KR101505445B1 - Composition comprising 5-aminolevulinic acid or ester thereof and natural extracts - Google Patents
Composition comprising 5-aminolevulinic acid or ester thereof and natural extracts Download PDFInfo
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- KR101505445B1 KR101505445B1 KR1020130073350A KR20130073350A KR101505445B1 KR 101505445 B1 KR101505445 B1 KR 101505445B1 KR 1020130073350 A KR1020130073350 A KR 1020130073350A KR 20130073350 A KR20130073350 A KR 20130073350A KR 101505445 B1 KR101505445 B1 KR 101505445B1
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- extract
- aminolevulinic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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Abstract
본 발명은 5-아미노레불린산, 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물; 은행추출물; 및 연잎추출물; 을 유효성분으로 포함하는 여드름 개선용 조성물에 관한 것으로, 5-아미노레불린산, 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물; 은행추출물; 및 연잎추출물; 을 유효성분으로 포함하는 조성물은 천연 원료를 사용함으로써 기존에 비해 현저한 여드름 개선, 기미·잡티의 개선, 민감성 피부 및 건성 피부 개선, 피부염, 피부질환 및 피부거침 개선을 위해 사용되는 것을 특징으로 하는 조성물이다.The present invention relates to a compound selected from 5-aminolevulinic acid, 5-aminolevulinic acid ester or a salt thereof; Bank extract; And lotus leaf extract; As an active ingredient, a compound selected from 5-aminolevulinic acid, 5-aminolevulinic acid ester or a salt thereof; Bank extract; And lotus leaf extract; Is used for the improvement of acne, improvement of stain and dullness, improvement of sensitive skin and dry skin, dermatitis, skin disease and improvement of roughness of skin as compared with the conventional ones by using natural raw materials to be.
Description
본 발명은 천연 원료를 사용함으로써, 안정적으로 여드름을 개선할 수 있는, 5-아미노레불린산, 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물; 은행추출물; 및 연잎추출물; 을 유효성분으로 포함하는 여드름 개선용 조성물, 기미·잡티의 개선용 조성물, 민감성 피부 및 건성 피부 개선용 조성물, 피부염, 피부질환, 피부거침 개선용 조성물에 관한 것이다.
The present invention relates to a compound selected from 5-aminolevulinic acid, 5-aminolevulinic acid ester or a salt thereof, which can stably improve acne by using a natural raw material; Bank extract; And lotus leaf extract; The present invention relates to a composition for improving acne, a composition for improving dandruffiness, a composition for improving sensitive skin and dry skin, a composition for improving dermatitis, skin diseases and skin roughness.
여드름은 사춘기의 남녀의 얼굴, 특히 볼과 이마에 많은 모낭의 염증을 만한다. 가슴이나 등에 생기는 경우도 있으며 40세 무렵에서 생기는 일도 있다. 처음에는 모낭에 피질과 각질이 꽉 차서 황백색의 덩어리가 생기며 때로는 그 정점이 검게 변색하는 수도 있다. 이 때 짜면 치즈 모양의 것이 나오게 된다. 이어서 이것을 중심으로 하여 염증이 생기고 붉게 융기한다. 이것에 세균이 감염되면 화농하여 황색으로 된다. 나은 자리는 분화구 모양의 흔적이 남는다. 보통 이 4종류의 것이 혼재하고 있다. 원인으로는 선천적인 소질과 성호르몬, 특히 남성 호르몬의 작용에 의해 과다하게 분비된 피지에 세균이 감염되어 생기는 수가 많다. 22세 이후의 여성에서는 자주 월경 직전에 악화한다. 여드름의 발생 원인은 아직까지도 확실하게 밝혀져 있지 않지만 일반적으로 피지 분비의 증가, 피부 각질화 및 지질 성분의 과산화 현상, 여드름 원인균의 증식 및 염증 유발과 악화 등으로 정리할 수 있다. 여드름의 발병과 관련하여 중요한 특징 중의 하나는 피지 분비의 증가이며 이는 남성 호르몬인 안드로겐과 밀접한 관계가 있는 것으로 알려져 있다. 남성 호르몬이 정상 수준 이상으로 분비됨으로써 피지선의 기능이 항진되고 이렇게 생성된 과량의 피지가 모낭벽의 각화로 인해 모낭 내에 정체되면서 면포가 생성된다. 외부로 배출되지 못하고 모낭내에 쌓인 피지가 모공을 막아 외부 공기의 유입을 막게 됨으로써 모낭 내부는 혐기성 세균인 프로피오니박테리움 아크네스(Propionibacterium acnes)가 원활하게 증식할 수 있는 환경이 된다. 프로피오니박테리움 아크네스는 지방 분해 효소와 화학 인자를 분비하여 자유 지방산을 만들고, 백혈구의 면역 반응을 유발하여 모낭 벽이 파괴됨으로써 내용물이 진피로 유출되고 이로 인해 염증 반응이 일어나게 된다. 따라서 여드름에 대한 개괄적인 치료 방법은 과도한 피지 생성 억제, 모낭벽의 각화 억제, 프로피오니박테리움 아크네스의 증식 억제 및 염증 반응의 최소화 또는 억제 등의 네 가지 경우로 요약할 수 있다.
Acne affects the face of men and women of puberty, especially the bones and forehead of many hair follicles. It may occur in the chest or back, and it may occur in around 40 years old. At first, the hair follicles are full of cortex and keratin, resulting in yellowish white lumps, sometimes with a black discoloration. When we squeeze out, cheese comes out. This is followed by inflammation and red bumps. When bacteria are infected with this, it becomes yellowish by purging. The better place remains a crater-like trail. Usually these four kinds are mixed. The cause is that many bacteria are infected with sebum which is excessively secreted by the action of congenital and sex hormones, especially male hormone. Women 22 years and older often worsen immediately before menstruation. The cause of acne has not yet been clarified yet. However, in general, it can be summarized as an increase in sebum secretion, skin keratinization, peroxidation of lipid components, proliferation of acne causing bacteria, and inflammation induction and deterioration. One of the most important features of the acne epidemic is the increase in sebum secretion, which is known to be closely related to the male hormone, androgens. The male hormone is secreted above the normal level and the function of the sebaceous gland is exaggerated, and the excess sebum produced in the hair follicle is stagnated in the hair follicle due to the keratinization of the hair follicle wall, resulting in the formation of cotton glands. The feces accumulated in the hair follicles can not be discharged to the outside, and the pores are blocked to prevent the inflow of outside air, whereby the inside of the hair follicle becomes an environment in which the anaerobic bacteria, Propionibacterium acnes , can grow smoothly. Propionibacterium acnes produces free fatty acids by secretion of lipolytic enzymes and chemical factors, and induces an immune response of leukocytes, resulting in the breakage of the hair follicle wall, which causes the contents to flow out into the dermis, resulting in an inflammatory reaction. Therefore, the general treatment method for acne can be summarized as four cases: suppression of excessive sebum production, inhibition of keratinization of the hair follicle wall, inhibition of proliferation of propionibacterium acnes, and minimization or inhibition of inflammatory reaction.
