KR100497423B1

KR100497423B1 - 다기능 키메라 조혈 수용체 아고니스트

Info

Publication number: KR100497423B1
Application number: KR10-1999-7003635A
Authority: KR
Inventors: 맥훼어터찰즈에이.; 펑이칭; 매컨존피.; 섬머스니나엘.; 스태튼니콜라스알.; 스트리터필립알.; 미널리존시.; 민스터낸시아이.; 울프수잔엘.
Original assignee: 지.디. 썰 엘엘씨
Priority date: 1996-10-25
Filing date: 1997-10-23
Publication date: 2005-07-07
Also published as: JP2001504689A; AR010041A1; EP0935663A2; IL129565A0; TW200413407A; ZA979607B; KR20000052812A; RO120919B1; WO1998017810A2; NO991948L; WO1998017810A3; PL333023A1; AU725547B2; TW591035B; RU2005105360A; CZ132399A3; CA2268742A1; RU2245887C2; NZ335382A; BR9713668A

Abstract

새로운 다기능 키메라 조혈 수용체 아고니스트 단백질, 다기능 키메라 조혈 수용체 아고니스트 단백질을 암호화하는 DNA, 다기능 키메라 조혈 수용체 아고니스트 단백질의 제조방법 및 다기능 키메라 조혈 수용체 아고니스트 단백질의 사용방법이 개시되어 있다.

Description

다기능 키메라 조혈 수용체 아고니스트{MULTI-FUNCTIONAL CHIMERIC HEMATOPOIETIC RECEPTOR AGONISTS}

본 발명은 다기능 키메라 조혈 수용체 아고니스트에 관한 것이다. 이들 다기능 키메라 조혈 수용체 아고니스트는 키메라 분자의 각 성분의 한가지 이상의 활성을 보유하고, 또한 개선된 조혈세포자극활성 및/또는 각 조혈성장인자와 관련된 바람직하지 않은 생물학적 활성의 감소를 포함하는 개선된 활성 프로파일을 나타낼 수 있고, 그리고/또는 증가된 용해도, 안정성 및 재폴딩효율을 포함하는 개선된 물리적 성질을 가질 수 있다.

골수 세포의 분화 및/또는 증식을 자극하는 콜로니자극인자(CSF)는 조혈 간세포에 유래하는 세포의 저하된 레벨을 회복시키는 치료적 잠재력 때문에 많은 관심을 불러일으켜 왔다. 사람 및 쥐 계통 양자에서의 CSF가 동정되었고 그들의 활성에 따라 구별되었다. 예를 들어 과립구-CSF(G-CSF) 및 대식세포-CSF(M-CSF)는 각각 호중성 과립구 콜로니 및 대식세포 콜로니의 시험관내 형성을 자극하는 한편, GM-CSF 및 인터루킨-3(IL-3)은 더 광범위한 활성을 갖고 대식세포 콜로니와 호중성 및 호산성 과립구 콜로니 양자의 형성을 자극한다. IL-3은 또한 마스트 콜로니, 거핵구 콜로니 그리고 순수 및 혼합 적혈구 콜로니의 형성을 자극한다.

미국 특허 제4,877,729호 및 미국 특허 제4,959,455호에는 기번 IL-3 cDNA 및 추측된 사람 IL-3 DNA 서열과 이들이 암호화하는 단백질 서열이 개시되어 있다. 개시된 hIL-3은 단백질 서열의 위치 8에 프롤린 대신 세린을 갖는다.

국제특허출원(PCT) WO 88/00598에는 기번 및 사람 유사 IL-3이 개시되어 있다. 이 hIL-3은 Ser⁸ → Pro⁸ 치환을 함유한다. Cys를 Ser로 치환하여 이황화 다리를 절단하는 것과 글리코실화 부위에서 한 개 이상의 아미노산을 치환하는 것이 제안되었다.

미국 특허 제4,810,643호에는 사람 G-CSF를 암호화하는 DNA 서열이 개시되어 있다.

WO 91/02754에는 GM-CSF 또는 IL-3 단독과 비교하여 증가된 생물학적 활성을 갖는 GM-CSF 및 IL-3으로 이루어진 융합 단백질이 개시되어 있다. 또한 다기능 키메라 조혈 수용체 아고니스트의 성분으로서 비글리코실화된 IL-3 및 GM-CSF 유사 단백질도 개시되어 있다.

WO 92/04455에는 IL-3, IL-6, IL-7, IL-9, IL-11, EPO 및 G-CSF로 이루어지는 군으로부터 선택된 림포카인에 융합된 IL-3으로 구성된 융합 단백질이 개시되어 있다.

WO 95/21197 및 WO 95/21254에는 광범위한 다기능성 조혈 특성을 가질 수 있는 융합 단백질이 개시되어 있다.

영국 특허 제2,285,446호는 혈소판감소증의 치료에 사용될 수 있는 거핵구 및 거핵구 전구체의 복제, 분화 및 성숙에 영향을 미치는 것으로 밝혀진 c-mpl 리간드(트롬보포이에틴) 및 각종 형태의 트롬보포이에틴에 관한 것이다.

EP 675,201 A1은 c-mpl 리간드(거핵구 성장 및 발생 인자(MGDF)), c-mpl 리간드의 대립유전자 변이체 및 폴리에틸렌글리콜과 같은 수용성 중합체에 부착된 c-mpl 리간드에 관한 것이다.

WO 95/21920은 쥐 및 사람 c-mpl 리간드 및 그것의 폴리펩티드 단편을 제공하고 있다. 이 단백질은 혈소판 생성을 자극하기 위한 생체내 및 생체외 요법에 유용하다.

린, 에프-케이.(Lin, F-K.)의 미국 특허 제4,703,008호에는 에리트로포이에틴을 암호화하는 cDNA 서열, 에리트로포이에틴의 제조방법 및 사용이 개시되어 있다.

WO 91/05867에는 EPO(Asn⁶⁹), EPO(Asn¹²⁵, Ser¹²⁷), EPO(Thr¹²⁵) 및 EPO(Pro¹²⁴, Thr¹²⁵)와 같은, 사람 에리트로포이에틴보다 더 많은 수의 탄수화물부착부위를 갖는 사람 에리트로포이에틴 유사체가 개시되어 있다.

WO 94/24160에는 향상된 활성을 갖는, 구체적으로 위치 20, 49, 73, 140, 143, 146, 147 및 154에서 아미노산 치환을 갖는 에리트로포이에틴 뮤테인이 개시되어 있다.

WO 94/28391에는 천연 flt3 리간드 단백질 서열 및 flt3 리간드를 암호화하는 cDNA 서열, cDNA로 트랜스펙션된 숙주세포에서 flt3 리간드를 발현시키는 방법 및 flt3 리간드를 사용하여 조혈성 장애가 있는 환자를 치료하는 방법이 개시되어 있다.

미국 특허 제5,554,512호는 분리된 단백질로서의 사람 flt3 리간드, flt3 리간드를 암호화하는 DNA, flt3 리간드를 암호화하는 cDNA로 트랜스펙션된 숙주세포 및 flt3 리간드로 환자를 치료하는 방법에 관한 것이다.

WO 94/26891은 29 아미노산의 삽입체를 갖는 분리물을 포함하는 포유동물 flt3 리간드 및 그것의 단편을 제공하고 있다.

단백질 서열의 재배열

진화에 있어서, DNA 서열의 재배열은 단백질 구조 및 기능의 다양성을 초래하는데 있어서 중요한 역할을 한다. 유전자 복제 및 엑손 셔플링은 특히 기본 돌연변이율이 낮기 때문에 다양성을 신속히 초래하는 중요한 메카니즘을 제공함으로써 경합적 이점을 갖는 생물체를 제공한다(Doolittle, Protein Science 1:191-200, 1992).

재조합 DNA법의 개발로 단백질 폴딩, 구조 및 기능에 미치는 서열 전위의 영향을 연구하는 것이 가능하게 되었다. 새로운 서열을 만드는데 사용되는 접근법은 관련된 자연발생 단백질쌍을 아미노산 서열의 선형 재구성에 의해 만드는데 사용되는 것과 유사하다(Cunningham, et al., Proc. Natl. Acad. Sci. U.S.A. 76:3218-3222, 1979; Teather & Erfle, J. Bacteriol. 172: 3837-3841, 1990; Schimming et al., Eur. J. Biochem. 204: 13-19, 1992; Yamiuchi and Minamikawa, FEBS Lett. 260:127-130, 1991; MacGregor et al., FEBS Lett. 378:263-266). 단백질에 이러한 유형의 재배열을 최초로 시험관내에서 적용한 것이 골덴버그(Goldenberg) 및 크레이톤(Creighton)(J. Mol. Biol. 165:407-413, 1983)에 의해 기재되었다. 새로운 N-말단이 원래 서열의 내부 부위(절단점)에서 선택되고, 새로운 서열은 원래의 C-말단에 있거나 또는 그 부근에 있는 아미노산에 이를 때까지 절단점으로부터 원래의 것과 동일한 순서의 아미노산을 갖는다. 이 때 새로운 서열은 원래의 N-말단에 있거나 또는 그 부근에 있는 아미노산에 직접 또는 서열의 추가 부분(링커)을 통해 결합되고, 새로운 서열은 원래 서열의 절단점 부위에 대해 N-말단이었던 아미노산에 있거나 또는 그 부근에 있는 지점에 이를 때까지 원래의 것과 동일한 서열을 계속 갖고, 이 잔기는 사슬의 새로운 C-말단을 형성한다.

이 접근법은 크기가 58 내지 462 아미노산의 범위인 단백질에 적용되어 왔다 (Goldenberg & Creighton, J. Mol. Biol. 165:407-413, 1983; Li & Coffino, Mol. Cell. Biol. 13:2377-2383, 1993). 조사된 단백질은 a-헬릭스(인터루킨-4; Kreitman et al., Cytokine 7:311-318, 1995), b-시트(인터루킨-1; Horlick et al., Protein Eng. 5:427-431, 1992), 또는 이 두가지의 혼합물(효모 포스포리보실 안트라닐레이트 이소머라제; Luger et al., Science 243:206-210, 1989)을 주로 함유하는 단백질을 포함하여 광범위한 범위의 구조 등급을 나타내었다. 다음과 같은 광범위한 범주의 단백질 기능이 이러한 서열 재구성 연구에서 나타났다.

효소

T4 리소짐 Zhang et al., Biochemistry 32:12311-

12318, 1993; Zhang et al., Nature Struct. Biol. 1:434-438, 1995

데히드로폴레이트 리덕타제 Buchwalder et al., Biochemistry

31:1621-1630, 1994; Protasova et

al., Prot. Eng. 7:1373-1377, 1995

리보뉴클레아제 T1 Mullins et al., J. Am. Chem. Soc. 116:5529-5533, 1994; Garrett et al., Protein Science 5:204-211, 1996

바실러스 b-글루카나제 Hahn et al., Proc. Natl. Acad. Sci. U.S.A. 91:10417-10421, 1994

아스파르테이트 트랜스 Yang & Schachman, Proc. Natl. Acad.

카르바모일라제 Sci. U.S.A. 90:11980-11984, 1993

포스포리보실 안트라닐레이트 Luger et al., Science 243:206-210, 1989;

이소머라제 Luger et al., Prot. Eng. 3:249-258, 1990

펩신/펩시노겐 Lin et al., Protein Science 4:159-

166, 1995

글리세르알데히드-3-포스페이트 Vignais et al., Protein Science

데히드로게나제 4:994-1000, 1995

오르니틴 데카르복실라제 Li & Coffino, Mol. Cell. Biol.

13:2377-2383, 1993

효모 포스포글리세레이트 Ritco-Vonsovici et al., Biochemistry

데히드로게나제 34:16543-16551, 1995

효모 저해제

염기성 췌장 트립신 저해제 Goldenberg & Creighton, J. Mol. Biol.

165:407-413, 1983

시토카인

인터루킨-1b Horlick et al., Protein Eng. 5:427-

431, 1992

인터루킨-4 Kreitman et al., Cytokine 7:311-

318, 1995

티로신 키나제 인식 도메인

a-스펙트린 SH3 도메인 Viguera, et al., J. Mol. Biol. 247:670-681, 1995

트랜스멤브레인 단백질

omp A Koebnik & Kramer, J. Mol. Biol. 250:617-626, 1995

키메라 단백질

인터루킨-4－Pseudomonas 엑소톡신 Kreitman et al., Proc. Natl. Acad.

Sci. U.S.A. 91:6889-6893, 1994

이들 연구의 결과는 아주 가변적이었다. 많은 경우에, 실질적으로 낮은 활성, 용해도 또는 열역학적 안정성이 관찰되었다(E. coli 디히드로폴레이트 리덕타제, 아스파르테이트 트랜스카르바모일라제, 포스포리보실 안트라닐레이트 이소머라제, 글리세르알데히드-3-포스페이트 데히드로게나제, 오르니틴 데카르복실라제, omp A, 효모 포스포글리세레이트 데히드로게나제). 다른 경우에는, 서열 재배열된 단백질이 그것의 천연 대응물과 거의 동일한 성질을 많이 갖는 것으로 나타났다(염기성 췌장 트립신 저해제, T4 리소짐, 리보뉴클레아제 T1, 바실러스 b-글루카나제, 인터루킨-1b, a-스펙트린 SH3 도메인, 펩시노겐, 인터루킨-4). 예외적인 경우에는, 천연 서열의 일부 성질을 능가하는 예기치 않은 개선, 예를 들면 재배열된 a-스펙트린 SH3 도메인 서열에 대해서는 용해도 및 재폴딩율, 전위된 인터루킨-4－Pseudomonas 엑소톡신 융합 분자에 대해서는 수용체 친화성 및 항종양 활성의 개선이 관찰되었다(Kreitman et al., Proc. Natl. Acad. Sci. U.S.A. 91:6889-6893, 1994; Kreitman et al., Cancer Res. 55:3357-3363, 1995).

이러한 유형의 연구를 하게 된 주요 동기는 단백질 폴딩 및 안정성에 있어서의 단기적 및 장기적 상호작용의 역할을 연구하는 것이었다. 이러한 유형의 서열 재배열은 원래 서열에서의 장기적인 상호작용 서브세트를 새로운 서열에서의 단기적인 상호작용으로 전환시키고, 또 그 반대로도 전환시킨다. 이들 서열 재배열의 다수가 적어도 약간의 활성을 갖는 배좌를 달성할 수 있다는 사실은 단백질 폴딩이 다중 폴딩 경로에 의해 일어난다는 설득력 있는 증거가 된다(Viguera, et al., J. Mol. Biol. 247:670-681, 1995). a-스펙트린의 SH3 도메인의 경우에는, b-헤어핀 턴에 대응하는 위치에서 새로운 말단을 선택하면 약간 낮은 안정성을 갖는 단백질이 생성되었으나 이 단백질은 그럼에도 불구하고 폴딩할 수 있었다.

본 명세서에서 인용된 연구에 사용되는 내부 절단점의 위치는 전적으로 단백질 표면에서만 발견되며, 명백히 말단 또는 중간부쪽으로 치우치지 않고 선형 서열 전체에 걸쳐 분포되어 있다(원래의 N-말단에서 절단점까지의 상대적 거리의 변화량은 총 서열길이의 약 10 내지 80이다). 이들 연구에서 원래의 N-말단과 C-말단을 연결하는 링커는 0 내지 9 잔기의 범위이었다. 한 경우(Yang & Schachman, Proc. Natl. Acad. Sci. U.S.A. 90:11980-11984, 1993)에는, 서열의 일부가 원래의 C-말단 세그먼트로부터 결실되었고, 끝이 절단된 C-말단에서 원래의 N-말단까지 연결이 행해졌다. Gly 및 Ser와 같은 가동성의 친수성 잔기가 링커에 자주 사용되고 있다. 비구에라(Viguera) 등(J. Mol. Biol. 247:670-681, 1995)은 원래의 N- 및 C-말단을 3- 또는 4-잔기 링커에 의해 연결하는 것을 비교하였다. 3-잔기 링커가 열역학적으로 덜 안정하였다. 프로타소바(Protasova) 등(Protein Eng. 7:1373-1377, 1994)은 E. coli 디히드로폴레이트 리덕타제의 원래의 N-말단을 연결하는데 3- 또는 5-잔기 링커를 사용하였다. 3-잔기 링커만이 양호한 수율로 단백질을 생성하였다.

발명의 개요

본 발명은 다음 식의 아미노산 서열을 포함하는 조혈 단백질에 관한 것이다.

R₁-L₁-R₂, R₂-L₁-R₁, R₁-R ₂, 또는 R₂-R₁

상기 식에서 R₁ 및 R₂는 독립적으로 다음의 (I) 내지 (VIII)로 이루어지는 군으로부터 선택된다.

(I) 다음 식의 변형된 EPO 아미노산 서열을 포함하는 사람 EPO 수용체 아고니스트 폴리펩티드:

여기서 선택적으로 N-말단으로부터의 1-6 아미노산 및 C-말단으로부터의 1-5 아미노산은 상기 EPO 수용체 아고니스트 폴리펩티드로부터 결실될 수 있고;

N-말단은 N-말단을 C-말단에 결합할 수 있고 다음 아미노산들 각각에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 또는 직접 C-말단에 결합된다.

23-24 47-48 109-110

24-25 48-49 110-111

25-26 49-50 111-112

26-27 50-51 112-113

27-28 51-52 113-114

28-29 52-53 114-115

29-30 53-54 115-116

30-31 54-55 116-117

31-32 55-56 117-118

32-33 56-57 118-119

33-34 57-58 119-120

34-35 77-78 120-121

35-36 78-79 121-122

36-37 79-80 122-123

37-38 80-81 123-124

38-39 81-82 124-125

39-40 82-83 125-126

40-41 84-85 126-127

41-42 85-86 127-128

42-43 86-87 128-129

43-44 87-88 129-130

44-45 88-89 130-131

45-46 108-109 131-132

46-47

(II) 다음 식의 변형된 간세포인자 아미노산 서열을 포함하는 사람 간세포인자 수용체 아고니스트 폴리펩티드:

여기서 선택적으로 1-23 아미노산은 상기 간세포인자 수용체 아고니스트 폴리펩티드의 C-말단으로부터 결실될 수 있고;

23-24 39-40 96-97

24-25 40-41 97-98

25-26 64-65 98-99

26-27 65-66 99-100

27-28 66-67 100-101

28-29 67-68 101-102

29-30 68-69 102-103

30-31 69-70 103-104

31-32 70-71 104-105

32-33 89-90 105-106

33-34 90-91 106-107

34-35 91-92 107-108

35-36 92-93 108-109

36-37 93-94 109-110

37-38 94-95 110-111

38-39 95-96

(III) 다음 식의 변형된 flt-3 리간드 아미노산 서열을 포함하는 사람 flt-3 수용체 아고니스트 폴리펩티드:

여기서 1-7 아미노산은 상기 flt-3 수용체 아고니스트 폴리펩티드의 C-말단으로부터 선택적으로 결실되고;

28-29 42-43 93-94

29-30 64-65 94-95

30-31 65-66 95-96

31-32 66-67 96-97

32-33 86-87 97-98

34-35 87-88 98-9936-37 88-89 99-100

삭제

37-38 89-90 100-101

38-39 90-91 101-102

39-40 91-92 102-103

40-41 92-93

41-42

(IV) 다음 식의 변형된 사람 G-CSF 아미노산 서열을 포함하는 폴리펩티드:

여기서 위치 1의 Xaa는 Thr, Ser, Arg, Tyr 또는 Gly;

위치 2의 Xaa는 Pro 또는 Leu;

위치 3의 Xaa는 Leu, Arg, Tyr 또는 Ser;

위치 13의 Xaa는 Phe, Ser, His, Thr 또는 Pro;

위치 16의 Xaa는 Lys, Pro, Ser, Thr 또는 His;

위치 17의 Xaa는 Cys, Ser, Gly, Ala, Ile, Tyr 또는 Arg;

위치 18의 Xaa는 Leu, Thr, Pro, His, Ile 또는 Cys;

위치 22의 Xaa는 Arg, Tyr, Ser, Thr 또는 Ala;

위치 24의 Xaa는 Ile, Pro, Tyr 또는 Leu;

위치 27의 Xaa는 Asp 또는 Gly;

위치 30의 Xaa는 Ala, Ile, Leu 또는 Gly;

위치 34의 Xaa는 Lys 또는 Ser;

위치 36의 Xaa는 Cys 또는 Ser;

위치 42의 Xaa는 Cys 또는 Ser;

위치 43의 Xaa는 His, Thr, Gly, Val, Lys, Trp, Ala, Arg, Cys 또는 Leu;

위치 44의 Xaa는 Pro, Gly, Arg, Asp, Val, Ala, His, Trp, Gln 또는 Thr;

위치 46의 Xaa는 Glu, Arg, Phe, Arg, Ile 또는 Ala;

위치 47의 Xaa는 Leu 또는 Thr;

위치 49의 Xaa는 Leu, Phe, Arg 또는 Ser;

위치 50의 Xaa는 Leu, Ile, His, Pro 또는 Tyr;

위치 54의 Xaa는 Leu 또는 His;

위치 64의 Xaa는 Cys 또는 Ser;

위치 67의 Xaa는 Gln, Lys, Leu 또는 Cys;

위치 70의 Xaa는 Gln, Pro, Leu, Arg 또는 Ser;

위치 74의 Xaa는 Cys 또는 Ser;

위치 104의 Xaa는 Asp, Gly 또는 Val;

위치 108의 Xaa는 Leu, Ala, Val, Arg, Trp, Gln 또는 Gly;

위치 115의 Xaa는 Thr, His, Leu 또는 Ala;

위치 120의 Xaa는 Gln, Gly, Arg, Lys 또는 His;

위치 123의 Xaa는 Glu, Arg, Phe 또는 Thr;

위치 144의 Xaa는 Phe, His, Arg, Pro, Leu, Gln 또는 Glu;

위치 146의 Xaa는 Arg 또는 Gln;

위치 147의 Xaa는 Arg 또는 Gln;

위치 156의 Xaa는 His, Gly 또는 Ser;

위치 159의 Xaa는 Ser, Arg, Thr, Tyr, Val 또는 Gly;

위치 162의 Xaa는 Glu, Leu, Gly 또는 Trp;

위치 163의 Xaa는 Val, Gly, Arg 또는 Ala;

위치 169의 Xaa는 Arg, Ser, Leu, Arg 또는 Cys;

위치 170의 Xaa는 His, Arg 또는 Ser이고;

여기서 N-말단으로부터의 1-11 아미노산 및 C-말단으로부터의 1-5 아미노산은 상기 변형된 사람 G-CSF 아미노산 서열로부터 선택적으로 결실될 수 있고;

38-39 62-63 123-124

39-40 63-64 124-125

40-41 64-65 125-126

41-42 65-66 126-127

42-43 66-67 128-129

43-44 67-68 128-129

45-46 68-69 129-130

48-49 69-70 130-131

49-50 70-71 131-132

52-53 71-72 132-133

53-54 91-92 133-134

54-55 92-93 134-135

55-56 93-94 135-136

56-57 94-95 136-137

57-58 95-96 137-138

58-59 96-97 138-139

59-60 97-98 139-140

60-61 98-99 140-141

61-62 99-100 141-142

또는 142-143

(V) 다음 식의 변형된 사람 IL-3 아미노산 서열을 포함하는 폴리펩티드:

여기서 위치 17의 Xaa는 Ser, Lys, Gly, Asp, Met, Gln 또는 Arg;

위치 18의 Xaa는 Asn, His, Leu, Ile, Phe, Arg 또는 Gln;

위치 19의 Xaa는 Met, Phe, Ile, Arg, Gly, Ala 또는 Cys;

위치 20의 Xaa는 Ile, Cys, Gln, Glu, Arg, Pro 또는 Ala;

위치 21의 Xaa는 Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser 또는 Val;

위치 22의 Xaa는 Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val 또는 Gly;

위치 23의 Xaa는 Ile, Val, Ala, Gly, Trp, Lys, Phe, Leu, Ser 또는 Arg;

위치 24의 Xaa는 Ile, Gly, Val, Arg, Ser, Phe 또는 Leu;

위치 25의 Xaa는 Thr, His, Gly, Gln, Arg, Pro 또는 Ala;

위치 26의 Xaa는 His, Thr, Phe, Gly, Arg, Ala 또는 Trp;

위치 27의 Xaa는 Leu, Gly, Arg, Thr, Ser 또는 Ala;

위치 28의 Xaa는 Lys, Arg, Leu, Gln, Gly, Pro, Val 또는 Trp;

위치 29의 Xaa는 Gln, Asn, Leu, Pro, Arg 또는 Val;

위치 30의 Xaa는 Pro, His, Thr, Gly, Asp, Gln, Ser, Leu 또는 Lys;

위치 31의 Xaa는 Pro, Asp, Gly, Ala, Arg, Leu 또는 Gln;

위치 32의 Xaa는 Leu, Val, Arg, Gln, Asn, Gly, Ala 또는 Glu;

위치 33의 Xaa는 Pro, Leu, Gln, Ala, Thr 또는 Glu;

위치 34의 Xaa는 Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile 또는 Met;

위치 35의 Xaa는 Leu, Ala, Gly, Asn, Pro, Gln 또는 Val;

위치 36의 Xaa는 Asp, Leu 또는 Val;

위치 37의 Xaa는 Phe, Ser, Pro, Trp 또는 Ile;

위치 38의 Xaa는 Asn 또는 Ala;

위치 40의 Xaa는 Leu, Trp 또는 Arg;

위치 41의 Xaa는 Asn, Cys, Arg, Leu, His, Met 또는 Pro;

위치 42의 Xaa는 Gly, Asp, Ser, Cys, Asn, Lys, Thr, Leu, Val, Glu, Phe, Tyr, Ile, Met 또는 Ala;

위치 43의 Xaa는 Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly 또는 Ser;

위치 44의 Xaa는 Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala 또는 Pro;

위치 45의 Xaa는 Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Trp, Asp, Asn, Arg, Ser, Ala, Ile, Glu 또는 His;

위치 46의 Xaa는 Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val 또는 Gly;

위치 47의 Xaa는 Ile, Gly, Val, Ser, Arg, Pro 또는 His;

위치 48의 Xaa는 Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val 또는 Asn;

위치 49의 Xaa는 Met, Arg, Ala, Gly, Pro, Asn, His 또는 Asp;

위치 50의 Xaa는 Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met 또는 Gln;

위치 51의 Xaa는 Asn, Arg, Met, Pro, Ser, Thr 또는 His;

위치 52의 Xaa는 Asn, His, Arg, Leu, Gly, Ser 또는 Thr;

위치 53의 Xaa는 Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser 또는 Met;

위치 54의 Xaa는 Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala 또는 Leu;

위치 55의 Xaa는 Arg, Thr, Val, Ser, Leu 또는 Gly;

위치 56의 Xaa는 Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val 또는 Lys;

위치 57의 Xaa는 Asn 또는 Gly;

위치 58의 Xaa는 Leu, Ser, Asp, Arg, Gln, Val 또는 Cys;

위치 59의 Xaa는 Glu Tyr, His, Leu, Pro 또는 Arg;

위치 60의 Xaa는 Ala, Ser, Pro, Tyr, Asn 또는 Thr;

위치 61의 Xaa는 Phe, Asn, Glu, Pro, Lys, Arg 또는 Ser;

위치 62의 Xaa는 Asn, His, Val, Arg, Pro, Thr, Asp 또는 Ile;

위치 63의 Xaa는 Arg, Tyr, Trp, Lys, Ser, His, Pro 또는 Val;

위치 64의 Xaa는 Ala, Asn, Pro, Ser 또는 Lys;

위치 65의 Xaa는 Val, Thr, Pro, His, Leu, Phe 또는 Ser;

위치 66의 Xaa는 Lys, Ile, Arg, Val, Asn, Glu 또는 Ser;

위치 67의 Xaa는 Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro 또는 His;

위치 68의 Xaa는 Leu, Val, Trp, Ser, Ile, Phe, Thr 또는 His;

위치 69의 Xaa는 Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly 또는 Leu;

위치 70의 Xaa는 Asn, Leu, Val, Trp, Pro 또는 Ala;

위치 71의 Xaa는 Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp 또는 Asn;

위치 72의 Xaa는 Ser, Glu, Met, Ala, His, Asn, Arg 또는 Asp;

위치 73의 Xaa는 Ala, Glu, Asp, Leu, Ser, Gly, Thr 또는 Arg;

위치 74의 Xaa는 Ile, Met, Thr, Pro, Arg, Gly 또는 Ala;

위치 75의 Xaa는 Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln 또는 Leu;

위치 76의 Xaa는 Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly 또는 Asp;

위치 77의 Xaa는 Ile, Ser, Arg, Thr 또는 Leu;

위치 78의 Xaa는 Leu, Ala, Ser, Glu, Phe, Gly 또는 Arg;

위치 79의 Xaa는 Lys, Thr, Asn, Met, Arg, Ile, Gly 또는 Asp;

위치 80의 Xaa는 Asn, Trp, Val, Gly, Thr, Leu, Glu 또는 Arg;

위치 81의 Xaa는 Leu, Gln, Gly, Ala, Trp, Arg, Val 또는 Lys;

위치 82의 Xaa는 Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met 또는 Val;

위치 83의 Xaa는 Pro, Ala, Thr, Trp, Arg 또는 Met;

위치 84의 Xaa는 Cys, Glu, Gly, Arg, Met 또는 Val;

위치 85의 Xaa는 Leu, Asn, Val 또는 Gln;

위치 86의 Xaa는 Pro, Cys, Arg, Ala 또는 Lys;

위치 87의 Xaa는 Leu, Ser, Trp 또는 Gly;

위치 88의 Xaa는 Ala, Lys, Arg, Val 또는 Trp;

위치 89의 Xaa는 Thr, Asp, Cys, Leu, Val, Glu, His, Asn 또는 Ser;

위치 90의 Xaa는 Ala, Pro, Ser, Thr, Gly, Asp, Ile 또는 Met;

위치 91의 Xaa는 Ala, Pro, Ser, Thr, Phe, Leu, Asp 또는 His;

위치 92의 Xaa는 Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile 또는 Leu;

위치 93의 Xaa는 Thr, Asp, Ser, Asn, Pro, Ala, Leu 또는 Arg;

위치 94의 Xaa는 Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala 또는 Pro;

위치 95의 Xaa는 His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile 또는 Tyr;

위치 96의 Xaa는 Pro, Lys, Tyr, Gly, Ile 또는 Thr;

위치 97의 Xaa는 Ile, Val, Lys, Ala 또는 Asn;

위치 98의 Xaa는 His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr 또는 Pro;

위치 99의 Xaa는 Ile, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe 또는 His;

위치 100의 Xaa는 Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln 또는 Pro;

위치 101의 Xaa는 Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu 또는 Gln;

위치 102의 Xaa는 Gly, Leu, Glu, Lys, Ser, Tyr 또는 Pro;

위치 103의 Xaa는 Asp 또는 Ser;

위치 104의 Xaa는 Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe 또는 Gly;

위치 105의 Xaa는 Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp 또는 His;

위치 106의 Xaa는 Glu, Ser, Ala, Lys, Thr, Ile, Gly 또는 Pro;

위치 108의 Xaa는 Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala 또는 Pro;

위치 109의 Xaa는 Arg, Thr, Pro, Glu, Tyr, Leu, Ser 또는 Gly;

위치 110의 Xaa는 Lys, Ala, Asn, Thr, Leu, Arg, Gln, His, Glu, Ser 또는 Trp;

위치 111의 Xaa는 Leu, Ile, Arg, Asp 또는 Met;

위치 112의 Xaa는 Thr, Val, Gln, Tyr, Glu, His, Ser 또는 Phe;

위치 113의 Xaa는 Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val 또는 Asn;

위치 114의 Xaa는 Tyr, Cys, His, Ser, Trp, Arg 또는 Leu;

위치 115의 Xaa는 Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp 또는 Met;

위치 116의 Xaa는 Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln 또는 Ile;

위치 117의 Xaa는 Thr, Ser, Asn, Ile, Trp, Lys 또는 Pro;

위치 118의 Xaa는 Leu, Ser, Pro, Ala, Glu, Cys, Asp 또는 Tyr;

위치 119의 Xaa는 Glu, Ser, Lys, Pro, Leu, Thr, Tyr 또는 Arg;

위치 120의 Xaa는 Asn, Ala, Pro, Leu, His, Val 또는 Gln;

위치 121의 Xaa는 Ala, Ser, Ile, Asn, Pro, Lys, Asp 또는 Gly;

위치 122의 Xaa는 Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr 또는 Cys;

위치 123의 Xaa는 Ala, Met, Glu, His, Ser, Pro, Tyr 또는 Leu이고;

여기서 1-14 아미노산은 상기 변형된 사람 IL-3 아미노산 서열의 N-말단으로부터 선택적으로 결실될 수 있고 그리고/또는 1-15 아미노산은 상기 변형된 사람 IL-3 아미노산 서열의 C-말단으로부터 선택적으로 결실될 수 있고; Xaa로 나타낸 아미노산 중 0 내지 44개는 천연 (1-133) 사람 인터루킨-3의 대응 아미노산과 상이하고;

26-27 49-50 83-84

27-28 50-51 84-85

28-29 51-52 85-86

29-30 52-53 86-87

30-31 53-54 87-88

31-32 54-55 88-89

32-33 64-65 89-90

33-34 65-66 90-91

34-35 66-67 91-92

35-36 67-68 92-93

36-37 68-69 97-98

37-38 69-70 98-99

38-39 70-71 99-100

39-40 71-72 100-101

40-41 72-73 101-102

41-42 82-83 102-103

또는 103-104

(VI) 다음 식의 변형된 사람 c-mpl 리간드 아미노산 서열을 포함하는 폴리펩티드:

여기서 위치 112의 Xaa는 결실되거나 또는 Leu, Ala, Val, Ile, Pro, Phe, Trp 또는 Met;

위치 113의 Xaa는 결실되거나 또는 Pro, Phe, Ala, Val, Leu, Ile, Trp 또는 Met;

위치 114의 Xaa는 결실되거나 또는 Pro, Phe, Ala, Val, Leu, Ile, Trp 또는 Met;

위치 115의 Xaa는 결실되거나 또는 Gln, Gly, Ser, Thr, Tyr 또는 Asn이고;

26-27 51-52 108-109

27-28 52-53 109-110

28-29 53-54 110-111

29-30 54-55 111-112

30-31 55-56 112-113

32-33 56-57 113-114

33-34 57-58 114-115

34-35 58-59 115-116

36-37 59-60 116-117

37-38 78-79 117-118

38-39 79-80 118-119

40-41 80-81 119-120

41-42 81-82 120-121

42-43 82-83 121-122

43-44 83-84 122-123

44-45 84-85 123-124

46-47 85-86 124-125

47-48 86-87 125-126

48-49 87-88 126-127

50-51 88-89 또는 127-128

(VII) 다음 식의 변형된 사람 IL-3 아미노산 서열을 포함하는 폴리펩티드:

여기서 위치 17의 Xaa는 Ser, Lys, Gly, Asp, Met, Gln 또는 Arg;

위치 18의 Xaa는 Asn, His, Leu, Ile, Phe, Arg 또는 Gln;

위치 19의 Xaa는 Met, Phe, Ile, Arg, Gly, Ala 또는 Cys;

위치 20의 Xaa는 Ile, Cys, Gln, Glu, Arg, Pro 또는 Ala;

위치 23의 Xaa는 Ile, Val, Ala, Gly, Trp, Lys, Phe, Leu, Ser 또는 Arg;

위치 24의 Xaa는 Ile, Gly, Val, Arg, Ser, Phe 또는 Leu;

위치 25의 Xaa는 Thr, His, Gly, Gln, Arg, Pro 또는 Ala;

위치 26의 Xaa는 His, Thr, Phe, Gly, Arg, Ala 또는 Trp;

위치 27의 Xaa는 Leu, Gly, Arg, Thr, Ser 또는 Ala;

위치 28의 Xaa는 Lys, Arg, Leu, Gln, Gly, Pro, Val 또는 Trp;

위치 29의 Xaa는 Gln, Asn, Leu, Pro, Arg 또는 Val;

위치 30의 Xaa는 Pro, His, Thr, Gly, Asp, Gln, Ser, Leu 또는 Lys;

위치 31의 Xaa는 Pro, Asp, Gly, Ala, Arg, Leu 또는 Gln;

위치 32의 Xaa는 Leu, Val, Arg, Gln, Asn, Gly, Ala 또는 Glu;

위치 33의 Xaa는 Pro, Leu, Gln, Ala, Thr 또는 Glu;

위치 35의 Xaa는 Leu, Ala, Gly, Asn, Pro, Gln 또는 Val;

위치 36의 Xaa는 Asp, Leu 또는 Val;

위치 37의 Xaa는 Phe, Ser, Pro, Trp 또는 Ile;

위치 38의 Xaa는 Asn 또는 Ala;

위치 40의 Xaa는 Leu, Trp 또는 Arg;

위치 41의 Xaa는 Asn, Cys, Arg, Leu, His, Met 또는 Pro;

위치 47의 Xaa는 Ile, Gly, Val, Ser, Arg, Pro 또는 His;

위치 49의 Xaa는 Met, Arg, Ala, Gly, Pro, Asn, His 또는 Asp;

위치 51의 Xaa는 Asn, Arg, Met, Pro, Ser, Thr 또는 His;

위치 52의 Xaa는 Asn, His, Arg, Leu, Gly, Ser 또는 Thr;

위치 53의 Xaa는 Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser 또는 Met;

위치 55의 Xaa는 Arg, Thr, Val, Ser, Leu 또는 Gly;

위치 57의 Xaa는 Asn 또는 Gly;

위치 58의 Xaa는 Leu, Ser, Asp, Arg, Gln, Val 또는 Cys;

위치 59의 Xaa는 Glu Tyr, His, Leu, Pro 또는 Arg;

위치 60의 Xaa는 Ala, Ser, Pro, Tyr, Asn 또는 Thr;

위치 61의 Xaa는 Phe, Asn, Glu, Pro, Lys, Arg 또는 Ser;

위치 62의 Xaa는 Asn, His, Val, Arg, Pro, Thr, Asp 또는 Ile;

위치 63의 Xaa는 Arg, Tyr, Trp, Lys, Ser, His, Pro 또는 Val;

위치 64의 Xaa는 Ala, Asn, Pro, Ser 또는 Lys;

위치 65의 Xaa는 Val, Thr, Pro, His, Leu, Phe 또는 Ser;

위치 66의 Xaa는 Lys, Ile, Arg, Val, Asn, Glu 또는 Ser;

위치 67의 Xaa는 Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro 또는 His;

위치 68의 Xaa는 Leu, Val, Trp, Ser, Ile, Phe, Thr 또는 His;

위치 69의 Xaa는 Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly 또는 Leu;

위치 70의 Xaa는 Asn, Leu, Val, Trp, Pro 또는 Ala;

위치 71의 Xaa는 Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp 또는 Asn;

위치 72의 Xaa는 Ser, Glu, Met, Ala, His, Asn, Arg 또는 Asp;

위치 73의 Xaa는 Ala, Glu, Asp, Leu, Ser, Gly, Thr 또는 Arg;

위치 74의 Xaa는 Ile, Met, Thr, Pro, Arg, Gly 또는 Ala;

위치 75의 Xaa는 Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln 또는 Leu;

위치 76의 Xaa는 Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly 또는 Asp;

위치 77의 Xaa는 Ile, Ser, Arg, Thr 또는 Leu;

위치 78의 Xaa는 Leu, Ala, Ser, Glu, Phe, Gly 또는 Arg;

위치 79의 Xaa는 Lys, Thr, Asn, Met, Arg, Ile, Gly 또는 Asp;

위치 80의 Xaa는 Asn, Trp, Val, Gly, Thr, Leu, Glu 또는 Arg;

위치 81의 Xaa는 Leu, Gln, Gly, Ala, Trp, Arg, Val 또는 Lys;

위치 83의 Xaa는 Pro, Ala, Thr, Trp, Arg 또는 Met;

위치 84의 Xaa는 Cys, Glu, Gly, Arg, Met 또는 Val;

위치 85의 Xaa는 Leu, Asn, Val 또는 Gln;

위치 86의 Xaa는 Pro, Cys, Arg, Ala 또는 Lys;

위치 87의 Xaa는 Leu, Ser, Trp 또는 Gly;

위치 88의 Xaa는 Ala, Lys, Arg, Val 또는 Trp;

위치 89의 Xaa는 Thr, Asp, Cys, Leu, Val, Glu, His, Asn 또는 Ser;

위치 90의 Xaa는 Ala, Pro, Ser, Thr, Gly, Asp, Ile 또는 Met;

위치 91의 Xaa는 Ala, Pro, Ser, Thr, Phe, Leu, Asp 또는 His;

위치 92의 Xaa는 Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile 또는 Leu;

위치 93의 Xaa는 Thr, Asp, Ser, Asn, Pro, Ala, Leu 또는 Arg;

위치 96의 Xaa는 Pro, Lys, Tyr, Gly, Ile 또는 Thr;

위치 97의 Xaa는 Ile, Val, Lys, Ala 또는 Asn;

위치 99의 Xaa는 le, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe 또는 His;

위치 100의 Xaa는 Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln 또는 Pro;

위치 102의 Xaa는 Gly, Leu, Glu, Lys, Ser, Tyr 또는 Pro;

위치 103의 Xaa는 Asp 또는 Ser;

위치 106의 Xaa는 Glu, Ser, Ala, Lys, Thr, Ile, Gly 또는 Pro;

위치 109의 Xaa는 Arg, Thr, Pro, Glu, Tyr, Leu, Ser 또는 Gly;

위치 111의 Xaa는 Leu, Ile, Arg, Asp 또는 Met;

위치 112의 Xaa는 Thr, Val, Gln, Tyr, Glu, His, Ser 또는 Phe;

위치 114의 Xaa는 Tyr, Cys, His, Ser, Trp, Arg 또는 Leu;

위치 115의 Xaa는 Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp 또는 Met;

위치 117의 Xaa는 Thr, Ser, Asn, Ile, Trp, Lys 또는 Pro;

위치 118의 Xaa는 Leu, Ser, Pro, Ala, Glu, Cys, Asp 또는 Tyr;

위치 119의 Xaa는 Glu, Ser, Lys, Pro, Leu, Thr, Tyr 또는 Arg;

위치 120의 Xaa는 Asn, Ala, Pro, Leu, His, Val 또는 Gln;

위치 121의 Xaa는 Ala, Ser, Ile, Asn, Pro, Lys, Asp 또는 Gly;

위치 123의 Xaa는 Ala, Met, Glu, His, Ser, Pro, Tyr 또는 Leu이고;

1-14 아미노산은 상기 변형된 사람 IL-3 아미노산 서열의 N-말단으로부터 선택적으로 결실될 수 있고 그리고/또는 1-15 아미노산은 상기 변형된 사람 IL-3 아미노산 서열의 C-말단으로부터 선택적으로 결실될 수 있고; Xaa로 나타낸 아미노산 중 1 내지 44개는 천연 (1-133) 사람 인터루킨-3의 대응 아미노산과 상이하다.

(VIII) 콜로니자극인자, 시토카인, 림포카인 및 인터루킨으로 이루어지는 군으로부터 선택된 인자.

또한 상기 식에서 L₁은 R₁을 R₂에 연결할 수 있는 링커이고;

단, 적어도 R₁또는 R₂는 식 (I), (II) 또는 (III)의 폴리펩티드로부터 선택되고;

상기 조혈 단백질은 선택적으로 (메티오닌^-1), (알라닌^-1) 또는 (메티오닌^-2, 알라닌^-1)이 바로 선행될 수 있다.

상기 폴리펩티드 (I)에서 새로운 C-말단 및 N-말단을 만들 수 있는 보다 바람직한 절단점은 23-24, 24-25, 25-26, 27-28, 28-29, 29-30, 30-31, 31-32, 32-33, 33-34, 34-35, 35-36, 36-37, 37-38, 38-39, 40-41, 41-42, 42-43, 52-53, 53-54, 54-55, 55-56, 77-78, 78-79, 79-80, 80-81, 81-82, 82-83, 83-84, 84-85, 85-86, 86-87, 109-110, 110-111, 111-112, 112-113, 113-114, 114-115, 115-116, 116-117, 117-118, 118-119, 119-120, 120-121, 121-122, 122-123, 123-124, 124-125, 125-126, 126-127, 127-128, 128-129, 129-130, 130-131 및 131-132이다.

상기 폴리펩티드 (I)에서 새로운 C-말단 및 N-말단을 만들 수 있는 가장 바람직한 절단점은 23-24, 24-25, 31-32, 32-33, 37-38, 38-39, 82-83, 83-84, 85-86, 86-87, 87-88, 125-126, 126-127 및 131-132이다.

본 발명의 EPO 수용체 아고니스트는 WO 94/24160에 개시된 것과 같은 아미노산 치환을 함유할 수 있거나 또는 Asn²⁴, Asn⁸³ 및 Asn¹²⁶의 한개 이상의 글리코실화 부위가 Asp 또는 Glu와 같은, 그러나 이것에 한정되지 않는 다른 아미노산으로 변화되고, 아미노산 결실 및/또는 삽입을 함유할 수 있다. 또한 본 발명의 EPO 수용체 아고니스트는 원래 단백질의 N-말단과 C-말단 중 어느 하나 또는 둘 다에서 아미노산 결실을 가질 수도 있고 그리고/또는 상기에 나타낸 서열 재배열된 단백질의 새로운 N- 및/또는 C-말단으로부터 결실될 수도 있게 하고자 한다.

상기 폴리펩티드 (II)에서 새로운 C-말단 및 N-말단을 만들 수 있는 보다 바람직한 절단점은 각각 23-24, 24-25, 25-26, 33-34, 34-35, 35-36, 36-37, 38-39, 39-40, 40-41, 64-65, 65-66, 66-67, 67-68, 68-69, 69-70, 70-71, 89-90, 90-91, 91-92, 92-93, 93-94, 94-95, 95-96, 96-97, 97-98, 98-99, 99-100, 100-101, 101-102, 102-103, 103-104, 104-105 및 105-106이다.

상기 폴리펩티드 (II)에서 새로운 C-말단 및 N-말단을 만들 수 있는 가장 바람직한 절단점은 각각 64-65, 65-66, 92-93 및 93-94이다.

상기 폴리펩티드 (III)에서 새로운 C-말단 및 N-말단을 만들 수 있는 보다 바람직한 절단점은 36-37, 37-38, 39-40, 41-42, 42-43, 64-65, 65-66, 66-67, 86-87, 87-88, 88-89, 89-90, 90-91, 91-92, 92-93, 93-94, 94-95, 95-96, 96-97, 97-98, 98-99, 99-100 및 100-101이다.

상기 폴리펩티드 (III)에서 새로운 C-말단 및 N-말단을 만들 수 있는 가장 바람직한 절단점은 39-40, 65-66, 89-90, 99-100 및 100-101이다.

상기 폴리펩티드 (IV)에서 새로운 C-말단 및 N-말단을 만들 수 있는 보다 바람직한 절단점은 38-39, 39-40, 40-41, 41-42, 48-49, 53-54, 54-55, 55-56, 56-57, 57-58, 58-59, 59-60, 60-61, 61-62, 62-63, 64-65, 65-66, 66-67, 67-68, 68-69, 69-70, 96-97, 125-126, 126-127, 127-128, 128-129, 129-130, 130-131, 131-132, 132-133, 133-134, 134-135, 135-136, 136-137, 137-138, 138-139, 139-140, 140-141 및 141-142이다.

상기 폴리펩티드 (IV)에서 새로운 C-말단 및 N-말단을 만들 수 있는 가장 바람직한 절단점은 38-39, 48-49, 96-97, 125-126, 132-133 및 141-142이다.

상기 폴리펩티드 (V)에서 새로운 C-말단 및 N-말단을 만들 수 있는 보다 바람직한 절단점은 28-29, 29-30, 30-31, 31-32, 32-33, 33-34, 34-35, 35-36, 36-37, 37-38, 38-39, 39-40, 66-67, 67-68, 68-69, 69-70, 70-71, 84-85, 85-86, 86-87, 87-88, 88-89, 89-90, 90-91, 98-99, 99-100, 100-101 및 101-102이다.

상기 폴리펩티드 (V)에서 새로운 C-말단 및 N-말단을 만들 수 있는 가장 바람직한 절단점은 34-35, 69-70 및 90-91이다.

상기 폴리펩티드 (VI)에서 새로운 C-말단 및 N-말단을 만들 수 있는 보다 바람직한 절단점은 80-81, 81-82, 82-83, 83-84, 84-85, 85-86, 86-87, 108-109, 109-110, 110-111, 111-112, 112-113, 113-114, 114-115, 115-116, 116-117, 117-118, 118-119, 119-120, 120-121, 121-122, 122-123, 123-124, 124-125, 125-126 및 126-127이다.

상기 폴리펩티드 (VI)에서 새로운 C-말단 및 N-말단을 만들 수 있는 가장 바람직한 절단점은 81-82, 108-109, 115-116, 119-120, 122-123 및 125-126이다.

본 발명의 다기능성 수용체 아고니스트는 또한 다음 식으로 표시될 수 있다.

(T¹)_a-(L¹)_b-X¹-(L)_c-X²-(L ²)_d-(T²)_e

또는

X¹-(L)_c-X²-(L)-Y¹-(L)_c-Y²

상기 식에서,

X¹은 1 내지 J로 순차적으로 번호가 매겨진 아미노산 잔기를 갖고 잔기 1에 아미노 말단을 갖는 원래 단백질의 잔기 n+1 내지 J의 서열에 대응하는 아미노산 서열을 포함하는 펩티드이고;

L은 선택적 링커이고;

X²는 원래 단백질의 잔기 1 내지 n의 아미노산 서열을 포함하는 펩티드이고;

Y¹은 1 내지 K로 순차적으로 번호가 매겨진 아미노산 잔기를 갖고 잔기 1에 아미노 말단을 갖는 원래 단백질의 잔기 n=1 내지 K의 서열에 대응하는 아미노산 서열을 포함하는 펩티드이고;

Y²는 원래 단백질의 잔기 1 내지 n의 아미노산 서열을 포함하는 펩티드이고;

L¹ 및 L²는 선택적 펩티드 스페이서이고;

n은 1 내지 J-1 범위의 정수이고;

b, c 및 d는 각각 독립적으로 0 또는 1이고;

a 및 e는 0 또는 1이고, 단 a 및 e 양자가 둘다 0일 수는 없고;

T¹ 및 T²는 단백질이다.

본 발명의 다기능 키메라 조혈 수용체 아고니스트는 키메라 분자의 각 단백질 성분내에 아미노산 치환, 결실 및/또는 삽입을 함유할 수 있다. 또한 본 발명의 다기능 키메라 조혈 수용체 아고니스트는 원래 단백질의 N-말단과 C-말단 중 어느 하나 또는 둘 다에서 아미노산 결실을 가질 수도 있고 그리고/또는 상기에 나타낸 식에서 서열 재배열된 단백질의 새로운 N- 및/또는 C-말단으로부터 결실될 수도 있게 하고자 한다.

본 발명의 바람직한 구체예에서는, N-말단을 C-말단에 결합하는 상기 식의 링커 (L), (L¹) 또는 (L²)가 다음으로 이루어지는 군으로부터 선택된 폴리펩티드이다.

Ser;

Asn;

Gly;

Thr;

GlySer;

AlaAla;

GlySerGly;

GlyGlyGly;

GlyAsnGly;

GlyAlaGly;

GlyThrGly;

AlaSerAla;

AlaAlaAla;

GlyGlyGlySer SEQ ID NO:778;

GlyGlyGlySerGlyGlyGlySer SEQ ID NO:779;

GlyGlyGlySerGlyGlyGlySerGlyGlyGlySer SEQ ID NO:780;

SerGlyGlySerGlyGlySer SEQ ID NO:781;

GluPheGlyAsnMet SEQ ID NO:782;

GluPheGlyGlyAsnMet SEQ ID NO:783;

GluPheGlyGlyAsnGlyGlyAsnMet SEQ ID NO:784;

GlyGlySerAspMetAlaGly SEQ ID NO:785;

SerGlyGlyAsnGly SEQ ID NO:786;

SerGlyGlyAsnGlySerGlyGlyAsnGly SEQ ID NO:787;

SerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGly SEQ ID NO:788;

SerGlyGlySerGlySerGlyGlySerGly SEQ ID NO:789;

SerGlyGlySerGlySerGlyGlySerGlySerGlyGlySerGly SEQ ID NO:790;

GlyGlyGlySerGlyGly SEQ ID NO:791;

GlyGlyGlySerGlyGlyGly SEQ ID NO:792;

GlyGlyGlySerGlyGlyGlySerGlyGly SEQ ID NO:793;

GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly SEQ ID NO:794;

GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGly SEQ ID NO:795;

GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly SEQ ID NO:796;

ProProProTrpSerProArgProLeuGlyAlaThrAlaProThrAlaGlyGlnProProLeu SEQ ID NO:797;

ProProProTrpSerProArgProLeuGlyAlaThrAlaProThr SEQ ID NO:798; 및

ValGluThrValPheHisArgValSerGlnAspGlyLeuLeuThrSer SEQ ID NO:799.

또한, 본 발명은 다기능 키메라 조혈 수용체 아고니스트를 암호화하는 뉴클레오티드 서열을 포함하는 재조합 발현벡터, 관련 미생물 발현시스템, 및 다기능 키메라 조혈 수용체 아고니스트의 제조방법에 관한 것이다. 본 발명은 또한 다기능 키메라 조혈 수용체 아고니스트를 함유하는 약학적 조성물, 및 다기능 키메라 조혈 수용체 아고니스트의 사용방법에 관한 것이다.

본 발명의 다기능 키메라 조혈 수용체 아고니스트의 생체내 사용 외에, 시험관내 사용은 환자로의 주입 전에 골수 및 혈액 세포 활성화 및 성장을 자극하는 능력을 포함하는 것으로 예상된다. 또 다른 의도된 용도는 생체내 및 생체외 둘 다에서 수상 세포를 생성하는 것이다.

융합 단백질의 감소된 친화성은 각 부분이 키메라 분자에 혼입될 때 그것의 천연 배좌를 달성할 능력이 없는 것에, 또는 융합 단백질의 각 부분의 활성 부위 사이의 입체 장해에 적어도 부분적으로 기인하는 것으로 여겨진다. 본 발명은 이러한 한계를 극복하여 키메라 분자의 각 성분에 필적하거나 또는 그 보다 더 큰 결합친화성을 갖는 신규의 다기능 키메라 조혈 수용체 아고니스트를 제공한다.

도 1은 단백질의 서열 재배열을 개략적으로 예시한 것이다. 천연 단백질의 N-말단(N)과 C-말단(C)을 링커를 통해 결합하거나 또는 직접 결합한다. 이 단백질을 새로운 N-말단(새로운 N)과 새로운 C-말단(새로운 C)을 만드는 절단점에서 개방하여 새로운 선형 아미노산 서열을 갖는 단백질을 얻는다. 원래의 N-말단과 C-말단을 결합하는 단계 및 단백질을 절단점에서 개방하는 단계를 거치지 않고 처음부터 재배열 분자를 선형 분자로서 합성할 수도 있다.

도 2는 새로운 단백질을 생성하는 방법 I의 개략도인데, 이 방법에서는 천연 단백질의 원래의 N-말단과 C-말단을 링커에 의해 결합하고 단백질의 상이한 N-말단과 C-말단을 만든다. 도시된 예에서 서열 재배열은 원래 단백질의 아미노산 97에 만들어진 새로운 N-말단, 링커 영역을 통해 아미노산 11(아미노산 1-10은 결실됨)에 결합된 원래의 C-말단(아미노산 174) 및 원래 서열의 아미노산 96에 만들어진 새로운 C-말단을 갖는 단백질을 암호화하는 새로운 유전자를 초래한다.

도 3은 새로운 단백질을 생성하는 방법 II의 개략도인데, 이 방법에서는 천연 단백질의 원래의 N-말단과 C-말단을 링커 없이 결합하고 단백질의 상이한 N-말단과 C-말단을 만든다. 도시된 예에서 서열 재배열은 원래 단백질의 아미노산 97에 만들어진 새로운 N-말단, 원래의 N-말단에 결합된 원래의 C-말단(아미노산 174) 및 원래 서열의 아미노산 96에 만들어진 새로운 C-말단을 갖는 단백질을 암호화하는 새로운 유전자를 초래한다.

도 4는 새로운 단백질을 생성하는 방법 III의 개략도인데, 이 방법에서는 천연 단백질의 원래의 N-말단과 C-말단을 링커에 의해 결합하고 단백질의 상이한 N-말단과 C-말단을 만든다. 도시된 예에서 서열 재배열은 원래 단백질의 아미노산 97에 만들어진 새로운 N-말단, 링커 영역을 통해 아미노산 1에 결합된 원래의 C-말단(아미노산 174) 및 원래 서열의 아미노산 96에 만들어진 새로운 C-말단을 갖는 단백질을 암호화하는 새로운 유전자를 초래한다.

도 5는 MUTZ-2 세포증식분석법으로 재조합 천연 flt3(Genzyme)과 비교한, flt3 수용체 아고니스트 pMON32332, pMON32333, pMON32334 및 pMON32335로 이루어지는 다기능성 수용체 아고니스트의 활성을 나타낸다. MT=mock 트랜스펙션

도 6은 린(Lin) 등(PNAS 82:7580-7584, 1985)의 서열에 기초한 사람 성숙 EPO를 암호화하는 DNA 서열을 나타낸다.

도 7a 및 7b는 마틴(Martin) 등(Cell 63:203-211, 1990)의 서열에 기초한 천연 간세포 인자를 암호화하는 DNA 서열을 나타낸다.

도 8은 랭글리(Langley) 등(Archives of Bichemistry and Biophysica 311:55-61, 1994)의 서열에 기초한 가용성 간세포 인자를 암호화하는 DNA 서열을 나타낸다.

도 9a 및 9b는 라이먼(Lyman) 등(Oncogene 11:1165-1172, 1995)으로부터의 flt3 리간드의 209 아미노산 성숙 형태를 암호화하는 DNA 서열을 나타낸다.

도 10은 라이먼(Lyman) 등(Oncogene 11:1165-1172, 1995)으로부터의 flt3 리간드의 134 아미노산 가용성 형태를 암호화하는 DNA 서열을 나타낸다.

본 발명은 공유결합된 폴리펩티드로부터 형성된 다기능 키메라 조혈 수용체 아고니스트를 포함하며, 각각의 폴리펩티드는 서로 다른 특이적 세포 수용체를 통해 작용하여 상보적 생물학적 활성을 개시할 수 있다. 조혈은 간세포가 모든 주요 계통에서 큰 집단의 성숙세포로 연속 생성되는 복잡한 일련의 세포사건을 필요로 한다. 현재 적어도 20개의 공지된 조혈증식활성을 갖는 조절인자가 있다. 대부분의 이들 증식 조절인자는 단지 시험관내에서 여러 유형의 콜로니 형성을 자극할 수 있을 뿐이며, 각 조절인자에 의해 자극되는 콜로니 형성의 정확한 패턴은 매우 특이하다. 콜로니 개수에 의해, 더 중요하게는 발생중인 콜로니를 만드는 세포의 계통 및 성숙 패턴에 의해 평가될 때, 두 개의 조절인자는 정확하게 동일한 패턴의 콜로니 형성을 자극하지 않는다. 증식반응은 단순화된 시험관내 배양시스템에서 가장 용이하게 분석될 수 있다. 3가지 꽤다른 매개인자가 구별될 수 있다. 콜로니 크기의 변화, 콜로니 개수의 변화 및 세포 계통이 그것이다. 두 개 이상의 인자가 전구세포에 작용하여 다수의 자손형성을 유도함으로써 콜로니 크기를 증가시킬 수 있다. 두 개 이상의 인자는 한가지 인자에 배타적으로 반응하는 독특한 전구세포의 서브세트가 존재하기 때문에 또는 약간의 전구체가 반응할 수 있기 전에 두 개 이상의 인자에 의한 자극을 필요로 하기 때문에 증가된 개수의 전구세포가 증식되도록 할 수 있다. 두 개 이상의 인자의 사용에 의한 세포에 대한 부가적 수용체의 활성화는 초기의 서로 다른 신호경로에서 핵에 도달하는 공통의 최종경로로의 합체로 인해 유사분열신호를 향상시키기 쉽다(Metcalf, Nature 339:27, 1989). 다른 메카니즘은 상승작용을 설명해 줄 수 있다. 예를 들어 만약 한가지 신호경로가 제 2 인자에 의해 야기되는 부가적 신호경로의 중간체 활성화에 의해 제한되면 이것은 초부가적 반응을 초래할 수 있다. 약간의 경우에는, 한 수용체 유형의 활성화가 다른 수용체의 향상된 발현을 유도할 수 있다(Metcalf, Blood 82:3515-3523, 1993). 두 개 이상의 인자는 단일인자와 다른 패턴의 세포 계통을 초래할 수 있다. 다기능 키메라 조혈 수용체 아고니스트의 사용은 어떤 단일 인자에 의해서도 불가능한 증식반응으로 인한 잠재적 임상적 이점을 가질 수 있다.

조혈성장인자 및 다른 성장인자의 수용체는 두가지 별개의 관련 단백질군으로 구분될 수 있다. 즉, (1) 표피성장인자, M-CSF(Sherr, Blood 75:1, 1990) 및 SCF(Yarden et al., EMBO J. 6:3341, 1987)에 대한 것들을 포함하는 티로신 키나제 수용체; 및 (2) 티로신 키나제 도메인을 함유하지 않으나 그들의 세포외 도메인에서 분명한 상동성을 나타내는 조혈 수용체(Bazan, PNAS USA 87:6934-6938, 1990). 상기 후자의 군에는 에리트로포이에틴(EPO)(D'Andrea et al., Cell 57:277, 1989), GM-CSF(Gearing et al., EMBO J. 8:3667, 1989), IL-3(Kitamura et al., Cell 66:1165, 1991), G-CSF(Fukunaga et al., J. Bio. Chem. 265:14008-15, 1990), IL-4(Harada et al., PNAS USA 87:857, 1990), IL-5(Takaki et al., EMBO J. 9:4367, 1990), IL-6(Yamasaki et al., Science 241:825, 1988), IL-7(Goodwin et al., Cell 60:941-51, 1990), LIF(Gearing et al., EMBO J. 10:2839, 1991) 및 IL-2(Cosman et al., Mol-Immunol. 23: 935-94, 1986)가 포함된다. 후자 수용체군의 대부분은 이종이합체로서 고친화성 형태로 존재한다. 리간드 결합후에, 특이적 a-사슬은 적어도 한 개의 다른 수용체 사슬(b-사슬, g-사슬)과 회합된다. 이들 인자의 다수는 공통의 수용체 서브유니트를 공유한다. GM-CSF, IL-3 및 IL-5에 대한 a-사슬은 동일한 b-사슬을 공유하며(Kitamura et al., Cell 66:1165, 1991; Takaki et al., EMBO J. 10:2833-8, 1991), IL-6, LIF 및 IL-11에 대한 수용체 복합체는 공통의 b-사슬(gp130)을 공유한다(Taga et al., Cell 58:573-81, 1989; Gearing et al., Science 255:1434-7, 1992). IL-2, IL-4, IL-7, IL-9 및 IL-15의 수용체 복합체는 공통의 g-사슬을 공유한다(Kondo et al., Science 262:1874, 1993; Russell et al., Science 266: 1042-1045, 1993; Noguchi et al., Science 262:1877, 1993; Giri et al., EMBO J. 13:2822-2830, 1994).

