KR101071231B1 - Tablet for Producing Chlorine Dioxide and Preparation Method Thereof - Google Patents

Abstract

The present invention shows a tablet for producing chlorine dioxide when placed in water and a process for producing the same. Tablets according to the present invention are prepared by coating chlorite particles and then uniformly mixing the other substances with the coated chlorite particles in a certain ratio and then compressing them into various shapes. The tablets can quickly release chlorine dioxide when dissolved in water and form a clear chlorine dioxide solution. In addition, the tablet has an effect of improving the stability, dissolution rate and sterilization ability than the prior art.

Chlorine dioxide, chlorite, tablets

Description

Tablet for Producing Chlorine Dioxide and Preparation Method Thereof}

The present invention relates to a tablet that can rapidly release chlorine dioxide when dissolved in water, and more particularly, a dissolution rate is increased, including a blowing agent, and chlorite is coated with a pressure-sensitive adhesive to increase storage and stability and to improve interfacial properties. The present invention relates to a tablet and a method for preparing the same, which increase the sterilizing ability by increasing the penetration of the produced chlorine dioxide including the active agent.

Chlorine dioxide, known as the fourth-generation fungicide, is a strong oxidant, well soluble in water, highly volatile, exploded by heat, and has a strong oxidative bleaching effect. In addition, when sterilized with a conventional chlorine-based compound, it reacts with organic substances to produce carcinogens such as trihalomethane, but chlorine dioxide does not produce such carcinogens at all. The bactericidal effect of chlorine dioxide is superior to the fungicides such as hypochlorite, chlorine gas, ethylene oxide and glutaraldehyde which are commonly used. However, chlorine dioxide is a gas at room temperature, and reacts with a reducing agent, which is unstable and easily decomposed by light. Therefore, chlorine dioxide should be prepared immediately when used and should be used as soon as possible. For this reason, chlorine dioxide has not been widespread.

The most common method for producing the above-mentioned chlorine dioxide is to use a chlorine dioxide generator, which is not suitable for use on a small scale and requires specialized skills in operation and maintenance.

To overcome this problem, a solid composition has been invented which produces chlorine dioxide gas in contact with water and forms an aqueous solution of chlorine dioxide.

U. S. Patent 5,399, 288 discloses a solid composition which releases chlorine dioxide immediately after dissolution in water. The composition comprises chlorite, chlorine oxide releasing agent and proton donor present in a ratio of 4: 1: 3. However, the above technique does not describe the preparation technique of the tablet, but discloses only a powdered mixture of reactants.

Korean Patent No. 757618 discloses a solid composition in which chlorine dioxide can be generated after being dissolved in water. However, the solid composition includes a skeleton forming agent to maintain a porous skeletal structure, but due to this, the solid composition does not dissolve quickly when added and dissolved in water, and there is a problem in long-term storage.

The present invention is to solve the problems of the prior art as described above, to increase the dissolution rate by including a blowing agent and to generate chlorine dioxide rapidly when dissolved in water by increasing the shelf life and stability through the coating of chlorite using a pressure-sensitive adhesive Its purpose is to provide tablets that are easy to store and store and that can be easily used as needed. Still another object of the present invention is to provide a method for preparing the tablet.

The present invention relates to a tablet capable of rapidly producing chlorine dioxide when added to water. Tablets according to the present invention are based on the total tablet weight 5 to 40% by weight chlorite, 5 to 50% by weight solid acid, 3 to 15% by weight free halogen source, 1 to 25% by weight activator, 5 to 25% by weight desiccant %, Pressure-sensitive adhesive 4-25%, release agent 1-10%, foaming agent 0.5-5% by weight and surfactant 0.5-2% by weight.

More specifically, the chlorite is an alkali metal salt, an alkaline earth metal salt or a mixture thereof and preferably sodium chlorite. Preferable particle size of the chlorite is 20 to 60 mesh, more preferably 30 to 40 mesh.

