KR100792382B1 - A micro needle roller and forming mold thereof - Google Patents

Abstract

A micro-needle roller and a forming mold thereof are provided to simplify the structure thereof, and to reduce the processing time to be produced in a mass production at a low manufacturing cost. A micro-needle roller includes a cylindrical needle roller(11), plural micro-needles(25) and a roller handle. The micro-needles are formed to protrude from the outer circumference of the roller head. The roller handle is coupled to the roller head to make the roller head rotate. The roller head and the micro-needles are formed of a polymer resin material and are integrally formed. The polymer resin is a thermoplastic resin or a thermosetting resin. The roller handle has a roller head coupling portion having two clamp arms(44) having a rotary shaft protrusions(45).

Description

Micro needle roller and its molding die {A MICRO NEEDLE ROLLER AND FORMING MOLD THEREOF}

1 is a perspective view of a polymer microneedle roller according to an embodiment of the present invention.

2 is an exploded perspective view of a polymer microneedle roller according to an embodiment of the present invention.

3 and 4 are a perspective view and an exploded perspective view showing a microneedle roller forming mold according to the present invention.

5 to 7 is a perspective view showing a needle block, the coupling state of the lower plate base, lower plate base and the inner mold of Figure 4;

Explanation of symbols on the main parts of the drawings

10; Micro needle roller 11; Roller head

13; Rotary shaft coupling groove 15; Fitting projection

25; Micro needle 41; Roller handle

43; Roller head engaging portion 44; Clamp arm

45; Rotary shaft projection 47; Handle

100; Forming mold 110; Bottom plate base

130; Top base 150; Outside mold

170; Inner mold

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a micro needle roller, and more particularly, to a micro needle roller and a molding die thereof used for delivering cosmetics or drugs through the skin tissue and healing the skin tissue.

In general, the delivery of cosmetics or drugs through the skin is very low absorption rate because the drug is difficult to penetrate the stratum corneum. In particular, when the molecular weight is large, the water absorption becomes even lower. To improve this, a technique using a microneedle (also called a microneedle) has been proposed. The microneedles are used to form new channels that pass through some or all of the epidermal layer, and deliver the drug through or through the channels to the epidermal or underlying layer. According to this technology, even large molecular weight drugs such as insulin and hormones can be easily delivered through the skin. In addition, when microneedles penetrate and stimulate the dermis, burns and scars can be cured naturally. In addition, collagen production may be induced to maximize skin tone improvement and anti-aging effects.

Microneedle rollers are currently used as channel forming means by microneedles. The microneedle roller is a structure in which the microneedle protrudes from the surface of the roller head in a cylindrical roller head. As the roller head rotates, the microneedles form many channels in the skin at once. Examples of microneedle rollers are described in PCT WO / 0,247,555, PCT WO / 0,249,711 and the like.

However, such a conventional micro needle roller is composed of a micro needle stainless steel (stainless steel) material. And since the microneedle comes from the inside of the roller head, there is a limited space to place the pin inside the roller head. Therefore, there is a limit in reducing the spacing between microneedles. Usually the needle spacing is about 2 mm in a straight line distance. It is difficult to maximize the therapeutic effect by narrowing the gap between the needles. It is also cumbersome to require disinfection for repeated use. It is also made of stainless steel, which increases the price.

As another technique, as in Korean Utility Model Registration No. 115807, “Skin Scratches for Drug Administration”, a structure in which an intermediate material is interposed between circular skin needle plates and ten to hundreds of skin needle plates and intermediate materials are introduced. . However, this technique has a problem in mass production due to the complicated manufacturing process. For example, there are difficulties in the process due to the constraint that the skin needle plates must be displaced from each other. Therefore, it cannot be manufactured by going through a one shot process and has a disadvantage in that the process time is long.

It is therefore an object of the present invention to provide a microneedle roller and its molding die, which can be mass-produced at a low manufacturing cost by simplifying the structure and shortening the processing time.

Another object of the present invention is to provide a microneedle roller and its molding die, which can reduce the gap between the needles and improve the delivery effect of drugs or cosmetic products.

