KR101479194B1 - Electrospinning device and method of manufacturing nanofiber mat using the electrospinning device - Google Patents

Abstract

The present invention relates to an electrospinning device and a method for manufacturing a nanofiber mat. The electrospinning device comprises: a nozzle unit discharging a polymer solution in one direction, where DC voltage is applied; a drum collector facing the nozzle unit and accumulating the polymer solution, where ground voltage is applied; and a plurality of side electrodes arranged between the nozzle unit and the drum collector, and arranged to face each other in the extended direction of the rotation axis of the drum collector, where voltage of the same polarity with DC voltage applied to the nozzle unit is applied.

Description

FIELD OF THE INVENTION [0001] The present invention relates to an electrospinning device and a method of manufacturing the same. More particularly, the present invention relates to an electrospinning device,

The present invention relates to an electrospinning apparatus and a method of manufacturing a nanofiber mat using the electrospinning apparatus, and more particularly, to an electrospinning apparatus for manufacturing nanofibers including a drum collector and a method of manufacturing a nanofiber mat using the same.

In order to grow human tissues, for example muscles and nerves, which require directionality in the bio-field, nanofibers are arranged in one direction rather than non-woven nanofiber mat (or nanofiber membrane) in which nanofibers are randomly arranged A nanofiber mat including nanofibers (hereinafter referred to as a directional nanofiber mat) is more suitable. When the directional nanofiber mat is used for growth of neurons, the efficiency is high, and the muscle cells grown on the directional nanofiber mat are highly effective in the contraction / relaxation activity in the direction of alignment of the nanofibers.

A general electrospinning apparatus is an electrospinning apparatus including a drum collector rotated so as to accumulate nanofibers. The nanofibers are aligned in the rotating direction of the drum collector while the nanofibers are wound on the drum collector, thereby forming directional nanofibers. Although the electrospinning device including the drum collector effectively aligns the nanofibers, the tendency of the nanofibers to move linearly toward the drum collector due to the electric field between the nozzle and the drum collector, and to spread from the nozzle to the drum collector Or irregularly adhered thereto, there is a limit in accumulating nanofibers in a specific region of the drum collector. In addition, although an electrospinning device including a drum collector can easily manufacture a single-material nanofiber mat, it is difficult to introduce various kinds of nanofibers into the nanofiber mat.

SUMMARY OF THE INVENTION Accordingly, the present invention has been made in view of the above problems, and it is an object of the present invention to provide a nanofiber mat capable of controlling the integration area of nanofibers while aligning the nanofibers in one direction, And to provide an electrospinning device capable of introducing fibers.

Another object of the present invention is to provide a method for producing a multi-functional nanofiber mat using the electrospinning device.

According to an aspect of the present invention, there is provided an electrospinning device including a nozzle unit for injecting a polymer solution in one direction, a DC voltage applied to the nozzle unit, a polymer solution facing the nozzle unit, A DC voltage of a polarity opposite to that of the nozzle unit is applied to the drum unit, and a voltage of the same polarity as a DC voltage applied to the nozzle unit is applied between the nozzle unit and the drum collector, And a pair of side electrodes arranged to face each other in the extending direction.

In one embodiment, the nozzle portion may include at least two or more nozzles spaced from each other along the direction of extension of the axis of rotation of the drum collector. At this time, the nozzles may eject the same or different kinds of polymer solutions. Alternatively, the nozzles may discharge the polymer solution having the same or different concentration.

In one embodiment, the electrospinning device may further include a fixing unit fixing the distance between the nozzle unit and the side electrodes to be constant, and a transfer unit connected to the fixing unit to transfer the fixing unit.

According to another aspect of the present invention, there is provided a method of manufacturing a nanofiber mat, comprising: applying a first DC voltage to a nozzle unit for discharging a polymer solution; Applying a ground voltage to each of the pair of side electrodes, the pair of side electrodes being disposed between the nozzle unit and the drum collector and arranged to face each other in the direction of extension of the rotation axis of the drum collector, Second A step of applying a DC voltage, and a step of integrating the polymer solution discharged by the nozzle part with the drum collector to form nanofibers.

In one embodiment, the step of applying the second DC voltage may include increasing the second DC voltage to control the integration width of the nanofibers to be reduced.

In one embodiment, the step of forming the nanofibers may include controlling the transfer speed of the nozzle unit and the side electrodes.

