KR101221734B1 - Cosmetic composition of multi-pore patch for skin improvement of two-form type using lyophilization - Google Patents

Abstract

The present invention relates to a two-part porous skin improvement cosmetic composition prepared by the lyophilization method, and more particularly, it contains a component that promotes the absorption of the skin-active active ingredient into the skin and can dissolve the following two agents when used. By preparing a two-part skin improvement cosmetic composition consisting of two agents prepared in the form of a porous patch by lyophilizing a moisture gel cosmetic composition comprising a powder and an active ingredient for skin treatment without heating, further improving the stability of the active ingredient for skin care and skin It has excellent applicability to the product and is dissolved by the moisture of the skin after application of the product, so that it can be easily applied to the deep wrinkles, curved surfaces, and the hair part of the skin. It relates to a two-form porous skin improvement cosmetic composition.

Freeze drying, collagen, hyaluronic acid, moisture gel, skin improvement, stability

Description

Cosmetic composition of multi-pore patch for skin improvement of two-form type using lyophilization

The present invention relates to a two-part porous skin improvement cosmetic composition prepared by the lyophilization method, and more particularly, it contains a component that promotes the absorption of the skin-active active ingredient into the skin and can dissolve the following two agents when used. By preparing a two-part skin improvement cosmetic composition consisting of two agents prepared in the form of a porous patch by lyophilizing a moisture gel cosmetic composition comprising a powder and an active ingredient for skin treatment without heating, further improving the stability of the active ingredient for skin care and skin It has excellent applicability to the product and is dissolved by the moisture of the skin after application of the product, so that it can be easily applied to the deep wrinkles, curved surfaces, and the hair part of the skin. It relates to a two-form porous skin improvement cosmetic composition.

Vitamins, antioxidants and the like have been known as various physiological effects such as skin whitening, wrinkle improvement, skin elasticity and harmful oxygen removal, and have been used as active ingredients in cosmetics or dermatological medicines. However, these active ingredients are easily oxidized and destroyed when exposed to light or air, so their use has been limited. The destruction reaction by oxidation proceeds particularly rapidly when these active ingredients are in aqueous solution or in contact with water.

Methods for stabilizing these active ingredients by minimizing contact between the active ingredients and water are conventionally disclosed in Japanese Patent Application Laid-Open No. 63-130514, which formulates the active ingredients in the form of dry powder, US Pat. No. 4,818,512. After packaging the powdered active ingredient and the emulsified cosmetic liquid in each of the two containers, a method of mixing and using immediately before use by the consumer, U.S. Patent No. 5,322,683 discloses a method of forming anhydrous to not contain water, but these The method has the advantage that the stability of the active ingredient is maintained to some extent, but the formulation is limited to powder, the mixing is cumbersome, the packaging is expensive, or the feeling of oil is not good due to excessive oily feeling during application of the skin, especially to the water-soluble active ingredient. It has the disadvantage of being difficult to apply.

In general, those made from film formulations are much more soluble than powder formulations. This is because, in the case of film formulations, an active ingredient exists between a network of highly soluble hydrophilic polymers, so that caking or blocking phenomenon is much less than that of powder formulations.

On the other hand, Korean Patent Application No. 2007-0119930 discloses a lyophilized composition containing taxane derivatives with improved rehydration time and a method for preparing the same, wherein the composition is squeezed from water-soluble polymers containing saccharide and sugars using lyophilization. It is possible to shorten the time required for rehydration by preparing a topical freeze-drying method, but it is limited to dissolving it in water and using it as an injection, which is not suitable for applying as a patch for skin because it cannot maintain its form when applied as a patch. Do.

In addition, the Republic of Korea Patent Registration No. 10-0676937 discloses a hydrophilic film for skin care and wound treatment, which is a system in which the active ingredient is delivered into the transdermal while slowly dissolving due to a small amount of moisture when affixed to the skin. However, when the film is affixed to the skin, it is difficult to apply to the curved surface of the skin because the film dissolves with a small amount of water to induce adhesion with the skin, and it is a formulation having a weight of a conventional patch, and thus the adhesion strength is decreased when the film is adhered for a long time. There is a disadvantage that can be separated from the skin.

In order to overcome the drawbacks described above, the inventors of the present invention have been researched to provide a system that ensures stability and maintains activity during long-term storage as a system capable of delivering the skin-effect active ingredient to the skin more effectively. A two-part active ingredient skin comprising one agent prepared by supporting a water-soluble film in anhydrous film, and a second agent containing a component that promotes the absorption of the skin-active active ingredient into the skin and which can dissolve the first agent in use. By manufacturing the system, the stability of the active ingredient is secured, the applicability to the skin is excellent, and it is possible to reshape after applying the product so that it can be easily applied to deep wrinkles, curved surfaces as well as to the hair part of the skin. To provide a two-part active ingredient skin delivery system that does not deviate from Korean patent application No. 2008-0007535 has been applied for a patent.