The solid acid may be an organic solid acid, an inorganic solid acid, or a mixture thereof. The organic solid acid may be citric acid (citric acid), tartaric acid, amidosulphonic acid, fumaric acid, malic acid, or a mixture thereof, and the inorganic solid acid may be sodium hydrogen sulfate, Potassium sulfate or a mixture thereof, preferably citric acid (citric acid) is preferred as the organic solid acid, sodium hydrogen sulfate is preferred as the inorganic solid acid. In this case, the preferred particle size of the solid acid is 20 to 60 mesh, more preferably 30 to 40 mesh.

The free halogen source is lithium hypochlorite, isocyanate dichloride, trichlorocyanuric acid or mixtures thereof, preferably isocyanate dichloride. The preferred particle size of the free halogen source is 50 to 150 mesh, more preferably 80 to 100 mesh.

The activator is ammonium sulfate, lithium persulfate, potassium persulfate, sodium persulfate or mixtures thereof and is preferably sodium persulfate. The preferred particle size of the activator is 30 to 80 mesh, more preferably 30 to 40 mesh. Such activators have the function of neutralizing the sterilizing solution to reduce corrosion of the sterilized target and to increase the production of chlorine dioxide.

The desiccant is an alkali metal salt, which is calcium chloride, magnesium sulfate, sodium sulfate, magnesium chloride, or a mixture thereof, and preferably magnesium sulfate. The particle size of the desiccant is 40 to 100 mesh, more preferably 80 mesh.

The pressure-sensitive adhesive is polyvinylpyrrolidone, sodium alginate, glutin, agar or a mixture thereof and preferably sodium alginate. These tackifiers can increase the physical binding strength between the components of the tablet to increase the firmness of the tablet and to prevent breakage of the tablet. On the other hand, chlorite can be combined with materials such as solid acids or free halogen sources. Used as coating material for chlorite particles to protect from direct contact. When the chlorite particles are coated using such an adhesive, the shelf life of the tablet may be increased by about three times compared to that of the chlorite particles.

The release agent is adipic acid, boric acid, sodium chloride, magnesium stearate, talc powder, fine silicon dioxide or a mixture thereof and is preferably adipic acid. The particle size of the release agent is preferably 100 to 200 mesh, more preferably 200 mesh. These release agents have the function of increasing the particle flow of the materials and reducing the friction between the tablet and the mold.

The blowing agent is carbonate, sodium carbonate, sodium bicarbonate, potassium carbonate, potassium hydrogen carbonate, calcium carbonate, magnesium carbonate or mixtures thereof, preferably sodium hydrogen carbonate. The particle size of the blowing agent is 20 to 100 mesh, more preferably 30 to 60 mesh. These blowing agents oxidize to produce carbon dioxide, resulting in a partial foaming effect, stirring the dissolved reactants and increasing their reactivity.

The surfactant is an anionic surfactant characterized by an alkylbenzenesulfonate salt, preferably lauryl sodium alkylbenzenesulfonate salt. Preferable particle size of the surfactant is 100 to 200 mesh, more preferably 200 mesh. Such surfactants can enhance the sterilization and cleaning ability of tablets by reducing the surface tension of the chlorine dioxide solution and increasing the permeability of the chlorine dioxide solution.

The tablets according to the invention are characterized in that they are effervescent tablets.

In addition, the manufacturing method of the tablet according to the present invention in the stirring tank filled with water of 20 to 50 times the weight of the pressure-sensitive adhesive, preferably in the stirring tank filled with water of 30 to 40 times the weight of the pressure-sensitive adhesive 4 Adding to 12 wt% and heating to a temperature of 60 ° C. to 80 ° C., followed by stirring to form a tacky solution; 5-40% by weight of chlorite particles are added to the coating apparatus and the drying temperature is Spraying the adhesive to coat the chlorite particles with a pressure-sensitive adhesive at a temperature of 60 ° C. to 100 ° C. or lower, and stopping the coating and drying if the moisture content falls below 1% and storing the product in a container; Putting the other ingredients constituting the tablet into a dryer and then putting them in a container when the moisture content is 1% or less; Continuously adding 9 to 52% by weight of coated chlorite, 0.5 to 5% by weight of blowing agent, 0.5 to 2% by weight of surfactant, and 5 to 25% by weight of desiccant to the mixing apparatus and stirring for 10 to 20 minutes; Adding 5-50% by weight solid acid, 1-25% by weight activator, 3-15% by weight free halogen source and stirring for 10-20 minutes to the mixture; 1 to 10% by weight of a release agent is added to the obtained mixture, followed by mixing for 10 to 15 minutes and compressing the resulting composition in a purification apparatus.