The present invention to achieve the above object is a cylindrical roller head; A plurality of microneedles protruding from the outer circumferential surface of the roller head; And a roller handle to which the roller head is rotatably coupled. Provides a microneedle roller in which the roller head and the microneedle are made of a polymer and are integrally formed with each other.

In the microneedle roller according to the present invention, the polymer resin is preferably a thermoplastic resin and a thermosetting resin. As the thermoplastic resin, for example, PC (Polycarbonate), Polyetherimide (PEI), Polymethylmethacrylate (PMMA), Polyacetal (POM), Polylatide (PLA), Polysulfone (PSU) and the like may be used. As the thermosetting resin, an epoxy resin, a phenol resin, a polyurethane resin, or the like may be used. In particular, the polymer resin is preferably a biodegradable polymer. For example, PLA (Polylatide), PLGA (Poly lactic-co-glycolic acid) is preferred.

In the microneedle roller according to the present invention, it is preferable that the roller handle has a roller head engaging portion comprising two clamp arms each having a rotating shaft projection, and the roller head has a rotating shaft engaging groove to which the rotating shaft projection is coupled. .

In addition, in order to achieve the above object, the present invention has a plurality of needle block formed with a plurality of micro-needle forming grooves on the inner side and the needle blocks are arranged in an annular shape to be in close contact when moving inward to form a cylindrical inner space Forming external mold; A lower plate base in the shape of a disc covering the lower portion of the outer mold while the needle blocks are in close contact; And a top plate base in the shape of a disc covering the top of the outer mold in a state in which the needle blocks are in close contact with each other.

The microneedle roller forming mold according to the present invention is fixed to any one of the lower plate base and the upper plate base, and when the needle blocks are in close contact with each other to form a cylinder, a plurality of hole forming blocks are inserted into the hole forming blocks having a fan shape. It is preferable that the branch further includes an internal mold.

And in the microneedle roller forming mold according to the present invention, it is preferable that the outer mold has 4 to 30 needle blocks. The depth of the microneedle forming groove may be 20 μm to 2 mm, and may be out of this range as necessary. In addition, the upper plate base and the lower plate base is preferably formed with an annular groove for rotation axis coupling.

Hereinafter, a microneedle roller and a molding die according to the present invention will be described in detail with reference to the accompanying drawings.

1 and 2 are a perspective view and an exploded perspective view of a microneedle roller according to an embodiment of the present invention.

1 and 2, the microneedle roller 10 of the present invention includes a roller head 11 and a roller handle 41. A plurality of microneedles 25 are formed in the roller head 11, and the roller handle 41 is coupled to both sides of the roller head 11.

The roller head 11 is cylindrical and has a wheel-shaped cut end surface in which the fan-shaped through-hole 19 was formed. As a result, the volume of the roller head 11 is reduced, so that the thermal influence is reduced, thereby preventing thermal deformation in the molding process.

On both sides of the roller head 11, the fitting protrusion 15 having the rotation shaft coupling groove 13 for engaging the roller handle 41 is formed at the center portion. The fitting protrusion 15 and the rotation shaft coupling groove 13 are provided for engagement with the roller handle 41 and smooth rotation. Here, the rotation shaft coupling groove 13 may be replaced by a through hole formed to penetrate the roller head 11. In addition, it is possible to have a variety of coupling structure within the range to enable the coupling with the handle 41 while enabling the rotation of the roller head (11).

On the outer circumferential surface of the roller head 11 is formed a conical micro needle 25 protruding from the surface. The roller head 11 and the microneedles 25 are integrally formed and formed of a polymer material, for example, polycarbonate (PC), polyetherimide (PEI), polymethylmethacrylate (PMMA), polyacetal (POM), polylatide (PLA), and polysulfone (PSU). Thermoplastic resins such as thermoplastic resins such as epoxy resins, phenol resins, and polyurethane resins. The roller head 11 on which the microneedles 25 are formed is manufactured by injection molding and press molding using a molding die described later. Here, the polymer resin may be composed of a biodegradable polymer such as PLA (Polylatide) or PLGA (Poly lactic-co-glycolic acid). This is because when the microneedles 25 remain in the skin, they are harmless to the human body and can be decomposed quickly.