The present inventor further goes to study to provide a cosmetic composition that can further improve the stability of the skin-cosmetic active ingredient than the two-component active ingredient skin delivery system contains a component that promotes the absorption of the skin-effect active ingredient into the skin. When using, prepare a two-part skin improvement cosmetic composition consisting of a first agent that can dissolve the following two agents and a water gel cosmetic composition comprising an active ingredient for skin care, freeze-dried without a heating process to prepare a two-component skin composition in the form of a porous patch. It further improves the stability of beauty active ingredients, has excellent applicability to the skin, and is dissolved by the moisture of the skin after the application of the product, so that it can be easily applied to deep wrinkles, curved surfaces, as well as to the hair part of the skin. Two-component porous skin improvement cosmetic preparation prepared by lyophilization method The present invention has been completed by confirming that the sacrificial material can be provided.

Accordingly, an object of the present invention is to prepare a patch formulation by lyophilizing a composition containing a component that promotes absorption of the skin-effective active ingredient and capable of dissolving the following two agents when used, and a composition comprising the skin-effective active ingredient without heating. It is to provide a skin improvement cosmetic composition consisting of a porous patch 2 agent.

In one embodiment, the present invention is a lyophilized composition comprising a component that promotes the absorption of the skin-effect active ingredient into the skin and which can dissolve the following two agents when used, and a composition containing the skin-effect active ingredient by anhydrous It provides a two-part skin improvement cosmetic composition comprising a porous patch 2 formulated with a lyophilized patch of.

As another aspect, the present invention is a lyophilized composition comprising a component that promotes the absorption of the skin-effect active ingredient into the skin and can dissolve the following two agents when used, and a composition comprising the skin-effect active ingredient Provided is a skin improvement cosmetic kit comprising a porous patch 2 formulated with anhydrous lyophilized patches.

As another aspect, the present invention comprises a skin-cosmetic active ingredient containing a component that promotes the absorption of the skin-care active ingredient into the skin and applying the first agent that can dissolve the following two agents in use. Provided is a method of using a two-part skin improvement cosmetic composition by attaching a porous patch two formulated with anhydrous lyophilized patches to the skin by lyophilizing the composition.

Some of the active ingredients for skin care are present in a stable state in the liquid phase, there are some components that can be preserved for a long time in the solution phase, but when formulated in the liquid phase unstable in the liquid phase, there is a component that is less effective activity over time during storage and distribution.

The present invention provides a cosmetic composition comprising a skin improvement component in an anhydrous patch by a lyophilization process in a method for stably formulating all active ingredients regardless of the stability of ingredients in a solution.

In the present invention, the patch 2 is an active ingredient for skin beauty by dissolving the patch at the skin surface with a liquid or gel 1 agent containing a component that promotes absorption of the skin improvement component into the skin and which can dissolve the patch when used. Can be more effectively absorbed into the skin.

That is, in the two-part skin improvement patch of the present invention, after applying an appropriate amount of a liquid or gel-like agent to the skin, a porous patch 2 agent in the form of a sheet made of a water-dispersible polymer containing the active ingredient for skin beauty is stably applied to the skin. When attached, it slowly melts and adheres to the skin, forming a uniform patch protection film on the skin. Therefore, even when the application is evenly attached to the desired thickness and width even in a severe bend on the face due to acne and wounds.

The patch protective film is formed by converting the structure of the patch 2 agent into a sustained release patch form while dissolving in a liquid or gel 1 agent applied to the skin, and this patch protective film continuously absorbs the active ingredient for a long time and exerts excellent moisturizing power. . That is, a small amount of moisture or oil secreted from the skin is suppressed by the protective film formed on the surface in contact with the air, thereby promoting dissolution of the two skin-derived active ingredients and further spreading the skin-derived active ingredient into the skin. It becomes active so that the continuous absorption of the active ingredient occurs in the skin direction at high concentration in the patch, which is a water dispersible polymer layer.

Hereinafter, the configuration of the present invention will be described in detail.

The present invention provides a patch-type formulated by lyophilizing a liquid or gel-like agent comprising a solvent and a component for promoting the absorption of the skin-active active ingredient into the skin, and a composition containing a water-dispersible polymer and the skin-effective active ingredient. Provided is a two-part skin improvement cosmetic composition comprising a two agent.

In addition, the present invention is formulated by lyophilizing a composition comprising a liquid or gelling agent comprising a solvent and a component for promoting the absorption of the skin-active active ingredient into the skin, and a composition containing a water-dispersible polymer and the skin-effective active ingredient. Provided is a skin improvement cosmetic kit comprising a patch-type two agent.

Furthermore, the present invention comprises the steps of applying to the skin a liquid or gel-like agent comprising a component for promoting the absorption of the solvent and the skin-effective active ingredient into the skin; And lyophilizing a composition comprising a water dispersible polymer and an active ingredient for skin care, and attaching the patch-type two agent formulated to the skin.

