Nothing Special   »   [go: up one dir, main page]

KR101270233B1 - Ventricular Partitioning Device - Google Patents

Ventricular Partitioning Device Download PDF

Info

Publication number
KR101270233B1
KR101270233B1 KR1020110005828A KR20110005828A KR101270233B1 KR 101270233 B1 KR101270233 B1 KR 101270233B1 KR 1020110005828 A KR1020110005828 A KR 1020110005828A KR 20110005828 A KR20110005828 A KR 20110005828A KR 101270233 B1 KR101270233 B1 KR 101270233B1
Authority
KR
South Korea
Prior art keywords
ventricular
ventricles
bag
compartment device
pocket
Prior art date
Application number
KR1020110005828A
Other languages
Korean (ko)
Other versions
KR20120084458A (en
Inventor
심은보
Original Assignee
강원대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 강원대학교산학협력단 filed Critical 강원대학교산학협력단
Priority to KR1020110005828A priority Critical patent/KR101270233B1/en
Priority to PCT/KR2012/000500 priority patent/WO2012099418A2/en
Publication of KR20120084458A publication Critical patent/KR20120084458A/en
Application granted granted Critical
Publication of KR101270233B1 publication Critical patent/KR101270233B1/en

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12027—Type of occlusion
    • A61B17/12036—Type of occlusion partial occlusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12177—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00—Dilators with or without means for introducing media, e.g. remedies
    • A61M29/02—Dilators made of swellable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2478—Passive devices for improving the function of the heart muscle, i.e. devices for reshaping the external surface of the heart, e.g. bags, strips or bands
    • A61F2/2487—Devices within the heart chamber, e.g. splints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having an inflatable pocket filled with fluid, e.g. liquid or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/16—Materials with shape-memory or superelastic properties

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • External Artificial Organs (AREA)
  • Prostheses (AREA)

Abstract

본 발명은 심부전(congestive heart failure) 환자의 치료와 관련된 것으로서, 더욱 상세하게는 심부전 환자의 심실을 구획하는 장치에 관한 것이다. 본 발명에 의하면, 캐뉼러는 통해서 이동할 수 있는 접힌 상태에서 심실을 가동부와 비가동부로 구획하는 펼친 상태로 팽창할 수 있는 주머니; 상기 주머니의 내면에 결합하며, 상기 주머니를 접힌 상태에서 펼친 상태로 변형시키는 팽창 와이어; 상기 주머니의 중심에 고정되며, 심실벽까지 연장되어, 심실벽에 안착하는 지지수단;을 구비하는 심실구획장치가 제공된다. 본 발명에 따른 심실구획장치는 심실을 가동부와 비가동부로 구획하여 심실의 부피와 심실에 가해지는 스트레스를 감소시킬 수 있다. 따라서 심부전 환자의 심장의 박출률을 증가시킬 수 있다. The present invention relates to the treatment of patients with congestive heart failure, and more particularly, to devices that partition the ventricles of heart failure patients. According to the present invention, the cannula includes a pocket that can be expanded in an expanded state to partition the ventricles into movable and non-movable portions in a folded state that can be moved through; An expansion wire coupled to an inner surface of the bag and deforming the bag in a folded state in a folded state; It is fixed to the center of the bag, extends to the ventricular wall, there is provided a ventricular compartment device comprising; a support means for seating on the ventricular wall. The ventricular compartment device according to the present invention can partition the ventricles into movable parts and non-movable parts to reduce the volume of the ventricles and the stress applied to the ventricles. Therefore, the cardiac ejection rate of heart failure patients can be increased.

Description

심실구획장치{Ventricular Partitioning Device}Ventricular Partitioning Device

본 발명은 심부전(congestive heart failure) 환자의 치료와 관련된 것으로서, 더욱 상세하게는 심부전 환자의 심실을 구획하는 장치에 관한 것이다. The present invention relates to the treatment of patients with congestive heart failure, and more particularly, to devices that partition the ventricles of heart failure patients.

