KR100715781B1 - Antibiotic filter having antibiotic pulp carrying aromatic antibiotic compounds - Google Patents

Abstract

The present invention relates to an antimicrobial filter using an antibacterial pulp supported by an aromatic antimicrobial composition, and more particularly, one or more essential oils containing essential oils of cassia and selected from the group consisting of bergamot, marjoram, phytoncide, thyme, lavender, and eucalyptus. It has excellent antibacterial and antifungal power, and provides an antimicrobial filter with antibacterial pulp as an excellent carrier material. It is excellent in antimicrobial sustainability because it keeps releasing continuously, its manufacturing method is simple and its durability and robustness are excellent. It is especially preferable for antibacterial use of various telephones.

Description

Antibiotic filter having antibacterial pulp supported by aromatic antimicrobial composition

1 is an overall plan view and a side cross-sectional view of a directional antibacterial filter according to the present invention.

2 is a plan view and a side view of the main body.

3 is a plan view and a side view of the antimicrobial nonwoven fabric.

4 is a plan view and a side view of the top cover.

5 is a plan view and a side cross-sectional view of the antibacterial pulp.

6 is a plan view and a side view of the undercover;

<Description of the symbols for the main parts of the drawings>

1: upper cover 2: antibacterial nonwoven fabric

3: body 4, 5: antibacterial pulp

6: lower cover

The present invention relates to an antibacterial filter having excellent antibacterial and antifungal power, and in particular an aromatic antimicrobial composition with excellent antibacterial and antifungal action due to the emitted fragrance.

Conventional antimicrobial agents are mostly composed of synthetic fungicides, causing side effects to the human body, and especially when used in a confined space or adjacent to the skin or respiratory tract, causing various side effects such as headaches, allergies, and skin spots.

Meanwhile, Korea Public Telephone Co., Ltd., a public corporation that was in charge of the public telephone business and management of Korea, began disinfecting telephones using a disinfectant called tegoji, an imported drug, in the early 1990s. However, Tegoji is suspected of having a short duration and corroding the speaker inside the handset.

In order to solve this problem of synthetic fungicides, research on natural fragrances harmless to the human body has been actively conducted.

Conventional techniques for solving this problem include the "natural antimicrobial composition of the antimicrobial and antifungal action" of the application No. 10-1998-0021257 and the "natural flavor material" of the application No. 10-1999-0009857 Containing disinfectant composition "and" Antimicrobial filter for telephone and its manufacturing method "of the previously filed application No. 10-2000-0021336.

Essential oil composition with antimicrobial and antitumor activity of Application No. 10-1998-0021257 is i) 0.1-99.9% by weight of oregano and ii) dill, lavender, lemon balm, rosemary, mint, ivory, sage, cented geranium, self-heel , Sweet basil, chervil, thyme, tanji, cinnamon, clove, eucalyptus, lemon, peppermint and tea tree is composed of 0 to 99.9 wt% of essential oils.

In addition, the disinfectant composition containing the natural flavoring material of Application No. 10-1999-0009857 is one or more natural flavoring materials selected from lemongrass oil, cumin oil, marjoram oil, basil oil, clover oil and bay oil. It is characterized by consisting of.

In order to use the composition consisting of vegetable essential oils for the actual antibacterial purpose, the antimicrobial effect should be excellent, the antimicrobial activity lasts long, and the sensory evaluation should be recognized as excellent. This will vary considerably depending on which oil is used and in what proportion.

By the way, in the antimicrobial effect test in the antimicrobial effect test, using the paper disk method of Maruzel in direct contact with the test fragrance and microorganisms, although the typical bacteria that can be propagated, E. coli, Staphylococcus aureus, Pseudomonas aeruginosa, There is a problem that the effect is not great.

In particular, it is skeptical in practical use because of the problem of not being able to suppress the propagation of microorganisms in the part which is not in direct contact with the antimicrobial composition carrier and the doubt about the persistence of the antibacterial activity.

In addition, in the case of the antimicrobial filter for a telephone of the applicant previously filed No. 10-2000-0021336, the antimicrobial agent is particularly applied to the telephone, but the antimicrobial nonwoven fabric is attached to the antimicrobial resin in its manufacture. When melted at a high temperature when the antimicrobial composition is destroyed, such as a loss occurs, even when attached with an adhesive, there is a problem that it is eliminated and deformed due to heat or moisture and other causes.