In the two-part skin improvement cosmetic composition of the present invention, one agent in liquid or gel form contains a solvent suitable as a periodic component and an ingredient that promotes absorption of the skin-care active ingredient into the skin as an active ingredient.

In addition, the liquid or gelling agent of the present invention may further include an additive which may be used in the cosmetic composition in addition to the above components.

The solvent which is a periodic component of the liquid or gelling agent of the present invention may be used alone or as a mixture of two or more thereof.

In the present invention, the solvent may be used without limitation as long as it is a solvent that can be used in the liquid or gel cosmetic composition.

Solvents used in the present invention include alcohol, water, polyalcohols and the like.

In the present invention, the "component which promotes the absorption of the skin improvement component into the skin" is a component that can penetrate the skin improvement component into the skin more quickly and efficiently and efficiently. Phospholipid, Phosphhatidyl, Glycosylceramides, Fatty acid, Nonionic Surfactants, Sucrose Fatty acid ester , Gelucire, Glyceride, Phospholipids, etc. or Aminosugar, Amino acid, Glucagon, Glysirizine, Glutamic acid, PEG, Acrylcarnitines, Citric acid (Citric acids), menthol, ethyl alcohol, propylene glycol, butylene glycol, ethylene glycol, glycerin, triacetin and the like, one or two or more.

In the two-component porous skin improvement patch cosmetic composition of the present invention, the patch-type two agent includes a water dispersible polymer and a skin improvement effect ingredient as the main ingredient.

In addition, the patch-type two agents of the present invention may further include an additive that can be used in the cosmetic composition in addition to the above components.

The water-dispersible polymer which is a periodic component of the patch type 2 agent of this invention can use single or a mixture of 2 or more.

In the present invention, the water-dispersible polymer may have a characteristic of being able to easily form a skin protective film by dissolving and dissolving slowly on the skin when the skin is adhered after applying the first agent in liquid or gel form.

For the above characteristics, the present invention includes a collagen or modified collagen which is one of the natural water dispersible polymers, and a freeze-drying process of an aqueous solution containing any one or more water dispersible polymers selected from natural and synthetic polymers as a dissolution promoting component of the patch. It is preferable that the dissolution time at the time of adhesion to the skin is prepared by the patch of the porous structure through 5 to 30 minutes.

In the present invention, when used in combination with any one or more water-dispersible polymers selected from natural polymers and synthetic polymers rather than using collagen or modified collagen alone, less squeeze after skin adhesion, and faster dissolution rate is more preferred.

As one or more water-dispersible polymers selected from natural polymers and synthetic polymers other than collagen or modified collagen that can be used in the present invention, natural polymers have higher dissolution rate and faster patch protective film formation rate when applying skin than synthetic polymers. Do.

Natural polymers that can be used in the present invention include hyaluronic acid, gelatin, agar, carrageenan, algin, chitosan, starch, galactomannan, glucomannan, guar gum, locust bean gum, alginate, xanthan gum and gellan, and most preferably Hyaluronic acid can be used.

Synthetic polymers that can be used in the present invention include cellulose acetate phthalate, polyvinyl acetate phthalate, methacrylic acid gelatin, hydroxymethylcellulose phthalate, hydroxypropylmethylcellulose phthalate, hydroxyalkylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate Succinate polyvinylpyrrolidone, polyvinyl alcohol, polyethylene oxide, polyvinyl acrylic acid, hydroxyethyl cellulose, hydroxy propyl cellulose, hydroxypropyl methyl cellulose and the like.

Skin improvement effect ingredients that can be contained in the patch 2 agent in the present invention is a whitening ingredient arbutin, mulberry extract, licorice extract, sesame seed extract, white extract, ethyl ascorbyl ether, ascorbyl glucoside, magnesium ascorbyl phosphate, as Corbinic acid, kojic acid, glutathione, tyrosinase, diosmetin, maysignan, vitamins, etc.As an anti-wrinkle ingredient, Asiaticoside, ubidecarenone, peony extract, polyethoxylateddretinamide, hydroxyproline, retinol Acid, alphahydro acid (AHA), adenosine, botox and the like, and other known anti-inflammatory ingredients, anti-atopic ingredients, antimicrobial ingredients, etc., as long as it is known as an active ingredient for skin beauty is not limited.

Additives that may be contained in the liquid or gel form of the present invention are emulsifiers, anti-sticking ingredients, preservatives, humectants, thickeners, pH adjusters and the like. At this time, the moisturizing agent may be polyoxyethylene hardened castor oil, the thickener may be a carbomer, the pH adjusting agent may be triethanolamine.

Additives that may be included in the patch type 2 of the present invention are a plasticizer, an emulsifier, a stickiness reducing component, a fast disintegrating auxiliary component, a preservative, a scrub agent, and the like.