이에, 본 발명은 상술한 문제점을 해결하기 위하여 창출된 것으로, 5-아미노레불린산, 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물; 은행추출물; 및 연잎추출물; 을 원료로 한 조성물이 햇빛에 반응하면서 여드름균을 억제시키고 여드름의 원인인 피지선이 작아져서 피지 배출을 줄일 수 있다는 점을 확인함으로써 여드름 개선 또는 치료 효과가 탁월한 여드름 개선 또는 치료용 화장품 또는 식품을 제공하는 것 뿐만 아니라 기미·잡티의 개선 및 예방, 민감성 피부, 건성 피부, 피부 거침, 피부염, 피부질환의 개선 및 피부 미용에 효과가 있는 화장품 또는 식품을 제공하는데 그 목적이 있다.
SUMMARY OF THE INVENTION Accordingly, the present invention has been made to solve the above-mentioned problems, and its object is to provide a compound selected from 5-aminolevulinic acid, 5-aminolevulinic acid ester or a salt thereof; Bank extract; And lotus leaf extract; The present invention provides a cosmetic product or food for improving or treating acne which is excellent in acne improvement or therapeutic effect by confirming that the composition containing the ingredient as a raw material can suppress the acne bacterium and reduce the sebaceous gland which is the cause of acne, And to provide cosmetics or foods which are effective for improving and preventing spots and dullness, for improving sensitive skin, dry skin, roughness, dermatitis, skin diseases, and skin care.
본 발명은 하기 화학식 1로 표시되는 5-아미노레불린산, 화학식 2로 표시되는 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물; 은행추출물; 및 연잎추출물; 을 포함하는 조성물이다.
The present invention relates to a compound selected from 5-aminolevulinic acid represented by the following formula (1), 5-aminolevulinic acid ester represented by the formula (2) or a salt thereof; Bank extract; And lotus leaf extract; ≪ / RTI >
[화학식 1][Chemical Formula 1]
[화학식 2](2)
상기 화학식 2에서, R은 치환되거나 치환되지 않은 C1 내지 C10의 알킬기이다.In Formula 2, R is a substituted or unsubstituted C 1 to C 10 alkyl group.
상세하게 상기 화합물은 R이 치환되지 않은 C1 내지 C4의 알킬기인 것을 특징으로 하는 조성물이다.In detail, the compound is a composition wherein R is an unsubstituted C 1 to C 4 alkyl group.
상기 5-아미노레불린산, 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물:은행추출물:연잎추출물은 1:0.25~1:0.25~1의 중량비로 배합되는 것을 특징으로 하는 조성물이다.A compound selected from the group consisting of the 5-aminolevulinic acid and the 5-aminolevulinic acid ester or a salt thereof, wherein the ginkgo extract is in a weight ratio of 1: 0.25 to 1: 0.25 to 1.
또한 상기 조성물은 히아루론산, 세테아릴알코올, 비즈왁스, 세테아릴글루코사이드, 호호바씨오일, 살구씨오일, 우엉추출물, 레몬추출물, 호프추출물, 서양고추나물추출물, 세이지잎추출물, 카렌둘라꽃추출물, 비누풀추출물, 초피나무열매추출물, 디소듐아데노신트리포스페이트, 알긴, 파파야열매추출물, 마치현추출물, 폴리아크릴레이트-13, 폴리이소부텐, 폴리소르베이트, 소듐폴리아크릴레이트, 에칠헥실스테아레이트, 트리데세스-6, 디소듐이디티에이, 포타슘하이드록사이드, 글리세릴스테아레이트, 피이지-100 스테아레이트, 스쿠알란, 디메치콘, 나이아신아마이드, 토코페릴아세테이트 및 디포타슘글리시리제이트로 이루어진 군에서 선택된 어느 하나 이상의 화합물을 추가로 포함한 조성물이다.The composition may further comprise at least one selected from the group consisting of hyaluronic acid, cetearyl alcohol, beeswax, cetearyl glucoside, jojoba seed oil, apricot seed oil, burdock extract, lemon extract, hop extract, horseradish extract, sage leaf extract, Polyphenylene sulfide, polysorbate, sodium polyacrylate, ethylhexyl stearate, tridecyl sulphate, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl pyrrolidone, polyvinyl pyrrolidone, Which is selected from the group consisting of Seth-6, disodium iodide, potassium hydroxide, glyceryl stearate, phage-100 stearate, squalane, dimethicone, niacinamide, tocopheryl acetate and dipotassium glycyrrhizae Is a composition further comprising at least one compound.
상기 조성물은 여드름 개선, 기미·잡티의 개선, 민감성 피부 및 건성 피부 개선, 피부염, 피부질환 및 피부거침 개선을 위해 사용되는 것을 특징으로 하는 조성물이다.The composition is used for improvement of acne, improvement of stain and dullness, improvement of sensitive skin and dry skin, dermatitis, skin disease and improvement of roughness of skin.
본 발명은 제 1항 또는 제 4항의 조성물을 포함하는 화장료 조성물이다.The present invention is a cosmetic composition comprising the composition of any one of claims 1 to 4.
본 발명은 제 1항 또는 제 4항의 조성물을 포함하는 식품 조성물이다.The present invention is a food composition comprising the composition of any one of claims 1 to 4.
