KR101956767B1 - Capsule Containing Active Ingredients - Google Patents

Abstract

The present invention relates to a capsule containing an active ingredient and, as a result of containing sodium polyacrylate and an agar as an outer membrane component, the capsule is smooth and uniform in appearance compared to a capsule made of a conventionally used outer membrane component, , It has an effect of improving spreadability and water absorbability, so that the capsule of the present invention can be usefully used in the field of cosmetics.

Description

Capsule Containing Active Ingredients < RTI ID = 0.0 >

The present invention relates to a capsule on which an active ingredient is carried.

Encapsulation refers to wrapping or coating an internal material with a polymer membrane. The outer film of the capsule protects the inner material contained in the capsule from being exposed to oxygen, thereby stably maintaining the inner material and controlling release of the inner material. The internal material may be a liquid, a solid, and a gas may be applied. When the internal material is a liquid, other active ingredients may be dissolved or dispersed. Cosmetics, medicines, vaccines, enzymes, microorganisms, cells, fragrances, oils, insecticides, pigments and the like may be applied as internal materials, and additives or stabilizers such as diluents may be further added.

The constituent material of the outer film of the capsule is a material which is stable when the inner material is embedded with a desired thickness. The outer film component mainly includes an inactive polymer, a softener, a moisturizer, a pigment, and a release rate modifier. For example, alginate, gelatin, carrageenan, cellulose sulfate and chitosan are used.

Capsules have functions of accuracy, timeliness, safety, convenience, functionality, and visual effects, depending on the application. Convenience, functionality and visual effects are particularly important when capsule formulations are used in the cosmetics field. In the case of cosmetics, the physiological activity of the active ingredient contained in the capsules should be maintained. If the visual effects of the capsule formulation are more favorable than those of the other formulations at the time of use, merchandise is enhanced. Therefore, the capsule formulation .

Types of capsules include seamless capsules and seam type capsules. The seamless capsule is manufactured by a dropping method, and a spherical capsule is formed while a solution containing a constituent of an inner material and an outer membrane is discharged through a nozzle, and gelatin, agar, a natural gelling material and the like And the outer film is resistant to heat, acid, and low temperature. In the case of the core type capsule, it is manufactured in a rotary manner, and the inner material is embedded by the outer membrane using the mold. Gelatin and glycerin are used as constituents of the outer membrane, and the outer membrane is known to have no function.

Seamless capsules are made of transparent and glossy spherical capsules, as compared to core type capsules, directly encapsulating the lipid soluble ingredients, and can reduce or increase the size of the capsule itself to control the volume of the internal material. It also functions as a vapor barrier because it prevents oxidation of internal materials. By adding various pigments to the solution containing the components constituting the outer film, the appearance of the capsule can be enhanced by varying the color. In addition, the diameter can be freely adjusted within a range of 1 mm to 8 mm, and the diameter can be adjusted to suit the use of the capsule.

In manufacturing a seamless capsule, a capsule manufacturing apparatus disclosed in Patent Document 1 can be used. The manufacturing apparatus has a double discharge structure in which a path through which a perfume liquid (internal material) is discharged and a path through which a film material (a solution containing components constituting the outer film) is discharged is provided. In addition, the membrane has a nozzle which is discharged in the form of wrapping the perfume liquid to form an initial shape of the perfume capsule, and the coolant is introduced into the lower end of the nozzle, and the capsule is cooled by cooling the perfume. However, in Patent Document 1, only the production of capsules for loading the fragrance of cigarettes is disclosed, and the production of capsules applicable to the field of cosmetics is not disclosed. In order to prepare capsules applicable to cosmetics by using the capsule manufacturing apparatus disclosed in Patent Document 1, examination of the components contained in the outer film or internal substances is required Further, it is necessary. In addition, since the capsule used in Patent Document 1 includes a drying process and a further curing process, it is hard to apply the cosmetic composition to a hard capsule because the outer capsule is hard.

The inventors of the present invention studied the production of a capsules excellent in visual effects while soft capsules are soft to be used as cosmetics, while effectively supporting internal substances, in order to apply seamless capsules to cosmetics. By controlling ingredients constituting the outer film The present invention has been accomplished by confirming that the prepared capsule is a soft capsule having a hardness suitable for application to cosmetics, that the effect of the internal material is maintained, and that it is visually beautiful.

Korea Patent Publication No. 2016-0116827

In the case of capsules conventionally applied to cosmetics, there are problems in that the outer appearance of the capsules is uneven according to the components constituting the outer film of the capsules, and the spreadability and absorbability are low. The present invention aims to provide a seamless capsule having improved appearance of a capsule, excellent spreadability and absorbency.

