KR101652034B1

KR101652034B1 - Portable full-automatic centrifuge and sampler

Info

Publication number: KR101652034B1
Application number: KR1020090136065A
Authority: KR
Inventors: 김성욱
Original assignee: 김성욱
Priority date: 2009-12-31
Filing date: 2009-12-31
Publication date: 2016-09-09
Also published as: KR20110079100A

Abstract

A centrifugal separator (100) for separating components of a sample by rotating a sample tube (10) having a liquid sample at a high speed by a rotor. A sample detector 600 for sensing the spectral difference of the centrifuged sample by the centrifugal separator 100 and recognizing the boundaries of the respective components; A sample extractor 200 for extracting a specific component of a sample classified by the boundary recognized by the sample detector 600 into a sample extracting container 20 provided separately; A centrifuge moving rail 300 for guiding the centrifuge 100 to reciprocate along a designated path; A sample extractor moving rail 400 for guiding the sample extractor 200 to reciprocate along a designated path; The centrifuge separator 100 and the sample extractor 200 are accommodated in the centrifuge 100 and the sample extractor 200 is exposed to the outside through the centrifuge moving rail 300 and the sample extractor 200, A door 520 and 530 provided adjacent to one end of the movable rail 400 and an operation button 550 corresponding to an input terminal for adjusting the operation state of the centrifuge 100 and the sample extractor 200, A case 500 provided with the case 500; An extractor movement controller for controlling the sample extractor 200 to move and stop the sample extractor 200 to a position of the sample tube 10 belonging to a specific region among a plurality of regions classified by the boundary recognized by the sample detector 600; And an operation state of the centrifugal separator 100 and the sample extractor 200 is adjusted to a stop or an operation state according to a signal inputted through the operation button 500 of the case or to a designated position of the centrifugal separator 100 And a controller for controlling the movement and rotation of the sample extractor 200 and the operation of the sample extractor 200 and the movement of the sample extractor 200 to a designated position automatically and continuously. And more particularly, to a portable automatic centrifugal separator and a sample extracting device which can be automatically carried out in a single case and can be easily moved, installed and used by realizing miniaturization.

Pre-automatic, centrifuge, sample extraction, carry, sample, case

Description

[0001] Portable full-automatic centrifuge and sampler [0002]

The present invention relates to a fully automatic centrifugal separator and a sample extracting apparatus which are easy to carry, and more particularly to an automatic centrifugal separator and a sample extracting apparatus which can easily carry out a work for extracting a specific component of a liquid sample, And more particularly, to a fully automatic centrifugal separator and a sample extracting device.

In general, centrifugation is a method of separating heavy and light parts from a solution, mixture or suspension by centrifugal force. Centrifugation is a method of mixing And is widely used in various fields such as disease medicine, geology, biological environment, food nutrition, life sciences, etc. Experimental and industrial widely .

After separating the components of the liquid sample using the centrifugal separator, it is generally accompanied by an operation of collecting only a specific component separated and formed at a specific position of the sample tube. The operation of directly inserting the needle at a specific position on the sample tube Particular attention should be paid to rapid and accurate quantitative sampling of specific components prior to relaxation of sample separation.

Even if the components of the liquid sample are stably separated using a centrifugal separator, in order to collect the specific components of the separated samples and actually use them, it is difficult to waste the expensive sample, lower the reliability of the obtained sample components, In order to minimize accidents such as loss of sample, centrifuges are also not widely used in practically applicable fields due to the difficulty of the sampler's skill.

In order to secure a sufficient rotational locus sufficient for centrifugal separation of a sample, the conventional centrifugal separator must be installed separately from other devices so as not to overlap with each other. Therefore, It is difficult to realize a complex function other than a simple combined structure in which a mutually spaced apart structure is installed. Therefore, the design is made in a large size, and the result is moved to a necessary place, There is a problem in that it is difficult to do.

Disclosure of Invention Technical Problem [8] The present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a bio- And to provide a fully automatic centrifugal separator and a sample extracting device which are easy to carry.