Preferably provides a process for the production of tablets, it characterized in that the pressure is controlled to be purified from 25KN / m ² depending on the size of tablets to 100KN / m ^2.

Tablets prepared by the above method is stored in a container that can block moisture and light, the container may be a plastic aluminum bag or plastic drum.

Tablets according to the invention are made by compressing the combined materials in a machine. Tablets may be made in a variety of masses and forms to suit different situations by various means known in the art, such as tableting, extrusion, and the like. Mass of tablet from 0.3 grams to 80 grams It can be round, stick, oval and have various shapes.

Tablets according to the present invention can form chlorine dioxide solutions after being added to water or can produce chlorine dioxide by fumigation or stripping the solution. Tablets do not generate chlorine dioxide under dry conditions except when added to water or absorbing moisture.

The tablet according to the invention dissolves in water within 10 minutes and rapidly forms a clear, neutral chlorine dioxide solution to release chlorine dioxide. In addition, it has the effect of increasing the stability of the product through the coating operation using the adhesive.

Hereinafter, the examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited by these examples in accordance with the gist of the present invention, those skilled in the art to which the present invention pertains. Will be self-evident.

Example 1: Preparation of tablets based on 10 g

Ingredient weight% Sodium chlorite (content ≥ 80%), kg 34 Isocyanide dichloride, kg 13 Sodium hydrogen sulfate, kg 21 Sodium persulfate, kg 20 Magnesium sulfate, kg 5 Sodium alginate, kg 2.5 Lauryl Sodium Alkylbenzene Sulfonate, kg 0.5 Sodium carbonate, kg One Adipic acid, kg 3

First, dissolve 2.5 kg of sodium alginate in 80 kg of 60 kg of water to make an aqueous sodium alginate solution. 34 kg of sodium chlorite particles having a particle size of 40 mesh were made using a sieve vibrator, and then put into a coating body sprayed with an adhesive solution. The weight of the pressure-sensitive adhesive was 1 to 4 times compared to the chlorite and the drying temperature was less than 100 ℃. Coating and drying of the chlorite particles continued until the water content of the intermediate mixture was below 1%. The prepared intermediate mixture was stored in a dry place and placed in a plastic bag or container.

Using a grinder and a sieve vibrator, 40 mesh sodium hydrogen sulfate, 40 mesh sodium persulfate, 80 mesh sodium persulfate, 40 mesh magnesium sulfate, 60 mesh sodium carbonate particles (adipic acid and lauryl sodium alkylbenzene sulfonate Is used without using the grinder and sieve vibrator). To control the moisture content of all components below 1%, they were dried in an oven, stored in a dry place and placed in plastic bags or containers.

36.5 kg of coated sodium chlorite, 1 kg of sodium carbonate, 0.5 kg of lauryl sodium alkylbenzene sulfonate and 5 kg of magnesium sulfate were continuously added to the mixing apparatus and each was mixed. Then 21 kg of sodium hydrogen sulfate, 20 kg of sodium persulfate and 13 kg of isocyanate dichloride were added. Finally 3 kg of adipic acid was added to form a 100 kg mixed composition.

To make the mixed composition into 10g tablets Compression was carried out using a punch with a diameter of 25 mm in a purification apparatus under a pressure of 50 KN / m ² . The tablets thus produced were packaged using an aluminum plastic bag.