In one embodiment, the nozzle portion includes at least two or more nozzles spaced apart from each other along the direction of extension of the axis of rotation of the drum collector, and each of the nozzles may have a different polymer solution or a polymer solution Can be discharged. At this time, the step of fabricating the nanofibers may include forming a nanofiber mat comprising a first pattern part in which first nanofibers are integrated and a second pattern part in which second nanofibers arranged in parallel to the first pattern part are integrated .

In one embodiment, the nanofiber mat may have the first and second pattern portions repeatedly arranged in one direction. The widths of the first pattern portion and the second pattern portion may be the same or different from each other depending on the electrical properties of the polymer forming the nanofibers of each of the first and second pattern portions, .

In one embodiment, before forming the first and second pattern portions, the method may further include forming a base layer integrated with the drum collector using a polymer solution.

In one embodiment, the concentration of the polymer solution discharged from the nozzle portion or the moving speed of the nozzle portion may be adjusted in the step of forming the nanofibers so that the nanofiber mat including pattern portions having different concentrations of the density or the functional material Can be produced. At this time, as the moving speed of the nozzle unit increases, the integrated density or the content of the functional compound may decrease along the moving direction of the nozzle unit in the nanofiber mat.

According to the electrospinning apparatus and the method of manufacturing the nanofiber mat using the electrospinning apparatus, the directional nanofiber mat is manufactured by aligning the nanofibers, and when the nanofibers are integrated in the drum collector, the nanofibers are prevented from spreading, It is possible to narrow the area to be integrated and to minimize the influence of the external environment.

In addition, it is possible to uniformly control the thickness of the nanofiber mat by designing to move in one direction with respect to the drum collector in a state where the nozzle and the side electrode are fixed in the spinning process.

In addition, it is possible to add and enhance the functionality of the nanofiber mat by preparing directional nanofiber mats having different materials and / or different densities for each position by controlling the integration position of the nanofibers in the drum collector. Accordingly, it can be easily used for selective permeation of nanofiber mat and control of gradient conditions to a cell growth environment.

1 is a conceptual diagram for explaining an electrospinning device including a drum collector according to an embodiment of the present invention.
2A is a conceptual diagram for explaining an electrospinning device including a drum collector according to another embodiment of the present invention.
FIG. 2B is a diagram for comparison with the electrospinning apparatus shown in FIG. 2A.
3A, 3B, 3C and 3D are plan views for explaining a nanofiber mat according to an embodiment of the present invention.
4 is a conceptual diagram illustrating an electrospinning device including a drum collector according to another embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. It is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, is intended to cover various modifications and similarities. It is to be understood, however, that the invention is not intended to be limited to the particular forms disclosed, but on the contrary, is intended to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.

The terms first, second, etc. may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another. For example, without departing from the scope of the present invention, the first component may be referred to as a second component, and similarly, the second component may also be referred to as a first component.

The terminology used in this application is used only to describe a specific embodiment and is not intended to limit the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In the present application, the term "comprises" or "having" is intended to designate the presence of stated features, elements, etc., and not one or more other features, It does not mean that there is none.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries are to be interpreted as having a meaning consistent with the contextual meaning of the related art and are to be interpreted as either ideal or overly formal in the sense of the present application Do not.

1 is a conceptual diagram for explaining an electrospinning device including a drum collector according to an embodiment of the present invention.

1, an electrospinning apparatus 101 includes a nozzle unit 110, a drum collector 120, and a pair of side electrodes 130a and 130b.

The nozzle unit 110 discharges the polymer solution 210. The polymer solution 210 is accommodated in a material supply unit (not shown) connected to the nozzle unit 110 and discharged toward the drum collector 120 through the nozzle unit 110. The material supply may include a microfluidic pump such as a syringe pump or the like.

The polymer solution 210 may include a non-absorbable synthetic polymer. Examples of the non-absorbable synthetic polymer include nylon, polyacrylic acid (PA), polyacrylonitrile, polyamind, poly (benzimidazole), PBI ), Polycarbonate, polyetherimide (PEI), poly (ethylene oxide), poly (ethylene terephthalate) (PET), polystyrene (PS) ), Polyethylene (PE), poly (styrene-butadiene-styrene) triblock copolymer, polysulfone, poly (triethylene terephthalate) triethyleneterephthalate), polyurethane, polyurethane (urethane), poly (vinyl alcohol), poly (vinyl carbazole), poly Poly (vinyl chloride), poly (vinylpyrrolidone) polyvinylidene fluoride (PVDF), poly (vinylidene fluoride-co-hexafluoropropylene), poly (vinylidene fluoride-co-hexafluoropropylene) P (VDF-HFP)). These may be used alone or in combination of two or more.