In order to accomplish the above object, the present invention provides a centrifuge comprising: a centrifuge (100) for rotating a sample tube (10) in which a liquid sample is stored at a high speed by a rotor to separate components of the sample; A sample detector 600 (not shown) for detecting a spectroscopic difference of a sample centrifuged by the centrifuge 100 and recognizing an interface between the components; A sample extractor 200 for quantitatively extracting a specific component of the sample identified by the interface recognized by the sample detector 600 into a specimen collection container 20 provided separately; A centrifuge moving rail 300 for guiding the centrifuge 100 to reciprocate along a designated path; A sample extractor moving rail 400 for guiding the sample extractor 200 to reciprocate along a designated path; The centrifuge separator 100 and the sample extractor 200 are accommodated in the centrifuge 100 and the sample extractor 200 is exposed to the outside through the centrifuge moving rail 300 and the sample extractor 200, A door 520 and 530 provided adjacent to one end of the movable rail 400 and an operation button 550 corresponding to an input terminal for adjusting the operation state of the centrifuge 100 and the sample extractor 200, A case 500 provided with the case 500; An extractor movement controller for controlling the sample extractor 200 to move and stop the sample extractor 200 to a position of the sample tube 10 belonging to a specific region among a plurality of regions classified by the boundary recognized by the sample detector 600; And an operation state of the centrifugal separator 100 and the sample extractor 200 is adjusted to a stop or an operation state according to a signal inputted through the operation button 500 of the case or to a designated position of the centrifugal separator 100 And a controller (not shown) for controlling the movement and rotation of the sample extractor 200, the operation of the sample extractor 200, and the movement of the sample extractor 200 to a designated position automatically and continuously, The extracting device is a technical point.

Here, it is preferable that the sample tube 10 has a concave shape with a cross-sectional size narrower at the center than the upper and lower portions.

The sample tube 10 preferably has the same cross-sectional size as the upper, middle, and lower sections.

The point where the sample tube 10 and the sample detector 600 are connected and the point where the sample tube 10 and the sample extractor 200 are connected are classified according to the surface position of the sample tube 10 A sample tube fixing means (not shown) for restraining the sample tube 10 in the forward and backward directions on the centrifuge 100 so as to be kept constant during the operation of the sample detector 600 and the sample extractor 200, ). &Lt; / RTI >

The sample tube securing means includes concavities and convexities formed on the surface of the sample tube 10 by being depressed or protruded; And concavo-convex coupling means formed on a connection portion of the centrifuge (100) with the sample tube (10) at a position corresponding to the concavities and convexities corresponding to the concavities and convexities.

The sample tube fixing means includes a metal member attached to the surface of the sample tube 10; And a magnetic member formed at a position corresponding to the magnetic member at a connection portion of the centrifuge (100) with the sample tube (10).

The centrifugal separator 100 is provided with a tube movement control unit which moves the sample tube 10 to a specified position inside the case 500 for the purpose of recognizing, And a controller.

In addition, the sample detector 600 may detect spectroscopic difference using a light beam of a specific wavelength, or may detect a difference of a centrifuged sample using an image analyzer such as a CCD image analyzer, And the like.

The sample extracting vessel (20) includes a cylinder part (21); A piston portion 22 which is reciprocated by operation of a container operating portion of the sample extractor and adjusts the expansion and contraction of the volume of the cylinder portion 21; And the sample extraction container 20 is opened and protruded from the distal end of the cylinder 21 and is engaged with the tube penetration part 230 of the sample extractor and a separate injection needle is mounted outside the case 500, And a needle coupling part 23 for allowing the needle coupling part 23 to be used as a syringe.

In addition, the sample extractor 200 includes a cassette unit 210 to which a plurality of sample extraction vessels 20 are attached and continuously supply the sampled samples to one side; A container transfer unit 220 for transferring the sample extraction container 20 supplied to the designated position to the sample tube 10 side mounted on the centrifuge 100 and returning the sample extraction container 20 back to its original position; A needle-shaped tube penetratingly connected to the open end of the sample extraction container 20 supplied to the container transfer part 220 and moved together with the container transfer part 220 to penetrate the sample tube 10, (230); And a vessel manipulating unit for manipulating the size and pressure of the sample extracting vessel 20 to extract the sample in the sample tube 10 into the sample extracting vessel 20 mounted on the vessel transferring unit 220 (Not shown).

It is also preferable that the sample extractor 200 is provided in the case 500.

The cassette unit 210 of the sample extractor includes a container mounting table 211 having a supporting surface for continuously mounting and transporting the plurality of sample extraction containers 20; An elastic spring (not shown) installed to elastically press the plurality of sample extraction containers 20 mounted on the container mounting table 211 to one side; A catching jaw 213 formed at an open end of the container mounting table 211 for restraining the sample extracting container 20 moved to one side end of the container mounting table 211 by the elastic spring at a predetermined position; And the sample extraction container 20 in a state where the sample is extracted and accommodated is moved from the container transfer unit 220 of the sample extractor to the other side of the container mount 211 or another transfer space side by gravity, And a container conveying passage 214 continuously formed at the lower end of the open end of the mounting table 211.