※ How to measure the concentration of chlorine dioxide and how to calculate the production rate.

1. How to measure the concentration of chlorine dioxide

(1) The tablet is dissolved in water having a weight 1000 times that of the tablet. The chosen container is a brown scalpel that can protect from light. Purification dissolves in 10 minutes and bubbles and yellow chlorine dioxide are generated with dissolution.

(2) 100 mL distilled water, Phosphate buffer solution (pH 7.2, Aldrich), chlorine dioxide solution to be measured at a concentration of 10-50 mL and 10 mL of potassium iodide solution (concentration 50 g / L, Aldrich) are added to a 500 mL iodine flask and each is mixed uniformly. The pH measured from the acidizer is maintained at 7 using a phosphate buffer solution. Using a sodium thiosulfate solution with 0.01 molarity, titrate until the color of the mixed solution turns pale yellow. When starch solution (concentration 1g / 100ml, Aldrich) is added, it turns blue and continues to titrate until the color of the mixed solution disappears. The volume of sodium thiosulfate solution consumed is represented by A.

(3) 2.5 mL of a hydrochloric acid solution having a 2.5 molar concentration is added to the solution titrated in (2) above, and the mixed solution is placed in a dark place for 5 minutes. Titrate with 0.01 mol of sodium thiosulfate solution until the color of the mixed solution disappears. The volume of sodium thiosulfate solution consumed is represented by B.

(4) 100 mL distilled water, phosphate buffer solution (pH 7.2, Aldrich) and 50 mL chlorine dioxide solution (or diluent thereof) are added into a 500 mL iodine flask, each of which is mixed uniformly, and then the pH is adjusted to 7 by adding phosphate buffer solution. . Then, high purity nitrogen is added for about 20 minutes to remove chlorine dioxide until the color of the solution becomes dark to light. Add 10 mL of potassium iodide solution, titrate with 0.01 mol of sodium thiosulfate until the color of the mixture turns pale yellow, and add 1 mL of starch solution (concentration 1g / 100ml, Aldrich) to blue. Continue titration until the color of the mixed solution disappears. The volume of sodium thiosulfate solution consumed is represented by C.

(5) 2.5 mL of a hydrochloric acid solution having a 2.5 molar concentration is added to the solution titrated in (4), and the mixed solution is placed in a dark place for 5 minutes. Titrate with 0.01 mol of sodium thiosulfate solution until the color of the mixed solution disappears. The volume of sodium thiosulfate solution consumed is represented by D.

(6) calculation method

The formula is

Where A, B, C and D represent the volume (mL) of sodium thiosulfate solution consumed, V represents the volume (mL) of chlorine dioxide solution and c represents the concentration (mol / L) of sodium thiosulfate solution.

(7) The detection limit of this method is 0.1 mg / L, the yield is 98.0%, and the relative standard deviation (RSD) is ≤10%.

2. Calculation method of chlorine dioxide production rate

The yield is calculated by multiplying the number of moles of chlorine dioxide produced by the number of moles of chlorite in the tablet and multiplying by 100. Generally, the actual sodium chlorite content of industrial sodium chlorite is about 80%, and the theoretical production rate of sodium chlorite producing chlorine dioxide is about 80% under acidic conditions.

In 20L of tap water, 10g of tablets were added and after 20 minutes, the concentration of chlorine dioxide was 63.6mg / L. The yield was 62.8% and the pH of the solution was 7.2.

The reduction rate of chlorine dioxide was 2.3% when the produced tablets were stored in a box where the temperature was maintained at 54 ° C. and the relative humidity was at least 75%.