As another example, the polymer solution 210 may include a biodegradable polymer. Examples of the biodegradable polymer include acrylonitrile-butadiene-styrene copolymer (ABS), polylactic acid (PLA), DegraPol (abmedica, Italy), polycaprolactone (ε-caprolactone), PCL), polydioxanone (PDO), poly (glutacic acid), PGA, poly (lactide-co- glycolide) , PLGA), poly (lactide-co-epsilon -caprolactone), polyurethane, and the like. These may be used alone or in combination of two or more.

As another example, the polymer solution 210 may include a natural polymer. Examples of the natural polymers include Bombyx mori silk fibroin, Casein, Cellulose acetate, Chitosan, Collagen, Fibrinogen, Gelatin, Wheat gluten and the like. These may be used alone or in combination of two or more.

The nozzle unit 110 may be a coaxial double nozzle. At this time, the ordered nanofibers 220 having a core-shell structure can be manufactured using the polymers and the additional materials as described above. In the nanofiber 220 of the core-shell structure, the additional material may be a core, and the polymer may be a shell coated on the outside of the core. Alternatively, the polymer solution 210 in which the polymer and the additional material are mixed may be provided in the material supply unit, and the nozzle unit 110 may discharge the polymer solution 210 to form the nanofibers 220.

In addition, the polymer solution 210 may further include various functional materials. Examples of the functional material include a growth inducer such as BFGF and BMP-2, a differentiation inducer such as dexamethasone, ascorbic acid, beta-glycerol phosphate, trans retinoic acid, Or a living person such as heparin or fucoidan. These may be used alone or in combination of two or more.

The drum collector 120 is arranged to face the nozzle unit 110 and accumulates the polymer solution 210 discharged from the nozzle unit 110. The solvent is evaporated or volatilized in the process of discharging the polymer solution 210 toward the drum collector 120 so that the polymer in the polymer solution 210 is accumulated on the surface of the drum collector 120 to become the directional nanofibers 220. In the step of accumulating the polymer solution 210, a thin film formed of a polymer or metal may be wound on the drum collector 120, and the polymer solution 210 may be accumulated on the thin film.

The drum collector 120 accumulates the polymer solution 210 while rotating about the rotation axis, and becomes the aligned nanofibers, that is, the directional nanofibers 220 by the rotation of the drum collector 120. At this time, the directional nanofibers 220 may be integrated on the drum collector 120 in a strip shape. The aggregate of the directional nanofibers 220 becomes the nanofiber mat 230, 240, 250, 260 (see Figs. 3A to 3D). When the rotation axis extends along the first direction D1, the discharge direction of the polymer solution 210 in the nozzle unit 110 is a second direction D2 that intersects the first direction D1. For example, the first direction D1 and the second direction D2 may be perpendicular to each other.

For electrospinning of the aromatic nanofibers 220, the nozzle unit 110 is applied with the first voltage to charge the polymer solution 210 to the first polarity. At this time, the first voltage may be a DC voltage. At the same time, a ground voltage is applied to the drum collector 120. To this end, the electrospinning apparatus 101 may further include a high voltage power supply (not shown) for applying a voltage to the nozzle unit 110 and the drum collector 120.

As the voltage is applied to the nozzle unit 110 and the drum collector 120, an electric field is generated between the nozzle unit 110 and the drum collector 120, and the polymer solution 210 can be accumulated in the drum collector 120.

A pair of side electrodes 130a and 103b are disposed between the nozzle unit 110 and the drum collector 120. [ At this time, the pair of side electrodes 130a and 130b are disposed so as to face each other in a path through which the polymer solution 210 is discharged. Hereinafter, the side electrodes arranged on the first side of the drum collector 120 will be referred to as "first side electrodes 130a ", and the side electrodes arranged in the first direction D1 on the first side will be referred to as & Side electrode 130b ". The polymer solution 210 is discharged along the second direction D2 between the first and second side electrodes 130a and 103b.