심부전이란 심장의 구조적 또는 기능적 이상으로 인해 심장이 혈액을 받아들이는 충만 기능(이완 기능)이나 짜내는 펌프 기능(수축 기능)이 감소하여 신체 조직에 필요한 혈액을 제대로 공급하지 못해 발생하는 질환군을 말한다.Heart failure is a group of diseases caused by the heart's structural or functional abnormalities that result in a decrease in the heart's ability to receive blood (relaxation) or squeezing pumps (contraction), resulting in poor blood supply to body tissues. .

심부전은 심장, 특히, 좌심실의 점진적인 확장이 특징이다. 심장이 점점 확장됨에 따라, 심장은 심박을 통해서 혈액을 효과적으로 펌핑하기 어려워진다. Heart failure is characterized by gradual dilation of the heart, especially the left ventricle. As the heart expands, the heart becomes more difficult to pump blood efficiently through the heart beat.

심부전의 초기단계에는 약물 치료를 통해서 병의 진행을 늦출 수 있으나, 병을 고칠 수는 없다. 수술적 치료는 대개 약물 치료와 같은 내과적 치료에 잘 반응하지 않는 중증 심부전에서 제한적으로 사용되는 방법으로, 관상동맥 질환에 동반된 심부전에서의 관상동맥 우회술, 늘어난 심장을 잘라내고 용적을 줄여주는 수술, 심부전으로 인해 승모판주머니이 심각하게 새는 폐쇄 부전증이 있을 때 이를 교정하는 수술 등이 있으며, 바이러스성 급성 심근염과 같이 일정 시간을 견디면 소생할 가능성이 있는 중증 불응성 심부전이나 심장 이식을 기다리는 말기 심부전에서는 아예 기능이 떨어진 심장을 우회하는 고가의 보조적 장치(VAD, Ventricular Assistance Device)를 부착하여 시간을 벌기도 한다.In the early stages of heart failure, medication can slow the progression of the disease, but the disease cannot be cured. Surgical treatment is a limited use in severe heart failure that usually does not respond well to medical treatments such as medication. Coronary artery bypass surgery in heart failure associated with coronary artery disease, surgery to cut the enlarged heart and reduce volume These include surgery to correct when the mitral valve leaks severely due to heart failure.Severe refractory heart failure, such as viral acute myocarditis, that can survive if endured for a certain period of time. It is also possible to buy time by attaching expensive Ventricular Assistance Device (VAD) that bypasses the deficient heart.

심부전의 유일한 항구적인 치료방법은 심장 이식으로서, 최선의 내과적 치료에도 중증 심부전 환자의 연간 사망률이 30~50% 이상인데 비해, 면역 억제 치료의 발달 등으로 심장 이식 후 5년 생존율이 75% 이상임을 고려하면 이식 수술은 대상이 되는 말기 심부전 환자의 치료에 가장 우수한 치료법이라 할 수 있다. 그러나 제공자의 수가 필요한 경우보다 훨씬 적은 등의 문제로 널리 시행되는 데는 제한이 있다. The only permanent treatment for heart failure is heart transplantation. Even with the best medical treatment, the annual mortality rate of severe heart failure patients is 30-50% or more. Considering that the transplant surgery is the best treatment for the treatment of end-stage heart failure patients. However, there are limitations to the widespread implementation of such problems as the number of providers is much smaller than necessary.

본 발명은 상술한 문제점을 해결하기 위한 것으로서, 심실을 가동부와 비가동부로 구획하여 심실의 부피와 심실에 가해지는 스트레스를 감소시켜 심장의 박출률(ejection fraction)을 증가시킬 수 있는 심실구획장치를 제공하는 것을 목적으로 한다. The present invention is to solve the above-described problems, the ventricular compartment is divided into a movable part and a non-moving part ventricular compartment device that can increase the ejection fraction of the heart by reducing the volume of the ventricles and stress on the ventricles It aims to provide.