In order to solve the above-mentioned problems, the present invention relates to an internal substance comprising a cosmetic active ingredient; And an outer film comprising sodium polyacrylate and agar.

The present invention also provides a cosmetic composition comprising the capsule.

The capsules of the present invention can be loaded on a water-soluble raw material (outer film), such as oils, without the use of a surfactant, and the quality of the internal material can be stabilized before use. When the capsules of the present invention are applied to cosmetics, Compared with the outer membrane component used, it has increased wettability and absorbency, and since the outer film of the capsule is transparent, the color of the capsule can be changed according to the inner substance, so that the visual effect is excellent.

Fig. 1 shows the appearance of the capsules prepared in Examples 1 and 2. Fig.
Fig. 2 shows cosmetics to which the capsules prepared in Examples 1 and 2 are applied. Fig.
Fig. 3 is a photograph of a shape when the capsule prepared in each of Examples 1 and 2 is poured onto glass after being loaded in a container.
Fig. 4 shows a state in which the pumped product of Fig. 3 is spread on glass.
Fig. 5 shows a state in which capsules prepared in Comparative Examples 1 and 2 were respectively pumped and spread on glass.

Hereinafter, the present invention will be described in detail.

The present invention relates to an internal substance comprising a cosmetic active ingredient; And an outer film comprising sodium polyacrylate and agar.

The outer film may further include hyaluronic acid, but is not limited thereto. By including hyaluronic acid in the outer membrane, the physical properties of the capsule outer membrane, such as elasticity, are excellent and the elasticity of the capsule is maintained even if the capsule is naturally dried for a predetermined time. Also, a moisturizing effect can be obtained. Even when the outer film contains hyaluronic acid, sodium polyacrylate and agar, it is excellent in spreadability.

The sodium polyacrylate and the agar may be contained in an amount of 0.01 to 10 parts by weight, preferably 0.1 to 10 parts by weight, preferably 0.05 to 8 parts by weight, and 0.3 to 8 parts by weight, And more preferably 0.1 part by weight to 5 parts by weight: 0.5 part by weight to 5 parts by weight, but is not limited thereto. More preferably, sodium polyacrylate and agar may be contained in an amount of 0.1 parts by weight to 1.5 parts by weight: 0.5 parts by weight to 1.5 parts by weight, but are not limited thereto.

As the sodium polyacrylate is used in the above range, the outer film of the capsules prepared by modifying the outer film component of the agar, which is added together, is smooth and the function of the inner material can be maintained for a long time because the inner material is not leaked. When sodium polyacrylate is contained below the lower limit value, the coagulation bond strength of the agar added together is affected, and the capsules are not formed perfectly, resulting in a large variation in the hardness and size of the capsules to be produced. Further, the bonding force is weak in the outer film, and the function of the inner material is not maintained for a long time. When the sodium polyacrylate is contained in an amount exceeding the upper limit, there is a problem in ejecting from the nozzle because the viscosity of the formulation is high.

When the agar is contained below the lower limit value, since the main ingredient for forming the outer membrane is insufficient, the capsule is not formed into a spherical shape, the internal substance is not supported, and the capsule is leaked out. The objective is not achieved. Also, in view of visual effects, one of the objects of the present invention, when the agar is included below the lower limit value, since the capsule hardness is low, the appearance of the capsule is not maintained during the application to the cosmetic container or during the transportation, Therefore, the object of the present invention can not be sufficiently achieved. When the agar is contained in excess of the upper limit value, the viscosity of the formulation is high, and there may be a problem in discharging from the nozzle or a feeling of foreign body may be felt when the capsule is applied to the formulation.

The internal material may comprise at least one selected from the group consisting of a lipophilic component, a water / oil (W / O) formulation, and a water / silicon (W / S) May include, but is not limited to, at least one of a liposoluble component and a W / O formulation.

The fat-soluble component may be an oil derived from a plant, a carrier oil, a silicone oil, an emollient oil, a flavor, a fat-soluble vitamin, a fat-soluble pigment, a fat-soluble active substance, and the like.

The oil derived from the plant may be selected from the group consisting of red ginseng oil, avocado oil, wheat germ oil, rosehip oil, almond oil, olive oil, sesame oil, black sesame oil, castor oil, camellia oil, safflower oil, soybean oil, rapeseed oil, , Plant extract oil selected from peanut oil, macadamia nut oil, jojoba oil, palm oil, palm kernel oil, coconut oil, rice bran oil and grape seed oil, but is not limited thereto.

Examples of the fat-soluble active substance include retinol, retinol derivatives, retinyl acetate, retinyl palmitate, tocopherol, tocopheryl acetate, tocopheryl linolate, tocopheryl nicotinate, epigallocatechin gallate, Lysine, coenzyme Q-10, resveratrol, and derivatives thereof, or combinations thereof, but are not limited thereto.