Example 2: Preparation of tablets based on 1 g

Ingredient weight% Sodium chlorite (content ≥ 80%), kg 30 Isocyanide dichloride, kg 10 Citric Acid (citric acid), kg 40 Sodium persulfate, kg 2 Magnesium sulfate, kg 10 Sodium alginate, kg 2.5 Lauryl Sodium Alkylbenzene Sulfonate, kg 0.5 Sodium bicarbonate, kg 2 Adipic acid, kg 3

First, a coating apparatus for dissolving 2.5 kg of sodium alginate in 80 kg of 60 ° C water to make an aqueous sodium alginate solution, and then using a grinder and a sieve vibrator to make 30 kg of sodium chlorite particles having a particle size of 40 mesh, and then spraying an adhesive solution. Put in. The weight of the pressure-sensitive adhesive was 1 to 4 times compared to the chlorite and the drying temperature was less than 100 ℃. Coating and drying of the chlorite particles continued when the water content of the intermediate mixture was below 1%. The resulting intermediate mixture was stored in a dry place and placed in a plastic bag or container.

Using a grinder and a sieve vibrator, 40 mesh citric acid, 40 mesh sodium persulfate, 80 mesh sodium persulfate, 40 mesh magnesium sulfate, 60 mesh sodium bicarbonate particles (adipic acid and lauryl sodium alkylbenzene sulfonate Is used without using the grinder and sieve vibrator). To control the moisture content of all components below 1%, they were dried in an oven, stored in a dry place and placed in plastic bags or containers.

32.5 kg of coated sodium chlorite, 2 kg of sodium bicarbonate, 0.5 kg of lauryl sodium alkylbenzene sulfonate and 10 kg of magnesium sulfate were continuously added to the mixing apparatus and each was mixed. Then 40 kg citric acid, 2 kg sodium persulfate and 10 kg sodium isocyanate dichloride were added. Finally 3 kg of adipic acid was added to form a 100 kg mixed composition.

The mixed composition was compressed using a 12 mm diameter punch in a purification apparatus under a pressure of 25 KN / m ² to make 1 g of tablets. The tablets thus produced were packaged using an aluminum plastic bag.

After 15 minutes of 1g tablets in 2L of tap water, the concentration of chlorine dioxide was 59.97mg / L. The yield was 67% and the pH of the solution was 6.2.

The reduction rate of chlorine dioxide was 3.1% when the produced tablets were stored in a box where the temperature was maintained at 54 ° C. and the relative humidity was at least 75%.

Example 3: Preparation of 10 g Tablets

Ingredient weight% Sodium chlorite (content ≥ 80%), kg 12 Isocyanide dichloride, kg 6 Sodium hydrogen sulfate, kg 40 Sodium persulfate, kg 2 Magnesium sulfate, kg 15 Polyvinylpyrrolidone, kg 1.5 Lauryl Sodium Alkylbenzene Sulfonate, kg 0.5 Magnesium hydrogencarbonate, kg 3 Sodium chloride, kg 20

The mixed composition according to Table 3 above was prepared using the technical methods described in Examples 1 and 2 and was 25 mm in diameter in a purification apparatus under a pressure of 50 KN / m ² to make the mixed composition 10 g tablets. Compressed using a punch. After putting 10 g of tablets in 20 L of tap water, the concentration of chlorine dioxide was 25.4 mg / L after 15 minutes. The yield was 70.8% and the pH of the solution was 5.8.

The reduction rate of chlorine dioxide was 2.1% when the produced tablets were stored in a box where the temperature was maintained at 54 ° C. and the relative humidity was 75%.

Example 4 Effect of Addition of Sodium Persulfate as an Activator

Ingredient Equation I Equation Ⅱ Sodium chlorite (content ≥ 80%), kg 28 28 Isocyanide dichloride, kg 10 10 Sodium hydrogen sulfate, kg 30 15 Sodium persulfate, kg 0 15 Magnesium sulfate, kg 17.5 17.5 Sodium alginate, kg 2 2 Lauryl Sodium Alkylbenzene Sulfonate, kg 0.5 0.5 Sodium bicarbonate, kg 2 2 Sodium chloride, kg 10 10

The mixed compositions according to Equations I and II are prepared using the technical methods described in Examples 1 and 2 and are used in a purification apparatus under a pressure of 25 KN / m ² to make the mixed composition into 1 g of tablets. Compression was carried out using a 12 mm diameter punch.