In the present invention, as an emulsifier Sodium lauryl sulfate (SLS); Dioctyl sodium sulfosuccinate (DSS); Benzalkonium chloride; Benzetonium chloride; Cetamide, such as trimethyltetradecyl ammonium bromide; Fatty acid sugar esters; Glyceryl monooleate; Polyoxyethylene sorbitan fatty acid esters; Dimethylpolysiloxanes; Sorbitan esters; Or lecithin and the like, which may be used alone or in a mixture of two or more.

In the present invention, the stickiness reducing component is a silicone compound having low viscosity from high viscosity organopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopenta, such as dimethylpolysiloxane, methylfetylpolysiloxane, methylhydrogenpolysiloxane, dimethylsiloxane and methylphenylsiloxane copolymer. Cyclic siloxanes such as siloxane, dodecamethylcyclohexasiloxane, tetramethyltetrahydrocyclocyclotetrasiloxane, tetramethyltetrapetylcyclotetrasiloxane, dimethylpolysiloxane of high degree of polymerization, silicone rubber such as dimethylsiloxane, methylphenylsiloxane copolymer and silicone rubber Cyclic siloxane solution, trimethylsiloxysilicate, cyclic siloxane solution of trimethylsiloxysilicate, higher alkoxy modified silicones such as stearoxy silicone, higher fatty acid modified silicone, alkyl modified silicone, amino modified silicone, fluorine modified silicone, polyquater Acids, alone or a mixture of two or more selected from the group consisting of silicon resin and silicon resin are preferred.

Preservatives in the present invention may be used alone or in the form of a mixture of two or more, and specific examples of the preservatives include methyl parabens, ethyl parabens, ethyl parabens, propyl parabens, butyl parabens, quaternium-15, imidazolidinyl urea, Phenoxyethanol, benzalkonium chloride, chlorohexidine gluconate and triclosan.

As a plasticizer in the present invention, sorbitol; Xylitol; Erythritol; Mannitol; glycerin; Polyhydric alcohols such as polyethylene glycol, polypropylene glycol and butylene glycol; PEG; Trehalose; Betaine and the like, which may be used alone or in a mixture of two or more.

In the present invention, the fast disintegrating auxiliary component may be used in the form of a mixture of two or more selected from organic powder and inorganic powder to prevent agglomeration during film dissolution or powder having a porous structure.

Examples of the organic powder in the present invention are polyamide powder, polyester powder, polyethylene powder, polypropylene powder, polystyrene powder, polyurethane powder, benzoguanamine powder, polymethylbenzoguanamine powder, tetrafluoroethylene powder, polymethylmetha Acrylate powder, cellulose, silk powder, nylon powder, polyamide 12, polycaprolactam, silicone elastomer spherical powder having crosslinked structure of dimethyl silicone, spherical polymethylsilsesquioxane powder, polymethylsilsesquioxane Surface-covered silicone elastomer spherical powder, styrene-acrylic acid copolymer, divinylbenzene-styrene copolymer, vinyl resin, urea resin, phenolic resin, fluorine resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, fine Crystalline fiber powder, starch powder, laurolysine and the like.

Examples of the inorganic powder in the present invention include titanium oxide, zirconium oxide, zinc oxide, cerium oxide, magnesium oxide, barium sulfate, calcium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, talc, mica, kaolin, sericite, white mica, synthetic mica. , Gold mica, red mica, biotite, lithia mica, quartz, anhydrous silicic acid, aluminum silicate, magnesium silicate, aluminum aluminum silicate, calcium silicate, barium silicate, strontium silicate, tungstate metal salt, hydroxyapatite, bamiculite, hydrite , Bentonite, montmorillonite, hectorite, zeolite, ceramic powder, dicalcium phosphate, alumina, aluminum hydroxide, boron nitride, bromine nitride, silica and the like.

Ingredients that can be used as a scrub agent in the present invention may be particles of mechanically finely ground natural ingredients such as dried apricot seed, peach seed, walnut shell, or polymer microparticles such as synthetic polyethylene, urethane, nylon, etc. Can be.

In the present invention, the freeze-drying process is a step of preparing the lyophilized cosmetic composition through heating, stirring and dispersing the mixture, and lyophilization after filtration and sterilization, the stirring is performed at a temperature range of 5 to 50 ℃, preferably It is carried out at 15 to 30 ℃. The freeze-dried mixture was frozen at low temperature, and then freeze-dried at -40 to -80 ° C to prepare a freeze-dried composition of white to pale yellow color.

The lyophilized composition obtained as described above can be stored for a long time by securing excellent stability to the temperature and humidity of the raw material itself, easy to apply as a patch, and can withstand without being affected by the effects of temperature and humidity that may occur during the production process. It has an effect.

In addition, since there are no surfactants or organic solvents that may cause ethanol components or sensitizing side effects, they are not harmful to human use.