상기 화장료 조성물의 제형은 유연 화장수, 영양 화장수, 영양 크림, 마사지 크림, 에센스, 아이크림, 비비크림, 클렌징 크림, 클렌징 폼, 클렌징 워터, 팩, 스프레이 및 파우더로 이루어진 군에서 선택된 어느 하나인 것을 특징으로 하는 조성물이다.The formulation of the cosmetic composition is any one selected from the group consisting of a soft lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a babe cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray and a powder .
상기 식품 조성물의 제형은 껌류, 비타민 복합제, 건강 보조식품, 특수 영향 보충용 식품, 음료로 이루어진 군에서 선택된 어느 하나인 것을 특징으로 하는 조성물이다.
Wherein the formulation of the food composition is any one selected from the group consisting of gums, a vitamin complex, a health supplement, a special effect supplement food, and a drink.
본 발명에 따른 조성물은 5-아미노레불린산, 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물; 은행추출물; 및 연잎추출물을 함유함으로써 이러한 화합물이 대사되어 프로토포피린(protoporphyrin)을 함유하게 되어 햇빛에 반응하면서 여드름균을 억제시키고 여드름의 원인인 피지선이 작아져서 피지 배출을 줄일 수 있어 여드름 개선 또는 치료 효과가 탁월하므로, 여드름 개선 또는 치료용 화장품 또는 식품 등으로 개발 가능하다.The composition according to the present invention is a compound selected from 5-aminolevulinic acid, 5-aminolevulinic acid ester or a salt thereof; Bank extract; And the extract of the lotus leaves, the compound is metabolized to contain protoporphyrin, so that it reacts with sunlight to suppress acne bacterium, sebaceous gland which is the cause of acne is reduced, sebum emission can be reduced and acne improvement or treatment effect is excellent Therefore, it can be developed as cosmetics for improving or treating acne, food or the like.
상기 조성물은 히아루론산, 세테아릴알코올, 비즈왁스, 세테아릴글루코사이드, 호호바씨오일, 살구씨오일, 우엉추출물, 레몬추출물, 호프추출물, 서양고추나물추출물, 세이지잎추출물, 카렌둘라꽃추출물, 비누풀추출물, 초피나무열매추출물, 디소듐아데노신트리포스페이트, 알긴, 파파야열매추출물, 마치현추출물, 폴리아크릴레이트-13, 폴리이소부텐, 폴리소르베이트, 소듐폴리아크릴레이트, 에칠헥실스테아레이트, 트리데세스-6, 디소듐이디티에이, 포타슘하이드록사이드, 글리세릴스테아레이트, 피이지-100 스테아레이트, 스쿠알란, 디메치콘, 나이아신아마이드, 토코페릴아세테이트 및 디포타슘글리시리제이트로 이루어진 군에서 선택된 어느 하나 이상의 화합물을 추가로 포함하여 상기 개선 또는 치료 효과를 향상시킬 수 있다.
Wherein the composition is selected from the group consisting of hyaluronic acid, cetearyl alcohol, beeswax, cetearyl glucoside, jojoba seed oil, apricot seed oil, burdock extract, lemon extract, hops extract, horseradish extract, sage leaf extract, Extracts of papaya, extracts of papaya, extracts of horsetail, polyacrylate-13, polyisobutene, polysorbate, sodium polyacrylate, ethylhexyl stearate, tridecethol, One selected from the group consisting of disodium ditallow, potassium hydroxide, glyceryl stearate, phage-100 stearate, squalane, dimethicone, niacinamide, tocopheryl acetate and dipotassium glycyrrhizate The above-mentioned compounds may further be included to improve the improvement or therapeutic effect.
본 발명의 양태는 5-아미노레불린산, 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물; 은행추출물; 및 연잎추출물; 을 포함하는 것이다.
An embodiment of the present invention is a compound selected from 5-aminolevulinic acid, 5-aminolevulinic acid ester or a salt thereof; Bank extract; And lotus leaf extract; .
상기 화학식 2에서, R은 2-프로필기, 3-부틸기, 4-펜틸기, 5-헥실기 로 이루어지는 군에서 선택될 수 있다.In Formula 2, R may be selected from the group consisting of a 2-propyl group, a 3-butyl group, a 4-pentyl group, and a 5-hexyl group.
또한, (a) 상기 화학식 2 화합물을 치오닐 클로라이드 및 N,N-디메칠포름아마이드와 반응시키는 단계; 및 (b) 상기 (a) 단계에서 얻어진 물질을 3-부탄올(3-butanol), 4-펜탄올(4-pentanol), 5-헥산올(5-hexanol)로 이루어지는 군에서 선택된 포화 알코올과 반응시키는 단계;를 포함하는 제조방법을 통해 얻어지는 상기 5-아미노레불린산 포화 알킬 에스터의 염을 함유하는 조성물을 제공한다.
(A) reacting the compound of formula 2 with thionyl chloride and N, N-dimethylformamide; And (b) reacting the material obtained in step (a) with a saturated alcohol selected from the group consisting of 3-butanol, 4-pentanol and 5-hexanol. And a salt of the 5-aminolevulinic acid saturated alkyl ester obtained through a process comprising the steps of:
은행(Ginkgo, Ginkgo biloba Linnaeus)은 은행나무과에 속하는 낙엽교목으로 중국, 한국, 일본의 고산, 고원지대를 제외한 온대에 분포에 분포하며 줄기, 잎, 열매 등으로 구성되어 있다. 이러한 은행은 플라보노이드 글리코시드 성분을 포함하여 혈액순환 촉진 및 신진대사 기능을 갖는 것으로 알려져 있다.
Ginkgo (Ginkgo biloba Linnaeus) is a deciduous tree belonging to the Ginkgo biloba , distributed in the temperate zone except for the high mountains and highlands of China, Korea and Japan. It is composed of stem, leaf and fruit. These banks are known to have blood circulation promotion and metabolic functions including flavonoid glycoside components.
