KR102234670B1 - Cosmetic composition comprising squalene and snail egg extract for preventing and improving striae gravidarum - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising squalene and a snail egg extract. The squalene and snail egg extract have excellent preventing or alleviating function of striae gravidarum, and have no skin toxicity, thereby being easily used to alleviate the skin conditions of pregnant women.

Description

Cosmetic composition comprising squalene and snail egg extract for preventing and improving striae gravidarum}

The present invention relates to a cosmetic composition for preventing or improving stretch marks containing squalene and snail egg extract.

The striae gravidarum refers to striae distensae or stretch marks that appear before and after pregnancy, appearing in the form of wavy pink or purple lines on the belly, chest, and buttocks, sometimes accompanied by itching. The cause of striae gravidarum is known to occur when the normal elasticity of the skin decreases due to an increase in corticosteroids and excessive weight gain due to pregnancy. These striae are known to be more likely to occur in people who are overweight or have weak subcutaneous tissue, and the time when striae glands appear may also appear in the 5th to 6th month of pregnancy, but in some cases, it is reported that it may occur in the late pregnancy. Specifically, epithelial skin is atrophy, and collagen fibers are thinned in dermal skin and are rearranged parallel to the skin. When the striae occurs, the force that pulls the skin is physically split by the lack of elasticity of the outermost phospholipid membrane in the skin tissue. The striae glands that occurred before and after pregnancy do not disappear after delivery, and the cracked skin remains without cosmetic or dermatological regeneration, so that it maintains an unfavorable shape on the appearance of the skin, or even worsens the skin condition during breastfeeding after delivery. It is known that there are cases.

In general, for the treatment of striae gland, a formulation containing retinoic acid such as tretinoin is used to relieve striae gland, but peeling using glycolic acid or trichloroacetic acid. It is also expected to improve the striae gland. In recent years, various lasers have been attempted to improve the striae gland, and there are also attempts to treat and improve a variety of striae gland such as high frequency treatment. However, these methods require a lot of cost and time, and if they are not continuously managed from the beginning of pregnancy to after delivery, there are more cases where practical effects cannot be obtained.

The present inventors have completed the present invention by confirming that a mixture of squalene and an extract of snail roe is effective in preventing and improving the formation of striae gland, while researching on various compositions capable of improving the striae gland.

Republic of Korea Patent Laid-Open Patent No. 10-2016-0143017 (Name of invention: cosmetic composition containing peptide as an active ingredient, Applicant: BMG Co., Ltd. and two others, Publication date: December 14, 2016) Republic of Korea Patent Publication No. 10-2015-0105550 (Name of invention: cosmetic composition containing mucus extract of animal eggs, Applicant: Newmedion, Inc., Publication date: September 17, 2015)

An object of the present invention is to provide a cosmetic composition for preventing or improving stretch marks containing squalene and snail extract.

The present invention relates to a cosmetic composition for preventing or improving stretch marks containing squalene and snail egg extract.

Olive oil wax may be included as an emulsifier in the cosmetic composition.

In addition, as a moisturizing agent, rosehip oil, jojoba oil, shea butter, dimethicone, and glycerin may be included. In addition, Carbomer 940 as a thickener, disodium IDTA as a stabilizer, triethanolamine as an alkali agent, 1,2-hexanediol and ethylhexyl glycerin as a preservative, and lavender essential oil as a fragrance may be added. Water can be added.

Preferably, in the cosmetic composition, 3 to 5% by weight of squalene, 3 to 5% by weight of snail roe extract, 10 to 15% by weight of olive oil wax, 0.005 to 0.05% by weight of rosehip oil, 1 to 3% by weight of jojoba oil, shea butter 0.05 to 0.5 wt%, dimethicone 0.1 to 1 wt%, glycerin 1 to 5 wt%, carbomer 940 0.1 to 0.5 wt%, disodium EDTA 0.005 to 0.1 wt%, triethanolamine 0.1 to 0.5 wt%, 1 ,2-hexanediol 0.1-1 wt%, ethylhexyl glycerin 0.05-0.5 wt%, lavender essential oil 0.01-0.1 wt%, water 65-80 wt% may be included.

The cosmetic composition is preferably characterized in that the cream formulation.

Hereinafter, the present invention will be described in detail.