The present inventors have conducted research in order to solve the above problems, the antibacterial filter having excellent antibacterial and antifungal power, in particular an aromatic antimicrobial composition with excellent antibacterial and antifungal action due to the scent emitted without direct contact It has been developed, the antimicrobial filter is not a deterioration effect of the sterilization effect and keeps the release of the antimicrobial composition continuously and its manufacturing method is simple and excellent durability and robustness, especially suitable for the antibacterial use of various telephones.

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The present invention is an antibacterial pulp containing an aromatic antimicrobial composition containing 1 to 99% by weight of essential oil of cassia and 1 to 99% by weight of one or more essential oils selected from the group consisting of bergamot, marjoram, thyme, lavender and eucalyptus, The main body accommodating the antimicrobial pulp inside, the lower cover for fixing the antimicrobial pulp and covering the antimicrobial pulp, antimicrobial non-woven fabric placed on top of the main body, the anti-microbial non-woven fabric that is configured as a ring-shaped upper cover It consists of a directional antibacterial filter characterized by.

In another aspect, the present invention is characterized in that the aromatic antimicrobial composition contains all the essential oils of cassia, bergamot, lavender, eucalyptus and thyme, the weight percent of each of 20%: 28%: 33%: 12%: 7% It consists of aromatic antibacterial filter.

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The present invention, in addition to the above-described configuration, the main body is a cross-linked currency sphere, the antimicrobial composition is slowly released, a plurality of small vents, the upper cover and the lower cover for easy long-term antimicrobial effect combined easily and simply It consists of a directional antimicrobial filter, characterized in that it further comprises a plurality of protruding portion to protrude.

According to still another aspect of the present invention, there is provided the above-mentioned directional antibacterial filter, which is used for handsets of various telephones.

Hereinafter, with reference to the experimental examples and examples of the present invention will be described in more detail.

In order to develop a fragrance antimicrobial filter excellent antimicrobial effect in the present invention was selected as Cassia, bergamot, marjoram, thyme, lavender, eucalyptus as the test flavoring material and tested the antimicrobial activity as in Experimental Example 1, the result of the growth-lowering ring The size is shown in Table 1. As shown in Table 1, the antibacterial and antifungal activity of Cassia was superior to any other fragrances, and particularly, it was found that the antibacterial activity against E. coli, Staphylococcus aureus, and Pseudomonas aeruginosa was significantly superior to conventionally known antibacterial fragrances.

In addition, since the present invention is to develop a fragrance applied antimicrobial filter to suppress the growth of microorganisms through the emitted fragrance was tested as in Experimental Example 2 to measure the antimicrobial power due to the emitted fragrance of the test perfume. That is, in the same manner as in Experimental Example 1, but without placing the paper disk on the medium, the Petri dish was turned upside down in the center of the lid and then dropping the fragrance so that the antimicrobial action by the emitted odor without contacting the microorganisms. The size of the resulting growth-lowering ring is shown in Table 2. As shown in Table 2, the vaporizing antimicrobial activity of Cassia was superior to any other fragrances and was comparable to or superior to that of other fragrances measured by contact in Experimental Example 1.

In addition, the present invention relates to an antimicrobial filter applied to the aromatic antimicrobial composition having a sterilizing effect while removing odor and releasing a sensual scent, since the fragrance and sterilization power of the natural perfume substance is changed according to the type and composition ratio of the present invention. In order to develop and provide an aromatic antimicrobial composition having a preferred composition ratio that meets the purpose, the antimicrobial activity was tested as in Experimental Example 3 by constructing an aromatic antimicrobial composition as in Examples 1 to 6. However, the embodiment is only for illustrating the invention in more detail, and is not intended to limit or limit the scope of the present invention, the composition and composition ratio of the antimicrobial composition may vary according to the preference of the individual.

The results of Experimental Example 3 are shown in Table 3. As shown in Table 3, the aromatic antimicrobial composition of Example 5 was found to have the best antimicrobial activity, and in particular, it was found to have excellent antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and E. coli compared to the prior art. Also in view of functionality, the composition of Example 5 is preferred.

In order to be preferably applied to the antimicrobial filter of the present invention, in order to develop a carrier material capable of evaporating at an appropriate rate while containing a large amount of fragrance in a narrow space as much as possible, nine kinds of carrier materials were selected and tested as in Experimental Example 4. The results are shown in Table 4. As shown in Table 4, it was confirmed that after 4 weeks, the pulp was significantly superior in functionality and persistence of antimicrobial activity.