다작용 조혈 인자의 사용은 또한 인자 생산 세포 및 그것의 유도시스템에 놓여진 수요를 감소시킴으로써 잠재적 이점을 가질 수 있다. 세포가 인자를 생산하는 능력에 제한이 있으면, 각각의 인자의 필요농도를 저하시키고 그것들을 조합하여 사용함으로써 유용하게 인자 생산 세포에 대한 수요를 감소시킬 수 있다. 다작용 조혈 인자의 사용은 필요로 하는 인자의 양을 저하시켜, 아마도 역부작용과 같은 것을 감소시킬 수 있을 것이다.

본 발명의 신규 화합물은

R₁-L₁-R₂, R₂-L₁-R₁, R₁-R ₂, 및 R₂-R₁

으로 이루어지는 군으로부터 선택된 식으로 표시된다.

상기 식에서 R₁ 및 R₂는 상기 정의와 같다. R₂는 바람직하게는 R₁과 다르나 상보적인 활성을 갖는 콜로니자극인자이다. 상보적 활성이란 또 다른 세포 조정인자에 대한 반응을 향상 또는 변화시키는 활성을 의미한다. R₁ 폴리펩티드는 직접 또는 링커 세그먼트를 통해 R₂ 폴리펩티드에 결합된다. "직접"이란 용어는 폴리펩티드가 펩티드 링커 없이 결합된 다기능 키메라 조혈 수용체 아고니스트를 의미한다. 따라서 L₁은 R₁ 및 R₂ 둘 다가 프레임내에 결합된 화학결합 또는 폴리펩티드 세그먼트를 나타내며, 가장 일반적으로 L₁은 R₁의 카르복시말단을 L₁의 아미노말단에, L₁의 카르복시말단을 R₂의 아미노말단에 연결시키는 아미드결합에 의해 R₁ 및 R₂가 결합된 선형펩티드이다. "프레임내에에 결합된"이란 R₁과 R₂를 암호화하는 DNA의 해독 프레임 사이에 번역종결 또는 중단이 없다는 것을 의미한다.

(I), (II) 또는 (III)에 결합될 수 있는 다른 성장인자, 즉 콜로니자극인자(CSF), 시토카인, 림포카인, 인터루킨, 조혈성장인자의 비배타적 리스트는 GM-CSF, G-CSF, c-mpl 리간드(TPO 또는 MGDF로도 알려짐), M-CSF, 에리트로포이에틴(EPO), IL-1, IL-4, IL-2, IL-3, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, LIF, flt3/flk2 리간드, 사람성장호르몬, B-세포성장인자, B-세포분화인자, 호산구분화인자, 및 스틸인자 또는 c-kit 리간드로도 알려진 간세포인자(SCF)를 포함한다. 더욱이, 본 발명은 변형된 R₁또는 R₂ 분자 또는 이들 R₁또는 R₂ 분자를 암호화하는 돌연변이되거나 또는 변형된 DNA 서열의 사용을 포함한다. 또한 본 발명은 R₁또는 R₂가 hIL-3 변이체, c-mpl 리간드 변이체, 또는 G-CSF 변이체인 다기능 키메라 조혈 수용체 아고니스트를 포함한다. "hIL-3 변이체"는 WO 94/12638, WO 94/12639 및 WO 95/00646에 개시된 바와 같은 아미노산 치환 및/또는 결실된 hIL-3 부분을 갖는 hIL-3 분자 뿐만 아니라 당업계에 공지된 다른 변이체로서 정의된다. "c-mpl 리간드 변이체"는 미국출원 일련번호 08/383,035에 개시된 아미노산 치환 및/또는 결실된 c-mpl 리간드 부분을 갖는 c-mpl 리간드 분자 뿐만 아니라 당업계에 공지된 다른 변이체로서 정의된다. "G-CSF 변이체"는 본 명세서에 개시된 바와 같은 아미노산 치환 및/또는 결실된 G-CSF 부분을 갖는 G-CSF 분자 뿐만 아니라 당업계에 공지된 다른 변이체로서 정의된다. 상기 리스트 외에, WO 94/12639 및 WO 94/12638에 교시된 IL-3 변이체, WO 97/12977에 개시된 G-CSF 수용체 아고니스트, WO 97/12978에 개시된 c-mpl 수용체 아고니스트 및 WO 97/12979에 개시된 IL-3 수용체 아고니스트도 본 발명의 R₁ 또는 R₂가 될 수 있다. 본 명세서에서 사용될 때 "IL-3 변이체"란 WO 94/12639 및 WO 94/12638에 교시된 IL-3 변이체를 말한다. 본 명세서에서 사용될 때 "융합 단백질"이란 WO 95/21197 및 WO 95/21254에 교시된 융합 단백질을 말한다. 본 명세서에서 사용될 때 "G-CSF 수용체 아고니스트"란 WO 97/12978에 개시된 G-CSF 수용체 아고니스트를 말한다. 본 명세서에서 사용될 때 "c-mpl 수용체 아고니스트"란 WO 97/12978에 개시된 c-mpl 수용체 아고니스트를 말한다. 본 명세서에서 사용될 때 "IL-3 수용체 아고니스트"란 WO 97/12979에 개시된 IL-3 수용체 아고니스트를 말한다. 본 명세서에서 사용될 때 "다기능성 수용체 아고니스트"란 WO 97/12985에 교시된 다기능성 수용체 아고니스트를 말한다.

연결 기(L₁)는 일반적으로 길이가 1 내지 500 아미노산인 폴리펩티드이다. 두 개의 분자를 연결하는 링커는 바람직하게는 (1) 두 개의 분자가 서로 독립적으로 폴딩되고 작용하도록 하고, (2) 두 개의 단백질의 기능적 도메인을 방해할 수 있는 순차적 2차구조를 발생시키는 경향을 가지지 않고, (3) 기능적 단백질 도메인과 상호작용할 수 있는 최소의 소수성 특성을 갖고, (4) R₁ 및 R₂가 단일세포상의 그들의 대응 수용체와 동시에 상호작용할 수 있도록 R₁ 및 R₂의 입체분리를 제공하도록 설계된다. 전형적으로 가동성(flexible) 단백질 영역내의 표면 아미노산은 Gly, Asn 및 Ser을 포함한다. 실제로 Gly, Asn 및 Ser을 함유하는 아미노산 서열의 어떤 순열도 링커 서열에 대한 상기 기준을 만족한다고 기대될 것이다. Thr 및 Ala와 같은 다른 중성 아미노산도 또한 링커서열에 사용될 수 있다. 부가적 아미노산이 또한 링커서열내로의 독특한 제한부위의 첨가로 인해 링커에 포함되어 다기능 키메라 조혈 수용체 아고니스트의 구성을 용이하게 할 수 있다.

본 발명의 바람직한 L₁ 링커는 식 (Gly³Ser)ⁿ(SEQ ID NO:861), (Gly⁴Ser)ⁿ(SEQ ID NO:862), (Gly⁵Ser)ⁿ(SEQ ID NO:863), (GlyⁿSer)ⁿ(SEQ ID NO:864) 또는 (AlaGlySer)ⁿ(SEQ ID NO:865)의 군으로부터 선택된 서열을 포함한다.

고가동성 링커의 한가지 예는 사상 박테리오파지, 예컨대 박테리오파지 M13 또는 fd의 pIII 단백질내에 존재하는, 글리세린 및 세린이 풍부한 스페이서 영역이다(Schaller et al., PNAS USA 72: 737-741, 1975). 이 영역은 pIII 표면 단백질의 두 개의 도메인 사이에 긴 가동성 스페이서 영역을 제공한다. 스페이서 영역은 다음 아미노산 서열로 이루어진다.

GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGluGlyGlyGlySerGlu

GlyGlyGlySerGluGlyGlyGlySerGluGlyGlyGlySerGlyGlyGlySer

(SEQ ID NO:800).

또한, 본 발명은 엔도펩티다제 인식서열이 포함된 링커를 포함한다. 그러한 절단부위는 다기능 키메라 조혈 수용체 아고니스트의 각 성분이 시험관내에서 적당히 폴딩되고 활성적인지를 결정하기 위해 그것들을 분리하는데 가치있을 수 있다. 여러 엔도펩티다제의 예로는 플라스민, 엔테로키나제, 칼리크레인, 유로키나제, 조직 플라스미노겐 활성인자, 클로스트리파인, 키모신, 콜라게나제, Russell의 독사독액 프로테아제, 포스트프롤린 절단효소, V8 프로테아제, 트롬빈 및 인자 Xa를 들 수 있으나 이에 한정되지는 않는다.

중사슬 면역글로불린 IgG, IgA, IgM, IgD 또는 IgE의 힌지영역으로부터의 펩티드 링커 세그먼트는 부착된 폴리펩티드 사이의 각도 관계를 제공한다. 시스테인이 세린으로 치환된 힌지 영역이 특히 유용하다. 본 발명의 바람직한 링커는 시스테인이 세린으로 바뀐 쥐 IgG 감마 2b 힌지 영역으로부터 유래된 서열을 포함한다. 이들 링커는 또한 엔도펩티다제 절단부위를 포함할 수 있다. 그러한 링커의 예로는 다음 서열을 들 수 있다:

IleSerGluProSerGlyProIleSerThrIleAsnProSerProProSerLys

GluSerHisLysSerPro (SEQ ID NO:801) 및

IleGluGlyArgIleSerGluProSerGlyProIleSerThrIleAsnProSer

ProProSerLysGluSerHisLysSerPro (SEQ ID NO:802).

그러나, 본 발명은 사용되는 링커서열의 형태, 크기 또는 개수에 의해 한정되지 않으며, 링커의 단 하나의 요구조건은 그것이 기능적으로 다기능 키메라 조혈 수용체 아고니스트의 각 분자의 폴딩 및 기능을 방해하지 않는 것이다.

링커 L ₂ 의 결정

R₁ 및/또는 R₂에 사용되는 링커 L₂의 아미노산 서열의 길이는 경험에 의해 또는 구조 정보로부터의 지침에 따라 선택되거나 또는 이 두가지 접근법의 조합을 사용하여 선택될 수 있다.

구조 정보를 얻을 수 없을 때는, 길이를 0 내지 50Å의 범위가 되도록 변화시키고 표면 노출(친수성, Hopp & Woods, Mol. Immunol. 20: 483-489, 1983; Kyte & Doolittle, J. Mol. Biol. 157:105-132; 용매 노출된 표면부위, Lee & Richards, J. Mol. Biol. 55:379-400, 1971) 및 R¹ 또는 R²의 배좌를 이상하게 하지 않고 필요한 배좌를 채택하는 능력(배좌 가동성; Karplus & Schulz, Naturwissenschaften 72:212-213, 1985)과 양립되도록 서열을 선택하는 디자인을 사용하여 시험을 위해 소량의 일련의 링커를 제조할 수 있다. 잔기당 번역 평균이 2.0 내지 3.8Å인 것으로 가정할 때, 이것은 시험할 길이가 0 내지 30 잔기임을 의미하고, 0 내지 15 잔기가 바람직한 범위이다. 이러한 경험적 시리즈의 예는 n번(여기서 n은 1, 2, 3 또는 4임) 반복된 "Gly-Gly-Gly-Ser"와 같은 카세트 서열을 사용하여 링커를 구성하는 것이다. 당업자는 길이 또는 조성이 다양하고 링커로서 작용할 수 있는 그러한 서열이 많이 있고 주요 고려사항은 이러한 서열이 지나치게 길거나 짧지 않아야 한다는 것임을 알 수 있을 것이다(Sandhu, Critical Rev. Biotech. 12: 437-462, 1992 참조). 이들이 너무 길면 엔트로피 효과가 3차원 폴딩을 불안정화시킬 것이고 또한 폴딩을 속도론적으로 비실용적이게 할 것이며, 이들이 너무 짧으면 비틀림 및 입체 변형 때문에 엔트로피 효과가 분자를 불활성화시킬 것이다.

단백질 구조 정보의 분석에 숙련된 자는 c-알파 탄소들간의 거리로서 정의되는 사슬 말단들간의 거리를 사용하여, 사용될 서열의 길이를 정의하거나, 또는 적어도 링커의 경험적 선택시에 시험되어야 하는 가능성의 수를 제한할 수 있음을 알 수 있을 것이다. 그들은 또한 x-선 회절 또는 핵자기공명 분광 데이터로부터 얻어지는 구조 모델에서는 폴리펩티드 사슬의 말단 위치가 명백하지 않은 경우가 종종 있고, 따라서 이것이 사실일 때는 필요한 링커의 길이를 적당히 추정하기 위해 이러한 상황을 고려할 필요가 있음을 알 수 있을 것이다. 그 위치가 명확한 잔기들로부터 사슬 말단과 서열이 밀접한 두개의 잔기를 선택하고, 이들 잔기의 c-알파 탄소간의 거리를 사용하여 이들 잔기 사이의 링커에 대한 대략적 길이를 산출한다. 산출된 길이를 지침으로 하여, 이어서 일정 범위의 잔기수(잔기당 2 내지 3.8Å을 사용하여 산출)를 갖는 링커를 선택한다. 이들 링커는 원래의 서열로 구성될 수도 있고 필요에 따라 단축되거나 연장될 수도 있으며, 연장될 때는 추가 잔기를 상기한 바와 같이 가동성 및 친수성이 되도록 선택할 수 있다. 또는 선택적으로 원래의 서열을 일련의 링커를 사용하여 치환시킬 수도 있고, 그 일례는 상기에 언급된 "Gly-Gly-Gly-Ser" 카세트 접근법이다. 또는 선택적으로 적당한 총 길이를 갖는 새로운 서열과 원래 서열의 조합을 사용할 수도 있다.

R ₁ 및 R ₂ 의 아미노 및 카르복실 말단의 결정

생물학적 활성 상태로 폴딩할 수 있는 R₁ 및 R₂의 서열은 상기한 바와 같은 링커 서열 L₂를 사용하면서 원래의 폴리펩티드 사슬내로부터 개시(아미노 말단) 및 종결(카르복시 말단) 위치를 적당히 선택하여 제조될 수 있다. 아미노 및 카르복실 말단은 이하에 기재된 지침을 사용하여, 절단점 영역이라 불리는 통상의 서열 스트레치내로부터 선택된다. 따라서 신규의 아미노산 서열은 동일한 절단점 영역내로부터 아미노 및 카르복실 말단을 선택함으로써 생성된다. 많은 경우에 새로운 말단의 선택은 카르복실 말단의 원위치가 아미노 말단의 원위치에 바로 선행되도록 행해진다. 그러나, 당업자는 절단점 영역내의 어디서든지 말단을 선택할 수 있고, 이러한 선택은 새로운 서열의 아미노 또는 카르복실 부분에 대한 결실 또는 첨가를 효과적으로 유도하게 됨을 알 수 있을 것이다.

분자생물학의 중심 견해는 단백질의 1차 아미노산 서열이 그 생물학적 기능의 발현에 필요한 3차원 구조로의 폴딩을 지시한다는 것이다. 단일 단백질 결정의 x-선 회절 또는 단백질 용액의 핵자기공명분광법을 사용하여 3차원 구조 정보를 얻어서 해석하는 방법은 당업자에게 공지되어 있다. 절단점 영역의 동정과 관련된 구조 정보의 예로는 단백질 2차 구조의 위치 및 유형(알파 및 3-10 헬릭스, 평행 및 비평행 베타 시트, 사슬 반전 및 회전, 그리고 루프; Kabsch & Sander, Biopolymers 22: 2577-2637, 1983), 아미노산 잔기의 용매 노출도, 잔기들의 상호작용 정도 및 유형(Chothia, Ann. Rev. Biochem. 53:537-572, 1984) 그리고 폴리펩티드 사슬을 따르는 배좌의 정적 및 동적 분포(Alber & Mathews, Methods Enzymol. 154: 511-533, 1987)를 들 수 있다. 몇몇 경우에는 잔기의 용매 노출에 관한 추가 정보가 알려져 있다. 일례는 탄수화물의 번역후 부착 부위이고 이 부위는 반드시 단백질의 표면상에 있다. 실험적 구조 정보를 입수할 수 없을 때는, 1차 아미노산 서열을 분석하여 단백질 3차 및 2차 구조, 용매 접근가능성 및 회전 및 루프 발생률을 예측하는 방법도 또한 이용할 수 있다. 또한 직접 구조적 방법을 실행할 수 없을 때는 때때로 생화학적 방법을 표면 노출부의 경험적 결정에 적용할 수 있다. 예를 들어, 제한된 단백질분해 후에 사슬절단 부위를 동정하여 표면 노출부를 추측한다(Gentile & Salvatore, Eur. J. Biochem. 218:603-621, 1993).

따라서 실험적으로 얻어진 구조 정보 또는 예상 방법(예를 들면, Srinivisan & Rose Proteins: Struct., Funct. & Genetics, 22: 81-99, 1995)을 사용하여 모 아미노산 서열을 조사하여, 2차 및 3차 구조의 유지에 필수적인지의 여부에 따라 영역을 분류한다. 주기적 2차 구조(알파 및 3-10 헬릭스, 평행 및 비평행 베타 시트)와 관련된 것으로 알려진 영역내의 서열 발생은 피해야 한다. 마찬가지로, 용매 노출도가 낮은 것으로 관찰되거나 또는 예상되는 아미노산 서열의 영역은 단백질의 소위 소수성 코어의 일부가 되기 더 쉽고 또한 아미노 및 카르복실 말단의 선택을 위해서는 피해야 한다. 이와 달리, 표면 회전 또는 루프내에 있는 것으로 알려지거나 또는 예상되는 영역, 특히 생물학적 활성에 요구되지 않는 것으로 알려진 영역은 폴리펩티드 사슬의 맨끝 위치에 바람직한 부위이다. 바람직하게는 상기 기준에 의거한 아미노산 서열의 연속 스트레치를 절단점 영역이라 한다.

또한 다기능 키메라 조혈 수용체 아고니스트 단백질(예를 들면 폴리-His)의 정제 또는 동정을 용이하게 하기 위해 추가의 펩티드 서열이 첨가될 수 있다. 또한 고항원성 펩티드를 첨가하여 특정 모노클론성 항체에 의한 다기능 키메라 조혈 수용체 아고니스트 단백질의 신속한 분석 및 용이한 정제를 가능하게 할 수 있다.

"돌연변이 아미노산 서열", "돌연변이 단백질" "변이 단백질", "뮤테인" 또는 "돌연변이 폴리펩티드"는 아미노산 결실, 치환 또는 둘 다로 인해 천연 서열과 다르거나, 또는 천연 서열로부터 의도적으로 변이체로 만들어진 뉴클레오티드 서열에 의해 암호화되는 아미노산 서열을 갖는 폴리펩티드를 의미한다. "천연 서열"은 유전자 또는 단백질의 야생형 또는 천연 형태와 동일한 아미노산 또는 핵산 서열을 의미한다.

조혈성장인자는 사람 조혈 전구세포에 의한 콜로니 형성을 자극하는 능력에 의해 특성화될 수 있다. 형성되는 콜로니로는 적혈구, 과립구, 거핵구, 과립구성 대식세포 및 그것의 혼합물을 들 수 있다. 조혈성장인자의 다수는 초기에 영장류에 이어서 사람에서 수행된 연구에서 골수기능 및 말초혈 세포집단을 치료적으로 유리한 레벨로 회복하는 능력이 입증되었다. 조혈성장인자의 이들 생물학적 활성의 다수 또는 모두는 신호전달 및 고친화성 수용체 결합을 수반한다. 본 발명의 다기능 키메라 조혈 수용체 아고니스트는 단일 인자와 비교할 때 유사하거나 더 큰 생물학적 활성을 갖거나, 또는 개선된 반감기 또는 감소된 역부작용을 갖는 것과 같은 유용한 성질 또는 이들 성질의 조합을 나타낼 수 있다.

아고니스트 활성을 거의 갖지 않거나 전혀 갖지 않는 다기능 키메라 조혈 수용체 아고니스트는 길항제로서, 면역학 또는 면역요법에서 사용하기 위한 항체의 생성을 위한 항원으로서, 유전적 프로브로서 또는 다른 유용한 hIL-3 뮤테인을 구성하기 위해 사용되는 중간체로서 유용할 수 있다.

본 발명의 다기능 키메라 조혈 수용체 아고니스트 단백질의 생물학적 활성은 인자 의존성 세포계에서의 DNA 합성에 의해 측정되거나 또는 시험관내 골수 분석법으로 콜로니형성 유니트를 계수함으로써 측정될 수 있다.

본 발명의 다기능 키메라 조혈 수용체 아고니스트는 단일 작용 조혈 아고니스트와 비교하여 개선된 치료적 프로파일을 가질 수 있다. 예를 들면, 본 발명의 일부 다기능 키메라 조혈 수용체 아고니스트는 유사하거나 또는 대응하는 부작용의 증가 없이 다른 조혈 아고니스트에 비하여 유사하거나 또는 더 강력한 성장인자 활성을 가질 수 있다.

본 발명은 또한 다기능 키메라 조혈 수용체 아고니스트 단백질을 코딩하는 DNA 서열, 실질적으로 동일한 기능을 수행하는 실질적으로 유사한 DNA 서열, 및 단지 유전 코드의 축퇴로 인해 본 발명의 다기능 키메라 조혈 수용체 아고니스트를 암호화하는 DNA와 상이한 DNA 서열을 포함한다. 또한 본 발명은 돌연변이 DNA를 구성하는 데 사용되는 올리고뉴클레오티드 중간체 및 이들 올리고뉴클레오티드에 의해 코딩되는 폴리펩티드를 포함한다.

현재 당업계의 표준이 되고 있는 유전공학기술(미국 특허 제4,935,233호 및 Sambrook et al., "Molecular Cloning A Laboratory Manual" Cold Spring Harbor Laboratory, 1989)이 본 발명의 DNA 서열을 구성하는데 사용될 수 있다. 한가지 그러한 방법은 두개의 제한부위 사이의 유전자 부분에서 원하는 아미노산 치환을 암호화하는 합성 올리고뉴클레오티드로 플라스미드내 코딩 서열의 일부를 치환하는 카세트 돌연변이유발(Wells et al., Gene 34:315-323, 1985)이다.

원하는 유전자를 암호화하는 상보적 합성 올리고뉴클레오티드쌍을 제조하여 서로 어닐링시킬 수 있다. 올리고뉴클레오티드의 DNA 서열은 서열로부터 치환 및/또는 결실되는 것을 제외하고는 원하는 유전자의 아미노산에 대한 서열을 암호화할 것이다.

플라스미드 DNA를 선택된 제한 엔도뉴클레아제로 처리한 다음, 어닐링된 올리고뉴클레오티드에 라이게이션시킬 수 있다. 라이게이션된 혼합물을 사용하여 콤피턴트 JM101 세포를 적당한 항생물질에 대해 내성으로 형질전환시킬 수 있다. 단일 콜로니를 골라내고, 플라스미드 DNA를 제한분석 및/또는 DNA 서열화에 의해 시험하여 원하는 유전자를 갖는 플라스미드를 동정할 수 있다.

적어도 하나가 다른 콜로니 자극인자의 DNA 서열과 융합된 신규의 다기능 키메라 조혈 아고니스트의 DNA 서열의 클로닝은 중간체 벡터를 사용하여 달성될 수 있다. 대안으로 한 개의 유전자를 다른 유전자를 함유하는 벡터내로 직접 클로닝할 수 있다. 제한부위가 관심 있는 영역의 내부에 있는 경우에는, 링커 및 아댑터를 사용하여 DNA 서열을 결합할 수 있을 뿐만 아니라 결실된 서열을 대체할 수 있다. 따라서 한가지 폴리펩티드, 펩티드 링커 및 다른 폴리펩티드를 암호화하는 유전물질(DNA)을 박테리아, 효모, 곤충세포 또는 포유동물세포를 형질전환하는데 사용되는 적합한 발현벡터내로 삽입시킨다. 형질전환된 생물체를 성장시키고, 표준기술에 의해 단백질을 분리한다. 따라서 얻어지는 생성물은 링커영역에 의해 제 2 콜로니 자극인자에 결합된 콜로니자극인자를 갖는 새로운 단백질이다.

본 발명의 또 다른 양태는 이들 신규의 다기능 키메라 조혈 수용체 아고니스트의 발현에 사용하기 위한 플라스미드 DNA 벡터를 제공한다. 이들 벡터는 본 발명의 신규 폴리펩티드를 코딩하는 상기의 신규 DNA 서열을 함유한다. 다기능 키메라 조혈 수용체 아고니스트를 발현할 수 있는 미생물을 형질전환시킬 수 있는 적당한 벡터는 사용되는 숙주세포에 따라 선택된 전사 및 번역 조절서열에 결합된 다기능 키메라 조혈 수용체 아고니스트를 코딩하는 뉴클레오티드 서열을 포함하는 발현벡터를 포함한다.

상기와 같이 변형된 서열이 혼입된 벡터는 본 발명에 포함되며, 다기능 키메라 조혈 수용체 아고니스트 폴리펩티드의 제조에 유용하다. 그 방법에 사용되는 벡터는 또한 본 발명의 DNA 코딩 서열과 작동가능하게 회합된 선택된 조절서열을 함유하며, 선택된 숙주세포에서 그것의 복제 및 발현을 지시할 수 있다.

본 발명의 또 다른 양태로서, 신규의 다기능 키메라 조혈 수용체 아고니스트를 제조하는 방법이 제공된다. 본 발명의 방법은 신규의 다기능 키메라 조혈 수용체 아고니스트의 발현을 코딩하는 DNA 서열을 함유하는 벡터로 형질전환된 적합한 세포 또는 세포계를 배양하는 것을 수반한다. 적합한 세포 또는 세포계는 박테리아 세포일 수 있다. 예를 들어, E. coli의 각종 균주가 생물공학분야에서 숙주세포로 잘 알려져 있다. 그러한 균주의 예로는 E. coli 균주 JM101(Yanish-Perron et al. Gene 33: 103-119, 1985) 및 MON105(Obukowicz et al., Applied Environmental Microbiology 58: 1511-1523, 1992)를 들 수 있다. 또한 본 발명에는 박테리오파지 Mu에 기초한 E. coli용 염색체 발현벡터를 사용한 다기능 키메라 조혈 수용체 아고니스 단백질의 발현이 포함된다(Weinberg et al., Gene 126: 25-33, 1993). B. subtilis의 각종 균주도 또한 본 방법에 사용될 수 있다. 당업자에게 공지된 효모 세포의 많은 균주도 또한 본 발명의 폴리펩티드를 발현시키기 위한 숙주세포로서 이용가능하다. E. coli 세포질에서 발현될 때, 본 발명의 다기능 키메라 조혈 수용체 아고니스트를 암호화하는 유전자는 또한 유전자 코돈의 5' 말단에 첨가되어 단백질의 N-말단에서 Met^-2-Ala^-1- 또는 Met^-1을 암호화하도록 구성될 수 있다. E. coli의 세포질에서 만들어진 단백질의 N-말단은 메티오닌 아미노펩티다제(Ben Bassat et al., J. Bac. 169:751-757, 1987)에 의한 그리고 가능하면 다른 펩티다제에 의한 번역후 프로세싱에 의해 영향을 받는다. 본 발명의 다기능 키메라 조혈 수용체 아고니스트는 N-말단에서 Met^-1, Ala^-1 또는 Met^-2-Ala^-1을 갖는 다기능 키메라 조혈 수용체 아고니스트 폴리펩티드를 포함할 수 있다. 이들 돌연변이 다기능 키메라 조혈 수용체 아고니스트는 또한 분비신호펩티드를 N-말단에 융합시킴으로써 E. coli에서 발현될 수 있다. 이 신호펩티드는 분비과정의 일부로서 폴리펩티드로부터 절단된다. E. coli에서 유전자의 고레벨 발현을 달성하는 추가의 방법은 Savvas, C.M.(Microbiological Reviews 60;512-538, 1996)에서 찾아볼 수 있다.

또한 중국산 햄스터 난소세포(CHO)와 같은 포유동물 세포도 본 발명에서의 사용에 적합하다. 포유동물 세포에서의 외부 유전자의 발현을 위한 일반적인 방법은 Kaufman, R. J., 1987, Genetic Engineering, Principles and Methods, Vol. 9, J. K. Setlow, editor, Plenum Press, New York에 검토되어 있다. 포유동물 세포에서 기능할 수 있는 강한 프로모터가 다기능 키메라 조혈 수용체 아고니스트의 코딩영역에 번역적으로 결합되는 진핵 분비신호펩티드 코딩영역의 전사를 시동하는 발현 벡터을 구성한다. 예를 들어 pcDNA I/Neo, pRc/RSV 및 pRc/CMV(Invitrogen Corp., San Diego, California로부터 구함)를 사용할 수 있다. 진핵 분비신호펩티드 코딩영역은 유전자 자체로부터 유래될 수 있거나, 또는 또 다른 분비된 포유동물 단백질로부터 유래될 수 있다(Bayne, M. L. et al., Proc. Natl. Acad. Sci. USA 84: 2638-2642, 1987). 유전자를 함유하는 벡터의 구성 후에, 벡터 DNA를 포유동물 세포내로 트랜스펙션시킨다. 그러한 세포는 예컨대 COS7, HeLa, BHK, CHO 또는 마우스 L 라인이 될 수 있다. 세포는 예를 들어 DMEM 배지(JRH Scientific)에서 배양할 수 있다. 배지로 분비된 폴리펩티드는 세포의 트랜스펙션 후 24-72시간 동안 일시적으로 발현시킨 후에 또는 항생물질 내성에 대한 선택 후 안정한 세포계를 수립한 후에 표준 생화학적 접근법에 의해 회수할 수 있다. 적합한 포유동물 숙주세포의 선택과 형질전환, 배양, 증폭, 스크리닝 및 생성물 생산 및 정제를 위한 방법은 당업계에 공지되어 있다. 예를 들면, Gething and Sambrook, Nature, 293:620-625, 1981, 또는 선택적으로 Kaufman et al, Mol. Cell. Biol., 5(7):1750-1759, 1985 또는 Howley et al., 미국 특허 제4,419,446호 참조. 또 다른 적합한 포유동물 세포계는 원숭이 COS-1 세포계이다. 마찬가지로 유용한 포유동물 세포계는 CV-1 세포계이다.

원한다면, 곤충세포를 본 발명의 방법에서 숙주세포로서 사용할 수 있다. 예를 들면, Miller et al., Genetic Engineering, 8:277-298 (Plenum Press 1986) 및 거기에 인용된 참고문헌 참조. 더욱이 바큘로바이러스 벡터를 사용한 곤충세포에서의 외부유전자 발현을 위한 일반적인 방법은 Summers, M. D. and Smith, G. E., 1987 - A manual of methods for Baculovirus vectors and insect cell culture procedures, Texas Agricultural Experiment Station Bulletin No. 1555에 기재되어 있다. 강한 바큘로바이러스 프로모터(폴리헤드론 프로모터와 같은)가 다기능 키메라 조혈 수용체 아고니스트 폴리펩티드를 위한 코딩영역에 번역적으로 결합되는 진핵 분비신호펩티드 코딩영역의 전사를 시동하는 바큘로바이러스 전달 벡터를 포함하는 발현벡터를 구성한다. 예를 들면, 플라스미드 pVL1392(Invitrogen Corp., San Diego, California로부터 구함)를 사용할 수 있다. 다기능 키메라 조혈 수용체 아고니스트 폴리펩티드를 암호화하는 유전자를 포함하는 벡터의 구성 후에, 2마이크로그램의 이 DNA를 1마이크로그램의 바큘로바이러스 DNA와 함께 곤충세포, 균주 SF9로 공동트랜스펙션시킨다(Summers & Smith, 1987 참조). 다기능 키메라 조혈 수용체 아고니스트를 포함하는 순수한 재조합 바큘로바이러스를 사용하여 예컨대 Excell 401 무혈청 배지(JRH Biosciences, Lenexa, Kansas)에서 배양된 세포를 감염시킨다. 배지내로 분비된 다기능 키메라 조혈 수용체 아고니스트는 표준 생화학적 접근법에 의해 회수할 수 있다. 다기능 키메라 조혈 수용체 아고니스트 단백질을 발현하는 포유동물 또는 곤충 세포로부터의 상청액은 다수의 시판 농축유니트 중 어느 것을 사용하여 우선 농축시킬 수 있다.

본 발명의 다기능 키메라 조혈 수용체 아고니스트는 조혈시스템의 골수양, 적혈구양, 림프양 또는 거핵구 세포 또는 그것의 조합의 저하된 레벨을 특징으로 하는 질병의 치료에 유용할 수 있다. 더욱이 이들은 성숙 골수양 및/또는 림프양 세포를 활성화하기 위해 사용될 수 있다. 본 발명의 폴리펩티드에 의한 치료를 받기 쉬운 상태중에는 말초혈중의 순환 백혈구(백색세포)의 수가 감소되는 백혈구감소증이 있다. 백혈구감소증은 일정한 바이러스에 또는 방사선에의 노출에 의해 유발될 수 있다. 그것은 종종 다양한 형태의 암요법, 예컨대 화학요법약, 방사선에의 노출과 감염 또는 출혈의 부작용이다. 본 발명의 이들 다기능 키메라 조혈 수용체 아고니스트에 의한 백혈구감소증의 치료적 처치는 현재 구할 수 있는 약품에 의한 치료에 의해 유발되는 바람직하지 않은 부작용을 피할 수 있다.

본 발명의 다기능 키메라 조혈 수용체 아고니스트는 호중구감소증의 치료에 그리고 예컨대 무형성 빈혈, 주기성 호중구감소증, 자발성 호중구감소증, Chediak -Higashi 증후근, 전신성 홍반낭창(SLE), 백혈병, 골수이형성증후군 및 골수섬유증과 같은 상태의 치료에 유용할 수 있다.

본 발명의 다기능 키메라 조혈 수용체 아고니스트는 혈소판감소증의 치료 또는 예방에 유용할 수 있다. 현재 혈소판감소증에 대한 유일한 치료법은 값비싸고 감염(HIV, HBV) 및 동종면역화를 일으킨 위험이 큰 혈소판 수혈이다. 다기능 키메라 조혈 수용체 아고니스트는 혈소판 수혈의 필요성을 완화 또는 감소시킬 수 있다. 심각한 혈소판감소증은 Fanconi 빈혈, Wiscott-Aldrich 또는 May Hegglin 증후군과 같은 유전적 결함으로부터 초래될 수 있다. 후천성 혈소판감소증은 면역 혈소판감소성 자반병, 전신성 홍반낭창, 용혈성 빈혈 또는 태아 모체 부적합성에서와 같은 자기 또는 동종 항체로부터 초래될 수 있다. 더욱이, 거비증, 파종성 맥관내 응혈, 혈전성 혈소판감소성 자반병, 감염 또는 인공심장판막도 혈소판감소증을 초래할 수 있다. 심각한 혈소판감소증은 또한 암의 화학요법 및/또는 방사선요법으로부터 초래될 수 있다. 혈소판감소증은 또한 암, 림프종, 백혈병 또는 섬유증에 의한 골수 침입으로부터 초래될 수 있다.

본 발명의 다기능 키메라 조혈 수용체 아고니스트는 말초혈내의 조혈전구체 및 간세포의 가동화에 유용할 수 있다. 말초혈 유래 전구체는 자가 골수이식의 세팅에서 환자를 재생시키는데 효과적이라고 밝혀졌다. G-CSF 및 GM-CSF를 포함하는 조혈성장인자는 말초혈중의 순환 전구체 및 간세포의 수를 증가시킨다고 밝혀졌다. 이것은 말초 간세포 수집을 위한 절차를 단순화하고, 필요한 페레시스(pheresis)의 수를 감소시킴으로써 절차의 비용을 급격히 감소시켰다. 다기능 키메라 조혈 수용체 아고니스트는 간세포의 가동화에 유용하고, 또한 말초 간세포 이식의 효율을 향상시킬 수 있다.

본 발명의 다기능 키메라 조혈 수용체 아고니스트는 또한 조혈 전구체 및 간세포의 생체외 증량(expansion)에 유용할 수 있다. hIL-3과 같은 콜로니자극인자(CSF)는 종종 고투여량 화학요법의 결과인 호중구감소증 및 혈소판감소증을 치료하기 위해 고투여량 화학요법에 후속하여 단독으로 투여되거나 다른 CSF와 함께 투여되거나 골수이식과 병용하여 투여되어 왔다. 그러나 심한 호중구감소증 및 혈소판감소증을 앓는 기간을 전부 없앨 수는 없다. 단핵구(대식세포), 과립구(호중구를 포함) 및 거핵구로 이루어지는 골수양 계통은 생명을 위협할 수 있는 감염 및 출혈을 예방하는데 있어서 중요하다. 호중구감소증은 또한 질환, 유전병, 약물, 독소, 방사선 및 종래의 종양요법과 같은 많은 치료적 처치의 결과일 수도 있다.

골수이식이 이러한 환자집단을 치료하는데 사용되어 왔다. 그러나, 1) 골수, 비장 또는 말초혈내의 간세포수 제한, 2) 대숙주성 이식편병, 3) 이식편 거부 및 4) 종양세포에 의한 오염 가능성을 포함한 몇가지 문제가 손상된 조혈 시스템을 재현하는데 골수를 사용하는 것과 관련되어 있다. 간세포는 골수, 비장 및 말초혈내에서 아주 작은 비율의 유핵 세포를 생성한다. 투여량 반응은 다수의 간세포가 조혈 회복을 향상시키도록 나타난다는 것이 명백하다. 따라서, 간세포의 시험관내 증량은 조혈 회복 및 환자 생존률을 향상시켜야 한다. 동종 공여자로부터의 골수가 이식용 골수를 제공하는데 사용되어 왔다. 그러나, 대숙주성 이식편병 및 이식편 거부는 HLA가 들어맞는 동기 공여자에 의한 수용자에서도 골수이식을 제한한다. 동종 골수이식에 대한 대안은 자가 골수이식이다. 자가 골수이식에서는 환자 자신의 골수 중 일부를 골수아구요법, 예컨대 고투여량 화학요법 전에 수거하고, 그 후 환자에게 다시 이식한다. 자가 이식은 대숙주성 이식편병 및 이식편 거부의 위험이 없다. 그러나, 자가 골수이식은 골수내의 간세포수 제한 및 종양세포에 의한 오염 가능성의 면에서 여전히 문제가 있다. 간세포수의 제한은 간세포의 생체외 증량에 의해 극복될 수 있다. 더욱이 간세포는 골수이식편의 종양세포 오염을 감소시키기 위해 CD34+와 같은 특이적 표면 항원의 존재에 기초하여 특이적으로 분리될 수 있다.

다음 특허는 간세포인 CD34+ 세포의 분리, 이 세포를 조혈인자와 함께 배양하는 것, 조혈성 장애가 있는 환자의 치료를 위한 상기 세포의 사용 및 세포 증량과 유전자요법을 위한 조혈인자의 사용에 관한 더 상세한 내용을 포함하고 있다.

5,061,620은 전용 세포로부터 간세포를 분리함으로써 제공되는 사람 조혈 간세포를 포함하는 조성물에 관한 것이다.

5,199,942에는 (1) 환자로부터 조혈 전구세포를 얻고; (2) IL-3, flt3 리간드, c-kit 리간드, GM-CSF, IL-1, GM-CSF/IL-3 융합단백질 및 그것의 조합으로 이루어지는 군으로부터 선택된 성장인자에 의해 세포를 생체외에서 증량하고; (3) 세포 제제를 환자에게 투여하는 것으로 이루어지는 자가 조혈세포 이식방법이 기재되어 있다.

5,240,856은 세포분리공정을 자동으로 제어하는 장치를 포함하는 세포분리기에 관한 것이다.

WO 91/16116에는 세포 혼합물로부터 표적 세포를 선택적으로 단리 및 분리하는 장치 및 방법이 기재되어 있다.

WO 91/18972에는 중공의 섬유 생물반응기를 사용하여 골수 세포의 현탁액을 배양함으로써 골수를 시험관내에서 배양하는 방법이 기재되어 있다.

WO 92/18615는 이식에 사용하기 위해 시토카인의 특정 혼합물을 함유하는 배양배지에서 골수 세포를 유지 및 증량하는 방법에 관한 것이다.

WO 93/08268에는 (a) CD34+ 간세포를 다른 세포로부터 분리하는 단계 및 (b) 분리된 세포를 선택적 배지에서 배양하여 간세포가 선택적으로 증량되도록 하는 단계로 이루어지는, 간세포를 선택적으로 증량하는 방법이 기재되어 있다.

WO 93/18136에는 말초혈로부터 유래되는 포유동물 세포의 시험관내 지지방법이 기재되어 있다.

WO 93/18648은 유전성 또는 후천성 호중구감소증을 치료하기 위한, 고농도의 골수아구 및 전골수구와 함께 사람 호중성 전구세포를 포함하는 조성물에 관한 것이다.

WO 94/08039에는 c-kit 단백질을 발현하는 세포의 선택에 의해 사람 조혈 간세포를 강화하는 방법이 기재되어 있다.

WO 94/11493에는 역류경사법을 사용하여 분리된, CD34+이고 크기가 작은 간세포 집단이 기재되어 있다.

WO 94/27698은 유핵 이종세포 집단을 이종세포 혼합물로부터 선택적으로 분리하기 위해 면역친화성 분리와 연속 유동원심분리를 병용하는 방법에 관한 것이다.

WO 94/25848에는 표적 세포의 수집 및 조작을 위한 세포분리장치가 기재되어 있다.

IL-1a, IL-3, IL-6 또는 GM-CSF를 함유하는 배양물에서 사람 골수로부터의 조혈 전구세포의 고도로 강화된 CD34+ 전구체를 장기간 배양하는 것은 Brandt et al J. Clin. Invest. 86:932-941, 1990에 논의되어 있다.

본 발명의 한 양태는 간세포의 선택적 생체외 증량방법을 제공한다. 용어 "간세포"는 전능 조혈 간세포 뿐만 아니라 골수, 비장 또는 말초혈로부터 분리될 수 있는 초기전구체 및 전구세포를 말한다. 용어 "증량"은 세포의 분화 및 증식을 말한다. 본 발명은 (a) 간세포를 다른 세포로부터 분리하는 단계, (b) 상기 분리된 간세포를, 다기능 키메라 조혈 수용체 아고니스트 단백질(들)을 함유하는 선택적 배지와 함께 배양하는 단계 및 (c) 상기 간세포를 수거하는 단계로 이루어지는, 간세포의 선택적 생체외 증량방법을 제공한다. 간세포 뿐만 아니라, 호중구, 적혈구, 혈소판 등이 될 운명에 있는 수임 전구세포도 이들 세포의 표면상에 존재하는 CD34와 같은 특정 전구체 마커 항원의 존재 또는 부재에 의해 및/또는 형태학적 특성에 의해 대부분의 다른 세포와 구별될 수 있다. 고도로 강화된 사람 간세포 분획에 대한 표현형은 CD34+, Thy-1+ 및 lin-로서 보고되어 있으나, 본 발명이 이 간세포 집단의 증량에 한정되지 않음은 물론이다. CD34+ 강화된 사람 간세포 분획은 CD34+와 같은 표면항원에 관한 항체를 사용한 친화성 칼럼 또는 비드, 자기 비드 또는 유동세포계산을 포함하는 다수의 보고된 방법에 의해 분리될 수 있다. 또한, 역류경사법과 같은 물리적 분리방법을 사용하여 조혈 전구체를 강화시킬 수 있다. CD34+ 전구체는 이종성이며, 상이한 계통 회합 세포표면 회합 분자의 공동발현의 존재 또는 부재에 의해 특징지어지는 몇가지 하위집단으로 나누어질 수 있다. 대부분의 미성숙한 전구세포는 HLA-DR 또는 CD38과 같은 어떤 공지된 계통 회합 마커도 발현시키지 않으나 CD90(thy-1)을 발현시킬 수 있다. CD33, CD38, CD41, CD71, HLA-DR 또는 c-kit와 같은 다른 표면항원도 또한 조혈 전구체를 선택적으로 분리하는데 사용될 수 있다. 분리된 세포는 배양 플라스크, 멸균 백 또는 중공 섬유내의 선택된 배지에서 배양될 수 있다. 각종 콜로니자극인자가 세포를 선택적으로 증량시키기 위해 사용될 수 있다. 골수의 생체외 증량에 사용되어 온 대표적인 인자로는 c-kit 리간드, IL-3, G-CSF, GM-CSF, IL-1, IL-6, IL-11, flt-3 리간드 또는 그것의 조합을 들 수 있다. 간세포의 증식은 배양 전후에 표준 기법(예를 들면 혈색소계, CFU, LTCIC)에 의해 또는 유동세포계에 의해 간세포 및 다른 세포의 수를 셈으로써 모니터할 수 있다.

간세포의 생체외 증량을 위한 몇가지 방법이 보고되었는데 이 방법들은 c-kit 리간드(Brandt et al., Blood 83:1507-1514 [1994], McKenna et al., Blood 86:3413-3420 [1995]), IL-3(Brandt et al., Blood 83:1507-1514 [1994], Sato et al., Blood 82:3600-3609 [1993]), G-CSF(Sato et al., Blood 82:3600-3609 [1993]), GM-CSF(Sato et al., Blood 82:3600-3609 [1993]), IL-1(Muench et al., Blood 81:3463-3473 [1993]), IL-6(Sato et al., Blood 82:3600-3609 [1993]), IL-11(Lemoli et al., Exp. Hem. 21:1668-1672 [1993], Sato et al., Blood 82:3600-3609 [1993]), flt-3 리간드(McKenna et al., Blood 86:3413 3420 [1995]) 및/또는 그것의 조합(Brandt et al., Blood 83:1507 1514 [1994], Haylock et al., Blood 80:1405-1412 [1992], Koller et al., Biotechnology 11:358-363 [1993], Lemoli et al., Exp. Hem. 21:1668-1672 [1993], McKenna et al., Blood 86:3413-3420 [1995], Muench et al., Blood 81:3463-3473 [1993], Patchen et al., Biotherapy 7:13-26 [1994], Sato et al., Blood 82:3600-3609 [1993], Smith et al., Exp. Hem. 21:870-877 [1993], Steen et al., Stem Cells 12:214-224 [1994], Tsujino et al., Exp. Hem. 21:1379-1386 [1993])을 포함하는 각종 콜로니자극인자를 사용한 간세포의 증량 및 다수의 선택방법을 이용한다. 각 콜로니자극인자 중에서, hIL-3은 말초혈 CD34+ 세포를 증량시키는데 있어서 가장 강력한 것 중 하나인 것으로 밝혀졌다(Sato et al., Blood 82:3600-3609 [1993], Kobayashi et al., Blood 73:1836-1841 [1989]). 그러나, 단일 인자는 다중 인자의 조합물 만큼 효과적이지 못한 것으로 밝혀졌다. 본 발명은 단일 인자 단독보다 더 효과적인 다기능 키메라 조혈 수용체 아고니스트를 사용하는 생체외 증량방법을 제공한다.

본 발명의 또 다는 양태는 조혈 전구세포의 유지 및/또는 증량방법으로서, 본 발명의 다기능 키메라 조혈 수용체 아고니스트로 보충된 HS-5(WO 96/02662, Roecklein and Torok-Strob, Blood 85:997-1105, 1995)와 같은 스트로마 세포계에 노출시켜 조절된 배양배지를 함유하는 배양용기에 세포를 접종시키는 것을 포함하는 방법을 제공한다.

또한 본 발명의 다기능 키메라 조혈 수용체 아고니스트의 용도는 혈액 보관 용도를 포함하는 것으로 예상되고, 이 경우 EPO 수용체 아고니스트를 환자에게 투여하여 혈액세포의 수를 증가시키고 어떤 의학적 시술전에 혈액제제를 환자로부터 제거한다. 혈액제제를 저장하고 의학적 시술후에 환자에게 다시 수혈한다. 또한, 다기능 키메라 조혈 수용체 아고니스트의 용도는 공혈전에 공혈자에게 본 다기능 키메라 조혈 수용체 아고니스트를 투여하여 혈액세포의 수를 증가시킴으로써 공혈자가 보다 많은 혈액을 안전하게 제공할 수 있게 하는 것을 포함하는 것으로 예상된다.

성장인자의 또 다른 예측되는 임상용도는 유전자요법을 위한 조혈 전구체 및 간세포의 시험관내 활성화에 있었다. 조혈 전구세포의 긴 수명 및 그것의 낭세포의 전신에 걸친 분포로 인해, 조혈 전구세포는 생체외 유전자 트랜스펙션을 위한 양호한 후보가 된다. 조혈 전구체 또는 간세포의 게놈내로 관심 있는 유전자를 통합시키기 위해서는 세포분열 및 DNA 복제를 자극할 필요가 있다. 조혈 간세포는 매우 낮은 빈도로 순환하며, 이는 성장인자가 유전자 형질도입을 촉진하는데 유용하여 유전자요법의 임상적 전망을 향상시킬 수 있다는 것을 의미한다. 유전자 요법(Crystal, Science 270:404-410 [1995] 참조)의 잠재적 용도로는 1) 많은 선천성 대사장애 및 면역결핍(Kay and Woo, Trends Genet. 10:253-257 [1994]), 2) 신경계장애(Friedmann, Trends Genet. 10:210-214 [1994]), 3) 암(Culver and Blaese, Trends Genet. 10:174-178 [1994]) 및 4) 감염병(Gilboa and Smith, Trends Genet. 10:139-144 [1994])의 치료를 들 수 있다.

유전 물질을 숙주세포에 도입하는, 당업자에게 공지된 방법은 여러가지가 있다. 바이러스성 및 비바이러스성의 다수의 벡터가 치료적 유전자를 1차 세포내로 전달하기 위해 개발되어 왔다. 바이러스계 벡터로는 복제결핍 재조합 레트로바이러스(Boris-Lawrie and Temin, Curr. Opin. Genet. Dev. 3:102-109 [1993], Boris-Lawrie and Temin, Annal. New York Acad. Sci. 716:59-71 [1994], Miller, Current Top. Microbiol. Immunol. 158:1-24 [1992])및 복제결핍 재조합 아데노바이러스(Berkner, BioTechniques 6:616-629 [1988], Berkner, Current Top. Microbiol. Immunol. 158:39-66 [1992], Brody and Crystal, Annal. New York Acad. Sci. 716:90-103 [1994])를 들 수 있다. 비바이러스계 벡터로는 단백질/DNA 복합체(Cristiano et al., PNAS USA. 90:2122-2126 [1993], Curiel et al., PNAS USA 88:8850-8854 [1991], Curiel, Annal. New York Acad. Sci. 716:36-58 [1994]), 양이온성 리포솜과 같은 전기영동 및 리포솜 매개 전달물(Farhood et al., Annal. New York Acad. Sci. 716:23-35 [1994])을 들 수 있다.

본 발명은 어떤 단일 콜로니자극인자에 의해서도 나타나지 않는 활성을 포함하여 개선된 생물학적 활성을 갖는 다기능 키메라 조혈 수용체 아고니스트를 사용한다는 점에서, 새로운 유전 물질을 도입해 온 조혈세포를 증량시키는 기존 방법에 대한 개선을 제공한다.

많은 약품들이 골수 억제 또는 조혈 결함을 초래할 수 있다. 그러한 약품의 예로는 화학요법에 사용되는 AZT, DDI, 알킬화제 및 항대사물질, 클로람페니콜, 페니실린, 간시클로비르, 다우노마이신 및 술파약품과 같은 항생제, 페노티아존, 메프로바메이트와 같은 정신안정제, 아미노피린 및 디피론과 같은 진통제, 페니토인 또는 카르바마제핀과 같은 진경제, 프로필티오우라실 및 메티마졸과 같은 항갑상선제 그리고 이뇨제이다. 본 발명의 다기능 키메라 조혈 수용체 아고니스트는 이들 약품으로 치료된 환자에서 종종 발생하는 골수 억제 또는 조혈 결함을 예방 또는 치료하는데 유용할 수 있다.

조혈 결함은 또한 바이러스, 미생물 또는 기생물 감염, 화상의 결과로서 그리고 신장질환 또는 신부전의 치료, 예컨대 투석의 결과로서 발생할 수 있다. 본 발명의 다기능 키메라 조혈 수용체 아고니스트는 그러한 조혈 결함을 치료하는데 유용할 수 있다.

조혈 결함의 치료는 다기능 키메라 조혈 수용체 아고니스트를 함유하는 약학적 조성물을 환자에게 투여하는 것을 포함할 수 있다. 또한 본 발명의 다기능 키메라 조혈 수용체 아고니스트는 본 발명의 다기능 키메라 조혈 수용체 아고니스트 단백질로 이들 세포를 시험관내에서 처리한 후 세포를 환자에게 주사함으로써 조혈 전구세포를 활성화 및 증폭시키는데 유용할 수 있다.

또한 예컨대 T 및/또는 B 림프구에서의 다양한 면역결핍, 또는 면역장애, 예컨대 류마티스양 관절염도 본 발명의 다기능 키메라 조혈 수용체 아고니스트에 의한 치료에 의해 유리한 영향을 받을 수 있다. 면역결핍은 예를 들어 HTLVI, HTLVII, HTLVIII과 같은 바이러스감염, 방사선, 암요법에의 심한 노출 또는 다른 의학적 치료의 결과일 수 있다. 또한 본 발명의 다기능 키메라 조혈 수용체 아고니스트는 혈소판감소증(혈소판결핍)을 포함한 다른 혈액세포결핍 또는 빈혈의 치료에서 단독으로 또는 다른 콜로니자극인자와 조합하여 사용될 수 있다. 이들 신규의 폴리펩티드에 대한 다른 용도는 골수이식으로부터 회복하는 환자의 생체내 및 생체외 치료에 그리고 진단 또는 치료적 용도를 위한 표준방법에 의해 생성되는 모노클론성 및 폴리클론성 항체의 발생에 있다.

본 발명의 또 다른 양태는 상기에 언급된 상태들을 치료하는 방법 및 치료 조성물이다. 그러한 조성물은 약학적으로 허용되는 담체와의 혼합물로 치료적 유효량의 본 발명의 한가지 이상의 다기능 키메라 조혈 수용체 아고니스트를 포함한다. 이 조성물은 비경구적으로, 정맥내로 또는 피하로 투여될 수 있다. 투여될 때, 본 발명에서 사용하기 위한 치료 조성물은 바람직하게는 발열물질 없는, 비경구적으로 허용되는 수용액의 형태이다. pH, 등장성, 안정성 등이 충분히 고려된 비경구적으로 허용되는 단백질 용액의 제제는 당업계의 통상의 기술범위내에 있다.

본 발명의 다기능 키메라 조혈 수용체 아고니스트의 또 다른 의도된 용도는 면역화를 위한 보조제로서 사용될 다수의 수상세포를 전구체로부터 생성하는 것이다. 수상세포는 면역계에서 매우 중요한 역할을 한다. 수상세포는 정지 T 세포의 활성화에 가장 유효한 전문적 항원제공 세포이고 생체내에서 천연 T 세포의 활성화 및 1차 면역반응의 개시를 위한 중요한 항원제공 세포이다. 수상세포는 효과적으로 세포내에 이입되고 처리되어 가용성의 종양 특이적 항원(Ag)을 제공한다. 수상세포는 천연 T 세포를 모으고 주조직적합체(MHC) 및 공동자극분자 발현의 신속한 상향조절, 시토카인의 생성 및 림프기관쪽으로의 이동에 의해 Ag 인카운터에 대해 반응하는 능력을 갖고 있다. 수상세포는 CD4- 의존성 면역반응에 대한 새 항원에 대해 숙주를 감작시키기 위해 매우 중요한 것이므로, 수상세포는 또한 종양면역의 발생 및 조절에 있어서도 매우 중요한 역할을 할 수 있다.

수상세포는 과립구 및 대식세포에 공통적인 골수 CD34+ 전구체로부터 유래하고, 순수한 수상세포 콜로니를 생성하는 독립된 수상세포 콜로니형성 유니트(CFU-DC)의 존재가 사람에서 입증되었다. 더욱이, 별개의 시토카인 조건 하에서 수상세포 또는 대식세포 경로에 따라 분화되는 잠재력을 갖는 후-CFU CD14+ 중간체가 기재되었다. 이러한 이중잠재성의 전구체는 골수, 제대혈 및 말초혈에 존재한다. 배양된 수상세포의 성숙을 설명하기 위해 수상세포는 CD1a+, CD3-, CD4-, CD20-, CD40+, CD80+ 및 CD83+와 같은 특이적 세포표면 마커에 의거하여 분리될 수 있다.

수상세포에 의거한 방법은 종양 및 감염인자에 대한 면역반응을 향상시키는 방법을 제공한다. 수상세포는 HIV-1 복제를 촉진시키는데 있어서 중요한 역할을 할 수 있으므로 AIDS는 수상세포에 의거한 요법이 사용될 수 있는 또 하나의 질환이다. 면역요법은 암환자로부터 수상세포를 생성하고, 그것을 수술로 제거된 종양덩어리로부터 유래되는 종양 Ag에 시험관내에서 노출시키고, 이들 세포를 종양 환자에게 다시 주입할 것을 요한다.

종양세포의 비교적 거친 멤브레인 제제는 종양항원의 공급원으로서 충분하여, 종양항원의 분자 동정이 필요없게 된다. 종양항원은 또한 합성 펩티드, 탄수화물 또는 핵산서열일 수 있다. 또한, 본 발명의 다기능 키메라 조혈 수용체 아고니스트와 같은 시토카인의 공동투여는 종양 면역성의 유도를 더 용이하게 할 수 있다. 면역요법은 본 발명의 다기능 키메라 조혈 수용체 아고니스트를 단독으로 또는 다른 조혈성장인자와 함께 종양 환자에게 투여하여 수상세포의 수를 증가시키고 내인성 종양항원을 수상세포상에 존재시키는 생체내 세팅일 수 있는 것으로 예견된다. 또한 생체내 면역요법은 외인성 항원에 의할 수도 있는 것으로 예상된다. 또한 면역요법 치료는 본 발명의 다기능 키메라 조혈 수용체 아고니스트를 단독으로 또는 다른 조혈성장인자와 함께 환자에게 투여하고, 수상세포 전구체 또는 성숙 수상세포를 환자로부터 제거하고, 수상세포를 항원에 노출시키고, 수상세포를 환자에게 복귀시킴으로써 수상세포 전구체 또는 성숙 수상세포의 가동화를 포함할 수 있는 것으로 예상된다. 더욱이, 제거된 수상세포는 항원에의 노출에 앞서서 수상세포의 수를 증가시키기 위해 본 발명의 다기능 키메라 조혈 수용체 아고니스트 단독과 함께 또는 다른 조혈성장인자와 함께 생체외에서 배양될 수 있다. 수상세포에 의거한 방법은 또한 자가면역질환에서 면역반응을 감소시키는 방법을 제공한다.

수상세포에 관한 연구는 수상세포를 충분한 수로 그리고 합리적으로 순수한 형태로 제조하는데 있어서의 어려움에 의해 방해를 받아 왔다. 생채외 세포증량 세팅에서, 과립구-대식세포, 콜로니자극인자(GM-CSF) 및 종양괴사인자-α(TNF-α)는 골수, 제대혈 또는 말초혈로부터 회수되는 조혈 전구체(CD34+ 세포)로부터의 수상세포의 생체외 생성을 돕고 flk-2/flt-3 리간드 및 c-kit 리간드(간세포 인자[SCF])는 수상세포의 GM-CSF 및 TNF-α 유도 생성을 향상시키도록 상승작용한다(Siena, S. et al. Experimental Hematology 23:1463-1471, 1995). 또한 면역요법에 충분한 양의 수상세포를 제공하기 위해 본 발명의 다기능 키메라 조혈 수용체 아고니스트를 사용하여 수상세포 전구체 또는 성숙 수상세포의 생체외 증량방법이 제공된다.

상기 상태들을 치료하는 방법에 관련된 투여량 섭생은 약품의 작용을 변형시키는 다양한 요인들, 예컨대 환자의 상태, 체중, 성별 및 식이요법, 어떤 감염의 심한 정도, 투여시간 및 다른 임상적 요인을 고려하여 주치의에 의해 결정된다. 일반적으로 일일 섭생은 체중의 킬로그램당 0.2-150㎍/㎏의 다기능 키메라 조혈 수용체 아고니스트 단백질의 범위내일 수 있다. 투여량은 주어진 다기능 키메라 조혈 수용체 아고니스트 단백질의 활성에 관련하여 조절될 것이며, 투여량 섭생이 일당 체중의 킬로그램당 0.1마이크로그램만큼 적고 1밀리그램만큼 많은 투여량을 포함할 수 있다고 인식하는 것은 비합리적이지 않을 것이다. 더욱이 다기능 키메라 조혈 수용체 아고니스트의 투여량이 체중의 킬로그램당 0.2-150마이크로그램의 범위보다 더 많거나 적게 조정될 수 있는 특정 상황이 존재할 수도 있다. 이들은 다른 콜로니자극인자 또는 IL-3 변이체 또는 성장인자와의 병용투여; 화학요법적 약품 및/또는 방사선과의 병용투여; 글리코실화된 다기능 키메라 조혈 수용체 아고니스트 단백질의 사용; 및 이 섹션에서 앞서 언급된 다양한 환자 관련 문제를 포함한다. 상기한 바와 같이, 치료방법 및 조성물은 또한 다른 사람인자와의 병용투여를 포함할 수 있다. 본 발명의 폴리펩티드와의 동시적 또는 순차적 병용투여를 위한 다른 적당한 콜로니자극인자(CSF), 시토카인, 림포카인, 조혈성장인자 및 인터루킨의 비배타적 리스트는 GM-CSF, G-CSF, c-mpl 리간드(TPO 또는 MGDF로도 알려짐), M-CSF, 에리트로포이에틴(EPO), IL-1, IL-4, IL-2, IL-3, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, IL-16, LIF, flt3/flk2 리간드, B-세포성장인자, B-세포분화인자 및 호산구분화인자, 스틸인자 또는 c-kit 리간드로도 알려진 간세포인자(SCF), 또는 그것의 조합을 포함한다. 상기 투여량은 치료 조성물에서 그러한 부가성분들을 상보하도록 조정될 것이다. 치료받은 환자의 진전은 혈액학적 프로파일, 예컨대 분화세포수 등의 정기적 평가에 의해 모니터할 수 있다.

재료 및 방법

달리 언급하지 않는 한, 모든 특제 화학약품은 Sigma, Co.(St. Louis, MO)로부터 입수하였다. 제한 엔도뉴클레아제 및 T4 DNA 리가제는 New England Biolabs(Beverly, MA) 또는 Boehringer Mannheim(Indianapolis, IN)으로부터 입수하였다.