The two-part porous skin improvement cosmetic composition prepared by the freeze-drying method of the present invention contains a component that promotes the absorption of the skin-effective active ingredient into the skin and, when used, can be dissolved in the following two agents, and the skin-active active ingredient By lyophilizing the moisture gel cosmetic composition comprising a heating process without a heating process to prepare a two-component skin improvement cosmetic composition prepared in the form of a porous patch to further improve the stability of the skin-effective active ingredients and excellent application to the skin After applying the two-component porous skin improvement cosmetic composition prepared by the freeze-drying method that is dissolved by the moisture of the skin and can be easily applied to deep wrinkles, curved surfaces as well as to the hair part of the skin and does not detach from the skin even after prolonged adhesion. It has a very good effect that can be provided.

Hereinafter, the configuration and effects of the present invention through the embodiments will be described in more detail. These examples are only for illustrating the present invention, but the scope of the present invention is not limited by these examples.

Comparative Example 1-5 and Example 1-6 Preparation of Two-Lyophilized Porous Patch Type

Hydroxypropylmethyl cellulose and hydroxyethyl cellulose were prepared as synthetic polymers, and collagen, heat-modified collagen, and hyaluronic acid were prepared as natural polymers.

Each of the polymers and combinations thereof was prepared as a patch through a freeze-drying process by dissolving ascorbyl glucoside as 2.0% of the weight of the final patch as a skin improvement component using an aqueous solution of the weight ratio shown in Tables 1 to 2 below.

The patch was prepared by dispersing the mixtures of Comparative Examples 1 to 5 and Examples 1 to 6 at 25 ° C. with heating, stirring, and then sterilizing by filtration and using a doctor blade on a silicone release-treated polyester (peeled layer). After coating, the porous patch was prepared by freeze drying at reduced pressure at -40 ° C, and cut into 2 cm x 2 cm to prepare each sample.

A scanning electron microscope (SEM) photograph showing the porous structure of the lyophilized patch prepared in Example 1 is shown in FIG. 1.

Comparative Example-Composition of Porous Patch after Freeze-Drying (Unit: wt%) Raw material name Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Collagen 98 - - - - Thermodegenerated collagen - 98 - - - Hyaluronic acid - - 98 - - Hydroxyethyl
cellulose - - - 98 - Hydroxypropyl
Methylcellulose - - - - 98 Ascorbylglucoside 2.0 2.0 2.0 2.0 2.0

Example- Composition of Porous Patches after Freeze-Drying (Unit: wt%) Raw material name Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Collagen 49 - 49 - 49 - Thermodegenerated collagen - 49 - 49 - 49 Hyaluronic acid 49 49 - - - - Hydroxyethyl
cellulose - - 49 49 - - Hydroxypropyl
Methylcellulose - - - - 49 49 Ascorbylglucoside 2.0 2.0 2.0 2.0 2.0 2.0

Comparative Example 6-11: Preparation of a Patch 2 Bin by Heating and Drying

Hydroxypropylmethyl cellulose and hydroxyethyl cellulose were prepared as synthetic polymers, and collagen, heat-modified collagen, and hyaluronic acid were prepared as natural polymers.

As a water-dispersible polymer, each of the polymers and combinations thereof was prepared as a patch by dissolving ascorbyl glucoside as 2% of the weight of the final patch as a skin improvement component by the aqueous solution of the ratio shown in Table 3 below.

The patch was prepared by dispersing the mixed solution of Comparative Examples 6 to 11 at 25 ° C. while heating and stirring, and then filtering and sterilizing the coating to a silicon release-treated polyester (peel layer) using a doctor blade at least 100 μm, followed by 60 ° C. Heat-dried in the drying oven of the patch was prepared, cut into 2 cm × 2 cm to prepare each sample.

Comparative Example-Composition of Porous Patch after Heat Drying (Unit: wt%) Raw material name Comparative Example 6 Comparative Example 7 Comparative Example 8 Comparative Example 9 Comparative Example 10 Comparative Example 11 Collagen 49 - 49 - 49 - Thermodegenerated collagen - 49 - 49 - 49 Hyaluronic acid 49 49 - - - - Hydroxyethyl
cellulose - - 49 49 - - Hydroxypropyl
Methylcellulose - - - - 49 49 Ascorbylglucoside 2.0 2.0 2.0 2.0 2.0 2.0

Experimental Example 1: Investigation of the effect of maintaining the active stability of the skin improvement active ingredient in the patch by lyophilization

The active stability of the skin improvement active ingredient in the patch prepared in Examples 1 to 6 and Comparative Examples 6 to 11 was measured and the results are shown in Table 4 below.

Evaluation of the activity stability was set to 100 of the skin improvement active ingredient before the preparation with the patch, and the content of the skin improvement active ingredient after the preparation was expressed as a degree of relative content to the content before the preparation.

division Relative content (%) of skin improvement active ingredient after patch manufacture Example 1 100 Example 2 99 Example 3 100 Example 4 98 Example 5 99 Example 6 98 Comparative Example 6 32 Comparative Example 7 28 Comparative Example 8 31 Comparative Example 9 25 Comparative Example 10 27 Comparative Example 11 25

Table 4 shows that the patch prepared by the freeze-drying method compared to the heat-drying method maintains a higher content of the active ingredient in the patch after the patch is manufactured, resulting in higher activity stability. Therefore, it was determined that the formulation of the lyophilized method during patch preparation would be preferable for maintaining the active stability of the skin improvement active ingredient.