The W / O or W / S formulations applicable to the present invention may have a low viscosity of 200-1000 CPS or less, but are not limited thereto. Examples of low viscosity W / O or W / S formulations include, but are not limited to, sunscreens, foundations, baboons, seed creams, makeup bases, lotions, essences, creams and color cosmetics.

The W / S formulation refers to a formulation in which the silicone oil is emulsified while water is surrounded by a lipophilic emulsifier as a mediator between silicone oil and water. Generally, when the W / S formulation is used as the raw material, the oil phase may be separated when the product is used after distribution / storage. Particularly, when the silicone oil is a cyclic silicone oil, it has high volatility and has a problem of good separation. In the case of the capsules of the present invention, the W / S formulation can be supported in capsules to suppress the volatilization of the oil, thereby reducing the phenomenon of separation of the oil phase.

The size of the capsule may be 1 mm to 8 mm, preferably 1.5 mm to 7 mm, and more preferably 2 mm to 6 mm, but is not limited thereto.

The cosmetics to which the capsules of the present invention are applied may include bases, adjuvants and preservatives conventionally used in the field of cosmetics and are not particularly limited and include water, alcohol, propylene glycol, stearic acid, glycerol, cetyl alcohol, And ethanol.

When the capsule of the present invention is contained in a cosmetic composition, the cosmetic composition may contain components commonly used in cosmetic compositions and may contain conventional additives such as antioxidants, stabilizers, solubilizers, vitamins, pigments and perfumes, And may include a carrier.

The cosmetic composition containing the capsules of the present invention may be used alone or in combination, or may be used by overlapping with other cosmetic compositions other than the present invention. The cosmetic composition containing the capsules according to the present invention may be used in accordance with a conventional method of use, and may be used in a number of times depending on the skin condition or taste of the user.

Hereinafter, the present invention will be described in detail with reference to examples.

However, the following examples are for illustrative purposes only and are not intended to limit the scope of the present invention by the following production examples, examples and experimental examples.

≪ Preparation Example 1 > Preparation of capsules

The outer film of the capsule was prepared as a water phase with the composition shown in Table 1, and the inner material was prepared with the composition shown in Table 2 as an oil phase. The sum of the components contained in the outer film of the capsule and the sum of the components contained in the inner material were each 100 parts by weight. The values in Tables 1 and 2 are based on parts by weight.

Raw material name Example Comparative Example One 2 One 2 Purified water Balance Balance Balance Balance Red ginseng condensate 35.0 35.0 35.0 35.0 Red ginseng moisturizer 2.0 2.0 2.0 2.0 Sodium polyacrylate 0.3 0.6 - - Hyaluronic acid - - - 0.6 Xanthan gum - - 0.6 - antiseptic Suitable amount Suitable amount Suitable amount Suitable amount Baby 1.0 1.0 1.0 1.0

Raw material name Example Comparative Example One 2 One 2 MCT oil Balance Balance Balance Balance Red ginseng oil 20 20 20 20 Evening Primrose Oil 20 20 20 20 Camellia oil 20 20 20 20 Spices Suitable amount Suitable amount Suitable amount Suitable amount antiseptic Suitable amount Suitable amount Suitable amount Suitable amount

The capsules were manufactured using the capsule manufacturing apparatus disclosed in Korean Patent Laid-Open Publication No. 2016-0116827. In the above patent application, fragrance is disclosed as a core contained in a capsule, and a film material is disclosed as a capsule film. In the present invention, the components of Tables 1 and 2 are used. In the above patent application, capsules were prepared by using a capsule manufacturing apparatus equipped with nozzles, dried and further cured to prepare hard capsules. In the present invention, soft capsules were prepared by excluding the drying step and the additional curing step. The prepared soft capsules were suitable for application to cosmetics because hard capsules had a hard outer membrane to be applied to cosmetics and a smooth outer membrane.

The sizes of the prepared capsules were measured using a microscope (Olympus SZ Luna) and ToupView (version x86) program, and the sizes of the capsules of Examples 1 and 2 were 4.1 mm (Fig. 1). The capsules of Comparative Examples 1 and 2 were similar in size to the capsules of Examples 1 and 2.

<Experimental Example 1> Capability of spreading and sensory evaluation

10 persons were evaluated for appearance, spreadability, and absorbency after pouring the formulations on the 5-point scale shown in Table 3 below. The evaluation results are shown in Table 4 (average value of evaluation results of 10 persons to be tested).