The sample extractor 200 is connected to the cassette 210 of the sample extractor through a door 530 of the case 500 at a position accessible to the inside and outside of the case 500, An external supply transfer path 241 having an inclined surface capable of downwardly transferring the sample extracting container 20 of the sample extracting container 20 to a designated position and the sample extracting container 20 transferred on an inclined surface of the external supply transfer path 241 And a tray unit 240 having a container holder 242 supported in a stationary state at a designated position.

The external supply transfer path 241 of the tray of the sample extractor is connected to the sample extraction container 20 so that one side of the sample extraction container 20 is finally transferred from the case 500, And the container tray 242 of the tray part of the sample extractor has a lateral angle corresponding to the lower end of the external supply conveyance path 241 And it is preferably recessed in a shape corresponding to the lower outer surface of the sample extraction container 20.

The sample extractor 200 includes a main rail connection port 251 that is connected to and guided by the sample extractor transfer rail 400 and is reciprocated and an auxiliary rail 251 that is formed in a rail structure on the main rail connection port 251, And an auxiliary rail connection port 253 integrally connected to the cassette 210 of the sample extractor and connected to and guided by the auxiliary rail 252 to reciprocate the cassette 210 (250) for moving the sample extractor (200) along a guide path in which the sample extractor transfer rail (400) and the auxiliary rail (252) are continuously formed.

According to the present invention, there is provided a centrifugal separator for centrifuging a sample and a sample extractor for automatically extracting a specific component of the centrifuged sample in a case having a predetermined volume, It is possible to perform the separation of components of the liquid sample and the extraction process of the separated and formed components automatically in one case by providing the controller capable of continuously and automatically performing the operation of the sample extractor and the movement to the designated position.

In addition, since the space for performing the centrifugal separation and the sample extraction of the sample and the space for mounting and acquiring the sample are separately formed in the case and the outside, respectively, the case is formed by connecting the centrifugal separator and the sample extractor, There is another effect that the device can be downsized by an efficient spatial division structure depending on the operation intervention of the user because it has only the minimum volume required for performing the extraction.

The operation and movement of the centrifugal separator and the sample extractor are sequentially performed along the designated sequence and route in the case, and the case is stably intercepted so that the user's operation can not be arbitrarily interrupted during the operation of the centrifugal separator and the sample extractor Thereby, there is another effect that the space and copper line required to perform the functions of the centrifugal separator and the sample extractor can be stably secured and maintained in the case without overlapping with the copper wire of the user.

In addition, a process in which the centrifuge and the sample extractor are automatically moved along the designated copper line by operating the operation buttons of the case after the user attaches the sample tube and the sample extraction container to the centrifugal separator and the sample extractor, respectively, The entire process corresponding to the process of centrifugal separation and extraction of a specific sample and the process of feeding the extracted sample to the outside of the case can be automatically implemented, so that there is another effect that anyone can easily use the process by simple button operation.

In addition, since the separation of the components of the liquid sample is performed stably using a centrifugal separator, and the sample collector can quickly and accurately quantitatively collect only specific components before diluting the separation state of the components of the sample, There is another effect that anyone can easily use it without worrying about the waste of expensive sample, the reliability of the obtained sample component, and the loss of the sample which is difficult to re-acquire.

Also, since it can be used by simple button operation regardless of skill, centrifugal separator can be practically applied throughout the applicable field of principle of centrifugation, and by the space efficient installation structure of centrifuge and sample extractor It is possible to easily obtain the separation result of the sample on the site and to apply it to the site easily.

The present invention having the above-described structure will be described in more detail with reference to the following drawings.

FIG. 1 is a perspective view showing a first embodiment of a fully automatic centrifugal separator and sample extracting apparatus according to the present invention, and FIGS. 2, 3 and 4 each are a perspective view and a perspective view, respectively, FIG. 5 is a perspective view showing a state in which the centrifuge is transferred to the outside of the case, and FIG. 6 is a perspective view showing a state in which the sample extractor is transferred to the outside of the case.

1 to 4, the centrifugal separator 100, the sample detector 600 (not shown), the sample extractor 200, the centrifugal separator 100, A centrifuge separator 200 and a sample extractor 200 are disposed in the case 500. The sample extractor 200 is connected to the centrifuge 100 and the sample extractor 200. The sample extractor 200 includes a centrifuge moving rail 300, a sample extractor moving rail 400, a case 500, and a controller (not shown) And the sample extractor 200 are installed to be movable along the centrifuge moving rail 300 and the sample extractor moving rail 400. The controller controls the operations of the centrifuge 100 and the sample extractor 200 It has this automatically controlled operating structure.