Experimental Example 2: Investigation of the dissolution rate and properties of the patch

The dissolution rates and properties of 5 ml of each solvent were evaluated with the patches prepared in Comparative Examples 1 to 5 and Examples 1 to 6, and the solution in which the patches were dissolved was applied to the skin to evaluate the sliding phenomenon. Tables 5-6 are shown. (X: not used)

Comparative Example Dissolution Rate and Properties of Lyophilized Porous Patches Raw material name Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Purified water 10 minutes
jungle 8 minutes
jungle 30 seconds
jungle 20 seconds
jungle 1 sec
jungle ethanol Gelation Gelation X X X Squalane X X X X X Triethylhexinoin X X X
Wet X
Wet X
Wet

EXAMPLES Dissolution Rate and Properties of Lyophilized Porous Patches Raw material name Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Purified water 20 seconds 15 seconds
2 minutes 1 minute 3 minutes 2 minutes ethanol X X X X X X Squalane X X X X X X Triethylhexinoin X
Wet X
Wet X X X
Wet X
Wet

As can be seen from Tables 5 to 6, hydroxypropylmethyl cellulose, hydroxyethyl cellulose and hyaluronic acid, the dissolution rate is fast in water, but when the skin is applied, the phenomena appeared. The natural polymers, collagen and thermodenatured collagen, were very insoluble in water and were unsuitable for patch dissolving on the skin surface alone. However, collagen or thermo-denatured collagen and water-dispersible polymer combinations also had a fast dissolution rate in water and did not exhibit a rolling phenomenon when applying the skin. As a patch, it was judged to be suitable for users to use on real skin.

Example 7 and Comparative Example 12: Preparation of a water gel type 1 agent

Using the ingredients and contents shown in Table 7 below, the ingredients of phase B were mixed using a stirrer, and then the phase A was added to phase B and mixed with a stirrer. Was prepared.

division Raw material name function Example 7 Comparative Example 12 A phase ethanol menstruum 10 10 Polyoxyethylene Cured Castor Oil Moisturizer 0.4 0.4 Methyl paraben antiseptic Suitable amount Suitable amount B phase Purified water menstruum to 100 to 100 glycerin Ingredients that promote the absorption of skin improvement ingredients into the skin 4.0 4.0 Propylene glycol Ingredients that promote the absorption of skin improvement ingredients into the skin 4.0 4.0 Carbomer Thickener 0.30 0.30 Triethanolamine pH adjusting agent 0.30 0.30 Polyquaternium-51 Stickiness Reduction Ingredient 2.0 2.0 Ascorbylglucoside Whitening ingredients - 2.0

Experimental Example 3: Skin Application Test of Patch and Moisture Gel

The skin application test was performed using the following method to verify the effect of inhibiting pigmentation by the skin-improving porous patch and water gel prepared as in Comparative Examples and Examples.

First of all, 20 healthy men and women were selected to attach aluminum foil with 6 rows of 6 holes with a diameter of 7 mm in the lower part of both arms, and 60 mJ / ㎠ light using ORIEL Solar Simulator 1,000W at a distance of 10 cm from the arm. Was investigated. The irradiation site was washed well with 70% ethanol aqueous solution before irradiation. Example 7 and Comparative Example 12 were irradiated twice a day from 3 days before light irradiation to 3 weeks after light irradiation, and then applied to the blackened skin areas, respectively, and then the patches of Examples 1 to 2 were applied to the respective areas. After adhering, dissolving on the skin for 20 minutes, repeatedly dissolving with finger, and completely absorbed by the skin.

After prescribing the composition according to each of the comparative examples and examples according to the above method, the degree of pigmentation was visually determined, and the degree of pigmentation inhibition of the other compositions was compared to each of the comparative examples and examples, and there was no difference. Evaluated in two stages, and examined the occurrence of side effects of the skin and the results are shown in Table 8.

In addition, Figure 2 shows the appearance of the patch 2 agent of Example 1 after applying the moisture gel type 1 agent of Example 7 to the skin, and after attaching the patch type 2 agent of Example 1 to Figure 20 Repeated dissolution with finger on skin for minutes.

1 gel of water gel type 2 products of the patch type Effective (persons) No difference (persons) Side effects (persons) Example 7 - 0 20 0 Example 7 Example 1 12 8 0 Example 7 Example 2 14 6 0 Comparative Example 12 - 11 9 0 Comparative Example 12 Example 1 17 3 0 Comparative Example 12 Example 2 18 2 0 [Note]-: Use only 1 gel of moisture gel type, not 2 patches of patch type

As shown in Table 8, there was no room for improvement in the degree of pigmentation in Example 7 alone, and porous patches Examples 1 to 2 containing skin improvement components were applied to 12 of 20 test subjects with water gel. More than one showed significant skin tone improvement and no adverse effects were observed in the skin.