E. coli 균주의 형질전환

DH5a^tm(Life Technologies, Gaithersburg, MD) 및 TG1(Amersham Corp., Arlington Heights, IL)과 같은 E. coli 균주는 라이게이션 반응물의 형질전환을 위해 사용되고 포유동물 세포를 형질전환시키기 위한 플라스미드 DNA의 공급원이다. JM101(Yanisch-Perron, et al., Gene, 33: 103-119, 1985) 및 MON105(Obukowicz, et al., Appl. and Envir. Micr., 58: 1511-1523, 1992)와 같은 E. coli 균주는 세포질 또는 세포계변공간에서 본 발명의 다기능 키메라 조혈 수용체 아고니스트를 발현시키기 위해 사용될 수 있다.

MON105 ATCC#55204: F-, lambda-, IN(rrnD, rrE)1, rpoD+, rpoH358

DH5a^TM: F-, phi80dlacZdeltaM15, delta(lacZYA-argF)U169, deoR, recA1, endA1, hsdR17(rk-,mk+), phoA, supE44lamda-, thi-1, gyrA96, relA1

TG1: delta(lac-pro), supE, thi-1, hsdD5/F'(traD36, proA+B+, lacIq, lacZdeltaM15)

JM101 ATCC#33876: delta(pro lac), supE, thi, F'(traD36, proA+B+, lacIq, lacZdeltaM15)

DH5a^tm 서브클로닝에 유효한 세포를 콤피턴트 세포로서 구입하고 제조업자의 프로토콜을 사용하여 형질전환시킬 준비를 하는 한편, 양 E. coli 균주 TG1 및 MON105를 콤피턴트 상태가 되도록 하여 CaCl₂법을 사용하여 DNA를 취입한다. 전형적으로, 20 내지 50mL의 세포를, 밀도가 Baush & Lomb 스펙트로닉 분광광도계(Rochester, NY)에 의해 측정될 때 600나노미터(OD600)에서 광학밀도단위로 약 1.0이 되도록 LB 배지(1Bacto-트립톤, 0.5Bacto-효모추출물, 150mM NaCl)에서 성장시킨다. 세포를 원심분리에 의해 수집하고 5/1 배양물 부피의 CaCl₂ 용액(50mM CaCl₂, 10mM Tris-Cl, pH7.4)에 재현탁시키고 4℃에서 30분 동안 유지한다. 세포를 원심분리에 의해 다시 수집하고 5/1 배양물 부피의 CaCl₂ 용액에 재현탁시킨다. 라이게이션된 DNA를 0.2mL의 이들 세포에 가하고 이 샘플을 4℃에서 30-60분 동안 유지한다. 샘플을 2분 동안 42℃로 변화시키고 1.0mL의 LB를 가한 후 샘플을 37℃에서 1시간 동안 진탕한다. 이들 샘플로부터의 세포를, 암피실린 내성 형질전환체를 선택할 때는 암피실린(100마이크로그램/mL, ug/mL)을 함유하고, 스펙티노마이신 내성 형질전환체를 선택할 때는 스펙티노마이신(75ug/mL)을 함유하는 플레이트(LB 배지 및 1.5Bacto-한천)상에 펼친다. 플레이트를 37℃에서 하룻밤 배양한다. 콜로니를 골라내어 적당한 항생물질(100ug/mL의 암피실린 또는 75ug/mL의 스펙트로마이신)을 함유하는 LB 배지에 접종하고 37℃에서 진탕하면서 성장시킨다.

새로운 N-말단/C-말단을 갖는 유전자의 생성방법

방법 I. 링커 영역(L₂)을 함유하는 새로운 N-말단/C-말단을 갖는 유전자의 생성

원래의 C-말단과 N-말단을 분리하는 링커 영역(L₂)을 함유하는 새로운 N-말단/C-말단을 갖는 유전자는 본질적으로 L. S. Mullins 등(J. Am. Chem. Soc. 116, 5529-5533, 1994)에 의해 기재된 방법에 따라 제조될 수 있다. 다단계의 폴리머라제연쇄반응(PCR) 증폭을 사용하여 단백질의 1차 아미노산 서열을 암호화하는 DNA를 재배열한다. 이 단계는 도 2에 예시되어 있다.

제 1 단계에서는, 제 1 프라이머 세트("새로운 스타트" 및 "링커 스타트")를 사용하여, 원래의 유전자 서열로부터, 새로운 단백질의 새로운 N-말단부에 이어서 원래 단백질의 C-말단부와 N-말단부를 연결시키는 링커(L₂)를 암호화하는 서열을 함유하는 DNA 단편("단편 스타트")을 만들어 증폭시킨다. 제 2 단계에서는, 제 2 프라이머 세트("새로운 스톱" 및 "링커 스톱")를 사용하여, 원래의 유전자 서열로부터, 위에서 사용된 것과 동일한 링커에 이어서 새로운 단백질의 새로운 C-말단부를 암호화하는 DNA 단편("단편 스톱")을 만들어 증폭시킨다. "새로운 스타트" 및 "새로운 스톱" 프라이머는 새로운 유전자의 발현 플라스미드내로의 클로닝을 가능하게 하는 적당한 제한부위를 포함하도록 설계한다. 전형적인 PCR 조건은 2분간의 95℃ 용융 1 사이클; 1분간의 94℃ 변성, 1분간의 50℃ 어닐링 및 1분간의 72℃ 연장 25 사이클; 그리고 7분간의 72℃ 연장 1 사이클이다. 퍼킨 엘머 GeneAmp PCR Core Reagents 키트를 사용한다. 100ul의 반응물은 100pmol의 각 프라이머 및 1ug의 주형 DNA; 그리고 1×PCR 완충액, 200uM dGTP, 200uM dATP, 200uM dTTP, 200uM dCTP, 2.5유니트 AmpliTaq DNA 폴리머라제 및 2mM MgCl₂를 함유한다. PCR 반응은 모델 480 DNA 서멀 사이클러(Perkin Elmer Corporation, Norwalk, CT)에서 수행한다.

링커 영역내의 상보적 서열 및 링커 양측의 두 아미노산에 대한 코딩 서열을 갖는 "단편 스타트" 및 "단편 스톱"을 제 3 PCR 단계에서 함께 결합시켜, 새로운 아미노산을 암호화하는 전체길이의 유전자를 제조한다. 이 DNA 단편 "단편 스타트" 및 "단편 스톱"을 1TAE 겔에 용해시키고, 에티디움 브로마이드로 염색하고 Qiaex Gel Extraction 키트(Qiagen)를 사용하여 분리한다. 이들 단편을 등몰량으로 조합하고 70℃에서 10분 동안 가열하고 천천히 냉각시켜, "링커 스타트" 및 "링커 스톱"내의 그들의 공유 서열을 통해 어닐링시킨다. 제 3 PCR 단계에서는, 프라이머 "새로운 스타트" 및 "새로운 스톱"을 어닐링된 단편에 첨가하여 전체길이의 새로운 N-말단/C-말단 유전자를 생성 및 증폭시킨다. 전형적인 PCR 조건은 2분간의 95℃ 용융 1사이클; 1분간의 94℃ 변성, 1분간의 60℃ 어닐링 및 1분간의 72℃ 연장 25 사이클; 그리고 7분간의 72℃ 연장 1 사이클이다. 퍼킨 엘머 GeneAmp PCR Core Reagents 키트를 사용한다. 100ul의 반응물은 100pmol의 각 프라이머 및 약 0.5ug의 DNA; 그리고 1×PCR 완충액, 200uM dGTP, 200uM dATP, 200uM dTTP, 200uM dCTP, 2.5유니트 AmpliTaq DNA 폴리머라제 및 2mM MgCl₂를 함유한다. PCR 반응물은 Wizard PCR Preps 키트(Promega)를 사용하여 정제한다.

방법 II. 링커 영역을 갖지 않는 새로운 N-말단/C-말단을 갖는 유전자의 생성

원래의 N-말단과 C-말단을 결합하는 링커를 갖지 않는 새로운 N-말단/C-말단유전자는 2단계의 PCR 증폭 및 블런트 엔드 라이게이션을 사용하여 제조될 수 있다. 이 단계는 도 3에 예시되어 있다. 제 1 단계에서는, 프라이머 세트("새로운 스타트" 및 "P-bl 스타트")를 사용하여, 원래의 유전자 서열로부터, 새로운 단백질의 새로운 N-말단부를 암호화하는 서열을 함유하는 DNA 단편("단편 스타트")을 생성하여 증폭시킨다. 제 2 단계에서는, 프라이머 세트("새로운 스톱" 및 "P-bl 스톱")를 사용하여, 유전자 서열로부터, 새로운 단백질의 새로운 C-말단부를 암호화하는 서열을 함유하는 DNA 단편("단편 스톱")을 생성하여 증폭시킨다. "새로운 스타트" 및 "새로운 스톱" 프라이머는 새로운 유전자의 발현 벡터내로의 클로닝을 가능하게 하는 적당한 제한부위를 포함하도록 설계한다. 전형적인 PCR 조건은 2분간의 95℃ 용융 1사이클; 1분간의 94℃ 변성, 45초간의 50℃ 어닐링 및 45초간의 72℃ 연장 25 사이클이다. 제조업자가 권장하는 조건에서의 오버행 발생율을 감소시키기 위해 Deep Vent 폴리머라제(New England Biolabs)를 사용한다. "P-bl 스타트" 및 "P-bl 스톱" 프라이머를 5' 말단에서 인산화하여 "단편 스타트" 및 "단편 스톱"의 후속 블런트 엔드 라이게이션"을 돕는다. 100ul의 반응물은 150pmol의 각 프라이머 및 1ug의 주형 DNA; 그리고 1× Vent 완충액(New England Biolabs), 300uM dGTP, 300uM dATP, 300uM dTTP, 300uM dCTP, 1유니트 Deep Vent 폴리머라제를 함유한다. PCR 반응은 모델 480 DNA 서멀 사이클러(Perkin Elmer Corporation, Norwalk, CT)에서 수행한다. PCR 반응생성물은 Wizard PCR Preps 키트(Promega)를 사용하여 정제한다.

프라이머는 새로운 유전자의 발현 벡터내로의 클로닝을 가능하게 하는 적당한 제한 부위를 포함하도록 설계한다. 전형적으로 "단편 스타트"는 NcoI 제한부위를 생성하도록 설계하고, "단편 스톱"은 HindIII 제한부위를 생성하도록 설계한다. 제한분해반응물은 Magic DNA Clean-up System 키트(Promega)를 사용하여 정제한다. 단편 스타트 및 스톱을 1TAE 겔에 용해시키고 에티디움 브로마이드로 염색하고 Qiaex Gel Extraction 키트(Qiagen)를 사용하여 분리한다. 이들 단편을 등몰량으로 조합하고 50℃에서 10분 동안 가열함으로써 pMON3934의 ~3800 염기쌍 NcoI/HindIII 벡터 단편의 말단들을 어닐링하고 천천히 냉각시킨다. 세개의 단편을 T4 DNA 리가제(Boehringer Mannheim)를 사용하여 함께 어닐링시킨다. 그 산물은 전체길이의 새로운 N-말단/C-말단 유전자를 함유하는 플라스미드이다. 이 라이게이션 반응물의 일부를 사용하여 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환시킨다. 플라스미드 DNA를 정제하고 서열을 이하와 같이 확인한다.

방법 III. 탠덤 중복 방법에 의한 신규의 N-말단/C-말단 유전자의 생성

신규의 N-말단/C-말단 유전자를 R.A. Horlick, et al Protein Eng. 5:427-431,1992에 기술된 방법에 기초하여 만들 수 있다. 신규의 N-말단/C-말단 유전자의 폴리머라제 연쇄반응(PCR) 증폭은 탠덤식으로 중복 된 주형 DNA를 이용하여 수행한다. 이 단계를 도 3에 도시한다.

탠덤식으로 중복된 주형 DNA를 클로닝에 의하여 생성되고 2개의 유전자 카피의 원래의 C- 및 N-말단을 연결하는 링커를 함호화하는 DNA 서열에 의해 분리된 2개의 유전자카피를 포함한다. 특정한 프라이머 세트를 이용하여 탠덤식으로 중복된 주형 DNA로부터 전체길이의 신규의 N-말단/C-말단 유전자를 생성하고 증폭시킨다. 이 프라이머들은 새로운 유전자의 발현벡터내로의 클로닝을 허용하는 적절한 제한부위를 포함하도록 설계한다. 전형적인 PCR조건은 2분간의 95℃ 용융 1사이클; 1분간의 94℃ 변성, 1분간의 50℃ 어닐링 및 1분간의 72℃ 연장 25 사이클; 그리고 7분간의 72℃ 연장 1 사이클이다. Perkin Elmer GeneAmp PCR Core Reagents 키트(Perkin Elmer Corporation, Norwalk, CT)를 이용하였다. 100ul 반응물은 각 프라이머 100pmol 및 주형 DNA 1ug; 그리고 1xPCR 완충액, 200uM dGTP, 200uM dATP, 200uM dTTP, 200uM dCTP, 2.5단위 AmpliTaq DNA 폴리머라제 및 2mM MgCl₂를 포함한다. PCR 반응은 모델 480 DNA 서멀 사이클러(Perkin Elmer Corporation, Norwalk, CT)에서 수행한다. PCR 반응물은 Wizard PCR Preps kit(Promega)를 이용하여 정제한다.

다기능 수용체 아고니스트 발현벡터내의로 새로운 N-말단/C-말단 유전자의 클로닝

새로운 N-말단/C-말단 유전자를 제한 엔도뉴클레아제로 분해하여 다른 콜로니자극인자 유전자를 포함하는 발현벡터내로의 삽입에 적합한 말단을 생성한다. 이 발현벡터는 마찬가지로 제한 엔도뉴클레아제로 분해하여 적합한 말단을 형성한다. 정제후에, 유전자와 벡터DNA를 조합하고 T4 DNA 리가제를 이용하여 라이게이션시킨다. 일련의 라이게이션반응물의 일부를 이용해서 E. coli를 형질전환시킨다. 플라스미드 DNA를 정제하고 서열화하여 올바른 삽입을 확인한다. 올바른 클론을 단백질 발현을 위하여 성장시켰다.

DNA 분리 및 특성화

플라스미드 DNA는 다수의 다양한 방법에 의하여 당업자에게 공지된 시판되는 키트를 이용하여 분리할 수 있다. 그런 몇가지 방법들을 여기에 나타낸다. 플라스미드 DNA를 Promega Wizard^TM Miniprep 키트(Madison, WI), Qiagen QIAwell Plasmid 분리 키트(Chatsworth, CA) 또는 Qiagen Plasmid Midi 키트를 이용하여 분리한다. 이 키트는 플라스미드 DNA분리에 대한 동일한 일반적 방법을 따른다. 요약하면, 세포를 원심분리(5000×g)에 의하여 펠렛화하고, 방출된 플라스미드 DNA를 연속해서 NaOH/산으로 처리하고, 세포잔해물을 원심분리에 의해 제거한다(10000×g). 상청액(플라스미드 DNA를 포함)을 DNA-결합 수지를 포함한 칼럼에 충전하고, 칼럼을 세척하고 플라스미드 DNA를 TE로 용리한다. 관심플라스미드를 갖는 콜로니에 대해 스크리닝한후에 E. coli 세포를 50-100mL의 LB 더하기 적절한 항생제내로 접종시켜서 37℃에서 공기 배양기내에서 진탕하면서 밤새워 성장시킨다. 정제한 플라스미드 DNA를 DNA 서열화, 추가의 제한효소 분해, DNA 단편의 추가적 서브클로닝 및 포유동물, E. coli 또는 다른 세포로의 트랜스펙션을 위해 이용한다.

서열 확인

정제한 플라스미드 DNA를 dH₂O에 재현탁시키고, Bausch and Lomb Spectronic 601 UV 분광계에서 260/280nm에서의 흡광도를 측정함으로서 정량한다. DNA 샘플을 서열화 혼합물에 5DMSO를 첨가하여 보통 수정된 제조업자가 제안한 프로토콜에 따라 ABI PRISM^TM DyeDeoxy^TM 터미네이터 서열화 케미스트리(Applied Biosystems Division of Perkin Elmer Corporation, Lincoln City, CA) 키트(Part Number 401388 또는 402078)를 이용해서 서열화한다. 서열화반응은 추천된 증폭 조건에 따라 모델480 DNA 서멀 사이클러(Perkin Elmer Coporation, Norwalk, CT)내에서 수행한다. 샘플을 정제하여 Centri-Sep^TM 스핀 칼럼(Princeton Separations, Adelphia, NJ)으로 과잉의 염색 터미네이터를 제거하고 동결건조한다. 형광염료로 표지된 서열화반응물을 탈이온된 포름아미드중에 재현탁시키고, ABI Model 373A 자동 DNA 시퀀서를 이용하여 변성 4.75폴리아크릴아미드-8M 요소겔상에서 서열화한다. Sequencer DNA 분석 소프트웨어(Gene Codes Corporation, Ann Arbor, MI)를 이용하여 중복되는 DNA 서열 단편을 분석하고 마스터 DNA 콘티그로 조립한다.

포유동물세포에서 다기능 수용체 아고니스트의 발현

조건 배지의 포유동물 세포 트랜스펙션/생산

BHK-21 세포계는 ATCC(Rockville, MD)로부터 얻을수 있다. 이 세포를 2mM(mM) L-글루타민 및 10우태아 혈청(FBS)으로 보충한 Dulbecco의 변형된 Eagle 배지(DMEM/고농도 글루코스)에서 배양한다. 이 제제는 BHK 성장배지로 일컬어진다. 선택적 배지는 453단위/mL 하이그로마이신 B(Calbiochem, San Diego, CA)로 보충된 BHK 성장배지이다. BHK-21세포계를 단백질 VP16을 트랜스활성화시키는 HSV로 미리 안정하게 트랜스펙션시켰고, 이것은 플라스미드 pMON3359상에서 발견되는 IE110 프로모터를 트랜스활성화시킨다(Hippenmeyer et al., Bio/Technology, pp.1037-1041, 1993참조). VP16단백질은 IE110프로모터로 삽입된 유전자의 발현을 촉진한다. 트랜스활성 단백질 VP16을 발현하는 BHK-21 세포는 BHK-VP16으로 일컬어진다. 플라스미드 pMON1118(Highkin et al., Poultry Sci., 70: 970-981, 1991 참조)는 SV40프로모터로부터 하이그로바이신 내성 유전자를 발현한다. 유사한 플라스미드가 ATCC, pSV2-hph로부터 이용가능하다.

BHK-VP16세포를 트랜스펙션하기 24시간전에 접시당 3×10⁵세포를 갖는 60밀리미터(mm) 조직배양접시로 뿌렸다. 세포를 16시간동안 관심유전자를 포함하는 10ug 플라스미드 DNA, 3ug 하이그로마이신 내성플라스미드, pMON1118, 및 80ug Gibco-BRL "LIPOFECTAMINE"^TM을 포함하는 3mL "OPTOMEM"^TM(Gibco-BRL, Gaithersburg, MD)내에서 트랜스펙션시킨다. 이어서 배지를 흡입하고 3mL 성장배지로 교체한다. 트랜스펙션한지 48시간후에 각접시의 배지를 수집하여 활성을 분석한다(일시적 조건배지). 세포를 트립신-EDTA에 의하여 접시에서 제거하고, 1:10으로 희석하여 10 mL의 선택적 배지를 포함하는 100mm 조직배양접시로 옮긴다. 선택적 배지에서 7일이 지난후, 내성을 갖는 세포가 수 밀리미터 지름을 갖는 콜로니로 성장한다. 콜로니를 여지(콜로니와 동일한 크기로 잘라서 트립신/EDTA에 담금)로 접시에서 제거하고 1 mL 선택적 배지를 포함한 24 웰 플레이트의 각각의 웰로 옮긴다. 콜로니가 집합으로 성장한후 조절된 배지를 재분석하고, 양성 클론을 성장배지에 펼친다.

E. coli 내에서 다기능 수용체 아고니스트의 발현

관심플라스미드를 품는 E. coli 균주 MON105 또는 JM101을 New Brunswick Scientific(Edison, New Jersey)의 모델G25 공기 배양기내에서 흔들면서 M9 더하기 카사미노산 배지에서 37℃에서 성장시킨다. 성장은 OD600에서 이것이 1.0의 값에 도달한 시간까지 추적하고, 이때 0.1N NaOH중 날리딕스 산(10 mg/mL)을 최종농도 50㎍/mL로 가하였다. 그후 배양물을 추가의 3 내지 4시간동안 37℃에서 흔든다. 요구되는 유전자 제품의 최대생산을 얻기 위하여 배양기간 내내 고도의 공기주입을 유지한다. 봉입체(IB)의 존재에 대하여 광학현미경으로 세포를 검사한다. 단백질함량분석을 위하여 배양물을 1mL 씩 세포펠렛을 끊여서 제거하고, 이것을 환원완충액로 처리하고, SDS-PAGE를 통하여 전기영동한다(Maniatis et al. Molecular Cloning: A Laboratory Manual, 1982참조). 배양물을 원심분리(5000×g)하여 세포를 펠렛화한다.

봉입체제조, 추출, 재폴딩, 투석, DEAE 크로마토그래피, 및 E. coli 에서 포합체로 축적되는 다기능 키메라 조혈수용체 아고니스트의 확인

봉입체의 단리:

330 mL E. coli 배양으로부터 세포펠렛을 15mL 초음파 완충액(10 mM 2-아미노-2-(하이드록시메틸) 1,3-프로판디올 염산염(Tris-HCl), pH 8.0 + 1 mM 에틸렌디아민테트라아세트산(EDTA))내에서 재현탁한다. 재현탁된 세포를 Sonicator Cell Disruptor(Model W-375, Heat Systems-Ultrasonics, Inc., Farmingdale, New York)의 미세탐침을 이용해서 초음파분해한다. 초음파완충액에서 세차례의 초음파분해 뒤 원심분리를 사용해서 세포를 붕괴시키고 봉입체(IB)를 세척한다. 첫 번째 초음파분해는 3분간, 이어서 1 분간 행하고, 최종 2차례의 초음파분해는 각각 1분씩 행한다.

봉입체 펠렛으로부터 단백질의 추출 및 재폴딩:

최종 원심분리 단계에 이어서, IB펠렛을 10mL의 50mM Tris-HCl, pH9.5, 8M 요소 및 5mM 디티오트레이톨(DTT)중에 재현탁시키고 발현된 단백질의 변성이 일어나도록 약 45분간 실온에서 교반한다.

추출 용액을 5mM Tris-HCl, pH9.5 및 2.3M 요소의 70mL을 포함하는 비이커로 옮기고, 단백질이 재폴딩하도록 4℃에서 18 내지 48시간동안 공기에 노출시켜 살살 교반한다. 재폴딩을 Vydac(Hesperia, Ca.) C18 역상 고압 액체 크로마토그래피(RP-HPLC) 칼럼(0.46×25cm)상에서 분석에 의하여 추적한다. 0.1삼불소화아세트산(TFA)를 포함하는 40내지 65의 선형구배를 사용하여 재폴딩을 추적하였다. 이 구배는 분당 1.5mL의 유속으로 30분에 걸쳐 전개된다. 변성된 단백질은 일반적으로 재폴딩된 단백질보다 늦게 용리된다.

정제:

재폴딩후에 오염된 E. coli 단백질을 산침전에 의하여 제거한다. 재폴딩용액의 pH를 15(v/v) 아세트산(HOAc)을 이용하여 pH 5.0 과 pH 5.2사이로 적정한다. 이 용액을 4℃에서 2시간 동안 저은후 12,000×g에서 20분간 원심분리하여 불용성 단백질을 펠렛화한다.

산침전단계로부터의 상청액을 3,500달톤 분자량 컷어프(MWCO)를 갖는 Spectra/Por 3 막을 이용하여 투석한다. 투석을 총 18시간동안 pH8.0의 10 mM Tris-HCl 4리터(50배 과잉)에 대하여 2번 바꾸어 행한다. 투석은 샘플의 전도성을 낮추고 DEAE 크로마토그래피를 하기에 앞서 요소를 제거한다. 그런다음 샘플을 원심분리(12,000×g에서 20분간)하여 투석에 따르는 불용성 단백질을 펠렛화 하였다.

Bio-Rad Bio-Scale DEAE2 칼럼(7×52mm)을 이온 교환 크로마토그래피에 이용한다. 칼럼을 10mM Tris-HCl, pH8.0, 및 0 내지 500mM 염화나트륨(NaCl) 구배를 포함하는 완충액내에서 평형을 유지시키고, 평형완충액내에서 45칼럼부피에 걸쳐 단백질을 용리하기 위하여 이용한다. 분당 1.0 mL의 유속이 전개를 통해서 이용된다. 칼럼분획(분획당 2.0 mL)을 구배를 가로질러 수집하고 Vydac(Hesperia, Ca.) C18칼럼(0.46×25cm)상에서 RP HPLC에 의해 분석한다. 0.1삼불소화아세트산(TFA)을 포함하는 40내지 65아세토니트릴의 선형구배를 사용한다. 이 구배를 분당 1.5mL의 유속으로 30분에 걸쳐 전개시킨다. 고인 분획을 그후 10mM 암모니아 아세테이트(NH₄Ac), pH 4.0 4리터(50 내지 500배 과잉)에 대하여 2번 바꾸어 전부 18시간동안 투석하였다. 3,500달톤의 MWCO를 갖는 Spectra/Por 3 막을 이용해서 투석을 수행한다. 마지막으로 0.22㎛ 주사기 필터(μStar LB syringe filter, Costar, Cambridge, Ma.)를 이용하여 무균 여과하고, 4℃에서 저장한다.

몇몇 경우에 폴딩된 단백질은 적절한 기제에 부착된 mAbs 또는 수용체 서브유니트 같은 친화성 시약을 이용하여 정제된 친화성일수 있다. 선택적으로(또는 추가하여), 이온 교환, 겔 여과 또는 소수성 크로마토그래피 또는 역상HPLC 같은 다양한 크로마토그래피 방법을 이용하여 정제할수도 있다.

이것 및 다른 단백질 정제방법은 Murray Deutscher, Academic Press, San Diego, CA(1990)에 의해 편집된 Methods in Enzymology, Volume 182 '단백질 정제 가이드'에 상세히 기술되어 있다.

단백질 특성화:

정제된 단백질을 RP-HPLC, 전기분사량 분광계, 및 SDS-PAGE에 의해 분석하였다. 단백질 정성은 아미노산 조성, RP-HPLC, 및 브래드포드 단백질 결정에 의하여 행한다. 몇몇 경우에는 단백질의 정체를 확인하기 위하여 전기분사량 분광계와 함께 트립신 펩티드 매핑을 수행한다.

생물활성의 사람 인터루킨-3에 대한 AML 증식 분석

인자-의존성 세포계 AML193을 American Type Culture Collection(ATCC, Rockville, MD)로부터 얻었다. 급성 골수성 백혈병환자로부터 확립된 이 세포계는 GM-CSF로 보충된 배지에서 증가된 성장을 보이는 성장인자 의존성 세포계이다(Lange, B et al., Blood 70: 192, 1987; Valtieri, M et al., J. Immunol. 138:4042, 1987). 사람 IL-3존재하에서 AML 193세포의 증식하는 능력도 또한 기록되있다(Santoli, D. et al., J. Immunol. 139: 348, 1987). 성장인자를 세척하고 성장 인자에 대한 시토킨 의존성 AML193 세포를 24시간동안 굶겨서 IL-3내에서 장기간 성장에 적합한 세포계 변종인 AML 193 1.3을 이용하였다. 그후 세포를 100U/mL IL-3을 포함한 배지중 24 웰 플레이트에 1×10⁵ 세포/웰로 재배치하였다. 세포가 IL-3중에서 빨리 성장하는데는 대략 2달정도 소요된다. 이 세포를 사람 IL-3와 함께 조직 배양배지를 보충하여 그후로 AML 193 1.3으로 유지하였다.

AML 193 1.3세포를 냉 Hanks 평형염용액(HBSS, Gibco, Grand Island, NY)에서 세포현탁액을 250×g에서 10분간 원심분리에 의하여 6회 세척한후 상청액을 천천히 부었다. 세포펠렛을 HBSS내에서 재현탁시키고 6회의 세척사이클이 완료될때까지 위 순서를 반복하였다. 이 순서에 따라 6회 세척된 세포를 2×10⁵ 내지 5×10⁵ 생존가능한 세포/mL 범위의 밀도에서 조직배양배지중에 재 현탁시켰다. 이 배지는 Iscove의 수정된 Dulbecco 배지(IMDM, Hazelton, Lenexa, KS)를 알부민, 트랜스페린, 지질 및 2-메르캅토에탄올로 보충시켜서 제조한다. 소 알부민(Boehringer-Mannheim, Indianapolis, IN)을 500㎍/mL로 가했다; 사람 트랜스페린(Boehringer-Mannheim, Indianapolis, IN)을 100㎍/mL로 가했다; 콩 지질 (Boehringer-Mannheim, Indianapolis, IN)을 50㎍/mL로 가했다; 및 2-메르캅토에탄올(Sigma, St. Louis, MO)를 5×10^-5M로 가하였다.

사람 인터루킨-3 또는 다기능 키메라 조혈 수용체 아고니스트의 일련의 희석액들을 96웰 Costar 3596 조직배양 플레이트에서 위 기재대로 보충된 조직배양 배지중 3개씩 만들었다. 인터루킨-3 또는 다기능 키메라 조혈 수용체 아고니스트 단백질을 포함하는 배지의 50㎕가 포함된 각각의 웰을 완성하였다. 대조웰은 조직배양배지 단독만을 포함한다(음성 대조). 상기한 대로 제조된 AML 193 1.3 세포 현탁액을 각 웰내로 50㎕(2.5×10⁴ 세포)씩 피펫으로 각 웰마다 가하였다. 조직 배양 플레이트를 3일간 가습 공기에서 5CO₂와 함께 37℃에서 배양하였다. 셋째날에 0.5 μCi ³H-티미딘(2 Ci/mM, New England Nuclear, Boston, MA)를 50㎕ 조직배양배지에 가하였다. 배양물을 18-24시간동안 가습된공기에서 5CO₂와 함께 37℃에서 배양하였다. 세포 DNA를 물 세척 사이클에 이어 70에탄올 세척 사이클을 이용하는 TOMTEC 세포 수거기(TOMTEC, Orange, CT)를 이용하여 유리여과매트(Pharmacia LKB, Gaithersburg, MD)로 수거하였다. 여과기 매트는 공기 건조할수 있고, 섬광유액(Scintiverse II, Fisher Scientific, St. Louis, MO 또는 BetaPlate Scintillation Fluid, Pharmacia LKB, Gaithersburg, MD)을 가하는 샘플 백에 놓을 수도 있다. 각 조직배양 웰로부터 샘플의 베타 방사를 LKB BetaPlate 모델 1205 섬광 계수기(Pharmacia LKB, Gaithersburg, MD)로 카운트하였고 데이터를 각 조직배양 웰에서 세포로 혼입된 ³H-티미딘의 분당 카운트로 표시하였다. 각 사람 인터루킨-3 제제 또는 다기능 키메라 조혈 수용체 아고니스트 단백질 제제의 활성을 인터루킨-3 또는 다기능 키메라 조혈 수용체 아고니스트의 농도에 의하여 유도된 세포증식(³H-티미딘 혼입)을 측정함으로써 정량하였다. 전형적으로, 0.05 pM-10⁵ pM의 농도범위가 이 분석에서 정량된다. 활성은 최대 증식의 50(EC₅₀=0.5x(인터루킨-3을 결핍한 3개의 배양에서 관찰된 ³H-티미딘 혼입에 의해 측정된 배경증식이 시험된 인터루킨-3의 모든농도의 3개 배양중에서 웰당 혼입된 ³H-티미딘의 분당 최대 평균 개수)를 제공하는 인터루킨-3 또는 다기능 키메라 조혈 수용체 아고니스트 단백질의 용량을 측정함으로써 결정하였다. 이 EC₅₀값은 또한 1단위의 생물활성과 대응한다. 모든 분석을 상대적 활성 수준을 평가할수 있도록 참고기준으로써 천연 인터루킨-3와 함께 수행하였다.

전형적으로, 다기능 키메라 조혈 수용체아고니스트 단백질을 일련의 2배 희석에서 적정된 2000 pM 내지 0.06pM의 농도범위에서 시험하였다.

각 샘플에 대한 활성을 4개의 변수 논리 모델을 데이터에 맞춤으로써 최대 반응의 50를 주는 농도에 의하여 결정하였다. 샘플 및 이것과 비교된 표준에 대한 상부 평탄역이 다르지 않음을 관찰하였다. 그러므로 각 샘플에 대한 상대적 효능 계산을 위에서 지시된 대로 샘플 및 표준에 대하여 EC₅₀평가로부터 결정하였다. AML 193.1.3세포는 hIL-3, hGM-CSF 및 hG-CSF와 반응하며 증식하였다. 그러므로 이하의 추가적 분석을 다기능 키메라 조혈 수용체 아고니스트 단백질의 G-CSF 수용체 아고니스트 부위가 활성이 있는지를 증명하기 위하여 몇몇 샘플에 대하여 수행하였다. 증식 분석을 다기능 키메라 조혈 수용체 아고니스트 더하기 및 빼기 hIL-3 수용체 아고니스트 부위에 대한 중화성 모노클로날 항체와 함께 수행하였다. 부가하여, 절단부위 Xa인자를 갖는 융합 분자를 잘라서 정제한 뒤, 분자의 절반을 증식활성에 대하여 분석하였다. 이 실험은 다기능 키메라 조혈 수용체 아고니스트 단백질의 양 성분이 활성이라는 것을 보인다.

TF1 c-mpl 리간드 의존성 증식 분석

c-mpl 리간드 증식 활성을 다효능 사람 세포계 TF1의 서브클론을 이용해서 분석하였다(Kitamura et al., J. Cell Physiol 140:323-334. [1989]). TF1 세포를 h-IL3(100 u/mL)내에서 유지하였다. c-mpl 리간드에 반응하는 서브클론임을 확인하기 위해, 세포를 c-mpl 리간드의 1-153형태를 발현하는 유전자(pMON26448)로 트랜스펙션시킨 BHK세포로부터의 10상청액을 포함하는 통로배지에서 유지하였다. 대부분의 세포가 죽었으나, 일말의 세포는 생존하였다. 희석 클로닝 후에, c-mpl 리간드 반응성 클론을 선택하고, 이 세포를 분석시작하기 전날 0.3×10⁶세포/mL의 밀도로 통로배지로 분배하였다. 이 세포에 대한 통로배지는 다음과 같다: RPMI 1640(Gibco), 10FBS(Harlan, Lot #91206), BHK세포로 트랜스펙션된 10c-mpl 리간드 상청액, 1mM 소디움 피루베이트(Gibco), 2mM 글루타민(Gibco), 및 100ug/mL 페니실린-스트렙토마이신(Gibco). 다음날, 세포를 수거하고 RPMI 또는 IMDM 배지에서 2회 세척하고 최종세척은 ATL 또는 분석배지에서 행하였다. ATL 배지는 다음으로 구성된다: IMDM(Gibco), 500 ug/mL 소혈청 알부민, 100 ug/mL 사람 트랜스페린, 50ug/mL 콩지질, 4×10^-8M 베타-메르캅토에탄올 및 1000mL ATL당 2mL A9909(Sigma, 항생용액). 세포를 분석 배지에서 희석하여 최종부피 50 ul에 대해 96-웰 저증발 플레이트(Costar)중 0.25×10⁶ 세포/mL의 최종밀도로 하였다. 트랜스펙션된 클론으로부터 일시적 상청액(조건 배지)을 50 ul의 용적으로 2개의 샘플에 가하여 50의 최종농도로 하고, 3배 희석하여 1.8의 최종 희석액이 되게 하였다. 1 ng/mL에서 시작하여 3배 희석액을 이용하여 0.0014 ng/mL까지 희석된 IL-3 변이체 pMON13288의 용량곡선의 3개의 샘플이 양성대조로써 포함되었다. 플레이트를 5CO₂, 37℃에서 배양하였다. 배양 6일에, 플레이트를 20 ul/웰의 용적중 3H/웰(NEW)의 0.5 Ci로 자극하였고, 4시간동안 5CO₂, 37℃에서 배양하였다. 플레이트를 수거하고 Betaplate 계수기로 카운트하였다.

MUTZ-2 세포 증식 분석

사람 골수성 백혈병 세포계인 MUTZ-2같은 세포계(German Collection of Microorganisms and Cell Cultures, DSM ACC 271)를 flt3 수용체 아고니스트의 세포증식활성을 결정하기 위하여 이용할수 있다. MUTZ-2배양을 성장배지에서 재조합 순수 flt3 리간드(20-100ng/mL)와 함께 유지하였다. 분석시작 18시간 전에 MUTZ-2세포를 IMDM배지(Gibco)에서 3회 세척하고 0.5 내지 0.7x10E6 세포/mL의 농도로 IMDM 단독배지중 재현탁하고, 37℃ 및 5CO₂에서 flt3 리간드를 굶기기 위해 배양하였다. 분석 당일날, 표준 및 flt3수용체 아고니스트를 두배로 희석하여 멸균 조직 배양처리된 96 웰 플레이트에서 분석배지중 상기 요구되는 최종농도로 하였다. Flt3 수용체 아고니스트 및 표준을 각 3개로 시험하였다. 50㎕분석 배지를 A열을 제외한 모든 열에 충전시켰다. 75㎕ flt3 수용체 아고니스트 또는 표준을 A열에 가하였고 이열 및 나머지 플레이트(B 내지 G열)상에서 수행한 일련의 희석액(1:3)에서 25㎕를 취하였다. H열은 대조로써 배지 단독으로 남겼다. 굶긴 MUTZ-2세포를 IMDM 배지에서 2회 세척하고, 50㎕ 분석 배지에서 재현탁시켰다. 50㎕ 세포를 각 웰에 가해서 최종농도 0.25×10E6 세포/mL로 하였다. 세포를 포함한 분석 플레이트를 44시간동안 5CO₂ 및 37℃에서 배양하였다. 각 웰을 4시간동안 20㎕ 용적중의 적정된 티미딘의 1μCi/웰로 자극하였다. 그리고나서 플레이트를 수거하고 카운트하였다.

기타 생체외 세포에 기초한 증식 분석

당업자에게 공지된 생체외 다른 세포에 기초한 분석도 AML 193.1.3 세포 증식 분석에 기술된 것과 동일한 방식의 분자를 포함하는 인자에 의존하는 다기능 키메라 조혈 수용체 아고니스트의 활성을 결정하기 위하여 또한 유용할 수 있다. 다음은 기타 유용한 분석의 예이다.

TF1 증식 분석: TF1은 hIL-3에 반응하는 다능성 사람 세포계이다(Kitamura et al., J. Cell Physiol 140:323-334. [1989]).

32D 증식 분석: 32D는 사람 IL-3에는 반응하지 않으나 종이 제한되지 않은 사람 G-CSF와 반응하는 쥐의 IL-3 의존성 세포계이다.

Baf/3 증식 분석: Baf/3는 사람 IL-3 또는 사람 c-mpl 리간드에는 반응하지 않으나 종이 제한되지 않은 사람 G-CSF와 반응하는 쥐의 IL-3 의존성 세포계이다.

T1165 증식 분석: T1165세포는 IL-6 및 IL-11과 반응하는 IL-6의존성 쥐의 세포계(Nordan et al., 1986)이다.

사람 혈장 응고 meg-CSF 분석: 거핵구 콜로니 형성 활성을 분석하는데 이용된다(Mazur et al.,1981).

트랜스펙션된 세포계:

쥐의 Baf/3 세포계같은 세포계는 사람 G-CSF 수용체 또는 사람 c-mpl 수용체등과 같은 세포계가 갖지 못한 콜로니자극인자 수용체로 트랜스펙션시킬수 있다. 이 트랜스펙션된 세포계를 세포계로 트랜스펙션된 수용체에 대한 리간드의 활성을 결정하기 위하여 이용할수 있다.

그런 트랜스펙션된 Baf/3 세포계 하나를 c-mpl 반응성 세포계에서 만들어진 라이브러리로부터 c-mpl을 코드화하고 플라스미드 pcDNA3(Invitrogen, San Diego Ca.)의 복수 클론부위에 클론된 cDNA를 클로닝함으로써 만들었다. Baf/3세포를 일렉트로포레이션을 통해서 플라스미드로 트랜스펙션시켰다. 세포를 Wehi 조건 배지에서 마우스 IL-3의 존재중 G418 선택하에서 성장시켰다. 제한 희석을 통하여 클론을 안정화시켰다.

유사한 방법으로 사람 G-CSF 수용체를 Baf/3 세포계로 트랜스펙션시킬수 있고 다기능 키메라 조혈 수용체 아고니스트의 생활성을 결정하는데 이용할수 있다.

c-mpl 리간드 증식활성의 분석

방법

1. 골수증식 분석

2. CD34+ 세포 정제:

골수 흡입물을(15-20mL) 정상 동종이계 골수 기증자로부터 사전 동의 후에 얻었다. 세포를 인산염 완충액 염수(PBS, Gibco-BRL)에서 1:3으로 희석하였고, 30mL를 15mL Histopaque-1077(Sigma)에서 층으로 하였고, 300 RCF에서 30분간 원심분리하였다. 단핵 경계면층은 수집하여 PBS에서 세척하였다. CD34+ 세포를 제조자 설명서에 따라 친화성 칼럼을 이용해서 단핵세포제제로부터 풍부하게 얻었다(CellPro, Inc., Bothell WA). 풍부하게 얻은 후에, CD34+ 세포의 순도는 플루오레세인과 결합된 항-CD34 모노클로날 항체 및 피코에리트린(Becton Dickinson, San Jose CA)과 결합된 항-CD38을 이용한 유동 세포계산분석에 의하여 결정하여 평균 70였다.

세포를 X-Vivo 10배지(Bio-Whittaker, Walkersviller, MD)중에 40,000 세포/mL로 재현탁시키고 12-웰 조직배양 플레이트(Costar)중에서 1mL를 깔았다. 성장인자 rhIL-3을 100ng/mL(pMON5873)으로 몇몇 웰에 가하였다. hIL3 변종을 10 ng/mL 내지 100ng/mL로 이용하였다. c-mpl 리간드 또는 다기능 키메라 조혈수용체 아고니스트를 코드화하는 플라스미드로 트랜스펙션된 BHK 세포에서 조건배지를 1mL 배양(대략 10희석)에 가해진 상청액 100㎕의 부가에 의하여 시험하였다. 세포를 37℃ 가습된 배양기에서 8-14일간 5CO₂, 37℃에서 배양하였다.

b. 세포 수거와 분석:

배양기간의 끝에서, 총세포카운트를 각 조건에 대하여 얻었다. 형광 분석 및 배수성 결정을 위하여, 세포를 항-CD41a FITC 항체(1:200, AMAC, Westbrook, ME)를 포함하는 MK 완충액의 500㎕중에 재현탁된 거핵구완충액(MK 완충액, 13.6mM 소디움 시트레이트, 1mM 테오필린, 2.2 ㎛ PGE1, 11 mM 글루코스, 3w/v BSA, PBS중, pH 7.4)(Tomer et al., Blood 70: 1735-1742, 1987)에서 세척하고 MK완충액 500㎕에서 세척하였다. DNA 분석을 위하여, 세포를 0.5Tween 20(Fisher, Fair Lawn NJ)를 포함한 MK 완충액내에서 얼음상에서 20분간 투과성으로 만든후 0.5Tween 20 및 1파라포름알데히드(Fisher Chemical)내에서 30분간 고정시킨후 55v/v MK 완충액(200mOsm)내에서 1-2시간동안 얼음상에서 RNAase(400 U/mL)와 함께 프로피듐 요오드(Calbiochem, La Jolla Ca)(50㎍/mL)내에서 인큐베이션하였다. 세포를 FACScan 또는 Vantage 유동 세포계산기(Becton Dickinson, San Jose, CA)상에서 분석하였다. 초록빛의 형광(CD41a-FITC)을 DNA배수성을 결정하기 위하여 붉은 형광(PI)에 대한 선형의 로그신호에 따라 수집하였다. CD41+인 세포의 퍼센트를 결정하기 위하여 모든세포를 수집하였다. 데이터분석은 LYSIS에 의한 소프트웨어를 이용하여 수행하였다(Becton Dickinson, San Jose, CA). CD41 항원을 발현하는 세포의 퍼센트를 유동 세포계산 분석(퍼센트)으로부터 얻었다. CD41+ 세포/mL의 절대치(Abs)는 (Abs)=(세포 개수)^*(퍼센트)/100 에 의하여 계산하였다.

2. 거핵구 섬유소 응고 분석.

CD34+가 풍부한 집단을 상기한대로 단리하였다. 세포를 0.3BSA, 0.4mg/mL 아포-트랜스페린, 6.67μM FeCl₂, 25㎍/mL CaCl₂, 25㎍/mL L-아스파라긴, 500㎍/mL e-아미노-n-카프로익 산 및 페니실린/스트렙토마이신으로 보충된 기본 Iscoves IMDM 배지로 구성되는 배지중 시토킨과 함께 또는 없이 25,000 세포/mL로 현탁하였다. 35mm로 깔기전에 트롬빈을 가하여(0.25 단위/mL) 응고 형성을 초기화하였다. 세포를 37℃ 가습 배양기내에서 13일간 37℃ 5CO₂에서 배양하였다.

배양기간의 끝에 플레이트를 메탄올:아세톤(1:3)으로 고정시키고, 공기건조하고 염색때까지 -200℃에서 저장하였다. 항-CD41a, CD42 및 CD61로 구성된 1차 모노클로날 항체의 칵테일을 이용하여 퍼록시다제 면역세포화학염색방법을 이용하였다(Zymed, Histostain-SP. San Francisco, CA). 염색후 콜로니를 카운트하고 음성, CFU-MK(소콜로니, 1-2 초점 및 대략 25세포 이하), BFU-MK(25세포초과를 갖는 대, 다초점 콜로니) 또는 혼합콜로니(양성 및 음성세포 둘다의 혼합물)로 분류하였다.

메틸셀룰로오스 분석

이 분석은 체외에서 정상골수 세포를 자극하여 여러 형태의 조혈 콜로니를 생산하도록 하는 콜로니자극인자의 능력을 반영한 것이다(Bradley at el., Aust. Exp Biol. Sci. 44:287-300, 1966, Pluznik et al., J. Cell Comp. Physio 66:319-324, 1965).

방법

신선한, 정상의, 건강한 골수 흡입물의 대략 30mL을 사전 동의하에 각 개체로부터 얻었다. 무균 조건하에서 샘플을 50mL 코니칼 튜브(#25339-50 Corning, Corning MD)중 1X PBS(#14040.059 Life Technologies, Gaithersburg, MD.) 용액으로 1:5로 희석하였다. 피콜(Ficoll;Histopaque 1077 Sigma H-8889)을 희석된 샘플밑에 층으로 깔았고, 30분간 300×g로 원심분리 하였다. 단핵세포밴드를 제거하고, 1XPBS에서 2회 세척하고 1BSA PBS(CellPro Co., Bothel, WA)로 한번 더 세척하였다. 단핵세포를 카운트하였고 CD34+ 세포를 Ceprate LC(CD34) 키트 (Cellpro Co., Bothel, WA) 칼럼을 이용하여 선택하였다. 이 분류는 골수 내의 모든 어미 및 간세포는 CD34 표면 항원을 나타내기 때문에 수행하였다.

배양물을 35×10mm 페트리 접시(Nunc#174926)내에 최종 부피 1.0mL로 3개씩 준비하였다. 배양기는 Terry Fox Labs로부터 구입하였다. HCC-4230배지(Terry Fox Labs, Vancouver, B.C., Canada) 및 에리트로포에틴 (Amgen, Thousand Oak, CA.)을 배양기에 가하였다. 3,000-10,000 CD34+ 세포를 접시마다 가하였다. 트랜스펙트된 포유동물세포로부터의 조건 배지중 또는 트랜스펙트된 포유동물 세포나 E. coli 의 조건배지로부터 정제된 다기능 키메라 조혈수용체 아고니스트 단백질 및 포유동물 세포나 E. coli로부터 정제된 재조합 IL-3를 가하여 0.001 nM 내지 10nM 범위의 최종농도가 되게 하였다. 재조합 hIL-3, GM-CSF, c-mpl 리간드 및 다기능 키메라 조혈수용체 아고니스트는 하우스에서 공급된다. G-CSF(Neupogen)은 Amgen(Thousand Oaks Calf.)로부터 얻었다. 3cc 주사를 이용하여 배양물을 재현탁하고 1.0mL을 접시에 분배하였다. 대조(기저 반응)배양물은 콜로니자극인자를 받지 못하였다. 양성 대조 배양은 조건 배지를 받았다(PHA 자극된 사람 세포: Terry Fox Lab. H2400). 배양을 가습 공기중 37℃ 5CO₂에서 배양하였다.

50세포이상으로 정의되는 조혈 콜로니를 최고 반응이 있는 날(10-11일)에 40x 대물렌즈 조합을 구비한 Nikon 역상 현미경을 이용하여 카운트하였다. 50 세포이하을 포함한 세포군을 클러스터라고 하였다.

선택적으로 콜로니는 콜로니를 슬라이드에 전개시켜서 확인할수 있고 염색할수도 있고 또는 골라내어 재현탁시켜 염색을 위하여 세포스핀 슬라이드에 잡아늘릴수도 있다.

사람 제대혈 조혈 성장 인자 분석

골수는 전통적으로 조혈콜로니자극인자 활성의 체외의 분석에 이용되왔다. 그러나, 사람 골수는 항상 이용가능한 것이 아니며, 기증자 사이에 상당한 변수가 있다. 제혈은 조혈 간세포 및 부모세포의 공급원으로써 골수와 비교된다(Broxmeyeret al., PNAS USA 89:4109-113, 1992; Mayani et al., Blood 81:3252-3258, 1993). 골수와 반대로 제혈은 정규의 베이스 상에서 보다 쉽게 이용가능하다. 또한 여러 기증자로부터 신선하게 얻은 세포를 합해서 분석상의 변화를 감소하고 또는 이 목적을 위하여 냉동저장된 세포의 은행을 생성하는 잠재력도 있다. 배양 조건을 수식함으로써, 및/또는 연결특이성 마커에 대해 분석함으로써, 과립세포/대식세포 콜로니(CFU-GM), 거핵구 CSF 활성, 또는 높은 증식력 콜로니 형성세포(HPP-CFC)의 활성에 대해 특이적으로 분석할수 있다.

방법

단핵 세포(MNC)를 표준밀도구배(1.007 g/mL Histopaque)를 이용해서 수집 24시간내에 제혈로부터 단리하였다. 제대혈MNC를 CD14-, CD34+ 세포에 대한 면역자기 선택; 응용 면역 과학(Santa Clara, CA)의 코팅된 플라스크를 이용한 SBA-, CD34+분획에 대한 패닝(panning); 및 Cellpro(Bothell, WA) 아비딘 칼럼을 이용한 CD34+ 선택을 포함하는 몇가지 방법에 의하여 간세포와 모세포에 대해서 풍부하게 얻었다. 새롭게 단리하거나 또는 냉동저장된 CD34+ 세포가 풍부한 부분을 분석을 위해 사용하였다. 샘플의 각 일련의 희석(1 pM 내지 1204 pM 범위의 농도)에 대하여 2개씩의 배양물을 추가의 성장 인자(Methocult H4230, Stem Cell Technolognies, Vancouver, BC.WP)없는 배지를 포함하는 0.9의 메틸셀롤로오스의 1ml중의 1×10⁴세포와 함께 제조하였다. 몇몇 실험에서는, 에리트로포이에틴(EPO)을 포함하는 Methocult H4330을 Methocult H4230대신에 이용했고, 또는 간세포인자(SCF) 50ng/mL(Biosource International, Camarillo, CA)를 가하였다. 7-9 일간 배양후 30초과의 세포를 포함하는 콜로니를 카운트하였다. 기입시 주관적 선입견을 없애기 위해 분석을 맹검으로 기입하였다.

변종을 생성하고, 그들을 세균, 포유동물 세포 또는 곤충세포에서 발현하는데 이용될수 있는 재조합 DNA방법, 요구하는 단백질의 정제 및 재폴드, 단백질의 생활성을 결정하기 위한 분석에 대한 자세한 설명은 본 명세서에 참고로 그 전체가 포함된 공동-출원 WO 95/00646, WO 94/12639, WO 94/12638, WO 95/20976, WO 95/21197, WO 95/20977, WO 95/21254 및 US 08/383,035에서 찾을 수 있다.

당업자에게 공지된 더 자세한 설명은 여기에 참고로 포함된 T. Maniatis et al., Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory, 1982 및 거기에 인용된 참고문헌; 및 여기에 참고로 포함된 Sambrook et al., Molecular Cloning, A Laboratory Manual, 2nd edition, Cold Spring Harbor Laboratory, 1989 및 거기에 인용된 참고문헌에서 찾을 수 있다.

[표 1]

올리고뉴클레오티드

c-mplNcoI ACGTCCATGGCNTCNCCNGCNCCNCCTGCTTGTGCACTCCGAGTC SEQ ID NO:317

N=A,C,G 또는 T

Ecompl ATGCACGAATTCCCTGACGCAGAGGGTGGA SEQ ID NO:318

c-mplHindIII TGACAAGCTTACCTGACGCAGAGGGTGGACCCT SEQ ID NO:319

4L-5' AATTCGGCAA SEQ ID NO:320

4L-3' CATGTTGCCG SEQ ID NO:321

5L-5' AATTCGGCGGCAA SEQ ID NO:322

5L-3' CATGTTGCCGCCG SEQ ID NO:323

8L-5' AATTCGGCGGCAACGGCGGCAA SEQ ID NO:324

8L-3' CATGTTGCCGCCGTTGCCGCCG SEQ ID NO:325

31-5' CGATCCATGGAGGTTCACCCTTTGCCT SEQ ID NO:326

31-3' GATCAAGCTTATGGGCACTGGCTCAGTCT SEQ ID NO:327

35-5' CGATACATGTTGCCTACACCTGTCCTG SEQ ID NO:328

35-3' GATCAAGCTTAAGGGTGAACCTCTGGGCA SEQ ID NO:329

39-5' CGATCCATGGTCCTGCTGCCTGCTGTG SEQ ID NO:330

39-3' GATCAAGCTTAAGGTGTAGGCAAAGGGTG SEQ ID NO:331

43-5' CGATCCATGGCTGTGGACTTTAGCTTGGGA SEQ ID NO:332

43-3' GATCAAGCTTAAGGCAGCAGGACAGGTGT SEQ ID NO:333

45-5' CGATCCATGGACTTTAGCTTGGGAGAA SEQ ID NO:334

45-3' GATCAAGCTTACACAGCAGGCAGCAGGAC SEQ ID NO:335

49-5' CGATCCATGGGAGAATGGAAAACCCAG SEQ ID NO:336

49-3' GATCAAGCTTACAAGCTAAAGTCCACAGC SEQ ID NO:337

82-5' CGATCCATGGGACCCACTTGCCTCTCA SEQ ID NO:338

82-3' GATCAAGCTTACAGTTGTCCCCGTGCTGC SEQ ID NO:339

109-5' CAGTCCATGGGAACCCAGCTTCCTCCA SEQ ID NO:340

109-3' GATCAAGCTTAAAGGAGGCTCTGCAGGGC SEQ ID NO:341

116-5' CGATCCATGGGCAGGACCACAGCTCAC SEQ ID NO:342

116-3' GATCAAGCTTACTGTGGAGGAAGCTGGGTT SEQ ID NO:343

120-5' CGATCCATGGCTCACAAGGATCCCAATGCC SEQ ID NO:344

120-3' GATCAAGCTTATGTGGTCCTGCCCTGTGG SEQ ID NO:345

123-5' CGATCCATGGATCCCAATGCCATCTTCCTG SEQ ID NO:346

123-3' GATCAAGCTTACTTGTGAGCTGTGGTCCT SEQ ID NO:347

126-5' CGATCCATGGCCATCTTCCTGAGCTTCCAA SEQ ID NO:348

126-3' GATCAAGCTTAATTGGGATCCTTGTGAGCTGT SEQ ID NO:349

SYNNOXA1.REQ AATTCCGTCG TAAACTGACC TTCTATCTGA AAACCTTGGA

GAACGCGCAG GCTCAACAGT ACGTAGAGGG CGGTGGAGGC

TCC SEQ ID NO:350

SYNNOXA2.REQ CCGGGGAGCC TCCACCGCCC TCTACGTACT GTTGAGCCTG

CGCGTTCTCC AAGGTTTTCA GATAGAAGGT CAGTTTACGA

CGG SEQ ID NO:351

L1syn.for GTTACCCTTG AGCAAGCGCA GGAACAACAG GGTGGTGGCT CTAACTGCTC TATAATGAT SEQ ID NO:352

L1syn.rev CGATCATTAT AGAGCAGTTA GAGCCACCAC CCTGTTGTTC CTGCGCTTGC TCAAGG SEQ ID NO:353

L3syn.for GTTACCCTTG AGCAAGCGCA GGAACAACAG GGTGGTGGCT CTGGCGGTGG CAGCGGCGGC GGTTCTAACT GCTCTATAAT GAT

SEQ ID NO:354

L3syn.rev CGATCATTAT AGAGCAGTTA GAACCGCCGC CGCTGCCACC GCCAGAGCCA CCACCCTGTT GTTCCTGCGC TTGCTCAAGG SEQ ID NO:355

35start.seq GATCGACCAT GGCTCTGGAC CCGAACAACC TC SEQ ID NO:356

34rev.seq CTCGATTACG TACAAAGGTG CAGGTGGT SEQ ID NO:357

70start.seq GATCGACCAT GGCTAATGCA TCAGGTATTG AG SEQ ID NO:358

69rev.seq CTCGATTACG TATTCTAAGT TCTTGACA SEQ ID NO:359

91start.seq GATCGACCAT GGCTGCACCC TCTCGACATC CA SEQ ID NO:360

90rev.seq CTCGATTACG TAGGCCGTGG CAGAGGGC SEQ ID NO:361

101start.seq GATCGACCAT GGCTGCAGGT GACTGGCAAG AA SEQ ID NO:362

100rev.seq CTCGATTACG TACTTGATGA TGATTGGA SEQ ID NO:363

L-11start.seq GCTCTGAGAG CCGCCAGAGC CGCCAGAGGG

CTGCGCAAGG TGGCGTAGAA CGCG SEQ ID NO:364

L-11stop.seq CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG

AGCTTCCTGC TCAAGTCTTT AGAG SEQ ID NO:365

P-blstart.seq GGGCTGCGCA AGGTGGCG SEQ ID NO:366

P-blstop.seq ACACCATTGG GCCCTGCCAG C SEQ ID NO:367

39start.seq GATCGACCAT GGCTTACAAG CTGTGCCACC CC SEQ ID NO:368

38stop.Seq CGATCGAAGC TTATTAGGTG GCACACAGCT TCTCCT SEQ ID NO:369

97start.seq GATCGACCAT GGCTCCCGAG TTGGGTCCCA CC SEQ ID NO:370

96stop.Seq CGATCGAAGC TTATTAGGAT ATCCCTTCCA GGGCCT SEQ ID NO:371

126start.seq GATCGACCAT GGCTATGGCC CCTGCCCTGC AG SEQ ID NO:372

125stop.Seq CGATCGAAGC TTATTATCCC AGTTCTTCCA TCTGCT SEQ ID NO:373

133start.seq GATCGACCAT GGCTACCCAG GGTGCCATGC CG SEQ ID NO:374

132stop.seq CGATCGAAGC TTATTAGGGC TGCAGGGCAG GGGCCA SEQ ID NO:375

142start.seq GATCGACCAT GGCTTCTGCT TTCCAGCGCC GG SEQ ID NO:376

141stop.Seq CGATCGAAGC TTATTAGGCG AAGGCCGGCA TGGCAC SEQ ID NO:377

GLYXA1 GTAGAGGGCG GTGGAGGCTC C SEQ ID NO:378

GLYXA2 CCGGGGAGCC TCCACCGCCC TCTAC SEQ ID NO:379

1GGGSfor TTCTACGCCA CCTTGCGCAG CCCGGCGGCG GCTCTGACAT GTCTACACCA TTG SEQ ID NO:380

1GGGSrev CAATGGTGTA GACATGTCAG AGCCGCCGCC GGGCTGCGCA AGGTGGCGTA GAA SEQ ID NO:381

NCOFLT CTGACCATGGCNACCCAGGACTGCTCCTTCCAA SEQ ID NO:807

HIND160 ACTGAAGCTTAGGGCTGACACTGCAGCTCCAG SEQ ID NO:808

HIND165 ACTGAAGCTTACAGGGTTGAGGAGTCGGGCTG SEQ ID NO:809

FL23For GACTGCCATGGCNACYCAGGAYTGYTCYTTYCAACACAGCCCCATC SEQ ID NO:810

FH3AFor GACTGCCATGGCNACYCAGGAYTGYTCYTTYCAACACAGCCCCATC SEQ ID NO:811

SCF.REV TGTCCAAACTCATCAATGTATC SEQ ID NO:812

39FOR CATGGCCATGGCCGACGAGGAGCTCTGCGGGGGCCTCT SEQ ID NO:813

39REV GCTAGAAGCTTACTGCAGGTTGGAGGCCACGGTGAC SEQ ID NO:814

65FOR CATGGCCATGGCCTCCAAGATGCAAGGCTTGCTGGAGC SEQ ID NO:815

65REV GCTAGAAGCTTACCCAGCGACAGTCTTGAGCCGCTC SEQ ID NO:816

89FOR CATGGCCATGGCCCCCCCCAGCTGTCTTCGCTTCGT SEQ ID NO:817

89REV GCTAGAAGCTTAGGGCTGAAAGGCACATTTGGTGACA SEQ ID NO:818

L5A CCCTGTCTGGCGGCAACGGCACCCAGGACTGCTCCTTCCAAC SEQ ID NO:819

L10A GCGGTAACGGCAGTGGAGGTAATGGCACCCAGGACTGCTCCTTCCAAC SEQ ID

NO:820

L15A ACGGCAGTGGTGGCAATGGGAGCGGCGGAAATGGAACCCAGGACT

GCTCCTTCCAAC SEQ ID NO:821

L5B GTGCCGTTGCCGCCAGACAGGGTTGAGGAGTCGGGCTG SEQ ID NO:822

L10B ATTACCTCCACTGCCGTTACCGCCTGACAGGGTTGAGGAGTCGGG CTG SEQ ID

NO:823

L15B GCTCCCATTGCCACCACTGCCGTTACCTCCAGACAGGGTTGAGGA GTCGGGCTG SEQ ID NO:824

L15C GATGAGGATCCGGTGGCAATGGGAGCGGCGGAAATGGAACCCAGG ACTGCTCCTTCCACC SEQ ID NO:825

L15D GATGACGGATCCGTTACCTCCAGACAGGGTTGAGGAGTCGGGCTG SEQ ID NO:826

L15E GATGACGGATCCGGAGGTAATGGCACCCAGGACTGCTCCTTCCAAC SEQ ID NO:827

339FOR2 GACTGCCATGGCCGACGAGGAGCTCTGCG SEQ ID NO:828

339REV2 GACTCAAGCTTACTGCAGGTTGGAGGCC SEQ ID NO:829

339-10FOR3 GACTCGGGATCCGGAGGTTCTGGCACCCAGGACTGCTCC SEQ ID NO:830

339-15FOR2 GACTGGGATCCGGTGGCAGTGGGAGCGGCGGATCTGGAACC SEQ ID NO:831

339REV3 GACTTGGGATCCACTACCTCCAGACAGGGTTGAGGA GTC SEQ ID NO:832

FLN3 ACTGACGGATCCACCGCCCAGGGTTGAGGAGTCGGGCTG SEQ ID NO:833

FLN7 ACTGACGGATCCACCTCCTGACCCACCGCCCAGGGTTGAGGAGTCGGGCTG SEQ ID

NO:834

FLN11 ACTGACGGATCCACCTCCTGACCCACCTCCTGACCCACCGCCCAG GGTTGAGGAGTCGGGCTG SEQ ID NO:835

C-term ACGTAAAGCTTACAGGGTTGAGGAGTCG SEQ ID NO:836

FLC3 GTCAGTGGATCCGGAGGTACCCAGGACTGCTCCTTCCAA C SEQ ID NO:837

FLC4 GTCAGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAAC SEQ ID NO:838

FLC10 TCAGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAG GACTGCTCCTTCCAAC SEQ ID NO:839