The polymer solution 210 is discharged in the second direction D2 and the first and second side electrodes 130a and 130b are opposed to each other in the first direction D1 which is the extending direction of the rotation axis of the drum collector 120, . The distance between the first and second side electrodes 130a and 130b may be equal to or shorter than the length of the drum collector 120 in the first direction D1. Each of the first and second side electrodes 130a and 130b may be a plate electrode including a plane having a predetermined area and including the same direction as the second direction D2 in the in-plane direction. In this case, the diameter of each of the first and second side electrodes 130a and 130b may be about 1 cm to the diameter of the drum collector 120.

It is possible to control the integration area of the directional nanofibers 220 by adjusting the separation distance between the first and second side electrodes 130a and 130b. For example, the separation distance between the first and second side electrodes 130a and 130b may be narrowed to reduce the area where the directional nanofibers 220 are integrated.

A second voltage is applied to each of the first and second side electrodes 130a and 130b. At this time, the second voltage has the same polarity as the voltage applied to the nozzle unit 110. [ The second voltage may be a voltage equal to or similar to the first voltage. Since the voltage of the first polarity is applied to each of the first and second side electrodes 130a and 130b, the gap between the charged polymer solution 210 discharged from the nozzle unit 110 and the first side electrode 130a , A repulsive force is generated between the charged polymer solution 210 and the second side electrode 130b. The charged polymer solution 210 charged on the first and second side electrodes 130a and 130b can be converged on the central portion CA of the drum collector 120 and integrated.

The polymer solution 210 is supplied to the drum collector 120 while being irregularly moved or rotated instead of being discharged in a linear path from the nozzle unit 110 to the drum collector 120. Since the polymer solution 210 is accumulated in the drum collector 120 only by the electric field between the nozzle unit 110 and the drum collector 120 in the absence of the first and second side electrodes 130a and 130b, The area to be integrated in the memory 120 is very wide. That is, the polymer solution 210 is also accumulated in the center portion CA of the drum collector 120 and the first and second peripheral portions SA1 and SA2 which are both side regions of the center portion CA Reference). In other words, since the integration area of the polymer solution 210 can not be controlled in the past, the nanofiber mat produced by widely accumulating the polymer solution 210 in the drum collector 120 has a length almost equal to the length of the drum collector 120 It has a similar width and a non-uniform thickness, and also has a large amount of nanofibers. Particularly, the polymer solution 210 can be irregularly accumulated in the drum collector 120 due to the influence of an additional electric field generated by the surrounding environment of the conventional electrospinning device, for example, have.

On the other hand, the first and second side electrodes 130a and 130b of the electrospinning device 101 according to the present invention are disposed in the discharge path of the polymer solution 210 and the charged polarity of the polymer solution 210 Most of the polymer solution 210 is accumulated in the center portion CA of the drum collector 120 by applying a voltage of the same polarity. Accordingly, it is possible to stably integrate the polymer solution 210, narrowly control the width at which the directional nanofibers 220 are integrated, and adjust the width of the nanofiber mat, which is an aggregate of the directional nanofibers 220 .

Meanwhile, the alignment level of the directional nanofibers 220 can be controlled by controlling the linear velocity of the drum collector 120. As the linear velocity of the drum collector 120 increases, the degree of alignment of the directional nanofibers 220 increases and the directionality can be improved. For example, the linear velocity of the drum collector 120 may be 300 mm / s or more.

In addition, the integration width of the directional nanofibers 220 can be controlled by adjusting the second voltage applied to the first and second side electrodes 130a and 130b. As the second voltage increases, the integration width of the directional nanofibers 220 may decrease.

In order to form the nanofiber mat as the aggregate of the directional nanofibers 220 so as to have a relatively large area after forming the directional nanofibers 220 in a narrow region as described with reference to FIG. 1, 110 and the drum collector 120 may be transferred to accumulate the polymer solution 210. At this time, the distance between the nozzle unit 110 and the first and second side electrodes 130a and 130b must be maintained constant. When the nozzle unit 110 and the drum collector 120 are to be transferred, the nozzle unit 110 can continuously discharge the polymer solution 210.

The polymer solution 210 is accumulated while the nozzle unit 110 or the drum collector 120 is transported in the first direction D1 and then the nozzle unit 110 or the drum collector 120 is moved in the direction opposite to the first direction D1. The nanofiber mat may be obtained with a uniform thickness by integrating the polymer solution 210 while transferring the nanofiber mat 120.