Table 5 below shows 1 g of tablets in 1 L of tap water and measured the concentration of chlorine dioxide after 15 minutes, and stored the produced tablets in a box maintained at 54 ° C. and having a relative humidity of at least 75% for 14 days. It shows the reduction rate of chlorine dioxide after. For convenience, the tablet made by Equation (I) is referred to as Product A, and the tablet made by Equation (II) is referred to as Product B.

Indicators Product A Product B Chlorine dioxide concentration, mg / L 96.6 113.6 PH of solution 5.8 7.3 Production rate,% 57.8 68 % Reduction in chlorine dioxide 3.1 3.3

The addition of activator sodium persulfate increased the production rate of chlorine dioxide by 10.2% and the chlorine dioxide solution became neutral.

Example 5 Effect of Coating with Adhesive on Storage Stability

Ingredient weight% Sodium chlorite (content ≥ 80%), kg 35 Isocyanide dichloride, kg 12 Sodium hydrogen sulfate, kg 25 Sodium persulfate, kg 15 Magnesium sulfate, kg 5.6 Sodium alginate, kg 3 Lauryl Sodium Alkylbenzene Sulfonate, kg 0.4 Sodium bicarbonate, kg One Adipic acid, kg 3

Product A was made by coating the chlorite particles with sodium alginate and Product B was simply made by combining sodium alginate with another material without coating. The mixed composition was prepared using the technical methods described in Examples 1 and ² and compressed using a 12 mm diameter punch in a tableting device under a pressure of 25 KN / m ² to make the mixed composition into 1 g of tablets.

Table 7 below shows 1 g of tablets in 1 L of tap water, and after 15 minutes, measured the concentration of chlorine dioxide and storing the produced tablets in a box having a temperature of 54 ° C. and a relative humidity of 14 days for 14 days. Show the reduction rate of chlorine dioxide.

Indicators Product A Product B Chlorine dioxide concentration, mg / L 129.7 131.4 PH of solution 6.7 6.6 Production rate,% 62.1 62.9 % Reduction in chlorine dioxide 4.1 11.3

The storage stability of products coated with sodium alginate was increased.

Example 6: Effect of the presence or absence of lauryl sodium alkylbenzene sulfonate

Name of the substance Equation I Equation Ⅱ Sodium chlorite (content ≥ 80%), kg 24 24 Isocyanide dichloride, kg 10 10 Sodium hydrogen sulfate, kg 29 29 Sodium persulfate, kg 11 11 Magnesium sulfate, kg 11.5 11.5 Sodium alginate, kg 2 2 Lauryl Sodium Alkylbenzene Sulfonate, kg 0 0.5 Sodium bicarbonate, kg 2 2 Adipic acid, kg 10.5 10

The mixed composition was prepared using the technical method described in Examples 1 and ² and compressed using a 16 mm diameter punch in a purification apparatus under a pressure of 25 KN / m ² to make the mixed composition into 2 g tablets.

The tablets produced by Equations I and II were added to tap water, respectively. The component proportions of the mixed compositions are shown in Table 8. For convenience, the tablet made by Equation (I) is referred to as Product A and the tablet made by Equation (II) is represented as Product B.

Conclusion: The minimum effective concentration of Product A for sterilizing Escherichia coli was 50 mg / L.

The minimum effective concentration of Product B for sterilizing E. coli was 40 mg / L.

CONCLUSIONS: The minimum effective concentration of product A to kill Staphylococcus aureus was 50 mg / L.

The minimum effective concentration of Product B for sterilizing Staphylococcus aureus was 40 mg / L.

Conclusion: The minimum effective concentration of product A for sterilizing Bacillus subtilis Barniger was 300 mg / L. The minimum effective concentration of Product B for sterilizing Bacillus subtilis Barniger was 250 mg / L.