Experimental Example 4: Investigation of the storage effect of the present invention formula 2 skin improvement porous patch

The shelf life of the comparative example 12 which is 1 agent and the Example 1 cosmetic composition which is 2 agent was investigated.

It was investigated whether discoloration and deterioration (smell, etc.) occur during storage of each base at room temperature (25 ℃) and the results are shown in Table 9 below.

discoloration deterioration Comparative Example 12
(1 formula) Example 1
(2 formula) Comparative Example 12
(1 formula) Example 1
(2 formula) Immediately after manufacture ○ ○ ○ ○ After 1 month × ○ × ○ Two months later × ○ × ○ 5 months later × ○ × ○ 10 months later × ○ × ○ [Note] 1. Discoloration degree: ○ No discoloration, × Discoloration
2. Degree of deterioration: ○ Not deteriorated, × deteriorated

During storage of each base at room temperature (25 ° C.), the content of vitamin C derivatives, namely, ascorbyl glucoside, which is a potent ingredient was investigated, and the results are shown in Table 10 below. This was set to 100 for each content immediately after manufacture, and the change in content with time was shown using HPLC.

Vitamin C derivative content change (%) Comparative Example 12
(1 formula) Example 1
(2 formula) Immediately after manufacture 100 100 After 1 month 78.1 99.5 Two months later 53.2 99.3 5 months later 39.1 97.9 10 months later 26.7 95.7

It can be seen from Table 10 that the content of the vitamin C derivative in the lyophilized porous patch type 2 agent is maintained without a great decrease even after the storage time as compared to the gel formulation.

1 is a scanning electron microscope (SEM) image showing the porous structure of the lyophilized patch prepared in Example 1.

FIG. 2 is a photograph showing the appearance of the patch 2 agent of Example 1 attached to the skin after applying the moisture gel type 1 agent of Example 7. FIG.

Figure 3 is a photograph showing the appearance of repeatedly dissolving with a finger on the skin for 20 minutes after applying the moisture gel type 1 agent of Example 7 to the skin after applying the patch type 2 agent of Example 1.

Claims (18)