5 point scale 5 points 4 points 3 points 2 points 1 point Appearance after pumping formulation Very smooth lubricity usually Rug Very rugged Brittle Very good good usually Poor Very bad Absorbency Very good good usually Poor Very bad

Capsule type Explanation Formulation appearance Brittle Absorbency Example 1 Sodium Polyacrylate Prescription Capsule 4.6 4.8 4.2 Example 2 Sodium Polyacrylate Prescription Capsule 4.8 4.8 4.3 Comparative Example 1 Xanthan gum prescription capsule One One 1.1 Comparative Example 2 Hyaluronic acid prescription capsule 2.4 3 2.8

As a result of the evaluation, the other conditions were the same as in Examples 1 and 2, and when sodium polyacrylate was prescribed, the appearance was smooth after pouring the formulation (see FIG. 3) . However, in the case of Comparative Examples 1 and 2 in which a substance other than sodium polyacrylate was formulated, the appearance was not smooth after pouring the formulation, so that the visual effect was reduced, and the spreadability and the absorbency were remarkably decreased. In addition, in the case of the capsule of Comparative Example 2, granules were touched at the time of applying the skin, and it was confirmed that the capsule was absorbed after rubbing the skin for a long time after pumping. As shown in the results of Production Example 1, the capsules of Examples and Comparative Examples were similar in size and appearance, but it was found that the capsules of the Examples were smoother than those of the capsules of the Comparative Examples with the addition of sodium polyacrylate.

Each of the capsules prepared in Examples 1 and 2 and Comparative Examples 1 and 2 was filled in a container as shown in FIG. 2, and then the degree of spreading was visually observed by pumping. In the case of the capsules prepared in Examples 1 and 2 as well as the results confirmed by the sensory evaluation, the capsule was finely crushed and discharged at the time of pumping on the glass (see Fig. 3). When the capsule was spread on the glass, It was confirmed that there is almost no water (see Fig. 4). On the other hand, in the case of the capsules prepared in Comparative Examples 1 and 2, when the pellets were pumped and discharged, the shape of the crushed gel was easily observed with the naked eye, and the pellets remained in the form of pellets remaining on the glass, Reference).

These results show that, unlike the materials of the capsule membranes of Comparative Examples 1 and 2 which have been conventionally used, by prescribing sodium polyacrylate, it is possible to preserve the function of the contents in the form of a capsule while having a visual effect, The same feeling of feeling was complemented.

&Lt; Comparative Example 3 > Confirmation of stability of internal substance

It was confirmed that red ginseng oil contained in the capsules of Examples 1 and 2 was stable even after storage at high temperature for a long period of time. Non-encapsulated red ginseng oil was used as a control. The capsules of Examples 1 and 2 and the control red ginseng oil were each stored at 50 ° C for 8 weeks to observe the color and flavor of red ginseng oil. Observation results are shown in Table 5 below.

lapse Item Example 1 Example 2 Control group 1 week
color Good (no change) Good (no change) Good (no change) Flavor Good (no change) Good (no change) Good (no change) 2 weeks
color Good (no change) Good (no change) Good (no change) Flavor Good (no change) Good (no change) Good (no change) 3 weeks
color Good (no change) Good (no change) Good (no change) Flavor Good (no change) Good (no change) Good (no change) 4 weeks
color Good (no change) Good (no change) Good (no change) Flavor Good (no change) Good (no change) Has oiled 8 weeks
color Good (no change) Good (no change) Good (no change) Flavor Good (no change) Good (no change) Has oiled

As a result, the red ginseng oil in the capsules of Examples 1 and 2 was blocked with oxygen by the outer membrane of the capsule, so that it was stable without change in color or flavor of the red ginseng oil contained in the capsules even at the 8th week of storage. On the other hand, the non - encapsulated red ginseng oil as a control group changed its flavor from red ginseng oil for 4 weeks.

From these results, it was found that by using the capsules of the present invention, components contained as an internal substance can be protected. Therefore, the capsule structure of the present invention can be usefully used in the field of cosmetics.

Claims (7)

An inner substance comprising a cosmetic active ingredient; And
An outer film comprising sodium polyacrylate and agar,
Wherein the sodium polyacrylate and the agar are contained in a proportion of 0.01 to 10 parts by weight and 0.1 to 10 parts by weight, respectively. The method according to claim 1,
Wherein the outer membrane further comprises hyaluronic acid. delete The method according to claim 1,
Wherein the internal material comprises at least one selected from the group consisting of a lipophilic component, a W / O formulation, and a W / S formulation. The method of claim 4,
Wherein the internal material is at least one of vegetable derived oils and W / O formulations. The method according to claim 1,
Wherein the capsule has a size of 1 mm to 8 mm. A cosmetic composition comprising the capsule of claim 1.

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