KR100884831B1 - Slimming cosmetic composition comprising amino acid complex - Google Patents

Abstract

The present invention is a valine (Valine) having a function of reducing body fat and supplying energy quickly, glutamic acid (Glutamic Acid) to detoxify ammonia, promote collagen production, cysteine (fat burning), Provided is a slimming cosmetic composition containing an amino acid complex containing methionine for promoting fat metabolism. The slimming cosmetic composition according to the present invention provides an excellent lipolytic effect and a slimming cosmetic that promotes and supplements it by mixing an amino acid complex having functions such as promoting fat metabolism and reducing body fat.

Lipolysis, reduced body fat, amino acid complex              

Description

Slimming cosmetic composition containing amino acid complex

The present invention relates to slimming cosmetic compositions containing amino acid complexes, especially amino acid complexes in which valine, glutamic acid, cysteine and methionine are mixed.

As the modern society changes rapidly, the number of people gaining weight is increasing due to the westernization of modern people's living environment and eating habits. At the same time, concerns about the body shape of modern people are increasing due to cellulite, which makes the fat layer rugged. The cosmetics that are rapidly rising at this point are slimming agents.

However, the lipase used in the existing slimming composition has a problem that the cost is not good even though the efficacy is not good, and in the case of natural products known to be used as a slimming agent, the efficacy is not sure. Therefore, there is an urgent need for the development of natural materials that are excellent and effective as a slimming agent.

There are about 20 billion fat cells in the human body, which are responsible for accumulating or releasing energy in mammals. Within these cells, there are complex control principles for the accumulation and release of energy. If the supply is much greater than the demand for energy, it is stored as triglycerides in adipocytes and then broken down into free fatty acids and glucose when energy is depleted. Used. Obesity is caused by excessive energy accumulation due to the imbalance of this process, and is believed to be due to the increase or increase in the size of fat cells.

About 30 to 40% of modern people are known to be obese, and they may be accompanied by various adult diseases such as hypertension, hyperlipidemia, atherosclerosis, heart disease, diabetes, etc. However, this is because not only in terms of health but also the desire to improve the quality of life due to changes in the social environment such as improving the social status and economic independence of women, the interest in the beautiful body from the perspective of beauty is also increasing rapidly. to be. Accordingly, the demand for slimming and anti-cellulite cosmetics, which are effective in removing excessive subcutaneous fat and promoting skin elasticity, is steadily increasing.

Cellulite occurs only in women's skin and subcutaneous fat, causing rugged skin like rough orange peels due to circulatory disorders caused by the accumulation of excess fat and waste products. The cause of the cellulite is different from simple obesity, but since the cause is due to the increase or enlargement of fat cells, it is ultimately to make a slim and smooth body to break down and release fat in fat cells It can help.

Amino acids are an effective slimming cosmetic material that can eliminate cellulite. An amino acid is the smallest component of a protein, and hundreds to thousands of amino acids are linked to make up a protein. These aggregates of amino acids become proteins, which are essential sources of muscle, blood, skin, hair, enzymes, and so on. Among these amino acids, there are functions related to lipolysis, but there are no effective amino acid complexes that can be used alone in slimming cosmetics. Therefore, there is a need to find a way to make the best use of the lipolytic ability of amino acids.

Therefore, the technical problem to be achieved by the present invention is to provide an amino acid complex that can be applied to the slimming cosmetic even more effective amino acids essential to the human body to overcome this reality.

In order to achieve the above technical problem, the present invention has a function of reducing body fat and fast supply of energy (Valine), sugar and fat metabolism, glutamic acid (Glutamic acid) to detoxify ammonia, promote collagen production, fat burning Provided is a slimming cosmetic composition containing an amino acid complex of Cysteine acting and methionine promoting fat metabolism.

Slimming cosmetic composition according to the present invention as described above it is preferable that the valine, glutamic acid, cysteine and methionine are each contained 0.001 ~ 10g per 1kg slimming cosmetic composition. In other words, it was found that the most effective result of various experiments of the present inventors is that the amino acid complexes mixed with balim, glutamic acid, cysteine and methionine are included in an amount of 0.0004 to 4% by weight based on the total weight of the cosmetic composition.

The slimming cosmetic composition according to the present invention as described above will be described in detail through Examples and Experimental Examples. However, it is obvious that the contents of the present invention are not limited by the following experimental examples.

Example 1

0.25g of valin (Cat # V4638), glutamic acid (Cat # G8415), cysteine (Cat # C7352), and methionine (Cat # M5308) purchased from Sigma Co. Amino acid complexes were prepared.