The centrifuge 100 is equipped with a sample tube 10 containing a bio sample such as blood and is rotated at a specified speed and time by a rotor at a high speed so that the components of the sample contained in the sample tube 10 The present invention is not limited to a specific structure as long as it can be accommodated in the case 500 and can be movably installed on the centrifuge moving rail 300.

The structure and operation principle of the centrifugal separator 100 are well known in the art and will not be described in detail. A centrifugal separator having an appropriate structure may be selectively applied according to the application field of the present invention, And a tube movement controller (not shown) for controlling the movement and stop of the sample tube 10 to a designated position inside the case 500 for recognition, detection, or sample extraction of each centrifuged component And the like.

The sample detector 600 detects the spectral difference of the centrifuged sample by the centrifugal separator 100 and recognizes the interface between the centrifugal separator 100 and the centrifugal separator 100, Like the centrifugal separator 100, the centrifugal separator 100 is well known in the art except for a difference in the installation structure inside the case 500. The basic operation principle and the basic structure for implementing the same are not described in detail. .

In detecting the spectroscopic difference of the sample by the sample detector 600 and recognizing the interface between the components, spectroscopic difference may be detected using light of a specific wavelength, or an image analyzer such as a CCD image analyzer may be used And detecting the difference of the centrifuged samples so as to recognize the boundary surfaces of the respective components, it is preferable to selectively apply the sample detector of a suitable structure according to the application field, the use place, etc. of the present invention.

The sample extractor 200 extracts a specific component of a sample subjected to component separation in the centrifuge 100 from the sample tube 10 into the sample extracting container 20 as a separate container, The sample extracting container 20 mounted on the cassette unit 210 includes a cassette unit 210, a container transfer unit 220, a tube penetration unit 230 and a container operation unit (not shown) The tube penetration part 230 moves together with the vessel 220 and the sample extraction vessel 20 and penetrates the sample tube 10 when the vessel 220 is moved toward the centrifuge 100, The volume of the inner space of the sample extraction container 20 is adjusted by adjusting the volume of the inner space of the sample extraction container 20 or increasing or decreasing the pressure of the sample tube 10 in a state where the tube penetration part 230 penetrates the sample tube 10, To the inside of the sample extraction container (20).

The cassette unit 210 is a component for mounting a plurality of sample extraction vessels 20 and continuously supplying the vessels to one side where the vessels 220 are installed. The cassette unit 210 includes a container mount 211, an elastic spring (not shown) And the sample extracting container 20 mounted on the container mounting table 211 is continuously elastically deformed by the elastic spring toward the conveying unit 220 side, The container is released from the cassette unit 210 and is released from the cassette unit 210. When the sample is extracted, the container is detached from the cassette 200, The transfer to another space is performed.

The container mounting table 211 provides a support surface for continuously mounting and transporting the plurality of sample extraction containers 20, and the elastic spring is mounted on the container mounting table 211, (211) which is moved to one side of the container mounting table (211) by the elastic spring (213) is provided on the other side of the container mounting table (211) And is protruded from the open end of the container mount 211 to restrain the container 20 in place.

The sample transporting passage 214 separates the sample extracting container 20 from the sample transporting unit 220 of the sample extracting unit and transports the sample to the container mounting table 211 by a conveying device such as a conveyor. Or is continuously formed below the open end of the container mount 211 so as to be movable by gravity on the transport space side separately provided.

The container transferring unit 220 transfers the sample extracting container 20 supplied to the designated position on the cassette unit 210 to the sample tube 10 mounted on the centrifuge 100 and returns it to the home position. (Not shown) that is connected to or coupled to the surface of the sample extraction container 20 so as to be able to perform the transfer, a cylinder (not shown) that provides a pressing force capable of reciprocating the container connection port at a designated distance, And a reciprocating conveying member such as a motor (not shown) and a rail (not shown).

The tube penetration part 230 is formed in the centrifuge 100 of the container transfer part 220 so as to penetrate the sample tube 10 while the container is moved to the sample tube 10 side together with the transfer part 220. The sample extracting vessel 20 is connected to the vessel 220 and connected to the open end of the sample extracting vessel 20 through which the sample is discharged. Is provided at a position corresponding to the open end of the sample extraction container (20) so that a flow path is simultaneously formed.