The olive oil wax is a PEG (polyethylene glycol)-free oil-in-water (O/W) emulsifier derived from olive oil. The lavender essential oil is oil condensed in a cooler after fumigation of lavender flowers. The rosehip oil and jojoba oil are referred to as carrier oils and may be obtained by compressing a raw material sample. The shea butter may be extracted from the fruit of the shea tree. The dimethicone is also referred to as dimethysiloxane, has a structure as shown in the following formula, and n is 3 to 650 in the following formula.

The carbomer used in the present invention is also called carboxyvinyl polymer, and is a polyacrylic acid, as an acrylate/C10-30 alkyl acrylate crosspolymer (Acrylates/C10-30Alkyl Acrylate Cros/spolymer), and has a weight average molecular weight of 400,000 to 5,000,000 ( More preferably 3,000,000 to 5,000,000), and may have a viscosity of 40,000 to 60,000 cps (centipoises). Carbomer or Carbopol series may be used as these, and more preferably Carbomer 940 or Carbomer 980 may be used as carbomer. In the present invention, Carbomer 940 was used.

It is recommended to use eggs within 10 days of spawning the snail eggs used in the present invention. Although the eggs may be used as they are, it is preferable to use them after drying, and preferably, a sample dried by a freeze-drying method is preferably used.

The snail egg extract can be extracted using water, C1 ~ C4 alcohol, propylene glycol, butylene glycol or a mixed solution thereof as a solvent, and the C1 ~ C4 alcohol is methanol, ethanol, propanol, isopropanol, butanol And it may be selected from the group consisting of isobutanol.

Water, C1 ~ C4 alcohol, propylene glycol, butylene glycol, or a mixed solution thereof used in the preparation of the snail roe extract may be 1 ~ 40 times the volume (1 ~ 40 ℓ per 1 kg) based on the weight of the snail roe extract used. , Preferably, 5 to 40 times the volume may be used. The extraction conditions of the snail egg extract may be 1 minute to 48 hours at 20 to 100 ℃. The process can be repeated up to 1 to 4 times. As the extraction solvent, preferably 10 to 30 parts by weight of propylene glycol and 10 to 30 parts by weight of ethanol based on 50 parts by weight of water may be used, and the dry powder of snail eggs is contained in 5 to 20% by weight in the extraction solvent for extraction It is good to be.

In addition, as a conventional method in the art, the group consisting of n-hexane, methylene chloride, acetone, chloroform, ethyl acetate, and n-butanol after dissolving the snail egg water, C1-C4 alcohol or a mixed solution extract thereof in water It can be prepared as a fraction by additional fractionation using one or more solvents selected from.

In another method, the snail eggs are extracted and concentrated with water, C1 ~ C4 alcohol or a mixed solvent thereof, and then suspended by adding water, preferably 1 to 1000 times the weight of the snail egg extract, Snails obtained by adding a solvent selected from the group consisting of hexane, chloroform, ethyl acetate, and butanol to the suspension after suspension by adding more preferably 1 to 500 times, most preferably 1 to 50 times water It can be prepared as an egg fraction.

As a device for extracting the extract or a fraction thereof, a conventional extraction device, an ultrasonic grinding extractor, or a fractionator may be used. The snail roe extract or fraction thus prepared may be dried with hot air, dried under reduced pressure or freeze-dried to remove the solvent. In addition, the snail eggs may be purified and used using column chromatography.

The snail roe extract is a known method used for separating and extracting plant components, such as extraction with an organic solvent (alcohol, ether, acetone, etc.), distribution of hexane and water, and column chromatography according to a commercial method. It can be used after fractionation or purification using an appropriately combined method.

The chromatography includes silica gel column chromatography, LH-20 column chromatography, ion exchange resin chromatography, and medium pressure liquid chromatography. chromatography), thin layer chromatography (TLC), silica gel vacuum liquid chromatography, and high performance liquid chromatography.

The formulation of the cosmetic composition is It can be prepared in any formulation conventionally prepared in the art, and essence, lotion, emulsion, pack, hand cream, foot cream, lip balm, lipstick, eye shadow, eye liner, eyebrow pencil, blusher, highlighter, general Lotion, skin, cream, serum, beauty soap, softening lotion, medicinal lotion, body cleaner, cleansing foam, cleansing lotion, gel, cleansing oil, cleansing cream, shampoo, conditioner, hair treatment, hair lotion, cleansing tissue and cleansing water You can offer a choice from.

The cosmetic composition of the present invention may further include a component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingo lipids, and seaweed extract.