본 발명에 의하면, 캐뉼러는 통해서 이동할 수 있는 접힌 상태에서 심실을 가동부와 비가동부로 구획하는 펼친 상태로 팽창할 수 있는 주머니; 상기 주머니의 내면에 결합하며, 상기 주머니를 접힌 상태에서 펼친 상태로 변형시키는 팽창 와이어; 상기 주머니의 중심에 고정되며, 심실벽까지 연장되어, 심실벽에 안착하는 지지수단;을 구비하는 심실구획장치가 제공된다. According to the present invention, the cannula includes a pocket that can be expanded in an expanded state to partition the ventricles into movable and non-movable portions in a folded state that can be moved through; An expansion wire coupled to an inner surface of the bag and deforming the bag in a folded state in a folded state; It is fixed to the center of the bag, extends to the ventricular wall, there is provided a ventricular compartment device comprising; a support means for seating on the ventricular wall.

심실벽과 접하는 상기 주머니의 외주면에는 심실벽에 삽입되어 고정될 수 있도록 날카로운 선단 요소가 구비되는 것이 바람직하다. The outer peripheral surface of the bag in contact with the ventricular wall is preferably provided with a sharp tip element to be inserted and fixed in the ventricular wall.

상기 주머니는 폴리테트라플루오로에틸렌(ePTFE; expanded Polytetrafluoroethylene), 나일론(Nylon), PET(polyethylene terephthalate), 폴리에스테르 중에서 선택된 생체적합성 고분자물질인 것이 바람직하다.Preferably, the bag is a biocompatible polymer selected from polytetrafluoroethylene (ePTFE), expanded polytetrafluoroethylene (NPT), nylon (Nylon), polyethylene terephthalate (PET), and polyester.

상기 팽창 와이어는 형상기억합금 또는 형상기억고분자로 이루어지거나, 탄성이 있는 재질로 이루어지며 상기 주머니가 펼쳐지는 방향으로 탄성을 제공하는 것이 바람직하다. The expansion wire is made of a shape memory alloy or a shape memory polymer, or made of an elastic material and preferably provides elasticity in the direction in which the bag is unfolded.

상기 팽창 와이어에는 심실구획장치를 심실 내에 배치하는 과정에서 그 위치를 찾는 것이 용이하도록, 초음파, X선 등으로 위치를 확인할 수 있는 마커를 더 포함하는 것이 바람직하다. Preferably, the expansion wire further includes a marker that can identify the position by ultrasound, X-ray, or the like, so that the position of the ventricular compartment in the ventricle is easily located.

상기 지지수단은, 일정한 각도로 벌어지는 3개의 원기둥형태인 것이 바람직하다.It is preferable that the said support means are three cylindrical forms which open at a fixed angle.

본 발명에 따른 심실구획장치는 심실을 가동부와 비가동부로 구획하여 심실의 부피와 심실에 가해지는 스트레스를 감소시킬 수 있다. 따라서 심부전 환자의 심장의 박출률을 증가시킬 수 있다. The ventricular compartment device according to the present invention can partition the ventricles into movable parts and non-movable parts to reduce the volume of the ventricles and the stress applied to the ventricles. Therefore, the cardiac ejection rate of heart failure patients can be increased.

도 1은 본 발명의 일실시예에 따른 심실구획장치의 사시도이다.
도 2는 도 1에 도시된 심실구획장치가 접혀있는 상태를 나타내는 사시도이다.
도 3은 도 1에 도시된 심실구획장치가 심실에 안착된 상태를 나타내는 개략도이다.1 is a perspective view of a ventricular compartment device according to an embodiment of the present invention.
Figure 2 is a perspective view showing a state in which the ventricular compartment device shown in Figure 1 is folded.
Figure 3 is a schematic diagram showing a state in which the ventricular compartment device shown in Figure 1 is seated in the ventricles.