The vessel manipulating unit (not shown) is configured to inject a sample in the sample tube 10 into the sample extracting vessel 20 so as to provide a pressing force capable of flowing into the sample extracting vessel 20 mounted on the vessel conveying unit 220, The sample extracting vessel 20 is a component for manipulating the size and pressure of the sample extracting vessel 20. The sample extracting vessel 20 is configured to draw air in the sample extracting vessel 20 to reduce the pressure, (22) for adjusting the volume of the cylinder part (21) by reciprocating movement of the piston part (22) with respect to the open end of the sample extraction container (20) And the pressing force required for the flow of the sample to the sample-extracting vessel 20 is provided in various ways including an embodiment in which the sample is flowed by reducing the pressure by expanding the space by moving in the opposite direction There.

The sample extractor 200 is provided with a plurality of vessels 220, a plurality of tube penetrations 230 and a vessel manipulation unit, or a plurality of sample extractors 200, It is also preferable that a plurality of samples can be concurrently or independently performed.

The sample tube 10 may have a general shape having the same cross-sectional size as the upper, middle, and lower sections. However, if a specific component of the sample to be extracted by the sample extractor 200 is centrifuged in the sample tube 10 When the sample tube 10 is formed so as to have a concave shape having a cross sectional size narrower than the upper and lower portions of the sample tube 10, The extraction of a specific component of the sample using the sample extractor 200 can be more clearly and stably performed because the specific component of the sample to be extracted forms a more expanded thickness and surface area.

The sample tube 10 used in the present invention can be subjected to spectroscopic analysis along the longitudinal direction of the sample tube 10 so that the point of connection of the sample detector 600 and the penetration of the needle material can be made without damage The connection between the sample tube 10 and the sample detector 600 and the sample extractor 200 is maintained at a suitable position and the sample detector 10 is connected to the sample extractor 200, (Not shown) for restraining the sample tube 10 in the forward and backward directions on the centrifuge 100 so that the connection state is clearly maintained even during the operation of the sample extractor 600 and the sample extractor 200, .

The sample tube fixing means includes protrusions and depressions (not shown) which are formed on the surface of the sample tube 10 so as to be depressed or projected from the surface of the sample tube 10 and a position corresponding to the irregularities on the connection portion of the centrifuge 100 with the sample tube 10 (Not shown) formed on the surface of the sample tube 10 or a metal member attached to the surface of the sample tube 10 and a connection portion between the metal tube and the sample tube 10 of the centrifuge 100, And a magnetic member formed on a position corresponding to the magnetic member on the centrifugal separator 100. If the sample tube 10 can be restrained in the forward and backward directions on the centrifuge 100, .

When the sample extracting vessel 20 has a structure including the cylinder 21 and the piston 22 in forming the open end to be engaged with the tube penetration 230 of the sample extractor, When a needle coupling part 23 having a structure in which a separate injection needle can be mounted on the distal end of the cylinder part 21 is formed so as to be opened and protruded, The sample extracting container 20 can be used as an ampoule or as a syringe with a separate injection needle mounted thereon.

The centrifuge moving rails 300 and the sample extractor moving rails 400 are connected to the centrifuge moving roils 300 and the sample extractor moving rails 400 through the centrifugal separator 100 and the sample extractor 200, The sample extractor 200, the centrifuge moving rail 300, and the sample extractor moving rail 400 are accommodated in the case 500 so as to be capable of reciprocating along a designated path of the centrifugal separator 100, And an internal space portion of a constant volume that can be installed, and forms an appearance of a fully portable centrifugal separator and sample extracting apparatus according to the present invention.

The case 500 may be provided with a lid 510 capable of opening and closing the inner space so that the centrifugal separator 100 and the sample extractor 200 can be easily checked and repaired. 100 and the sample extractor 200 are exposed to the outside through the centrifuge separator door 520 and the sample extractor moving rail 400 at positions adjacent to the one end of the centrifuge moving rail 300 and the sample extractor moving rail 400, A door 530 is provided and an operation button 550 corresponding to an input terminal for adjusting the operation state of the centrifuge 100 and the sample extractor 200 is provided.

The controller (not shown) receives a signal through the operation button 500 of the case, and stops the operation of the centrifuge 100 and the sample extractor 200 according to a program or an electronic circuit structure inputted thereto The operation of the sample extractor 200 and the movement of the sample extractor 200 to the designated position are successively carried out or the centrifugal separator 100 is moved and rotated to the designated position, .