The water-soluble vitamin may be any one that can be blended in cosmetics, but preferably vitamin B1, vitamin B2, vitamin B6, pyridoxine, pyridoxine hydrochloride, vitamin B12, pantothenic acid, nicotinic acid, nicotinic acid amide, folic acid, vitamin C, vitamin H, etc. And their salts (thiamine hydrochloride, sodium ascorbate, etc.) and derivatives (ascorbic acid-2-phosphate sodium salt, ascorbic acid-2-magnesium salt, etc.) can also be used in the water-soluble vitamins that can be used in the present invention. Included. Water-soluble vitamins can be obtained by conventional methods such as a microbial transformation method, a purification method from a culture of microorganisms, an enzyme method, or a chemical synthesis method.

The oil-soluble vitamin may be any one that can be blended into a cosmetic, but preferably vitamin A, carotene, vitamin D2, vitamin D3, vitamin E (DL-alpha tocopherol, D-alpha tocopherol, D-alpha tocopherol), etc. are mentioned. , Their derivatives (ascorbine palmitate, ascorbine stearate, ascorbine dipalmitate, dl-alpha tocopherol acetate, dl-alpha tocopherol nicotinic acid, vitamin E, DL-pantotenyl alcohol, D-pantotenyl alcohol, pantotenyl ethyl Ether, etc.) are also included in the oil-soluble vitamin used in the present invention. Oil-soluble vitamins can be obtained by conventional methods such as a microbial transformation method, a purification method from a culture of microorganisms, an enzyme or chemical synthesis method.

The polymeric peptide may be any one as long as it can be blended into the cosmetic composition, but preferably, collagen, hydrolyzed collagen, gelatin, elastin, hydrolyzed elastin, keratin, and the like are exemplified. The polymeric peptide can be purified and obtained by a conventional method such as a purification method from a culture medium of a microorganism, an enzyme method, or a chemical synthesis method, or it can be used after being purified from natural products such as dermis of pigs and cattle, silk fibers of silkworms, etc.

The polymer polysaccharide may be any one as long as it can be blended into the cosmetic composition, but preferably, hydroxyethyl cellulose, xanthan gum, sodium hyaluronate, chondroitin sulfuric acid or a salt thereof (sodium salt, etc.) may be mentioned. For example, chondroitin sulfate or a salt thereof can be used after being purified from mammals or fish.

The sphingo lipid may be any one as long as it can be blended in the cosmetic composition, but preferably, ceramide, phytosphingosine, sphingoglycolipid, and the like are exemplified. Sphingo lipids are usually purified from mammals, fish, shellfish, yeast, plants, etc. by a conventional method or can be obtained by chemical synthesis.

The seaweed extract may be any one as long as it can be blended into the cosmetic composition, but preferably, brown algae extract, red algae extract, green algae extract, etc. are exemplified, and carrageenan, arginic acid, sodium arginate purified from these seaweed extracts , Potassium arginate and the like are also included in the seaweed extract used in the present invention. Seaweed extract can be obtained by purifying from seaweed by a conventional method.

In the cosmetic composition of the present invention, other ingredients to be blended in conventional cosmetics may also be blended.

Other ingredients that may be added include fats and oils, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, fragrances, Blood circulation accelerators, cold sensation agents, restrictors, and purified water.

Examples of oil and fat components include ester oils and fats, hydrocarbon oils, silicone oils, fluorine oils, animal oils and vegetable oils.

As ester-based fats and oils, tri2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, stearic acid Butyl, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine Diisopropyl acid, isoalkyl neopentanoate, glyceryl tri(caprylic, capric acid) glyceryl, trimethylolpropane tri2-ethylhexanoate, trimethylolpropane triisostearate, pentaelisitol tetra2-ethylhexanoate , Cetyl caprylate, decyl laurate, hexyl laurate, decyl myristic acid, myristic myristic acid, cetyl myristate, stearyl stearate, decyl oleate, ricinooleate, isostea laurate Reel, isotridecyl myristate, isocetyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl linoleate, isopropyl isostearate, 2-ethylhexanoate cetoste Aryl, 2-ethylhexanoate stearyl, isostearate hexyl, dioctanoate ethylene glycol, dioleate ethylene glycol, dicaprylic acid propylene glycol, dicaprylic acid propylene glycol, dicaprylic acid propylene glycol, dica Neopentyl glycol prinate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, glyceryl triisopalmitate, glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate , Octyl isononanoate, hexyldecyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerololeic acid ester, polyglycerin isostearic acid ester, Triisocetyl citrate, triisoalkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyldecyl lactate, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, di malic acid Isostearyl, 2-ethylhexyl hydroxystearate, di2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, Cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, pitsteryl isostearate, pitsteryl oleate, 12-stealoyl And esters such as isocetyl hydroxystearate, stearyl 12-stealoylhydroxystearate, and isostearyl 12-stealoylhydroxystearate.