When the nozzle unit 110 or the drum collector 120 is transported in the first direction D1, the directional nanofibers 220 may be accumulated in different thicknesses for each region of the drum collector 120 by controlling the feeding speed. . It is possible to relatively increase the transport speed in the region in which the directional nanofibers 220 are to be accumulated relatively and in the region where the directional nanofibers 220 are to be integrated in a thin state.

The directional nanofibers 220 can be stably formed by providing the first and second side electrodes 130a and 130b in the electrospinning device 101 and the directional nanofibers 220 The integration area can also be controlled.

2A is a conceptual diagram for explaining an electrospinning device including a drum collector according to another embodiment of the present invention.

2A, the electrospinning device 102 includes a nozzle unit 110, a drum collector 120, and first and second side electrodes 130a and 130b. The electrospinning apparatus 102 shown in FIG. 2A is substantially the same as the electrospinning apparatus 101 described in FIG. 1 except that the nozzle unit 110 includes a plurality of nozzles 112 and 114. Therefore, redundant detailed description will be omitted.

The nozzle unit 110 includes a first nozzle 112 and a second nozzle 114. The first nozzle 112 and the second nozzle 114 are arranged in a line in a first direction D1 which is the direction of extension of the rotation axis of the drum collector 120. [ A first side electrode 130a is disposed adjacent to the first nozzle 112 and a second side electrode 130b is disposed adjacent to the second nozzle 114. [ The first polymer solution 212 discharged by the first nozzle 112 and the second polymer solution 214 discharged by the second nozzle 114 are discharged through the first and second side electrodes 130a and 130b, . The first polymer solution 212 is accumulated in the drum collector 120 to become the first nanofiber 222 and the second polymer solution 214 is collected to become the second nanofiber 224. [

The polymers included in the first polymer solution 212 and the second polymer solution 214 may be independently substantially the same as the polymer of the polymer solution 210 described in FIG. Therefore, redundant detailed description will be omitted.

At this time, the polymer contained in the first polymer solution 212 may be of a different kind from the polymer contained in the second polymer solution 214. Accordingly, one nanofiber mat may contain nanofibers formed of at least two kinds of polymers.

The concentration of the first polymer solution 212 may be the same as the concentration of the second polymer solution 214. The concentration of the first polymer solution 212 may be the same as that of the second polymer solution 214, ≪ / RTI >

Alternatively, the first polymer solution 212 and the second polymer solution 214 may include the same polymer. In this case, when the nanofiber mat of the same size is formed, the nanofiber mat is manufactured in a relatively short time as compared with the case of including the single nozzle as in the electrospinning apparatus 101 described in FIG. 1, Can be shortened.

As described above, the nanofiber mat produced when the polymer types of the first and second polymer solutions 212 and 214 are different or have different concentrations will be described later with reference to FIGS. 3A to 3D.

Each of the first nozzle 112 and the second nozzle 114 receives a voltage having a first polarity and charges the first polymer solution 212 and the second polymer solution 214 with the first polarity. Referring to FIG. 2B, in which the first and second side electrodes 130a and 130b are absent, a repulsive force is generated between the first and second polymer solutions 212 and 214 charged with the first polarity, The distance between the first nanofibers 222 and the second nanofibers 224 in the drum collector 120 is much wider than the distance between the first and second nozzles 112 and 114. Further, it is very difficult to repeatedly spin the nanofibers to a specific position of the drum collector 120 due to repulsion between the first and second polymer solutions 212, 214. 2A, since the first polymer solution 212 and the second polymer solution 214 are affected by the repulsive force by the first and second side electrodes 130a and 130b, 2 polymer solution 212, 214, or the distance of the accumulation region between them can be minimized. That is, the first and second side surfaces 130a and 130b can repeatedly accumulate the first and second polymer solutions 212 and 214 at specific positions on the drum collector 120, respectively. Accordingly, the distance between the first nanofibers 222 and the second nanofibers 224 integrated in the drum collector 120 can be minimized. At the same time, the integration width of the first nanofiber 222 and the second nanofiber 224 can be controlled by the first and second side electrodes 130a and 130b.

According to the above description, the electrospinning apparatus 102 is provided with the first and second side electrodes 130a and 130b, and the nozzle unit 110 includes the two nozzles 112 and 114, The nanofibers 222 and the second nanofibers 224 can be stably formed and the integration area can be controlled to reduce the integration width. Also, the distance between the first nanofiber 222 and the second nanofiber 224 can be controlled.