The present invention maintains the release of the antimicrobial composition without the phenomenon of degradation of the bactericidal effect, the manufacturing method is simple and excellent durability and robustness, and particularly relates to the aromatic antimicrobial filter preferred for the antimicrobial use of the phone, the fragrance of the above A main body accommodating antimicrobial pulp, a lower cover for fixing the antimicrobial pulp and covering the antimicrobial pulp, an antimicrobial nonwoven fabric placed on top of the main body, characterized in that it consists of an upper cover of the open shape in the center to fix the antimicrobial nonwoven fabric. It is done.
Preferred embodiments of the antimicrobial filter will be described in detail with reference to the accompanying drawings.

As shown in FIG. 1, the aromatic antimicrobial filter includes an upper cover 1, an antimicrobial nonwoven fabric 2, a main body 3, an antimicrobial pulp 4, 5, and a lower cover 6 supported by an aromatic antimicrobial composition. Will be.

As shown in FIG. 2, the main body 3 includes a sealed space for accommodating the antimicrobial filter supported by the aromatic antimicrobial composition inside the main body. In addition, the communication sphere is formed in the center so as not to degrade the call quality of the phone, it is preferable to connect the inside of the communication sphere in a cross shape for durability. The call sphere and the receiving space are separated from each other so that the antimicrobial composition is not released through the call sphere, and the antimicrobial composition is gradually symmetrically provided with a plurality of small vents (four in Fig. 2) in the main body so that the antimicrobial effect is released. do.

In addition, it is preferable that the upper cover 1 and the lower cover 6 can be easily and simply coupled to the main body by providing a coupling part formed of a plurality of protrusions in the circumference and the central communication port of the main body 3, respectively. By having such a coupling portion, the body and the cover can be combined with one touch, so that the production of the antibacterial filter is easy and simple.

As shown in FIG. 3, the antimicrobial nonwoven fabric 2 is made of a thin film having a porosity and does not interfere with the quality of the call so that the inflow and outflow of air is easy, and the nonwoven fabric manufactured to the outer diameter of the upper cover 1 is Preferably, the aromatic antimicrobial composition may be supported. The antimicrobial nonwoven fabric 2 is placed on top of the body 3 and fixed by the top cover 1.

As shown in Figure 4, the upper cover 1 is preferably to have an antimicrobial nonwoven fabric coupled to the main body 3 and has an inner diameter of a size that does not seal the communication port and the vent of the main body is formed in an annular shape.

Antimicrobial pulp (4, 5), as shown in Figure 5, is manufactured to be accommodated inside the body in a ring shape, and to support the aromatic antimicrobial composition to gradually release the aromatic antimicrobial composition while maintaining the antimicrobial power for a long time As pulp it is preferred to use pulp. When the components of the antimicrobial composition are aqueous and oily, it is preferable to use two antimicrobial pulp respectively supported.

As shown in FIG. 6, the lower cover 6 has a communication port formed at the center thereof, but preferably, the inside of the communication port is cross-shaped for durability, and a plurality of protruding coupling parts are formed at one surface to be easily attached to the main body. In addition, it is desirable to make a plurality of small vents in order for the antimicrobial composition to be released slowly to have long-term antimicrobial effect.

The directional antibacterial filter can be used for the purpose of antibacterial of the handset of the telephone and is preferably processed to the size of the telephone handset lid.

As described above, the antimicrobial filter carrying the aromatic antimicrobial composition of Example 5 was prepared, and the antimicrobial activity of the aromatic antimicrobial filter was tested as in Experimental Example 5, and the antimicrobial power was not lowered even by the antimicrobial filter.

Hereinafter, the present invention will be described in more detail with reference to Examples and Experimental Examples. However, the following Examples and Experimental Examples are merely illustrative of the present invention and the present invention is not limited thereto.

Experimental Example 1 Antibacterial Activity of Perfume

In order to confirm the antimicrobial effect of the selected fragrance, the antimicrobial activity was tested using a conventional antimicrobial confirmation method.

As bacteria to be tested, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium were used as fungi. Saccharomyces cerevisiae, Candida albicans, Aspergillus niger, Aspergillus fumigatus, Penicillium roquefortii, Trichophyton Trichophyton rubrum and Epidermophyton floccosum were used.

As the growth medium of the test strain, nutrient agar was used for bacteria and its composition was as follows. 5 g of peptone and 3 g of bee extract were dissolved per 1 L of distilled water, and then the pH was adjusted to 7.4. The agar was added to 15 g and sterilized. For mold and yeast, malt extract agar was used and its composition was as follows. 6 liters of malt extract, maltose 1.8 g, glucose 6 g, and yeast extract 1.2 g per 1 liter of distilled water were dissolved. The pH was adjusted to 5.4, and 15 g of agar was added. It was added and sterilized. For athlete's foot fungi, Saburaud dextrose agar was used and its composition was as follows. 10 g of tryptone and 20 g of glucose were dissolved per 1 L of distilled water, and the pH was adjusted to 5.6, followed by sterilization with 20 g of agar.