The sample extracting container 20 in a state in which the sample is extracted and accommodated is designated at one end of the cassette 210 of the sample extractor through which the sample 500 enters and leaves the inside and outside of the case 500 through the door 530 of the case (241) having an inclined surface that can be moved downward to a position where the sample supply container (20) is transported, and the sample extracting container (20) conveyed along an inclined surface of the external supply conveyance path (241) The tray extractor door 530 may be connected to the tray 240 without having to be formed in a size corresponding to the entire cassette 210 of the sample extractor. The sample extracting unit 200 may be formed in a small size corresponding to the size of the sample extractor 200. The sample extractor 200 may be formed in a small size such that the entirety of the cassette 210 of the sample extractor is not exposed to the outside, sample Wherein the output container 20 case 500 can be supplied from the outside.

When the user performs an operation of releasing or grasping and lifting the sample extracting container 20 held in the container holder 242 of the tray part, the both ends in the longitudinal direction of the sample extracting machine 20 are pressed Or in a state in which the thumb is lightly brought into close contact with the upper surface of the sample extraction container 20 in comparison with the operation of pushing the sample extraction container 20 in the vertical direction or in the horizontal direction in which the palm is located above the sample extraction container 20 The sample extraction container 20 can be more stably moved toward the user's finger or palm side by the pushing or pulling operation in the horizontal direction in which the remaining finger or palm is positioned below the sample extraction container 20. [

Therefore, the external supply path 241 of the tray part of the sample extractor is connected to the sample extraction container 20 so that one side of the sample extraction container 20 is finally transferred from the case 500, And the container tray 242 of the tray part of the sample extractor has a lateral angle corresponding to the lower end of the external supply conveyance path 241, It is preferable that the sample extraction container 20 is formed with a depression corresponding to the lower outer surface of the sample extraction container 20.

A main rail connection port 251 connected to and guided by the sample extractor transfer rail 400 to be reciprocated; an auxiliary rail 252 formed in a rail structure on the main rail connection port 251; Which is integrally connected to the cassette 210 of the sample extractor 200 and has an auxiliary rail connection port 253 which is connected to and guided by the auxiliary rail 252 and is reciprocated, The cassette 210 of the sample extractor can be moved along the guide path in which the sample extractor transfer rail 400 and the auxiliary rail 252 are continuously formed, It is possible to further extend the travel distance of the sample extractor 200 and to achieve the same effect by providing the same structure as that of the multiple transfer unit 250 below the centrifugal separator 100.

The portable automatic centrifugal separator and sample extracting apparatus according to the present invention includes the centrifugal separator 100 for centrifuging a sample and the sample extractor 200 for automatically extracting specific components of a centrifuged sample Is provided inside the case 500 having a predetermined volume and the controller capable of continuously and automatically performing the operation of the centrifuge 100 and the sample extractor 200 and the movement to the designated position, And the extraction process of the separated and formed specific components can be performed automatically in one case.

The case 500 is separated from the centrifugal separator 100 and the case 500 in such a manner that a space for performing centrifugal separation and sample extraction of the sample and a space for mounting and acquiring the sample are separately formed inside and outside the case 500, Since the sample extractor 200 has only a minimum volume required to perform centrifugal separation and sample extraction in cooperation with each other, it is possible to realize miniaturization of the apparatus by an efficient spatial division structure according to the operation intervention of the user.

The operation and movement of the centrifugal separator 100 and the sample extractor 200 are sequentially performed in the case 500 in the designated order and path by the controller and the case 500 is connected to the centrifugal separator 100 and the sample extractor 200 so that the space and the copper line required to perform the functions of the centrifuge 100 and the sample extractor 200 can be controlled by the user And can be stably secured and held in the case 500 without overlapping with the copper wire of the case 500. [

After the user attaches the sample tube 10 and the sample extraction container 20 to the centrifugal separator 100 and the sample extractor 200 and then operates the operation button 550 of the case, The centrifugal separator 100 and the sample extractor 200 are automatically moved along a designated copper line; a step of centrifuging the sample and extracting a specific sample; 20) can be automatically implemented, so that it can be easily used by anyone with a simple button operation.

In addition, since the separation of the components of the liquid sample is performed stably using the centrifugal separator 100, the sample collector 200 can quickly and precisely collect a predetermined amount of the component before the component separation state of the sample is diluted Can be easily used by anyone without worrying about waste of high-priced sample, loss of reliability of the obtained sample component and loss of sample which is difficult to re-acquire.