N-term TAGTCCATGGCCACCCAGGACTGCTCC SEQ ID NO:840

134.rev GCATTACGTAGGGCTGACACTGCAGCTCCAG SEQ ID NO:841

139.rev GCATTACGTACAGGGTTGAGGAGTCGGGCTG SEQ ID NO:842

Fl29for GTCAGACCATGGCCGATTACCCAGTCACCGTGGCCTC SEQ ID NO:843;

FL29rev TCTGACAAGCTTATTGAAGCAGGTAGTCAGACAGCTCAC SEQ ID NO:844;

FL35for GTCAGCCCATGGCCGCCTCCAACCTGCAGGACGAGGA SEQ ID NO:845;

FL35rev TCTGACAAGCTTACACGGTGACTGGGTAACTTGAAGC SEQ ID NO:846;

FL63for GTCAGACCATGGCCGTCGCTGGGTCCAAGATGCAAGGC SEQ ID NO:847;

FL63rev TCTGACAAGCTTAAGTCTTGAGCCGCTCCATCCAGCG SEQ ID NO:848;

FL95for GTCAGACCATGGCCCGCTTCGTCCAGACCAACATCTCC SEQ ID NO:849;

FL95rev TCTGACAAGCTTAAAGACAGCTGGGGGGGGGCTGAA SEQ ID NO:850;

FL99for GTCAGACCATGGCCACCAACATCTCCCGCCTCCTGCAG SEQ ID NO:851;

FL99rev CTCGACAAGCTTACTGGACGAAGCGAAGACAGCTGGG SEQ ID NO:852;

FLTAFLS1 GATCACATGTCTACAAATCAAGATCTGCCTGTG SEQ ID NO:853

FLTR1N GATCGAATTCGTTGTCTTGGATGAAAGGGA SEQ ID NO:854

HGCFOR ACTTGAATTCATCATCCTGGGCCTGTTCGGGC SEQ ID NO:855

HGCREV ACTCAAGCTTAGAAGCTCCCCAGCGCCTCC SEQ ID NO:856

FL29FOR GTCAGACCATGGCCGATTACCCAGTCACCGTGGCCTC SEQ ID NO:382

FL35FOR GTCAGCCCATGGCCGCCTCCAACCTGCAGGACGAGGA SEQ ID NO:383

FL63FOR GTCAGACCATGGCCGTCGCTGGGTCCAAGATGCAAGGC SEQ ID NO:384

FL95FOR GTCAGACCATGGCCCGCTTCGTCCAGACCAACATCTCC SEQ ID NO:385

FL99FOR GTCAGACCATGGCCACCAACATCTCCCGCCTCCTGCAG SEQ ID NO:386

FL29REV TCTGACAAGCTTATTGAAGCAGGTAGTCAGACAGCTCAC SEQ ID NO:387

FL35REV TCTGACAAGCTTACACGGTGACTGGGTAATCTTGAAGC SEQ ID NO:388

FL63REV TCTGACAAGCTTAAGTCTTGAGCCGCTCCATCCAGCG SEQ ID NO:389

89 REVSTOP GTCAAGAAGCTTACGGCTGAAAGGCACATTTG SEQ ID NO:390

FL95REV TCTGACAAGCTTAAAGACAGCTGGGGGGGGGCTGAA SEQ ID NO:391

FL99REV CTCGACAAGCTTACTGGACGAAGCGAAGACAGCTGGG SEQ ID NO:392

Flt36 GTTGCCATGGCNTCNAAYCTGCARGAYGARGARCTGT

GCGGGGGCCTCTGGCGGCTG SEQ ID NO:393

Flt37 GTTGCCATGGCNAAYCTGCARGAYGARGARCTGTGYG

GGGGCCTCTGGCGGCTGGTC SEQ ID NO:394

Flt38 GTTGCCATGGCNCTGCARGAYGARGARCTGTGYGGYG GCCTCTGGCGGCTGGTCCTG SEQ ID NO:395

Flt39 GTTGCCATGGCNCARGAYGARGARCTGTGYGGYGGYC

TCTGGCGGCTGGTCCTGGCA SEQ ID NO:396

Flt40 GTTGCCATGGCNGAYGARGARCTGTGYGGYGGYCTCT

GGCGGCTGGTCCTGGCACAG SEQ ID NO:397

Flt41 GTTGCCATGGCNGARGARCTGTGYGGYGGYCTCTGGC

GGCTGGTCCTGGCACAGCGC SEQ ID NO:398

Flt42 GTTGCCATGGCNGARCTGTGYGGYGGYCTGTGGCGYC

TGGTCCTGGCACAGCGCTGG SEQ ID NO:399

Flt43 GTTGCCATGGCNCTGTGYGGYGGYCTGTGGCGYCTGG TCCTGGCACAGCGCTGGATG SEQ ID NO:400

40 COLI GTTGCCATGGCWGATGAAGAACTGTGTGGNGGNCTGTGGCGG SEQ ID NO:401

36REV TATGCAAGCTTAGGCCACGGTGACTGGGTA SEQ ID NO:402

37REV TATGCAAGCTTAGGAGGCCACGGTGACTGG SEQ ID NO:403

38REV TATGCAAGCTTAGTTGGAGGCCACGGTGAC SEQ ID NO:404

39REV TATGCAAGCTTACAGGTTGGAGGCCACGGT SEQ ID NO:405

41REV TATGCAAGCTTAGTCCAGGTTGGAGGCCAC SEQ ID NO:406

42REV TATGCAAGCTTACTCGTCCAGGTTGGAGGC SEQ ID NO:407

43REV TATGCAAGCTTACTCCTCGTCCAGGTTGGA SEQ ID NO:408

39N TERM-2 GACTAGCCATGGCNGAYGARGARCTGTGYGGTGGCCTCTGGCGG SEQ ID NO:409

SNA B1CTERM GACTAGTACGTACTGCAGGTTGGAGGCCACGG SEQ ID NO:410

29SMB1 GCAGGTTACGTATTGAAGCAGGTAGTCAGACAGCTC SEQ ID NO:411

34SNAB1 GCAGGTTACGTACACGGTGACTGGGTAATCTTGAAG SEQ ID NO:412

63SNAB1 GCAGGTTACGTAAGTCTTGAGCCGCTCCATCCAGC SEQ ID NO:413

66SNAB1 GCAGGTTACGTAGCCAGCGACAGTCTTGAGCCGCTC SEQ ID NO:414

89N-TERMCSLI GTCAAGCCATGGCNCCRCCRAGCTGTCTRCGCT

TCGTTCAGACCAACTC SEQ ID NO:415

89SNAB1 GCAGGTTACGTACGGCTGAAAGGCACATTTGGTGACAA SEQ ID NO:416

945 SMB1 GCAGGTTACGTAAAGACAGCTGGGGGGGGG SEQ ID NO:417

98SUAB1 GCAGGTTACGTACTGGACGAAGCGAAGACAGCTG SEQ ID NO:418

BAM FOR 1 TCAGTTGGATCCGGCGGCGGAAGCGGAGGTGGCTCTGGGGGAGGTA SEQ ID NO:426

BAM REV 1 TCAGTTGGATCCTCCGCCAGAACCACCGCCTGACCCACCTCCTGACCC

SEQ ID NO:427

NAVREV L GTCTGAGGCGCCACCGCACCGACCGCTGGACAACCGCCTCTGACCC AGGACTGCTCCTTC SEQ ID NO:428

NAVREV S GTCTGAGGCGCCACCGCACCGACCACCCAGGACTGCTCCTTCCAAC SEQ ID NO:429

NAVFOR GTCTGAGGCGCCGAGTGGACGCGGGCTCCACGGTGGCGGCAGGGT TGAGGAGTCGGGCTG SEQ ID NO:430

XBAFOR1 GCTACGTCTAGATCTCCTGACCTCGACCCAGGACTGCTCCTTCCAAC SEQ ID NO:447

XBAREV1 GCTAGTTCTAGACCATCCTGGCTGACACGGTGAAACACCGTCTCTACG

GGCTGACACTGCAGCTCCAG SEQ ID NO:448

LNK1FOR GTCAGTACTAGTATGGGTGTCCGGGCTCTTCGGCTCCTGCAGG

TTGGAGGCCACGG SEQ ID NO:449

LNK1REV GTCAGTACTAGTCCGCCATCTCCGACACCATTAGGCCCTGCCAGC SEQ ID NO:450

LNK2FOR GTCAGTTCCGGAGATTTCGGTTCTGCAGAGGGCTGCGCAAGG

TGGCGTA SEQ ID NO:451

LNK2REV GTCAGTTCCGGATACTCATACCAGCCCGCCATCCCCGGGTTCTA

ATCTGCAAGATGAAGAGCTG SEQ ID NO:452

LNK7FOR GTCAGTACTAGTATGGGTGTCCGGGCTCTTCGGAAAGGCACATTT

GGTGACAAAGTGTATC SEQ ID NO:453

LNK7REV GTCAGTACTAGTCCGCCATCTCCGGGTACACCATTAGGCCCTG

CCAGC SEQ ID NO:454

LNK8REV GTCAGTTCCGGATACTCATACCAGCCCGCCATCCCCGGGTAAGGCC

TTTCAGCCCCCCCCCAG SEQ ID NO:455

C1FOR GTCAGACCATGGCCACTCAGGACTCCTCTTTTC SEQ ID NO:456

C3FOR CACTTTGTCACCAAATCTGCCTTTCAG SEQ ID NO:457

C3REV CTGAAAGGCAGATTTGGTGACAAAGTG SEQ ID NO:458

C5FOR GCCCCCCCCCAGCTCTCTTCG SEQ ID NO:459

C5REV CGAAGAGAGCTGGGGGGGGGC SEQ ID NO:460

C6REV GTCAGTTACGTACAGGGTTGAAGGAGTCGGGCTGAGACTGC SEQ ID NO:461

GPFOR1 GTCAGTCCATGGCTACTCAAGGTGCTATGC SEQ ID NO:462

GPREV2 GTAGCATACGTAGGGCTGCAGGGCAGGGGCC SEQ ID NO:463

[표 2]

유전자 서열

pMON30304

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACCC GAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCT TCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGT CTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCG GGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAG GCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAA TCTCCAAACATGT SEQ ID NO:1

pMON26458

TCCCCAGCTCCACCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAG CAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCT TGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTG GAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGG ACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCA CAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTG ATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTC SEQ ID NO:2

pMON28548

TCCCCAGCTCCACCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAG CAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCT TGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTG GAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCT CATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACC CAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCT GCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCA ACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTC CTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGA CTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCC TTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAG CTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGGGCAGGACCACAGC TCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGC TTGTAGGAGGGTCCACCCTCTGCGTCAGG SEQ ID NO:3

pMON28500

TCCCCAGCTCCACCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAG CAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCT TGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTG GAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGG ACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCA CAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTG ATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTG TGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAG AGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAG ATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAG GGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACA GGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAG CTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATG CTTGTAGGAGGGTCCACCCTCTGCGTCAGG SEQ ID NO:4

pMON28501

TCCCCAGCTCCACCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAG CAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCT TGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTG GAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGG ACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCA CAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTG ATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGC TTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCC CAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACC CAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGC ACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCC TTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCC AATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTC CACCCTCTGCGTCAGG SEQ ID NO:5

pMON28502

TCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAG CAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGC TGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAG TGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTG GGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCC ACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAA AGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGGCGGCAAC ATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCT TCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACT TTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTT CTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCT TTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCA GGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGT TTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGG

SEQ ID NO:6

Syntan1

1 CATGGCTAAC TGCTCTATAA TGATCGATGA AATTATACAT CACTTAAAGA

51 GACCACCTGC ACCTTTGCTG GACCCGAACA ACCTCAATGA CGAAGACGTC

101 TCTATCCTGA TGGACCGAAA CCTTCGACTT CCAAACCTGG AGAGCTTCGT

151 AAGGGCTGTC AAGAACTTAG AAAATGCATC AGGTATTGAG GCAATTCTTC

201 GTAATCTCCA ACCATGTCTG CCCTCTGCCA CGGCCGCACC CTCTCGACAT

251 CCAATCATCA TCAAGGCAGG TGACTGGCAA GAATTCCGGG AAAAACTGAC

301 GTTCTATCTG GTTACCCTTG AGCAAGCGCA GGAACAACAG GGTGGTGGCT

351 CTAACTGCTC TATAATGATC GATGAAATTA TACATCACTT AAAGAGACCA

401 CCTGCACCTT TGCTGGACCC GAACAACCTC AATGACGAAG ACGTCTCTAT

451 CCTGATGGAC CGAAACCTTC GACTTCCAAA CCTGGAGAGC TTCGTAAGGG

501 CTGTCAAGAA CTTAGAAAAT GCATCAGGTA TTGAGGCAAT TCTTCGTAAT

551 CTCCAACCAT GTCTGCCCTC TGCCACGGCC GCACCCTCTC GACATCCAAT

601 CATCATCAAG GCAGGTGACT GGCAAGAATT CCGGGAAAAA CTGACGTTCT

651 ATCTGGTTAC CCTTGAGCAA GCGCAGGAAC AACAGTAC

SEQ ID NO:7

Syntan3

1 CATGGCTAAC TGCTCTATAA TGATCGATGA AATTATACAT CACTTAAAGA

51 GACCACCTGC ACCTTTGCTG GACCCGAACA ACCTCAATGA CGAAGACGTC

101 TCTATCCTGA TGGACCGAAA CCTTCGACTT CCAAACCTGG AGAGCTTCGT

151 AAGGGCTGTC AAGAACTTAG AAAATGCATC AGGTATTGAG GCAATTCTTC

201 GTAATCTCCA ACCATGTCTG CCCTCTGCCA CGGCCGCACC CTCTCGACAT

251 CCAATCATCA TCAAGGCAGG TGACTGGCAA GAATTCCGGG AAAAACTGAC

301 GTTCTATCTG GTTACCCTTG AGCAAGCGCA GGAACAACAG GGTGGTGGCT

351 CTGGCGGTGG CAGCGGCGGC GGTTCTAACT GCTCTATAAT GATCGATGAA

401 ATTATACATC ACTTAAAGAG ACCACCTGCA CCTTTGCTGG ACCCGAACAA

451 CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC CTTCGACTTC

501 CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA

551 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC

601 GGCCGCACCC TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG

651 AATTCCGGGA AAAACTGACG TTCTATCTGG TTACCCTTGA GCAAGCGCAG

701 GAACAACAGT AC SEQ ID NO:8

pMON31104

1 ATGGCTCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT

51 GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA

101 AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG TAATCTCCAA

151 CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC CAATCATCAT

201 CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG TTCTATCTGG

251 TTACCCTTGA GCAAGCGCAG GAACAACAGG GTGGTGGCTC TAACTGCTCT

301 ATAATGATCG ATGAAATTAT ACATCACTTA AAGAGACCAC CTGCACCTTT

351 GTACGTAGAG GGCGGTGGAG GCTCCCCGGG TGAACCGTCT GGTCCAATCT

401 CTACTATCAA CCCGTCTCCT CCGTCTAAAG AATCTCATAA ATCTCCAAAC

451 ATGGCTACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG

501 GGCAGGAGGG GTCCTGGTTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT

551 CGTACCGCGT TCTACGCCAC CTTGCGCAGC CCTCTGGCGG CTCTGGCGGC

601 TCTCAGAGCT TCCTGCTCAA GTCTTTAGAG CAAGTGAGAA AGATCCAGGG

651 CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC AAGCTGTGCC

701 ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT

751 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG

801 CCAACTCCAT AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG

851 AAGGGATATC CCCCGAGTTG GGTCCCACCT TGGACACACT GCAGCTGGAC

901 GTCGCCGACT TTGCCACCAC CATCTGGCAG CAGATGGAAG AACTGGGAAT

951 GGCCCCTGCC CTGCAGCCCT AATAA SEQ ID NO:9

pMON31105

1 ATGGCTAATG CATCAGGTAT TGAGGCAATT CTTCGTAATC TCCAACCATG

51 TCTGCCCTCT GCCACGGCCG CACCCTCTCG ACATCCAATC ATCATCAAGG

101 CAGGTGACTG GCAAGAATTC CGGGAAAAAC TGACGTTCTA TCTGGTTACC

151 CTTGAGCAAG CGCAGGAACA ACAGGGTGGT GGCTCTAACT GCTCTATAAT

201 GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA CCTTTGCTGG

251 ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC

301 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA

351 ATACGTAGAG GGCGGTGGAG GCTCCCCGGG TGAACCGTCT GGTCCAATCT

401 CTACTATCAA CCCGTCTCCT CCGTCTAAAG AATCTCATAA ATCTCCAAAC

451 ATGGCTACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG

501 GGCAGGAGGG GTCCTGGTTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT

551 CGTACCGCGT TCTACGCCAC CTTGCGCAGC CCTCTGGCGG CTCTGGCGGC

601 TCTCAGAGCT TCCTGCTCAA GTCTTTAGAG CAAGTGAGAA AGATCCAGGG

651 CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC AAGCTGTGCC

701 ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT

751 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG

801 CCAACTCCAT AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG

851 AAGGGATATC CCCCGAGTTG GGTCCCACCT TGGACACACT GCAGCTGGAC

901 GTCGCCGACT TTGCCACCAC CATCTGGCAG CAGATGGAAG AACTGGGAAT

951 GGCCCCTGCC CTGCAGCCCT AATAA SEQ ID NO:10

pMON31106

1 ATGGCTGCAC CCTCTCGACA TCCAATCATC ATCAAGGCAG GTGACTGGCA

51 AGAATTCCGG GAAAAACTGA CGTTCTATCT GGTTACCCTT GAGCAAGCGC

101 AGGAACAACA GGGTGGTGGC TCTAACTGCT CTATAATGAT CGATGAAATT

151 ATACATCACT TAAAGAGACC ACCTGCACCT TTGCTGGACC CGAACAACCT

201 CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT CGACTTCCAA

251 ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT

301 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC

351 CTACGTAGAG GGCGGTGGAG GCTCCCCGGG TGAACCGTCT GGTCCAATCT

401 CTACTATCAA CCCGTCTCCT CCGTCTAAAG AATCTCATAA ATCTCCAAAC

451 ATGGCTACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG

501 GGCAGGAGGG GTCCTGGTTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT

551 CGTACCGCGT TCTACGCCAC CTTGCGCAGC CCTCTGGCGG CTCTGGCGGC

601 TCTCAGAGCT TCCTGCTCAA GTCTTTAGAG CAAGTGAGAA AGATCCAGGG

651 CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC AAGCTGTGCC

701 ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT

751 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG

801 CCAACTCCAT AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG

851 AAGGGATATC CCCCGAGTTG GGTCCCACCT TGGACACACT GCAGCTGGAC

901 GTCGCCGACT TTGCCACCAC CATCTGGCAG CAGATGGAAG AACTGGGAAT

951 GGCCCCTGCC CTGCAGCCCT AATAA SEQ ID NO:11

pMON31107

1 ATGGCTGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGTTCTATCT

51 GGTTACCCTT GAGCAAGCGC AGGAACAACA GGGTGGTGGC TCTAACTGCT

101 CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT

151 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA

201 CCGAAACCTT CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA

251 ACTTAGAAAA TGCATCAGGT ATTGAGGCAA TTCTTCGTAA TCTCCAACCA

301 TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA

351 GTACGTAGAG GGCGGTGGAG GCTCCCCGGG TGAACCGTCT GGTCCAATCT

401 CTACTATCAA CCCGTCTCCT CCGTCTAAAG AATCTCATAA ATCTCCAAAC

451 ATGGCTACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG

501 GGCAGGAGGG GTCCTGGTTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT

551 CGTACCGCGT TCTACGCCAC CTTGCGCAGC CCTCTGGCGG CTCTGGCGGC

601 TCTCAGAGCT TCCTGCTCAA GTCTTTAGAG CAAGTGAGAA AGATCCAGGG

651 CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC AAGCTGTGCC

701 ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT

751 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG

801 CCAACTCCAT AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG

851 AAGGGATATC CCCCGAGTTG GGTCCCACCT TGGACACACT GCAGCTGGAC

901 GTCGCCGACT TTGCCACCAC CATCTGGCAG CAGATGGAAG AACTGGGAAT

951 GGCCCCTGCC CTGCAGCCCT AATAA SEQ ID NO:12

pMON31108

1 ATGGCTCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT

51 GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA

101 AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG TAATCTCCAA

151 CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC CAATCATCAT

201 CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG TTCTATCTGG

251 TTACCCTTGA GCAAGCGCAG GAACAACAGG GTGGTGGCTC TGGCGGTGGC

301 AGCGGCGGCG GTTCTAACTG CTCTATAATG ATCGATGAAA TTATACATCA

351 CTTAAAGAGA CCACCTGCAC CTTTGTACGT AGAGGGCGGT GGAGGCTCCC

401 CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT

451 AAAGAATCTC ATAAATCTCC AAACATGGCT ACCCAGGGTG CCATGCCGGC

501 CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG GTTGCTAGCC

551 ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG

601 CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCAAGTCTTT

651 AGAGCAAGTG AGAAAGATCC AGGGCGATGG CGCAGCGCTC CAGGAGAAGC

701 TGTGTGCCAC CTACAAGCTG TGCCACCCCG AGGAGCTGGT GCTGCTCGGA

751 CACTCTCTGG GCATCCCCTG GGCTCCCCTG AGCTCCTGCC CCAGCCAGGC

801 CCTGCAGCTG GCAGGCTGCT TGAGCCAACT CCATAGCGGC CTTTTCCTCT

851 ACCAGGGGCT CCTGCAGGCC CTGGAAGGGA TATCCCCCGA GTTGGGTCCC

901 ACCTTGGACA CACTGCAGCT GGACGTCGCC GACTTTGCCA CCACCATCTG

951 GCAGCAGATG GAAGAACTGG GAATGGCCCC TGCCCTGCAG CCCTAATAA

SEQ ID NO:13

pMON31109

1 ATGGCTAATG CATCAGGTAT TGAGGCAATT CTTCGTAATC TCCAACCATG

51 TCTGCCCTCT GCCACGGCCG CACCCTCTCG ACATCCAATC ATCATCAAGG

101 CAGGTGACTG GCAAGAATTC CGGGAAAAAC TGACGTTCTA TCTGGTTACC

151 CTTGAGCAAG CGCAGGAACA ACAGGGTGGT GGCTCTGGCG GTGGCAGCGG

201 CGGCGGTTCT AACTGCTCTA TAATGATCGA TGAAATTATA CATCACTTAA

251 AGAGACCACC TGCACCTTTG CTGGACCCGA ACAACCTCAA TGACGAAGAC

301 GTCTCTATCC TGATGGACCG AAACCTTCGA CTTCCAAACC TGGAGAGCTT

351 CGTAAGGGCT GTCAAGAACT TAGAATACGT AGAGGGCGGT GGAGGCTCCC

401 CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT

451 AAAGAATCTC ATAAATCTCC AAACATGGCT ACCCAGGGTG CCATGCCGGC

501 CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG GTTGCTAGCC

551 ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG

601 CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCAAGTCTTT

651 AGAGCAAGTG AGAAAGATCC AGGGCGATGG CGCAGCGCTC CAGGAGAAGC

701 TGTGTGCCAC CTACAAGCTG TGCCACCCCG AGGAGCTGGT GCTGCTCGGA

751 CACTCTCTGG GCATCCCCTG GGCTCCCCTG AGCTCCTGCC CCAGCCAGGC

801 CCTGCAGCTG GCAGGCTGCT TGAGCCAACT CCATAGCGGC CTTTTCCTCT

851 ACCAGGGGCT CCTGCAGGCC CTGGAAGGGA TATCCCCCGA GTTGGGTCCC

901 ACCTTGGACA CACTGCAGCT GGACGTCGCC GACTTTGCCA CCACCATCTG

951 GCAGCAGATG GAAGAACTGG GAATGGCCCC TGCCCTGCAG CCCTAATAA

SEQ ID NO:14

pMON31110

1 ATGGCTGCAC CCTCTCGACA TCCAATCATC ATCAAGGCAG GTGACTGGCA

51 AGAATTCCGG GAAAAACTGA CGTTCTATCT GGTTACCCTT GAGCAAGCGC

101 AGGAACAACA GGGTGGTGGC TCTGGCGGTG GCAGCGGCGG CGGTTCTAAC

151 TGCTCTATAA TGATCGATGA AATTATACAT CACTTAAAGA GACCACCTGC

201 ACCTTTGCTG GACCCGAACA ACCTCAATGA CGAAGACGTC TCTATCCTGA

251 TGGACCGAAA CCTTCGACTT CCAAACCTGG AGAGCTTCGT AAGGGCTGTC

301 AAGAACTTAG AAAATGCATC AGGTATTGAG GCAATTCTTC GTAATCTCCA

351 ACCATGTCTG CCCTCTGCCA CGGCCTACGT AGAGGGCGGT GGAGGCTCCC

401 CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT

451 AAAGAATCTC ATAAATCTCC AAACATGGCT ACCCAGGGTG CCATGCCGGC

501 CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG GTTGCTAGCC

551 ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG

601 CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCAAGTCTTT

651 AGAGCAAGTG AGAAAGATCC AGGGCGATGG CGCAGCGCTC CAGGAGAAGC

701 TGTGTGCCAC CTACAAGCTG TGCCACCCCG AGGAGCTGGT GCTGCTCGGA

751 CACTCTCTGG GCATCCCCTG GGCTCCCCTG AGCTCCTGCC CCAGCCAGGC

801 CCTGCAGCTG GCAGGCTGCT TGAGCCAACT CCATAGCGGC CTTTTCCTCT

851 ACCAGGGGCT CCTGCAGGCC CTGGAAGGGA TATCCCCCGA GTTGGGTCCC

901 ACCTTGGACA CACTGCAGCT GGACGTCGCC GACTTTGCCA CCACCATCTG

951 GCAGCAGATG GAAGAACTGG GAATGGCCCC TGCCCTGCAG CCCTAATAA

SEQ ID NO:15

pMON31111

1 ATGGCTGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGTTCTATCT

51 GGTTACCCTT GAGCAAGCGC AGGAACAACA GGGTGGTGGC TCTGGCGGTG

101 GCAGCGGCGG CGGTTCTAAC TGCTCTATAA TGATCGATGA AATTATACAT

151 CACTTAAAGA GACCACCTGC ACCTTTGCTG GACCCGAACA ACCTCAATGA

201 CGAAGACGTC TCTATCCTGA TGGACCGAAA CCTTCGACTT CCAAACCTGG

251 AGAGCTTCGT AAGGGCTGTC AAGAACTTAG AAAATGCATC AGGTATTGAG

301 GCAATTCTTC GTAATCTCCA ACCATGTCTG CCCTCTGCCA CGGCCGCACC

351 CTCTCGACAT CCAATCATCA TCAAGTACGT AGAGGGCGGT GGAGGCTCCC

401 CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT

451 AAAGAATCTC ATAAATCTCC AAACATGGCT ACCCAGGGTG CCATGCCGGC

501 CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG GTTGCTAGCC

551 ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG

601 CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCAAGTCTTT

651 AGAGCAAGTG AGAAAGATCC AGGGCGATGG CGCAGCGCTC CAGGAGAAGC

701 TGTGTGCCAC CTACAAGCTG TGCCACCCCG AGGAGCTGGT GCTGCTCGGA

751 CACTCTCTGG GCATCCCCTG GGCTCCCCTG AGCTCCTGCC CCAGCCAGGC

801 CCTGCAGCTG GCAGGCTGCT TGAGCCAACT CCATAGCGGC CTTTTCCTCT

851 ACCAGGGGCT CCTGCAGGCC CTGGAAGGGA TATCCCCCGA GTTGGGTCCC

901 ACCTTGGACA CACTGCAGCT GGACGTCGCC GACTTTGCCA CCACCATCTG

951 GCAGCAGATG GAAGAACTGG GAATGGCCCC TGCCCTGCAG CCCTAATAA

SEQ ID NO:16

pMON13182

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTT

401 ACAAGCTGTG CCACCCCGAG GAGCTGGTGC TGCTCGGACA CTCTCTGGGC

451 ATCCCCTGGG CTCCCCTGAG CTCCTGCCCC AGCCAGGCCC TGCAGCTGGC

501 AGGCTGCTTG AGCCAACTCC ATAGCGGCCT TTTCCTCTAC CAGGGGCTCC

551 TGCAGGCCCT GGAAGGGATA TCCCCCGAGT TGGGTCCCAC CTTGGACACA

601 CTGCAGCTGG ACGTCGCCGA CTTTGCCACC ACCATCTGGC AGCAGATGGA

651 AGAACTGGGA ATGGCCCCTG CCCTGCAGCC CACCCAGGGT GCCATGCCGG

701 CCTTCGCCTC TGCTTTCCAG CGCCGGGCAG GAGGGGTCCT GGTTGCTAGC

751 CATCTGCAGA GCTTCCTGGA GGTGTCGTAC CGCGTTCTAC GCCACCTTGC

801 GCAGCCCTCT GGCGGCTCTG GCGGCTCTCA GAGCTTCCTG CTCAAGTCTT

851 TAGAGCAAGT GAGAAAGATC CAGGGCGATG GCGCAGCGCT CCAGGAGAAG

901 CTGTGTGCCA CCTAATAA SEQ ID NO:17

pMON13183

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTTACAAG

451 CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC

501 CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT

551 GCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG

601 GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA

651 GCTGGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC

701 TGGGAATGGC CCCTGCCCTG CAGCCCACCC AGGGTGCCAT GCCGGCCTTC

751 GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGTTG CTAGCCATCT

801 GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC

851 CCTCTGGCGG CTCTGGCGGC TCTCAGAGCT TCCTGCTCAA GTCTTTAGAG

901 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG

951 TGCCACCTAA TAA SEQ ID NO:18

pMON13184

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTC

401 CCGAGTTGGG TCCCACCTTG GACACACTGC AGCTGGACGT CGCCGACTTT

451 GCCACCACCA TCTGGCAGCA GATGGAAGAA CTGGGAATGG CCCCTGCCCT

501 GCAGCCCACC CAGGGTGCCA TGCCGGCCTT CGCCTCTGCT TTCCAGCGCC

551 GGGCAGGAGG GGTCCTGGTT GCTAGCCATC TGCAGAGCTT CCTGGAGGTG

601 TCGTACCGCG TTCTACGCCA CCTTGCGCAG CCCTCTGGCG GCTCTGGCGG

651 CTCTCAGAGC TTCCTGCTCA AGTCTTTAGA GCAAGTGAGA AAGATCCAGG

701 GCGATGGCGC AGCGCTCCAG GAGAAGCTGT GTGCCACCTA CAAGCTGTGC

751 CACCCCGAGG AGCTGGTGCT GCTCGGACAC TCTCTGGGCA TCCCCTGGGC

801 TCCCCTGAGC TCCTGCCCCA GCCAGGCCCT GCAGCTGGCA GGCTGCTTGA

851 GCCAACTCCA TAGCGGCCTT TTCCTCTACC AGGGGCTCCT GCAGGCCCTG

901 GAAGGGATAT CCTAATAA SEQ ID NO:19

pMON13185

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTCCCGAG

451 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC

501 CACCATCTGG CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC

551 CCACCCAGGG TGCCATGCCG GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA

601 GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGCTTCCTGG AGGTGTCGTA

651 CCGCGTTCTA CGCCACCTTG CGCAGCCCTC TGGCGGCTCT GGCGGCTCTC

701 AGAGCTTCCT GCTCAAGTCT TTAGAGCAAG TGAGAAAGAT CCAGGGCGAT

751 GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC ACCTACAAGC TGTGCCACCC

801 CGAGGAGCTG GTGCTGCTCG GACACTCTCT GGGCATCCCC TGGGCTCCCC

851 TGAGCTCCTG CCCCAGCCAG GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA

901 CTCCATAGCG GCCTTTTCCT CTACCAGGGG CTCCTGCAGG CCCTGGAAGG

951 GATATCCTAA TAA SEQ ID NO:20

pMON13186

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA

401 TGGCCCCTGC CCTGCAGCCC ACCCAGGGTG CCATGCCGGC CTTCGCCTCT

451 GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG GTTGCTAGCC ATCTGCAGAG

501 CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG CAGCCCTCTG

551 GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCAAGTCTTT AGAGCAAGTG

601 AGAAAGATCC AGGGCGATGG CGCAGCGCTC CAGGAGAAGC TGTGTGCCAC

651 CTACAAGCTG TGCCACCCCG AGGAGCTGGT GCTGCTCGGA CACTCTCTGG

701 GCATCCCCTG GGCTCCCCTG AGCTCCTGCC CCAGCCAGGC CCTGCAGCTG

751 GCAGGCTGCT TGAGCCAACT CCATAGCGGC CTTTTCCTCT ACCAGGGGCT

801 CCTGCAGGCC CTGGAAGGGA TATCCCCCGA GTTGGGTCCC ACCTTGGACA

851 CACTGCAGCT GGACGTCGCC GACTTTGCCA CCACCATCTG GCAGCAGATG

901 GAAGAACTGG GATAATAA SEQ ID NO:21

pMON13187

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTATGGCC

451 CCTGCCCTGC AGCCCACCCA GGGTGCCATG CCGGCCTTCG CCTCTGCTTT

501 CCAGCGCCGG GCAGGAGGGG TCCTGGTTGC TAGCCATCTG CAGAGCTTCC

551 TGGAGGTGTC GTACCGCGTT CTACGCCACC TTGCGCAGCC CTCTGGCGGC

601 TCTGGCGGCT CTCAGAGCTT CCTGCTCAAG TCTTTAGAGC AAGTGAGAAA

651 GATCCAGGGC GATGGCGCAG CGCTCCAGGA GAAGCTGTGT GCCACCTACA

701 AGCTGTGCCA CCCCGAGGAG CTGGTGCTGC TCGGACACTC TCTGGGCATC

751 CCCTGGGCTC CCCTGAGCTC CTGCCCCAGC CAGGCCCTGC AGCTGGCAGG

801 CTGCTTGAGC CAACTCCATA GCGGCCTTTT CCTCTACCAG GGGCTCCTGC

851 AGGCCCTGGA AGGGATATCC CCCGAGTTGG GTCCCACCTT GGACACACTG

901 CAGCTGGACG TCGCCGACTT TGCCACCACC ATCTGGCAGC AGATGGAAGA

951 ACTGGGATAA TAA SEQ ID NO:22

pMON13188

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA

401 CCCAGGGTGC CATGCCGGCC TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA

451 GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC TTCCTGGAGG TGTCGTACCG

501 CGTTCTACGC CACCTTGCGC AGCCCTCTGG CGGCTCTGGC GGCTCTCAGA

551 GCTTCCTGCT CAAGTCTTTA GAGCAAGTGA GAAAGATCCA GGGCGATGGC

601 GCAGCGCTCC AGGAGAAGCT GTGTGCCACC TACAAGCTGT GCCACCCCGA

651 GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CATCCCCTGG GCTCCCCTGA

701 GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GAGCCAACTC

751 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT

801 ATCCCCCGAG TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG

851 ACTTTGCCAC CACCATCTGG CAGCAGATGG AAGAACTGGG AATGGCCCCT

901 GCCCTGCAGC CCTAATAA SEQ ID NO:23

pMON13189

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTACCCAG

451 GGTGCCATGC CGGCCTTCGC CTCTGCTTTC CAGCGCCGGG CAGGAGGGGT

501 CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG TACCGCGTTC

551 TACGCCACCT TGCGCAGCCC TCTGGCGGCT CTGGCGGCTC TCAGAGCTTC

601 CTGCTCAAGT CTTTAGAGCA AGTGAGAAAG ATCCAGGGCG ATGGCGCAGC

651 GCTCCAGGAG AAGCTGTGTG CCACCTACAA GCTGTGCCAC CCCGAGGAGC

701 TGGTGCTGCT CGGACACTCT CTGGGCATCC CCTGGGCTCC CCTGAGCTCC

751 TGCCCCAGCC AGGCCCTGCA GCTGGCAGGC TGCTTGAGCC AACTCCATAG

801 CGGCCTTTTC CTCTACCAGG GGCTCCTGCA GGCCCTGGAA GGGATATCCC

851 CCGAGTTGGG TCCCACCTTG GACACACTGC AGCTGGACGT CGCCGACTTT

901 GCCACCACCA TCTGGCAGCA GATGGAAGAA CTGGGAATGG CCCCTGCCCT

951 GCAGCCCTAA TAA SEQ ID NO:24

pMON13190

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTT

401 CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CCATCTGCAG

451 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCTC

501 TGGCGGCTCT GGCGGCTCTC AGAGCTTCCT GCTCAAGTCT TTAGAGCAAG

551 TGAGAAAGAT CCAGGGCGAT GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC

601 ACCTACAAGC TGTGCCACCC CGAGGAGCTG GTGCTGCTCG GACACTCTCT

651 GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CCCCAGCCAG GCCCTGCAGC

701 TGGCAGGCTG CTTGAGCCAA CTCCATAGCG GCCTTTTCCT CTACCAGGGG

751 CTCCTGCAGG CCCTGGAAGG GATATCCCCC GAGTTGGGTC CCACCTTGGA

801 CACACTGCAG CTGGACGTCG CCGACTTTGC CACCACCATC TGGCAGCAGA

851 TGGAAGAACT GGGAATGGCC CCTGCCCTGC AGCCCACCCA GGGTGCCATG

901 CCGGCCTTCG CCTAATAA SEQ ID NO:25

pMON13191

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTTCTGCT

451 TTCCAGCGCC GGGCAGGAGG GGTCCTGGTT GCTAGCCATC TGCAGAGCTT

501 CCTGGAGGTG TCGTACCGCG TTCTACGCCA CCTTGCGCAG CCCTCTGGCG

551 GCTCTGGCGG CTCTCAGAGC TTCCTGCTCA AGTCTTTAGA GCAAGTGAGA

601 AAGATCCAGG GCGATGGCGC AGCGCTCCAG GAGAAGCTGT GTGCCACCTA

651 CAAGCTGTGC CACCCCGAGG AGCTGGTGCT GCTCGGACAC TCTCTGGGCA

701 TCCCCTGGGC TCCCCTGAGC TCCTGCCCCA GCCAGGCCCT GCAGCTGGCA

751 GGCTGCTTGA GCCAACTCCA TAGCGGCCTT TTCCTCTACC AGGGGCTCCT

801 GCAGGCCCTG GAAGGGATAT CCCCCGAGTT GGGTCCCACC TTGGACACAC

851 TGCAGCTGGA CGTCGCCGAC TTTGCCACCA CCATCTGGCA GCAGATGGAA

901 GAACTGGGAA TGGCCCCTGC CCTGCAGCCC ACCCAGGGTG CCATGCCGGC

951 CTTCGCCTAA TAA SEQ ID NO:26

pMON13192

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTT

401 ACAAGCTGTG CCACCCCGAG GAGCTGGTGC TGCTCGGACA CTCTCTGGGC

451 ATCCCCTGGG CTCCCCTGAG CTCCTGCCCC AGCCAGGCCC TGCAGCTGGC

501 AGGCTGCTTG AGCCAACTCC ATAGCGGCCT TTTCCTCTAC CAGGGGCTCC

551 TGCAGGCCCT GGAAGGGATA TCCCCCGAGT TGGGTCCCAC CTTGGACACA

601 CTGCAGCTGG ACGTCGCCGA CTTTGCCACC ACCATCTGGC AGCAGATGGA

651 AGAACTGGGA ATGGCCCCTG CCCTGCAGCC CACCCAGGGT GCCATGCCGG

701 CCTTCGCCTC TGCTTTCCAG CGCCGGGCAG GAGGGGTCCT GGTTGCTAGC

751 CATCTGCAGA GCTTCCTGGA GGTGTCGTAC CGCGTTCTAC GCCACCTTGC

801 GCAGCCCACA CCATTGGGCC CTGCCAGCTC CCTGCCCCAG AGCTTCCTGC

851 TCAAGTCTTT AGAGCAAGTG AGAAAGATCC AGGGCGATGG CGCAGCGCTC

901 CAGGAGAAGC TGTGTGCCAC CTAATAA SEQ ID NO:27

pMON13193

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTTACAAG

451 CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC

501 CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT

551 GCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG

601 GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA

651 GCTGGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC

701 TGGGAATGGC CCCTGCCCTG CAGCCCACCC AGGGTGCCAT GCCGGCCTTC

751 GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGTTG CTAGCCATCT

801 GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC

851 CCACACCATT GGGCCCTGCC AGCTCCCTGC CCCAGAGCTT CCTGCTCAAG

901 TCTTTAGAGC AAGTGAGAAA GATCCAGGGC GATGGCGCAG CGCTCCAGGA

951 GAAGCTGTGT GCCACCTAAT AA SEQ ID NO:28

pMON25190

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTC

401 CCGAGTTGGG TCCCACCTTG GACACACTGC AGCTGGACGT CGCCGACTTT

451 GCCACCACCA TCTGGCAGCA GATGGAAGAA CTGGGAATGG CCCCTGCCCT

501 GCAGCCCACC CAGGGTGCCA TGCCGGCCTT CGCCTCTGCT TTCCAGCGCC

551 GGGCAGGAGG GGTCCTGGTT GCTAGCCATC TGCAGAGCTT CCTGGAGGTG

601 TCGTACCGCG TTCTACGCCA CCTTGCGCAG CCCACACCAT TGGGCCCTGC

651 CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG CAAGTGAGAA

701 AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC

751 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT

801 CCCCTGGGCT CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG

851 GCTGCTTGAG CCAACTCCAT AGCGGCCTTT TCCTCTACCA GGGGCTCCTG

901 CAGGCCCTGG AAGGGATATC CTAATAA SEQ ID NO:29

pMON25191

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTCCCGAG

451 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC

501 CACCATCTGG CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC

551 CCACCCAGGG TGCCATGCCG GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA

601 GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGCTTCCTGG AGGTGTCGTA

651 CCGCGTTCTA CGCCACCTTG CGCAGCCCAC ACCATTGGGC CCTGCCAGCT

701 CCCTGCCCCA GAGCTTCCTG CTCAAGTCTT TAGAGCAAGT GAGAAAGATC

751 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT

801 GTGCCACCCC GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT

851 GGGCTCCCCT GAGCTCCTGC CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC

901 TTGAGCCAAC TCCATAGCGG CCTTTTCCTC TACCAGGGGC TCCTGCAGGC

951 CCTGGAAGGG ATATCCTAAT AA SEQ ID NO:30

pMON13194

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA

401 TGGCCCCTGC CCTGCAGCCC ACCCAGGGTG CCATGCCGGC CTTCGCCTCT

451 GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG GTTGCTAGCC ATCTGCAGAG

501 CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG CAGCCCACAC

551 CATTGGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CAAGTCTTTA

601 GAGCAAGTGA GAAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT

651 GTGTGCCACC TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC

701 ACTCTCTGGG CATCCCCTGG GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC

751 CTGCAGCTGG CAGGCTGCTT GAGCCAACTC CATAGCGGCC TTTTCCTCTA

801 CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT ATCCCCCGAG TTGGGTCCCA

851 CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CACCATCTGG

901 CAGCAGATGG AAGAACTGGG ATAATAA SEQ ID NO:31

pMON13195

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTATGGCC

451 CCTGCCCTGC AGCCCACCCA GGGTGCCATG CCGGCCTTCG CCTCTGCTTT

501 CCAGCGCCGG GCAGGAGGGG TCCTGGTTGC TAGCCATCTG CAGAGCTTCC

551 TGGAGGTGTC GTACCGCGTT CTACGCCACC TTGCGCAGCC CACACCATTG

601 GGCCCTGCCA GCTCCCTGCC CCAGAGCTTC CTGCTCAAGT CTTTAGAGCA

651 AGTGAGAAAG ATCCAGGGCG ATGGCGCAGC GCTCCAGGAG AAGCTGTGTG

701 CCACCTACAA GCTGTGCCAC CCCGAGGAGC TGGTGCTGCT CGGACACTCT

751 CTGGGCATCC CCTGGGCTCC CCTGAGCTCC TGCCCCAGCC AGGCCCTGCA

801 GCTGGCAGGC TGCTTGAGCC AACTCCATAG CGGCCTTTTC CTCTACCAGG

851 GGCTCCTGCA GGCCCTGGAA GGGATATCCC CCGAGTTGGG TCCCACCTTG

901 GACACACTGC AGCTGGACGT CGCCGACTTT GCCACCACCA TCTGGCAGCA

951 GATGGAAGAA CTGGGATAAT AA SEQ ID NO:32

pMON13196

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA

401 CCCAGGGTGC CATGCCGGCC TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA

451 GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC TTCCTGGAGG TGTCGTACCG

501 CGTTCTACGC CACCTTGCGC AGCCCACACC ATTGGGCCCT GCCAGCTCCC

551 TGCCCCAGAG CTTCCTGCTC AAGTCTTTAG AGCAAGTGAG AAAGATCCAG

601 GGCGATGGCG CAGCGCTCCA GGAGAAGCTG TGTGCCACCT ACAAGCTGTG

651 CCACCCCGAG GAGCTGGTGC TGCTCGGACA CTCTCTGGGC ATCCCCTGGG

701 CTCCCCTGAG CTCCTGCCCC AGCCAGGCCC TGCAGCTGGC AGGCTGCTTG

751 AGCCAACTCC ATAGCGGCCT TTTCCTCTAC CAGGGGCTCC TGCAGGCCCT

801 GGAAGGGATA TCCCCCGAGT TGGGTCCCAC CTTGGACACA CTGCAGCTGG

851 ACGTCGCCGA CTTTGCCACC ACCATCTGGC AGCAGATGGA AGAACTGGGA

901 ATGGCCCCTG CCCTGCAGCC CTAATAA SEQ ID NO:33

pMON13197

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTACCCAG

451 GGTGCCATGC CGGCCTTCGC CTCTGCTTTC CAGCGCCGGG CAGGAGGGGT

501 CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG TACCGCGTTC

551 TACGCCACCT TGCGCAGCCC ACACCATTGG GCCCTGCCAG CTCCCTGCCC

601 CAGAGCTTCC TGCTCAAGTC TTTAGAGCAA GTGAGAAAGA TCCAGGGCGA

651 TGGCGCAGCG CTCCAGGAGA AGCTGTGTGC CACCTACAAG CTGTGCCACC

701 CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC CTGGGCTCCC

751 CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT GCTTGAGCCA

801 ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG GCCCTGGAAG

851 GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC

901 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC

951 CCCTGCCCTG CAGCCCTAAT AA SEQ ID NO:34

pMON13198

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTT

401 CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CCATCTGCAG

451 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCAC

501 ACCATTGGGC CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTCTT

551 TAGAGCAAGT GAGAAAGATC CAGGGCGATG GCGCAGCGCT CCAGGAGAAG

601 CTGTGTGCCA CCTACAAGCT GTGCCACCCC GAGGAGCTGG TGCTGCTCGG

651 ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC CCCAGCCAGG

701 CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG CCTTTTCCTC

751 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGTTGGGTCC

801 CACCTTGGAC ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT

851 GGCAGCAGAT GGAAGAACTG GGAATGGCCC CTGCCCTGCA GCCCACCCAG

901 GGTGCCATGC CGGCCTTCGC CTAATAA SEQ ID NO:35

pMON13199

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTTCTGCT

451 TTCCAGCGCC GGGCAGGAGG GGTCCTGGTT GCTAGCCATC TGCAGAGCTT

501 CCTGGAGGTG TCGTACCGCG TTCTACGCCA CCTTGCGCAG CCCACACCAT

551 TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG

601 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG

651 TGCCACCTAC AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT

701 CTCTGGGCAT CCCCTGGGCT CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG

751 CAGCTGGCAG GCTGCTTGAG CCAACTCCAT AGCGGCCTTT TCCTCTACCA

801 GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG GGTCCCACCT

851 TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG

901 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC

951 CATGCCGGCC TTCGCCTAAT AA SEQ ID NO:36

pMON31112

1 ATGGCTAACT GCTCTAACAT GATCGATGAA ATCATCACCC ACCTGAAGCA

51 GCCACCGCTG CCGCTGCTGG ACTTCAACAA CCTCAATGGT GAAGACCAAG

101 ATATCCTAAT GGACAATAAC CTTCGTCGTC CAAACCTCGA GGCATTCAAC

151 CGTGCTGTCA AGTCTCTGCA GAATGCATCA GCAATTGAGA GCATTCTTAA

201 AAATCTCCTG CCATGTCTGC CGCTAGCCAC GGCCGCACCC ACGCGACATC

251 CAATCCATAT CAAGGACGGT GACTGGAATG AATTCCGTCG TAAACTGACC

301 TTCTATCTGA AAACCTTGGA GAACGCGCAG GCTCAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTACCCAG

451 GGTGCCATGC CGGCCTTCGC CTCTGCTTTC CAGCGCCGGG CAGGAGGGGT

501 CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG TACCGCGTTC

551 TACGCCACCT TGCGCAGCCC TCTGGCGGCT CTGGCGGCTC TCAGAGCTTC

601 CTGCTCAAGT CTTTAGAGCA AGTGAGAAAG ATCCAGGGCG ATGGCGCAGC

651 GCTCCAGGAG AAGCTGTGTG CCACCTACAA GCTGTGCCAC CCCGAGGAGC

701 TGGTGCTGCT CGGACACTCT CTGGGCATCC CCTGGGCTCC CCTGAGCTCC

751 TGCCCCAGCC AGGCCCTGCA GCTGGCAGGC TGCTTGAGCC AACTCCATAG

801 CGGCCTTTTC CTCTACCAGG GGCTCCTGCA GGCCCTGGAA GGGATATCCC

851 CCGAGTTGGG TCCCACCTTG GACACACTGC AGCTGGACGT CGCCGACTTT

901 GCCACCACCA TCTGGCAGCA GATGGAAGAA CTGGGAATGG CCCCTGCCCT

951 GCAGCCCTAA TAA SEQ ID NO:37

pMON31113

1 ATGGCTAACT GCTCTAACAT GATCGATGAA ATCATCACCC ACCTGAAGCA

51 GCCACCGCTG CCGCTGCTGG ACTTCAACAA CCTCAATGGT GAAGACCAAG

101 ATATCCTGAT GGAAAATAAC CTTCGTCGTC CAAACCTCGA GGCATTCAAC

151 CGTGCTGTCA AGTCTCTGCA GAATGCATCA GCAATTGAGA GCATTCTTAA

201 AAATCTCCTG CCATGTCTGC CCCTGGCCAC GGCCGCACCC ACGCGACATC

251 CAATCATCAT CCGTGACGGT GACTGGAATG AATTCCGTCG TAAACTGACC

301 TTCTATCTGA AAACCTTGGA GAACGCGCAG GCTCAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTACCCAG

451 GGTGCCATGC CGGCCTTCGC CTCTGCTTTC CAGCGCCGGG CAGGAGGGGT

501 CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG TACCGCGTTC

551 TACGCCACCT TGCGCAGCCC ACACCATTGG GCCCTGCCAG CTCCCTGCCC

601 CAGAGCTTCC TGCTCAAGTC TTTAGAGCAA GTGAGAAAGA TCCAGGGCGA

651 TGGCGCAGCG CTCCAGGAGA AGCTGTGTGC CACCTACAAG CTGTGCCACC

701 CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC CTGGGCTCCC

751 CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT GCTTGAGCCA

801 ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG GCCCTGGAAG

851 GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC

901 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC

951 CCCTGCCCTG CAGCCCTAAT AA SEQ ID NO:38

pMON31114

1 ATGGCTAACT GCTCTAACAT GATCGATGAA ATCATCACCC ACCTGAAGCA

51 GCCACCGCTG CCGCTGCTGG ACTTCAACAA CCTCAATGGT GAAGACCAAG

101 ATATCCTGAT GGAAAATAAC CTTCGTCGTC CAAACCTCGA GGCATTCAAC

151 CGTGCTGTCA AGTCTCTGCA GAATGCATCA GCAATTGAGA GCATTCTTAA

201 AAATCTCCTG CCATGTCTGC CCCTGGCCAC GGCCGCACCC ACGCGACATC

251 CAATCATCAT CCGTGACGGT GACTGGAATG AATTCCGTCG TAAACTGACC

301 TTCTATCTGA AAACCTTGGA GAACGCGCAG GCTCAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTACCCAG

451 GGTGCCATGC CGGCCTTCGC CTCTGCTTTC CAGCGCCGGG CAGGAGGGGT

501 CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG TACCGCGTTC

551 TACGCCACCT TGCGCAGCCC TCTGGCGGCT CTGGCGGCTC TCAGAGCTTC

601 CTGCTCAAGT CTTTAGAGCA AGTGAGAAAG ATCCAGGGCG ATGGCGCAGC

651 GCTCCAGGAG AAGCTGTGTG CCACCTACAA GCTGTGCCAC CCCGAGGAGC

701 TGGTGCTGCT CGGACACTCT CTGGGCATCC CCTGGGCTCC CCTGAGCTCC

751 TGCCCCAGCC AGGCCCTGCA GCTGGCAGGC TGCTTGAGCC AACTCCATAG

801 CGGCCTTTTC CTCTACCAGG GGCTCCTGCA GGCCCTGGAA GGGATATCCC

851 CCGAGTTGGG TCCCACCTTG GACACACTGC AGCTGGACGT CGCCGACTTT

901 GCCACCACCA TCTGGCAGCA GATGGAAGAA CTGGGAATGG CCCCTGCCCT

951 GCAGCCCTAA TAA SEQ ID NO:39

pMON31115

1 ATGGCTAACT GCTCTAACAT GATCGATGAA ATCATCACCC ACCTGAAGCA

51 GCCACCGCTG CCGCTGCTGG ACTTCAACAA CCTCAATGGT GAAGACCAAG

101 ATATCCTAAT GGACAATAAC CTTCGTCGTC CAAACCTCGA GGCATTCAAC

151 CGTGCTGTCA AGTCTCTGCA GAATGCATCA GCAATTGAGA GCATTCTTAA

201 AAATCTCCTG CCATGTCTGC CGCTAGCCAC GGCCGCACCC ACGCGACATC

251 CAATCCATAT CAAGGACGGT GACTGGAATG AATTCCGTCG TAAACTGACC

301 TTCTATCTGA AAACCTTGGA GAACGCGCAG GCTCAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTACCCAG

451 GGTGCCATGC CGGCCTTCGC CTCTGCTTTC CAGCGCCGGG CAGGAGGGGT

501 CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG TACCGCGTTC

551 TACGCCACCT TGCGCAGCCC ACACCATTGG GCCCTGCCAG CTCCCTGCCC

601 CAGAGCTTCC TGCTCAAGTC TTTAGAGCAA GTGAGAAAGA TCCAGGGCGA

651 TGGCGCAGCG CTCCAGGAGA AGCTGTGTGC CACCTACAAG CTGTGCCACC

701 CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC CTGGGCTCCC

751 CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT GCTTGAGCCA

801 ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG GCCCTGGAAG

851 GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC

901 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC

951 CCCTGCCCTG CAGCCCTAAT AA SEQ ID NO:40

pMON28505

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCT TGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCT GGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCT GGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGA CCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTT CCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACATGGCGTCTCCCGCTCCG CCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCC AGTGCCCA SEQ ID NO:41

pMON28506

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTT TAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTT CTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGC TTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGG CAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTG CGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACATGGCGTCTCCCG CTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACT GAGCCAGTGCCCAGAGGTTCACCCT SEQ ID NO:42

pMON28507

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGG AGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGG ACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGG GCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATG CCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCAC CCTCTGCGTCAGGGAATTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTC AGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGC CTACACCT SEQ ID NO:43

pMON28508

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGG CACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACC CACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGC CTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGA GCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAG GGAATTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTT CGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCC TGCTGCCT SEQ ID NO:44

pMON28509

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGC AGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAA CCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGACTTTAGCTTGGGAGAATGGAAAACC CAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAG CACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCT CCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGAT CCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAG GGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCG AGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCAC CCTTTGCCTACACCTGTCCTGCTGCCTGCTGTG SEQ ID NO:45

pMON28510

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGT GGAGGCTCCCCGGGGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCA TAAACTCCAAACATGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGAGCAGT GACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCTCTCATCCCTCCTGG GGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGGCCTCCTTGGAACCCAGCTTCCTCCA CAGGGCAGGACCACAGCTCACAAGGATCCCAATGCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAA GGTGCGTTTCCTGATGCTTGTAGGGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACATGGCGTCTC CCGCTCCGCCTGCTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCA TGTCCTTCACAGCAGACTGACCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTG TGGACTTTAGTTG SEQ ID NO:46

pMON28511

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTC TCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAA GGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTA GGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACC TCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGT TCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATG GAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGG GACAACTG SEQ ID NO:47

pMON28512

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAG GTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACA GTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCT CCGTCTAAAGAATCTCATAAATCTCCAAACATGGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTC ACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCT TGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGT GACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAG AGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCA GATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCA CGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCC TTGGGGCCCTGCAGAGCCTCCTT SEQ ID NO:48

pMON28513

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAAC ACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGG CGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCC CATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTG CTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTC TGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTC ATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACC CAGCTTCCTCCACAG SEQ ID NO:49

pMON28514

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAG GAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACATGGC GTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCAC AGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTA GCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCT GCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTT TCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCA GGACCACA SEQ ID NO:50

pMON28515

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGA CTTCCAAACCTGGAGAGCTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTC TTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGC AGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAA CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTC CTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCT GCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGC AACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATG TCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGT GGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTG ACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGG GGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCC ACAGGGCAGGACCACAGCTCACAAG SEQ ID NO:51

pMON28516

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGA TGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACATGGCGTCTC CCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAG ACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTG GGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGG AGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGG ACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACC ACAGCTCACAAGGATCCCAAT SEQ ID NO:52

pMON28519

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCT TGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCT GGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCT GGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGA CCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTT CCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCAACATGGCGTCTCCCGCTCCGCCT GCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGT GCCCA SEQ ID NO:53

pMON28520

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGA AAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGAT GGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGT CTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACA AGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGT AGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTC CGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTC ACCCT SEQ ID NO:54

pMON28521

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCT CCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGA ATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAG TGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTC CGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCA CAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTG TAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTC CGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTC ACCCTTTGCCTACACCT SEQ ID NO:55

pMON28522

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGG CACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACC CACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGC CTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGA GCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAG GGAATTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGT GACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTT TGCCTACACCTGTCCTGCTGCCT SEQ ID NO:56

pMON28523

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGG ACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTG CCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTT GGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCC AACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATT CGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCC CATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTG CTGTG SEQ ID NO:57

pMON28524

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCA GGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACA GTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCT CCGTCTAAAGAATCTCATAAATCTCCAAACATGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCAC AGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCAC TTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTC CTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCT TCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGA ATTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGAC TCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGC CTGCTGTGGACTTTAGCTTG SEQ ID NO:58

pMON28525

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTC TCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAA GGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTA GGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGA CCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAG GTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGA TGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACG GGGACAACTG SEQ ID NO:59

pMON28526

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATG CCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCAC CCTCTGCGTCAGGGAATTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGT AAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTA CACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGC ACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCC ACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCC TCCTT SEQ ID NO:60

pMON28527

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAA ACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGA GGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATC ATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGC AGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAA CCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGGCAGGACCACAGCTCACAAGGATCCC AATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGT CCACCCTCTGCGTCAGGGAATTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCT CAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTG CCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCA AGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGG ACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAG AGCCTCCTTGGAACCCAGCTTCCTCCACAG SEQ ID NO:61

pMON28528

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAG GAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATT CGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCC CATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTG CTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGC AGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTC CTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTC CTCCACAGGGCAGGACCACA SEQ ID NO:62

pMON28529

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTG CGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCAACATGGCGTCTCCCGCTC CGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAG CCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAA TGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAG TGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGT CCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCT CACAAG SEQ ID NO:63

pMON28530

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGA TGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTG TGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCA GAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCC AGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGC ACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTC CTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATC CCAAT SEQ ID NO:64

pMON28533

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTGACTTCCAAACCTGGAGAGC TTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATGAGGCAATTCTTCGTAATCTCCAACCATG TCTGCCCTCTGCCACGGCCGCACCCTCTCGCATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCC GGGAAAAACTGACGTTCTATTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGA GGCTCCCCGGTAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCT CCGTCTAAAGAATCTCATAAATCTCCAAACATGGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTG CTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGC AGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTC CTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTC CTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCG AGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGGC GGCAACATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCC ATGTCCTTCACAGCAGACTGAGCCAGTGCCCA SEQ ID NO:65

pMON28534

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGG AAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGA TGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCG TCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCAC AAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTG TAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGGCGGCAACATGGCGTCCCCAGCGCCGCC TGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCT TCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCT SEQ ID NO:66

pMON28535

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGG AGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGG GACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGG GGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAAT GCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCA CCCTCTGCGTCAGGGAATTCGGCGGCAACGGCGGCAACATGGCGTCCCCAGCGCCGCCTGCTTGTGACCT CCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTT CACCCTTTGCCTACACCT SEQ ID NO:67

pMON28536

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGG CAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACA ACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCT CCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCC AGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGC ACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTC CTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATC CCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGG GTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGGCGGCAACATGGCGTCCCCAGCGCCGCCTGCTTGT GACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAG AGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCT SEQ ID NO:68

pMON28537

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCG GTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATC TCATAAATCTCCAAACATGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAG GACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTT GCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCT TGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTG AGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCA GGGAATTCGGCGGCAACGGCGGCAACATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAG TAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCT ACACCTGTCCTGCTGCCTGCTGTG SEQ ID NO:69

pMON28538

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAG CAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCT CCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTT CCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCC GAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGG CGGCAACATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCC CATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTG CTGTGGACTTTAGCTTG SEQ ID NO:70

pMON28539

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTC GACTTCCAAACCTGGAGAGCTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAAT TCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAG GCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAAC AACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTC TCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAG CTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGG GCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGT GCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGGCGGCAACATG GCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTC ACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTT TAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTT CTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTG SEQ ID NO:71

pMON28540

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATG CCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGC TTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGGCGGCAACATGGCGTCCCCAGCGCC GCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGC CAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAAT GGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGT GATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTC CGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTT SEQ ID NO:72

pMON28541

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAAC ACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGG CGGCAACGGCGGCAACATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTT CGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCC TGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACAT TCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTC TCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAA CCCAGCTTCCTCCACAG SEQ ID NO:73

pMON28542

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAG GAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGGCGG CAACATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCAT GTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTG TGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGT GACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTG GGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTC CACAGGGCAGGACCACA SEQ ID NO:74

pMON28543

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCG TCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGATCCCAATGCCATCTTCCTGAGCTTCCAAC ACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGG CGGCAACGGCGGCAACATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTT CGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCC TGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACAT TCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTC TCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAA CCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAG SEQ ID NO:75

pMON28544

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGA TGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGGCGGCAACATGGCGTCCCCAGC GCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTG AGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAG AATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGG AGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAG GTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAG CTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAAT SEQ ID NO:76

pMON28545

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGC GTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACATGGCGTCTCCCGC TCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTG AGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAG AATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGG AGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAG GTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGGGCAGGACCACAGCTCACAAG SEQ ID NO:77

pMON15981

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGATCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GTCTTACAAG