이하, 첨부된 도면들을 참고하여 본 발명의 일실시예를 상세히 설명하기로 한다. 그러나 본 발명의 실시예는 여러 가지 다른 형태들로 변형될 수 있으며, 본 발명의 범위가 아래에서 상술하는 실시예로 한정되는 것으로 해석되어서는 안 된다. 본 발명의 실시예는 당업계에서 평균적인 지식을 가진 자에게 본 발명을 더욱 완전하게 설명하기 위하여 제공되는 것이다. 따라서 도면에서의 요소의 형상 등은 더욱 명확한 설명을 강조하기 위해서 과장된 것이며, 도면상에서 동일한 부호로 표시된 요소는 동일한 요소를 의미한다.Hereinafter, an embodiment of the present invention will be described in detail with reference to the accompanying drawings. However, embodiments of the present invention may be modified in many different forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. Embodiments of the present invention are provided to more fully describe the present invention to those skilled in the art. Therefore, the shape and the like of the elements in the drawings are exaggerated in order to emphasize more clear description, the elements denoted by the same reference numerals in the drawings means the same elements.

도 1은 본 발명의 일실시예에 따른 심실구획장치의 사시도이며, 도 2는 도 1에 도시된 심실구획장치가 접혀있는 상태를 나타내는 사시도이며, 도 3은 도 1에 도시된 심실구획장치가 심실에 안착된 상태를 나타내는 개략도이다. 심실구획장치는 도 2에 도시된 바와 같이 접힌 상태로 카테터를 통해서 심실에 전달된 후 도 1과 도 3에 도시된 바와 같이 펼쳐져서 심실을 가동부와 비가동부로 구획하게 된다. 심실구획장치가 설치된 후 비가동부는 처음에는 혈전에 의해서 충전되며, 이후에는 세포 성장으로 충전된다. 폴리 유산, 폴리 글리콜 산, 폴리카프로락톤 등 생체 재흡수성 충전재가 비가동부를 충전하기 위해 사용될 수도 있다. 1 is a perspective view of a ventricular compartment device according to an embodiment of the present invention, FIG. 2 is a perspective view showing a folded ventricular compartment device shown in FIG. 1, and FIG. 3 is a ventricular compartment device shown in FIG. 1. Schematic diagram showing the state of rest in the ventricles. The ventricular compartment device is delivered to the ventricle through the catheter in a folded state as shown in FIG. 2 and then expanded as shown in FIGS. 1 and 3 to divide the ventricle into a movable part and a non-moving part. After the ventricular compartment is installed, the non-moving part is initially filled by a thrombus and then by cell growth. Bioresorbable fillers such as polylactic acid, polyglycolic acid, polycaprolactone, etc. may be used to fill the non-movable parts.

도 1과 2를 참고하면, 본 발명의 일실시예에 따른 심실구획장치는 심실을 가동부와 비가동부로 구획하는 주머니(10), 주머니(10)를 팽창시키는 팽창 와이어(20), 주머니(10)에서 연장된 지지수단(30)을 구비한다. 1 and 2, the ventricular compartment device according to an embodiment of the present invention is a pocket 10 for dividing the ventricle into a movable part and a non-moving part, an expansion wire 20 to expand the pocket 10, a pocket 10 It has a support means (30) extending from).

주머니(10)는 생체 적합성이 있는 폴리머로서 예를 들면, 폴리테트라플루오로에틸렌(ePTFE; expanded Polytetrafluoroethylene), 나일론(Nylon), PET(polyethylene terephthalate), 폴리에스테르 등을 사용할 수 있다. 주머니(10)는 카테터를 통해서 심실에 전달되기 전까지는 접혀있는 상태로 보관되며, 심실에 전달되면 펼쳐져 심실을 구획한다. 주머니(10)의 중심부 둘레에는 심실벽에 삽입되어 고정될 수 있도록 날카로운 선단 요소(11)가 결합한다. 주머니(10)의 중심부 하단은 지지수단(30)에 고정된다. As the biocompatible polymer, the bag 10 may be, for example, expanded polytetrafluoroethylene (ePTFE), nylon (Nylon), polyethylene terephthalate (PET), polyester, or the like. The pocket 10 is stored in a folded state until it is delivered to the ventricles through the catheter, and is expanded to partition the ventricles when delivered to the ventricles. A sharp tip element 11 engages around the central portion of the pocket 10 so that it can be inserted into and fixed to the ventricular wall. The central lower end of the pocket 10 is fixed to the support means 30.