연잎은 미나리아재비목 수련과의 여러해살이 수초로서 연(Nelumbo nucifera)이라고도 한다. 비타민 C와 비타민 B12 및 아스파라긴, 아르기닌, 티로신 같은 아미노산이 함유되어 있어 피로회복 및 피부미용 개선 작용 등에 효과가 있음은 물론 로에메린(roemerine)과 누시페린(nuciferine) 성분의 진통 진정 작용이 있어 신경과민이나 스트레스 등에 효과가 있고 민간에서는 폐렴, 기관지천식, 임질, 강장, 소화불량 뿐만 아니라 뱀과 독벌레에 물렸을 때 사용하는 것으로 알려져 있다. 연잎은 가능한 6월 초순부터 10월 중순에 채취하게 되는데 통상 연잎은 6월 초순에 나기 시작해서 10월 중순이 되면 연잎이 퇴색하기 때문에 가능한 그 전에 채취하여 사용한다. 본 발명에서 사용되는 연잎은, 하엽이라고도 하며 약리적인 작용으로는 설사, 두통과 어지럼증, 토혈, 코피 등 출혈증, 산후 어혈치료, 야뇨증에 쓰이고 있으며, 각종 독성물질에 대한 중화작용을 한다. 특히 흡연자에게는 니코틴을 제거시켜 주는 해독작용이 있다. 또한 일반적으로 연잎은 해독효과와 함께 피를 맑게 해주며, 지혈작용, 항균작용과 혈압저하 작용이 있는 것으로 알려져 있고 특히 동의보감에서는 연잎의 꼭지를 특별히 하비라 부르며 이 부분이 임신한 여성의 태를 편안하게 해 주고 나쁜 피를 없애주는 효과가 있다고 알려준다. 연잎을 이용한 차로는 중국 고래의 감비차(연잎, 율무, 산사자, 진피 등 함유)가 있는데, 다이어트와 피부미용에 효과가 있는 것으로 알려져 있다.
It is also called Nelumbo nucifera , which is a perennial herb with a buttercup. It contains vitamin C and vitamin B12 and amino acids such as asparagine, arginine and tyrosine. It is effective for relieving fatigue and improving skin. It also has analgesic effect of roemerine and nuciferine, And stress. In the private sector, it is known to be used for pneumonia, bronchial asthma, gonorrhea, stomach, indigestion as well as for snake and caterpillars. The lotus leaves are collected from the beginning of June to the middle of October as possible. Normally, the lotus leaves start to appear in early June, and when they are in mid-October, they are discarded. The lotus leaf used in the present invention is also referred to as a lower leaf, and its pharmacological action is used for diarrhea, headache and dizziness, hemorrhage such as hematemesis, nose bleeding, postpartum hemorrhage treatment, enuresis, and neutralization of various toxic substances. Especially smokers have a detoxifying action that removes nicotine. In addition, it is generally known that the lotus leaves cleanse the blood with detoxifying effect, and it is known to have a hemostatic effect, an antibacterial effect and a blood pressure lowering effect. Especially, And that it has the effect of eliminating bad blood. There are Chinese caramel carp (tea leaves, yulmu, horseradish, dandelion, etc.), which is said to be effective for diet and skin beauty.
본 발명의 조성물에 포함되는 상기 각 식물 원료의 추출물은 건조상태 또는 자연상태의 원료를 추출하여 이용할 수 있으며 추출효율을 높이기 위해, 분절 또는 분쇄시켜 이용할 수 있다. 또한 상기 각 식물 추출물은 다양한 기관 또는 부분, 즉, 열매, 잎, 꽃, 줄기, 가지 및 껍질 등에서 추출할 수 있다. 은행의 경우 바람직하게는 열매로부터 추출할 수 있다. 상기 추출물은 당업계에 공지된 다양한 추출 방법을 이용하여 수득할 수 있으며, 바람직하게는, (a) 물, (b) 탄소수 1-4의 무수 또는 함수 저급 알코올 (메탄올, 에탄올, 프로판올, 부탄올 등), (c) 상기 저급 알코올과 물과의 혼합용매, (d) 아세톤, (e) 에틸 아세테이트, (f) 클로로포름 또는 (g) 1,3-부틸렌글리콜 등을 추출용매로 하여 수득할 수 있다. 또한 본 발명에서 이용된 추출물은 상기한 추출 용매 뿐만 아니라, 다른 추출 용매를 이용하여도 실질적으로 동일한 효과를 나타내는 추출물이 얻어질 수 있다는 것은 당업자에게 자명한 것이다.
The extract of each of the botanical raw materials contained in the composition of the present invention can be used by extracting raw materials in a dry state or in a natural state and can be used by segmenting or grinding to enhance extraction efficiency. Further, each of the plant extracts can be extracted from various organs or parts, i.e., fruits, leaves, flowers, stems, branches and shells. In the case of a bank, it can be preferably extracted from the fruit. The extract may be obtained by using various extraction methods known in the art. Preferably, (a) water, (b) an anhydrous or a lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, ), (c) a mixed solvent of the lower alcohol and water, (d) acetone, (e) ethyl acetate, (f) chloroform or (g) 1,3-butylene glycol have. It is obvious to those skilled in the art that the extract used in the present invention can be obtained not only by the above-mentioned extraction solvent but also by using other extraction solvent, which exhibits substantially the same effect.
본 발명의 상기 조성물은 5-아미노레불린산, 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물; 은행추출물; 및 연잎추출물; 을 동시에 포함할 때 각 재료의 유용성분 간에 상승작용이 발생하여 노화 방지, 염증 억제, 피부 미백 또는 주름 개선 효능을 효과적으로 증진시킬 수 있으며, 일정 조성비로 포함할 때, 이러한 효능을 더욱 월등하게 증진시킬 수 있다.The composition of the present invention is a compound selected from 5-aminolevulinic acid, 5-aminolevulinic acid ester or a salt thereof; Bank extract; And lotus leaf extract; A synergistic action occurs between the useful components of each material to effectively enhance the anti-aging, anti-inflammatory, skin whitening or wrinkle-reducing effects, and when the composition is contained at a certain composition ratio, .
본 발명의 조성물은 5-아미노레불린산, 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물; 은행추출물; 및 연잎추출물;을 1:0.25~1:0.25~1의 중량비로 함유할 수 있다. 이러한 혼합비 범위에서 피부 자극 없이 항균, 피부 재생, 피지 분비 억제, 피부 진정 및 미백 기능 증진을 통한 탁월한 여드름 개선 효과를 기대할 수 있으며, 상기 조성 비율을 벗어나면 여드름 개선 효과가 떨어지는 문제가 있다. 또한 본 발명에서 은행추출물:연잎추출물은 1:0.25~4의 중량비로 배합되었을 때 우수한 효과를 얻을 수 있다.The composition of the present invention is a compound selected from 5-aminolevulinic acid, 5-aminolevulinic acid ester or a salt thereof; Bank extract; And a lotus leaf extract at a weight ratio of 1: 0.25 to 1: 0.25 to 1. In such a mixing ratio range, excellent acne improvement effect can be expected through antibacterial, skin regeneration, suppression of sebum secretion, skin soothing and whitening function without skin irritation, and there is a problem that the improvement effect of acne is deteriorated when the above composition ratio is exceeded. In addition, in the present invention, the ginkgo leaf extract has an excellent effect when it is blended at a weight ratio of 1: 0.25 ~ 4.