Examples of hydrocarbon-based fats and oils include hydrocarbon-based fats such as squalene, liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybuden, microcrystalline wax, and petrolatum.

Silicone-based fats and oils include polymethylsilicone, methylphenylsilicone, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane/methylcetyloxysiloxane copolymer, dimethylsiloxane/methylsteaoxysiloxane copolymer, alkyl And modified silicone oil and amino-modified silicone oil.

As fluorine-based fats and oils, perfluoropolyether, etc. are mentioned.

Animal or plant oils include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, bird flower oil, soybean oil, corn oil, rapeseed oil, almond oil, palm kernel oil, palm oil, castor oil, sunflower oil, grape seed oil. , Cottonseed Oil, Palm Oil, Cucuine Nut Oil, Wheat Germ Oil, Rice Germ Oil, Shea Butter, Walnut Colostrum Oil, Marker Demi Anut Oil, Meadow Home Oil, Egg Yolk Oil, Tallow Oil, Horse Oil, Mink Oil, Orange Lapi Oil, Jojoba Oil , Animal or plant fats such as canderry wax, carnauba wax, liquid lanolin, and hydrogenated castor oil.

Examples of the moisturizing agent include a water-soluble low-molecular moisturizer, a fat-soluble molecular moisturizer, a water-soluble polymer, and a fat-soluble polymer.

As water-soluble low molecular weight moisturizers, serine, glutamine, sorbitol, mannitol, pyrrolidone-sodium carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B (polymerization degree n = 2 or more), polypropylene Glycol (polymerization degree n = 2 or more), polyglycerin B (polymerization degree n = 2 or more), lactic acid, lactate, and the like.

As a fat-soluble low molecular weight moisturizer, cholesterol, cholesterol ester, etc. are mentioned.

Examples of water-soluble polymers include carboxyvinyl polymer, polyaspartic acid salt, tragacanth, xanthan gum, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, water-soluble chitin, chitosan, dextrin, and the like. I can.

Examples of the oil-soluble polymer include polyvinylpyrrolidone/eicosene copolymer, polyvinylpyrrolidone/hexadecene copolymer, nitrocellulose, dextrin fatty acid ester, and polymer silicone.

Examples of the emollient agent include long-chain acyl glutamate cholesteryl ester, hydroxystearate cholesteryl, 12-hydroxystearic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl ester, and the like.

Examples of the surfactant include nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, and the like.

Nonionic surfactants include self-emulsifying glycerin monostearate, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerol fatty acid ester, sorbitan fatty acid ester, POE (polyoxyethylene) sorbitan fatty acid ester, POE sorbit fatty acid ester, POE Glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hydrogenated castor oil, POE castor oil, POE·POP (polyoxyethylene·polyoxypropylene) copolymer, POE·POP alkyl ether, polyether-modified silicone, lauric acid Alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, etc. are mentioned.

As anionic surfactants, fatty acid soap, alpha-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate, alkyl amide sulfate, alkyl phosphate, POE alkyl phosphate, alkyl amide Phosphate, alkyloylalkyltaurine salt, N-acylamino acid salt, POE alkylether carboxylate, alkylsulfosuccinate, sodium alkylsulfoacetate, acylated hydrolyzed collagen peptide salt, perfluoroalkylphosphoric acid ester, etc. have.

Cationic surfactants include alkyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, cetostearyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyldimethylbenzyl ammonium chloride, behenyl trimethyl ammonium bromide, and chloride. Benzalkonium, diethylaminoethyl amide stearate, dimethylaminopropyl amide stearate, lanolin derivative quaternary ammonium salt, and the like.

Examples of amphoteric surfactants include carboxybetaine type, amidebetaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amideamine type, etc. And amphoteric surfactants.

As organic and inorganic pigments, silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, bengala, clay, bentonite, titanium coated mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, aluminum oxide , Inorganic pigments such as calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine, chromium oxide, chromium hydroxide, calamine, and complexes thereof; Polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, divinylbenzene-styrene copolymer, Organic pigments, such as silk powder, cellulose, CI pigment yellow, and CI pigment orange, and complex pigments of these inorganic pigments and organic pigments, etc. are mentioned.