팽창 와이어(20)는 주머니(10)를 팽창시키기 위한 것이다. 팽창 와이어(20)는 주머니(10)의 내측에 결합한다. 팽창 와이어(20)가 팽창할 때 팽창 와이어(20)는 원형을 이루게 된다. 주머니(10)에서 팽창 와이어(20)가 결합된 부분은 주머니(10)에서 가장 단면적이 넓은 부분으로서, 심실구획장치가 심실에 안착할 때 심실벽에 접하는 부분이 된다. 이 부분에 상술한 선단 요소(11)도 결합한다. 팽창 와이어(20)는 형상기억합금 또는 형상기억고분자인 것이 바람직하다. 기억된 형상은 심실을 구획하기 용이하도록 주머니(10)을 펼치기 위해서 요구되는 형상으로서, 본 실시예에서는 원형이다. 형상기억합금 또는 형상기억고분자는 사람의 심장 온도이상의 온도에서는 기억되어 있는 이상적인 상태로 회복된다. 팽창 와이어(20)를 탄성이 있는 금속으로 제조하여, 심실구획장치가 카테터에서 분리될 때에 펼쳐지도록 할 수도 있다. The inflation wire 20 is for inflating the pocket 10. Expansion wire 20 is coupled to the inside of the pocket (10). When the inflation wire 20 expands, the inflation wire 20 is circular. The portion of the bag 10 to which the expansion wire 20 is coupled is the portion of the bag 10 having the widest cross-sectional area, and the part of the bag 10 is in contact with the ventricular wall when the ventricular compartment is seated in the ventricle. The tip element 11 described above is also coupled to this portion. The expansion wire 20 is preferably a shape memory alloy or shape memory polymer. The stored shape is a shape required for unfolding the bag 10 so as to easily partition the ventricles, and is circular in this embodiment. Shape memory alloys or shape memory polymers are restored to the ideal state stored at temperatures above the human heart temperature. The expansion wire 20 may be made of a resilient metal so that the ventricular compartment may expand when it is detached from the catheter.

팽창 와이어(20)에는 심실내에 심실구획장치를 배치하는 과정에서 그 위치를 찾는 것을 돕기 위해, 초음파, X-선 등으로 위치를 확인할 수 있는 마커가 설치될 수 있다. 마커로는 스테인리스강, 백금, 이리듐, 탄탈, 텅스텐, 은, 로듐, 니켈, 비스무스 등을 사용할 수 있다. The expansion wire 20 may be provided with a marker for identifying the position by ultrasound, X-ray, or the like to help locate the position in the process of placing the ventricular compartment in the ventricles. As the marker, stainless steel, platinum, iridium, tantalum, tungsten, silver, rhodium, nickel, bismuth or the like can be used.

지지수단(30)은 주머니(10)에서 연장된다. 지지수단(30)은 심실벽에 안착하여 주머니(10) 둘레의 선단 요소(11)들과 함께 심실구획장치를 심실벽에 고정하는 역할을 한다. 지지수단(30)은 심실구획장치를 심실에 전달하는 카테터에 접혀서 삽입될 수 있도록 유연한 재질로 이루어진다. 지지수단(30)은 다양한 형태가 가능하나 본 실시예에서는 일정한 각도로 벌어지는 3개의 원기둥형태의 지지수단(30)을 사용한다. The support means 30 extend from the pocket 10. The support means 30 seats on the ventricular wall and serves to secure the ventricular compartment device to the ventricular wall with the leading elements 11 around the pocket 10. The support means 30 is made of a flexible material so that it can be folded and inserted into the catheter that delivers the ventricular compartment device to the ventricles. The support means 30 may be in various forms, but in the present embodiment, three support means 30 having a cylindrical shape are opened at a predetermined angle.