본 발명의 상기 조성물은 5-아미노레불린산, 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물; 은행추출물; 및 연잎추출물; 외에도 본 발명의 유효 활성을 저해하지 않는 범위에서 여드름 개선을 위해 상기 히아루론산 등의 군에서 선택된 하나 이상의 화합물을 추가로 포함시켜 이용할 수 있다.The composition of the present invention is a compound selected from 5-aminolevulinic acid, 5-aminolevulinic acid ester or a salt thereof; Bank extract; And lotus leaf extract; In addition, one or more compounds selected from the group consisting of hyaluronic acid and the like may be further included for the purpose of improving acne within a range not inhibiting the active activity of the present invention.
본 발명에서 상기 조성물은 여드름 개선, 기미·잡티의 개선, 민감성 피부 및 건성 피부 개선, 피부염, 피부질환 및 피부거침 개선을 위해 사용되는 것을 특징으로 하는 조성물로, 상기 조성물은 화장료 조성물 또는 식품 조성물로 사용할 수 있다.The composition of the present invention is used for improvement of acne, improvement of stain and dullness, improvement of sensitive skin and dry skin, dermatitis, skin disease and improvement of roughness of skin. The composition is used as cosmetic composition or food composition Can be used.
상기 화장료 조성물의 제형은 유연 화장수, 영양 화장수, 영양 크림, 마사지 크림, 에센스, 아이크림, 비비크림, 클렌징 크림, 클렌징 폼, 클렌징 워터, 팩, 스프레이 및 파우더로 이루어진 군에서 선택된 어느 하나인 것을 특징으로 하는 조성물이다.The formulation of the cosmetic composition is any one selected from the group consisting of a soft lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a babe cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray and a powder .
상기 식품 조성물의 제형은 껌류, 비타민 복합제, 건강 보조식품, 특수 영향 보충용 식품, 음료로 이루어진 군에서 선택된 어느 하나인 것을 특징으로 하는 조성물이다.
Wherein the formulation of the food composition is any one selected from the group consisting of gums, a vitamin complex, a health supplement, a special effect supplement food, and a drink.
이하, 본 발명의 이해를 돕기 위하여 실시예를 들어 상세하게 설명한다. 그러나 본 발명에 따른 실시예들은 여러 가지 다른 형태로 변형될 수 있으며 본 발명의 범위가 하기 실시예에 한정되는 것은 아니다. 본 발명의 실시예들은 당업계에서 평균적인 지식을 가진 자들이 본 발명을 보다 완벽하게 이해할 수 있도록 설명하기 위해 제공된다.
Hereinafter, embodiments of the present invention will be described in detail in order to facilitate understanding of the present invention. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention is not limited to the following embodiments. Embodiments of the invention are provided to enable those of ordinary skill in the art to more fully understand the present invention.
본 발명자들은 상기와 같은 종래의 문제점을 해결하기 위해 인체 피부에 보다 친화적인 천연물 및 한약재 추출물들에 대해 연구한 결과, 5-아미노레불린산, 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물; 은행추출물; 및 연잎추출물; 로 구성된 조성물이 햇빛에 반응하면서 여드름을 억제시키고 여드름의 원인인 피지선이 작아져서 피지 배출울 줄일 수 있다는 탁월한 효과가 있음을 발견하고 본 발명을 완성하게 되었다. 본 발명에 따른 실험 결과에 기초할 때 본 발명의 화장료 조성물은 5-아미노레불린산, 5-아미노레불린산 에스테르 또는 그의 염에서 선택되는 화합물; 은행추출물; 및 연잎추출물; 을 사용 할 때 여드름 개선 효과가 놀라울 정도로 상승하는 것을 확인하였다.
DISCLOSURE OF THE INVENTION The present inventors have studied natural materials and herbal extracts which are more friendly to human skin in order to solve the above-mentioned conventional problems. As a result, they have found that 5-aminolevulinic acid, 5-aminolevulinic acid ester, compound; Bank extract; And lotus leaf extract; Has an excellent effect of suppressing acne while reacting with sunlight and reducing the sebaceous gland, which is the cause of acne, to reduce sebum discharge, thus completing the present invention. Based on the results of the experiment according to the present invention, the cosmetic composition of the present invention is a compound selected from 5-aminolevulinic acid, 5-aminolevulinic acid ester or a salt thereof; Bank extract; And lotus leaf extract; , It was confirmed that the acne improvement effect was remarkably increased.
하기 실험예 1에 의하면, 실시예 1 내지 실시예 4의 조성물은 여드름 완화효과를 인정할 수 있는 '크게 개선' 및 '약간 개선'을 보인 시험자의 비율(여드름개선효율)이 65~85% 사이를 나타내며 특히, 은행추출물 및 연잎추출물의 함유에 따라 놀랍게 향상된 여드름 완화효과를 보여주고 있음을 알 수 있다. 반면, 실험예 2에 의하면, 비교예 1 에서 은행추출물 및 연잎추출물이 함유되지 않은 경우 여드름 개선 효과를 인정할 수 있는 시험자의 비율이 50.0%에 불과하여 상기 추출물이 함유된 경우에 비해 여드름 개선 효과가 눈에 띄게 감소하였다. 또한, 비교예 2 내지 비교예 7을 통해 은행추출물 및 연잎추출물이 효과적인 여드름 개선효과를 보이는 중량% 범위를 확인할 수 있었다. 상기 결과로부터 본 발명에 따른 조성물이 놀라운 여드름 개선 효과를 보여주고 있음을 확인하였다.