The microneedles 25 protrude to a certain height from the outer circumferential surface of the roller head 11. The protruding height of the microneedle 25 may vary depending on the intended use. For example, when the microneedles 25 form a channel penetrating the epidermal layer to reach the dermal layer, the protruding height of the microneedles 25 is formed within 200 μm or more and 750 μm. Typically, the height of the microneedles 25 may be determined within a range of 20 μm to 2000 μm, but may be set out of this range as necessary.

On the other hand, the microneedles 25 may form heat at uniform intervals in the roller head 11. Thereby, uniform channel distribution can be formed in a specific area of the skin. It is desirable to narrow the gap between the rows formed by the microneedles 25 in the roller head 11 as much as possible. This is because the microneedles 25 can form a large number of channels in a specific area of skin. Here, the microneedles 25 may have various shapes other than the cone shape.

The roller handle 41 is divided into a U-shaped roller head engaging portion 43 and a handle portion 47 connected thereto. The roller head engaging portion 43 has two clamp arms 44. And each clamp arm 44 has a rotating shaft projection 45 to be used as the rotating shaft of the roller head (11). Two rotary shaft protrusions 45 formed to face each other are engaged by being fitted in the rotary shaft engaging groove 13 of the fitting protrusion 15 of the roller head 11. The clamp arms 44 facing from the roller head engaging portion 43 are configured to have a material or structure that allows them to spread apart. Accordingly, the roller head 11 and the roller handle 41 can be easily combined and separated by spreading the clamp arm 44. Here, the roller handle 41 may have a variety of other forms as long as it is a shape suitable for handling by the user while fixing and rotating the roller head 11.

3 and 4 are a perspective view and an exploded perspective view showing a micro-needle roller forming mold according to the present invention, Figures 5 to 7 is a perspective view showing the needle block, the coupling state of the lower plate base, lower plate base and the inner mold of Figure 4 .

3 and 4, the microneedle roller forming mold 100 of the present invention includes a lower plate base 110, an upper plate base, an inner mold 170, and an outer mold 150. Meshes to form an internal space for forming the microneedle roller 10 of FIG. 1 described above. The lower plate base 110, the upper plate base, the inner mold 170, and the outer mold 150 are all made of a metal material.

The lower plate base 110 and the upper plate base 130 have a disc shape. The lower plate base 110 and the upper plate base 130 are formed to have a size capable of sealing a cylindrical space in a state in which the needle blocks 151 to be described later are in close contact. Here, the lower plate base 110 and the upper plate base 130 is formed in the same size or larger than the side of the outer mold 150 is in the engaged state.

The outer mold 150 is divided into a plurality of needle block 151 formed in a fan shape cut a predetermined length from the inner end. Each needle block 151 is disposed in an annular shape and is configured to be movable inward and outward in the injection molding equipment. The needle blocks 151 are moved inward to form a cylindrical inner space as the side surfaces are in close contact with each other.

Each needle block 151 has a plurality of micro-needle forming grooves 153 formed to have a predetermined depth intaglio on the inner surface. The microneedle forming grooves 153 are formed in a row.

The more needle blocks 151 constituting the outer mold 150, the better. Too many needle blocks 151 may be difficult to fabricate and too little may be difficult to form a large number of microneedles. The microneedle-shaped grooves 153 may be formed by a plurality of rows of one needle block 151 to increase the number of microneedles. It is preferable that it consists of 4-30 pieces normally.

As shown in FIG. 5, an annular groove 111 is formed from an inner side surface of the lower plate base 110. The same applies to the upper base 130. An inner central portion of the outer mold 150 is formed with an annular groove 111 for forming a rotation shaft coupling groove (13 in FIG. 2) in the microneedle roller (10 in FIG. 2) described above. Here, instead of the annular groove 111, it is also possible to form a rod shape that is formed to cross the inner mold (170).