451 CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC

501 CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT

551 GCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG

601 GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA

651 GCTGGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC

701 TGGGAATGGC CCCTGCCCTG CAGCCCACCC AGGGTGCCAT GCCGGCCTTC

751 GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGTTG CTAGCCATCT

801 GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC

851 CCGGCGGCGG CTCTGACATG GCTACACCAT TAGGCCCTGC CAGCTCCCTG

901 CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG CAAGTGAGGA AGATCCAGGG

951 CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAA TAA; SEQ ID NO:78

pMON15982

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGATCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GTCTCCCGAG

451 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC

501 CACCATCTGG CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC

551 CCACCCAGGG TGCCATGCCG GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA

601 GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGCTTCCTGG AGGTGTCGTA

651 CCGCGTTCTA CGCCACCTTG CGCAGCCCGG CGGCGGCTCT GACATGGCTA

701 CACCATTAGG CCCTGCCAGC TCCCTGCCCC AGAGCTTCCT GCTCAAGTCT

751 TTAGAGCAAG TGAGGAAGAT CCAGGGCGAT GGCGCAGCGC TCCAGGAGAA

801 GCTGTGTGCC ACCTACAAGC TGTGCCACCC CGAGGAGCTG GTGCTGCTCG

851 GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CCCCAGCCAG

901 GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA CTCCATAGCG GCCTTTTCCT

951 CTACCAGGGG CTCCTGCAGG CCCTGGAAGG GATATCCTAA TAA; SEQ ID NO:79

pMON15965

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGATCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GTCTTCTGCT

451 TTCCAGCGCC GGGCAGGAGG GGTCCTGGTT GCTAGCCATC TGCAGAGCTT

501 CCTGGAGGTG TCGTACCGCG TTCTACGCCA CCTTGCGCAG CCCGGCGGCG

551 GCTCTGACAT GGCTACACCA TTAGGCCCTG CCAGCTCCCT GCCCCAGAGC

601 TTCCTGCTCA AGTCTTTAGA GCAAGTGAGG AAGATCCAGG GCGATGGCGC

651 AGCGCTCCAG GAGAAGCTGT GTGCCACCTA CAAGCTGTGC CACCCCGAGG

701 AGCTGGTGCT GCTCGGACAC TCTCTGGGCA TCCCCTGGGC TCCCCTGAGC

751 TCCTGCCCCA GCCAGGCCCT GCAGCTGGCA GGCTGCTTGA GCCAACTCCA

801 TAGCGGCCTT TTCCTCTACC AGGGGCTCCT GCAGGCCCTG GAAGGGATAT

851 CCCCCGAGTT GGGTCCCACC TTGGACACAC TGCAGCTGGA CGTCGCCGAC

901 TTTGCCACCA CCATCTGGCA GCAGATGGAA GAACTGGGAA TGGCCCCTGC

951 CCTGCAGCCC ACCCAGGGTG CCATGCCGGC CTTCGCCTAA TAA SEQ ID NO:80

pMON15966

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGATCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GTCTATGGCC

451 CCTGCCCTGC AGCCCACCCA GGGTGCCATG CCGGCCTTCG CCTCTGCTTT

501 CCAGCGCCGG GCAGGAGGGG TCCTGGTTGC TAGCCATCTG CAGAGCTTCC

551 TGGAGGTGTC GTACCGCGTT CTACGCCACC TTGCGCAGCC CGGCGGCGGC

601 TCTGACATGG CTACACCATT AGGCCCTGCC AGCTCCCTGC CCCAGAGCTT

651 CCTGCTCAAG TCTTTAGAGC AAGTGAGGAA GATCCAGGGC GATGGCGCAG

701 CGCTCCAGGA GAAGCTGTGT GCCACCTACA AGCTGTGCCA CCCCGAGGAG

751 CTGGTGCTGC TCGGACACTC TCTGGGCATC CCCTGGGCTC CCCTGAGCTC

801 CTGCCCCAGC CAGGCCCTGC AGCTGGCAGG CTGCTTGAGC CAACTCCATA

851 GCGGCCTTTT CCTCTACCAG GGGCTCCTGC AGGCCCTGGA AGGGATATCC

901 CCCGAGTTGG GTCCCACCTT GGACACACTG CAGCTGGACG TCGCCGACTT

951 TGCCACCACC ATCTGGCAGC AGATGGAAGA ACTGGGATAA TAA SEQ ID NO:81

pMON15967

1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG

51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT

101 CTATCCTGAT GGATCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC

251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG

301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG

351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC

401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GTCTACCCAG

451 GGTGCCATGC CGGCCTTCGC CTCTGCTTTC CAGCGCCGGG CAGGAGGGGT

501 CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG TACCGCGTTC

551 TACGCCACCT TGCGCAGCCC GGCGGCGGCT CTGACATGGC TACACCATTA

601 GGCCCTGCCA GCTCCCTGCC CCAGAGCTTC CTGCTCAAGT CTTTAGAGCA

651 AGTGAGGAAG ATCCAGGGCG ATGGCGCAGC GCTCCAGGAG AAGCTGTGTG

701 CCACCTACAA GCTGTGCCAC CCCGAGGAGC TGGTGCTGCT CGGACACTCT

751 CTGGGCATCC CCTGGGCTCC CCTGAGCTCC TGCCCCAGCC AGGCCCTGCA

801 GCTGGCAGGC TGCTTGAGCC AACTCCATAG CGGCCTTTTC CTCTACCAGG

851 GGCTCCTGCA GGCCCTGGAA GGGATATCCC CCGAGTTGGG TCCCACCTTG

901 GACACACTGC AGCTGGACGT CGCCGACTTT GCCACCACCA TCTGGCAGCA

951 GATGGAAGAA CTGGGAATGG CCCCTGCCCT GCAGCCCTAA TAA SEQ ID NO:82

pMON15960

1 ATGGCTACAC CATTGGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT

51 CAAGTCTTTA GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC

101 AGGAGAAGCT GTGTGCCACC TACAAGCTGT GCCACCCCGA GGAGCTGGTG

151 CTGCTCGGAC ACTCTCTGGG CATCCCCTGG GCTCCCCTGA GCTCCTGCCC

201 CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GAGCCAACTC CATAGCGGCC

251 TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT ATCCCCCGAG

301 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC

351 CACCATCTGG CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC

401 CCACCCAGGG TGCCATGCCG GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA

451 GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGCTTCCTGG AGGTGTCGTA

501 CCGCGTTCTA CGCCACCTTG CGCAGCCCGG CGGCGGCTCT GACATGGCTA

551 CACCATTGGG CCCTGCCAGC TCCCTGCCCC AGAGCTTCCT GCTCAAGTCT

601 TTAGAGCAAG TGAGGAAGAT CCAGGGCGAT GGCGCAGCGC TCCAGGAGAA

651 GCTGTGTGCC ACCTACAAGC TGTGCCACCC CGAGGAGCTG GTGCTGCTCG

701 GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CCCCAGCCAG

751 GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA CTCCATAGCG GCCTTTTCCT

801 CTACCAGGGG CTCCTGCAGG CCCTGGAAGG GATATCCCCC GAGTTGGGTC

851 CCACCTTGGA CACACTGCAG CTGGACGTCG CCGACTTTGC CACCACCATC

901 TGGCAGCAGA TGGAAGAACT GGGAATGGCC CCTGCCCTGC AGCCCACCCA

1001 TCCTGGTTGC TAGCCATCTG CAGAGCTTCC TGGAGGTGTC GTACCGCGTT

1051 CTACGCCACC TTGCGCAGCC CTGATAA SEQ ID NO:83

PMON32132

TCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACA GCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAG CTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTG CTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTT CTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAG GACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGT TTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGG SEQ ID NO:84

PMON32133

TCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACA GCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAG CTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTG CTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTT CTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGGGCAGGACCACAGCTCA CAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTT GTAGGAGGGTCCACCCTCTGCGTCAGG SEQ ID NO:85

pMON32134

TCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACA GCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAG CTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTC TGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCA TCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCC AGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCT GCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGG SEQ ID NO:86

Pmon13181

1 CCATGGCTAA CTGCTCTATA ATGATCGATG AAATTATACA TCACTTAAAG

51 AGACCACCTG CACCTTTGCT GGACCCGAAC AACCTCAATG ACGAAGACGT

101 CTCTATCCTG ATGGATCGAA ACCTTCGACT TCCAAACCTG GAGAGCTTCG

151 TAAGGGCTGT CAAGAACTTA GAAAATGCAT CAGGTATTGA GGCAATTCTT

201 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA

251 TCCAATCATC ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA

301 CGTTCTATCT GGTTACCCTT GAGCAAGCGC AGGAACAACA GTACGTAgag

351 ggcggtggag gctcCCCGGG TGAACCGTCT GGTCCAATCT CTACTATCAA

401 CCCGTCTCCT CCGTCTAAAG AATCTCATAA ATCTCCAAAC ATGTAAGGTA

451 CCGCATGCAA GCTT SEQ ID NO:87

Pmon13180.Seg

1 CCATGGCTAA CTGCTCTATA ATGATCGATG AAATTATACA TCACTTAAAG

51 AGACCACCTG CACCTTTGCT GGACCCGAAC AACCTCAATG ACGAAGACGT

101 CTCTATCCTG ATGGATCGAA ACCTTCGACT TCCAAACCTG GAGAGCTTCG

151 TAAGGGCTGT CAAGAACTTA GAAAATGCAT CAGGTATTGA GGCAATTCTT

201 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA

251 TCCAATCATC ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA

301 CGTTCTATCT GGTTACCCTT GAGCAAGCGC AGGAACAACA GTACGTAgag

351 ggcggtggag gctcCCCGGG TGGTGGTTCT GGCGGCGGCT CCAACATGTA

401 AGGTACCGCA TGCAAGCTT SEQ ID NO:88

pMON30237.seq

GCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGC

TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA

CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGCGCTCTGGCGG

CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC

CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA

CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC

AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA

GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC

AGCCC SEQ ID NO:89

pMON30238.seq

GCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGC

TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA

CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG

CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC

CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA

CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC

AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA

GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC

AGCCCGACTCCTCAACCCTG SEQ ID NO:90

pMON30239.seq

GCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGC

TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA

CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG

CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC

CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA

CCAAATGTGCCTTTCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA

GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC

AGCCCGACTCCTCAACCCTG SEQ ID NO:91

pMON32329.seq

GGAACTCAGGATTGTTCTTTCCAACACAGCCCCATCTCCTCCGACTTCGC

TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA

CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG

CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC

CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA

CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC

AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA

GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC

AGCCC SEQ ID NO:92

pMON32330.seq

GGTACCCAGGATTGTTCTTTCCAACACAGCCCCATCTCCTCCGACTTCGC

TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA

CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG

CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC

CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA

CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC

AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA

GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC

AGCCCGACTCCTCAACCCTG SEQ ID NO:93

MON32341.seq

GCCACTCAGGACTGTTCTTTCCAACACAGCCCCATCTCCTCCGACTTCGC

TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA

CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG

CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC

CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA

CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC

AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA

GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC

AGCCC SEQ ID NO:94

pMON32342.seq

GCCACTCAGGACTGCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGC

TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA

CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG

CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC

CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA

CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC

AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA

GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC

AGCCCGACTCCTCAACCCTG SEQ ID NO:95

pMON32320.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGTCTGGAGGTAACGGATCCGGTGGCAATGGGAGCGGCGGAAATGGAAC

CCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCA

AAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG

GCCTCCAACCTGCAG SEQ ID NO:96

pMON32321.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGTCAGGCGGTAACGGCAGTGGAGGTAATGGCACCCAGGACTGCTCCTT

CCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT

CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG

SEQ ID NO:97

pMON32322.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGTCTGGCGGCAACGGCACCCAGGACTGCTCCTTCCAACACAGCCCCAT

CTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC

AAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:98

pMON32323.seq

GCCTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT

TGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCC

AGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCG

CTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA

GTGTCAGCCCGACTCCTCAACCCTGTCTGGAGGTAACGGATCCGGTGGCA

ATGGGAGCGGCGGAAATGGAACCCAGGACTGCTCCTTCCAACACAGCCCC

ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCT

TCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCT

GCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC

AAGACTGTCGCTGGG SEQ ID NO:99

pMON32324.seq

GCCTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT

TGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCC

AGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCG

CTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA

GTGTCAGCCCGACTCCTCAACCCTGTCTGGAGGTAACGGATCCGGAGGTA

ATGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTC

GCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGT

CACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGC

GGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGG

SEQ ID NO:100

pMON32325.seq

GCCTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT

TGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCC

AGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCG

CTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA

GTGTCAGCCCGACTCCTCAACCCTGTCTGGCGGCAACGGCACGCAGGACT

GCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGT

GAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAA

CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCAC

AGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGG SEQ ID NO:101

pMON32326.seq

GCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGTCTGGAGGTAACGGCAGTGGTGGCAATGGGAGCGGTGGAAATGGAAC

CCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCA

AAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG

GCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGT

CCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGA

TGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAA

TGTGCCTTTCAGCCC SEQ ID NO:102

pMON32327.seq

GCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGTCAGGCGGTAACGGCAGTGGAGGTAATGGCACCCAGGACTGCTCCTT

CCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT

CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG

GACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTG

GATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGG

AGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC

SEQ ID NO:103

pMON32328.seq

GCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGTCTGGCGGCAACGGCACGCAGGACTGCTCCTTCCAACACAGCCCCAT

CTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC

AAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGC

GGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAA

GACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGG

AGATACACTTTGTCACCAAATGTGCCTTTCAGCCC SEQ ID NO:104

pMON32348.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGTCTGGAGGTAGTGGATCCGGAGGTTCTGGCAACCCAGGACTGCTCCT

TCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTG

TCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG

SEQ ID NO:105

pMON32350.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGTCTGGAGGTAGTGGATCCGGTGGCAGTGGGAGCGGCGGATCTGGAAC

CCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCA

AAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG

GCCTCCAACCTGCAG SEQ ID NO:106

FLT3N.seq

CCATGGCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC

TTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCC

AGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCT

GGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCT

GGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT

TGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCC

AGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCG

CTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA

GTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGATCC SEQ ID NO:107

FLT3C.seq

GGATCCGGAGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTC

CGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATT

ACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGC

CTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGT

CGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATAC

ACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTC

GTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGT

GGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGC

TGCAGTGTCAGCCCGACTCCTCAACCCTGTAAGCTT SEQ ID NO:108

FLT7N.seq

CCATGGCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC

TTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCC

AGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCT

GGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCT

GGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT

TGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCC

AGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCG

CTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA

GTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCC

SEQ ID NO:109

FLT4C.seq

GGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTC

CTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAG

ATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGG

GGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGAC

TGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGA

TACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGC

TTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCT

GGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGG

AGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTAAGCTT

SEQ ID NO:110

FLT11N.seq

CCATGGCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC

TTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCC

AGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCT

GGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCT

GGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT

TGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCC

AGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCG

CTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA

GTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAG

GAGGTGGATCC SEQ ID NO:111

FLT10C.seq

GGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTT

CCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT

CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG

GACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTG

GATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGG

AGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC

CCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCA

GGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGA

ACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG

TAAGCTT SEQ ID NO:112

pMON32365.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGGGCGGTGGATCCGGAGGTACCCAGGACTGCTCCTTCCAACACAGCCC

CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC

TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:113

pMON32366.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGGGCGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAG

CCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACC

TGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:114

pMON32367.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTACCCAGGACTGCTCCTT

CCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT

CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG

SEQ ID NO:115

pMON32368.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGGGCGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGA

CTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCC

GTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC

AACCTGCAG SEQ ID NO:116

pMON32369.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCAC

CCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCA

AAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG

GCCTCCAACCTGCAG SEQ ID NO:117

pMON32370.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCCCCCCCCAGCTGCCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT

GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC

AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC

CTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTC

AGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCT

CCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAA

GATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:118

pMON30247.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCCAGGAC

TGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCG

TGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCA

ACCTGCAGGACGAGGAGCTCTGCGGGGCGCTCTGGCGGCTGGTCCTGGCA

CAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGG

CTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCT

TTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC

CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCAC

TCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC SEQ ID NO:119

pMON30248.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCCAGGAC

TGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCG

TGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCA

ACCTGCAGGACGAGGAGCTCTGCGGGGCGCTCTGGCGGCTGGTCCTGGCA

CAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGG

CTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCT

TTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC

CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCAC

TCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCT

CAACCCTG SEQ ID NO:120

pMON32332.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCAGGCGGT

AACGGCAGTGGAGGTAATGGCACCCAGGACTGCTCCTTCCAACACAGCCC

CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC

TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:121

pMON32333.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCTGGAGGT

AACGGATCCGGTGGCAATGGGAGCGGCGGAAATGGAACCCAGGACTGCTC

CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC

TGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG

CAG SEQ ID NO:122

pMON32334.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGTCTGGCGGCAACGGCACGCAGGACTGCTCCTTCCAAC

ACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGAC

TACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGA

GGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGG

AGCGGCTCAAGACTGTCGCTGGG SEQ ID NO:123

pMON32335.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGTCTGGAGGTAACGGATCCGGAGGTAATGGCACCCAGG

ACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC

CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTC

CAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGG

CACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGG SEQ ID NO:124

pMON32336.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGTCTGGAGGTAACGGATCCGGTGGCAATGGGAGCGGCG

GAAATGGAACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC

TTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCC

AGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCT

GGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCT

GGG SEQ ID NO:125

MON32337.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCTGGCGGC

AACGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTT

CGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAG

TCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGG

CGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGG

GTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTG

TCACCAAATGTGCCTTTCAGCCC SEQ ID NO:126

pMON32338.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCAGGCGGT

AACGGCAGTGGAGGTAATGGCACCCAGGACTGCTCCTTCCAACACAGCCC

CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC

TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTC

TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCT

CAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACA

CGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC SEQ ID NO:127

pMON32339.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCTGGAGGT

AACGGCAGTGGTGGTAATGGGAGCGGCGGAAATGGAACCCAGGACTGCTC

CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC

TGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG

CAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCC SEQ ID NO:128

pMON32364.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCGACTCAGGAC

TGTTCTTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCG

TGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCA

ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCA

CAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGG

CTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCT

TTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC

CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCAC

TCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC SEQ ID NO:129

pMON32377.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCAACCCAGGAC

TGCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCG

TGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCA

ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCA

CAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGG

CTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCT

TTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC

CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCAC

TCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCT

CAACCCTG SEQ ID NO:130

MON32392.seq

GCCACTCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGC

TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA

CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG

CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC

CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA

CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC

AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA

GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC

AGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA

ATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC

AAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAA

AGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGAC

ATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATT

CGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTC

TTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGA

CATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACT

GACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:131

pMON32352.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCCAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCAGGCGGT

AACGGCAGTGGAGGTAATGGCACCCAGGACTGCTCCTTCCAACACAGCCC

CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC

TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:132

pMON32353.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCTGGAGGT

AACGGATCCGGTGGCAATGGGAGCGGCGGAAATGGAACCCAGGACTGCTC

CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC

TGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG

CAG SEQ ID NO:133

pMON32354.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGTCTGGCGGCAACGGCACGCAGGACTGCTCCTTCCAAC

ACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGAC

TACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGA

GGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGG

AGCGGCTCAAGACTGTCGCTGGG SEQ ID NO:134

pMON32355.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGTCTGGAGGTAACGGATCCGGAGGTAATGGCACCCAGG

ACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC

CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTC

CAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGG

CACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGG SEQ ID NO:135

pMON32356.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGTCTGGAGGTAACGGATCCGGTGGCAATGGGAGCGGCG

GAAATGGAACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC

TTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCC

AGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCT

GGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCT

GGG SEQ ID NO:136

pMON32357.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCTGGCGGC

AACGGCACGCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTT

CGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAG

TCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGG

CGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGG

GTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTG

TCACCAAATGTGCCTTTCAGCCC SEQ ID NO:137

pMON32358.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCAGGCGGT

AACGGCAGTGGAGGTAATGGCACCCAGGACTGCTCCTTCCAACACAGCCC

CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC

TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTC

TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCT

CAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACA

CGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC SEQ ID NO:138

pMON32359.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCTGGAGGT

AACGGCAGTGGTGGCAATGGGAGCGGCGGAAATGGAACCCAGGACTGCTC

CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC

TGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG

CAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCC SEQ ID NO:139

pMON32360.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCCAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCTGGAGGT

AGTGGATCCGGAGGTTCTGGCACCCAGGACTGCTCCTTCCAACACAGCCC

CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC

TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:140

pMON32362.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCTGGAGGT

AGTGGATCCGGTGGCAGTGGGAGCGGCGGATCTGGAACCCAGGACTGCTC

CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC

TGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG

CAG SEQ ID NO:141

MON32393.seq

GCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGC

TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA

CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG

CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC

CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA

CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC

AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA

GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC

AGCCCGACTCCTCAACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGT

GAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGA

ATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAA

TTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAAC

CTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCC

AAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAG

GTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACG

GCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGA

ATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGG

AACAACAG SEQ ID NO:142

MON32371.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGA

TCCGGAGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGA

CTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACC

CAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:143

pMON32372.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGA

TCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTC

CGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATT

ACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:144

pMON32373.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGG

TCAGGAGGTGGATCCGGAGGTACCCAGGACTGCTCCTTCCAACACAGCCC

CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC

TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:145

pMON32374.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGA

TCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCA

ACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTG

ACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:146

pMON32375.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGG

TCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTC

CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC

TGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG

CAG SEQ ID NO:147

pMON32376.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGG

TCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAG

TGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCG

CTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTC

ACCGTGGCCTCCAACCTGCAG SEQ ID NO:148

pMON32378.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGGGCGGTGGATCCGGAGGTACCCAGGACTGCTCCTTCC

AACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCT

GACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGA

CGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGA

TGGAGCGGCTCAAGACTGTCGCTGGG SEQ ID NO:149

pMON32379.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCT

TCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTG

TCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCA

GGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCT

GGATGGAGCGGCTCAAGACTGTCGCTGGG SEQ ID NO:150

pMON32380.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTACCCAGG

ACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC

CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTC

CAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGG

CACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGG SEQ ID NO:151

pMON32381.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTG

GTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCT

GTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCAC

CGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGC

TGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGG SEQ ID NO:152

pMON32382.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCG

GAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC

TTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCC

AGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCT

GGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCT

GGG SEQ ID NO:153

pMON32383.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCG

GAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACAC

AGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTA

CCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGG

AGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAG

CGGCTCAAGACTGTCGCTGGG SEQ ID NO:154

pMON32384.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGA

TCCGGAGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGA

CTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACC

CAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTC

TGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGC

TGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACT

TTGTCACCAAATGTGCCTTTCAGCCC SEQ ID NO:155

pMON32385.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGA

TCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTC

CGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATT

ACCCAGTCACCGTGGCCTCCAACCTGCAGGATGAGGAGCTCTGCGGGGGC

CTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGT

CGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATAC

ACTTTGTCACCAAATGTGCCTTTCAGCCC SEQ ID NO:156

pMON32386.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGG

TCAGGAGGTGGATCCGGAGGTACCCAGGACTGCTCCTTCCAACACAGCCC

CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC

TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTC

TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCT

CAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACA

CGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC SEQ ID NO:157

pMON32387.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGA

TCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCA

ACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTG

ACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGAC

GAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGAT

GGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGC

GCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC SEQ ID NO:158

pMON32388.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGG

TCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTC

CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC

TGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG

CAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCC SEQ ID NO:159

pMON32389.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGG

TCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAG

TGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCG

CTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTC

ACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCG

GCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGT

CCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC

ACCAAATGTGCCTTTCAGCCC SEQ ID NO:160

hflt3-2829link10.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGATTACCCA

GTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTG

GCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG

GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT

GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCA

GACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGC

TGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG

TGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGG

AGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCG

CTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAA SEQ ID NO:161

hflt3-2829link15.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGATTACCCA

GTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTG

GCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG

GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT

GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCA

GACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGC

TGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG

TGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGG

AGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCA

TCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTT

CAA SEQ ID NO:162

hflt3-3435link10.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGCCTCCAAC

CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA

GCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCT

TGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTT

CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCT

CCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC

GCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA

ACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTACCCAGGACTGCTC

CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC

TGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG SEQ ID NO:163

hflt3-3435link15.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAAGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGCCTCCAAC

CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA

GCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCT

TGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTT

CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCT

CCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC

GCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA

ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGG

CACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTG

TCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACC

GTG SEQ ID NO:164

hflt3-6263link10.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGTCGCTGGG

TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT

CACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA

CCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG

AAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTG

TCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAG

GTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCT

GTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCAC

CGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGC

TGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACT SEQ ID NO:165

hflt3-6263link15.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGTCGCTGGG

TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT

CACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA

CCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG

AAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTG

TCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAG

GTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATC

TCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCA

AGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCG

GGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAG

ACT SEQ ID NO:166

hflt3-9495link10.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCGCTTCGTC

CAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGC

GCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC

AGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCC

GGAGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTT

CGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAG

TCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGG

CGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGG

GTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTG

TCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTT SEQ ID NO:167

hflt3-9495link15.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCGCTTCGTC

CAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGC

GCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC

AGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCA

GGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCC

CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC

TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTC

TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCT

CAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACA

CGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGT

CTT SEQ ID NO:168

hflt3-9899link10.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAAGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCAACATC

TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTG

GATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG

ACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTACCCAG

GACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAAT

CCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCT

CCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTG

GCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCA

AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTG

CCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAG SEQ ID NO:169

hflt3-9899link15.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCAACATC

TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTG

GATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG

ACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCC

GGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGA

CTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACC

CAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTC

TGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGC

TGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACT

TTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTC

CAG SEQ ID NO:170

hflt3-2829link6.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGATTACCCA

GTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTG

GCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG

GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT

GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCA

GACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGC

TGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG

TGTCAGCCCGACTCCTCAACCCTGGGCGGTGGATCCGGAGGTACCCAGGA

CTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCC

GTGAGCTGTCTGACTACCTGCTTCAA SEQ ID NO:171

hflt3-2829link7.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGATTACCCA

GTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTG

GCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG

GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT

GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCA

GACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGC

TGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG

TGTCAGCCCGACTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCACCCA

GGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAA

TCCGTGAGCTGTCTGACTACCTGCTTCAA SEQ ID NO:172

hflt3-2829link13.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGATTACCCA

GTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTG

GCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG

GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT

GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCA

GACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGC

TGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG

TGTCAGCCCGACTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCTCAGG

GGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCT

CCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAA SEQ ID NO:173

hflt3-2829link21.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGATTACCCA

GTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTG

GCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG

GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT

GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCA

GACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGC

TGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG

TGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGG

AGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCT

CCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAG

CTGTCTGACTACCTGCTTCAA SEQ ID NO:174

hflt3-3435link6.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGCCTCCAAC

CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA

GCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCT

TGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTT

CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCT

CCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC

GCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA

ACCCTGGGCGGTGGATCCGGAGGTACTGCTCCTTCCAACACAGCCCCATC

TCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCA

AGATTACCCAGTCACCGTG SEQ ID NO:175

hflt3-3435link7.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGCCTCCAAC

CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA

GCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCT

TGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTT

CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCT

CCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC

GCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA

ACCCTGGGCGGTGGATCCGGAGGTGGCACTGCTCCTTCCAACACAGCCCC

ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCT

TCAAGATTACCCAGTCACCGTG SEQ ID NO:176

hflt3-3435link13.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGCCTCCAAC

CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA

GCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCT

TGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTT

CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCT

CCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC

GCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA

ACCCTGGGCGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACTGC

TCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGA

GCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG SEQ ID NO:177

hflt3-3435link21.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGCCTCCAAC

CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA

GCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCT

TGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTT

CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCT

CCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC

GCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA

ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGG

CTCAGGGGGAGGTAGTGGTAGGACTGCTCCTTCCAACACAGCCCCATCTC

CTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAG

ATTACCCAGTCACCGTG SEQ ID NO:178

hflt3-6263link6.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGTCGCTGGG

TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT

CACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA

CCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG

AAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTG

TCAGCCCGACTCCTCAACCCTGGGCGGTGGATCCGGAGGTACCCAGGACT

GCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGT

GAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAA

CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCAC

AGCGCTGGATGGAGCGGCTCAAGACT SEQ ID NO:179

hflt3-6263link7.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGTCGCTGGG

TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT

CACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA

CCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG

AAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTG

TCAGCCCGACTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCACCCAGG

ACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC

CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTC

CAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGG

CACAGCGCTGGATGGAGCGGCTCAAGACT SEQ ID NO:180

hflt3-6263link13.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGTCGCTGGG

TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT

CACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA

CCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG

AAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTG

TCAGCCCGACTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCTCAGGGG

GAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCC

GACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTA

CCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCC

TCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACT SEQ ID NO:181

hflt3-6263link21.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGTCGCTGGG

TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT

CACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA

CCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG

AAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTG

TCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAG

GTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCC

TTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCT

GTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGC

AGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGC

TGGATGGAGCGGCTCAAGACT SEQ ID NO:182

hflt3-9495link6.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCGCTTCGTC

CAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGC

GCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC

AGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGATCCGGAGGTACCCAG

GACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAAT

CCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCT

CCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTG

GCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCA

AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTG

CCTTTCAGCCCCCCCCCAGCTGTCTT SEQ ID NO:183

hflt3-9495link7.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCGCTTCGTC

CAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGC

GCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC

AGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCACC

CAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAA

AATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGG

CCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTC

CTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGAT

GCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAAT

GTGCCTTTCAGCCCCCCCCCAGCTGTCTT SEQ ID NO:184

hflt3-9495link13.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCGCTTCGTC

CAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGC

GCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC

AGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCTCA

GGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTC

CTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAG

ATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGG

GGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGAC

TGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGA

TACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTT SEQ ID NO:185

hflt3-9495link21.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCGCTTCGTC

CAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGC

GCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC

AGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCA

GGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTG

CTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTG

AGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAAC

CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA

GCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCT

TGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTT

CAGCCCCCCCCCAGCTGTCTT SEQ ID NO:186

hflt3-9899link6.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAAGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCAACATC

TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTG

GATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG

ACTCCTCAACCCTGGGCGGTGGATCCGGAGGTACCCAGGACTGCTCCTTC

CAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTC

TGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGG

ACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGG

ATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGA

GCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCC

CCCCCAGCTGTCTTCGCTTCGTCCAG SEQ ID NO:187

hflt3-9899link7.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAAGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCAACATC

TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTG

GATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG

ACTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCACCCAGGACTGCTCC

TTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCT

GTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGC

AGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGC

TGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCT

GGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGC

CCCCCCCCAGCTGTCTTCGCTTCGTCCAG SEQ ID NO:188

hflt3-9899link13.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAAGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCAACATC

TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTG

GATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG

ACTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGT

GGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGC

TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA

CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG

CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC

CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA

CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAG SEQ ID NO:189

hflt3-9899link21.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG

GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCAACATC

TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTG

GATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG

ACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCC

GGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACA

CAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACT

ACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAG

GAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGA

GCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCG

TGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCC

AGCTGTCTTCGCTTCGTCCAG SEQ ID NO:190

pMON32390

GGATCCACCATGAGCCGCCTGCCCGTCCTGCTCCTGCTCCAACTCCTGGT

CCGCCCCGCCATGTCTACAAATCAAGATCTGCCTGTGATCAAGTGTGTTT

TAATCAATCATAAGAACAATGATTCATCAGTGGGGAAGTCATCATCATAT

CCCATGGTATCAGAATCCCCGGAAGACCTCGGGTGTGCGTTGAGACCCCA

GAGCTCAGGGACAGTGTACGAAGCTGCCGCTGTGGAAGTGGATGTATCTG

CTTCCATCACACTGCAAGTGCTGGTCGATGCCCCAGGGAACATTTCCTGT

CTCTGGGTCTTTAAGCACAGCTCCCTGAATTGCCAGCCACATTTTGATTT

ACAAAACAGAGGAGTTGTTTCCATGGTCATTTTGAAAATGACAGAAACCC

AAGCTGGAGAATACCTACTTTTTATTCAGAGTGAAGCTACCAATTACACA

ATATTGTTTACAGTGAGTATAAGAAATACCCTGCTTTACACATTAAGAAG

ACCTTACTTTAGAAAAATGGAAAACCAGGACGCCCTGGTCTGCATATCTG

AGAGCGTTCCAGAGCCGATCGTGGAATGGGTGCTTTGCGATTCACAGGGG

GAAAGCTGTAAAGAAGAAAGTCCAGCTGTTGTTAAAAAGGAGGAAAAAGT

GCTTCATGAATTATTTGGGATGGACATAAGGTGCTGTGCCAGAAATGAAC

TGGGCAGGGAATGCACCAGGCTGTTCACAATAGATCTAAATCAAACTCCT

CAGACCACATTGCCACAATTATTTCTTAAAGTAGGGGAACCCTTATGGAT

AAGGTGCAAAGCTGTTCATGTGAACCATGGATTCGGGCTCACCTGGGAAT

TAGAAAACAAAGCACTCGAGGAGGGCAACTACTTTGAGATGAGTACCTAT

TCAACAAACAGAACTATGATACGGATTCTGTTTGCTTTTGTATCATCAGT

GGCAAGAAACGACACCGGATACTACACTTGTTCCTCTTCAAAGCATCCCA

GTCAATCAGCTTTGGTTACCATCGTAGAAAAGGGATTTATAAATGCTACC

AATTCAAGTGAAGATTATGAAATTGACCAATATGAAGAGTTTTGTTTTTC

TGTCAGGTTTAAAGCCTACCCACAAATCAGATGTACGTGGACCTTCTCTC

GAAAATCATTTCCTTGTGAGCAAAAGGGTCTTGATAACGGATACAGCATA

TCCAAGTTTTGCAATCATAAGCACCAGCCAGGAGAATATATATTCCATGC

AGAAAATGATGATGCCCAATTTACCAAAATGTTCACGCTGAATATAAGAA

GGAAACCTCAAGTGCTCGCAGAAGCATCGGCAAGTCAGGCGTCCTGTTTC

TCGGATGGATACCCATTACCATCTTGGACCTGGAAGAAGTGTTCAGACAA

GTCTCCCAACTGCACAGAAGAGATCACAGAAGGAGTCTGGAATAGAAAGG

CTAACAGAAAAGTGTTTGGACAGTGGGTGTCGAGCAGTACTCTAAACATG

AGTGAAGCCATAAAAGGGTTCCTGGTCAAGTGCTGTGCATACAATTCCCT

TGGCACATCTTGTGAGACGATCCTTTTAAACTCTCCAGGCCCCTTCCCTT

TCATCCAAGACAACGAATTCATCATCCTGGGCCTGTTCGGCCTCCTGCTG

TTGCTCACCTGCCTCTGTGGAACTGCCTGGCTCTGTTGCAGCCCCAACAG

GAAGAATCCCCTCTGGCCAAGTGTCCCAGACCCAGCTCACAGCAGCCTGG

GCTCCTGGGTGCCCACAATCATGGAGGAGGATGCCTTCCAGCTGCCCGGC

CTTGGCACGCCACCCATCACCAAGCTCACAGTGCTGGAGGAGGATGAAAA

GAAGCCGGTGCCCTGGGAGTCCCATAACAGCTCAGAGACCTGTGGCCTCC

CCACTCTGGTCCAGACCTATGTGCTCCAGGGGGACCCAAGAGCAGTTTCC

ACCCAGCCCCAATCCCAGTCTGGCACCAGCGATCAGGTCCTTTATGGGCA

GCTGCTGGGCAGCCCCACAAGCCCAGGGCCAGGGCACTATCTCCGCTGTG

ACTCCACTCAGCCCCTCTTGGCGGGCCTCACCCCCAGCCCCAAGTCCTAT

GAGAACCTCTGGTTCCAGGCCAGCCCCTTGGGGACCCTGGTAACCCCAGC

CCCAAGCCAGGAGGACGACTGTGTCTTTGGGCCACTGCTCAACTTCCCCC

TCCTGCAGGGGATCCGGGTCCATGGGATGGAGGCGCTGGGGAGCTTC SEQ ID NO:191

pMON30329.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGT CGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACC CAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATC TGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGG AGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCAT AAATCTCCAAACATGGCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCA AAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGA GGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCT GGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTC AGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCA GCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC GACTCCTCAACCCTG SEQ ID NO:192

pMON32173.seq

GCCACTCAGGACTGCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGG CCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCT GTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG TACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTC CGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTC CTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCC TCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGG ATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATAC ACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCG CCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG SEQ ID NO:193

pMON32175.seq

GCCACCCAGGACTGCTCCTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGG CCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCT GTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA GCCATGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG TACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTC CGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAG CTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTG TGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGG CTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCT TTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACA CTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTG CCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCT GGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTTTACGCCACCTTGCGCAGCCC SEQ ID NO:194

pMON32204.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACC GTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCC ACTCAGGACTGCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTG ACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCT CTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGC TTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTC TTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCC CTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGT CTAAAGAATCTCATAAATCTCCAAACATGGCTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTC CGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC AACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGC TCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCAC CAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAG GAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGC TGCAGTGTCAGCCCGACTCCTCAACCCTG SEQ ID NO:195

pMON32205.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCCACTCAGGACTGCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTG TCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGA CGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTC GCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCT TTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGA GCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAG CCCGACTCCTCAACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTA CTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACCCAGGACTGCTCCTT CCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGAT TACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGG CACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAA CACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGA ACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG SEQ ID NO:196

pMON32208.seq

GCCACTCAGGACTGCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGG CCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCT GTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG TACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTC CGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAG CTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTG TGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGG CTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCT TTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACA CTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTG CCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCT GGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGT CTAAAGAATCTCATAAATCTCCAAACATGGCTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTC CGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC AACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGC TCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATA CACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCC GCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCG GTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG SEQ ID NO:197

pMON35767.seq/pMON32191.seq

GGCCACTCAGGACTGCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTG TCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGG GCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCA AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGA AGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCT GTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGGCTACACCATTG GGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCG ATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCT CGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGC TGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCC CCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCA GATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCT TTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCG TTCTACGCCACCTTGCGCAGCCG SEQ ID NO:198

pMON32397.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCG AACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATT CTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGG CAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACA ACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCT CCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGATTACCCAGTCACCGTGGCCTCCAACCTGC AGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGAC TGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGT GCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCT CCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTG TCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTACCCAGGACTGCTCCTTC CAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAA SEQ ID NO:199

pMON32398.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCCGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCG GGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGAT GCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCA GCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAG CTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG ACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTG CTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTT CAA SEQ ID NO:200

pMON32399.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATC TCATAAATCTCCAAACATGGCCGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTG GTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGC GCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGT CCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACT CGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAG GAGGTGGATCCGGAGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAA AATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG SEQ ID NO:201

pMON35700.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATT CTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGG CAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACA ACAGTACGTAGAAGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCT CCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGCCTCCAACCTGCAGGACGAGGAGCTCTGCG GGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGAT GCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCC AGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGC TGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAAC CCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAA CACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACC CAGTCACCGTG SEQ ID NO:202

pMON35701.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCCGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGA TACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTC CCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCC CGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGA TCCGGAGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTG AGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTG CGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACT SEQ ID NO:203

pMON35702.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCCGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGA TACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTC CCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCC CGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAG GTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAA AATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAG GAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACT SEQ ID NO:204

pMON35703.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATC ATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGC AGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAA CCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCGCTTCGTCCAGACCAACATCTCC CGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGG TACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCT GACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCC TCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGG CTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGT CTT SEQ ID NO:205

pMON35704.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCCCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGC AGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCC CGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGAC TGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCT GGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAG CGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTT SEQ ID NO:206

pMON35705.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAAGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCCACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGC TGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAAC CCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCC TCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCT CCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAG SEQ ID NO:207

pMON35706.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAA CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTC CTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCAACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGT CAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCC AGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTA CCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGG CGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCG CTTCGTCCAG SEQ ID NO:208

pMON35733.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCTTCTAATCTGCAAGATGAAGAGCTGTGCGGGGGCCTCTGGCGGCTGGTCC TGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGT GAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAG ACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGG TGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACAC AGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACC TGCTTCAAGATTACCCAGTCACCGTGGCC SEQ ID NO:209

pMON35734.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCCAACCTGCAAGATGAAGAGCTGTGTGGGGGCCTCTGGCGGCTGGTCCTGG CACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAA CACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGA ACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGG GTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGC CCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA CCGTGGCCTCC SEQ ID NO:210

pMON35735.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAG GCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAAC AACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTC TCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTCTGCAGGATGAGGAACTGTGCGGCGGCCTC TGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCT TGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCTTTTCAGCCCCCCCCCAGCTGTCT TCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCC TGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCG GTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTG CTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTT CAAGATTACCCAGTCACCGTGGCCTCCAAC SEQ ID NO:211

pMON35736.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCTCAAGATGAAGAGCTGTGTGGTGGTCTCTGGCGGCTGGTCCTGGCACAGC GCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGA GATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATC TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG AACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTG GGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAG CCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTC ACCGTGGCCTCCAACCTG SEQ ID NO:212

pMON35738.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCTGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGA TGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACA CTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGT GCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGG ATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCC GACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCA ACCTGCAGGAC SEQ ID NO:213

pMON35739.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGA ACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTC TTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGC AGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAA CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTC CTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTGAGCTGTGTGGTGGCCTGTGGCGTCTGGTCCT GGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTG AACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA CCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCA AAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGT GGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACA GCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGT CACCGTGGCCTCCAACCTGCAGGACGAG SEQ ID NO:214

pMON35740.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCTCTGTGCGGTGGTCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGC GGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACA CGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAA CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAAC TTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGT CAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCC CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACC GTGGCCTCCAACCTGCAGGACGAGGAG SEQ ID NO:215

pMON35741.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCTTCTAATCTGCAAGATGAAGAGCTGTGCGGGGGCCTCTGGCGGCTGGTCC TGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGT GAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAG ACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGG TGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACAC AGCCCCATCTCCTCCGACTCCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAG TCACCGTGGCC SEQ ID NO:216

pMON35742.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCTCAAGATGAAGAACTGTGCGGTGGTCTCTGGCGGCTGGTCCTGGCACAGC GCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGA GATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATC TCCCGCCTCCTGCGGGAGACCTCCGAGCAGCCGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCT CCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGG AGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATC TCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGG CCTCCAACCTG SEQ ID NO:217

pMON35743.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACC CGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC ATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCT CCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTCTGTGCGGTGGTCTGTGGCGTCTGGTCCTGG CACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAA CACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGA ACTTCTCCCGGTGCCTGGAGCTGCAGTGTCGGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGG GTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGC CCCATCTCCTCCGACTTCGCTGTCAAGATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA CCGTGGCCTCCAACCTGCAGGACGAGGAG SEQ ID NO:218

pMON32179.seq

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTC AGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGTACGTAGAGGGCGGTGGAGGCT CCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATC TCCAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCT TTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAA ACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGAC TGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAG CGCAGGAACAACAG SEQ ID NO:219

pMON35707.seq

GCGGATGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAGGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTACCCAGGACTGCTCCTT CCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGAT TACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTG GTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTG CTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAAC CTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAA GGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCC CTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAA AAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:220

pMON35708.seq

GCCGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGAAC CCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAG AGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAA ACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGA GGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATC ATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGC AGGAACAACAG SEQ ID NO:221

pMON35709.seq

GCAGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTC AGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAG AGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAA ACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGA GGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATC ATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGC AGGAACAACAG SEQ ID NO:222

pMON35710.seq

GCGGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCCTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCCTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGAAC CCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGAC TACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTG CTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACC TGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCT CCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGG CAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:223

pMON35711.seq

GCGGATGAGGAGCTGTGTGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGGGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTC AGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCC TCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCT CCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAA CCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAA ATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGG ATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGA AAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCC TCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGG TTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:224

pMON35719.seq

GGCCGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTG GTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGC GCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGT CCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACT CGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAG GAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTC CGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAATACGTAGAGGGCGGTGGAGGCTCC CCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTC CAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTT GCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAAC CTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATC TCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTG GCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGC AGGAACAACAG SEQ ID NO:225

pMON35720.seq

GCCGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGA TGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACA CTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGT GCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGG ATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTG CTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACC TGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCT CCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGG CAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:226

pMON35721.seq

GCCGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAAT GTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGAC CTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG TGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCA CCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGA CTACCTGCTTCAGGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTTACGTAGAGG GCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGA ATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGA CCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACC TTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGC AATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATC AAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGG AACAACAG SEQ ID NO:227

pMON35722.seq

GCCTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTC AGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCA GCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC GACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACT GCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCT TCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTG GTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGCTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTG CTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACC TGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCT CCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGG CAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:228

pMON35723.seq

GCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGC TGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA CTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGC TCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC AAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGT CCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGC GTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCGTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTG CTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACC TGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCT CCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGG CAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:229

pMON35725.seq

GCCACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC GCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGG AGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCC GACTTYGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCA ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCT CAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC AAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGTACGTA GAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTA AAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAA GAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGA AACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTG AGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCAT CATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCG CAGGAACAACAG SEQ ID NO:230

pMON35726.seq

GCCCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGC CCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGG CGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGC CCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTG GATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAACGCGTGAACACGGAGATA CACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTTTTTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTG CTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACC TGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCT CCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGG CAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:231

pMON35744.seq

GCTTCAAATCTGCAGGATGAAGAGCTGTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGG AGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT TGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCC TGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATC CGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC TTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAG AGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAA ACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGA GGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATC ATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGC AGGAACAACAG SEQ ID NO:232

pMON35745.seq

GCTAATCTGCAAGATGAGGAGCTGTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGC GGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT CACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTG CAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGG AGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGG AGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTC GCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCAC CGTGGCCTCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAAC CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAA TTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGA TATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAA AATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCT CTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGT TACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:233

pMON35746.seq

GCGCTGCAGGATGAAGAGCTGTGTGGCGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTTGATGGAGCGGC TCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCAC CAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAG GAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGC TGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGG TGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCT GTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAG AGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAA ACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGA GGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATC ATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGC AGGAACAACAG SEQ ID NO:234

pMON35747.seq

GCGCAAGATGAGGAACTGTGTGGTGGTCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAA ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGG CTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC AAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCCCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAG AGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAA ACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGA GGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATC ATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGC AGGAACAACAG SEQ ID NO:235

pMON35748.seq

GCTGAAGAACTGTGTGGTGGCCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTG TCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGC CTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGG ATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCC GACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCA ACCTGCAGGACTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAA CCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAA ATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGG ATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGA AAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCC TCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGG TTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:236

pMON35749.seq

GCTCTGTGCGGTGGCCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCA GCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAG CTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG ACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGG TAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAG CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAG AGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAA ACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGA GGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATC ATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGC AGGAACAACAG SEQ ID NO:237

pMON35750.seq

GCACTGTGTGGTGGTCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCA GCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAG CTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG ACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGG TAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAG CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAG AGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAA ACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGA GGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATC ATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGC AGGAACAACAG SEQ ID NO:238

pMON35769.seq

GCTCTGTGTGGCGGTCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCA GCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCG CCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCGGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTG GATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTC CGACTTCGCTGTCAAGATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC AACCTGCAGGACGAGGAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTA CTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGAT CGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAA GACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGC ACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGC CGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:239

pMON35771.seq

GCCTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTC AGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCA GCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC GACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACT GCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCT TCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTG GTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGCTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACC TAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGA ACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTC TTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGC AGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAA CAG SEQ ID NO:240

pMON35774.seq

GCTCAAGATGATGAGCTGTGTGGTGGTCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAA ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGCGGTGGTTCTGGCGGAGG ATCCGGCGGCGGAAGCGGAGGTGGCTCTGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGC CCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA CCGTGGCCTCCAACCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTAC TATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATC GATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAG ACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCA CTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCC GCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCT ATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:241

pMON35775.seq

GCCCAAGATGAAGAACTGTGTGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACG GAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACA TCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTT CTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGCCGCCACCGTGGAGCCCGCGTCCA CTCGGCGCCACCGCACCGACCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTG TCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGTACGT AGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCT AAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAA AGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACG AAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATT GAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCA TCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGC GCAGGAACAACAG SEQ ID NO:242

pMON35776.seq

GCCCAAGATGAAGAACTGTGTGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAA ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTCAACCCTGCCGCCACCGTGGAGCCCGCGTCCACTCGGCGCCACCGCACCGAC CGCTGGACAACCGCCTCTGACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC AAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACA TCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTG ATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCAT CAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACA TCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTT GAGCAAGCGCAGGAACAACAG SEQ ID NO:243

pMON32169.seq/pMON40000.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACC GTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCT GATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTG TCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGC CTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGG GGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC AACCTGCAG SEQ ID NO:244

pMON32188.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACC GTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCA AATCTGCAAGACGAGGAGCTGTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGC TCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCAC CAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGATCAACATCTCCCGCCTCCTGCAG GAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGC TGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGG TGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCT GTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC SEQ ID NO:245

pMON32273.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCT GCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGG GCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTC GCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCC AGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCT GCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGA GGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATA AATCTCCAAACATGGCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGA GACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTG CAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTG GCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGT CAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGAC GAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCG CTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTT TCAGCCC SEQ ID NO:246

pMON35795.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCT GCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGA GGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATA AATCTCCAAACATGGCTCTGCAGGATGAGGAACTGTGCGGCGGCCTCTGGCGGCTGGTCCTGGCACAGCG CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAG ATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTC CCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCT CCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGC CTCCAAC SEQ ID NO:247

pMON35796.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACC GTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCT CAAGATGAAGAGCTGTGTGGTGGTCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTC AGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG SEQ ID NO:248

pMON35797.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACC GTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCT GAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCG CTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTT TCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAG CAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGC CCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGG AGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGT GAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCT GCAGGAC SEQ ID NO:249

pMON35798.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACC GTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCT GAGCTGTGTGGTGGCCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCA GCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAG CTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG ACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGG TAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAG CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAG SEQ ID NO:250

pMON35799.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTG CCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCG CCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCA GGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTG CAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAG GCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAA ATCTCCAAACATGGCTCTGTGCGGTGGTCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCA AATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGA GACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTG CAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTG GCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGT CAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGAC GAGGAG SEQ ID NO:251

pMON39914.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATC TGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGG AGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCAT AAATCTCCAAACATGGCTGATGAAGAACTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGA TGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACA CTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGT GCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGCCGCCACCGTGGAGCCCGCGTCCACTCGGCGC CACCGCACCGACCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:252

pMON39915.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACC GTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCT GATGAAGAACTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTG TCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGC CTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGCGGTGGTTCTGGCGGAGGATCCGG CGGCGGAAGCGGAGGTGGCTCTGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATC TCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGG CCTCCAACCTGCAG SEQ ID NO:253

pMON39916.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACC GTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCT GATGAAGAACTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTG TCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGC CTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCCGACTCCTCAACCCTGCCGCCACCGTGGAGCCCGCGTCCACTCGGCGCCACCGCACCGACCGCTGG ACAACCGCCTCTGACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAA CCTGCAG SEQ ID NO:254

pMON35712.seq

GCCGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGG TCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCG CGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTC CAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC GCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGG AGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCC GACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAA SEQ ID NO:255

pMON35713.seq

GCCGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGA TGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACA CTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGT GCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGG ATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG SEQ ID NO:256

pMON35714.seq

GCCGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAAT GTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGAC CTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGG TGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGG AGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACT SEQ ID NO:257

pMON35715.seq

GCCTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTC AGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCA GCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC GACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACT GCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCT TCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTG GTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGG SEQ ID NO:258

pMON35716.seq

GCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGC TGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA CTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGC TCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC AAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGT CCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGC GTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC SEQ ID NO:259

pMON35717.seq

GCCCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGC CCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGG CGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGC CCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTG GATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATA CACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTT SEQ ID NO:260

pMON35718.seq

GCCACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC GCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGG AGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCC GACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCA ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCT CAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC AAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAG SEQ ID NO:261

pMON32170.seq

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCC GCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCG GTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGT GGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCT CCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTC CAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAAC CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCATTGGGCCCTGCCAGCTCCC TGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCA GGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGC ATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCC ATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCAC CTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGA ATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAG GAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGC GCAGCCC SEQ ID NO:262

pMON32187.seq

GCAGATGAAGAACTGTGTGGGGGACTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTC AGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTC CAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAAC CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCC TGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCA GGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGC ATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCC ATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCAC CTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGA ATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAG GAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGC GCAGCCC SEQ ID NO:263

pMON32271.seq

GCTGATGAAGAACTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGCCGCCACCGTGGAGCCCGCGTCCACTCGGCGCCACCGCACCGACCGC TGGACAACCGCCTCTGACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGTACGTAGAGG GCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGGCTACACCATTGGGCCCTGCCAG CTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCG CTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTC TGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCA ACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGT CCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAAC TGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCG GGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCAC CTTGCGCAGCCG SEQ ID NO:264

pMON32272.seq

GCTGATGAAGAACTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGCGGTGGTTCTGGCGGAGGATC CGGCGGCGGAAGCGGAGGTGGCTCTGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCC ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCG TGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAA CATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTG AGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCG AGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGC CCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCC CTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCA CCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCC GGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTG GAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCG SEQ ID NO:265

pMON32274.seq

GCTGATGAAGAACTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGCCGCCACCGTGGAGCCCGCGTCCACTCGGCGCCACCGCACCGACCAC CCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGAC TACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGTACGTAGAGGGCGGTGGAGGCTCCCCGG GTGGTGGTTCTGGCGGCGGCTCCAACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTT CCTGCTCAAGTCTTTAGAGCAAGTGAGRAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGT GCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTC CCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTT CCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTG CAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCC TGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGT TGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCG SEQ ID NO:266

pMON35751.seq

GCGGATGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAGGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGG TACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCT GACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCT CCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATC TCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAG CAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCC ACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAG CCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTG CAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACT TTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGC CATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGC TTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:267

pMON35752.seq

GCCGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCAC CCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGAC TACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGC TTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGC TGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTG CCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCG CCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCA GGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTG CAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:268

pMON35753.seq

GCAGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTC AGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTG CTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCA CCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCT GAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTC TACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGC TGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAA TGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGG AGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTGTACGCCACCTTGCG CAGCCC SEQ ID NO:269

pMON35754.seq

GCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGC TGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA CTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGC TCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC AAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGT CCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGC GTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCGTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTACACCATTAGGCCCTGCCAGCTCCGTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAA GTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACC CCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCA GGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTG CCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCAT GCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTC CTGGAGGTGTCGTACCGCGTTATACGCCACCTTGCGCAGCCC SEQ ID NO:270

pMON35755.seq

GCTTCAAATCTGCAGGATGAAGAGCTGTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGG AGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT TGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCC TGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATC CGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC TTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCATCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTG CTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCA CCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCT GAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTC TACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGC TGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCA GCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCT AGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:271

pMON35756.seq

GCTAATCTGCAAGATGAGGAGCTGTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGC GGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT CACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTG CAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGG AGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGG TCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCC CCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCAC CGTGGCCTCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAAC CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCC TGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCA GGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGC ATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCC ATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCAC CTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGA ATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAG GAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTATACGCCACCTTGC GCAGCCC SEQ ID NO:272

pMON35757.seq

GCGCTGCAGGATGAAGAGCTGTGTGGCGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTTGATGGAGCGGC TCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCAC CAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAG GAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGC TGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGG TGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCT GTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAG AGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGC TGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTG GGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGC CTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACA CACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCC TGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTC CTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:273

pMON35758.seq

GCACTGTGCGGTGGTCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCA GCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAG CTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTACAGTGTCAGCCCG ACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGG TAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAG CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTG CTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCA CCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCT GAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTC TACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGC TGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAA TGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGG AGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCG CAGCCC SEQ ID NO:274

pMON35759.seq

GCCTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTC AGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCA GCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC GACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACT GCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCT TCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTG GTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGCTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAA GTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACC CCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCA GGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTG CCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCAT GCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTC CTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:275

pMON35760.seq

GCCTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTC AGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCA GCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC GACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACT GCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCT TCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTG GTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGCTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAA GTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACC CCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCA GGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTG CCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCAT GCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTC CTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:276

pMON35761.seq

GCGCTGTGTGGTGGTCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCA GCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAG CTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCGGCCCG ACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCG GAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCAACTT CGCTGTCAAGATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG CAGGACGAGGAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATTTTTACTATCA ACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTC CCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTC CAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGG GCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACT CCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCC ACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGG GAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGC AGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTT GCGCAGCCC SEQ ID NO:277

pMON35762.seq

GCTGAACTGTGTGGTGGTCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCG CTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTT TCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAG CAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGC CCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGG AGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGT GAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCA GAGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAG CTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCT GGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGG CCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGAC ACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCC CTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGT CCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:278

pMON35763.seq

GCTGAAGAACTGTGTGGTGGCCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTG TCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGC CTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGG GGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTG CTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCA CCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCT GAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTC TACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGC TGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGA ATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAG GAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGC GCAGCCC SEQ ID NO:279

pMON35764.seq

GCTCAGGACGAGGAACTGTGTGGTGGTCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAA ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGG CTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC AAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTG CTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCA CCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCT GAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTC TACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGC TGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCA GCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCT AGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:280

pMON35765.seq

GCCACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC GCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGG AGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCC GACTTTGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCA ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCT CAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC AAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAA GTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACC CCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCA GGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTG CCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCAT GCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTC CTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:281

pMON35766.seq/pMON32190.seq/pMON40001.seq

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCT CCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGC CTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATG GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCG SEQ ID NO:282

pMON35768.seq

GCTCAAGATGAAGAACTGTGCGGTGGTCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAA ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGCGGATCCGGAGGTGG CTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTCCGCTGTC AAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAG AGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGC TGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTG GGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGC CTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACA CACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCC TGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTC CTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:283

pMON35770.seq

GCGCTGTGTGGTGGCCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATATGCCTTTCA GCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAG CTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCGGCCCG ACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCA GGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAGATCCGTGAGCTGTCTGACTAC CTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGTACGTAGAGGGCGGTGGAG GCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAA ATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTA GAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGT GCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCC CAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTC CTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCG ACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCT GCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCC TGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:284

pMON35772.seq

GCCTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTC AGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCA GCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTTCCGGTGCCTGGAGCTGCAGTGTCAGCCC GACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACT GCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCT TCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTG GTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGCTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAA GTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACC CCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCA GGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTG CCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCAT GCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTC CTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:285

pMON35773.seq

GCTCAAGACGAAGAACTGTGTGGTGGTCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAA ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGCGGTGGTTCTGGCGGAGG ATCCGGCGGCGGAAGCGGAGGTGGCTCTGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGC CCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA CCGTGGCCTCCAACCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTAC TATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCC AGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAG CGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTC TCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGC CAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGG GTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGA ACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGC CGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCC ACCTTGCGCAGCCC SEQ ID NO:286

pMON35777.seq

GCCCAAGATGAAGAACTGTGTGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAA ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTCAACCCTGCCGCCACCGTGGAGCCCGCGTCCA CTCGGCGCCACCGCACCGACCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTG TCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGTACGT AGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCT AAAGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCC TGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGC CACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCC CTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCC TCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCA GCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTG CAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTG CTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:287

pMON35778.seq

GCCCAAGATGAAGAACTGTGTGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAA ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTCAACCCTGCCGCCACCGTGGAGCCCGCGTCCACTCGGCGCCACCGCACCGAC CGCTGGACAACCGCCTCTGACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC AAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGC TTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGT GTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGC TCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTT TTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACAC TGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGC CCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTG GTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:288

pMON35779.seq

GCTGATGAAGAACTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGCGGTGGTTCTGGCGGAGGATC CGGCGGCGGAAGCGGAGGTGGCTCTGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCC ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCG TGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTAC TATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCC AGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAG CGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTC TCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGC CAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGG GTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCA TCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTT CGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTG TCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:289

pMON35780.seq

GCTGATGAAGAACTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCCCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGCGGTGGTTCTGGCGGAGGATC CGGCGGCGGAAGCGGAGGTGGCTCTGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCC ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCG TGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTAC TATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCC AGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAG CGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTC TCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGC CAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGG GTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGA ACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGC CGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCC ACCTTGCGCAGCCC SEQ ID NO:290

pMON35782.seq

GCGGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGCCGCCACCGTGGAGCCCGCGTCCACTCGGCGCCACCGCACCGACCGC TGGACAACCGCCTCTGACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAG AGGGCGGTGGAGGCACCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTG CTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCA CCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCT GAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTC TACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGC TGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCA GCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCT AGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:291

pMON39908.seq

GCTGATGAGGAGCTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGTAGAGACGGTGTTTCACCGTGTCAGCCAGGATGGTCTAGA TCTCCTGACCTCGACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAGAGG GCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGGCTACACCATTGGGCCCTGCCAG CTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCG CTCCAGGAGAAGCTGTGTGCCACTAACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTC TGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCA ACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGT CCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAAC TGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCG GGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCAC CTTGCGCAGCCG SEQ ID NO:292

pMON32275.seq

GCTGATGAAGAACTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAAT CTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCATTGGGC CCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATG GCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGG ACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGC TTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCC CCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGC AGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGC TTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGC GTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAA TCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCAACCCAGGACTG CTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTT CAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:293

pMON35781.seq

GCCACCCAGGACTGCTCCTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGAGCCGAAGAGCCCGGACAC CCATACTAGTCCGCCATCTCCGACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAG TCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACA AGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTC CTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAG GGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGCCCCACCTTGGACACACTGCAGCTGGACG TCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCAC CCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTCTGCAGAACCGAAAT CTCCGGATACTCATACCAGCCCGCCATCCCCGGGTTCTAATCTGCAAGATGAAGAGCTGTGCGGGGGCCT CTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGC TTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGCC TTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCA GCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC GACTCCTCAACCCTG SEQ ID NO:294