The centrifugal separator 100 and the sample extractor 200 can be applied to the centrifugal separator 100 and the sample extractor 200, ), It is possible to easily obtain the separation result of the sample on the site and apply it.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, It is to be understood that the techniques which can be used by those skilled in the art to which the present invention belongs are included in the technical scope of the present invention.

1 is a perspective view showing a first embodiment of a fully automatic centrifugal separator and sample extracting apparatus according to the present invention,

Fig. 2 - Fig. 1 Fig. 2 - Fig.

Figure 3 - Front view of the lumbar region of Figure 1

Figures 4 - Figure 1 -

5 is a perspective view showing a state where the centrifuge is transferred to the outside of the case;

6 is a perspective view showing a state in which the sample extractor is transferred to the outside of the case;

DESCRIPTION OF THE REFERENCE SYMBOLS USED IN THE DRAWINGS

10: sample tube 20: sample extraction container

21: cylinder part 22: piston part

23: Needle coupling part 100: Centrifuge

200: sample extractor 210: cassette part

211: container mounting base 213:

214: Container transfer path 220: Container transferring

230: tube penetration part 240:

241: External feed path 242: Casing stand

250: multiple transmission 251: main rail connection port

252: auxiliary rail 253: auxiliary rail connection port

300: Centrifuge moving rail 400: Sample extractor moving rail

500: Case 510: Cover

520: centrifuge door 530: sample extractor door

550: Operation button 600: Sample detector

Claims

A centrifugal separator (100) for separating the components of the sample by rotating the sample tube (10) containing the liquid sample at a high speed by a rotor;

A sample detector 600 for sensing the spectral difference of the centrifuged sample by the centrifugal separator 100 and recognizing the boundaries of the respective components;

A sample extractor 200 for extracting a specific component of a sample classified by the boundary recognized by the sample detector 600 into a sample extracting container 20 provided separately;

A centrifuge moving rail 300 for guiding the centrifuge 100 to reciprocate along a designated path;

A sample extractor moving rail 400 for guiding the sample extractor 200 to reciprocate along a designated path;

The centrifuge separator 100 and the sample extractor 200 are accommodated in the centrifuge 100 and the sample extractor 200 is exposed to the outside through the centrifuge moving rail 300 and the sample extractor 200, A door 520 and 530 provided adjacent to one end of the movable rail 400 and an operation button 550 corresponding to an input terminal for adjusting the operation state of the centrifuge 100 and the sample extractor 200, A case 500 provided with the case 500;

An extractor movement controller for controlling the sample extractor 200 to move and stop the sample extractor 200 to a position of the sample tube 10 belonging to a specific region among a plurality of regions classified by the boundary recognized by the sample detector 600; And

The centrifugal separator 100 controls to separate the sample stored in the sample tube 10 according to a signal inputted through the operation button 550 of the case, A controller for controlling the moving rail 400 to reciprocally move along a designated path to extract a specific component of the sample separated from the sample tube 10 in consideration of the boundary surface of each component recognized by the sample detector 600, ;

Lt; / RTI >

The controller controls the centrifugal separator 100 and the sample extractor 200 so that the component separation of the sample by the centrifuge 100 and the extraction of a specific component of the sample separated by the sample extractor 200 are continuously performed. And a control unit for controlling the operation of the centrifugal separator.

The apparatus of claim 1, wherein the sample tube (10)

The centrifugal separator according to any one of claims 1 to 4, wherein the center portion of the sample has a concave shape having a narrow cross-sectional size as compared with the upper and lower portions.

The apparatus of claim 1, wherein the sample tube (10)

Wherein the cross-sectional size of the upper, middle, and lower portions is the same.

The method according to claim 1,

A point where the sample tube 10 and the sample detector 600 are connected and a point where the sample tube 10 and the sample extractor 200 are connected are classified according to the surface position of the sample tube 10, A sample tube fixing means for restraining the sample tube 10 in the forward and backward directions on the centrifuge 100 such that the sample tube 10 is kept constant during operation of the detector 600 and the sample extractor 200;

Wherein the first and second centrifugal separators are connected to each other.

The apparatus according to claim 4,

Irregularities formed on the surface of the sample tube 10 by being depressed or protruded; And

Concavo-convex coupling means formed in a shape corresponding to the concavities and convexities at positions corresponding to the concavities and convexities on a connection portion of the centrifuge 100 with the sample tube 10;

The apparatus according to claim 4,

A metal member attached to a surface of the sample tube 10; And

A magnetic member formed at a position corresponding to the metal member at a connection portion of the centrifuge 100 with the sample tube 10;

And an automatic centrifugal separator and a sample extracting device.