Experimental Example 1: Comparison of lipolysis effect between amino acid complex and single amino acid

To determine whether amino acid complexes are more useful than slimming amino acids in slimming cosmetics, the following lipolytic effect tests were performed.

The amino acid complex used in this experiment was prepared in Example 1.

1 g of amino acid complexes and 1 g of t valine, 1 g of glutamic acid, 1 g of cysteine, and 1 g of methionine were compared with the following lipolysis tests in Comparative Examples 1-4.

The lipolytic effect test utilized the property that fat cells secrete glycerol during lipolysis. In this test, 3T3-L1 cells, pre-adipocytes, were treated with 2ug / ml of insulin, 2um of dexamethasone, and 110ug / ml of isobutylmethylxanthine in 24well plates. After 48 hours of incubation in a medium, the cells were incubated for about 9 days with 2ug / ml of insulin-treated medium to differentiate 3T3-L1 cells into adipocytes so that fat was accumulated in the cells and compared with amino acid complexes. Examples 1 to 4 were incubated for 24 hours.

At this time, the measured value of lipolysis was measured at 540 nm using a spectrophotometer (Beckman DU-7500), and lipase was used as a control.

Lipolytic effect rate was used in the following formula and the results are shown in Table 1.

Lipolytic Effectiveness (%) = absorbance of the experimental group (540 nm) / absorbance of the control group (540 nm) X 100

Experimental substance Lipolysis Effectiveness (%) Amino acid complexes 89.2 Comparative Example 1 45.2 Comparative Example 2 55.6 Comparative Example 3 62.1 Comparative Example 4 48.5

As a result of Table 1, it was found that the amino acid complexes presented in the present invention are more useful as a slimming cosmetic than when the amino acids are used alone.

Prescription Example

In order to evaluate the lipolysis effect by preparing the actual slimming cosmetics, the slimming cosmetics were prepared as shown in Table 2, wherein the amino acid complexes were 0.3: 1: 1, respectively, such that the gram ratio of valine, glutamic acid, cysteine, and methionine was 1: 1: 1: 1. g is mixed.

ingredient Content (% by weight) Amino Acid Complex Tocopheryl Acetate Sorbitasesquioleate Polysorbate 60 Beeswax Triethanolamine Carboxyvinyl Polymer Glycerin Squalane Propylene Glycol Liquid Paraffin Preservative Purified Water 1.2 0.1 2.0 2.0 2.0 0.5 0.5 4.0 3.0 6.0 10 system 100

Comparative prescription example

The comparative prescription example is for a comparative experiment with the prescription example, and refers to the composition excluding the amino acid complex in the prescription example.

Experimental Example 2: Evaluation of lipolysis effect of the slimming cosmetic of the present invention

In order to evaluate the usefulness of the cosmetic of the present invention as a slimming cosmetic, the lipolytic effect was evaluated. The effect was evaluated using the prescription example and the comparative example which contain 1.2% of amino acid complexes. The method used the same method as Experimental Example 1.

Lipolysis effect rate (%) Slimming cosmetics of prescription example 88.9 Slimming cosmetics of comparative prescription example 9.5

Experimental results show that the present invention containing an amino acid complex has a definite lipolytic effect as compared to the comparative formulation.

Experimental Example 3: Clinical trial on the slimming effect of the present invention slimming cosmetic

In order to investigate the slimming effect of the present invention, clinical trials were conducted on 10 healthy women aged 19 to 50 years with local obesity or cellulite on the thighs and hips (Method of testing primary irritant substances 38 (187). ): pp1500-1541). The sample used by the said prescription example and the comparative prescription example was used.

One side was prepared in Comparative Formulation Example, the other side was prepared in Formulation Example for one month, and the fat layer thickness was quantified with an image analyzer.

As a result of the experiment, the slimming cosmetic composition prescribed according to the present invention was found to have an excellent slimming effect with a 15% fat layer reduction.

As described above, the present invention, by developing an amino acid complex having a lipolytic effect such as body fat reduction, fat metabolism promotion, etc., proved the lipolysis effect that exceeds the single amino acid. The present invention is a useful invention in which a slimming cosmetic containing an amino acid complex is applied more effectively to amino acids essential to the human body than the existing slimming cosmetics, thereby increasing the practical and economic efficacy.

Claims (2)

Slimming cosmetic composition comprising an amino acid complex of a mixture of valine, glutamic acid, cysteine and methionine as an active ingredient. The slimming cosmetic composition according to claim 1, wherein the valine, glutamic acid, cysteine and methionine are each contained in an amount of 0.001 to 10 g per 1 kg of the cosmetic composition.