이하, 상술한 구성을 가진 심실구획장치의 작용을 설명한다. Hereinafter, the operation of the ventricular compartment device having the above-described configuration will be described.

심실구획장치의 주머니(10)과 팽창 와이어(20) 및 지지수단(30)을 도 2에 도시된 바와 같이 접어서 카테터에 삽입한다. 심실구획장치가 삽입된 카테터를 종래의 방법을 이용하여 환자의 신체에 도입한다. 카테터가 심실에 도달하면, 심실구획장치를 카테터에서 분리시킨다. 카테터에서 분리된 심실구획장치의 팽창 와이어(20)는 기억된 형상으로 변형되어 심실구획장치의 주머니(10)을 펼친다. 지지수단(30)인 3개의 원기둥도 펼쳐지면서 심실에 안착한다. 펼쳐진 주머니(10)는 심실을 가동부와 비가동부로 구획한다. 심실구획장치는 주머니(10) 둘레의 선단 요소(11)와 지지수단(30)에 의해서 심실에 안착된다. 심실구획장치가 안착되면 심실의 비가동부는 처음에는 혈전에 의해서 충전되며, 이후에는 세포 성장으로 충전된다. 그 결과 심실의 부피와 심실에 가해지는 스트레스가 감소하고, 심부전 환자의 심장 박출률이 증가한다. The pocket 10, the expansion wire 20, and the support means 30 of the ventricular compartment device are folded and inserted into the catheter as shown in FIG. The catheter into which the ventricular compartment device is inserted is introduced into the patient's body using a conventional method. When the catheter reaches the ventricle, the ventricular compartment is detached from the catheter. The expansion wire 20 of the ventricular compartment device separated from the catheter is deformed into a memorized shape to unfold the pocket 10 of the ventricular compartment device. Three cylinders, which are the support means 30, also spread out and rest on the ventricles. The unfolded pocket 10 partitions the ventricles into movable and non-moving portions. The ventricular compartment device is seated in the ventricle by the tip element 11 and the support means 30 around the pouch 10. When the ventricular compartment is seated, the non-moving part of the ventricle is initially filled by a thrombus and then by cell growth. The result is a decrease in ventricular volume and stress on the ventricles, and an increase in cardiac ejection rates in heart failure patients.

이상에서 설명된 실시예는 본 발명의 바람직한 실시예를 설명한 것에 불과하고, 본 발명의 권리범위는 설명된 실시예에 한정되는 것은 아니며, 본 발명의 기술적 사상과 특허청구범위 내에서 이 분야의 당업자에 의하여 다양한 변경, 변형 또는 치환이 가능할 것이며, 그와 같은 실시예들은 본 발명의 범위에 속하는 것으로 이해되어야 한다. The embodiments described above are merely illustrative of the preferred embodiments of the present invention, the scope of the present invention is not limited to the described embodiments, those skilled in the art within the spirit and claims of the present invention It will be understood that various changes, modifications, or substitutions may be made thereto, and such embodiments are to be understood as being within the scope of the present invention.