According to the following Experimental Example 1, the compositions of Examples 1 to 4 showed that the ratio of the testees (acne improvement efficiency) showing 'significant improvement' and 'slight improvement' which can recognize the acne mitigation effect was between 65 and 85% , And it is shown that the effect of acne reduction is remarkably improved depending on the contents of the bank extract and the lotus leaf extract. On the other hand, according to Experimental Example 2, in the case of Comparative Example 1, when the extract of the bank and the lotus leaf were not contained, the ratio of the testee who can recognize the acne improvement effect was only 50.0% Respectively. In addition, through the comparative examples 2 to 7, it was confirmed that the bank extract and the lotus leaf extract have a weight percentage range showing an effective acne improvement effect. From the above results, it was confirmed that the composition according to the present invention shows remarkable acne improvement effect.
(실시예 1) 1 중량%의 5-아미노레불린산 2-프로필 염산염과 0.8 중량% 은행추출물, 0.8 중량% 연잎추출물 함유 조성물 제조(Example 1) Preparation of composition containing 1 wt% 5-aminolevulinic acid 2-propyl hydrochloride, 0.8 wt% bank extract, 0.8 wt%
5-아미노레불린산 2-프로필 염산염은 치오닐 클로라이드(thionyl chloride, SOCl2) 1ml에 N,N-dimethylformaide (DMF)를 3방울을 넣고 저어준 다음 5-아미노레불린산 염산염(ALA,HCl, 200 mg, 1.19 mmol)을 넣고 반응물을 상온에서 12시간 동안 저어주었다. 상기 반응물을 감압하에서 농축시키고 알릴 알콜을 넣어주었다. 상기 반응 혼합물을 상온에서 1.5시간 저어주고 감압하에서 농축하여 실리카겔을 이용하여 정제하여 5-아미노레불린산 2-프로필 염산염을 73%의 수율로 얻었다.5-Aminolevulinic acid 2-propyl hydrochloride is prepared by adding 3 drops of N, N-dimethylformamide (DMF) to 1 ml of thionyl chloride (SOCl 2 ), adding 5-aminolevulinic acid hydrochloride (ALA, HCl , 200 mg, 1.19 mmol) and the reaction was stirred at room temperature for 12 hours. The reaction was concentrated under reduced pressure and allyl alcohol was added. The reaction mixture was stirred at room temperature for 1.5 hours, concentrated under reduced pressure and purified by silica gel to obtain 5-aminolevulinic acid 2-propyl hydrochloride in a yield of 73%.
디프로필렌 글라이콜 70.0 중량%, 5-아미노레불린산 2-프로필 염산염 1.0 중량%, 은행추출물 0.8 중량%, 연잎추출물 0.8 중량% 및 정제수를 가하여 전량을 100 중량%로 한 다음 충분히 교반하여 조성물을 제조하였다.1.0% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.8% by weight of bank extract, 0.8% by weight of leaf extract, and purified water were added to make 100% .
(실시예 2) 1 중량%의 5-아미노레불린산 2-프로필 염산염과 0.8 중량% 은행추출물, 0.4 중량% 연잎추출물 함유 조성물 제조(Example 2) Preparation of composition containing 1 wt% of 5-aminolevulinic acid 2-propyl hydrochloride, 0.8 wt% of bank extract, 0.4 wt% of lotus leaf extract
5-아미노레불린산 2-프로필 염산염의 제조과정은 실시예 1과 같다.The process for producing 5-aminolevulinic acid 2-propyl hydrochloride is the same as in Example 1.
디프로필렌 글라이콜 70.0 중량%, 5-아미노레불린산 2-프로필 염산염 1.0 중량%, 은행추출물 0.8 중량%, 연잎추출물 0.4 중량% 및 정제수를 가하여 전량을 100 중량%로 한 다음 충분히 교반하여 조성물을 제조하였다.1.0% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.8% by weight of bank extract, 0.4% by weight of leaf extract, and purified water were added to make 100% .
(실시예 3) 1 중량%의 5-아미노레불린산 2-프로필 염산염과 0.4 중량% 은행추출물, 0.8 중량% 연잎추출물 함유 조성물 제조(Example 3) Preparation of composition containing 1% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.4% by weight of bank extract and 0.8% by weight of lotus leaf extract
5-아미노레불린산 2-프로필 염산염의 제조과정은 실시예 1과 같다.The process for producing 5-aminolevulinic acid 2-propyl hydrochloride is the same as in Example 1.
디프로필렌 글라이콜 70.0 중량%, 5-아미노레불린산 2-프로필 염산염 1.0 중량%, 은행추출물 0.4 중량%, 연잎추출물 0.8 중량% 및 정제수를 가하여 전량을 100 중량%로 한 다음 충분히 교반하여 조성물을 제조하였다.1.0% by weight of dipropylene glycol, 1.0% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.4% by weight of bank extract, 0.8% by weight of lotus leaf extract and purified water to adjust the total amount to 100% .
(실시예 4) 1 중량%의 5-아미노레불린산 2-프로필 염산염과 0.4 중량% 은행추출물, 0.4 중량% 연잎추출물 함유 조성물 제조(Example 4) Preparation of a composition containing 1% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.4% by weight of a bank extract and 0.4%
5-아미노레불린산 2-프로필 염산염의 제조과정은 실시예 1과 같다.The process for producing 5-aminolevulinic acid 2-propyl hydrochloride is the same as in Example 1.
디프로필렌 글라이콜 70.0 중량%, 5-아미노레불린산 2-프로필 염산염 1.0 중량%, 은행추출물 0.4 중량%, 연잎추출물 0.4 중량% 및 정제수를 가하여 전량을 100 중량%로 한 다음 충분히 교반하여 조성물을 제조하였다.
1.0% by weight of dipropylene glycol, 1.0% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.4% by weight of bank extract, 0.4% by weight of lotus leaf extract and purified water were added to make 100% .
(비교예 1) 1 중량%의 5-아미노레불린산 2-프로필 염산염 함유 조성물 제조(Comparative Example 1) Preparation of 1 wt% 5-aminolevulinic acid 2-propyl hydrochloride-containing composition
5-아미노레불린산 2-프로필 염산염의 제조과정은 실시예 1과 같다.The process for producing 5-aminolevulinic acid 2-propyl hydrochloride is the same as in Example 1.