Ten sterilization experiments of fiber

The minimum effective concentration of Product A for sterilizing bacteria in the wild was 300 mg / L. The minimum effective concentration of Product B for killing bacteria present in the wild was 250 mg / L.

In conclusion, the above experiments showed that there was an increase in bactericidal effect when lauryl sodium alkylbenzene sulfonate was included. Therefore, the reaction mechanism of lauryl sodium alkylbenzene sulfonate suggested that the surface tension of chlorine dioxide can be reduced and the permeability of the chlorine dioxide solution can be enhanced to enhance sterilization and purification ability.

Claims (17)

5 to 40 weight percent chlorite, 5 to 50 weight percent solid acid, glass, coated with 4 to 25 weight percent polyvinylpyrrolidone, sodium alginate, glutin, agar or mixtures thereof based on the total weight of the tablet 3 to 15 weight percent halogen source, 1 to 25 weight percent activator, 5 to 25 weight percent desiccant, 1 to 10 weight percent release agent, 0.5 to 5 weight percent blowing agent and 0.5 to 2 weight percent surfactant refine. The method of claim 1, Chlorite is an alkali metal salt, alkaline earth metal salt or a mixture thereof. The method of claim 1, The solid acid is an organic solid acid, an inorganic solid acid or a mixture thereof. The method of claim 3, The organic solid acid is citric acid (citric acid), tartaric acid, amidosulphonic acid, fumaric acid, malic acid or a mixture thereof. The method of claim 3, Inorganic solid acid is sodium hydrogen sulfate, potassium sulfate or a mixture thereof. The method of claim 1, The free halogen source is a lithium hypochlorite, isocyanurium dichloride, trichlorocyanuric acid or mixtures thereof. The method of claim 1, Activator is ammonium sulfate, lithium persulfate, potassium persulfate, sodium persulfate or a mixture thereof. The method of claim 1, Desiccant is an alkali metal salt, The tablet characterized by the above-mentioned. The method of claim 8, Alkali metal salt is calcium chloride, magnesium sulfate, sodium sulfate, magnesium chloride or a mixture thereof. delete The method of claim 1, The release agent is adipic acid, boric acid, sodium chloride, magnesium stearate, talc powder, fine silicon dioxide or a mixture thereof. The method of claim 1, Blowing agents are tablets characterized by carbonates. The method of claim 12, The carbonate is sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate, magnesium carbonate or a mixture thereof. The method of claim 1, Surfactants are tablets characterized by anionic surfactants. 15. The method of claim 14, Anionic surfactant is a tablet characterized by the alkylbenzene sulfonate. (1) adding 4 to 12% by weight of the pressure-sensitive adhesive based on the total tablet weight to a stirring tank filled with water of 20 to 50 times the weight of the pressure-sensitive adhesive and heated to a temperature of 60 ℃ to 80 ℃ and stirred to form an adhesive liquid step; (2) 5 to 40% by weight of chlorite particles are added to the coating apparatus, and the water content drops to 1% or less after spraying the adhesive solution to coat the chlorite particles with a pressure-sensitive adhesive under conditions of a drying temperature of 60 ° C to 100 ° C. Stopping coating and drying and storing in containers; (3) putting the other components constituting the tablet into a dryer and then putting them in a container when the moisture content is 1% or less; (4) 9 to 52% by weight of coated chlorite, 0.5 to 5% by weight of blowing agent, 0.5 to 2% by weight of surfactant, 5 to 25% by weight of desiccant are continuously added to the mixing apparatus and stirred for 10 to 20 minutes. step; (5) adding 5-50% by weight solid acid, 1-25% by weight activator, 3-15% by weight free halogen source to the mixture and stirring for 10-20 minutes; (6) A method for producing a tablet comprising adding 1 to 10% by weight of a release agent to the obtained mixture, followed by mixing for 10 to 15 minutes, and compressing the resulting composition in a purification apparatus. The method of claim 16, wherein the pressure-sensitive adhesive is polyvinylpyrrolidone, sodium alginate, glutin, agar, or a mixture thereof.