For antimicrobial activity, all test strains were adjusted so that the concentration of feeder cells or spores pre-cultured beforehand was between 2 × 10 ⁶ colony forming units (CFU) / mL and 1 × 10 ⁷ colony forming units (CFU) / mL. 15% glycerol was added to phosphate buffered saline solution (PBS) solution was used in the test while storing in a -70 ℃ freezer.

Each test strain stock solution stored at low temperature for the measurement of antimicrobial activity was thawed rapidly in a 30 ° C. constant temperature water bath, and then added dropwise to 0.1 mL in a petri dish (85 mm diameter) containing a medium suitable for each test strain. Then, a paper disc (8 mm in diameter) was placed on the medium, and 30 μL of the test flavor was added dropwise, and the bacteria were incubated at 37 ° C. for 24 hours, and the fungi and athlete's foot fungus were incubated at 30 ° C. for 36 to 72 hours.

The antimicrobial activity of the combination of the fragrance and the flavor was determined by measuring the presence and the diameter of the growth zone (clear zone) caused by the growth of the tested strain is inhibited. Table 1 shows the size of growth-lowering ring formed as a result of the test.

[Table 1] Size of growth-lowering ring produced by the antibacterial effect of perfume

Test strain Size of growth low ring (mm) Cassia time lavender Marjoram Bergamot Eucalyptus Phytoncide Bacillus subtilis 48 25 17 29 19 15 16 Staphylococcus Oreus 65 27 20 39 27 16 23 Escherichia coli 50 16 12 23 15 10 10 Salmonella typhimurium 36 15 10 19 11 8 8 Pseudomonas Eruzinosa 27 15 9 12 9 8 10 Saccharomyces cerevisiae 85 50 19 46 20 12 50 Candida Albicans 85 50 19 48 18 13 56 Aspergillus Niger 80 47 23 31 22 20 57 Aspergillus fumigatus 82 47 27 27 25 27 59 Penicillium Roquefort 85 60 31 68 34 28 45 Tricophyton loverum 76 47 18 33 19 14 54 Epidermophyton Floco Island 71 47 15 41 16 10 50

Experimental Example 2 Measurement of Antimicrobial Activity by Emitted Aroma

The ultimate goal of the present invention is to inhibit the growth of microorganisms through evaporated perfume. In order to confirm this, the test was conducted in the same manner as in Test Example 1, but instead of placing the paper disk on the medium, the Petri dish was turned upside down, and the spices were dropped. Table 2 shows the size of the growth-lowering ring formed as a result of the test.

[Table 2] Size of growth-lowering ring produced by vaporization antibacterial method

Test strain Size of growth low ring (mm) Cassia time lavender Marjoram Bergamot Eucalyptus Phytoncide Bacillus subtilis 39 19 8 10 5 3 12 Staphylococcus Oreus 42 20 14 20 13 8 13 Escherichia coli 28 9 8 8 3 3 7 Salmonella typhimurium 21 8 5 7 3 0 10 Pseudomonas Eruzinosa 16 8 3 4 0 0 8 Saccharomyces cerevisiae 67 40 16 15 10 5 35 Candida Albicans 60 40 15 15 7 3 33 Aspergillus Niger 59 31 12 20 6 7 27 Aspergillus fumigatus 74 32 13 25 7 7 42 Penicillium Roquefort 81 60 30 27 15 10 41 Tricophyton loverum 45 39 14 16 7 3 37 Epidermophyton Floco Island 49 32 13 15 6 3 31

[Test Example 3]. Determination of antimicrobial activity by combination of flavors

The antimicrobial activity was tested by mixing the composition of the present invention in a weight% ratio with the same composition as in the following examples, and the results of the antimicrobial test by applying them are shown in Table 3.