pMON35783.seq

GCCACCCAGGACTGCTCCTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGG CCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA GGCTGGCAGGGGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCCGAAGAGCCCGGACA CCCATACTAGTCCGCCATCTCCGGGTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCT CAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACT ACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAG CTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTAC CAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGG ACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCC CACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGC CATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTCTGCAGAACCGA AATCTCCGGATACTCATACCAGCCCGCCATCCCCGGGTAAGGCCTTTCAGCCCCCCCCCAGCTGTCTTCG CTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG SEQ ID NO:295

pMON32276.seq

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATC TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCC CGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGG TGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTCCTCCTTCCAACACAGCCCCATCTCC TCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCT CCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGGC TACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAG ATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACTAACAAGCTGTGCCACCCCGAGGAGC TGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCA GCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAA GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCA TCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTT CGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTG TCGTACCGCGTTCTACGCCACCTTGCGCAGCCG SEQ ID NO:296

pMON32277.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCA TCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGT GGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTC ATAAATCTCCAAACATGGCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTG GATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATA CACTTTGTCACCAAATCTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCC GCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCG GTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGT GGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTCCTCCTTCCAACACAGCCCCATCTCCT CCGACTTCGCTGTCAAAATCCGCGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTC CAACCTGCAG SEQ ID NO:297

pMON32278.seq

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTCTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTAGAGCTGCAGT CTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTC AGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGGCTACACCATTGGGCCCTGC CAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCA GCGCTCCAGGAGAAGCTGTGTGCCACTAACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACT CTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAG CCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTG GGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAG AACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCG CCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGC CACCTTGCGCAGCCG SEQ ID NO:298

pMON32279.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACC GTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCA GATGAAGAACTGTGTGGGGGCCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTG TCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGC CTTTCAGCCCCCCCCCAGCTCTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTCTC AGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGG GGGAGGTAGTGGTACTCAGGACTGTTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTC CAACCTGCAG SEQ ID NO:299

pMON35790.seq

GCCACTCAGGACTCCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGG CCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATCTGCCTTTCAGCCCCCCCCCAGCT GTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG TACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGGCTACACCATTGG GCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGA TGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACTAACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTC GGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCT GCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCC CGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAG ATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTT TCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGT TCTACGCCACCTTGCGCAGCCG SEQ ID NO:300

pMON35791.seq

GCCACTCAGGACTGTTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGG CCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCC TTTCAGCCCCCCCCCAGCTCTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCG AGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTCTCA GCCCGACTCCTCAACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCC AACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAG TGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCC CGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAG GCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGG CCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGC CACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATG CCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCC TGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCG SEQ ID NO:301

pMON35792.seq

GCCACTCAGGACTGTTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGG CCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCT GTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTACGTAGAGGGCGGTGGAGGCTCC CCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGA GCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCT GTGTGCCACTAACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGG CATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTC CATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCA CCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGG AATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCA GGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTG CGCAGCCG SEQ ID NO:302

pMON39905.seq

GCCACTCAGGACTGTTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGG CCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCT GTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTCTCAGCCCGACTCCTCAACCCTG TACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGGCTACACCATTGG GCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGA TGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTC GGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCT GCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCC CGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAG ATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTT TCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGT TCTACGCCACCTTGCGCAGCCG SEQ ID NO:303

pMON39906.seq

GCCACTCAGGACTGTTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGG CCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCT GTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA GCCCTGGATCACTCGCCAGAACTTCTCCCGGCGCCTGGAGCTGCAGTCTCAGCCCGACTCCTCAACCCTG TACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGGCTACACCATTGG GCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGA TGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACTAACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTC GGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCT GCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCC CGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAG ATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTT TCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGT TCTACGCCACCTTGCGCAGCCG SEQ ID NO:304

pMON39909.seq

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAG GTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTC CTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCC TCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGG CTACTCAAGGTGCTATGCCAGCTTTTGCTTCTGCTTTTCAACGTCGTGCAGGTGGTGTTCTGGTTGCTAG CCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTCTGGCGGCTCT GGCGGCTCTCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGC TCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCT GGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAA CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTC CCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACT GGGAATGGCCCCTGCCCTGCAGCCC SEQ ID NO:305

pMON39910.seq

GCTACTCAAGGTGCTATGCCAGCTTTTGCTTCTGCTTTTCAACGTCGTGCAGGTGGTGTTCTGGTTGCTA GCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTCTGGCGGCTC TGGCGGCTCTCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCG CTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTC TGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCA ACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGT CCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAAC TGGGAATGGCCCCTGCCCTGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC AATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTC GCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCT TTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGA GCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAG CCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGG GAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCG TGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:306

pMON35727.seq

GCCGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGAAC CCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGAC TACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGG CTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCA GGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAG CTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAG GTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCT GTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:307

pMON32168.seq

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTC AGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA AGAATCTCATAAATCTCCAAACATGGCTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC TTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAAATTACCCAGTCACCGTGGCCTCCAACC TGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAA GACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAA TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGA CCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA GTGTCAGCCCGACTCCTCAACCCTG SEQ ID NO:308

pMON32195.seq

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCC CGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAG GTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTC CTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCC TCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGG CTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAA GATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAG CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGC AGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGA AGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACC ATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCT TCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGT GTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCG TCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTG ATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGT CGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCC TTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCG AGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCA GCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGG GGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCC GTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:309

pMON32196.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACC GTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCT GATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTG TCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGC CTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGG GGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAGAGG GCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGA ATCTCATAAATCTCCAAACATGGCTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTC GCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGC AGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGAC TGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGT GCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCT CCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTG TCAGCCCGACTCCTCAACCCTG SEQ ID NO:310

pMON32197.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAA AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGA GCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG AAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCAC CATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCC TTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACC GTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCT GATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTG TCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGC CTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGG GGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAGAGG GCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGA ATCTCATAAATCTCCAAACATGGCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAG CGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGG AGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTT CGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATC ACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGT CAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTT CCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGAT TACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:311

pMON32206.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACC CGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAG CTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCA TGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAAT TCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT CATAAATCTCCAAACATGGCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCT GGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGAT ACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCC CGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGG TGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCC TCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCT CCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAA CCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTGATGAA GAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCA GCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAG CTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG ACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGG TAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAG CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:312

pMON32207.seq

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTC AGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAG AGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGGCTGATGAAGAACTGTGTGG TGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATG CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCA GCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCT GAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC CTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCC AGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAA AATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTA GAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTA AAGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCT GCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCC ACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCC TGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCT CTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAG CTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGC AGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGC TAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTGATAAGGA TCCGAATTCGGCAGC SEQ ID NO:313

pMON35728.seq

GCCGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGAAC CCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGAC TACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCC CGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCC AAACATGGCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTG CTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACT CCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTC GTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGG TGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG TACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTC CGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGT CCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGC GTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCC AGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCG CCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGA GGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCG ACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAA CCTGCAG SEQ ID NO:314

pMON32183.seq

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGA CTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGT GTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTC AGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGAATTCA AGCTTGAGCCCAGAGGGCCCACAATCAAGCCCTGTCCTCCATGCAAATGCCCAGCACCTAACCTCTTGGG TGGACCATCCGTCTTCATCTTCCCTCCAAAGATCAAGGATGTACTCATGATCTCCCTGAG CCCCATAGTCACATGTGTGGTGGTGGATGTGAGCGAGGATGACCCAGATGTCCAGATCAGCTGGTTTGTG AACAACGTGGAAGTACACACAGCTCAGACACAAACCCATAGAGAGGATTACAACAGTACTCTCCGGGCGG TCAGTGCCCTCCCCATCCAGCACCAGGACTGGATGAGTGGCAAGGAGTTCAAATGCAAGGTCAACAACAA AGACCTCCCAGCGCCCATCGAGAGAACCATCTCAAAACCCAAAGGGTCAGTAAGAGCTCCACAGGTATAT GTCTTGCCTCCACCAGAAGAAGAGATGACTAAGAAACAGGTCACTCTGACCTGCATGGTCACAGACTTCA TGCCTGAAGACATTTACGTGGAGTGGACCAACAACGGGAAAACAGAGCTAAACTACAAGAACACTGAACC AGTCCTGGACTCTGATGGTTCTTACTTCATGTACAGCAAGCTGAGAGTGGAAAAGAAGAACTGGGTGGAA AGAAATAGCTACTCCTGTTCAGTGGTCCACGAGGGTCTGCACAATCACCACACGACTAAGAGCTTCTCCC GGACTCCGGGTAAA SEQ ID NO:315

pMON32184.seq

GCCACCCAGGACTGCTCCTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGG CCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCT GTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG GAATTCAAGCTTGAGCCCAGAGGGCCCACAATCAAGCCCTGTCCTCCATGCAAATGCCCAGCACCTAACC TCTTGGGTGGACCATCCGTCTTCATCTTCCCTCCAAAGATCAAGGATGTACTCATGATCTCCCTGAGCCC CATAGTCACATGTGTGGTGGTGGATGTGAGCGAGGATGACCCAGATGTCCAGATCAGCTGGTTTGTGAAC AACGTGGAAGTACACACAGCTCAGACACAAACCCATAGAGAGGATTACAACAGTACTCTCCGGGCGGTCA GTGCCCTCCCCATCCAGCACCAGGACTGGATGAGTGGCAAGGAGTTCAAATGCAAGGTCAACAACAAAGA CCTCCCAGCGCCCATCGAGAGAACCATCTCAAAACCCAAAGGGTCAGTAAGAGCTCCACAGGTATATGTC TTGCCTCCACCAGAAGAAGAGATGACTAAGAAACAGGTCACTCTGACCTG CATGGTCACAGACTTCATGCCTGAAGACATTTACGTGGAGTGGACCAACAACGGGAAAACAGAGCTAAAC TACAAGAACACTGAACCAGTCCTGGACTCTGATGGTTCTTACTTCATGTACAGCAAGCTGAGAGTGGAAA AGAAGAACTGGGTGGAAAGAAATAGCTACTCCTGTTCAGTGGTCCACGAGGGTCTGCACAATCACCACAC GACTAAGAGCTTCTCCCGGACTCCGGGTAAA SEQ ID NO:316

[표 3]

단백질 서열

pMON26458pep

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis

ValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeu

LeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAla

GlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGln

LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeu

LeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAla

HisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArg

PheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPhe SEQ ID NO:467

pMON28548pep

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis

ValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeu

LeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAla

GlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGln

LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeu

LeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAla

HisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArg

PheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnMetAla

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis

ValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeu

LeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAla

GlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGln

LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeu

LeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnGlyArgThrThrAlaHisLysAspPro

AsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeu

ValGlyGlySerThrLeuCysValArg SEQ ID NO:468

pMON28500

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeuHis SerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeuLeuProAlaValAspPhe SerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThrLeu LeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGln LeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGln GlyArgThrThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLys ValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGlyAsnMetAlaSerPro AlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeu HisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeuLeuProAlaValAsp PheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThr LeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGly GlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProPro GlnGlyArgThrThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGly LysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArg SEQ ID NO:469

pMON28501

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis

ValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeu

LeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAla

GlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGln

LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeu

LeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAla

HisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArg

PheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnMetAla

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis

ValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeu

LeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAla

GlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGln

LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeu

LeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAla

HisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArg

PheLeuMetLeuValGlyGlySerThrLeuCysValArg SEQ ID NO:470

pMON28502

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis

ValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeu

LeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAla

GlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGln

LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeu

LeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAla

HisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArg

PheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnGlyGly

AsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArg

AspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThr

ProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGlu

ThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAla

ArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnVal

ArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArg

ThrThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGly

LysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArg SEQ ID NO:471

13182.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Tyr Lys Leu Cys

His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro

Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala

Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly

Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr

Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile

Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly

Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val

Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys

Ala Thr SEQ ID NO:472

13183.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Tyr Lys Leu Cys

His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro

Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala

Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly

Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr

Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile

Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly

Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val

Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys

Ala Thr SEQ ID NO:473

13184.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr

Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser

Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu

Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu

Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys

Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His

Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly

Ile Ser SEQ ID NO:474

13185.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr

Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser

Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu

Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu

Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys

Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His

Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly

Ile Ser SEQ ID NO:475

13186.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Met Ala Pro Ala

Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe

Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro

Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu

Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu

Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val

Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser

Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu

His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu

Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu

Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu

Leu Gly SEQ ID NO:476

13187.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Met Ala Pro Ala

Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe

Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro

Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu

Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu

Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val

Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser

Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu

His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu

Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu

Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu

Leu Gly SEQ ID NO:477

13188.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Thr Gln Gly Ala

Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val

Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg

Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser

Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln

Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys

Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly

Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln

Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr

Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr

Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gln Pro SEQ ID NO:478

13189.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Gln Gly Ala

Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val

Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg

Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser

Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln

Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys

Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly

Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln

Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr

Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr

Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gln Pro SEQ ID NO:479

13190.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser

Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu

Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu

Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys

Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His

Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly

Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp

Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu

Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala

Phe Ala SEQ ID NO:480

13191.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser

Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu

Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu

Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys

Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His

Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly

Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp

Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu

Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala

Phe Ala SEQ ID NO:481

13192.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Tyr Lys Leu Cys

His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro

Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala

Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly

Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr

Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile

Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr Pro Leu

Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu

Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu

Lys Leu Cys Ala Thr SEQ ID NO:482

13193.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Tyr Lys Leu Cys

His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro

Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala

Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly

Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr

Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile

Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr Pro Leu

Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu

Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu

Lys Leu Cys Ala Thr SEQ ID NO:483

25190.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr

Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr

Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys

Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu

Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu

Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu

Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser

Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala

Leu Glu Gly Ile Ser SEQ ID NO:484

pMON25191.Pep

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr

Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr

Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys

Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu

Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu

Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu

Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser

Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala

Leu Glu Gly Ile Ser SEQ ID NO:485

13194.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Met Ala Pro Ala

Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe

Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu

Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala

Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu

Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro

Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu

Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln

Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr

Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln

Met Glu Glu Leu Gly SEQ ID NO:486

13195.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Met Ala Pro Ala

Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe

Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu

Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala

Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu

Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro

Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu

Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln

Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr

Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln

Met Glu Glu Leu Gly SEQ ID NO:487

13196.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Thr Gln Gly Ala

Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val

Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg

Val Leu Arg His Leu Ala Gln Pro Thr Pro Leu Gly Pro Ala Ser

Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg

Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala

Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His

Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln

Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu

Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro

Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp

Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala

Pro Ala Leu Gln Pro SEQ ID NO:488

13197.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Gln Gly Ala

Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val

Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg

Val Leu Arg His Leu Ala Gln Pro Thr Pro Leu Gly Pro Ala Ser

Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg

Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala

Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His

Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln

Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu

Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro

Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp

Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala

Pro Ala Leu Gln Pro SEQ ID NO:489

13198.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr

Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys

Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu

Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu

Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu

Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser

Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala

Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu

Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met

Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala

Met Pro Ala Phe Ala SEQ ID NO:490

13199.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr

Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys

Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu

Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu

Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu

Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser

Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala

Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu

Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met

Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala

Met Pro Ala Phe Ala SEQ ID NO:491

31104.Pep

Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met

Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala

Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg

Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg

His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln

Gln Gly Gly Gly Ser Asn Cys Ser Ile Met Ile Asp Glu Ile Ile

His His Leu Lys Arg Pro Pro Ala Pro Leu Tyr Val Glu Gly Gly

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly

Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val

Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser

Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly

Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala

Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met

Ala Pro Ala Leu Gln Pro SEQ ID NO:492

31105.Pep

Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys

Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile

Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr

Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Tyr Val Glu Gly Gly

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly

Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val

Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser

Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly

Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala

Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met

Ala Pro Ala Leu Gln Pro SEQ ID NO:493

31106.Pep

Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln

Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln

Ala Gln Glu Gln Gln Gly Gly Gly Ser Asn Cys Ser Ile Met Ile

Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu

Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met Asp

Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val

Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn

Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Tyr Val Glu Gly Gly

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly

Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val

Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser

Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly

Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala

Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met

Ala Pro Ala Leu Gln Pro SEQ ID NO:494

31107.Pep

Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu

Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser Asn

Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro

Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val

Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser

Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu

Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala

Ala Pro Ser Arg His Pro Ile Ile Ile Lys Tyr Val Glu Gly Gly

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly

Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val

Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser

Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly

Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala

Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met

Ala Pro Ala Leu Gln Pro SEQ ID NO:495

31108.Pep

Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met

Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala

Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg

Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg

His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln

Gln Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn Cys

Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro

Ala Pro Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro

Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu

Ser His Lys Ser Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala

Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe

Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly

Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp

Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly

Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu

Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu

Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp

Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro SEQ ID NO:496

31109.Pep

Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys

Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile

Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr

Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser

Gly Gly Gly Ser Gly Gly Gly Ser Asn Cys Ser Ile Met Ile Asp

Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp

Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met Asp Arg

Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys

Asn Leu Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro

Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu

Ser His Lys Ser Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala

Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe

Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly

Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp

Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly

Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu

Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu

Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp

Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro

SEQ ID NO:497

31110.Pep

Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln

Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln

Ala Gln Glu Gln Gln Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly

Gly Ser Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu

Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp

Glu Asp Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn

Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser

Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser

Ala Thr Ala Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro

Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu

Ser His Lys Ser Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala

Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe

Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly

Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp

Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly

Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu

Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu

Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp

Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro

SEQ ID NO:498

31111.Pep

Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu

Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser Gly

Gly Gly Ser Gly Gly Gly Ser Asn Cys Ser Ile Met Ile Asp Glu

Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro

Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met Asp Arg Asn

Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn

Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln

Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile

Ile Ile Lys Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro

Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu

Ser His Lys Ser Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala

Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe

Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly

Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp

Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly

Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu

Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu

Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp

Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro

SEQ ID NO:499

pMON15981

MetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAla

ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsn

LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer

GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPro

SerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr

PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaTyrLysLeuCysHisProGluGluLeuValLeuLeu

GlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGln

LeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGln

AlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspVal

AlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeu

GlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGly

ValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHis

LeuAlaGlnProGlyGlyGlySerAspMetAlaThrProLeuGlyProAlaSerSerLeu

ProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAla

AlaLeuGlnGluLysLeuCysAlaThr SEQ ID NO:500

pMON15982

MetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAla

ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsn

LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer

GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPro

SerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr

PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaProGluLeuGlyProThrLeuAspThrLeuGlnLeu

AspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaPro

AlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAla

GlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeu

ArgHisLeuAlaGlnProGlyGlyGlySerAspMetAlaThrProLeuGlyProAlaSer

SerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAsp

GlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeu

ValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGln

AlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGly

LeuLeuGlnAlaLeuGluGlyIleSer SEQ ID NO:501

pMON15965

MetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAla

ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsn

LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer

GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPro

SerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr

PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuVal

AlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGln

ProGlyGlyGlySerAspMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSer

PheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGln

GluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHis

SerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAla

GlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeu

GluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAsp

PheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnPro

ThrGlnGlyAlaMetProAlaPheAla SEQ ID NO:502

pMON15966

MetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAla

ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsn

LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer

GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPro

SerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr

PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaMetAlaProAlaLeuGlnProThrGlnGlyAlaMet

ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeu

GlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProGlyGlyGly

SerAspMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLys

SerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCys

AlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIle

ProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSer

GlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSer

ProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThr

IleTrpGlnGlnMetGluGluLeuGly SEQ ID NO:503

pMON15967

MetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAla

ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsn

LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer

GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPro

SerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr

PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaThrGlnGlyAlaMetProAlaPheAlaSerAlaPhe

GlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSer

TyrArgValLeuArgHisLeuAlaGlnProGlyGlyGlySerAspMetAlaThrProLeu

GlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLys

IleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHis

ProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSer

CysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPhe

LeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeu

AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGlu

LeuGlyMetAlaProAlaLeuGlnPro SEQ ID NO:504

pMON31112.pep

MetAlaAsnCysSerAsnMetIleAspGluIleIleThrHisLeuLysGlnProProLeu

ProLeuLeuAspPheAsnAsnLeuAsnGlyGluAspGlnAspIleLeuMetAspAsnAsn

LeuArgArgProAsnLeuGluAlaPheAsnArgAlaValLysSerLeuGlnAsnAlaSer

AlaIleGluSerIleLeuLysAsnLeuLeuProCysLeuProLeuAlaThrAlaAlaPro

ThrArgHisProIleHisIleLysAspGlyAspTrpAsnGluPheArgArgLysLeuThr

PheTyrLeuLysThrLeuGluAsnAlaGlnAlaGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaThrGlnGlyAlaMetProAlaPheAlaSerAlaPhe

GlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSer

TyrArgValLeuArgHisLeuAlaGlnProSerGlyGlySerGlyGlySerGlnSerPhe

LeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGlu

LysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSer

LeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGly

CysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGlu

GlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPhe

AlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnPro

SEQ ID NO:505

pMON31113.pep

MetAlaAsnCysSerAsnMetIleAspGluIleIleThrHisLeuLysGlnProProLeu

ProLeuLeuAspPheAsnAsnLeuAsnGlyGluAspGlnAspIleLeuMetGluAsnAsn

LeuArgArgProAsnLeuGluAlaPheAsnArgAlaValLysSerLeuGlnAsnAlaSer

AlaIleGluSerIleLeuLysAsnLeuLeuProCysLeuProLeuAlaThrAlaAlaPro

ThrArgHisProIleIleIleArgAspGlyAspTrpAsnGluPheArgArgLysLeuThr

PheTyrLeuLysThrLeuGluAsnAlaGlnAlaGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaThrGlnGlyAlaMetProAlaPheAlaSerAlaPhe

GlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSer

TyrArgValLeuArgHisLeuAlaGlnProThrProLeuGlyProAlaSerSerLeuPro

GlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAla

LeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeu

GlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGln

LeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGln

AlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspVal

AlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeu

GlnPro SEQ ID NO:506

pMON31114.pep

MetAlaAsnCysSerAsnMetIleAspGluIleIleThrHisLeuLysGlnProProLeu

ProLeuLeuAspPheAsnAsnLeuAsnGlyGluAspGlnAspIleLeuMetGluAsnAsn

LeuArgArgProAsnLeuGluAlaPheAsnArgAlaValLysSerLeuGlnAsnAlaSer

AlaIleGluSerIleLeuLysAsnLeuLeuProCysLeuProLeuAlaThrAlaAlaPro

ThrArgHisProIleIleIleArgAspGlyAspTrpAsnGluPheArgArgLysLeuThr

PheTyrLeuLysThrLeuGluAsnAlaGlnAlaGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaThrGlnGlyAlaMetProAlaPheAlaSerAlaPhe

GlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSer

TyrArgValLeuArgHisLeuAlaGlnProSerGlyGlySerGlyGlySerGlnSerPhe

LeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGlu

LysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSer

LeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGly

CysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGlu

GlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPhe

AlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnPro

SEQ ID NO:507

pMON31115.pep

MetAlaAsnCysSerAsnMetIleAspGluIleIleThrHisLeuLysGlnProProLeu

ProLeuLeuAspPheAsnAsnLeuAsnGlyGluAspGlnAspIleLeuMetAspAsnAsn

LeuArgArgProAsnLeuGluAlaPheAsnArgAlaValLysSerLeuGlnAsnAlaSer

AlaIleGluSerIleLeuLysAsnLeuLeuProCysLeuProLeuAlaThrAlaAlaPro

ThrArgHisProIleHisIleLysAspGlyAspTrpAsnGluPheArgArgLysLeuThr

PheTyrLeuLysThrLeuGluAsnAlaGlnAlaGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaThrGlnGlyAlaMetProAlaPheAlaSerAlaPhe

GlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSer

TyrArgValLeuArgHisLeuAlaGlnProThrProLeuGlyProAlaSerSerLeuPro

GlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAla

LeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeu

GlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGln

LeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGln

AlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspVal

AlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeu

GlnPro SEQ ID NO:508

pMON28505

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGluValHisProLeuProThrProValLeuLeuProAlaVal

AspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAspIleLeu

GlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThr

CysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeu

GlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLysAspPro

AsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeu

ValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnMetAlaSerProAlaPro

ProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeuHisSer

ArgLeuSerGlnCysPro SEQ ID NO:509

pMON28506

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetLeuProThrProValLeuLeuProAlaValAspPheSerLeu

GlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThr

LeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSer

LeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeu

GlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLysAspProAsnAlaIlePhe

LeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySer

ThrLeuCysValArgGluPheGlyGlyAsnMetAlaSerProAlaProProAlaCysAsp

LeuArgValLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGln

CysProGluValHisPro SEQ ID NO:510

pMON28507

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLys

ThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGlu

GlyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGln

LeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeu

ProProGlnGlyArgThrThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGln

HisLeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysVal

ArgGluPheGlyGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeu

SerLysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluVal

HisProLeuProThrPro SEQ ID NO:511

pMON28508

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGlu

GluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAla

AlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGln

ValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGly

ArgThrThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArg

GlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGly

GlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeu

ArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuPro

ThrProValLeuLeuPro SEQ ID NO:512

pMON28509

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThr

LysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArg

GlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArg

LeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThr

ThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLys

ValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsn

MetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAsp

SerHisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrPro

ValLeuLeuProAlaVal SEQ ID NO:513

pMON28510

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAsp

IleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGly

ProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGly

AlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLys

AspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeu

MetLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnMetAlaSerPro

AlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeu

HisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeuLeuPro

AlaValAspPheSerLeu SEQ ID NO:514

pMON28511

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGly

GlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGln

GlyArgThrThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeu

ArgGlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPhe

GlyGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeu

LeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeu

ProThrProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMet

GluGluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMet

AlaAlaArgGlyGlnLeu SEQ ID NO:515

pMON28512

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLys

AspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeu

MetLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnMetAlaSerPro

AlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeu

HisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeuLeuPro

AlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAsp

IleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGly

ProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGly

AlaLeuGlnSerLeuLeu SEQ ID NO:516

pMON28513

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGlyArgThrThrAlaHisLysAspProAsnAlaIlePheLeu

SerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySerThr

LeuCysValArgGluPheGlyGlyAsnMetAlaSerProAlaProProAlaCysAspLeu

ArgValLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCys

ProGluValHisProLeuProThrProValLeuLeuProAlaValAspPheSerLeuGly

GluTrpLysThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThrLeu

LeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeu

LeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGly

ThrGlnLeuProProGln SEQ ID NO:517

pMON28514

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHis

LeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArg

GluPheGlyGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSer

LysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHis

ProLeuProThrProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThr

GlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGly

ValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeu

SerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuPro

ProGlnGlyArgThrThr SEQ ID NO:518

pMON28515

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArg

GlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGly

GlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeu

ArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuPro

ThrProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGlu

GluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAla

AlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGln

ValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGly

ArgThrThrAlaHisLys SEQ ID NO:519

pMON28516

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysVal

ArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnMet

AlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSer

HisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProVal

LeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLys

AlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGly

GlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeu

LeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThr

AlaHisLysAspProAsn SEQ ID NO:520

pMON28519

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGluValHisProLeuProThrProValLeuLeuProAlaVal

AspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAspIleLeu

GlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThr

CysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeu

GlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLysAspPro

AsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeu

ValGlyGlySerThrLeuCysValArgGluPheGlyAsnMetAlaSerProAlaProPro

AlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArg

LeuSerGlnCysPro SEQ ID NO:521

pMON28520

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetLeuProThrProValLeuLeuProAlaValAspPheSerLeu

GlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThr

LeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSer

LeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeu

GlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLysAspProAsnAlaIlePhe

LeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySer

ThrLeuCysValArgGluPheGlyAsnMetAlaSerProAlaProProAlaCysAspLeu

ArgValLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCys

ProGluValHisPro SEQ ID NO:522

pMON28521

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLys

ThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGlu

GlyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGln

LeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeu

ProProGlnGlyArgThrThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGln

HisLeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysVal

ArgGluPheGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSer

LysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHis

ProLeuProThrPro SEQ ID NO:523

pMON28522

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGlu

GluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAla

AlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGln

ValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGly

ArgThrThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArg

GlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGly

AsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArg

AspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThr

ProValLeuLeuPro SEQ ID NO:524

pMON28523

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThr

LysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArg

GlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArg

LeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThr

ThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLys

ValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGlyAsnMet

AlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSer

HisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProVal

LeuLeuProAlaVal SEQ ID NO:525

pMON28524

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAsp

IleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGly

ProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGly

AlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLys

AspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeu

MetLeuValGlyGlySerThrLeuCysValArgGluPheGlyAsnMetAlaSerProAla

ProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeuHis

SerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeuLeuProAla

ValAspPheSerLeu SEQ ID NO:526

pMON28525

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGly

GlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGln

GlyArgThrThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeu

ArgGlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPhe

GlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeu

ArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuPro

ThrProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGlu

GluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAla

AlaArgGlyGlnLeu SEQ ID NO:527

pMON28526

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLys

AspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeu

MetLeuValGlyGlySerThrLeuCysValArgGluPheGlyAsnMetAlaSerProAla

ProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeuHis

SerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeuLeuProAla

ValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAspIle

LeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyPro

ThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAla

LeuGlnSerLeuLeu SEQ ID NO:528

pMON28527

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGlyArgThrThrAlaHisLysAspProAsnAlaIlePheLeu

SerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySerThr

LeuCysValArgGluPheGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArg

ValLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysPro

GluValHisProLeuProThrProValLeuLeuProAlaValAspPheSerLeuGlyGlu

TrpLysThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeu

LeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeu

GlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThr

GlnLeuProProGln SEQ ID NO:529

pMON28528

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHis

LeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArg

GluPheGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLys

LeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHisPro

LeuProThrProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThrGln

MetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyVal

MetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSer

GlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProPro

GlnGlyArgThrThr SEQ ID NO:530

pMON28529

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArg

GlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGly

AsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArg

AspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThr

ProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGlu

ThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAla

ArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnVal

ArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArg

ThrThrAlaHisLys SEQ ID NO:531

pMON28530

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysVal

ArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGlyAsnMetAla

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis

ValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeu

LeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAla

GlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGln

LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeu

LeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAla

HisLysAspProAsn SEQ ID NO:532

pMON28533

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGluValHisProLeuProThrProValLeuLeuProAlaVal

AspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAspIleLeu

GlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThr

CysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeu

GlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLysAspPro

AsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeu

ValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnGlyGlyAsnMetAlaSer

ProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisVal

LeuHisSerArgLeuSerGlnCysPro SEQ ID NO:533

pMON28534

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetLeuProThrProValLeuLeuProAlaValAspPheSerLeu

GlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThr

LeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSer

LeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeu

GlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLysAspProAsnAlaIlePhe

LeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySer

ThrLeuCysValArgGluPheGlyGlyAsnGlyGlyAsnMetAlaSerProAlaProPro

AlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArg

LeuSerGlnCysProGluValHisPro SEQ ID NO:534

pMON28535

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLys

ThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGlu

GlyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGln

LeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeu

ProProGlnGlyArgThrThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGln

HisLeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysVal

ArgGluPheGlyGlyAsnGlyGlyAsnMetAlaSerProAlaProProAlaCysAspLeu

ArgValLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCys

ProGluValHisProLeuProThrPro SEQ ID NO:535

pMON28536

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGlu

GluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAla

AlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGln

ValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGly

ArgThrThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArg

GlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGly

GlyAsnGlyGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSer

LysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHis

ProLeuProThrProValLeuLeuPro SEQ ID NO:536

pMON28537

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThr

LysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArg

GlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArg

LeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThr

ThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLys

ValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsn

GlyGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeu

LeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeu

ProThrProValLeuLeuProAlaVal SEQ ID NO:537

pMON28538

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAsp

IleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGly

ProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGly

AlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLys

AspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeu

MetLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnGlyGlyAsnMet

AlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSer

HisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProVal

LeuLeuProAlaValAspPheSerLeu SEQ ID NO:538

pMON28539

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGly

GlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGln

GlyArgThrThrAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeu

ArgGlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPhe

GlyGlyAsnGlyGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeu

SerLysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluVal

HisProLeuProThrProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLys

ThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGlu

GlyValMetAlaAlaArgGlyGlnLeu SEQ ID NO:539

pMON28540

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLys

AspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeu

MetLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnGlyGlyAsnMet

AlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSer

HisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProVal

LeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLys

AlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGly

GlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeu

LeuLeuGlyAlaLeuGlnSerLeuLeu SEQ ID NO:540

pMON28541

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetGlyArgThrThrAlaHisLysAspProAsnAlaIlePheLeu

SerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySerThr

LeuCysValArgGluPheGlyGlyAsnGlyGlyAsnMetAlaSerProAlaProProAla

CysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArgLeu

SerGlnCysProGluValHisProLeuProThrProValLeuLeuProAlaValAspPhe

SerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAla

ValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeu

SerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSer

LeuLeuGlyThrGlnLeuProProGln SEQ ID NO:541

pMON28542

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaHisLysAspProAsnAlaIlePheLeuSerPheGlnHis

LeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArg

GluPheGlyGlyAsnGlyGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArg

ValLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysPro

GluValHisProLeuProThrProValLeuLeuProAlaValAspPheSerLeuGlyGlu

TrpLysThrGlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeu

LeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeu

GlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThr

GlnLeuProProGlnGlyArgThrThr SEQ ID NO:542

pMON28543

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArg

GlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGly

GlyAsnGlyGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSer

LysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHis

ProLeuProThrProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThr

GlnMetGluGluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGly

ValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeu

SerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuPro

ProGlnGlyArgThrThrAlaHisLys SEQ ID NO:543

pMON28544

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysVal

ArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnGly

GlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeu

ArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuPro

ThrProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGlu

GluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAla

AlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGln

ValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGly

ArgThrThrAlaHisLysAspProAsn SEQ ID NO:544

pMON28545

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArg

GlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGly

GlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeu

ArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuPro

ThrProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGlu

GluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAla

AlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGln

ValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnGlyArgThrThrAla

HisLys SEQ ID NO:545

pMON32132

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis

ValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeu

LeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAla

GlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGln

LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeu

LeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAla

HisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArg

PheLeuMetLeuValGlyGlySerThrLeuCysValArg SEQ ID NO:546

PMON32133

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis

ValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeu

LeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAla

GlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGln

LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeu

LeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnGlyArgThrThrAlaHisLysAspPro

AsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeu

ValGlyGlySerThrLeuCysValArg SEQ ID NO:547

PMON32134

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis

ValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProValLeu

LeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAla

GlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGln

LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeu

LeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAla

HisLysAspProAsnAlaIlePheLeuSerPheGlnHisLeuLeuArgGlyLysValArg

PheLeuMetLeuValGlyGlySerThrLeuCysValArg SEQ ID NO:548

pMON30237.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly AlaLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCys GlnPro SEQ ID NO:549

pMON30238.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer ThrLeu SEQ ID NO:550

pMON30239.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnGluThrSer GluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCys GlnProAspSerSerThrLeu SEQ ID NO:551

pMON32329.pep

GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGln CysGlnPro SEQ ID NO:552

pMON32330.pep

GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer ThrLeu SEQ ID NO:553

pMON32341.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro SEQ ID NO:554

pMON32342.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeu SEQ ID NO:555

pMON32320.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsn GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:556

pMON32321.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsnGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:557

pMON32322.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSer ProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal ThrValAlaSerAsnLeuGln SEQ ID NO:558

pMON32323.pep

AlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGln ProAspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGlyThrGln AspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyr LeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SEQ ID NO:559

pMON32324.pep

AlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGln ProAspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsnGlyThrGlnAspCysSerPheGln HisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyr ProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeu TrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SEQ ID NO:560

pMON32325.pep

AlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGln ProAspSerSerThrLeuSerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu ArgLeuLysThrValAlaGly SEQ ID NO:561

pMON32326.pep

AlaProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGlyThrGlnAsp CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeu LeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro SEQ ID NO:562

pMON32327.pep

AlaProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsnGlyThrGlnAsp CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeu LeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro SEQ ID NO:563

pMON32328.pep

AlaProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuSerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSer AspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSer AsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArg LeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal ThrLysCysAlaPheGlnPro SEQ ID NO:564

pMON32348.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuSerGlyGlySerGlySerGlyGlySerGlySerGlyGlySer GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:565

pMON32350.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuSerGlyGlySerGlySerGlyGlySerGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:566

FLT3N.pep

MetAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGlu LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCys GlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLys MetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProPro ProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal AlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSer SerThrLeuGlyGlyGlySer SEQ ID NO:567

FLT3C.pep

GlySerGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeu GlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeu GluLeuGlnCysGlnProAspSerSerThrLeu SEQ ID NO:568

FLT7N.pep

MetAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGlu LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCys GlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLys MetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProPro ProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal AlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSer SerThrLeuGlyGlyGlySerGlyGlyGlySer SEQ ID NO:569

FLT4C.pep

GlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeu SEQ ID NO:570

FLT11N.pep

MetAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGlu LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCys GlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLys MetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeu GlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeu GluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer SEQ ID NO:571

FLT10C.pep

GlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu ArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPhe ValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeu LeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCys LeuGluLeuGlnCysGlnProAspSerSerThrLeu SEQ ID NO:572

pMON32365.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeuGln SEQ ID NO:573

pMON32366.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGln HisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyr ProValThrValAlaSerAsnLeuGln SEQ ID NO:574

pMON32367.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:575

pMON32368.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThr GlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaVal LysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:576

pMON32369.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:577

pMON32370.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:578

pMON30247.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaProLeuLeuAsp ProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArg AsnLeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGlyIle GluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIl eIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAla GlnGluGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIle AsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrGlnAspCysSerPheGln HisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyr ProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyAlaLeuTrpArgLeuValLeuAla GlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnPro SEQ ID NO:579

pMON30248.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaProLeuLeuAsp ProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeuArgLeuProAsnLeuGlu SerPheValArgAlaValLysAsnLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsn LeuGlnAspGluGluLeuCysGlyAlaLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArg LeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeu GlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeu GluLeuGlnCysGlnProAspSerSerThrLeu SEQ ID NO:580

pMON32332.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaProLeuLeuAsp ProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeuArgLeuProAsnLeuGlu SerPheValArgAlaValLysAsnLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAla GlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlySer GlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:581

pMON32333.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaProLeuLeuAsp ProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeuArgLeuProAsnLeuGlu SerPheValArgAlaValLysAsnLeuGluAsnAlaSerGlyIleGluAlaIleLeu ArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAla GlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGln GlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSer ProProSerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArg PheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrp IleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGly GlyAsnGlySerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPhe AlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:582

pMON32334.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaProLeuLeuAsp ProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeuArgLeuProAsnLeuGlu SerPheValArgAlaValLysAsnLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SEQ ID NO:583

pMON32335.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaProLeuLeuAsp ProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeuArgLeuProAsnLeuGlu SerPheValArgAlaValLysAsnLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsn GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SEQ ID NO:584

pMON32336.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaProLeuLeuAsp ProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeuArgLeuProAsnLeuGlu SerPheValArgAlaValLysAsnLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIle LysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGln GluGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeu TrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGly LeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCys LeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu SerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeuGln SEQ ID NO:585

pMON32337.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaProLeuLeuAsp ProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeuArgLeuProAsnLeuGlu SerPheValArgAlaValLysAsnLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlyThrGlnAspCysSer PheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln AspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuVal LeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro SEQ ID NO:586

pMON32338.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaProLeuLeuAsp ProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeuArgLeuProAsnLeuGlu SerPheValArgAlaValLysAsnLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsnGly ThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSer AspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGly LeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGln GlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro SEQ ID NO:587

pMON32339.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaProLeuLeuAsp ProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeuArgLeuProAsnLeuGlu SerPheValArgAlaValLysAsnLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGln GluGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaProProSerCysLeuArgPheVal GlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsn GlySerGlyGlyAsnGlySerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu ArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPhe ValThrLysCysAlaPheGlnPro SEQ ID NO:588

pMON32364.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsn LeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGl uLeuGlnCysGlnPro SEQ ID NO:589

pMON32377.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsn LeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeu SEQ ID NO:590

pMON32352.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeu TrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGly LeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCys LeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu SerGlyGlyAsnGlySerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSer AspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSer AsnLeuGln SEQ ID NO:591

pMON32353.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAla GlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlySer GlyGlyAsnGlySerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsn LeuGln SEQ ID NO:592

pMON32354.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeu ValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SEQ ID NO:593

pMON32355.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGluArg ValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheVal GlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsn GlySerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaVal LysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp GluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal AlaGly SEQ ID NO:594

pMON32356.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsn GlySerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaVal LysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp GluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal AlaGly SEQ ID NO:595

pMON32357.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlyThrGlnAspCysSer PheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln AspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuVal LeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArg ValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro SEQ ID NO:596

pMON32358.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsn PheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlySerGly GlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeu CysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySer LysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro SEQ ID NO:597

pMON32359.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsnGly SerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLys IleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGlu GluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAla GlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnPro SEQ ID NO:598

pMON32360.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsn LeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGlu AlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIle IleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAla GlnGluGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIle AsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGly LeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGln GlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSer CysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeu LysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuSerGlyGlySerGlySerGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGln SEQ ID NO:599

pMON32362.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAla GlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValG lnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlySer GlySerGlyGlySerGlySerGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGln SEQ ID NO:600

pMON32392.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLys ArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArg AsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIle GluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIle IleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGln AlaGlnGluGlnGln SEQ ID NO:601

pMON32393.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuTyrValGluGlyGlyGlyGlySerProGlyGluProSerGly ProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaAsnCys SerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsn LeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheVal ArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeu ProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArg GluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGln SEQ ID NO:602

pMON32396.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerProHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsn LeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnGluThrSerGluGlnLeuValAlaLeuLysPro TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu SEQ ID NO:603

pMON32371.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAla GlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGly ThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSer AspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:604

pMON32372.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAla GlnGluGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIle AsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGly LeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGln GlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSer CysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeu LysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPhe AlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeu Gln SEQ ID NO:605

pMON32373.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAla GlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGly GlySerGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSer AsnLeuGln SEQ ID NO:606

pMON32374.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAla GlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:607

pMON32375.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeu TrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGly LeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCys LeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeuGln SEQ ID NO:608

pMON32376.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAla GlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeuGln SEQ ID NO:609

pMON32378.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyThrGlnAsp CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeu LeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SEQ ID NO:610

pMON32379.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGlu ArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPhe ValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIle ThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGly SerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SEQ ID NO:611

pMON32380.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGly GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SEQ ID NO:612

pMON32381.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SEQ ID NO:613

pMON32382.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGluArgVal AsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln ThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArg GlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSer AspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSer AsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArg LeuLysThrValAlaGly SEQ ID NO:614

pMON32383.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIle SerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal AlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMet GluArgLeuLysThrValAlaGly SEQ ID NO:615

pMON32384.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeu ValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGlu ArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro SEQ ID NO:616

pMON32385.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaProProSerCysLeuArgPheValGln ThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArg GlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGly GlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGlu LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCys GlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLys MetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro SEQ ID NO:617

pMON32386.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly ThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSer AspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGly LeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGln GlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro SEQ ID NO:618

pMON32387.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeu CysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySer LysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro SEQ ID NO:619

pMON32388.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsn PheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPhe AlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeu GlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnPro SEQ ID NO:620

pMON32389.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu ArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPhe ValThrLysCysAlaPheGlnPro SEQ ID NO:621

hflt3-2829link10.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln SEQ ID NO:622

hflt3-2829link15.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal AlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAla PheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSer GluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCys GlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThr GlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAsp TyrLeuLeuGln SEQ ID NO:623

hflt3-3435link10.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeu LeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu ArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysPro TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGly GlyGlySerGlyGlyGlySerGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal SEQ ID NO:624

hflt3-3435link15.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArg ThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIle LeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLys AlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGlu GlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnPro SerProProSerLysGluSerHisLysSerProAsnMetAlaAlaSerAsnLeuGlnAspGluGluLeu CysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySer LysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro ProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAsp SerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrVal SEQ ID NO:625

hflt3-6263link10.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArg GlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGly GlyGlySerGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLys IleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGlu GluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr SEQ ID NO:626

hflt3-6263link15.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsn LeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThr SEQ ID NO:627

hflt3-9495link10.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIle GluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleI leIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGln AlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThr IleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaArgPheValGlnThrAsn IleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsn PheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGly SerGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeu CysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySer LysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro ProProSerCysLeu SEQ ID NO:628

hflt3-9495link15.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGln CysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGly ThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSer AspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp GluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal AlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAla PheGlnProProProSerCysLeu SEQ ID NO:629

hflt3-9899link10.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlySerSerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAsp SerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyThrGlnAspCysSerPheGlnHisSer ProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal ThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArg TrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGlu IleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln SEQ ID NO:630

hflt3-9899link15.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIle LysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGln GluGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly GlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGlu LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCys GlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLys MetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProPro ProSerCysLeuArgPheValGln SEQ ID NO:631

hflt3-2829link6.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuGlyGlyGlySerGlyGlyThrGlnAspCysSer PheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln SEQ ID NO:632

hflt3-2829link7.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIle SerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln SEQ ID NO:633

hflt3-2829link13.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGln GluGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaAspTyrProValThrValAlaSer AsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArg LeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeu GlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeu GluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGln SEQ ID NO:634

hflt3-2829link21.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr SEQ ID NO:635

hflt3-3435link6.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeu LeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu ArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysPro TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGly GlyGlySerGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLys IleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal SEQ ID NO:636

hflt3-3435link7.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGln GluGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIle SerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal SEQ ID NO:637

hflt3-3435link13.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeu LeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu ArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysPro TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIle SerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln AspTyrProValThrVal SEQ ID NO:638

hflt3-3435link21.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeu LeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu ArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysPro TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAsp CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeu LeuGlnAspTyrProValThrVal SEQ ID NO:639

hflt3-6263link6.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGln GluGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaValAlaGlySerLysMetGlnGly LeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCys LeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu GlyGlyGlySerGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaVal LysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp GluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr SEQ ID NO:640

hflt3-6263link7.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGly GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr SEQ ID NO:641

hflt3-6263link13.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln AspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr SEQ ID NO:642

hflt3-6263link21.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnPro SerProProSerLysGluSerHisLysSerProAsnMetAlaValAlaGlySerLysMetGlnGlyLeu LeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu ArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysPro TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAsp CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeu LeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr SEQ ID NO:643

hflt3-9495link6.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGln CysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyThrGlnAspCysSerPheGlnHisSer ProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal ThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArg TrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGlu IleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu SEQ ID NO:644

hflt3-9495link7.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGln CysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGln ArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThr GluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu SEQ ID NO:645

hflt3-9495link13.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeu SEQ ID NO:646

hflt3-9495link21.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGln CysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaVal LysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp GluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal AlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAla PheGlnProProProSerCysLeu SEQ ID NO:647

hflt3-9899link6.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlySerSerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAsp SerSerThrLeuGlyGlyGlySerGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSer AspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSer AsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArg LeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln SEQ ID NO:648

hflt3-9899link7.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlySerSerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPhe GlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAsp TyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeu AlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgVal AsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln SEQ ID NO:649

hflt3-9899link13.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlySerSerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAsp SerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPhe GlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAsp TyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeu AlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgVal AsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln SEQ ID NO:650

hflt3-9899link21.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAsp SerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGlu LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCys GlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLys MetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProPro ProSerCysLeuArgPheValGln SEQ ID NO:651

GlySerThrMetSerArgLeuProValLeuLeuLeuLeuGlnLeuLeuValArgProAlaMetSer ThrAsnGlnAspLeuProValIleLysCysValLeuIleAsnHisLysAsnAsnAspSerSerValGly LysSerSerSerTyrProMetValSerGluSerProGluAspLeuGlyCysAlaLeuArgProGlnSer SerGlyThrValTyrGluAlaAlaAlaValGluValAspValSerAlaSerIleThrLeuGlnValLeu ValAspAlaProGlyAsnIleSerCysLeuTrpValPheLysHisSerSerLeuAsnCysGlnProHis PheAspLeuGlnAsnArgGlyValValSerMetValIleLeuLysMetThrGluThrGlnAlaGlyGlu TyrLeuLeuPheIleGlnSerGluAlaThrAsnTyrThrIleLeuPheThrValSerIle ArgAsnThrLeuLeuTyrThrLeuArgArgProTyrPheArgLysMetGluAsnGlnAspAlaLeuVal CysIleSerGluSerValProGluProIleValGluTrpValLeuCysAspSerGlnGlyGluSerCys LysGluGluSerProAlaValValLysLysGluGluLysValLeuHisGluLeuPheGlyMetAspIle ArgCysCysAlaArgAsnGluLeuGlyArgGluCysThrArgLeuPheThrIleAspLeuAsnGlnThr ProGlnThrThrLeuProGlnLeuPheLeuLysValGlyGluProLeuTrpIleArgCysLysAlaVal HisValAsnHisGlyPheGlyLeuThrTrpGluLeuGluAsnLysAlaLeuGluGluGlyAsnTyrPhe GluMetSerThrTyrSerThrAsnArgThrMetIleArgIleLeuPheAlaPheValSerSerValAla ArgAsnAspThrGlyTyrTyrThrCysSerSerSerLysHisProSerGlnSerAlaLeuValThrIle ValGluLysGlyPheIleAsnAlaThrAsnSerSerGluAspTyrGluIleAspGlnTyrGluGluPhe CysPheSerValArgPheLysAlaTyrProGlnIleArgCysThrTrpThrPheSerArgLysSerPhe ProCysGluGlnLysGlyLeuAspAsnGlyTyrSerIleSerLysPheCysAsnHisLysHisGlnPro GlyGluTyrIlePheHisAlaGluAsnAspAspAlaGlnPheThrLysMetPheThrLeuAsnIleArg ArgLysProGlnValLeuAlaGluAlaSerAlaSerGlnAlaSerCysPheSerAspGlyTyrProLeu ProSerTrpThrTrpLysLysCysSerAspLysSerProAsnCysThrGluGluIleThrGluGlyVal TrpAsnArgLysAlaAsnArgLysValPheGlyGlnTrpValSerSerSerThrLeuAsnMetSerGlu AlaIleLysGlyPheLeuValLysCysCysAlaTyrAsnSerLeuGlyThrSerCysGluThrIleLeu LeuAsnSerProGlyProPheProPheIleGlnAspAsnGluPheIleIleLeuGlyLeuPheGlyLeu LeuLeuLeuLeuThrCysLeuCysGlyThrAlaTrpLeuCysCysSerProAsnArgLysAsnProLeu TrpProSerValProAspProAlaHisSerSerLeuGlySerTrpValProThrIleMetGluGluAsp AlaPheGlnLeuProGlyLeuGlyThrProProIleThrLysLeuThrValLeuGluGluAspGluLys LysProValProTrpGluSerHisAsnSerSerGluThrCysGlyLeuProThrLeuValGlnThrTyr ValLeuGlnGlyAspProArgAlaValSerThrGlnProGlnSerGlnSerGlyThrSerAspGlnVal LeuTyrGlyGlnLeuLeuGlySerProThrSerProGlyProGlyHisTyrLeu ArgCysAspSerThrGlnProLeuLeuAlaGlyLeuThrProSerProLysSerTyrGluAsnLeuTrp PheGlnAlaSerProLeuGlyThrLeuValThrProAlaProSerGlnGluAspAspCysValPheGly ProLeuLeuAsnPheProLeuLeuGlnGlyIleArgValHisGlyMetGluAlaLeuGlySerPhe SEQ ID NO:652

pMON30329.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerPro AsnMetAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeu CysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySer LysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro ProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAsp SerSerThrLeu SEQ ID NO:653

pMON32173.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer ThrLeuTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnPro SerProProSerLysGluSerHisLysSerProAsnMetAlaThrGlnAspCysSerPheGlnHisSer ProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal ThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArg TrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGlu IleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIle SerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPhe SerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu SEQ ID NO:654

pMON32175.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer ThrLeuTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIle SerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGly ProAlaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAsp GlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeu GlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGly CysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSer ProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGln GlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSer AlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyr ArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:655

pMON32204.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerPro AsnMetAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeu CysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySer LysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuTyrValGluGlyGlyGlyGlySerProGlyGluProSerGly ProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrGln AspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyr LeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeu LeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu ArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysPro TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu SEQ ID NO:656

pMON32205.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaProLeuLeuAsp ProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeuArgLeuProAsnLeuGlu SerPheValArgAlaValLysAsnLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsn LeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIle SerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPhe SerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuTyrValGluGlyGlyGlyGlySer ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSer ProAsnMetAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeu SEQ ID NO:657

pMON32208.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer ThrLeuTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnPro SerProProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeu ProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGln GluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGly IleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGly CysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSer ProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGln GlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSer AlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyr ArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerProGlyGluProSerGly ProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrGln AspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyr LeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeu LeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu ArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysPro TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu SEQ ID NO:658

pMON35767.pep/pMON32191.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer ThrLeuTyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGlyGlySerAsnMetAlaThr ProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnVal ArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisPro GluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGln AlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGln AlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPhe AlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAla MetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSer PheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:659

pMON32397.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln SEQ ID NO:660

pON32398.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAsp CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeu LeuGln SEQ ID NO:661

pMON32399.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAlaSerAsnLeuGlnAspGluGluLeu CysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySer LysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro ProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAsp SerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyThrGlnAspCysSerPheGlnHisSer ProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal ThrVal SEQ ID NO:662

pMON35700.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeu LeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu ArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysPro TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSer ProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal ThrVal SEQ ID NO:663

pMON35701.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGly GlySerGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr SEQ ID NO:664

pMON35702.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPhe ValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIle ThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGly SerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIle SerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal AlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMet GluArgLeuLysThr SEQ ID NO:665

pMON35703.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGln CysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyThrGlnAspCysSer PheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln AspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuVal LeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArg ValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu SEQ ID NO:666

pMON35704.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThr ProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeu ArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAla GlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGln GlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSer ProProSerLysGluSerHisLysSerProAsnMetAlaArgPheValGlnThrAsnIleSerArgLeu LeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCys LeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeu SEQ ID NO:667

pMON35705.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlySerSerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAsp SerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGln ArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThr GluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln SEQ ID NO:668

pMON35706.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAsp SerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeu ValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGlu ArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPhe ValGln SEQ ID NO:669

pMON35733.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIle LeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLys AlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGlu GlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnPro SerProProSerLysGluSerHisLysSerProAsnMetAlaSerAsnLeuGlnAspGluGluLeuCys GlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLys MetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProPro ProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal AlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSer SerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAla SEQ ID NO:670

pMON35734.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeu ValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGlu ArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArg PheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrp IleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSer SEQ ID NO:671

pMON35735.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuVal LeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArg ValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheVal GlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPhe GlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAsp TyrProValThrValAlaSerAsn SEQ ID NO:672

pMON35736.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeu AlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgVal AsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln ThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArg GlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGln HisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyr ProValThrValAlaSerAsnLeu SEQ ID NO:673

pMON35738.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaGluGluLeuCysGlyGlyLeuTrpArgLeu ValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGlu ArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPhe ValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIle ThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGly SerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSer PheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln AspTyrProValThrValAlaSerAsnLeuGlnAsp SEQ ID NO:674

pMON35739.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArg TrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGlu IleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIle SerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPhe SerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerPro IleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThr ValAlaSerAsnLeuGlnAspGlu SEQ ID NO:675

pMON35740.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrp MetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIle SerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal AlaSerAsnLeuGlnAspGluGlu SEQ ID NO:676

pMON35741.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGln GluGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaSerAsnLeuGlnAspGluGluLeu CysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySer LysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro ProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAsp SerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspSerAlaValLysIleArgGlu LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SEQ ID NO:677

pMON35742.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeu AlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgVal AsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln ThrAsnIleSerArgLeuLeuArgGluThrSerGluGlnProValAlaLeuLysProTrpIleThrArg GlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThr GlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAsp TyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeu SEQ ID NO:678

pMON35743.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGlu GlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrp MetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysArgProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIle SerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal AlaSerAsnLeuGlnAspGluGlu SEQ ID NO:679

pMON32179.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIle SerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPhe SerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerPro IleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThr ValTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSer ProProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIle HisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIle LeuMetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsn AlaSerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuVal ThrLeuGluGlnAlaGlnGluGlnGln SEQ ID NO:680

pMON35707.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuArgProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGlu ProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMet AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIle LeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLys AlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGlu GlnGln SEQ ID NO:681

pMON35708.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProPro AsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArg ThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIle LeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLys AlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGlu GlnGln SEQ ID NO:682

pMON35709.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIle SerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal AlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThr IleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIle AspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGlu AspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLys HisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThr AlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGln SEQ ID NO:683

pMON35710.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgLeuValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProPro AsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArg ThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSer GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHis ProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeu GluGlnAlaGlnGluGlnGln SEQ ID NO:684

pMON35711.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlyArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHis HisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeu MetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAla SerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArg HisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThr LeuGluGlnAlaGlnGluGlnGln SEQ ID NO:685

pMON35719.pep

MetAlaAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProPro ProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal AlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSer SerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSer PheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHis HisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeu MetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAla SerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArg HisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThr LeuGluGlnAlaGlnGluGlnGln SEQ ID NO:686

pMON35720.pep

AlaAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrp MetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaVal LysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProPro AsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArg ThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSer GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHis ProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeu GluGlnAlaGlnGluGlnGln SEQ ID NO:687

pMON35721.pep

AlaValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProPro AsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArg ThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIle LeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLys AlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGlu GlnGln SEQ ID NO:688

pMON35722.pep

AlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGln ProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly GlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGlu LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCys GlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlyTyrVal GluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSer LysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeu LysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGlu ArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGly IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisPro IleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGlu GlnAlaGlnGluGlnGln SEQ ID NO:689

pMON35723.pep

AlaProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAsp CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeu LeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProPro AsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArg ThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIle LeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHis ProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeu GluGlnAlaGlnGluGlnGln SEQ ID NO:690

pMON35725.pep

AlaThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu ArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPhe ValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProPro AsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArg ThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIle LeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLys AlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGlu GlnGln SEQ ID NO:691

pMON35726.pep

AlaArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysPheTyr ValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProPro SerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHisHis LeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMet GluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSer GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHis ProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeu GluGlnAlaGlnGluGlnGln SEQ ID NO:692

pMON35744.pep

AlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMet GluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis PheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHis HisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeu MetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAla SerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArg HisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGln SEQ ID NO:693

pMON35745.pep

AlaAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu ArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPhe ValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeu LeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCys LeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSer AspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSer TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHis HisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeu MetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAla SerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArg HisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThr LeuGluGlnAlaGlnGluGlnGln SEQ ID NO:694

pMON35746.pep

AlaLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgLeuMetGluArg LeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeu GlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsn PheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSer ProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal ThrValAlaSerAsnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThr IleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIle AspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGlu AspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLys HisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThr AlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGln SEQ ID NO:695

pMON35747.pep

AlaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPhe AlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeu TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHis HisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeu MetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLys HisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThr AlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGln SEQ ID NO:696

pMON35748.pep

AlaGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr ValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCys AlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGln CysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaVal LysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHis HisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeu MetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAla SerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArg HisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThr LeuGluGlnAlaGlnGluGlnGln SEQ ID NO:697

pMON35749.pep

AlaLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAla GlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeu GlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeu GluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsn LeuGlnAspGluGluTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThr IleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIle AspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGlu AspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLys HisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThr AlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGln SEQ ID NO:698

pMON35750.pep

AlaLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAla GlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGln ProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGlu IleIleHisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMet AspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeu GluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAla ProSerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyr LeuValThrLeuGluGlnAlaGlnGluGlnGln SEQ ID NO:699

pMON35769.pep

AlaLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAla GlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysArg ProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHis HisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeu MetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAla SerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArg HisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThr LeuGluGlnAlaGlnGluGlnGln SEQ ID NO:700

pMON35771.pep

AlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGln ProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGln AspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyr LeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlyTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProPro AsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArg ThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIle LeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLys AlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGlu GlnGln SEQ ID NO:701

pMON35774.pep

AlaGlnAspAspGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGln HisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeu LeuGlnAspTyrProValThrValAlaSerAsnLeuTyrValGluGlyGlyGlyGlySerProGlyGlu ProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMet AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAsnProLeuLeuAsp ProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeu AlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGln SEQ ID NO:702

pMON35775.pep

AlaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeuProProProTrpSerProArgProLeuGlyAlaThrAla ProThrThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGlu LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProPro AsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArg ThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIle LeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLys AlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGlu GlnGln SEQ ID NO:703

pMON35776.pep

AlaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeuProProProTrpSerProArgProLeuGlyAlaThrAla ProThrAlaGlyGlnProProLeuThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPhe AlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeu TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHis HisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeu MetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAla SerGlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArg HisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThr LeuGluGlnAlaGlnGluGlnGln SEQ ID NO:704

pMON32169.pep/pMON40000.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnPro ThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSer HisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGly GlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu SerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGln ArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThr GluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsn IleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsn PheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSer ProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal ThrValAlaSerAsnLeuGln SEQ ID NO:705

pMON32188.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerPro AsnMetAlaAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrp MetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArg ValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheVal GlnIleAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPhe GlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAsp TyrProValThrValAlaSer SEQ ID NO:706

pMON32273.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerPro AsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSer GluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCys GlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLys IleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGlu GluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnPro SEQ ID NO:707

pMON35795.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerPro AsnMetAlaLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMet GluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis PheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsn SEQ ID NO:708

pMON35796.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLys LeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSer CysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGln GlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAsp ValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnPro ThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSer HisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGly GlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu SerHisLysSerProAsnMetAlaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAla GlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeu SEQ ID NO:709