Examples of the organic powder include metal soaps such as calcium stearate; Alkyl phosphate metal salts, such as sodium zinc cetylate, zinc laurylate, and calcium laurylate; Acylamino acid polyvalent metal salts, such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc, and N-lauroyl glycine calcium; Amide sulfonic acid polyvalent metal salts such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; N, such as N-epsilon-lauroyl-L-lysine, N-epsilon-palmitoyl lizine, N-alpha-paritoylolnitine, N-alpha-lauroylarginine, N-alpha-hardened tallow fatty acid acylarginine, etc. -Acyl basic amino acid; N-acyl polypeptides such as N-lauroylglycylglycine; Alpha-amino fatty acids such as alpha-aminocaprylic acid and alpha-aminolauric acid; Polyethylene, polypropylene, nylon, polymethyl methacrylate, polystyrene, divinylbenzene/styrene copolymer, ethylene tetrafluoride, and the like.

UV absorbers include paraaminobenzoic acid, ethyl paraaminobenzoate, amyl paraaminobenzoate, octyl paraaminobenzoate, ethylene glycol salicylate, phenyl salicylate, octyl salicylate, benzyl salicate, butyl phenyl salicylate, homomentyl salicylate, benzyl cinnamate. , Paramethoxycinnamic acid-2-ethoxyethyl, paramethoxycinnamic acid octyl, diparamethoxycinnamic acid mono-2-ethylhexane glyceryl, paramethoxycinnamic acid isopropyl, diisopropyl·diisopropyl cinnamic acid ester mixture, right Cannic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid and salts thereof, dihydroxymethoxybenzophenone, sodium dihydroxymethoxybenzophenone disulfonate, dihydroxybenzophenone , Tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxydibenzoylmethane, 2,4,6-trianilino-p-(carbo-2'-ethylhexyl-1'-oxy)-1 ,3,5-triazine, 2-(2-hydroxy-5-methylphenyl)benzotriazole, etc. are mentioned.

As a disinfectant, hinokitiol, triclosan, trichlorohydroxydiphenyl ether, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, zinpyrthione, benzalkonium chloride, photosensitization Sodium No. 301, mononitroguayol sodium, undecylenic acid, etc. are mentioned.

Examples of the antioxidant include butylhydroxyanisole, propyl gallic acid, and elisorbic acid.

Examples of the pH adjuster include citric acid, sodium citrate, malic acid, sodium malate, pmaric acid, sodium pmarate, succinic acid, sodium succinate, sodium hydroxide, sodium monohydrogen phosphate, and the like.

Examples of alcohol include higher alcohols such as cetyl alcohol.

In addition, the blending ingredients that may be added are not limited thereto, and any of the above ingredients can be blended within a range that does not impair the object and effect of the present invention, but is preferably 0.01 to 5% by weight, more preferably, based on the total weight. May be blended in 0.01-3% by weight.

The cosmetic composition of the present invention may take the shape of a solution, an emulsion, a viscous mixture, or the like.

Ingredients included in the cosmetic composition of the present invention may include ingredients commonly used in cosmetics in addition to the extract as an active ingredient, and for example, conventional adjuvants such as stabilizers, solubilizers, vitamins, pigments and fragrances, and It includes a carrier.

When the formulation of the cosmetic composition of the present invention is a paste, cream or gel, animal fibers, plant fibers, wax, paraffin, starch, tracant, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc, or zinc oxide are used as carrier components. Can be used.

When the cosmetic composition formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additional chlorofluorohydrocarbons , Propane/butane or dimethyl ether.

When the cosmetic composition formulation of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol , 1,3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan.

When the cosmetic composition formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Crystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, and the like may be used.

When the cosmetic composition formulation of the present invention is a surfactant containing cleansing, as carrier components, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, Fatty acid amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linoline derivatives or ethoxylated glycerol fatty acid esters may be used.

The present invention relates to a cosmetic composition containing squalene and snail roe extract, and the squalene and snail roe extract has excellent function of preventing or improving striatum and has no skin toxicity, so it can be easily used for improving the skin condition of pregnant women. .

FIG. 1 is a result of measuring the number of mothers having the most (reduced by 4 to 8% on a chromameter) effect of preventing striatum among mothers before delivery using the cream-formed cosmetic composition of the present invention.
FIG. 2 is a result of measuring the number of mothers having the most (reduced by 4 to 8% on a chromameter) effect of preventing striatum among the mothers after delivery using the cream-formed cosmetic composition of the present invention.