In addition, since the first nanofibers 222 and the second nanofibers 224 can be formed simultaneously using the two nozzles 112 and 114, nanofibers of different materials can be formed on one nanofiber mat The nanofibers may be included at the same time, or nanofibers having different functions may be included at the same time. Alternatively, each of the two nozzles 112 and 114 may discharge the same polymer solution to shorten the time required to manufacture the nanofiber mat. Accordingly, the functionality of the nanofiber mat including the first and second nanofibers 222 and 224 can be improved, and the multifunctionality can be obtained.

At least one of the nozzle unit 110 and the drum collector 120 is transferred in the process of manufacturing the nanofiber mat including the first nanofiber 222 and the second nanofiber 224. At this time, when the nozzle unit 110 or the drum collector 120 is transferred at a value larger than the distance between the first and second nanofibers 222 and 224, the thickness of the nanofiber mat may be uniformed as a whole. Particularly, when the feeding distance of the nozzle unit 110 or the drum collector 120 is twice or more the distance between the first and second nozzles 112 and 114, a more uniform thickness of the nanofiber mat is manufactured .

Although the nozzle unit 110 includes two nozzles 112 and 114 in FIG. 2A, the number of nozzles included in the nozzle unit 110 is not limited to the number of nozzles included in the nozzle unit 110, And can be variously adjusted depending on the width and thickness of the nanofiber mat.

When the width of the nano fiber mat to be manufactured by the user is x, the nozzle unit 110 or the drum collector 120 is moved larger than a value obtained by dividing the width x by the distance y between the outermost nozzles It is possible to produce a nanofiber mat having a uniform thickness. For example, when the nozzle unit 110 includes n nozzles, the distance between the first nozzle and the nth nozzle may be greater than the value obtained by dividing the width of the nanofiber mat by the nozzle unit 110 or the drum The distance of movement of the collector 120 can be adjusted.

Hereinafter, a nanofiber mat manufactured when the nozzle unit 110 includes two or more nozzles will be described in detail with reference to FIGS. 3A to 3D.

3A, 3B, 3C and 3D are plan views for explaining a nanofiber mat according to an embodiment of the present invention.

3A, the nanofiber mat 230 includes a first pattern portion 232 and a second pattern portion 234. Referring to FIG. The nanofiber mat 230 has a structure in which the first and second pattern units 232 and 234 become one unit UT and are repeatedly arranged in one direction.

The first pattern unit 232 includes nanofibers formed of the first polymer solution 212 discharged through the first nozzle 122 described with reference to FIG. 2A. The second pattern unit 234 includes nanofibers formed of the second polymer solution 214 discharged through the second nozzle 124 described with reference to FIG. 2A. In this case, the polymer contained in the first polymer solution 212 may be of a different kind from the polymer contained in the second polymer solution 214.

A unit UT is formed by using the electrospinning apparatus 102 described with reference to FIG. 2A, and either the drum collector 120 or the nozzle unit 110 is moved in the first direction D1 Thereby forming one unit UT as a secondary unit. At this time, the nozzle unit 110 can be moved in a fixed state such that a relative distance between the first and second side electrodes 130a and 130b is kept constant. By repeating the process of forming the unit UT as described above, the nanofiber mat 230 having the structure in which the two pattern units 232 and 234 are repeatedly arranged can be manufactured.

Referring to FIG. 3B, the nanofiber mat 240 includes a first pattern portion 242, a second pattern portion 244, and a third pattern portion 246, and the first through third pattern portions 242, 244, and 246 are repeatedly arranged in one direction as one unit UT. At this time, the nozzle unit of the electrospinning apparatus for manufacturing the nanofiber mat 240 may include three nozzles in total, including one nozzle in addition to the two nozzles illustrated in FIG. 2A. A nanofiber mat 240 comprising three kinds of nanofibers can be manufactured by discharging polymer solutions each containing three different nozzles.

The nanofiber mats 230 and 240 described in FIGS. 3A and 3B can introduce nanofibers formed of different kinds of polymers into one nanofiber mat 230 and 240, 240), and the nanofiber mats 230, 240 may have versatility.

3C, the nanofiber mat 250 includes a base layer 252, a first pattern portion 254, a second pattern portion 256, and a third pattern portion 258 formed on the base layer 252 ).