pMON35797.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThr GlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHis LeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGly GlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer HisLysSerProAsnMetAlaGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrp MetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIle SerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal AlaSerAsnLeuGlnAsp SEQ ID NO:710

pMON35798.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerPro AsnMetAlaGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis PheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGlnAspGlu SEQ ID NO:711

pMON35799.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerPro AsnMetAlaLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr ValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCys AlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGln CysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSer AspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSer AsnLeuGlnAspGluGlu SEQ ID NO:712

pMON39914.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerPro AsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArg LeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeu GlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeu GluLeuGlnCysGlnProAspSerSerThrLeuProProProTrpSerProArgProLeuGlyAlaThr AlaProThrThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:713

pMON39915.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeu CysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCys ProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGly LeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspVal AlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThr GlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHis LeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGly GlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer HisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArg TrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGlu IleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIle SerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPhe SerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGln AspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyr LeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:714

pMON39916.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThr GlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHis LeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGly GlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer HisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArg TrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGlu IleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIle SerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPhe SerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuProProProTrpSerProArgPro LeuGlyAlaThrAlaProThrAlaGlyGlnProProLeuThrGlnAspCysSerPheGlnHisSerPro IleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThr ValAlaSerAsnLeuGln SEQ ID NO:715

pMON35712.pep

AlaAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeu ValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGlu ArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPhe ValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIle ThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGly SerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIle SerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln SEQ ID NO:716

pMON35713.pep

AlaAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrp MetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArg ValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheVal GlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal SEQ ID NO:717

pMON35714.pep

AlaValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr SEQ ID NO:718

pMON35715.pep

AlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGln ProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGln AspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyr LeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCys GlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SEQ ID NO:719

pMON35716.pep

AlaProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAsp CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeu LeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro SEQ ID NO:720

pMON35717.pep

AlaArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGln ArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThr GluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu SEQ ID NO:721

pMON35718.pep

AlaThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGln ArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThr GluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln SEQ ID NO:722

pMON32170.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGln SerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLys LeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIlePro TrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSer GlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeu AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMet AlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGln ArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeu ArgHisLeuAlaGlnPro SEQ ID NO:723

pMON32187.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGln SerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLys LeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIlePro TrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSer GlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeu AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMet AlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGly GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAla GlnPro SEQ ID NO:724

pMON32271.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis PheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuProProProTrpSerProArgProLeuGly AlaThrAlaProThrAlaGlyGlnProProLeuThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuTyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGlyGlySerAsnMetAla ThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLys IleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGlu LeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeu GlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeu GluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThr ThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetPro AlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeu GluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:725

pMON32272.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGly GlySerGlyGlyGlySerAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeu LeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAla ThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaPro LeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPhe LeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeu GlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAla LeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeu ValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:726

pMON32274.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuProProProTrpSerProArgProLeuGlyAlaThrAlaPro ThrThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuTyrValGluGlyGlyGlyGly SerProGlyGlyGlySerGlyGlyGlySerAsnMetAlaThrProLeuGlyProAlaSerSerLeuPro GlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGlu LysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIle ProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHis SerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerPro GluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGln MetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAla PheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArg ValLeuArgHisLeuAlaGlnPro SEQ ID NO:727

pMON35751.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuArgProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGlu ProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMet AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:728

pMON35752.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysCys LeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLys LeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSer CysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGln GlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAsp ValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnPro ThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSer HisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:729

pMON35753.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerAr gCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIle AsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSer SerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAla LeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSer LeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSer GlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeu GlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGlu GluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGln ArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValVal ArgHisLeuAlaGlnPro SEQ ID NO:730

pMON35754.pep

AlaProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGln LeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAsp CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeu LeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu SerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerValProGlnSerPheLeuLeu LysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThr TyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeu SerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeu TyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGln LeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeu GlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuVal AlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValIleArgHisLeuAlaGlnPro SEQ ID NO:731

pMON35755.pep

AlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMet GluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis PheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerHis ProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGln SerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLys LeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIlePro TrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSer GlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeu GlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGlu GluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGln ArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeu ArgHisLeuAlaGlnPro SEQ ID NO:732

pMON35756.pep

AlaAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu ArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPhe ValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeu LeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCys LeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSer AspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSer TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGln SerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLys LeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIlePro TrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSer GlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeu AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMet AlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGly GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValIleArgHisLeuAla GlnPro SEQ ID NO:733

pMON35757.pep

AlaLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgLeuMetGluArg LeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeu GlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeu GluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsn TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGln SerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLys LeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIlePro TrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSer GlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeu AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMet AlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGly GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAla GlnPro SEQ ID NO:734

pMON35758.pep

AlaLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAla GlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeu GluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsn LeuGlnAspGluGluTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThr IleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAla SerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAla AlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHis SerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeu SerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGlu LeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMet GluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPhe GlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgVal LeuArgHisLeuAlaGlnPro SEQ ID NO:735

pMON35759.pep

AlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGln ProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGln AspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyr LeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlyTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLys GluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeu LeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAla ThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaPro LeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPhe LeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeu GlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAla LeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeu ValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:736

pMON35760.pep

AlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGln ProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGln AspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyr LeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlyTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysCys LeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLys LeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSer CysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGln GlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAsp ThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAla ProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGly ValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGln Pro SEQ ID NO:737

pMON35761.pep

AlaLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAla GlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysArg ProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAsnPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIlePheThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGln SerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLys LeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIlePro TrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSer GlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeu AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMet AlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGly GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAla GlnPro SEQ ID NO:738

pMON35762.pep

AlaGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal AlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAla PheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSer GluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCys GlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLys IleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGlu TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGln SerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLys LeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIlePro TrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSer GlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeu AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMet AlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGly GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAla GlnPro SEQ ID NO:739

pMON35763.pep

AlaGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr ValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCys AlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGlnAspTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThr IleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAla SerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAla AlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHis SerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeu SerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGlu LeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMet GluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPhe GlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgVal LeuArgHisLeuAlaGlnPro SEQ ID NO:740

pMON35764.pep

AlaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPhe AlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeu TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSer LeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeu GlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeu GlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGln LeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGly ProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGlu LeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArg ArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArg HisLeuAlaGlnPro SEQ ID NO:741

pMON35765.pep

AlaThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu ArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPhe ValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysCys LeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLys LeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSer CysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGln GlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThr LeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaPro AlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyVal LeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:742

pMON35766.pep/pMON32190.pep/pMON40001.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln TyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGlyGlySerAsnMetAlaThrProLeu GlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGly AspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeu LeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAla GlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIle SerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrp GlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAla SerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSer TyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:743

pMON35768.pep

AlaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspSer AlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeu TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGln SerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLys LeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIlePro TrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSer GlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeu AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMet AlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGly GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAla GlnPro SEQ ID NO:744

pMON35770.pep

AlaLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAla GlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysTyrAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeu GluLeuGlnCysArgProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysI leArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGlu GluTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSer ProProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuPro GlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGlu LysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIle ProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHis SerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThr LeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGly MetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAla GlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeu AlaGlnPro SEQ ID NO:745

pMON35772.pep

AlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPhePheArgCysLeuGluLeuGlnCysGln ProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGln AspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyr LeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlyTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu SerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeu LysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThr TyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeu SerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeu TyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGln LeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeu GlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuVal AlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:746

pMON35773.pep

AlaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGln HisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyr ProValThrValAlaSerAsnLeuTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyPro IleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrProLeu GlyProAlaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGly AspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeu LeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAla GlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGln AlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPhe AlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAla MetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSer PheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:747

pMON35777.pep

AlaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeuProProProTrpSerProArgProLeuGlyAlaThrAla ProThrThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGlu LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysCys LeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLys LeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSer CysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGln GlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAsp ValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnPro ThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSer HisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:748

pMON35778.pep

AlaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeuProProProTrpSerProArgProLeuGlyAlaThrAla ProThrAlaGlyGlnProProLeuThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPhe AlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeu TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGln SerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLys LeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIlePro TrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSer GlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeu AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMet AlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGly GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAla GlnPro SEQ ID NO:749

pMON35779.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGlu ProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMet AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:750

pMON35780.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgProLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHis SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSer GlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThr ProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIle GlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeu ValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGln LeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGlu GlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThr IleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAla PheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGlu ValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:751

pMON35782.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuProProProTrpSerProArgProLeuGlyAlaThrAlaPro ThrAlaGlyGlnProProLeuThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln TyrValGluGlyGlyGlyGlyThrProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGln SerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLys LeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIlePro TrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSer GlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGlu LeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMet GluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPhe GlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgVal LeuArgHisLeuAlaGlnPro SEQ ID NO:752

pMON39908.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProValGluThrValPheHisArgValSerGlnAspGlyLeuAspLeuLeuThrSerThr GlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAsp TyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySer ProGlyGlyGlySerGlyGlyGlySerAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGln SerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLys LeuCysAlaThrAsnLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIlePro TrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSer GlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeu AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMet AlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGly GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAla GlnPro SEQ ID NO:753

pMON32275.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuTyrValGluGlyGlyGlyGlySerProGlyGluProSerGly ProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrPro LeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGln GlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuVal LeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeu AlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGly IleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIle TrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPhe AlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluVal SerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerProGlyGluPro SerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAla ThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSer AspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:754

pMON35781.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnGluProLysSerProAsp ThrHisThrSerProProSerProThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeu LysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGlu LysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIle ProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHis SerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThr LeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGly MetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAla GlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeu AlaGlnProSerAlaGluProLysSerProAspThrHisThrSerProProSerProGlySerAsnLeu GlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeu SEQ ID NO:755

pMON35783.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyTrpGlnGlyArgValAsnThrGluIleHisPheValThrLysCysAlaPheProLysSerPro AspThrHisThrSerProProSerProGlyThrProLeuGlyProAlaSerSerLeuProGlnSerPhe LeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCys AlaTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaPro LeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPhe LeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThr LeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaPro AlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyVal LeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SerAlaGluProLysSerProAspThrHisThrSerProProSerProGlyLysAlaPheGlnProPro ProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal AlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSer SerThrLeu SEQ ID NO:756

pMON32276.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys SerAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspSerSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln TyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGlyGlySerAsnMetAlaThrProLeu GlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGly AspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrAsnLysLeuCysHisProGluGluLeuValLeu LeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAla GlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIle SerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrp GlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAla SerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:757

pMON32277.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerPro AsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArg LeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal ThrLysSerAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeu GlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeu GluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyThrGlnAspSerSerPheGlnHisSerProIleSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsn LeuGln SEQ ID NO:758

pMON32278.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis PheValThrLysCysAlaPheGlnProProProSerSerLeuArgPheValGlnThrAsnIleSerArg LeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnSerGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGlyGlySerAsnMet AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrAsnLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:759

pMON32279.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThr GlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHis LeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGly GlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer HisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArg TrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGlu IleHisPheValThrLysCysAlaPheGlnProProProSerSerLeuArgPheValGlnThrAsnIle SerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPhe SerArgCysLeuGluLeuGlnSerGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerPro IleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThr ValAlaSerAsnLeuGln SEQ ID NO:760

pMON35790.pep

AlaThrGlnAspSerSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysSerAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer ThrLeuTyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGlyGlySerAsnMetAlaThr ProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIle GlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrAsnLysLeuCysHisProGluGluLeu ValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGln LeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeu GlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAsp PheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGly AlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGln SerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:761

pMON35791.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerSerLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnSerGlnProAspSerSer ThrLeuTyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGlyGlySerAsnMetAlaThr ProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIle GlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrAsnLysLeuCysHisProGluGluLeu ValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGln LeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGlu GlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThr IleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAla PheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGlu ValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:762

pMON35792.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnTyrValGluGlyGlyGly GlySerProGlyGlyGlySerGlyGlyGlySerAsnMetAlaThrProLeuGlyProAlaSerSerLeu ProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGln GluLysLeuCysAlaThrAsnLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGly IleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeu HisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyPro ThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeu GlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArg AlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHis LeuAlaGlnPro SEQ ID NO:763

pMON39905.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnSer GlnProAspSerSerThrLeuTyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGlyGly SerAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGlu GlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCys HisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysPro SerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeu LeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAla AspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGln GlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeu GlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO:764

pMON39906.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro SerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpIleThrArgGlnAsnPheSerArgArgLeuGluLeuGlnSerGlnProAspSerSer ThrLeuTyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGlyGlySerAsnMetAlaThr ProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIle GlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrAsnLysLeuCysHisProGluGluLeu ValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGln LeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGlu GlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAla AspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGln GlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeu GlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPr SEQ ID NO:765

pMON39909.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln TyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGlyGlySerAsnMetAlaThrGlnGly AlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGln SerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProSerGlyGlySerGlyGlySer GlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGlu LysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIle ProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHis SerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThr LeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGly MetAlaProAlaLeuGlnPro SEQ ID NO:766

pMON39910.pep

AlaThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAla SerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProSerGlyGly SerGlyGlySerGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAla AlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHis SerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeu SerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGlu LeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMet GluGluLeuGlyMetAlaProAlaLeuGlnProTyrValGluGlyGlyGlyGlySerProGlyGluPro SerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAla AspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr ValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCys AlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGln CysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaVal LysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:767

pMON35727.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLys IleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnTyrVal GluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSer LysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeu AlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgVal AsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln ThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArg GlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIleSerSer AspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSer AsnLeuGln SEQ ID NO:768

pMON32168.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro ProSerLysGluSerHisLysSerProAsnMetAlaThrGlnAspCysSerPheGlnHisSerProIle SerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAsnTyrProValThrVal AlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAla GlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu SEQ ID NO:769

pMON32195.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln TyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGlyGlySerAsnMetAlaThrProLeu GlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGly AspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeu LeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAla GlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIle SerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrp GlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAla SerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSer TyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySer ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSer ProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu ArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPhe ValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeu LeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCys LeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSer AspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSer AsnLeuGln SEQ ID NO:770

pMON32196.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerPro AsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArg LeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeu GlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsn PheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSer ProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal ThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIle SerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeu ValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGlu ArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPhe ValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIle ThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu SEQ ID NO:771

pMON32197.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArg LysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlu GluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAla LeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAla LeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSer ProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu ArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPhe ValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeu LeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCys LeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSer AspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSer AsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeu TrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGly LeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCys LeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGln AspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyr LeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:772

pMON32206.pep

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaProLeuLeuAsp ProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeuArgLeuProAsnLeuGlu SerPheValArgAlaValLysAsnLeuGluAsnAlaSerGlyIleGluAlaIleLeuArgAsnLeuGln ProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLysAlaGlyAspTrpGln GluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGln GlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSer ProProSerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArg PheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrp IleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGlu ProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMet AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO:773

pMON32207.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSer ArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIle SerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal AlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGlyGlySerAsn MetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThr LysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPhe AlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeu GlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSer ProProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuPro GlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGlu LysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIle ProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHis SerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThr LeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGly MetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAla GlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeu AlaGlnProSTPSTPGlySerGluPheGlySer SEQ ID NO:774

pMON35728.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProPro AsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeuArg ThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlyIleGluAlaIle LeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProIleIleIleLys AlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGlu GlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnPro SerProProSerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeu LeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeu ArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysPro TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGly GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSer ProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal ThrValAlaSerAsnLeuGln SEQ ID NO:775

pMON32183.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLys ThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla ValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln GluPheLysLeuGluProArgGlyProThrIleLysProCysProProCysLysCysProAlaProAsn LeuLeuGlyGlyProSerValPheIlePheProProLysIleLysAspValLeuMetIleSerLeuSer ProIleValThrCysValValValAspValSerGluAspAspProAspValGlnIleSerTrpPheVal AsnAsnValGluValHisThrAlaGlnThrGlnThrHisArgGluAspTyrAsnSerThrLeuArgAla ValSerAlaLeuProIleGlnHisGlnAspTrpMetSerGlyLysGluPheLysCysLysValAsnAsn LysAspLeuProAlaProIleGluArgThrIleSerLysProLysGlySerValArgAlaProGlnVal TyrValLeuProProProGluGluGluMetThrLysLysGlnValThrLeuThrCysMetValThrAsp PheMetProGluAspIleTyrValGluTrpThrAsnAsnGlyLysThrGluLeuAsnTyrLysAsnThr GluProValLeuAspSerAspGlySerTyrPheMetTyrSerLysLeuArgValGluLysLysAsnTrp ValGluArgAsnSerTyrSerCysSerValValHisGluGlyLeuHisAsnHisHisThrThrLysSer PheSerArgThrProGlyLys SEQ ID NO:776

pMON32184.pep

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAla GlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGlu GlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGln ProAspSerSerThrLeuGluPheLysLeuGluProArgGlyProThrIleLysProCysProProCys LysCysProAlaProAsnLeuLeuGlyGlyProSerValPheIlePheProProLysIleLysAspVal LeuMetIleSerLeuSerProIleValThrCysValValValAspValSerGluAspAspProAspVal GlnIleSerTrpPheValAsnAsnValGluValHisThrAlaGlnThrGlnThrHisArgGluAspTyr AsnSerThrLeuArgAlaValSerAlaLeuProIleGlnHisGlnAspTrpMetSerGlyLysGluPhe LysCysLysValAsnAsnLysAspLeuProAlaProIleGluArgThrIleSerLysProLysGlySer ValArgAlaProGlnValTyrValLeuProProProGluGluGluMetThrLysLysGlnValThrLeu ThrCysMetValThrAspPheMetProGluAspIleTyrValGluTrpThrAsnAsnGlyLysThrGlu LeuAsnTyrLysAsnThrGluProValLeuAspSerAspGlySerTyrPheMetTyrSerLysLeuArg ValGluLysLysAsnTrpValGluArgAsnSerTyrSerCysSerValValHisGluGlyLeuHisAsn HisHisThrThrLysSerPheSerArgThrProGlyLys SEQ ID NO:777

다음 실시예에 의해 본 발명을 더 상세히 예시하나 본 발명이 이들 특정 실시예에 한정되지 않음은 물론이다.

실시예 1

모 BHK 발현 벡터의 구성

A. 포유동물의 발현 플라스미드로부터의 AflIII 부위의 제거.

프레임 내에 그리고 hIL-3 수용체 아고니스트 pMON13146(WO 94/12638) 유전자에 대해 3'에 NcoI-HindIII 또는 AflIII-HindIII 유전자 단편을 수용하고 마우스 IgG2b 링커 단편을 수용하도록 새로운 포유동물의 발현 벡터를 구성하였다. 먼저, 단일 AflIII 부위를 pMON3359의 유도체인 pMON3934로부터 제거하였다. pMON3359는 포유동물의 발현 카세트를 함유하는 pUC18-계 벡터이다. 이 카세트는 헤르페스 심플렉스 바이러스 프로모터 IE110(-800 내지 +120) 다음에 변형된 사람 IL-3 신호 펩티드 서열 및 pUC18 폴리링커로 서브클로닝된 SV40 후기 폴리아데닐화(폴리-A)신호를 포함한다(Hippenmeyer et al., Bio/Technology, 1993, pp.1037-1041 참조). 세포 밖으로 유전자 생성물을 분비하는 것을 용이하게 하는, 변형된 사람 IL-3 신호 서열의 측면에 5' 말단 상의 BamHI 부위 및 3' 말단 상의 독특한 NcoI 부위가 위치한다. 독특한 HindIII 부위는 NcoI 부위에 대해 3'이고, 폴리-A 서열에 대해 5'이다. 신호 펩티드를 암호화는 DNA 서열은 아래에 도시되어 있다(제한효소 부위는 위에 나타나 있다). NcoI 부위 내의 ATG(메티오닌) 코돈은 신호 펩티드의 개시제 ATG를 갖는 프레임 내에 있다(밑줄 친 부분);

BamHI NcoI

5' GGATCCACCATGAGCCGCCTGCCCGTCCTGCTCCTGCTCCAACTCCTGGTCCGCCCCGCCATGG

(SEQ ID NO:857)

DNA 폴리메라제 및 뉴클레오티드의 첨가에 의한 오버행 내를 충전하기 전의 AflIII으로의 분해에 의해 pMON3934로부터 단일 AflIII 부위를 제거하였다. 분해된 DNA 단편을 Magic PCR Clean up 키트(Promega)에 의해 정제하고, T4 DNA 리가제에 의해 라이게이션하였다. 라이게이션 반응물을 DH5α^TM으로 형질전환하고, 세포를 LB-한천 및 암피실린 상에 플레이팅하였다. 만약 AflIII 부위가 제거된다면 단일 단편이 되는 AflIII 및 HindIII에 의한 제한 분석에 의해 AflIII 부위의 상실에 대해 개별 콜로니들을 스크리닝하였다. 결과되는 플라스미드를 pMON30275로 표시하였다.

B. hIL-3 수용체 아고니스트 pMON13416/IgG2b 카세트의 pMON30275로의 전달.

pMON30245로부터의 NcoI-HindIII 단편(약 425 bp)을 pMON30275의 NcoI-HindIII 단편(약 3800 bp)으로 라이게이션하였다. pMON30245(WO 94/12638)는 마우스 IgG2b 힌지 단편에 대해 결합된 hIL-3 수용체 아고니스트 pMON13416을 코딩하는 유전자를 함유한다. IgG2b 힌지에 대한 인접 3'에 그리고 HindIII 부위에 대한 5'에 AflIII 부위가 있다. 유전자는 hIL-3 변이체 pMON13416/IgG2b 힌지에 의해 프레임 내의 NcoI-HindIII 또는 AflIII-HindIII 단편으로서 AflIII-HindIII 부위 내에 클로닝되어 신규 키메라를 만들 수 있다. NcoI 부위 및 AflIII 부위는 화합성 오버행를 갖고 라이게이션하지만, 양쪽 인식 부위는 상실된다. 이 클로닝의 결과로서, (SEQ ID NO:1)의 DNA 서열을 함유하고, 마우스 IgG2b 힌지 영역과 결합된 hIL-3 변이 pMON13416을 코딩하는 플라스미드, pMON30304를 얻었다.

실시예 2

다이머 주형의 c-mpl 리간드 (1-153) 유전자의 1개 카피를 함유하는 중간 플라스미드의 구성

독특한 EcoRI 제한 부위 이전의 c-mpl (1-153)의 코딩 서열을 갖는 플라스미드 DNA를 생성하기 위하여, 역전사효소/폴리머라제 연쇄반응(RT/PCR)에 의해 유전자를 분리한다. 사람 태아(로트 #38130) 및 성인 간(로트 #46018) A+ RNA를 c-mpl 리간드 전령 RNA(mRNA)의 공급원을 위해 Clontech(Palo Alto, CA)로부터 얻는다. Invitrogen(San Diego, CA)로부터 얻은 cDNA Cycle^TM 키트를 사용하여 제 1 스트랜드 cDNA 반응을 수행한다. RT 반응에서, 랜덤 프라이머 및 올리고 dT 프라이머는 사람 및 태아 간 mRNA의 조합으로부터 cDNA를 생성하는데 사용된다. 아미노산 1-153을 암호화하는 c-mpl 리간드 유전자 단편의 증폭을 위해, RT 생성물은 프라이머들의 조합인, 포워드 프라이머:c-mplNcoI(SEQ ID NO:317) 및 리버스 프라이머:Ecompl을 갖는 PCR을 위한 주형의 기능을 한다. c-mplNcoI 프라이머는 c-mpl 리간드 유전자(유전자 은행 취득물 #L33410으로부터의 c-mpl 리간드 서열 또는 de Sauvage et al., Nature 369: 533-538(1994)에 근거한 염기 #279-311)로 어닐링되고, c-mpl 리간드의 제 1 코돈 (Ser+1)에 대한 인접 5'에 NcoI 제한효소 부위를 암호화한다. NcoI 제한효소 부위는 Ser+1 이전의 메티오닌 및 알라닌 코돈을 코딩하고, Ala 코돈 및 c-mpl 리간드의 최초 4개의 코돈(Ser, Pro, Ala, & Pro)을 위한 코돈 축퇴를 포함한다. Ecompl 프라이머는 c-mpl 리간드의 염기 #720-737로 어닐링되고, Arg-153 직후의 c-mpl 리간드 유전자를 갖는 프레임 내의 EcoRI 부위(GAATTC)를 암호화한다. EcoRI 부위는 Arg-153 후의 Glu 및 Phe 코돈을 만든다. 약 480 bp PCR 생성물을 정제하고, NcoI 및 EcoRI에 의해 분해하고, pMON3993의 NcoI-EcoRI 벡터 단편에 라이게이션하였다(약 4550 bp.). pMON3993은 pMON3359(실시예 1에 기술됨)의 유도체였다. BamHI 단편으로서 IE110 프로모터와 폴리-A 신호 사이의 독특한 BamHI 부위 내에 서브클로닝된 사람 IL-3 신호 펩티드 서열은 3'말단에 NcoI 부위를 함유하고, 독특한 EcoRI 부위 전에 있다. 이 클로닝의 결과로서, (SEQ ID NO:2)의 DNA 서열을 함유하고, c-mpl 리간드 아미노산 1-153(SEQ ID NO:467)을 코딩하는 플라스미드, pMON26458을 얻었다.

실시예 3

다이머 주형의 제 2 유전자를 함유하는 모 플라스미드의 구성

아미노산 153(Arg) 다음의 종결코돈을 갖는 아미노산 1(Ser)에서 출발하는 c-mpl 리간드 유전자 단편의 증폭을 위해, 실시예 2로부터의 RT 반응은 다음의 프라이머의 조합을 갖는 PCR을 위한 주형의 기능을 한다; c-mplNcoI(SEQ ID NO:317)(포워드 프라이머) 및 c-mplHindIII(SEQ ID NO:319)(리버스 프라이머). c-mplNcoI(SEQ ID NO:317) 프라이머는 실시예 2에 기술되어 있다. c-mpl 리간드의 염기 #716-737로 어닐링되는 c-mplHindIII(SEQ ID NO:319) 프라이머는 최종 코돈인 Arg¹⁵³ 직후의 HindIII 제한효소 부위와 종결코돈 모두를 가한다.

2가지 타입의 PCR 생성물은 RT cDNA 샘플들로부터 생성되는데, 1가지는 아미노산 112-115를 위한 코돈의 결실을 갖는 것이고, 1가지는 이들 코돈의 결실을 갖지 않는 것이다. c-mpl 리간드 PCR 생성물(약 480 bp)은 포유동물의 발현 벡터 pMON3934로 전달하기 위한 NcoI 및 HindIII 제한효소에 의해 분해된다. pMON3934는 NcoI 및 HindIII(약 3800 bp)에 의해 분해되고, PCR 생성물을 수용할 것이다.

이 클로닝의 결과로서, c-mpl 리간드 아미노산 1-153(SEQ ID NO:546)을 코딩하는 플라스미드 pMON32132(SEQ ID NO:84)를 얻었다. 이 클로닝의 결과로서, c-mpl 리간드 아미노산 1-153(SEQ ID NO:548)을 코딩하는 플라스미드 pMON32134(SEQ ID NO:86)를 얻었다. 또한, 이 클로닝의 결과로서, 코돈 112-115(112-115)(SEQ ID NO:547)의 결실을 갖는 c-mpl 리간드 아미노산 1-153을 코딩하는 플라스미드 pMON32133(SEQ ID NO:85)도 얻었다.

실시예 4

제 2 c-mpl 리간드 유전자 내의 112-115 결실을 갖는 PCR 다이머 주형 5L의 생성

EcoRI/AflIII 5L 합성 올리고뉴클레오티드 링커 5L-5'(SEQ ID NO:322) 및 5L-3'(SEQ ID NO:323)와 함께 pMON32133(아미노산 112-115의 결실을 함유하는)으로부터의 1Kbp NcoI/BstXI 단편에 pMON26458의 3.7Kbp BstXI/EcoRI 단편을 라이게이션함으로써 c-mpl 리간드의 신규 형태를 생성하기 위한 PCR 주형을 구성한다.

링커의 EcoRI 말단은 pMON26458의 EcoRI 말단에 라이게이션될 것이다. 링커의 AflIII 말단은 pMON32133의 NcoI 부위에 라이게이션될 것이고, 어느 제한부위도 라이게이션 시에 유지되지 않을 것이다. pMON26458 및 pMON32133의 BstXI 부위도 역시 라이게이션될 것이다. 플라스미드 pMON28548은 클로닝의 결과이고, 아미노산 112-115(SEQ ID NO:468)의 결실을 함유하는 아미노산 1-153 c-mpl 리간드에 GluPheGlyGlyAsnMetAla (SEQ ID NO:783) 링커에 의해 융합되는 아미노산 1-153 c-mpl 리간드를 암호화하는 (SEQ ID NO:3)의 DNA 서열을 함유한다.

실시예 5

PCR 다이머 주형 4L의 생성

EcoRI/AflIII 4L 합성 올리고뉴클레오티드 링커 4L-5'(SEQ ID NO:320) 및 4L-3'(SEQ ID NO:321)와 함께 pMON32132로부터의 1Kbp NcoI/BstXI 단편에 pMON26458의 3.7Kbp BstXI/EcoRI 단편을 라이게이션함으로써 c-mpl 리간드의 신규 형태를 생성하기 위한 PCR 주형을 구성한다.

링커의 EcoRI 말단은 pMON26458의 EcoRI 말단에 라이게이션될 것이다. 링커의 AflIII 말단은 pMON32132의 NcoI 부위에 라이게이션될 것이고, 어느 제한부위도 라이게이션 시에 유지되지 않을 것이다. pMON26458 및 pMON32132의 BstXI 부위도 역시 라이게이션될 것이다. 플라스미드 pMON28500은 클로닝의 결과이고, 아미노산 1-153 c-mpl 리간드(SEQ ID NO:469)에 GluPheGlyAsnMetAla (SEQ ID NO:223) 링커(4L)에 의해 융합되는 아미노산 1-153 c-mpl 리간드를 암호화하는 (SEQ ID NO:4)의 DNA 서열을 함유한다.

실시예 6

PCR 다이머 주형 5L의 생성

EcoRI/AflIII 5L 합성 올리고뉴클레오티드 링커 5L-5'(SEQ ID NO:322) 및 5L-3'(SEQ ID NO:323)와 함께 pMON32132로부터의 1Kbp NcoI/BstXI 단편에 pMON26458의 3.7Kbp BstXI/EcoRI 단편을 라이게이션함으로써 c-mpl 리간드의 신규 형태를 생성하기 위한 PCR 주형을 구성한다.

링커의 EcoRI 말단은 pMON26458의 EcoRI 말단에 라이게이션될 것이다. 링커의 AflIII 말단은 pMON32132의 NcoI 부위에 라이게이션될 것이고, 어느 제한부위도 라이게이션 시에 유지되지 않을 것이다. pMON26458 및 pMON32132의 BstXI 부위도 역시 라이게이션될 것이다. 플라스미드 pMON28501은 클로닝의 결과이고, 아미노산 1-153 c-mpl 리간드(SEQ ID NO:470)에 GluPheGlyGlyAsnMet (SEQ ID NO:783) 링커(5L)에 의해 융합되는 아미노산 1-153 c-mpl 리간드를 암호화하는 (SEQ ID NO:4)의 DNA 서열을 함유한다.

실시예 7

PCR 다이머 주형 8L의 생성

EcoRI/AflIII 8L 합성 올리고뉴클레오티드 링커 8L-5'(SEQ ID NO:324) 및 8L-3'(SEQ ID NO:325)와 함께 pMON32134로부터의 1Kbp NcoI/BstXI 단편에 pMON26458의 3.7Kbp BstXI/EcoRI 단편을 라이게이션함으로써 c-mpl 리간드의 신규 형태를 생성하기 위한 PCR 주형을 구성한다.

링커의 EcoRI 말단은 pMON26458의 EcoRI 말단에 라이게이션될 것이다. 링커의 AflIII 말단은 pMON32134의 NcoI 부위에 라이게이션될 것이고, 어느 제한부위도 라이게이션 시에 유지되지 않을 것이다. pMON26458 및 pMON32134의 BstXI 부위도 역시 라이게이션될 것이다. 플라스미드 pMON28502는 클로닝의 결과이고, 아미노산 1-153 c-mpl 리간드(SEQ ID NO:471)에 GluPheGlyGlyAsnGlyGlyAsnMetAla (SEQ ID NO:224) 링커(8L)에 의해 융합되는 아미노산 1-153 c-mpl 리간드를 암호화하는 (SEQ ID NO:6)의 DNA 서열을 함유한다.

실시예 8-44

새로운 N-말단 및 C-말단을 갖는 신규 c-mpl 리간드 유전자의 생성

A. 신규 c-mpl 리간드 수용체 아고니스트를 암호화하는 유전자의 PCR 생성.

방법 III(Horlick et al., Prot. Eng. 5:427-433, 1992)을 사용하여 신규 c-mpl 리간드 수용체 아고니스트를 암호화하는 유전자를 생성하였다. 다이머 주형, pMON 28500, 28501, 28502 또는 28548 그리고 아래의 합성 프라이머 세트들 중 하나의 세트를 사용하여 PCR 반응을 수행하였다(첫번째 숫자는 원래 서열 내의 제 1 아미노산의 위치를 나타낸다. 예를 들면, 31-5' 및 31-3'은 원래 서열의 잔기 31에 해당하는 코돈에서 시작되는 서열에 대해 각각 5' 및 3' 올리고 프라이머를 나타낸다.).

31-5'(SEQ ID NO:326) 및 31-3'(SEQ ID NO:327), 35-5'(SEQ ID NO:328) 및 35-3'(SEQ ID NO:329), 39-5'(SEQ ID NO:330) 및 39-3'(SEQ ID NO:331), 43-5'(SEQ ID NO:332) 및 43-3'(SEQ ID NO:333), 45-5'(SEQ ID NO:334) 및 45-3'(SEQ ID NO:335), 49-5'(SEQ ID NO:336) 및 49-3'(SEQ ID NO:337), 82-5'(SEQ ID NO:338) 및 82-3'(SEQ ID NO:339), 109-5'(SEQ ID NO:340) 및 109-3'(SEQ ID NO:341), 115-5'(SEQ ID NO:342) 및 115-3'(SEQ ID NO:343), 120-5'(SEQ ID NO:344) 및 120-3'(SEQ ID NO:345), 123-5'(SEQ ID NO:346) 및 123-3'(SEQ ID NO:347), 126-5'(SEQ ID NO:348) 및 126-3'(SEQ ID NO:349).

PCR 반응에서 사용된 주형 및 올리고뉴클레오티드 세트는 표 4에 나타나 있다. 생성된 생성물은 약 480 bp이었고, Magic PCR Clean up 키트(Promega)에 의해 정제되었다.

B. 신규 c-mpl 수용체 아고니스트 유전자 생성물의 키메라의 생성을 위한 포유동물의 발현 벡터로의 서브클로닝.

c-mpl 수용체 아고니스트 유전자 PCR 생성물을 포유동물의 발현 벡터로의 전달을 위한 NcoI 및 HindIII 또는 AflIII 및 HindIII 제한효소(약 470 bp)에 의해 분해하였다. 발현 벡터 pMON30304를 NcoI 및 HindIII(약 4200 bp)에 의해 분해하였고, PCR 생성물을 NcoI-HindIII 또는 AflIII-HindIII 단편으로서 수용한다. PCR 생성물의 제한 분해물 및 결과되는 플라스미드는 표 4에 나타나 있다.

실시예 #	PCR 주형	PCR 생성물 프라이머 세트	PCR 생성물제한 분해	링커	결과되는플라스미드 pMON	c-mpl리간드내의절단점
실시예 8	pMON28501	31	NcoI/HindIII	5L	28505	30-31
실시예 9	pMON28501	35	AflIII/HindIII	5L	28506	34-35
실시예 10	pMON28501	39	NcoI/HindIII	5L	28507	38-39
실시예 11	pMON28501	43	NcoI/HindIII	5L	28508	42-43
실시예 12	pMON28501	45	NcoI/HindIII	5L	28509	44-45
실시예 13	pMON28501	49	NcoI/HindIII	5L	28510	48-49
실시예 14	pMON28501	82	NcoI/HindIII	5L	28511	81-82
실시예 15	pMON28501	109	NcoI/HindIII	5L	28512	108-109
실시예 16	pMON28501	116	NcoI/HindIII	5L	28513	115-116
실시예 17	pMON28501	120	NcoI/HindIII	5L	28514	119-120
실시예 18	pMON28501	123	NcoI/HindIII	5L	28515	122-123
실시예 19	pMON28501	126	NcoI/HindIII	5L	28516	125-126
실시예 20	pMON28500	31	NcoI/HindIII	4L	28519	30-31
실시예 21	pMON28500	35	AflIII/HindIII	4L	28520	34-35
실시예 22	pMON28500	39	NcoI/HindIII	4L	28521	38-39
실시예 23	pMON28500	43	NcoI/HindIII	4L	28522	42-43
실시예 24	pMON28500	45	NcoI/HindIII	4L	28523	44-45
실시예 25	pMON28500	49	NcoI/HindIII	4L	28524	48-49
실시예 26	pMON28500	82	NcoI/HindIII	4L	28525	81-82
실시예 27	pMON28500	109	NcoI/HindIII	4L	28526	108-109
실시예 28	pMON28500	116	NcoI/HindIII	4L	28527	115-116
실시예 29	pMON28500	120	NcoI/HindIII	4L	28528	119-120
실시예 30	pMON28500	123	NcoI/HindIII	4L	28529	122-123
실시예 31	pMON28500	126	NcoI/HindIII	4L	28530	125-126
실시예 32	pMON28502	31	NcoI/HindIII	8L	28533	30-31
실시예 33	pMON28502	35	AflIII/HindIII	8L	28534	34-35
실시예 34	pMON28502	39	NcoI/HindIII	8L	28535	38-39
실시예 35	pMON28502	43	NcoI/HindIII	8L	28536	42-43
실시예 36	pMON28502	45	NcoI/HindIII	8L	28537	44-45
실시예 37	pMON28502	49	NcoI/HindIII	8L	28538	48-49
실시예 38	pMON28502	82	NcoI/HindIII	8L	28539	81-82
실시예 39	pMON28502	109	NcoI/HindIII	8L	28540	108-109
실시예 40	pMON28502	116	NcoI/HindIII	8L	28541	115-116
실시예 41	pMON28502	120	NcoI/HindIII	8L	28542	119-120
실시예 42	pMON28502	123	NcoI/HindIII	8L	28543	122-123
실시예 43	pMON28502	126	NcoI/HindIII	8L	28544	125-126
실시예 44	pMON28548	123	NcoI/HindIII	5L	28545	122-123

실시예 45

pMON15960의 구성

새로운 N-말단 및 C-말단을 갖는 G-CSF Ser¹⁷을 암호화하는 DNA 서열을 함유하는 플라스미드를 구성하기 위해 사용되는 중간 플라스미드 pMON15960의 구성. 플라스미드 pACYC177(Chang, A.C.Y. 및 Cohen, S.N. J. Bacteriol. 134:1141-1156, 1978) DNA를 제한효소 HindIII 및 BamHI에 의해 분해하였고, 이로 인해 3092 염기쌍 HindIII, BamHI 단편을 얻었다. 플라스미드, pMON13037(WO 95/21254), DNA를 BglII 및 FspI에 의해 분해하였고, 이로 인해 616 염기쌍 BglII, FspI 단편을 얻었다. 플라스미드, pMON13037, DNA의 제 2 샘플을 NcoI 및 HindIII에 의해 분해하였고, 이로 인해 556 염기쌍 NcoI, HindIII 단편을 얻었다. 합성 DNA 올리고뉴클레오티드 1GGGSfor(SEQ ID NO:380) 및 1GGGSrev(SEQ ID NO:381)을 상호 어닐링한 후, AflIII 및 FspI에 의해 분해하고, 이로 인해 21 염기쌍 AflIII, FspI 단편을 얻었다. 제한단편들을 리가게이션하고, 리가게이션 반응혼합물을 E. coli K-12 균주 JM101로 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 제한분석에 의해 분석하여 정확한 삽입을 확인하였다.

실시예 46

pMON15981의 구성

다기능 조혈 수용체 아고니스트를 암호화하는 DNA 서열을 함유하는 플라스미드 pMON15981의 구성. 플라스미드, pMON15960, DNA를 제한효소 SmaI에 의해 분해하고, 합성 DNA 올리고뉴클레오티드 38 스톱(SEQ ID NO:369) 및 39 스타트(SEQ ID NO:368)를 프라이머로서 사용하는 PCR 반응에서 주형으로서 사용하고, 이로 인해 576 염기쌍의 DNA 단편의 증폭을 얻었다. 증폭된 단편을 제한효소 HindIII 및 NcoI에 의해 분해하였고, 이로 인해 558 염기쌍의 HindIII, NcoI 단편을 얻었다. 플라스미드, pMON13181, DNA를 HindIII 및 AflIII에 의해 분해하였고, 이로 인해 4068 염기쌍의 HindIII, AflIII 단편을 얻었다. 제한단편을 리가게이션하였고, 리가게이션 반응혼합물을 E. coli K-12 균주 JM101로 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 제한분석에 의해 분석하고, 서열화하여 정확한 삽입을 확인하였다. 플라스미드, pMON15981은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:78)의 DNA 서열을 함유한다:

MetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAla

ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsn

LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer

GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPro

SerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr

PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaTyrLysLeuCysHisProGluGluLeuValLeuLeu

GlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGln

LeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGln

AlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspVal

AlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeu

GlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGly

ValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHis

LeuAlaGlnProGlyGlyGlySerAspMetAlaThrProLeuGlyProAlaSerSerLeu

ProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAla

AlaLeuGlnGluLysLeuCysAlaThr (SEQ ID NO:500)

실시예 47

pMON15982의 구성

다기능 조혈 수용체 아고니스트를 암호화하는 DNA 서열을 함유하는 플라스미드 pMON15982의 구성. 플라스미드, pMON15960, DNA를 제한효소 SmaI에 의해 분해하고, 합성 DNA 올리고뉴클레오티드 96 스톱(SEQ ID NO:371) 및 97 스타트(SEQ ID NO:370)를 프라이머로서 사용하는 PCR 반응에서 주형으로서 사용하고, 이로 인해 576 염기쌍의 DNA 단편의 증폭을 얻었다. 증폭된 단편을 제한효소 HindIII 및 NcoI에 의해 분해하고, 이로 인해 558 염기쌍의 HindIII, NcoI 단편을 얻었다. 플라스미드, pMON13181, DNA를 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍의 HindIII, AflIII 단편을 얻었다. 제한단편을 라이게이션하고, 라이게이션 반응혼합물을 E. coli K-12 균주 JM101로 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 제한분석에 의해 분석하고, 서열화하여 정확한 삽입을 확인하였다. 플라스미드, pMON15982은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:79)의 DNA 서열을 함유한다:

MetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAla

ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsn

LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer

GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPro

SerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr

PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaProGluLeuGlyProThrLeuAspThrLeuGlnLeu

AspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaPro

AlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAla

GlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeu

ArgHisLeuAlaGlnProGlyGlyGlySerAspMetAlaThrProLeuGlyProAlaSer

SerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAsp

GlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeu

ValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGln

AlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGly

LeuLeuGlnAlaLeuGluGlyIleSer (SEQ ID NO:501)

실시예 48

pMON15965의 구성

다기능 조혈 수용체 아고니스트를 암호화하는 DNA 서열을 함유하는 플라스미드 pMON15965의 구성. 플라스미드, pMON15960, DNA를 제한효소 SmaI에 의해 분해하고, 합성 DNA 올리고뉴클레오티드 142 스톱(SEQ ID NO:377) 및 141 스타트(SEQ ID NO:376)를 프라이머로서 사용하는 PCR 반응에서 주형으로서 사용하고, 이로 인해 576 염기쌍의 DNA 단편의 증폭을 얻었다. 증폭된 단편을 제한효소 HindIII 및 NcoI에 의해 분해하고, 이로 인해 558 염기쌍의 HindIII, NcoI 단편을 얻었다. 플라스미드, pMON13181, DNA를 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍의 HindIII, AflIII 단편을 얻었다. 제한단편을 라이게이션하고, 라이게이션 반응혼합물을 E. coli K-12 균주 JM101로 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 제한분석에 의해 분석하고, 서열화하여 정확한 삽입을 확인하였다. 플라스미드, pMON15965는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:80)의 DNA 서열을 함유한다:

MetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAla

ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsn

LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer

GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPro

SerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr

PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuVal

AlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGln

ProGlyGlyGlySerAspMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSer

PheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGln

GluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHis

SerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAla

GlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeu

GluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAsp

PheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnPro

ThrGlnGlyAlaMetProAlaPheAla (SEQ ID NO:502)

실시예 49

pMON15966의 구성

다기능 조혈 수용체 아고니스트를 암호화하는 DNA 서열을 함유하는 플라스미드 pMON15966의 구성. 플라스미드, pMON15960, DNA를 제한효소 SmaI에 의해 분해하고, 합성 DNA 올리고뉴클레오티드 126 스톱(SEQ ID NO:372) 및 125 스타트(SEQ ID NO:373)를 프라이머로서 사용하는 PCR 반응에서 주형으로서 사용하고, 이로 인해 576 염기쌍의 DNA 단편의 증폭을 얻었다. 증폭된 단편을 제한효소 HindIII 및 NcoI에 의해 분해하고, 이로 인해 558 염기쌍의 HindIII, NcoI 단편을 얻었다. 플라스미드, pMON13181, DNA를 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍의 HindIII, AflIII 단편을 얻었다. 제한단편을 라이게이션하고, 라이게이션 반응혼합물을 E. coli K-12 균주 JM101로 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 제한분석에 의해 분석하고, 서열화하여 정확한 삽입을 확인하였다. 플라스미드, pMON15966은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:81)의 DNA 서열을 함유한다:

MetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAla

ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsn

LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer

GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPro

SerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr

PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaMetAlaProAlaLeuGlnProThrGlnGlyAlaMet

ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeu

GlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProGlyGlyGly

SerAspMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLys

SerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCys

AlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIle

ProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSer

GlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSer

ProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThr

IleTrpGlnGlnMetGluGluLeuGly (SEQ ID NO:503)

실시예 50

pMON15967의 구성

다기능 조혈 수용체 아고니스트를 암호화하는 DNA 서열을 함유하는 플라스미드 pMON15967의 구성. 플라스미드, pMON15960, DNA를 제한효소 SmaI에 의해 분해하고, 합성 DNA 올리고뉴클레오티드 132 스톱(SEQ ID NO:375) 및 133 스타트(SEQ ID NO:374)를 프라이머로서 사용하는 PCR 반응에서 주형으로서 사용하고, 이로 인해 576 염기쌍의 DNA 단편의 증폭을 얻었다. 증폭된 단편을 제한효소 HindIII 및 NcoI에 의해 분해하고, 이로 인해 558 염기쌍의 HindIII, NcoI 단편을 얻었다. 플라스미드, pMON13181, DNA를 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍의 HindIII, AflIII 단편을 얻었다. 제한단편을 라이게이션하고, 라이게이션 반응혼합물을 E. coli K-12 균주 JM101로 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 제한분석에 의해 분석하고, 서열화하여 정확한 삽입을 확인하였다. 플라스미드, pMON15967은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:82)의 DNA 서열을 함유한다:

MetAlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAla

ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsn

LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer

GlyIleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPro

SerArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr

PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly

SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsnMetAlaThrGlnGlyAlaMetProAlaPheAlaSerAlaPhe

GlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSer

TyrArgValLeuArgHisLeuAlaGlnProGlyGlyGlySerAspMetAlaThrProLeu

GlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLys

IleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHis

ProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSer

CysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPhe

LeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeu

AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGlu

LeuGlyMetAlaProAlaLeuGlnPro SEQ ID NO:504

실시예 51

다기능 조혈 수용체 아고니스트를 암호화하는 DNA 서열을 함유하는 플라스미드를 구성하기 위해 사용되는 중간 플라스미드, pMON13180의 구성.

플라스미드, pMON13046(WO 95/21254), DNA를 제한 엔도뉴클레아제 XmaI 및 SnaBI에 의해 분해하고, 이로 인해 4018 염기쌍 벡터 단편을 얻었다. 25 염기쌍 XmaI-SnaBI 삽입 단편이 유지되지 않는 Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 4018 염기쌍 XmaI-SnaBI 단편을 정제하였다. 인자 Xa 분열 부위를 암호화하는 서열을 제거하도록 합성 올리고뉴클레오티드의 상보쌍인 glyxa1(SEQ ID NO:378) 및 glyxa2(SEQ ID NO:379)를 설계하였다. 적절히 조립되었을 때, 이들 올리고뉴클레오티드는 또한 XmaI 및 SnaBI 말단이 된다. 70℃에서 10분 동안 가열하고 서서히 냉각되도록 함으로써 프라이머 glyxa1 및 glyxa2를 어닐링 완충액(20mM Tris-HCl pH 7.5, 10mM MgCl₂, 50mM NaCl) 중에서 어닐링하였다. T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 pMON13046으로부터의 4018 염기쌍 XmaI-SnaBI 단편을 조립된 올리고뉴클레오티드와 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 형질전환체로부터 분리하고 PCR에 근거한 분석을 사용하여 분석하였다. 선택된 형질전환체로부터의 플라스미드 DNA를 서열화하여 올리고뉴클레오티드의 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13180(SEQ ID NO:88)으로 표시하였다.

실시예 52

다기능 조혈 수용체 아고니스트를 암호화하는 DNA 서열을 함유하는 플라스미드를 구성하기 위해 사용되는 중간 플라스미드, pMON13181의 구성.

플라스미드, pMON13047(WO 95/21254), DNA를 제한 엔도뉴클레아제 XmaI 및 SnaBI에 의해 분해하고, 이로 인해 4063 염기쌍 벡터 단편을 얻었다. 25 염기쌍 XmaI-SnaBI 삽입 단편이 유지되지 않는 Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 4063 염기쌍 XmaI-SnaBI 단편을 정제하였다. 인자 Xa 분열 부위를 암호화하는 서열을 제거하도록 합성 올리고뉴클레오티드의 상보쌍인 glyxa1(SEQ ID NO:378) 및 glyxa2(SEQ ID NO:379)를 설계하였다. 적절히 조립되었을 때, 이들 올리고뉴클레오티드는 또한 XmaI 및 SnaBI 말단이 된다. 70℃에서 10분 동안 가열하고 서서히 냉각되도록 함으로써 glyxa1 및 glyxa2를 어닐링 완충액 중에서 어닐링하였다. T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 pMON13047로부터의 4063 염기쌍 XmaI-SnaBI 단편을 조립된 올리고뉴클레오티드와 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 형질전환체로부터 분리하고 PCR에 근거한 분석을 사용하여 분석하였다. 선택된 형질전환체로부터의 플라스미드 DNA를 서열화하여 올리고뉴클레오티드의 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13181(SEQ ID NO:87)로 표시하였다.

실시예 53

pMON13182의 구성

재료 및 방법란에 기술된 Method I을 사용하여 pMON13182 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 39 스타트(SEQ ID NO:368) 및 L-11 스타트(SEQ ID NO:364)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 38 스톱(SEQ ID NO:369) 및 L-11 스톱(SEQ ID NO:365)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 만들고, 프라이머 39 스타트 및 38 스톱을 사용하여 어닐링된 단편 스타트 및 스톱으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해하고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 중간 플라스미드 pMON13180을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4023 염기쌍 벡터 단편을 얻었고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13182로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13182로 형질전환하였다.

플라스미드 pMON13182는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:17)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Tyr Lys Leu Cys

His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro

Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala

Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly

Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr

Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile

Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly

Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val

Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys

Ala Thr (SEQ ID NO:472)

실시예 54

pMON13183의 구성

재료 및 방법란에 기술된 Method I을 사용하여 pMON13183 내의 새로운 N-말단/C-말단 유전자를 만들었다. "단편 스타트"를 만들고, 프라이머 세트, 39 스타트(SEQ ID NO:368) 및 L-11 스타트(SEQ ID NO:364)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 38 스톱(SEQ ID NO:369) 및 L-11 스톱(SEQ ID NO:365)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 만들고, 39 스타트 및 38 스톱을 사용하여 어닐링된 단편 스타트 및 스톱으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해하고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 중간 플라스미드 pMON13181을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍 벡터 단편을 얻었고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13183으로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13183으로 형질전환하였다.

플라스미드 pMON13183은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:18)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Tyr Lys Leu Cys

His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro

Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala

Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly

Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr

Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile

Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly

Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val

Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys

Ala Thr (SEQ ID NO:473)

실시예 55

pMON13184의 구성

재료 및 방법란에 기술된 Method I을 사용하여 pMON13184 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 97 스타트(SEQ ID NO:370) 및 L-11 스타트(SEQ ID NO:364)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 96 스톱(SEQ ID NO:371) 및 L-11 스톱(SEQ ID NO:365)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 만들고, 97 스타트 및 96 스톱을 사용하여 어닐링된 단편 스타트 및 스톱으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해하고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 중간 플라스미드 pMON13180을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4023 염기쌍 벡터 단편을 얻었고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13184로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13184로 형질전환하였다.

플라스미드 pMON13184는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:19)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr

Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser

Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu

Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu

Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys

Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His

Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly

Ile Ser (SEQ ID NO:474)

실시예 56

pMON13185의 구성

재료 및 방법란에 기술된 Method I을 사용하여 pMON13185 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 97 스타트(SEQ ID NO:370) 및 L-11 스타트(SEQ ID NO:364)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 96 스톱(SEQ ID NO:371) 및 L-11 스톱(SEQ ID NO:365)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 만들고, 97 스타트 및 96 스톱을 사용하여 어닐링된 단편 스타트 및 스톱으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해하고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 중간 플라스미드 pMON13181을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍 벡터 단편을 얻었고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13185로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13185로 형질전환하였다.

플라스미드 pMON13185는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:20)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr

Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser

Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu

Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu

Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys

Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His

Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly

Ile Ser (SEQ ID NO:475)

실시예 57

pMON13186의 구성

재료 및 방법란에 기술된 Method I을 사용하여 pMON13186 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 126 스타트(SEQ ID NO:372) 및 L-11 스타트(SEQ ID NO:364)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 125 스톱(SEQ ID NO:373) 및 L-11 스톱(SEQ ID NO:365)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 만들고, 126 스타트 및 125 스톱을 사용하여 어닐링된 단편 스타트 및 스톱으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해하고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 중간 플라스미드 pMON13180을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4023 염기쌍 벡터 단편을 얻었고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13186으로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13186으로 형질전환하였다.

플라스미드 pMON13186은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:21)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Met Ala Pro Ala

Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe

Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro

Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu

Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu

Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val

Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser

Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu

His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu

Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu

Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu

Leu Gly (SEQ ID NO:476)

실시예 58

pMON13187의 구성

재료 및 방법란에 기술된 Method I을 사용하여 pMON13187 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 126 스타트(SEQ ID NO:372) 및 L-11 스타트(SEQ ID NO:364)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 125 스톱(SEQ ID NO:373) 및 L-11 스톱(SEQ ID NO:365)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 만들고, 126 스타트 및 125 스톱을 사용하여 어닐링된 단편 스타트 및 스톱으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해하고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 중간 플라스미드 pMON13181을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍 벡터 단편을 얻었고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13187로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13187로 형질전환하였다.

플라스미드 pMON13187은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:22)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Met Ala Pro Ala

Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe

Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro

Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu

Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu

Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val

Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser

Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu

His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu

Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu

Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu

Leu Gly (SEQ ID NO:477)

실시예 59

pMON13188의 구성

재료 및 방법란에 기술된 Method I을 사용하여 pMON13188 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 133 스타트(SEQ ID NO:374) 및 L-11 스타트(SEQ ID NO:364)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 132 스톱(SEQ ID NO:375) 및 L-11 스톱(SEQ ID NO:365)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 만들고, 133 스타트 및 132 스톱을 사용하여 어닐링된 단편 스타트 및 스톱으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해하고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 중간 플라스미드 pMON13180을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4023 염기쌍 벡터 단편을 얻었고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13188로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13188로 형질전환하였다.

플라스미드 pMON13188은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:23)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Thr Gln Gly Ala

Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val

Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg

Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser

Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln

Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys

Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly

Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln

Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr

Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr

Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gln Pro (SEQ ID NO:478)

실시예 60

pMON13189의 구성

재료 및 방법란에 기술된 Method I을 사용하여 pMON13189 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 133 스타트(SEQ ID NO:374) 및 L-11 스타트(SEQ ID NO:364)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 132 스톱(SEQ ID NO:375) 및 L-11 스톱(SEQ ID NO:365)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 만들고, 133 스타트 및 132 스톱을 사용하여 어닐링된 단편 스타트 및 스톱으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해하고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 중간 플라스미드 pMON13181을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍 벡터 단편을 얻었고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13189로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13189로 형질전환하였다.

플라스미드 pMON13189는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:24)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Gln Gly Ala

Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val

Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg

Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser

Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln

Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys

Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly

Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln

Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr

Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr

Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gln Pro (SEQ ID NO:479)

실시예 61

pMON13190의 구성

재료 및 방법란에 기술된 Method I을 사용하여 pMON13190 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 142 스타트(SEQ ID NO:376) 및 L-11 스타트(SEQ ID NO:364)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 141 스톱(SEQ ID NO:377) 및 L-11 스톱(SEQ ID NO:365)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 만들고, 142 스타트 및 141 스톱을 사용하여 어닐링된 단편 스타트 및 스톱으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해하고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 중간 플라스미드 pMON13180을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4023 염기쌍 벡터 단편을 얻었고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13190으로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13190으로 형질전환하였다.

플라스미드 pMON13190은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:25)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser

Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu

Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu

Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys

Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His

Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly

Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp

Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu

Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala

Phe Ala (SEQ ID NO:480)

실시예 62

pMON13191의 구성

재료 및 방법란에 기술된 Method I을 사용하여 pMON13191 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 142 스타트(SEQ ID NO:376) 및 L-11 스타트(SEQ ID NO:364)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 141 스톱(SEQ ID NO:377) 및 L-11 스톱(SEQ ID NO:365)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 만들고, 142 스타트 및 141 스톱을 사용하여 어닐링된 단편 스타트 및 스톱으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해하고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 중간 플라스미드 pMON13181을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍 벡터 단편을 얻었고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13191로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13191로 형질전환하였다.

플라스미드 pMON13191은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:26)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser

Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu

Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu

Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys

Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His

Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly

Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp

Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu

Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala

Phe Ala (SEQ ID NO:481)

실시예 63

pMON13192의 구성

재료 및 방법란에 기술된 Method II를 사용하여 pMON13192 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 39 스타트(SEQ ID NO:368) 및 P-bl 스타트(SEQ ID NO:366)를 사용하여 pMON13037 내의 G-CSF 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 38 스톱(SEQ ID NO:369) 및 P-bl 스톱(SEQ ID NO:367)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스타트를 제한 엔도뉴클레아제 NcoI에 의해 분해하고, 단편 스톱을 제한 엔도뉴클레아제 HindIII에 의해 분해하였다. 정제 후에, 분해된 단편 스타트 및 스톱을 pMON3934의 대략 3800 염기쌍 NcoI-HindIII 벡터 단편과 조합하고, 이 단편에 라이게이션하였다.

상기 중간 플라스미드는 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 함유하였고, 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해되었다. 분해된 DNA를 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 중간 플라스미드 pMON13180를 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4023 염기쌍 벡터 단편을 얻고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 새로운 유전자의 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13192로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13192로 형질전환하였다.

플라스미드 pMON13192는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:27)의 DNA 서열을 함유한다:

13192.Pept

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Tyr Lys Leu Cys

His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro

Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala

Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly

Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr

Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile

Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr Pro Leu

Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu

Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu

Lys Leu Cys Ala Thr (SEQ ID NO:482)

실시예 64

pMON13193의 구성

재료 및 방법란에 기술된 Method II를 사용하여 pMON13193 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 39 스타트(SEQ ID NO:368) 및 P-bl 스타트(SEQ ID NO:366)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 38 스톱(SEQ ID NO:369) 및 P-bl 스톱(SEQ ID NO:367)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스타트를 제한 엔도뉴클레아제 NcoI에 의해 분해하고, 단편 스톱을 제한 엔도뉴클레아제 HindIII에 의해 분해하였다. 정제 후에, 분해된 단편 스타트 및 스톱을 pMON3934의 대략 3800 염기쌍 NcoI-HindIII 벡터 단편과 조합하고, 이 단편에 라이게이션하였다.

상기 중간 플라스미드는 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 함유하였고, 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해되었다. 분해된 DNA를 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 중간 플라스미드 pMON13181을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍 벡터 단편을 얻고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 새로운 유전자의 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13193으로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13193으로 형질전환하였다.

플라스미드 pMON13193은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:28)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Tyr Lys Leu Cys

His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro

Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala

Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly

Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr

Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile

Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr Pro Leu

Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu

Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu

Lys Leu Cys Ala Thr (SEQ ID NO:483)

실시예 65

pMON25190의 구성

재료 및 방법란에 기술된 Method II를 사용하여 pMON25190 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 97 스타트(SEQ ID NO:370) 및 P-bl 스타트(SEQ ID NO:366)를 사용하여 pMON13037 내의 G-CSF 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 96 스톱(SEQ ID NO:371) 및 P-bl 스톱(SEQ ID NO:367)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스타트를 제한 엔도뉴클레아제 NcoI에 의해 분해하고, 단편 스톱을 제한 엔도뉴클레아제 HindIII에 의해 분해하였다. 정제 후에, 분해된 단편 스타트 및 스톱을 pMON3934의 대략 3800 염기쌍 NcoI-HindIII 벡터 단편과 조합하고, 이 단편에 라이게이션하였다.

상기 중간 플라스미드는 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 함유하였고, 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해되었다. 분해된 DNA를 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 중간 플라스미드 pMON13180을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4023 염기쌍 벡터 단편을 얻고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 새로운 유전자의 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON25190으로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON25190으로 형질전환하였다.