주머니: 10 선단 요소: 11
팽창 와이어: 20 지지수단: 30 Pocket: 10 Tip element: 11
Expansion wire: 20 Supports: 30

Claims (7)

캐뉼러는 통해서 이동할 수 있는 접힌 상태에서 심실을 가동부와 비가동부로 구획하는 펼친 상태로 팽창할 수 있는 주머니;
상기 주머니의 내면에 결합하며, 상기 주머니를 접힌 상태에서 펼친 상태로 변형시키는 팽창 와이어;
상기 주머니의 중심에 고정되며, 심실벽까지 연장되어, 심실벽에 안착하는 지지수단;을 구비하며,
상기 팽창 와이어는 형상기억합금 또는 형상기억고분자로 이루어진 것을 특징으로 하는 심실구획장치. The cannula includes a pocket that can be expanded in an expanded state to partition the ventricles into movable and non-movable portions in a folded state that can be moved through;
An expansion wire coupled to an inner surface of the bag and deforming the bag in a folded state in a folded state;
It is fixed to the center of the pocket, extends to the ventricular wall, the support means for seating on the ventricular wall;
The expansion wire is a ventricular compartment device, characterized in that consisting of shape memory alloy or shape memory polymer. 제1항에 있어서,
심실벽과 접하는 상기 주머니의 외주면에는 심실벽에 삽입되어 고정될 수 있도록 날카로운 선단 요소가 구비되는 것을 특징으로 하는 심실구획장치. The method of claim 1,
Ventricular compartment device, characterized in that the outer peripheral surface of the pocket in contact with the ventricular wall is provided with a sharp tip element to be inserted and fixed to the ventricular wall. 제1항에 있어서,
상기 주머니는 폴리테트라플루오로에틸렌(ePTFE; expanded Polytetrafluoroethylene), 나일론(Nylon), PET(polyethylene terephthalate), 폴리에스테르 중에서 선택된 생체적합성 고분자물질인 것을 특징으로 하는 심실구획장치.The method of claim 1,
The bag is a ventricular compartment device, characterized in that the biocompatible polymer material selected from polytetrafluoroethylene (ePTFE; expanded Polytetrafluoroethylene), nylon (Nylon), PET (polyethylene terephthalate), polyester. 삭제delete 삭제delete 제1항에 있어서,
상기 팽창 와이어에는 심실구획장치를 심실 내에 배치하는 과정에서 그 위치를 찾는 것이 용이하도록, 초음파, X선 등으로 위치를 확인할 수 있는 마커를 더 포함하는 것을 특징으로 하는 심실구획장치. The method of claim 1,
The expansion wire further comprises a marker for identifying the position by ultrasound, X-ray, etc., so that the position is easy to find the position in the process of placing the ventricular compartment in the ventricles. 제1항에 있어서,
상기 지지수단은, 일정한 각도로 벌어지는 3개의 원기둥형태인 것을 특징으로 하는 심실구획장치.




The method of claim 1,
The support means is a ventricular compartment device, characterized in that three cylindrical forms that are opened at a predetermined angle.




KR1020110005828A 2011-01-20 2011-01-20 Ventricular Partitioning Device KR101270233B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020110005828A KR101270233B1 (en) 2011-01-20 2011-01-20 Ventricular Partitioning Device
PCT/KR2012/000500 WO2012099418A2 (en) 2011-01-20 2012-01-19 Ventricular partitioning device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020110005828A KR101270233B1 (en) 2011-01-20 2011-01-20 Ventricular Partitioning Device

Publications (2)

Publication Number Publication Date
KR20120084458A KR20120084458A (en) 2012-07-30
KR101270233B1 true KR101270233B1 (en) 2013-05-31

Family

ID=46516251

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020110005828A KR101270233B1 (en) 2011-01-20 2011-01-20 Ventricular Partitioning Device

Country Status (2)

Country Link
KR (1) KR101270233B1 (en)
WO (1) WO2012099418A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9694121B2 (en) 1999-08-09 2017-07-04 Cardiokinetix, Inc. Systems and methods for improving cardiac function
US10307147B2 (en) 1999-08-09 2019-06-04 Edwards Lifesciences Corporation System for improving cardiac function by sealing a partitioning membrane within a ventricle
US10064696B2 (en) 2000-08-09 2018-09-04 Edwards Lifesciences Corporation Devices and methods for delivering an endocardial device
US9332992B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Method for making a laminar ventricular partitioning device
US9332993B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
WO2016048802A1 (en) 2014-09-28 2016-03-31 Cardiokinetix, Inc. Apparatuses for treating cardiac dysfunction
US10555814B2 (en) 2015-11-17 2020-02-11 Edwards Lifesciences Corporation Ultrasound probe for cardiac treatment
DE102018107407A1 (en) 2017-03-28 2018-10-04 Edwards Lifesciences Corporation POSITIONING, INSERTING AND RETRIEVING IMPLANTABLE DEVICES