The first to third pattern units 254, 256 and 258 may be formed of the same polymer and the base layer 252 may be formed of a different polymer. The base layer 252 is formed to have substantially the same size as the nanofiber mat 250 and the first to third pattern portions 254, 256 and 258 are partially formed in the base layer 252. The first to third pattern units 254, 256, and 258 may also be formed of different polymers. At this time, the widths of the first pattern portion and the second pattern portion may vary depending on the electrical properties of the polymer forming the nanofibers of the first and second pattern portions, for example, the insulation coefficient.

The base layer 252 and the first to third pattern portions 254, 256 and 258 are formed using the electrospinning apparatus 101 described in FIG. 1 and / or the electrospinning apparatus 102 described in FIG. . For example, the base layer 252 is formed using the electrospinning apparatus 101 shown in FIG. 1, and the first to third pattern units 254, 256, and 258 are formed by using the electrospinning apparatus 102). The width of each of the first to third pattern units 254, 256, and 258 can be adjusted by changing the amount of the solution discharged from the nozzles, the discharge time, and the like.

Referring to FIG. 3D, the nanofiber mat 260 includes a first pattern portion U1, a second pattern portion U2, a third pattern portion U3, an n-1 pattern portion Un-1, n pattern portions Un.

The integrated density of the nanofibers constituting each of the first to n-th pattern units U1, U2, U3, ..., Un-1, Un and / or the content of the functional material are different from each other. Accordingly, the nanofiber mat 260 may have a structure in which the density or the content of the functional compound gradually decreases from the first pattern portion U1 to the n-th pattern portion Un. The nanofiber mat 260 having the structure described in Fig. 3D can be manufactured by changing the feeding speed of the nozzle unit 110 or the drum collector 120. Fig. In order to form a pattern portion having a high integration density or a high functional material content, in order to reduce the transfer speed relatively and to form a pattern portion having a low integration density or a low functional material content, The density gradient and content can be controlled.

For example, the first nozzle 122 of the electrospinning apparatus 102 shown in Fig. 2A is caused to eject a first polymer solution mixed with a functional material such as a growth factor, and the second nozzle 124 is caused to eject the second polymer solution When the solution is to be discharged, the transfer speed is gradually increased in the first direction D1, and then the transfer speed is gradually increased again in the direction opposite to the first direction D1 after the primary accumulation .

Specifically, when the liquid is transported in the first direction D1, the first nozzle 122 discharges the first polymer solution and the second nozzle 124 does not discharge the second polymer solution. As a result, the patterning portions can be formed with a low integration density and a low content of the functional material while being transferred in the first direction D1. Next, when transferring in the opposite direction to the first direction D1, the first nozzle 122 does not discharge the first polymer solution and the second nozzle 124 can control to discharge the second polymer solution have. Accordingly, the conveying speed at the time of conveying in the direction opposite to the first direction D1 can be substantially the same as the conveying speed at the time of conveying in the first direction D1. Accordingly, the pattern portions can be formed which are gradually transferred in the direction opposite to the first direction D1 while having a low integration density. As a result, through the primary and secondary integration processes as described above, the nanofiber mat having the gradient that the aggregation density of the nanofibers as a whole is similar but the content of the functional material gradually decreases toward the first direction (D1) 260) can be produced.

The nanofiber mats 230, 240, 250, and 260 described in FIGS. 3A to 3D may be used in an unfolded state, and may be used by being rolled if necessary in the case of ligament, bone, and the like.

4 is a conceptual diagram for explaining an electrospinning device according to another embodiment of the present invention.

4, the electrospinning apparatus 103 includes a nozzle unit 110, a drum collector 120, first and second side electrodes 130a and 130b, a transfer unit 140, and a fixing unit 150 . The electrospinning apparatus 103 of FIG. 4 is substantially the same as the electrospinning apparatus 102 described in FIG. 2A, except that it further includes a feed section 140 and a fixing section 150. Therefore, redundant detailed description will be omitted and differences will be mainly described.

The transfer unit 140 is connected to the nozzle unit 110 and the first and second side electrodes 130a and 130b and the fixing unit 150 and is connected to the drum unit 120 in a first direction D1 ). At this time, it is preferable that the drum collector 120 is fixed at one position.

