an active ingredient,
The colored barley is at least one selected from the group consisting of amethyst reconnaissance, jeomchal, ganghocheong and Jeju barley, a cosmetic composition for inhibiting scalp itchiness. delete The method of claim 8, wherein the colored barley is at least one composition selected from the group consisting of colored barley, Naeyeong, Oeyeong, and Younggwa; The composition of claim 8, wherein the extract is at least one extract selected from the group consisting of water, an organic solvent, and mixtures thereof. The composition of claim 11, wherein the organic solvent is at least one selected from the group consisting of ethanol, butylene glycol, and propylene glycol. The composition of claim 8, wherein the extract is included in an amount of 0.001 to 50% by weight based on the total weight of the composition. The composition of claim 13, wherein the extract is included in an amount of 0.1 to 1% by weight based on the total weight of the composition. 15. The formulation according to any one of claims 8 and 10 to 14, wherein the composition is selected from the group consisting of hair tonic, hair nourishing lotion, scalp treatment, hair treatment, hair rinse, hair shampoo and hair lotion. phosphorus composition. Contains colored barley extract as an active ingredient,
The colored barley is at least one selected from the group consisting of amethyst, jewels, ganghocheong, and Jeju barley,
A pharmaceutical composition for preventing or treating scalp itchiness.