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050197716A1 (en) * 2004-03-03 2005-09-08 Cardiokinetix, Inc. Inflatable ventricular partitioning device
US20060281965A1 (en) 2005-06-10 2006-12-14 Alexander Khairkhahan Peripheral seal for a ventricular partitioning device
US20060293739A1 (en) 2005-03-02 2006-12-28 Venkataramana Vijay Cardiac Ventricular Geometry Restoration Device and Treatment for Heart Failure
US20100262168A1 (en) * 1999-08-09 2010-10-14 Alexander Khairkhahan Sealing and filling ventricular partitioning devices to improve cardiac function

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101070811B1 (en) * 2011-02-18 2011-10-06 강원대학교산학협력단 Ventricular partitioning device
KR101070809B1 (en) * 2011-02-21 2011-10-06 강원대학교산학협력단 Ventricular partitioning device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100262168A1 (en) * 1999-08-09 2010-10-14 Alexander Khairkhahan Sealing and filling ventricular partitioning devices to improve cardiac function
US20050197716A1 (en) * 2004-03-03 2005-09-08 Cardiokinetix, Inc. Inflatable ventricular partitioning device
US20060293739A1 (en) 2005-03-02 2006-12-28 Venkataramana Vijay Cardiac Ventricular Geometry Restoration Device and Treatment for Heart Failure
US20060281965A1 (en) 2005-06-10 2006-12-14 Alexander Khairkhahan Peripheral seal for a ventricular partitioning device

Also Published As

Publication number Publication date
WO2012099418A2 (en) 2012-07-26
KR20120084458A (en) 2012-07-30
WO2012099418A3 (en) 2012-12-06

Similar Documents

Publication Publication Date Title
KR101270233B1 (en) Ventricular Partitioning Device
JP4964235B2 (en) Perimeter seal for ventricular compartment device
KR101070811B1 (en) Ventricular partitioning device
JP4929172B2 (en) Ventricular divider
JP4519858B2 (en) Ventricular compartment
CN106573090B (en) Heart support device
ES2384081T3 (en) Valve with delayed flexible lamella deployment
JP5313928B2 (en) Percutaneous valves and systems
WO2018059178A1 (en) Partial left ventriculectomy device
US20110264204A1 (en) Devices and methods for delivering an endocardial device
JP2009504255A (en) How to treat myocardial rupture
JP6946030B2 (en) Distributed irrigation geometry for catheter tip design
US20120226340A1 (en) Temporary perfusion channel for percutaneous delivery of balloon-expandable stents
JP2012523267A (en) Sealed filling ventricular divider for improving cardiac function
JP2008545510A (en) Multiple compartment devices for cardiac therapy
JP7013591B2 (en) Closure device with expandable members
JP2016524937A (en) Intra-aortic balloon device, auxiliary device and method for improving blood flow, counter pulsation and hemodynamics
KR20170066470A (en) Apparatuses for treating cardiac dysfunction
CN102949253A (en) Support valve and conveying device thereof
WO2011117566A1 (en) Pulsatile blood pump
KR101270235B1 (en) Ventricular Partitioning Device
KR101070809B1 (en) Ventricular partitioning device
KR101270234B1 (en) Ventricular Partitioning Device
CN218075358U (en) Support structure
CN113348012B (en) Medical cavity system, introducing system and kit

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20160324

Year of fee payment: 4

LAPS Lapse due to unpaid annual fee