The fixing unit 150 is connected to the nozzle unit 110 and the first and second side electrodes 130a and 130b to fix the distance between the nozzle unit 110 and the first and second side electrodes 130a and 130b. The nozzle unit 110 and the first and second side electrodes 130a and 130b move in the first direction D1 when the fixing unit 150 moves in the first direction D1 by the transfer unit 140. [ Lt; / RTI >

As described above, by fixing the positions of the nozzle unit 110 and the first and second side electrodes 130a and 130b by the fixing unit 150 and transferring them using the transfer unit 140, After the fibers 222 and the second nanofibers 224 are integrated, the polymer solution is continuously accumulated to stably manufacture the nanofiber mats 230, 240, 250, and 260 as illustrated in FIGS. 3A to 3D . Therefore, the thickness of the nanofiber mats 230, 240, 250 and 260 can be made uniform, and the function of the nanofiber mat can be improved by adding two or more functions to one nanofiber mat.

The description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features presented herein.

101, 102, 103: electrospinning device
110: nozzle part
120: Drum collector
130a, 130b: first and second side electrodes
140:
150:
210: polymer solution
220, 230, 240, 250: Nano fiber mat

Claims (14)

A nozzle unit to which the polymer solution is discharged in one direction and to which a DC voltage is applied;
A drum collector configured to face the nozzle unit, to accumulate the polymer solution, to apply a ground voltage, and to rotate the drum collector; And
And a voltage of the same polarity as the DC voltage applied to the nozzle unit is simultaneously applied to the charged polymer solution while being discharged from the nozzle unit, And a pair of side electrodes arranged to face each other in the extending direction of the rotation axis of the collector.
The method according to claim 1,
The nozzle portion
And at least two or more nozzles spaced from each other along an extending direction of a rotational axis of the drum collector.
3. The method of claim 2,
Wherein the nozzles eject the same or different kinds of polymer solutions.
3. The method of claim 2,
Wherein the nozzles discharge the polymer solution of the same or different concentration.
The method according to claim 1,
A fixing unit fixing the distance between the nozzle unit and the side electrodes so as to be constant; And
And a transfer unit connected to the fixing unit to transfer the fixing unit.
Applying a first DC voltage to a nozzle unit for discharging the polymer solution;
Applying a ground voltage to a drum collector configured to rotate opposite to the nozzle portion;
And a pair of side electrodes disposed between the nozzle unit and the drum collector and arranged to face each other in the direction of extension of the rotation axis of the drum collector, Simultaneously applying the same second DC voltage having the same polarity as the first DC voltage; And
And collecting the polymer solution discharged from the nozzle portion while rotating the drum collector to form nanofibers.
A method for producing a nanofiber mat.
The method according to claim 6,
The step of applying the second DC voltage
And controlling the integration width of the nanofibers to be decreased by increasing the second DC voltage.
A method for producing a nanofiber mat.
The method according to claim 6,
The step of forming the nanofibers comprises:
And controlling the feeding speed of the nozzle unit and the side electrodes.
A method for producing a nanofiber mat.
The method according to claim 6,
The nozzle portion
And at least two or more nozzles spaced apart from each other along an extension direction of the rotation axis of the drum collector, wherein each of the nozzles ejects a different kind of polymer solution or a polymer solution having the same but different concentration,
The step of producing the nanofibers comprises
Wherein the nanofiber mat comprises a first pattern portion on which the first nanofibers are integrated and a second pattern portion on which the second nanofibers arranged in parallel to the first pattern portion are integrated.
A method for producing a nanofiber mat.
10. The method of claim 9,
The nanofiber mat
Wherein the first and second pattern units are repeatedly arranged in one direction.
A method for producing a nanofiber mat.
10. The method of claim 9,
Wherein a width of the first pattern portion and a width of the second pattern portion are the same or different from each other.
A method for producing a nanofiber mat.
10. The method of claim 9,
Further comprising the step of forming a base layer integrated with the drum collector using a polymer solution before forming the first and second pattern portions,
A method for producing a nanofiber mat.
The method according to claim 6,
In the step of forming the nanofibers
Wherein the density of the polymer solution discharged from the nozzle portion or the moving speed of the nozzle portion is adjusted to produce a nanofiber mat comprising pattern portions having different concentrations or different contents of functional materials.
A method for producing a nanofiber mat.
14. The method of claim 13,
Characterized in that the density or the content of the functional compound decreases along the moving direction of the nozzle part in the nanofiber mat as the moving speed of the nozzle part increases,
A method for producing a nanofiber mat.

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