The centrifugal separator according to claim 1, wherein the centrifugal separator (100)

A tube movement controller for controlling movement of the sample tube (10) to a specified position inside the case (500) for recognition, detection, or sample extraction of each centrifuged component;

And an automatic centrifugal separator and a sample extracting device.

The apparatus of claim 1, wherein the sample detector (600)

Characterized in that the method comprises the steps of scanning the spectroscopic difference using a light beam of a specific wavelength or detecting the difference of centrifuged samples by using a CCD image analyzer to recognize the interface between the components, Separation and sample extraction device.

The apparatus according to claim 1, wherein the sample extracting vessel (20)

A cylinder portion 21;

A piston portion 22 which is reciprocated by operation of a container operating portion of the sample extractor and adjusts the expansion and contraction of the volume of the cylinder portion 21; And

The sample extraction container 20 is opened and protruded from the distal end of the cylinder 21 and is engaged with the tube penetration part 230 of the sample extractor and a separate injection needle is mounted outside the case 500, A needle coupling part (23) for making it usable as a syringe;

And an automatic centrifugal separator and a sample extracting device.

The apparatus of claim 1, wherein the sample extractor (200)

Wherein a plurality of sample vessels are provided inside the case.

The apparatus of claim 1, wherein the sample extractor (200)

A cassette part 210 to which a plurality of sample extraction containers 20 are attached and continuously supplied to one side;

A container transferring unit 220 for transferring the sample extraction container 20 supplied to the designated position to the sample tube 10 side mounted on the centrifuge 100 and returning the sample extraction container 20 back to its original position;

A needle-like tube penetration part (not shown) connected to the open end of the sample extraction container 20 supplied to the vessel 220 and moved together with the vessel 220 and penetrating the sample tube 10 230); And

A container operation unit for operating the size and pressure of the sample extraction container 20 so as to extract a sample inside the sample tube 10 into the sample extraction container 20 mounted on the container transfer unit 220;

And an automatic centrifugal separator and a sample extracting device.

12. The sample extractor of claim 11, wherein the cassette (210)

A container mounting table (211) having a support surface capable of continuously mounting and transporting the plurality of sample extraction containers (20);

An elastic spring installed to elastically press the plurality of sample extraction containers 20 mounted on the container mounting table 211 to one side;

A catching jaw 213 formed at an open end of the container mounting table 211 for restraining the sample extracting container 20 moved to one side end of the container mounting table 211 by the elastic spring at a predetermined position; And

The sample extracting container 20 in a state in which the sample is extracted and accommodated is moved from the container transferring unit 220 of the sample extracting device to the other side of the container mounting table 211 or another transferring space side by gravity A container conveyance path 214 formed continuously below the open end of the stand 211;

Wherein the sample is taken out of the sample container.

13. The method according to claim 11 or 12, wherein the sample extractor (200)

The sample extraction container 20 connected to the cassette 210 of the sample extractor at a position where the sample 500 can enter and exit the inside and outside of the case 500 through the door 530 of the case, (241) having an inclined surface capable of being downwardly conveyed to a position of the external supply conveyance path (241), and a sample collection container (20) supported on the inclined surface of the external supply conveyance path A tray part 240 provided with a container support 242;

And an automatic centrifugal separation and sample extraction device which is easy to carry.

14. The apparatus according to claim 13, wherein the external supply path (241) of the tray portion of the sample extractor

The one side of the sample extraction container 20 for supporting and transporting one side of the sample extraction container 20 so that the one side of the sample extraction container 20 is finally distant from the case 500 from the case 500, Lt; / RTI >

The container tray (242) of the tray portion of the sample extractor

And is formed in a shape corresponding to the lower outer surface of the sample extracting vessel (20) and is formed to be recessed and formed in a shape corresponding to the lower end of the external supply conveying path (241) Sample extraction device.

12. The apparatus of claim 11, wherein the sample extractor (200)

A main rail connection port 251 connected to and guided by the sample extractor moving rail 400 and reciprocating thereon, an auxiliary rail 252 formed in a rail structure on the main rail connection port 251, The cassette 210 of the sample extractor is connected to the sample extractor moving rail 400 through the auxiliary rail connection port 253 integrally connected to the auxiliary rail 210 and connected to the auxiliary rail 252 and guided and reciprocated. And the auxiliary rail (252) are continuously moved along the guide path;

Wherein the sample is taken out of the sample container.