<Example 1>

Eucalyptus 20%, Cassia 28%, Lavender 34%, Phytoncide 18%

<Example 2>

Eucalyptus 18%, Marjoram 35%, Bergamot 30%, Phytoncide 17%

<Example 3>

10% thyme, 27% cassia, 35% marjoram, 28% bergamot

<Example 4>

12% of thyme, 36% of lavender, 28% of marjoram, phytoncide 24%

Example 5

Eucalyptus 12%, thyme 7%, cassia 20%, lavender 33%, bergamot 28%

<Example 6>

Eucalyptus 15%, Time 8%, Marjoram 27%, Bergamot 35%, Phytoncide 15%

TABLE 3 Size of growth-lowering ring of the composition

Test strain Size of growth low ring (mm) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Bacillus subtilis 14 8 19 11 27 17 Staphylococcus Oreus 31 16 24 19 43 22 Escherichia coli 10 4 12 5 21 13 Salmonella typhimurium 9 0 7 3 18 8 Pseudomonas Eruzinosa 5 0 7 0 14 6 Saccharomyces cerevisiae 39 27 51 36 58 35 Candida Albicans 44 25 53 25 64 38 Aspergillus Niger 49 27 38 44 69 52 Aspergillus fumigatus 47 32 43 39 71 57 Penicillium Roquefort 40 41 53 52 78 68 Tricophyton loverum 61 47 38 48 80 63 Epidermophyton Floco Island 68 42 41 43 80 67

Experimental Example 4 Performance Experiment of Carrier Material

The development of a carrier which can evaporate at a suitable rate while containing as much perfume as possible in a narrow space is one of the most important factors in the present technical development task. Candidates that could be used as carriers were placed in the inner empty space of the plastic body, absorbed as much of the flavor mixture as possible, and the antimicrobial nonwoven fabric was fixed to produce a prototype and installed in a real public telephone. After 4 weeks, the intensity of the remaining fragrance was recovered by sensory evaluation (5-point method). The antimicrobial activity of 7 microorganisms was measured by vaporization antibacterial method and the results are shown in Table 4.

Table 4. Results of Persistence and Antimicrobial Activity of Carrier Candidates

  Substance Incense intensity Size of growth low ring (mm) S. aureus B. subtilis E. coli p. aeruginosa S. cerevisiae A. niger P. roquefortii silica gel 1.1 0 0 0 0 0 0 0 zeolite 1.0 0 0 0 0 0 0 0 paraffin 3.4 5 2 0 0 9 10 18 cyclodextrin 2.1 5 0 0 0 7 5 8 pulp (thick) 3.7 26 19 14 6 39 40 61 pulp (thin) 2.8 11 4 0 0 15 15 20 methyl paraben 1.4 0 0 0 0 0 0 0 carraginan 2.2 3 0 0 0 0 0 0 Ca-alginate 1.6 3 0 0 0 10 0 4

Experimental Example 5 Antibacterial Activity of Antibacterial Filter

The antimicrobial activity was investigated by preparing a directional antimicrobial filter according to the composition of Example 5, which was found to be the best antimicrobial and functional properties. In order to verify the antimicrobial activity proceeded in the same manner as in Test Example 2, instead of the paper disk was used a directional antibacterial filter. The results of testing the antimicrobial activity of the aromatic antimicrobial filter are shown in Table 5.

[Table 5] Size of growth low ring produced by antibacterial activity of antibacterial filter

Test strain Size of growth low ring (mm) Bacillus subtilis 85 Staphylococcus Oreus 52 Escherichia coli 45 Salmonella typhimurium 35 Pseudomonas Eruzinosa 30 Saccharomyces cerevisiae 52 Candida Albicans 72 Aspergillus Niger 80 Aspergillus fumigatus 85 Penicillium Roquefort 85 Tricophyton loverum 56 Epidermophyton Floco Island 45

The aromatic antimicrobial composition to be applied to the present invention exhibits excellent antibacterial and antifungal effects against various bacteria, molds and yeasts, and in particular, the antimicrobial activity due to vaporized flavor is remarkably excellent, and the aromatic antimicrobial filter to which the composition is applied is easy to manufacture. It is durable and at the same time, it has excellent antibacterial and functional properties and has excellent antibacterial persistence.

Claims (6)

delete delete delete Antibacterial pulp supported by an aromatic antimicrobial composition composed of 1 to 99% by weight of essential oil of cassia and 1 to 99% by weight of at least one essential oil selected from the group consisting of bergamot, marjoram, thyme, lavender, and eucalyptus; A main body accommodating the antibacterial pulp inside; A lower cover fixing the antibacterial pulp and covering the antibacterial pulp; Antimicrobial nonwoven fabric placed on top of the body; And Ring-shaped upper cover for fixing the antimicrobial nonwoven fabric Directional antibacterial filter, characterized in that configured. The method of claim 4, wherein the main body is a cross-shaped communication port in the center, the antimicrobial composition is gradually released to a plurality of small vents for long-term antimicrobial effect, protruding to easily and easily combine the upper cover and the lower cover Directional antimicrobial filter, characterized in that it further comprises a plurality of coupling parts. The directional antimicrobial filter according to claim 4 or 5, wherein the directional antimicrobial filter is mounted on the handset of the telephone.

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