Like the outer mold 150, the inner mold 170 is a fan-shaped shape cut a predetermined length from the inner end, it is divided into a plurality of holes forming block 170a. The short hole forming block 170a may have a smaller size than the needle block 151 of the outer mold 150 so as to be located inside the outer mold 150. When the needle block 151 is in close contact with each other to form a cylindrical space, the internal mold 170 is inserted therein to form a plurality of fan-shaped spaces (19 of FIG. 2). The inner mold 170 is fixed to any one of the lower plate base 110 and the upper plate base 130. Here, it is fixedly coupled to the lower plate base 110 as shown in FIG. The inner mold 170 may be integrally formed with the lower plate base 110 or the upper plate base 130. Alternatively, other fastening members may be used.

Referring to the operation, each needle block 151 constituting the outer mold 150 is moved inward to be in close contact with each other to form a cylindrical space, and the upper plate base 110 and the lower plate base 110 are external. It is in close contact with the upper and lower parts of the mold 150. At this time, the outer mold 150 is inserted into the cylindrical space, in which the polymer resin is filled into the outer mold 150. After a predetermined time, the molding mold 100 The separation process of the roller head (11 in Fig. 2) proceeds from the needle block 151. The needle block 151 is moved outward in the direction of the upper plate base 130 by the eject pin (not shown) on the lower plate base 110 side. This allows the microneedle roller head to be completed by separating and discharging without damaging the microneedle.

According to the microneedle roller and the molding die according to the present invention as described above, the needle and the roller head are easily manufactured integrally by one injection molding using a polymer material. As a result, mass production is easy and the manufacturing process is simple, thereby greatly reducing the manufacturing cost. In addition, since the manufacturing cost is low, the rest of the roller handle may be used for single use in consideration of safety. It is advantageous to ensure safety for the use of the microneedle roller.

In addition, according to the microneedle roller and the molding die according to the present invention, since the microneedle can be manufactured by the injection molding process, the distance between the microneedle can be reduced compared to the conventional.

Claims (8)

Cylindrical roller head 11; A plurality of microneedles 25 protruding from an outer circumferential surface of the roller head 11; And A roller handle 41 to which the roller head 11 is rotatably coupled; Including; The roller needle (11) and the microneedle roller is a microneedle roller, characterized in that formed of a polymer resin material and integrally formed with each other. The method of claim 1, The polymer needle is a microneedle roller, characterized in that any one of a thermosetting resin and a thermoplastic resin. The method of claim 1, Microneedle roller, characterized in that the polymer resin is a biodegradable polymer. The method of claim 1, The roller handle 41 has a roller head engaging portion 43 comprising two clamp arms 44 each having a rotational shaft projection 45, The roller head (11) is a microneedle roller, characterized in that it has a rotation shaft coupling groove (13) to which the rotation shaft projection (45) is coupled. It has a plurality of needle block 151 having a plurality of micro-needle forming grooves 153 formed on the inner side and the needle blocks 151 are arranged in an annular shape to be in close contact when moving inward to form a cylindrical inner space An outer mold 150; A lower plate base 110 having a disc shape covering a lower portion of the outer mold 150 while the needle blocks 151 are in close contact with each other; And An upper plate base 130 having a disc shape covering an upper portion of the outer mold 150 while the needle blocks 151 are in close contact with each other; Micro-needle roller forming mold comprising a. The method of claim 5, The hole forming block is fixed to any one of the lower plate base 110 and the upper plate base 130 and inserted into the needle block 151 to form a cylindrical shape when the needle blocks 151 are in close contact with each other to form a cylinder. The microneedle roller forming mold, further comprising an inner mold 170 having a 170a. The method of claim 5, The outer mold 150 has a micro needle roller molding mold, characterized in that it has 4 to 30 needle blocks (151). The method of claim 5, The upper plate base 130 and the lower plate base 110 is a microneedle roller forming mold, characterized in that an annular groove 111 is formed for the rotation axis coupling.

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