1 agent in a liquid or gel form containing a solvent and a component for promoting the absorption of the skin-active active ingredient into the skin, A patch-type two agent formulated by lyophilizing a composition containing a water-dispersible polymer and an active ingredient for skin care, Ingredients that promote the absorption of the skin-friendly active ingredient into the skin are phospholipids, phosphatidyl, glycosyl ceramides, fatty acids, nonionic surfactants, sugar fatty acid esters, gelrouser, glycerides, phospholipids, amino sugars, amino acids, glucagon At least one selected from the group consisting of glycyrrhizin, glutamic acid, PEG, acrylcarnitine, citric acid, menthol, ethyl alcohol, propylene glycol, butylene glycol, ethylene glycol, glycerin, and triacetin, The water-dispersible polymer is iii) collagen or modified collagen; And ii) a combination of hydroxypropylmethyl cellulose, hydroxyethyl cellulose or hyaluronic acid, 2-form skin improvement cosmetic composition. delete delete delete delete delete delete The method of claim 1, wherein the active ingredient for skin care is arbutin, mulberry extract, licorice extract, sesame seed extract, white extract, echyl ascorbyl ether, ascorbyl glucoside, magnesium ascorbyl phosphate, ascorbic acid, kojic acid, glutathione, Group consisting of tyrosinase, diosmethin, mayignignan, vitamin, asiaticoside, ubidecarenone, peony extract, polyethoxylatedretinamide, hydroxyproline, retinoic acid, alphahydroic acid (AHA), adenosine, and botox Two-part skin improvement cosmetic composition, characterized in that any one or more selected from. According to claim 1, wherein the one agent further comprises any one or more additives selected from the group consisting of emulsifiers, stickiness reducing component and preservatives, The tackiness reducing component is dimethylpolysiloxane, methylfetylpolysiloxane, methylhydrogenpolysiloxane, dimethylsiloxane-methylphenylsiloxane copolymer, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, tetramethyltetrahydrocyclocyclo Tetrasiloxane, tetramethyltetrapetylcyclotetrasiloxane, dimethylpolysiloxane of high degree of polymerization, cyclic siloxane solution of dimethylsiloxane and methylphenyl siloxane copolymer, trimethylsiloxy silicic acid, cyclic siloxane solution of trimethylsiloxy silicic acid, stearoxysilicone, higher fatty acid modification A two-part skin improvement cosmetic composition comprising one or more selected from the group consisting of silicone, alkyl modified silicone, amino modified silicone, fluorine modified silicone, polyquaternium, silicone resin and silicone resin. The method of claim 1, wherein the two agents further comprise at least one additive selected from the group consisting of a plasticizer, an emulsifier, a stickiness reducing component, a fast disintegrating aid, a preservative and a scrub agent, The tackiness reducing component is dimethylpolysiloxane, methylfetylpolysiloxane, methylhydrogenpolysiloxane, dimethylsiloxane-methylphenylsiloxane copolymer, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, tetramethyltetrahydrocyclocyclo Tetrasiloxane, tetramethyltetrapetylcyclotetrasiloxane, dimethylpolysiloxane of high degree of polymerization, cyclic siloxane solution of dimethylsiloxane and methylphenyl siloxane copolymer, trimethylsiloxy silicic acid, cyclic siloxane solution of trimethylsiloxy silicic acid, stearoxysilicone, higher fatty acid modification A two-part skin improvement cosmetic composition comprising one or more selected from the group consisting of silicone, alkyl modified silicone, amino modified silicone, fluorine modified silicone, polyquaternium, silicone resin and silicone resin. The method of claim 9 or 10, wherein the emulsifier is sodium lauryl sulfate (SLS), dioctyl sodium sulfosuccinate (DSS), benzalkonium chloride, benzogenium chloride, trimethyltetradecyl ammonium bromide, fatty acid sugar ester, glycerol A two-part skin improvement cosmetic composition comprising one or more selected from the group consisting of ryl monooleate, polyoxyethylene sorbitan fatty acid ester, dimethylpolysiloxane, sorbitan ester and lecithin. delete The method of claim 9 or 10, wherein the preservative is selected from the group consisting of paraoxybenzoic acid ester, quaternium-15, imidazolidinyl urea, phenoxyethanol, benzalkonium chloride, chlorohexidine gluconate and triclosan. Two-part skin improvement cosmetic composition, characterized in that it comprises any one or more. The method of claim 10, wherein the plasticizer comprises at least one selected from the group consisting of sorbitol, xylitol, erythritol, mannitol, glycerin, polyethylene glycol, polypropylene glycol, butylene glycol, PEG, trehalose and betaine Two-component skin improvement cosmetic composition. The method of claim 10, wherein the fast disintegrating auxiliary component is polyamide powder, polyester powder, polyethylene powder, polypropylene powder, polystyrene powder, polyurethane powder, benzoguanamine powder, polymethylbenzoguanamine powder, tetrafluoroethylene Powder, polymethyl methacrylate powder, cellulose, silk powder, nylon powder, polyamide 12, polycaprolactam, silicone elastomer spherical powder having a structure crosslinked with dimethyl silicone, spherical polymethylsilsesquioxane powder, polymethyl Silicon elastomer spherical powder coated with silsesquioxane, styrene / acrylic acid copolymer, divinylbenzene / styrene copolymer, vinyl resin, urea resin, phenol resin, fluorine resin, acrylic resin, melamine resin, epoxy resin, Polycarbonate resin, microcrystalline fiber powder, starch powder, laurolyzine, titanium oxide, Zirconium oxide, zinc oxide, cerium oxide, magnesium oxide, barium sulfate, calcium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, talc, mica, kaolin, sericite, mica, synthetic mica, gold mica, red mica, biotite, lithia Mica, silica, anhydrous silicic acid, aluminum silicate, magnesium silicate, magnesium aluminum silicate, calcium silicate, barium silicate, strontium silicate, metal tungstate salts, hydroxyapatite, bamicurite, hydrite, bentonite, montmorillonite, hectorite, zeolite, A two-part skin improvement cosmetic composition comprising at least one selected from the group consisting of ceramic powder, dicalcium phosphate, alumina, aluminum hydroxide, boron nitride, bromine nitride and silica. The two-part skin improvement according to claim 10, wherein the scrub agent comprises any one or more selected from the group consisting of dried apricot seeds, peach seeds, walnut shells, polyethylene microparticles, urethane microparticles, and nylon microparticles. Cosmetic composition. A patch or two agents formulated by lyophilizing a liquid or gel-like agent comprising a solvent and a component which promotes absorption of the skin-active active ingredient into the skin, and a composition containing a water-dispersible polymer and an active ingredient for skin-care are used. Including, Ingredients that promote the absorption of the skin-friendly active ingredient into the skin are phospholipids, phosphatidyl, glycosyl ceramides, fatty acids, nonionic surfactants, sugar fatty acid esters, gelrouser, glycerides, phospholipids, amino sugars, amino acids, glucagon At least one selected from the group consisting of glycyrrhizin, glutamic acid, PEG, acrylcarnitine, citric acid, menthol, ethyl alcohol, propylene glycol, butylene glycol, ethylene glycol, glycerin, and triacetin, The water-dispersible polymer is iii) collagen or modified collagen; And ii) a combination of hydroxypropylmethyl cellulose, hydroxyethyl cellulose or hyaluronic acid, Skin improvement cosmetic kit. delete

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