디프로필렌 글라이콜 70.0 중량%, 5-아미노레불린산 2-프로필 염산염 1.0 중량% 및 정제수를 가하여 전량을 100 중량%로 한 다음 충분히 교반하여 조성물을 제조하였다.70.0% by weight of dipropylene glycol, 1.0% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, and purified water were added to make the total amount 100% by weight, followed by thorough stirring to prepare a composition.
(비교예 2) 1 중량%의 5-아미노레불린산 2-프로필 염산염과 0.8 중량% 연잎추출물 함유 조성물 제조(Comparative Example 2) Preparation of composition containing 1% by weight of 5-aminolevulinic acid 2-propyl hydrochloride and 0.8% by weight of lotus leaf extract
5-아미노레불린산 2-프로필 염산염의 제조과정은 실시예 1과 같다.The process for producing 5-aminolevulinic acid 2-propyl hydrochloride is the same as in Example 1.
디프로필렌 글라이콜 70.0 중량%, 5-아미노레불린산 2-프로필 염산염 1.0 중량%, 연잎추출물 0.8 중량% 및 정제수를 가하여 전량을 100 중량%로 한 다음 충분히 교반하여 조성물을 제조하였다.1.0% by weight of dipropylene glycol, 1.0% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.8% by weight of leaf extract, and purified water were added to adjust the total amount to 100% by weight, followed by thorough stirring to prepare a composition.
(비교예 3) 1 중량%의 5-아미노레불린산 2-프로필 염산염과 0.8 중량% 은행추출물 함유 조성물 제조(Comparative Example 3) Preparation of composition containing 1 wt% of 5-aminolevulinic acid 2-propyl hydrochloride and 0.8 wt% of bank extract
5-아미노레불린산 2-프로필 염산염의 제조과정은 실시예 1과 같다.The process for producing 5-aminolevulinic acid 2-propyl hydrochloride is the same as in Example 1.
디프로필렌 글라이콜 70.0 중량%, 5-아미노레불린산 2-프로필 염산염 1.0 중량%, 은행추출물 0.8 중량% 및 정제수를 가하여 전량을 100 중량%로 한 다음 충분히 교반하여 조성물을 제조하였다.The composition was prepared by mixing 70.0% by weight of dipropylene glycol, 1.0% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.8% by weight of a bank extract and purified water to make the total amount 100% by weight.
(비교예 4) 1 중량%의 5-아미노레불린산 2-프로필 염산염과 0.8 중량% 은행추출물, 0.1 중량% 연잎추출물 함유 조성물 제조(Comparative Example 4) Preparation of composition containing 1% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.8% by weight of bank extract and 0.1%
5-아미노레불린산 2-프로필 염산염의 제조과정은 실시예 1과 같다.The process for producing 5-aminolevulinic acid 2-propyl hydrochloride is the same as in Example 1.
디프로필렌 글라이콜 70.0 중량%, 5-아미노레불린산 2-프로필 염산염 1.0 중량%, 은행추출물 0.8 중량%, 연잎추출물 0.1 중량% 및 정제수를 가하여 전량을 100 중량%로 한 다음 충분히 교반하여 조성물을 제조하였다.1.0% by weight of dipropylene glycol, 1.0% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.8% by weight of bank extract, 0.1% by weight of lotus leaf extract and purified water to adjust the total amount to 100% .
(비교예 5) 1 중량%의 5-아미노레불린산 2-프로필 염산염과 0.8 중량% 은행추출물, 1.5 중량% 연잎추출물 함유 조성물 제조(Comparative Example 5) Preparation of composition containing 1% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.8% by weight of bank extract and 1.5% by weight of lotus leaf extract
5-아미노레불린산 2-프로필 염산염의 제조과정은 실시예 1과 같다.The process for producing 5-aminolevulinic acid 2-propyl hydrochloride is the same as in Example 1.
디프로필렌 글라이콜 70.0 중량%, 5-아미노레불린산 2-프로필 염산염 1.0 중량%, 은행추출물 0.8 중량%, 연잎추출물 1.5 중량% 및 정제수를 가하여 전량을 100 중량%로 한 다음 충분히 교반하여 조성물을 제조하였다.1.0% by weight of dipropylene glycol, 1.0% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.8% by weight of bank extract, 1.5% by weight of leaf extract and purified water were added to make 100% .
(비교예 6) 1 중량%의 5-아미노레불린산 2-프로필 염산염과 0.1 중량% 은행추출물, 0.8 중량% 연잎추출물 함유 조성물 제조(Comparative Example 6) Preparation of composition containing 1% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.1% by weight of bank extract and 0.8% by weight of lotus leaf extract
5-아미노레불린산 2-프로필 염산염의 제조과정은 실시예 1과 같다.The process for producing 5-aminolevulinic acid 2-propyl hydrochloride is the same as in Example 1.
디프로필렌 글라이콜 70.0 중량%, 5-아미노레불린산 2-프로필 염산염 1.0 중량%, 은행추출물 0.1 중량%, 연잎추출물 0.8 중량% 및 정제수를 가하여 전량을 100 중량%로 한 다음 충분히 교반하여 조성물을 제조하였다.1.0% by weight of dipropylene glycol, 1.0% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 0.1% by weight of bank extract, 0.8% by weight of leaf extract and purified water to make the total amount to 100% .
(비교예 7) 1 중량%의 5-아미노레불린산 2-프로필 염산염과 1.5 중량% 은행추출물, 0.8 중량% 연잎추출물 함유 조성물 제조(Comparative Example 7) Preparation of composition containing 1% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 1.5% by weight of bank extract and 0.8% by weight of lotus leaf extract
5-아미노레불린산 2-프로필 염산염의 제조과정은 실시예 1과 같다.The process for producing 5-aminolevulinic acid 2-propyl hydrochloride is the same as in Example 1.
디프로필렌 글라이콜 70.0 중량%, 5-아미노레불린산 2-프로필 염산염 1.0 중량%, 은행추출물 1.5 중량%, 연잎추출물 0.8 중량% 및 정제수를 가하여 전량을 100 중량%로 한 다음 충분히 교반하여 조성물을 제조하였다.
1.0% by weight of 5-aminolevulinic acid 2-propyl hydrochloride, 1.5% by weight of a ginkgo extract, 0.8% by weight of a lotus leaf extract and purified water to adjust the total amount to 100% by weight, .