Hereinafter, a preferred embodiment of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, it is provided to sufficiently convey the spirit of the present invention to those skilled in the art so that the contents introduced herein are thorough and complete.

<Preparation Example 1. Preparation of squalene and snail egg extract>

Squalene was prepared as it is in an undiluted state by purchasing a product of Squalene (trade name; Supraene) from ROBECO Inc.

The snail egg extract was prepared by the following method. Healthy and clean snail eggs within about 10 days after spawning were selected, washed several times in clean flowing water, washed three times with distilled purified water, and then frozen using a freeze dryer for preservation. A crushed mixture was prepared by mixing 10% (w/w) of freeze-dried snail dry powder into 20% (w/w) propylene glycol, 20% (w/w) ethanol, and 50% (w/w) water. Then, the extract was heated and mixed at 80° C. for 3 hours to extract, and the extracted snail egg extract was first filtered with 8-12 μm filter paper and then filtered second with 3-5 μm filter paper, and then a snail egg extract was obtained.

[Examples 1 to 8 and Comparative Examples 1 to 21]

In order to confirm the improvement and prevention effect of the cream formulation of the present invention containing squalene and snail roe extract, the improvement of pregnancy height in Examples 1 to 8 and Comparative Examples 1 to 21 in the composition shown in Tables 1 to 4 below And to prepare a cream formulation cosmetic composition for prevention.

Raw materials used
(Based on total weight of 100g, unit %) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Functional
additive Squalene 3.00 3.00 5.00 5.00 4.00 4.00 4.00 4.00 Snail Egg Extract 3.00 5.00 3.00 5.00 4.00 4.00 4.00 4.00 Emulsifier Olive oil wax 12.00 12.00 12.00 12.00 10.00 15.00 13.00 14.00 Moisturizer Rosehip oil 0.01 0.01 0.01 0.01 0.01 0.01 0.005 0.05 Jojoba Oil 2.00 2.00 2.00 2.00 1.50 2.50 3.00 1.00 Shea Butter 0.10 0.10 0.10 0.10 0.05 0.10 0.50 0.1 Dimethicone 0.50 0.50 0.50 0.50 0.30 0.10 0.7 1.00 glycerin 3.00 3.00 3.00 3.00 5.00 3.00 1.00 2.00 Thickener Carbopol 0.20 0.20 0.20 0.20 0.30 0.10 0.4 0.5 Stabilizer Disodium EDTA 0.02 0.02 0.02 0.02 0.10 0.01 0.05 0.005 Alkaline agent Triethanolamine 0.20 0.20 0.20 0.20 0.50 0.10 0.30 0.4 antiseptic 1,2-hexanediol 0.50 0.50 0.50 0.50 0.30 0.10 0.70 1.00 Ethylhexyl glycerin 0.10 0.10 0.10 0.10 0.50 0.30 0.05 0.07 Spices Lavender oil 0.05 0.05 0.05 0.05 0.03 0.01 0.07 0.10 Ultrapure water Purified water Balance Balance Balance Balance Balance Balance Balance Balance

Raw materials used
(Based on total weight of 100g, unit %) Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Functional
additive Squalene - 1.00 2.00 3.00 4.00 5.00 - Snail Egg Extract - - - - - - 1.00 Emulsifier Olive oil wax 12.00 12.00 12.00 12.00 12.00 12.00 12.00 Moisturizer Rosehip oil 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Jojoba Oil 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Shea Butter 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Dimethicone 0.50 0.50 0.50 0.50 0.50 0.50 0.50 glycerin 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Thickener Carbopol 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Stabilizer Disodium EDTA 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Alkaline agent Triethanolamine 0.20 0.20 0.20 0.20 0.20 0.20 0.20 antiseptic 1,2-hexanediol 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Ethylhexyl glycerin 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Spices Lavender oil 0.05 0.05 0.05 0.05 0.05 0.05 0.05 Ultrapure water Purified water Balance Balance Balance Balance Balance Balance Balance