(실험예 1) 여드름 개선 또는 치료 효과 검토(Experimental Example 1) Examination of acne improvement or therapeutic effect
실시예 1 내지 실시예 4에 따른 조성물의 여드름 완화 효과를 검토하기 위하여, 여드름을 가지고 있는 20세에서 30세 사이의 건강한 성인 남녀 50명에 대하여 블라인드 테스트(blind test)를 실시하였다. 50명의 남녀에게 실시예 1 내지 실시예 4에 따른 조성물 각각을 1일 2회씩 2개월간 사용하도록 하였다.In order to examine the effect of the compositions according to Examples 1 to 4 on acne relief, a blind test was conducted on 50 healthy adult men and women between the ages of 20 and 30 who had acne. 50 men and women were allowed to use the compositions according to Examples 1 to 4 twice a day for 2 months.
평가는 2주 간격으로 여드름 증상의 악화 및 완화 여부에 대한 피시험자의 설문 조사와 피부과 의사 1명의 육안적 소견을 종합하여 실시하였으며, 최종 2개월차에 평가를 완료하였다. 그 결과를 (i) 크게 개선, (ii) 약간 개선, (iii) 개선효과없음으로 각각 나누어 분석하였다.
The evaluation consisted of a questionnaire survey on the severity of acne symptoms and the gross appearance of one dermatologist at intervals of two weeks, and the evaluation was completed at the end of the second month. The results were divided into (i) significant improvement, (ii) slight improvement, and (iii) no improvement.
(실험예 2) 여드름 개선 또는 치료 효과 검토(Experimental Example 2) Review of acne improvement or therapeutic effect
비교예 1 내지 비교예 7에 따른 조성물의 여드름 완화 효과를 검토하기 위하여, 블라인드 테스트를 실시하였으며, 다른 조건은 실험예 1과 같다.
In order to examine the effect of the compositions according to Comparative Examples 1 to 7 on acne relief, a blind test was conducted.
실험예 1 및 실험예 2에 따른 결과는 각각 표 1, 표 2와 같다.
Results of Experimental Example 1 and Experimental Example 2 are shown in Tables 1 and 2, respectively.
[표 1][Table 1]
[표 2][Table 2]
Claims (9)
[화학식 1]
[화학식 2]
상기 화학식 2에서, R은 치환되지 않은 C1 내지 C10의 알킬기이다.
A compound selected from 5-aminolevulinic acid represented by the following formula (1), 5-aminolevulinic acid ester represented by the following formula (2) or a salt thereof; Bank extract; And lotus leaf extract; Aminolevulinic acid ester or a salt thereof, wherein the extract of Ganoderma lucidum extract has a weight ratio of 1: 0.25 to 1: 0.25 to 1 ≪ / RTI >
[Chemical Formula 1]
(2)
In Formula 2, R is an unsubstituted C 1 to C 10 alkyl group.
상기 화합물은 R이 치환되지 않은 C1 내지 C4의 알킬기인 것을 특징으로 하는 조성물.
The method according to claim 1,
Said compound being characterized in that R is an unsubstituted C 1 to C 4 alkyl group.
상기 조성물은 히아루론산, 세테아릴알코올, 비즈왁스, 세테아릴글루코사이드, 호호바씨오일, 살구씨오일, 우엉추출물, 레몬추출물, 호프추출물, 서양고추나물추출물, 세이지잎추출물, 카렌둘라꽃추출물, 비누풀추출물, 초피나무열매추출물, 디소듐아데노신트리포스페이트, 알긴, 파파야열매추출물, 마치현추출물, 폴리아크릴레이트-13, 폴리이소부텐, 폴리소르베이트, 소듐폴리아크릴레이트, 에칠헥실스테아레이트, 트리데세스-6, 디소듐이디티에이, 포타슘하이드록사이드, 글리세릴스테아레이트, 피이지-100 스테아레이트, 스쿠알란, 디메치콘, 나이아신아마이드, 토코페릴아세테이트 및 디포타슘글리시리제이트로 이루어진 군에서 선택된 어느 하나 이상의 화합물을 추가로 포함한 조성물.
3. The method according to claim 1 or 2,
Wherein the composition is selected from the group consisting of hyaluronic acid, cetearyl alcohol, beeswax, cetearyl glucoside, jojoba oil, apricot seed oil, burdock extract, lemon extract, hop extract, horseradish extract, sage leaf extract, Extracts of papaya, extracts of papaya, extracts of horsetail, polyacrylate-13, polyisobutene, polysorbate, sodium polyacrylate, ethylhexyl stearate, tridecethol, One selected from the group consisting of disodium ditallow, potassium hydroxide, glyceryl stearate, phage-100 stearate, squalane, dimethicone, niacinamide, tocopheryl acetate and dipotassium glycyrrhizate A composition further comprising the above compound.
A cosmetic composition for improving acne comprising the composition of claim 1.
A composition for improving acne comprising the composition of claim 1.
상기 화장료 조성물의 제형은 유연 화장수, 영양 화장수, 영양 크림, 마사지 크림, 에센스, 아이크림, 비비크림, 클렌징 크림, 클렌징 폼, 클렌징 워터, 팩, 스프레이 및 파우더로 이루어진 군에서 선택된 어느 하나인 것을 특징으로 하는 화장료 조성물.
The method according to claim 6,
The formulation of the cosmetic composition is any one selected from the group consisting of a soft lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a baboon cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray and a powder .
상기 식품 조성물의 제형은 껌류, 비타민 복합제, 건강 보조식품, 특수 영양 보충용 식품, 음료로 이루어진 군에서 선택된 어느 하나인 것을 특징으로 하는 식품 조성물.8. The method of claim 7,
Wherein the food composition is any one selected from the group consisting of gums, a vitamin complex, a health supplement, a nutritional supplement food, and a beverage.
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| Kor. J. Microbiol. Biotechnol. 2006. Vol. 34, No. 3, pp. 265-272 * |
| Kor. J. Microbiol. Biotechnol. 2006. Vol. 34, No. 3, pp. 265-272* |
| 대한피부미용학회지. 2012. 제10권 제2호 통권 제30호, pp. 405-413 * |
| 대한피부미용학회지. 2012. 제10권 제2호 통권 제30호, pp. 405-413* |
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