Raw materials used
(Based on total weight of 100g, unit %) Comparative Example 8 Comparative Example 9 Comparative Example 10 Comparative Example 11 Comparative Example 12 Comparative Example 13 Comparative Example 14 Functional
additive Squalene - - - - 1.00 2.00 10.00 Snail Egg Extract 2.00 3.00 4.00 5.00 2.00 1.00 - Emulsifier Olive oil wax 12.00 12.00 12.00 12.00 12.00 12.00 12.00 Moisturizer Rosehip oil 0.01 0.01 0.01 0.01 0.01 0.01 0.01 Jojoba Oil 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Shea Butter 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Dimethicone 0.50 0.50 0.50 0.50 0.50 0.50 0.50 glycerin 3.00 3.00 3.00 3.00 3.00 3.00 3.00 Thickener Carbopol 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Stabilizer Disodium EDTA 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Alkaline agent Triethanolamine 0.20 0.20 0.20 0.20 0.20 0.20 0.20 antiseptic 1,2-hexanediol 0.50 0.50 0.50 0.50 0.50 0.50 0.50 Ethylhexyl glycerin 0.10 0.10 0.10 0.10 0.10 0.10 0.10 Spices Lavender oil 0.05 0.05 0.05 0.05 0.05 0.05 0.05 Ultrapure water Purified water Balance Balance Balance Balance Balance Balance Balance

Raw materials used
(Based on total weight of 100g, unit %) Comparative Example 15 Comparative Example 16 Comparative Example 17 Comparative Example 18 Comparative Example 19 Comparative Example 20 Comparative Example 21 Functional
additive Squalene - 4.00 3.00 3.00 3.00 3.00 3.00 Snail Egg Extract 10.00 4.00 3.00 3.00 3.00 3.00 3.00 Emulsifier Olive oil wax 12.00 20.00 5.00 5.00 - 20.00 12.00 Moisturizer Rosehip oil 0.01 0.10 0.001 - 0.01 1.00 0.01 Jojoba Oil 2.00 4.00 0.50 - 2.00 2.00 10.00 Shea Butter 0.10 1.00 0.01 - 0.10 0.10 2.00 Dimethicone 0.50 1.50 0.05 0.50 - 0.50 3.00 glycerin 3.00 0.50 8.00 3.00 - 10.00 3.00 Thickener Carbopol 0.20 0.05 1.00 0.20 0.20 0.20 0.20 Stabilizer Disodium EDTA 0.02 0.20 0.001 0.02 0.02 0.02 0.10 Alkaline agent Triethanolamine 0.20 0.20 0.20 0.20 0.20 0.20 0.20 antiseptic 1,2-hexanediol 0.50 0.50 0.50 0.50 0.50 2.00 0.50 Ethylhexyl glycerin 0.10 0.10 0.10 0.10 0.10 0.10 2.00 Spices Lavender oil 0.05 0.05 0.05 0.05 - 0.05 0.05 Ultrapure water Purified water Balance Balance Balance Balance Balance Balance Balance

[Experimental Example 1] Measurement of the effect of promoting type 1 procollagen biosynthesis

In order to confirm the effect of promoting type 1 procollagen biosynthesis of a 1:1 equal weight mixture of squalene and snail roe extract, a procollagen assay was performed as follows using TGF-β as a control.

Human dermal fibroblasts isolated from neonatal epidermal tissue were added to DMEM/F-12 (3:1) medium with 10% fetal bovine serum (FBS) to a concentration of ^{1×10 4} cells/cm ² Cultured. When about 70 to 80% of growth was grown, the cells were subcultured at a ratio of 1:3, and the cells passaged 3 to 4 were used in the experiment. For an experiment to measure the amount of procollagen, fibroblasts were cultured in a 48-well plate at least 90%, and then the same weight mixture of squalene and snail extract was added to the cell culture solution at a concentration of 0.01% (w/v). After 24 hours of addition, the amount of free procollagen in the medium was measured, and the results are shown in Table 5 below. At this time, TGF-β 200nM was used as a positive control group, and the group treated with squalene and snail extract alone and the mixture were also presented at the same concentration. Since squalene was included, each sample was dissolved in DMSO and mixed with the cell culture solution.

Sample name Procollagen biosynthesis promotion effect (%) Equal weight mixture of squalene and snail roe extract 91.2 Squalene 24.2 Snail egg extract 31.4 TGF-β (200nM) 85.3

As a result, it was confirmed that the mixture of squalene and snail egg extract produced the most excellent procollagen biosynthesis promoting effect, and thus was suitable for use as a cosmetic composition for preventing or preventing striae.

[Experimental Example 2] Checking the efficacy of the cream formulation

Although the function of preventing or preventing stretch marks of the mixture of squalene and snail roe extract was confirmed through Experimental Example 1, when prepared in the form of a cosmetic formulation, it is often difficult to properly express the function. Therefore, 10 women before delivery and after delivery were grouped, and after applying the cream formulations to these women for 3 months, it was confirmed whether the effect of preventing or preventing striae was properly expressed even on the cosmetic formulation.

The experimental method is to designate the left and right stretch marks of the subject at the site where the sample is applied, and then attach the acetate film to the designated test site and mark a point so that the same area can be measured at each measurement, and a chromameter. It was carried out by evaluating the skin color of the stretch marks area using. Chromameter CR-400 is a device that converts colors perceived by humans into a digital code composed of three factors, and is widely used for skin color measurement in cosmetics research. Each change value is represented by [No change: x], [Slight change (1~3% decrease on the chromameter): +], [Significant change (4~8% decrease on the chromameter): ++] In the corresponding item, the number of the corresponding person out of the total number of 10 people was recorded.

As a result, in each formulation, the result that the striae gland became more severe was not confirmed, so this result was not indicated. As shown in Table 6 and Table 7, the mixed extract of squalene and snail eggs was added to the cosmetic composition, respectively, 3 to 5 In the case of the cream formulation of Examples 1 to 8 in which the weight percent was mixed, 7 to 9 or more of 10 people were confirmed to have the effect of improving and preventing stretch marks before delivery, and 6 to 9 of 10 people for improvement and prevention of stretch marks after delivery. More than one person obtained the results showing the effect.

Before delivery (during pregnancy) Before use
No difference (x) (persons) Slightly improved striae gland (+) (persons) The striae was significantly improved or prevented (++) (persons) Example 1 One 3 6 Example 2 One One 8 Example 3 0 2 8 Example 4 0 One 9 Example 5 0 3 7 Example 6 One One 8 Example 7 One 2 7 Example 8 0 One 9 Comparative Example 1 9 One 0 Comparative Example 2 8 2 0 Comparative Example 3 8 One One Comparative Example 4 2 4 4 Comparative Example 5 One 5 4 Comparative Example 6 0 6 4 Comparative Example 7 10 0 0 Comparative Example 8 8 2 0 Comparative Example 9 3 5 2 Comparative Example 10 One 5 4 Comparative Example 11 0 7 3 Comparative Example 12 5 3 2 Comparative Example 13 3 3 4 Comparative Example 14 4 4 2 Comparative Example 15 4 2 4 Comparative Example 16 4 One 3 Comparative Example 17 6 2 2 Comparative Example 18 5 3 2 Comparative Example 19 8 One One Comparative Example 20 8 2 0 Comparative Example 21 7 3 0

After delivery (postpartum care center) Before use
No difference (x) (persons) Slightly improved striae gland (+) (persons) The striae was significantly improved or prevented (++) (persons) Example 1 One 2 6 Example 2 0 4 8 Example 3 0 4 8 Example 4 0 One 9 Example 5 One 2 7 Example 6 0 2 8 Example 7 0 One 9 Example 8 One 2 7 Comparative Example 1 10 0 0 Comparative Example 2 5 5 0 Comparative Example 3 4 2 2 Comparative Example 4 5 4 One Comparative Example 5 7 2 One Comparative Example 6 9 One 0 Comparative Example 7 9 One 0 Comparative Example 8 8 2 0 Comparative Example 9 5 2 3 Comparative Example 10 3 4 3 Comparative Example 11 7 2 One Comparative Example 12 5 2 3 Comparative Example 13 3 4 3 Comparative Example 14 4 4 2 Comparative Example 15 6 2 2 Comparative Example 16 2 5 3 Comparative Example 17 7 2 One Comparative Example 18 7 2 One Comparative Example 19 7 3 0 Comparative Example 20 8 2 0 Comparative Example 21 7 3 0

Claims (6)

Squalene 3 to 5% by weight, snail roe extract 3 to 5% by weight, olive oil wax 10 to 15% by weight, rosehip oil 0.005 to 0.05% by weight, jojoba oil 1 to 3% by weight, shea butter 0.05 to 0.5% by weight, Dime Chicon 0.1 to 1% by weight, glycerin 1 to 5% by weight, Carbomer 940 0.1 to 0.5% by weight, Disodium IDTA 0.005 to 0.1% by weight, triethanolamine 0.1 to 0.5% by weight, 1,2-hexanediol 0.1 to 1% by weight, ethylhexyl glycerin 0.05 to 0.5% by weight, lavender essential oil 0.01 to 0.1% by weight, a cosmetic composition for preventing or improving striae striae, characterized in that it contains 65 to 80% by weight of water. delete delete delete delete delete

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