플라스미드 pMON25190은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:29)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr

Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr

Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys

Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu

Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu

Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu

Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser

Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala

Leu Glu Gly Ile Ser (SEQ ID NO:484)

실시예 66

pMON25191의 구성

재료 및 방법란에 기술된 Method II를 사용하여 pMON25191 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 97 스타트(SEQ ID NO:370) 및 P-bl 스타트(SEQ ID NO:366)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 96 스톱(SEQ ID NO:371) 및 P-bl 스톱(SEQ ID NO:367)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스타트를 제한 엔도뉴클레아제 NcoI에 의해 분해하고, 단편 스톱을 제한 엔도뉴클레아제 HindIII에 의해 분해하였다. 정제 후에, 분해된 단편 스타트 및 스톱을 pMON3934의 대략 3800 염기쌍 NcoI-HindIII 벡터 단편과 조합하고, 이 단편에 라이게이션하였다.

상기 중간 플라스미드는 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 함유하였고, 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해되었다. 분해된 DNA를 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 중간 플라스미드 pMON13181을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍 벡터 단편을 얻고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 새로운 유전자의 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON25191로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON25191로 형질전환하였다.

플라스미드 pMON25191은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:30)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr

Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr

Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys

Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu

Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu

Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu

Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser

Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala

Leu Glu Gly Ile Ser (SEQ ID NO:485)

실시예 67

pMON13194의 구성

재료 및 방법란에 기술된 Method II를 사용하여 pMON13194 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 126 스타트(SEQ ID NO:372) 및 P-bl 스타트(SEQ ID NO:366)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 125 스톱(SEQ ID NO:371) 및 P-bl 스톱(SEQ ID NO:367)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스타트를 제한 엔도뉴클레아제 NcoI에 의해 분해하고, 단편 스톱을 제한 엔도뉴클레아제 HindIII에 의해 분해하였다. 정제 후에, 분해된 단편 스타트 및 스톱을 pMON3934의 대략 3800 염기쌍 NcoI-HindIII 벡터 단편과 조합하고, 이 단편에 라이게이션하였다.

상기 중간 플라스미드는 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 함유하였고, 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해되었다. 분해된 DNA를 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 중간 플라스미드 pMON13180을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4023 염기쌍 벡터 단편을 얻고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 새로운 유전자의 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13194로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13194로 형질전환하였다.

플라스미드 pMON13194는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:31)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Met Ala Pro Ala

Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe

Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu

Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala

Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu

Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro

Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu

Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln

Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr

Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln

Met Glu Glu Leu Gly (SEQ ID NO:486)

실시예 68

pMON13195의 구성

재료 및 방법란에 기술된 Method II를 사용하여 pMON13195 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 126 스타트(SEQ ID NO:372) 및 P-bl 스타트(SEQ ID NO:366)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 125 스톱(SEQ ID NO:373) 및 P-bl 스톱(SEQ ID NO:367)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스타트를 제한 엔도뉴클레아제 NcoI에 의해 분해하고, 단편 스톱을 제한 엔도뉴클레아제 HindIII에 의해 분해하였다. 정제 후에, 분해된 단편 스타트 및 스톱을 pMON3934의 대략 3800 염기쌍 NcoI-HindIII 벡터 단편과 조합하고, 이 단편에 라이게이션하였다.

상기 중간 플라스미드는 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 함유하였고, 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해되었다. 분해된 DNA를 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 중간 플라스미드 pMON13181을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍 벡터 단편을 얻고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 새로운 유전자의 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13195로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13195로 형질전환하였다.

플라스미드 pMON13195는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:32)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Met Ala Pro Ala

Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe

Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu

Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala

Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu

Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro

Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu

Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln

Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr

Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln

Met Glu Glu Leu Gly (SEQ ID NO:487)

실시예 69

pMON13196의 구성

재료 및 방법란에 기술된 Method II를 사용하여 pMON13196 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 133 스타트(SEQ ID NO:374) 및 P-bl 스타트(SEQ ID NO:366)를 사용하여 pMON13037 내의 G-CSF 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 132 스톱(SEQ ID NO:375) 및 P-bl 스톱(SEQ ID NO:367)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스타트를 제한 엔도뉴클레아제 NcoI에 의해 분해하고, 단편 스톱을 제한 엔도뉴클레아제 HindIII에 의해 분해하였다. 정제 후에, 분해된 단편 스타트 및 스톱을 pMON3934의 대략 3800 염기쌍 NcoI-HindIII 벡터 단편과 조합하고, 이 단편에 라이게이션하였다.

상기 중간 플라스미드는 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 함유하였고, 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해되었다. 분해된 DNA를 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 중간 플라스미드 pMON13180을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4023 염기쌍 벡터 단편을 얻고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 새로운 유전자의 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13196으로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13196으로 형질전환하였다.

플라스미드 pMON13196은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:33)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Thr Gln Gly Ala

Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val

Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg

Val Leu Arg His Leu Ala Gln Pro Thr Pro Leu Gly Pro Ala Ser

Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg

Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala

Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His

Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln

Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu

Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro

Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp

Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala

Pro Ala Leu Gln Pro (SEQ ID NO:488)

실시예 70

pMON13197의 구성

재료 및 방법란에 기술된 Method II를 사용하여 pMON13197 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 133 스타트(SEQ ID NO:374) 및 P-bl 스타트(SEQ ID NO:366)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 132 스톱(SEQ ID NO:375) 및 P-bl 스톱(SEQ ID NO:367)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스타트를 제한 엔도뉴클레아제 NcoI에 의해 분해하고, 단편 스톱을 제한 엔도뉴클레아제 HindIII에 의해 분해하였다. 정제 후에, 분해된 단편 스타트 및 스톱을 pMON3934의 대략 3800 염기쌍 NcoI-HindIII 벡터 단편과 조합하고, 이 단편에 라이게이션하였다.

상기 중간 플라스미드는 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 함유하였고, 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해되었다. 분해된 DNA를 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 중간 플라스미드 pMON13181을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍 벡터 단편을 얻고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 새로운 유전자의 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13197로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13197로 형질전환하였다.

플라스미드 pMON13197은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:34)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Tyr Lys Leu Cys

His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro

Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala

Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly

Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr

Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile

Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr Pro Leu

Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu

Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu

Lys Leu Cys Ala Thr (SEQ ID NO:489)

실시예 71

pMON13198의 구성

재료 및 방법란에 기술된 Method II를 사용하여 pMON13198 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 142 스타트(SEQ ID NO:376) 및 P-bl 스타트(SEQ ID NO:366)를 사용하여 pMON13037 내의 G-CSF 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 141 스톱(SEQ ID NO:377) 및 P-bl 스톱(SEQ ID NO:367)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스타트를 제한 엔도뉴클레아제 NcoI에 의해 분해하고, 단편 스톱을 제한 엔도뉴클레아제 HindIII에 의해 분해하였다. 정제 후에, 분해된 단편 스타트 및 스톱을 pMON3934의 대략 3800 염기쌍 NcoI-HindIII 벡터 단편과 조합하고, 이 단편에 라이게이션하였다.

상기 중간 플라스미드는 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 함유하였고, 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해되었다. 분해된 DNA를 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 중간 플라스미드 pMON13180을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4023 염기쌍 벡터 단편을 얻고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 새로운 유전자의 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13198로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13198로 형질전환하였다.

플라스미드 pMON13198은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:35)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr

Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys

Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu

Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu

Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu

Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser

Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala

Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu

Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met

Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala

Met Pro Ala Phe Ala (SEQ ID NO:490)

실시예 72

pMON13199의 구성

재료 및 방법란에 기술된 Method II를 사용하여 pMON13199 내의 새로운 N-말단/C-말단 유전자를 만들었다. 단편 스타트를 만들고, 프라이머 세트, 142 스타트(SEQ ID NO:376) 및 P-bl 스타트(SEQ ID NO:366)를 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스톱을 만들고, 프라이머 세트, 141 스톱(SEQ ID NO:377) 및 P-bl 스톱(SEQ ID NO:367)을 사용하여 pMON13037 내의 G-CSF Ser¹⁷ 서열로부터 증폭시켰다. 단편 스타트를 제한 엔도뉴클레아제 NcoI에 의해 분해하고, 단편 스톱을 제한 엔도뉴클레아제 HindIII에 의해 분해하였다. 정제 후에, 분해된 단편 스타트 및 스톱을 pMON3934의 대략 3800 염기쌍 NcoI-HindIII 벡터 단편과 조합하고, 이 단편에 라이게이션하였다.

상기 중간 플라스미드는 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 함유하였고, 제한 엔도뉴클레아제 NcoI 및 HindIII에 의해 분해되었다. 분해된 DNA를 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, 전체길이의 새로운 N-말단/C-말단 G-CSF Ser¹⁷ 유전자를 Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 중간 플라스미드 pMON13181을 제한 엔도뉴클레아제 HindIII 및 AflIII에 의해 분해하고, 이로 인해 4068 염기쌍 벡터 단편을 얻고, Magic DNA Clean-up System 키트(Promega, Madison, WI)를 사용하여 정제하였다. 정제된 제한단편을 조합하고, T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 라이게이션하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 새로운 유전자의 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON13199로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON13199로 형질전환하였다.

플라스미드 pMON13199는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:36)의 DNA 서열을 함유한다:

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Ser Ala Phe Gln

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr

Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys

Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu

Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu

Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu

Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser

Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala

Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu

Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met

Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala

Met Pro Ala Phe Ala (SEQ ID NO:491)

실시예 73

탠덤식으로 중복된 플라스미드 주형, Syntan1의 구성

탠덤식으로 중복된 hIL-3 수용체 아고니스트 pMON13416 주형, Synta1을 만들기 위해, T4 DNA 리가제(Boehringer Mannheim)를 사용하는 라이게이션에 의해 3가지의 DNA를 결합하였다. 3가지의 DNA는 다음과 같다: 1) hIL-3 수용체 아고니스트 pMON13416을 함유하고, BstEII 및 SnaBI에 의해 분해된, pMON13046; 2) 원래 단백질의 C-말단 및 N-말단을 연결하는 링커를 암호화하는 서열과 소량의 주위 pMON13416 서열을 함유하고, 적절히 조립될 때 BstEII 및 ClaI 말단이 되는, 합성 올리고뉴클레오티드의 어닐링된 상보쌍, L1syn.for(SEQ ID NO:352) 및 L1syn.rev(SEQ ID NO:353); 및 3) ClaI(DNA는 dam-세포 내에서 성장하였음, DM1(Life Technologies)) 및 SnaBI에 의해 pMON13046으로부터 분해된 hIL-3 수용체 아고니스트 pMON13416의 일부. 분해된 DNA를 0.9TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, Geneclean(Bio101)을 사용하여 분리하였다.

라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체로부터 미니프레프 DNA를 분리하고, PCR에 근거한 분석을 사용하여 형질전환체를 스크리닝하였다. 선택된 형질전환체로부터의 플라스미드 DNA를 서열화하여 정확한 주형을 얻었다. 결과되는 플라스미드는 syntan1로 표시되었고, (SEQ ID NO:7)의 DNA 서열을 함유한다.

실시예 74

탠덤식으로 중복된 주형, syntan3의 구성

탠덤식으로 중복된 hIL-3 수용체 아고니스트 pMON13416 주형, syntan3을 만들기 위해, T4 DNA 리가제(Boehringer Mannheim)를 사용하는 라이게이션에 의해 3가지의 DNA를 결합하였다. 3가지의 DNA는 다음과 같다: 1) hIL-3 수용체 아고니스트 pMON13416을 함유하고, BstEII 및 SnaBI에 의해 분해된, pMON13046; 2) 원래 단백질의 C-말단 및 N-말단을 연결하는 링커를 암호화하는 서열과 소량의 주위 pMON13416 서열을 함유하고, 적절히 조립될 때 BstEII 및 SnaBI 말단이 되는, 합성 올리고뉴클레오티드의 어닐링된 상보쌍, L3syn.for(SEQ ID NO:354) 및 L3syn.rev(SEQ ID NO:355); 및 3) ClaI(DNA는 dam-세포 내에서 성장하였음, DM1(Life Technologies)) 및 SnaBI에 의해 pMON13046으로부터 분해된 hIL-3 수용체 아고니스트 pMON13416의 일부. 분해된 DNA를 0.9TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, Geneclean(Bio101)을 사용하여 분리하였다.

라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체로부터 미니프레프 DNA를 분리하고, PCR에 근거한 분석을 사용하여 형질전환체를 스크리닝하였다. 선택된 형질전환체로부터의 플라스미드 DNA를 서열화하여 정확한 주형을 얻었다. 결과되는 플라스미드는 syntan3로 표시되었고, (SEQ ID NO:8)의 DNA 서열을 함유한다.

실시예 75

pMON31104의 구성

재료 및 방법란에 기술된 Method III를 사용하여 pMON31104 내의 새로운 N-말단/C-말단 유전자를 만들었다. hIL-3 수용체 아고니스트 pMON13416의 전체길이의 새로운 N-말단/C-말단 유전자를 만들고, 프라이머 세트 35 스타트(SEQ ID NO:356) 및 34 rev(SEQ ID NO:357)을 사용하여 중간 플라스미드 Syntan1로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 SnaBI에 의해 분해하였다. 분해된 DNA 단편을 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 정제되고 분해된 DNA 단편을 T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 발현 벡터 pMON13189로 라이게이션하였다. pMON13189 DNA를 미리 NcoI 및 SnaBI에 의해 분해하여, 서열을 코딩하는 hIL-3 수용체 아고니스트 pMON13416을 제거하고, 0.8TAE 겔 상에서 용해하고 에티디움 브로마이드로 염색한 후 Geneclean(Bio101, Vista, CA)을 사용하여 4254 염기쌍 벡터 단편을 분리하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON31104로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON31104로 형질전환하였다.

플라스미드 pMON31104는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:9)의 DNA 서열을 함유한다:

Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met

Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala

Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg

Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg

His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln

Gln Gly Gly Gly Ser Asn Cys Ser Ile Met Ile Asp Glu Ile Ile

His His Leu Lys Arg Pro Pro Ala Pro Leu Tyr Val Glu Gly Gly

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly

Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val

Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser

Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly

Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala

Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met

Ala Pro Ala Leu Gln Pro (SEQ ID NO:492)

실시예 76

pMON31105의 구성

재료 및 방법란에 기술된 Method III를 사용하여 pMON31105 내의 새로운 N-말단/C-말단 유전자를 만들었다. hIL-3 수용체 아고니스트 pMON13416의 전체길이의 새로운 N-말단/C-말단 유전자를 만들고, 프라이머 세트 70 스타트(SEQ ID NO:358) 및 69 rev(SEQ ID NO:359)을 사용하여 중간 플라스미드 Syntan1로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 SnaBI에 의해 분해하였다. 분해된 DNA 단편을 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 정제되고 분해된 DNA 단편을 T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 발현 벡터 pMON13189로 라이게이션하였다. pMON13189 DNA를 미리 NcoI 및 SnaBI에 의해 분해하여, 서열을 코딩하는 hIL-3 수용체 아고니스트 pMON13416을 제거하고, 0.8TAE 겔 상에서 용해하고 에티디움 브로마이드로 염색한 후 Geneclean(Bio101, Vista, CA)을 사용하여 4254 염기쌍 벡터 단편을 분리하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON31105로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON31105로 형질전환하였다.

플라스미드 pMON31105는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:10)의 DNA 서열을 함유한다:

Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys

Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile

Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr

Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Tyr Val Glu Gly Gly

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly

Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val

Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser

Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly

Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala

Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met

Ala Pro Ala Leu Gln Pro (SEQ ID NO:493)

실시예 77

pMON31106의 구성

재료 및 방법란에 기술된 Method III를 사용하여 pMON31106 내의 새로운 N-말단/C-말단 유전자를 만들었다. hIL-3 수용체 아고니스트 pMON13416의 전체길이의 새로운 N-말단/C-말단 유전자를 만들고, 프라이머 세트 91 스타트(SEQ ID NO:360) 및 90 rev(SEQ ID NO:361)을 사용하여 중간 플라스미드 Syntan1로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 SnaBI에 의해 분해하였다. 분해된 DNA 단편을 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 정제되고 분해된 DNA 단편을 T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 발현 벡터 pMON13189로 라이게이션하였다. pMON13189 DNA를 미리 NcoI 및 SnaBI에 의해 분해하여, 서열을 코딩하는 hIL-3 수용체 아고니스트 pMON13416을 제거하고, 0.8TAE 겔 상에서 용해하고 에티디움 브로마이드로 염색한 후 Geneclean(Bio101, Vista, CA)을 사용하여 4254 염기쌍 벡터 단편을 분리하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON31106으로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON31106으로 형질전환하였다.

플라스미드 pMON31106은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:11)의 DNA 서열을 함유한다:

Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln

Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln

Ala Gln Glu Gln Gln Gly Gly Gly Ser Asn Cys Ser Ile Met Ile

Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu

Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met Asp

Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val

Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn

Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Tyr Val Glu Gly Gly

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly

Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val

Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser

Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly

Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala

Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met

Ala Pro Ala Leu Gln Pro (SEQ ID NO;494)

실시예 78

pMON31107의 구성

재료 및 방법란에 기술된 Method III를 사용하여 pMON31107 내의 새로운 N-말단/C-말단 유전자를 만들었다. hIL-3 수용체 아고니스트 pMON13416의 전체길이의 새로운 N-말단/C-말단 유전자를 만들고, 프라이머 세트 101 스타트(SEQ ID NO:362) 및 100 rev(SEQ ID NO:363)을 사용하여 중간 플라스미드 Syntan1로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 SnaBI에 의해 분해하였다. 분해된 DNA 단편을 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 정제되고 분해된 DNA 단편을 T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 발현 벡터 pMON13189로 라이게이션하였다. pMON13189 DNA를 미리 NcoI 및 SnaBI에 의해 분해하여, 서열을 코딩하는 hIL-3 수용체 아고니스트 pMON13416을 제거하고, 0.8TAE 겔 상에서 용해하고 에티디움 브로마이드로 염색한 후 Geneclean(Bio101, Vista, CA)을 사용하여 4254 염기쌍 벡터 단편을 분리하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON31107로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON31107로 형질전환하였다.

플라스미드 pMON31107은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:12)의 DNA 서열을 함유한다:

Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu

Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser Asn

Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro

Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val

Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser

Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu

Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala

Ala Pro Ser Arg His Pro Ile Ile Ile Lys Tyr Val Glu Gly Gly

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala

Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly

Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val

Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser

Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly

Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala

Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met

Ala Pro Ala Leu Gln Pro (SEQ ID NO:495)

실시예 79

pMON31108의 구성

재료 및 방법란에 기술된 Method III를 사용하여 pMON31108 내의 새로운 N-말단/C-말단 유전자를 만들었다. hIL-3 수용체 아고니스트 pMON13416의 전체길이의 새로운 N-말단/C-말단 유전자를 만들고, 프라이머 세트 35 스타트(SEQ ID NO:356) 및 34 rev(SEQ ID NO:357)을 사용하여 중간 플라스미드 Syntan3으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 SnaBI에 의해 분해하였다. 분해된 DNA 단편을 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 정제되고 분해된 DNA 단편을 T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 발현 벡터 pMON13189로 라이게이션하였다. pMON13189 DNA를 미리 NcoI 및 SnaBI에 의해 분해하여, 서열을 코딩하는 hIL-3 수용체 아고니스트 pMON13416을 제거하고, 0.8TAE 겔 상에서 용해하고 에티디움 브로마이드로 염색한 후 Geneclean(Bio101, Vista, CA)을 사용하여 4254 염기쌍 벡터 단편을 분리하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON31108로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON31108로 형질전환하였다.

플라스미드 pMON31108은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:13)의 DNA 서열을 함유한다:

Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met

Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala

Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg

Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg

His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln

Gln Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn Cys

Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro

Ala Pro Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro

Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu

Ser His Lys Ser Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala

Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe

Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly

Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp

Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly

Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu

Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu

Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp

Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro (SEQ ID NO:496)

실시예 80

pMON31109의 구성

재료 및 방법란에 기술된 Method III를 사용하여 pMON31109 내의 새로운 N-말단/C-말단 유전자를 만들었다. hIL-3 수용체 아고니스트 pMON13416의 전체길이의 새로운 N-말단/C-말단 유전자를 만들고, 프라이머 세트 70 스타트(SEQ ID NO:358) 및 69 rev(SEQ ID NO:359)을 사용하여 중간 플라스미드 Syntan3으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 SnaBI에 의해 분해하였다. 분해된 DNA 단편을 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 정제되고 분해된 DNA 단편을 T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 발현 벡터 pMON13189로 라이게이션하였다. pMON13189 DNA를 미리 NcoI 및 SnaBI에 의해 분해하여, 서열을 코딩하는 hIL-3 수용체 아고니스트 pMON13416을 제거하고, 0.8TAE 겔 상에서 용해하고 에티디움 브로마이드로 염색한 후 Geneclean(Bio101, Vista, CA)을 사용하여 4254 염기쌍 벡터 단편을 분리하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON31109로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON31109로 형질전환하였다.

플라스미드 pMON31109는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:14)의 DNA 서열을 함유한다:

Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys

Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile

Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr

Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser

Gly Gly Gly Ser Gly Gly Gly Ser Asn Cys Ser Ile Met Ile Asp

Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp

Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met Asp Arg

Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys

Asn Leu Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro

Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu

Ser His Lys Ser Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala

Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe

Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly

Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp

Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly

Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu

Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu

Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp

Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro (SEQ ID NO:497)

실시예 81

pMON31110의 구성

재료 및 방법란에 기술된 Method III를 사용하여 pMON31110 내의 새로운 N-말단/C-말단 유전자를 만들었다. hIL-3 수용체 아고니스트 pMON13416의 전체길이의 새로운 N-말단/C-말단 유전자를 만들고, 프라이머 세트 91 스타트(SEQ ID NO:360) 및 90 rev(SEQ ID NO:361)을 사용하여 중간 플라스미드 Syntan3으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 SnaBI에 의해 분해하였다. 분해된 DNA 단편을 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 정제되고 분해된 DNA 단편을 T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 발현 벡터 pMON13189로 라이게이션하였다. pMON13189 DNA를 미리 NcoI 및 SnaBI에 의해 분해하여, 서열을 코딩하는 hIL-3 수용체 아고니스트 pMON13416을 제거하고, 0.8TAE 겔 상에서 용해하고 에티디움 브로마이드로 염색한 후 Geneclean(Bio101, Vista, CA)을 사용하여 4254 염기쌍 벡터 단편을 분리하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON31110으로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON31110으로 형질전환하였다.

플라스미드 pMON31110은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:15)의 DNA 서열을 함유한다:

Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln

Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln

Ala Gln Glu Gln Gln Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly

Gly Ser Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu

Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp

Glu Asp Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn

Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser

Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser

Ala Thr Ala Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro

Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu

Ser His Lys Ser Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala

Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe

Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly

Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp

Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly

Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu

Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu

Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp

Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro (SEQ ID NO:498)

실시예 82

pMON31111의 구성

재료 및 방법란에 기술된 Method III를 사용하여 pMON31111 내의 새로운 N-말단/C-말단 유전자를 만들었다. hIL-3 수용체 아고니스트 pMON13416의 전체길이의 새로운 N-말단/C-말단 유전자를 만들고, 프라이머 세트 101 스타트(SEQ ID NO:362) 및 100 rev(SEQ ID NO:363)을 사용하여 중간 플라스미드 Syntan3으로부터 증폭시켰다.

새로운 유전자를 함유하는 결과되는 DNA 단편을 제한 엔도뉴클레아제 NcoI 및 SnaBI에 의해 분해하였다. 분해된 DNA 단편을 1TAE 겔 상에서 용해하고, 에티디움 브로마이드로 염색하고, Geneclean(Bio101, Vista, CA)을 사용하여 분리하였다. 정제되고 분해된 DNA 단편을 T4 DNA 리가제(Boehringer Mannheim, Indianapolis, IN)를 사용하여 발현 벡터 pMON13189로 라이게이션하였다. pMON13189 DNA를 미리 NcoI 및 SnaBI에 의해 분해하여, 서열을 코딩하는 hIL-3 수용체 아고니스트 pMON13416을 제거하고, 0.8TAE 겔 상에서 용해하고 에티디움 브로마이드로 염색한 후 Geneclean(Bio101, Vista, CA)을 사용하여 4254 염기쌍 벡터 단편을 분리하였다. 라이게이션 반응물의 일부를 E. coli 균주 DH5α 세포(Life Technologies, Gaithersburg, MD)를 형질전환하는데 사용하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고 서열화하여 정확한 삽입을 확인하였다. 결과되는 플라스미드를 pMON31111로 표시하였다.

단백질 발현과 봉입체로부터의 단백질 분리를 위해 E. coli 균주 JM101을 pMON31111로 형질전환하였다.

플라스미드 pMON31111은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:16)의 DNA 서열을 함유한다:

Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu

Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser Gly

Gly Gly Ser Gly Gly Gly Ser Asn Cys Ser Ile Met Ile Asp Glu

Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro

Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met Asp Arg Asn

Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn

Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln

Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile

Ile Ile Lys Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro

Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu

Ser His Lys Ser Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala

Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe

Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly

Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp

Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly

Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu

Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu

Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp

Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro (SEQ ID NO:499)

실시예 83

pMON31112의 구성

hIL-3 수용체 및 G-CSF 수용체를 활성화하는 다기능 조혈 수용체 아고니스트를 암호화하는 DNA 서열을 함유하는 플라스미드, pMON31112의 구성. 플라스미드, pMON13189 DNA를 제한효소 NcoI 및 XmaI에 의해 분해하고, 이로 인해 NcoI, XmaI 벡터 단편을 얻어, 0.8아가로스 겔로부터 분리 및 정제하였다. 제 2 플라스미드, pMON13222(WO 94/12639, US 일련 # 08/411,796)로부터의 DNA를 NcoI 및 EcoRI에 의해 분해하고, 이로 인해 281 염기쌍 NcoI, EcoRI 단편을 얻었다. 이 단편을 1.0아가로스 겔로부터 분리 및 정제하였다. 2가지 올리고뉴클레오티드 SYNNOXA1.REQ(SEQ ID NO:350) 및 SYNNOXA2.REQ(SEQ ID NO:351)를 어닐링하고, pMON13222로부터의 281 염기쌍 DNA 단편과 라이게이션하여 pMON13189로부터의 DNA 벡터 단편을 얻었다. 그리고나서, 라이게이션 혼합물의 일부를 E. coli K-12 균주 JM101로 형질전환하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고, 제한분석에 의해 분석하여 EcoRV 단편의 존재를 알았고, 서열화하여 정확한 삽입을 확인하였다.

플라스미드, pMON31112는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:37)의 DNA 서열을 함유한다:

MetAlaAsnCysSerAsnMetIleAspGluIleIleThrHisLeuLysGlnProProLeuPro LeuLeuAspPheAsnAsnLeuAsnGlyGluAspGlnAspIleLeuMetAspAsnAsnLeuArg ArgProAsnLeuGluAlaPheAsnArgAlaValLysSerLeuGlnAsnAlaSerAlaIleGlu SerIleLeuLysAsnLeuLeuProCysLeuProLeuAlaThrAlaAlaPro ThrArgHisProIleHisIleLysAspGlyAspTrpAsnGluPheArgArgLysLeuThrPhe TyrLeuLysThrLeuGluAsnAlaGlnAlaGlnGlnTyrValGluGlyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLys SerProAsnMetAlaThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAla GlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArg HisLeuAlaGlnProSerGlyGlySerGlyGlySerGlnSerPheLeuLeuLysSerLeuGlu GlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLys LeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeu SerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeu PheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeu AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeu GlyMetAlaProAlaLeuGlnPro (SEQ ID NO:505)

실시예 84

pMON31113의 구성

hIL-3 수용체 및 G-CSF 수용체를 활성화하는 다기능 조혈 수용체 아고니스트를 암호화하는 DNA 서열을 함유하는 플라스미드, pMON31113의 구성. 플라스미드, pMON13197 DNA를 제한효소 NcoI 및 XmaI에 의해 분해하고, 이로 인해 NcoI, XmaI 벡터 단편을 얻어, 0.8아가로스 겔로부터 분리 및 정제하였다. 제 2 플라스미드, pMON13239(WO 94/12639, US 일련 # 08/411,796)로부터의 DNA를 NcoI 및 EcoRI에 의해 분해하고, 이로 인해 281 염기쌍 NcoI, EcoRI 단편을 얻었다. 이 단편을 1.0아가로스 겔로부터 분리 및 정제하였다. 2가지 올리고뉴클레오티드 SYNNOXA1.REQ(SEQ ID NO:350) 및 SYNNOXA2.REQ(SEQ ID NO:351)를 어닐링하고, pMON13239로부터의 281 염기쌍 DNA 단편과 라이게이션하여 pMON13197로부터의 DNA 벡터 단편을 얻었다. 그리고나서, 라이게이션 혼합물의 일부를 E. coli K-12 균주 JM101로 형질전환하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고, 제한분석에 의해 분석하여 EcoRV 단편의 존재를 알았고, 서열화하여 정확한 삽입을 확인하였다.

플라스미드, pMON31113은 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:38)의 DNA 서열을 함유한다:

MetAlaAsnCysSerAsnMetIleAspGluIleIleThrHisLeuLysGlnProProLeuPro LeuLeuAspPheAsnAsnLeuAsnGlyGluAspGlnAspIleLeuMetGluAsnAsnLeuArg ArgProAsnLeuGluAlaPheAsnArgAlaValLysSerLeuGlnAsnAlaSerAlaIleGlu SerIleLeuLysAsnLeuLeuProCysLeuProLeuAlaThrAlaAlaProThrArgHisPro IleIleIleArgAspGlyAspTrpAsnGluPheArgArgLysLeuThrPheTyrLeuLysThr LeuGluAsnAlaGlnAlaGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSer GlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMet AlaThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeu ValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGln ProThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGl ValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeu CysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSer SerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPhe LeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAsp ThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGly MetAlaProAlaLeuGlnPro (SEQ ID NO:506)

실시예 85

pMON31114의 구성

hIL-3 수용체 및 G-CSF 수용체를 활성화하는 다기능 조혈 수용체 아고니스트를 암호화하는 DNA 서열을 함유하는 플라스미드, pMON31114의 구성. 플라스미드, pMON13189 DNA를 제한효소 NcoI 및 XmaI에 의해 분해하고, 이로 인해 NcoI, XmaI 벡터 단편을 얻어, 0.8아가로스 겔로부터 분리 및 정제하였다. 제 2 플라스미드, pMON13239(WO 94/12639, US 일련 # 08/411,796)로부터의 DNA를 NcoI 및 EcoRI에 의해 분해하고, 이로 인해 281 염기쌍 NcoI, EcoRI 단편을 얻었다. 이 단편을 1.0아가로스 겔로부터 분리 및 정제하였다. 2가지 올리고뉴클레오티드 SYNNOXA1.REQ(SEQ ID NO:350) 및 SYNNOXA2.REQ(SEQ ID NO:351)를 어닐링하고, pMON13239로부터의 281 염기쌍 DNA 단편과 라이게이션하여 pMON13189로부터의 DNA 벡터 단편을 얻었다. 그리고나서, 라이게이션 혼합물의 일부를 E. coli K-12 균주 JM101로 형질전환하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고, 제한분석에 의해 분석하여 EcoRV 단편의 존재를 알았고, 서열화하여 정확한 삽입을 확인하였다.

플라스미드, pMON31114는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:39)의 DNA 서열을 함유한다:

MetAlaAsnCysSerAsnMetIleAspGluIleIleThrHisLeuLysGlnProProLeuPro LeuLeuAspPheAsnAsnLeuAsnGlyGluAspGlnAspIleLeuMetGluAsnAsnLeuArg ArgProAsnLeuGluAlaPheAsnArgAlaValLysSerLeuGlnAsnAlaSerAlaIleGlu SerIleLeuLysAsnLeuLeuProCysLeuProLeuAlaThrAlaAla ProThrArgHisProIleIleIleArgAspGlyAspTrpAsnGluPheArgArgLysLeuThr PheTyrLeuLysThrLeuGluAsnAlaGlnAlaGlnGlnTyrValGluGlyGlyGlyGlySer ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHis LysSerProAsnMetAlaThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArg AlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeu ArgHisLeuAlaGlnProSerGlyGlySerGlyGlySerGlnSerPheLeuLeuLysSerLeu GluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyr LysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaPro LeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGly LeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThr LeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGlu LeuGlyMetAlaProAlaLeuGlnPro (SEQ ID NO:507)

실시예 86

pMON31115의 구성

hIL-3 수용체 및 G-CSF 수용체를 활성화하는 다기능 조혈 수용체 아고니스트를 암호화하는 DNA 서열을 함유하는 플라스미드, pMON31115의 구성. 플라스미드, pMON13197 DNA를 제한효소 NcoI 및 XmaI에 의해 분해하고, 이로 인해 NcoI, XmaI 벡터 단편을 얻어, 0.8아가로스 겔로부터 분리 및 정제하였다. 제 2 플라스미드, pMON13222로부터의 DNA를 NcoI 및 EcoRI에 의해 분해하고, 이로 인해 281 염기쌍 NcoI, EcoRI 단편을 얻었다. 이 단편을 1.0아가로스 겔로부터 분리 및 정제하였다. 2가지 올리고뉴클레오티드 SYNNOXA1.REQ(SEQ ID NO:350) 및 SYNNOXA2.REQ(SEQ ID NO:351)를 어닐링하고, pMON13222로부터의 281 염기쌍 DNA 단편과 라이게이션하여 pMON13197로부터의 DNA 벡터 단편을 얻었다. 그리고나서, 라이게이션 혼합물의 일부를 E. coli K-12 균주 JM101로 형질전환하였다. 형질전환체 세균을 암피실린함유 플레이트 상에서 선택하였다. 플라스미드 DNA를 분리하고, 제한분석에 의해 분석하여 EcoRV 단편의 존재를 알았고, 서열화하여 정확한 삽입을 확인하였다.

플라스미드, pMON31115는 다음의 아미노산 서열을 암호화하는 (SEQ ID NO:40)의 DNA 서열을 함유한다:

MetAlaAsnCysSerAsnMetIleAspGluIleIleThrHisLeuLysGlnProProLeuPro LeuLeuAspPheAsnAsnLeuAsnGlyGluAspGlnAspIleLeuMetAspAsnAsnLeuArg ArgProAsnLeuGluAlaPheAsnArgAlaValLysSerLeuGlnAsnAlaSerAlaIleGlu SerIleLeuLysAsnLeuLeuProCysLeuProLeuAlaThrAlaAlaProThrArgHisPro IleHisIleLysAspGlyAspTrpAsnGluPheArgArgLysLeuThrPheTyrLeuLysThr LeuGluAsnAlaGlnAlaGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSer GlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMet AlaThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeu ValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGln ProThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGln ValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeu CysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSer SerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPhe LeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAsp ThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGly MetAlaProAlaLeuGlnPro (SEQ ID NO:508)

실시예 87

다기능 조혈 수용체 아고니스트 단백질의 시험관내의 활성의 측정

정제된 친화성 폴리클론성 항체에 근거한 샌드위치 ELISA를 사용하여 다기능 조혈 수용체 아고니스트 단백질의 단백질 농도를 측정할 수 있다. 다르게는 아미노산 조성 분석에 의해 단백질 농도를 측정할 수 있다. 다수의 시험관내 분석에 의해 다기능 조혈 수용체 아고니스트의 생물활성을 측정할 수 있다. 예를 들면, hIL-3 수용체와 G-CSF 수용체를 결합하는 다기능 조혈 수용체 아고니스트를 hIL-3 및/또는 G-CSF 수용체를 발현하는 세포계를 사용하는 세포증식 분석에서 분석할 수 있다. 그러한 분석 중 1가지는 AML-193 세포증식 분석이다. AML-193 세포는 IL-3/G-CSF 다기능 조혈 수용체 아고니스트의 결합된 생물활성이 측정될 수 있도록 하는 IL-3 및 G-CSF에 반응한다. 그러한 분석 중 다른 것은 TF1 세포증식 분석이다.

그 외에 마우스 IL-3 의존성 세포계인 M-NFS-60(ATCC. CRL 1838) 또는 32D와 같은 다른 인자 의존성 세포계를 사용할 수 있다. IL-3의 활성은 종특이성이고, G-CSF는 그렇지 않기 때문에, IL-3/G-CSF 다기능 조혈 수용체 아고니스트의 G-CSF 성분의 생물활성을 독립적으로 측정할 수 있다. 주어진 리간드에 대해 수용체를 발현하지 않는, BHK 또는 마우스 Baf/3와 같은 세포계를 원하는 수용체를 암호화하는 유전자를 함유하는 플라스미드로 트랜스펙션할 수 있다. 그러한 세포계의 예는 hG-CSF 수용체(BaF3/hG-CSF)로 트랜스펙션된 BaF3이다. 이들 세포계 내의 다기능 조혈 수용체 아고니스트의 활성을 hIL-3 또는 G-CSF 단독으로 또는 함께 비교할 수 있다. BaF3/hG-CSF 세포증식 및 TF1 세포증식 분석에서 분석된 본 발명의 다기능 조혈 수용체 아고니스트의 예의 생물활성이 표 5 및 표 6에 나타나 있다. 다기능 조혈 수용체 아고니스트의 생물활성은 IL-3 및 G-CSF 수용체 결합 활성을 갖는 표준 단백질 pMON13056(WO 95/21254)과 비교된 상대적인 활성으로서 발현된다. BaF3/c-mpl 세포증식 및 TF1 세포증식 분석에서 분석된 본 발명의 다기능 조혈 수용체 아고니스트의 예의 생물활성이 표 7 및 표 8에 나타나 있다.

이중 IL-3/G-CSF 수용체 아고니스트의 세포증식성 활성

pMON	BaF3/hG-CSF 수용체 세포증식 분석상대적인 활성^*	TF1세포증식 분석상대적인 활성^*
13182	0.015	1.1
13183	0.02	nd
13184	0.01	0.3
13185	0.023	0.36
13186	0.36	0.45
13187	0.07	0.26
13188	0.64	1.3
13189	0.58	1.37
13190	0.045	1.2
13191	0.14	2.7
13192	0.09	2.2
13193	0.06	3.0
25190	nd	nd
25191	0.43	1.2
13194	nd	nd
13195	1.3	4.3
13196	0.66	0.5
13197	0.6	0.77
13198	0.6	0.5
13199	nd	nd
15982	0.7	1.9
15981	0.068	1.2
15965	0.7	0.82
15966	0.36	1.48
15967	0.62	1.37
nd=측정되지 않음* 다기능 조혈 수용체 아고니스트의 생물활성이 표준 단백질 pMON13056과 비교한 상대적인 활성으로서 발현됨. n=3 또는 그보다 큼.

이중 IL-3/G-CSF 수용체 아고니스트의 세포증식성 활성

pMON	BaF3/hG-CSF 수용체 세포증식 분석상대적인 활성	TF1세포증식 분석상대적인 활성
31104	+	+
31105	+	+
31106	+	+
31107	nd	nd
31108	+	+
31109	+	+
31110	nd	nd
31111	nd	nd
31112	+	+
31113	+	+
31114	+	+
31115	+	+
31116	nd	nd
31117	nd	nd
nd=측정되지 않음† 다기능 조혈 수용체 아고니스트의 생물활성(n=1 또는 2)이 표준 단백질 pMON13056과 비교한 상대적인 활성으로서 발현됨."+"는 분자가 pMON13056에 필적한다는 것을 표시한다.

세포증식 활성

pMON	Baf3/c-mpl 수용체 세포증식 분석활성^*	TF1세포증식 분석활성
28505	-	+
28506	-	+
28507	-	+
28508	-	+
28509	-	+
28510	-	+
28511	+	+
28512	+	+
28513	+	+
28514	+	+
28519	-	+
28520	-	+
28521	-	+
28522	-	+
28523	-	+
28524	-	+
28525	+	+
28526	+	+
28533	-	+
28534	-	+
28535	-	+
28536	-	+
28537	-	+
28538	-	+
28539	+	+
28540	+	+
28541	+	+
28542	+	+
28543	+	+
28544	+	+
28545	+	+
* c-mpl 리간드(1-153)에 대한 상대적인, c-mpl 수용체로 트랜스펙션된 Baf3 세포계에서 측정된 활성.† pMON13056에 대해 상대적으로 측정된 활성.

유사한 방식으로, 원하는 다기능 조혈 수용체 아고니스트의 생물활성을 측정하기 위해 당업자에게 공지된 다른 인자 의존성 세포계를 사용할 수 있다. 조혈 전구체 세포의 팽창 및 시험관내 조혈 콜로니의 서로 다른 타입의 패턴에 대한 다기능 조혈 수용체 아고니스트의 영향을 측정하기 위해 메틸셀룰로스 분석을 사용할 수 있다. 메틸셀룰로스 분석은 100,000 입력 세포당 전구체의 빈도를 측정하기 때문에 전구체 빈도의 평가를 제공할 수 있다. 장기적인 스트로말 의존성 배양을 원시 조혈 전구체 및 줄기 세포를 묘사하는데 사용하였다. 이 분석은 다기능 조혈 수용체 아고니스트가 매우 원시적인 전구체 및/또는 줄기 세포의 팽창을 자극하는지의 여부를 결정하는데 사용될 수 있다. 그 외에, 다기능 조혈 수용체 아고니스트에 의해 자극된 원시 전구체의 빈도를 나타내는 희석 배양물을 제한할 수 있다.

pMON #	IL-3 아고니스트 활성(AML 세포증식 분석)	c-mpl 수용체 아고니스트 활성(Baf/3-c-mpl 세포증식 분석)
28505	+	-
28506	+	-
28507	+	-
28508	+	-
28509	+	-
28510	+	-
28511	+	+
28512	+	+
28513	+	+
28514	+	+
28515	+	+
28519	+	-
28520	+	-
28521	+	-
28522	+	-
28523	+	-
28524	+	-
28525	+	+
28526	+	+
28527	+	+
28528	+	+
28529	+	+
28535	+	-
28539	+	+
28540	+	+
28541	+	+
28542	+	+
28545	+	+
28551	+	+
28571	+	+

실시예 88

WO 94/12639 및 WO 94/12638에 기재된 PCR 돌연변이유발 기법을 사용하여 단일 또는 다중 아미노산 치환체를 함유하는 G-CSF 변이체를 만들었다. 또한, 합성 유전자 조립 또는 특정부위의 돌연변이 유발(Taylor et al., Nucl. Acids Res., 13: 7864-8785[1985]; Kunkel et al., Proc. Natl. Acad. Sci. USA, 82: 488-492[1985]; Sambrook et al., Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, [1989], (WO 94/12639) 및 (WO 94/12638) 참조)을 포함하는 다양한 다른 방법을 사용하여 당업자에 의해 이들 변이체 및 다른 변이체(즉, 아미노산 치환체, 삽입체 또는 결실체 그리고 N-말단 또는 C-말단 연장체)를 만들 수 있었다. 동시에 또는 다른 아미노산 치환체, 및/또는 결실체, 및/또는 삽입체 및/또는 연장체와 조합하여 이들 치환체를 하나로 만들 수 있다. 변화체의 서열 확인 후에, 플라스미드 DNA를 트랜스펙션하여 적절한 포유동물 세포, 곤충 세포 또는 생성을 위한 E. coli와 같은 균주를 얻을 수 있다. 활성인 G-CSF의 공지의 변이체는 위치 1(Thr 내지 Ser, Arg 또는 Gly), 2(Pro 내지 Leu), 3(Leu 내지 Arg 또는 Ser) 및 17(Cys 내지 Ser)에서의 치환체 그리고 아미노산 1-11의 결실체를 포함한다(Kuga et al. Biochemical and Biophysical Research Comm. 159:103-111(1989)). 새로운 N-말단 및 새로운 C-말단이 만들어진 G-CSF 수용체 아고니스트를 만들기 위한 주형으로서, 이 G-CSF 아미노산 치환 변이체를 사용할 수 있다. G-CSF 아미노산 치환 변이체의 예가 표 9에 나타나 있다.

실시예 89

G-CSF 아미노산 치환 변이체의 생물활성 측정

사람 G-CSF 수용체로 트랜스펙션된 Baf/3 세포계를 사용하여 G-CSF 아미노산 치환 변이체를 세포증식 활성에 대해 분석할 수 있다. G-CSF 아미노산 치환 변이체의 예의 생물활성이 천연 사람 G-CSF와 비교되어 표 9에 나타나 있다. "+"는 천연 G-CSF에 비해 활성이 높다는 것을 나타내고, "-"는 현저히 감소하거나 또는 측정가능한 활성을 보이지 않는다는 것을 나타낸다.

사람 G-CSF 수용체로 트랜스펙션된 BAF3 세포계 내에서의 G-CSF 변이체의 세포증식 활성

aa 위치	천연 aa	돌연변이체 aa	활성^*
13	Phe	Ser	+
13	Phe	His	+
13	Phe	Thr	+
13	Phe	Pro	+
16	Lys	Pro	+
16	Lys	Ser	+
16	Lys	Thr	+
16	Lys	His	+
18	Leu	Pro	+
18	Leu	Thr	+
18	Leu	His	+
18	Leu	Cys	+
18	Leu	Ile	+
19	Glu	Ala	-
19	Glu	Thr	-
19	Glu	Arg	-
19	Glu	Pro	-
19	Glu	Leu	-
19	Glu	Ser	-
22	Arg	Tyr	+
22	Arg	Ser	+
22	Arg	Ala	+
22	Arg	Thr	+
24	Ile	Pro	+
24	Ile	Leu	+
24	Ile	Tyr	+

aa 위치	천연 aa	돌연변이체 aa	활성
27	Asp	Gly	+
30	Ala	Ile	+
30	Ala	Leu	+
34	Lys	Ser	+
43	His	Gly	+
43	His	Thr	+
43	His	Val	+
43	His	Lys	+
43	His	Trp	+
43	His	Ala	+
43	His	Arg	+
43	His	Cys	+
43	His	Leu	+
44	Pro	Arg	+
44	Pro	Asp	+
44	Pro	Val	+
44	Pro	Ala	+
44	Pro	His	+
44	Pro	Gln	+
44	Pro	Trp	+
44	Pro	Gly	+
44	Pro	Thr	+
46	Glu	Ala	+
46	Glu	Arg	+
47	Leu	Thr	+
49	Leu	Phe	+
49	Leu	Arg	+
49	Leu	Ser	+
50	Leu	His	+
54	Leu	His	+

aa 위치	천연 aa	돌연변이체 aa	활성
67	Gln	Lys	+
67	Gln	Leu	+
67	Gln	Cys	+
70	Gln	Pro	+
70	Gln	Leu	+
70	Gln	Arg	+
70	Gln	Ser	+
104	Asp	Gly	+
104	Asp	Val	+
108	Leu	Ala	+
108	Leu	Val	+
108	Leu	Arg	+
108	Leu	Gly	+
108	Leu	Trp	+
108	Leu	Gln	+
115	Thr	His	+
115	Thr	Leu	+
115	Thr	Ala	+
144	Phe	His	+
144	Phe	Arg	+
144	Phe	Pro	+
144	Phe	Leu	+
144	Phe	Glu	+
146	Arg	Gln	+
147	Arg	Gln	+
156	His	Asp	-
156	His	Ser	+
156	His	Gly	+
159	Ser	Arg	+
159	Ser	Thr	+
159	Ser	Tyr	+
159	Ser	Val	+
159	Ser	Gly	+
162	Glu	Gly	-
162	Glu	Trp	+
162	Glu	Leu	+
163	Val	Arg	+
163	Val	Ala	+
163	Val	Gly	+
165	Tyr	Cys	nd
169	Ser	Leu	+
169	Ser	Cys	+
169	Ser	Arg	+
170	His	Arg	+
170	His	Ser	+
* 천연 hG-CSF에 대해 상대적인 활성nd=측정되지 않음

실시예 90

flt3 리간드를 암호화하는 cDNA의 분리

NCOFLT, HIND160 및 HIND165 PCR 프라이머를 사용하여(제조업자가 제안한 조건에 따라서), 사람 골수 폴리 A+ RNA(Clontech)로부터 3개의 flt3 리간드 클론을 증폭하였다. 이 증폭된 PCR 생성물을 겔 정제하고, pMON30237(NCOFLT+HIND160), pMON30238(NCOFLT+HIND165) 및 결실 클론 pMON30239(NCOFLT+HIND165)를 생성하는 BHK 발현 벡터 pMON5723으로 클로닝하였다. pMON30239 내의 결실은 아미노산 잔기 89 내지 106의 결실이다.

실시예 91

서열 재배열된 flt3 수용체 아고니스트는 몇가지 방법과 링커형을 사용하여 구성되었다. 절단점 39/40, 65/66 및 89/90을 가진 링커 펩티드 (SerGlyGlyAsnGly)X (여기서×= 1, 2, 또는 3)를 함유하는 구조물의 첫 세트는 Mullins et al.에 설명되어진 두 단계의 PCR 방법을 사용하여 제조되었다. 이 방법에서, 각 마지막 서열 재배열된 분자의 앞부분의 반과 뒷부분 반은 첫번째 PCR 단계에서 별도로 제작되었고, 그 다음, 첫 반응 단계에서 짝지워진 생성물은 두번째 PCR 단계에서 결합되고 외부 프라이머 없이 연장된다.

예를 들어 SerGlyGlyAsnGly SEQ ID NO:786, SerGlyGlyAsnGlySerGlyGlyAsnGly SEQ ID NO:787, 및 SerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGly SEQ ID NO:788 아미노산 링커 (각각 pMON32326, pMON32327 및 pMON32328)를 가진 세개의 89/90 절단점 전구체 분자를 제조하기 위해, 여섯개의 초기 PCR 생성물을 생성시켰다. 다음의 프라이머 쌍이 첫 단계 PCR 반응에 사용되었다: a) 89For/L5B; b) 89For/L10B; c) 89For/L15B; d) 89Rev/L5A; e) 89Rev/L10A; 및 f) 89Rev/L15A. 동일한 접근법을 pMON32321 (39/40 절단점, 프라이머 쌍 39For/L10B 및 39Rev/L10A)와 pMON32325 (65/66 절단점, 프라이머 쌍 65For/L5B 및 65Rev/L5A) 전구체를 만드는 데 사용하였다. 아래에 언급되는 것을 제외하고, 모든 이어서 일어나는 PCR 반응은 제조자가 제안한 프로토콜에 따른 증폭 조건과 PCR Optimizer Kit (Invitrogen)의 구성요소를 이용했다. 반응은 다음과 같이 세웠다: 각 프라이머 50 pmol, 5X 완충액 B [300 mM Tris-HCl (pH 8.5), 10 mM MgCl₂, 75 mM (NH₄)2SO₄] 10 ul, Taq 폴리머라제 5U, 및 열 변성된 DNA 주형(이 실시예에서는 pMON30238) 100 ng을 결합하고, dH₂O로 45 ul의 마지막 부피가 되도록 맞춘다. 반응물은 80℃에서 1-5분동안 예비배양한 후, 10 mM dNTP의 5 ul를 각 반응에 가하고, Perkin Elmer model 480 DNA thermal cycler에서 증폭시키기에 앞서 94℃에서 2 분간 열변성시켰다. 7개의 DNA 증폭 사이클이 다음의 조건에서 수행되었다: 94℃에서 1분간 열변성, 65℃에서 2분간 어닐링, 이어서 72℃에서 3분간 연장. 94℃에서 1분간 열변성, 이어서 72℃에서 4분간 어닐링/연장으로 구성되는 23번의 사이클이 더 수행되었고, 이어서 72℃에서 마지막 7분간 연장 사이클이 수행되었다. pMON32328을 제외하고, PCR 증폭 생성물을 1.2 TAE 아가로스 겔 상에서 유출시켰고, 적당한 크기의 밴드(주 증폭 생성물)을 절단하여 Geneclean II (Bio 101)을 사용하여 정제하였다. 샘플을 10 ul dH2O에 재현탁시켰다. pMON32328의 증폭생성물은 Wizard PCR Clean Up 키트 (Promega)를 사용하여 직접 정제하였고, DNA를 50 ul의 dH₂O에서 용출했다.

pMON32322 (39/40 절단점, 프라이머 쌍 39For/L5B 및 39Rev/L5A)의 전구체를 구성하는 방법은 주형의 양을 1 ug까지 증가시킴에 의해서, 그리고 PCR 증폭 조건을 다음과 같이 변화시킴에 의해서 변형되었다: 94℃에서 1분간, 65℃에서 2분간, 그리고 72℃에서 2 1/2분간의 6 사이클, 이어서 94℃에서 1분간, 70℃에서 2분간, 그리고 72℃에서 2 분간의 15 사이클, 이어서 7분동안 72℃ 연장 사이클 1회.

두번째 PCR 단계는 다음과 같은 프라이머/주형의 결합물로서 첫 PCR 단계에서 나온 겔-정제된 전구체를 사용하였다: 각 전구체 분자의 각 5 ul (즉, pMON32328을 위해서 프라이머 쌍 89For/L5B 및 89Rev/L5A로부터의 PCR 생성물), 5X 완충액 B 10 ul, Taq 폴리머라제 5 U, dH₂O 24 ul. 반응물을 80℃에서 5분동안 가열하고, 10 mM dNTP의 5 ul를 가하고,그 반응물을 94℃에서 2 분간 열변성시켰다. DNA 증폭조건은 다음과 같다. 94℃에서 1분간, 69℃에서 2분간의 15 사이클, 이어서 그다음 72℃에서 3분간의 연장. 완전한 연장을 고려하여, 마지막 사이클은 72℃에서 7분동안 1회의 연장 단계가 따라졌다. 80 도 배양 시간은 2분으로 축소하고 사이클의 수는 pMON32325 (PCR 생성물 65For/L5B 및 65Rev/L5A)를 위해서 10 사이클로 감소시켰다. 적당한 크기의 PCR 반응 생성물을 1.2 TAE 아가로스 겔 상에서 Geneclean II를 사용하여 겔 정제하였다. pMON32322 (39For/L5B 및 39Rev/L5A)를 위해서, 어닐링 온도를 68℃로 낮췄고, 연장시간은 2분으로 단축하였다. 게다가 PCR 생성물은 공급자가 제안한 프로토콜에 따라서 Wizard PCR Clean Up 키트 (Promega)를 사용하여 정제하였다. 두 번째 PCR 단계는 pMON32326 (89For/L15B 및 89Rev/L15A의 PCR 생성물)를 위해서 다음과 같이 변형되었다. 샘플 완충액 타입 (5X 완충액 B, D, 또는 J -PCR Optimizer 키트)를 제외하고 PCR 반응물의 세개의 세트는 상기와 같이 동일하게 세워졌다. 완충액 D와 J의 조성은 단지 pH또는 [MgCl₂]에서만 완충액 B와 다르다. 완충액 J의 pH가 9.5인 반면, 완충액 D의 [MgCl₂]은 3.5 mM이다. 프로토콜은 PCR 사이클의 수를 20으로 증가시킴에 의해서 변형되었고, 사이클 10, 15 및 20이 끝날 때 15 ul 분취량을 들어내었다. 각 시간점의 분취량 5 ul은 1.2 TBE 아가로스 겔 상에서 증폭된 물질의 존재를 분석하였다. 완충액 B, D, J PCR 반응 혼합물의 잔여물을 모으고, 이어서 Wizard PCR Clean Up 키트 프로토콜을 사용하여 정제하였다. DNA를 50 ul의 dH₂O에서 용출했다.

두번째 단계 PCR 반응으로부터 정제된 샘플은 두개의 표준화한 절단 조건 중 하나를 사용하여 NcoI/HindIII로 절단하였다. Geneclean II 정제 샘플을 위해서, DNA 10 ul를 37℃에서 두시간동안 NcoI/HindIII의 각 7.5 U을 사용하여 20 ul의 반응물에서 절단하였고, 1.1 TAE 아가로스 겔 상에서 Geneclean II를 사용하여 겔 정제하였다. 라이게이션 준비 샘플을 10 ul dH₂O에서 재현탁하였다. pMON32322를 위해서, 샘플 20 ul를 37℃에서 3시간동안 NcoI와 HindIII를 각각 20 U을 사용하여 50 ul의 반응물 부피에서 절단하였다. 3 M NaOAc (pH 5.5) 0.1 부피 및 EtOH 2.5 부피를 가하고, 혼합한 후, -20℃에서 하룻밤동안 방치하였다. DNA를 Sigma Mk 202 마이크로퓨즈에서 4℃, 13,000 rpm으로 20 분간 침전시켜 원상태로 복구하였다. DNA 펠릿을 냉각시킨 70 EtOH로 헹구어내고, 동결건조하고, dH₂O 10 ul에서 재현탁시켰다.

실시예 92

또 다른 접근법이 pMON32320 (39/40 절단점, 15 아미노산 링커), pMON32323 (65/66 절단점, 15 아미노산 링커), 및 pMON32324 (65/66 절단점, 10 아미노산 링커)를 구성하기 위해 사용되었다. 새로운 프라이머 (L15C, L15D, L15E)를 BamHI 부위로 클로닝되어 적당한 리딩 프레임을 유지하기 위해 구조된 프라이머 중 BamHI 제한 부위에 결합시키는 것으로 계획하었다. 다음의 세트의 프라이머 쌍이 사용되어지는 것을 제외하고 첫 단계의 PCR 반응조건은 pMON32322를 위해 설명된 것과 동일하게 수행되었다: 65For/L15D 및 65Rev/L15E (pMON32324); 39For/L15D 및 39Rev/L15C (pMON32320); 65For/L15D 및 65Rev/L15C (pMON32323). PCR 반응 생성물은 설명한 대로 Wizard PCR Clean Up 키트를 사용하여 정제하였고, 50 ul dH₂O에서 용출하였다. 샘플은 NcoI/BamHI (39For/L15D 및 65For/L15D) 또는 BamHI/HindIII (39Rev/L15C, 65Rev/L15C 및 65Rev/L15E)로 절단하였다. 제한 절단은 다음과 같이 수행되었다: 30 ul의 마지막 반응 부피에 정제된 PCR 반응 생성물 10 ul, 10X 일반적인 제한 완충액 3 ul, NcoI 또는 HindIII 15 U, BamHI 15 U. 반응물은 37℃에서 90 분간 배양하였고, PCR 생성물은 1.1 TAE 아가로스 겔 상에서 Geneclean II를 사용하여 겔 정제하였다. 라이게이션-준비 DNA를 10 ul의 dH₂O에서 재현탁시켰다.

삽입물은 다음과 같은 세가지 방식 (pMON32320, pMON32323, 또는 pMON32324) 또는 두가지 방식 (pMON32321, pMON32322, pMON32325, pMON32326, pMON32327 및 pMON32328)의 라이게이션 반응에서 작은 새우 알카리성 포스파타제(shrimp alkaline phosphatase, SAP)로 처리한 NcoI/HindIII 절단된 pMON3977 (BHK 포유동물의 발현 벡터)에 라이게이션시켰다: 표준 라이게이션조건을 사용하여 삽입물(pMON32320, pMON32323, 또는 pMON32324를 위한 각 프라임 쌍 암플리콘 2 ul) 2.5 ul를 10 ul 반응물 중 50 ng의 벡터에 가했다. 각 반응물의 2 ul를 제조자가 제안한 프로토콜에 따라서 화학적으로 콤피턴트 DH5α 세포(Gibco/BRL) 100 ul로 형질전환시켰다. 25 ul와 200 ul의 분취량을 50 ug/ml 암피실린을 함유하는 LB 플레이트 상에 판상으로 깔고 하룻밤동안 배양하였다. 분리된 콜로니를 가려내고, DNA를 Qiagen DNA midiprep 키트를 사용하여 50 ml 하룻밤 배양물로부터 제조하였다. DNA는 A260/A280에서 흡광도를 측정하여 정량하고, 1 ug 주형을 NcoI/HindIII 제한 엔도누클레아제로 절단한 후 아가로스 겔 전기영동으로 맞는 삽입크기를 확인하였다. 예상되는 크기의 삽입물을 포함하는 샘플을 자동 형광 DNA 시퀀서 모델 373A (Perkin Elmer ABI)를 사용한 벡터-특이적 프라이머를 사용하여 양 방향에서 서열화하였다.

서열화 반응을 다음과 같이 Perkin Elmer model 480 DNA thermal cycler를 사용하여 20 ul 반응 부피에서 수행하였다: 주형 1 ug, 프라이머 3.2 pmol, DMSO 1 ul, Taq 터미네이터 디데옥시 프리믹스 (Perkin Elmer ABI) 9.5 ul를 결합하고, 다음과 같은 서열 증폭 25 사이클을 수행하였다: 94℃에서 30 초, 50℃에서 어닐링, 이어서 60℃에서 4분간 연장. 샘플을 제조자가 제안한 프로토콜에 따라 Centri-Sep 스핀 컬럼(Princetopn Separation)을 사용하여 정제하고, 동결건조하여 서열 분석 하였다. 예상되는 아미노산 서열을 함유하는 샘플을 분석을 위해 선택하였고 pMON 번호를 할당하였다.

실시예 93

pMON32320, pMON32323 및 pMON32324를 구성하기 위해 사용되었던 유사한 접근법이 두번째 링커형 (SerGlyGlySerGly)X (여기서×= 2 또는 3)을 39/40 절단점 (pMON32348 및 32350)을 함유하는 두개의 서열 재배열된 서열에 도입하는 데 사용되었다. 프라이머 쌍은 다음과 같다: pMON32348를 위해 339For2/339Rev3 및 339Rev2/339-10For3의 조합과 pMON32350을 위해 339For2/339Rev3 및 339Rev2/339-15For3의 조합이 세개의 PCR 증폭 생성물을 만들기 위해 사용되었다. 각 PCR 증폭은 다음과 같이 세워졌다: 열 변성된 pMON32320 100 ng을 위해서, 각 프라이머 쌍 50 pmol, 5X 완충액 B 10 ul, Taq 폴리머라제 5 U 및 dH₂O를 45 ul의 마지막 부피가 되도록 가했다. 반응물을 앞서 설명한대로 미리배양하였다. 15 증폭 사이클이 다음과 같은 조건 하에서 수행되었다: 94℃에서 열변성 1분, 이어서 70℃에서 2 분간의 어닐링단계, 그리고 72℃에서 3분간의 연장. 마지막 사이클 후, 7분의 72 도 연장 단계가 1회 실시되었다. 프라이머 쌍 339For2/339Rev3, 339Rev2/339-10For3, 및 339Rev2/339-15For2의 PCR 증폭생성물을 Wizard PCR Clean Up 키트를 사용하여 정제하였고, 50ul dH₂O에서 용출시켰다. NcoI/BamHI는 다음과 같이 339For2/339Rev3 프라이머 쌍을 절단한다: DNA 주형 8ul를 보편적인 제한 완충액 2 ul와 20 ul 반응 부피 중 NcoI와 BamHI 각 10 U을 혼합하였고, 37℃에서 90 분동안 배양하였다. 절단 생성물을 Geneclean II 직접 정제 프로토콜을 사용하여 정제하였고, 라이게이션 준비 DNA를 dH₂O 10 ul에서 재현탁하였다. HindIII 10 U이 NcoI로 대체된 것을 제외하고, 339Rev2/339-10For3 및 339Rev2/339-15For2 증폭 생성물을 위한 제한 절단과 그 다음의 정제가 339For2/339Rev3 암플리콘에서 설명된 것과 동일하게 수행되었다. 표준 라이게이션을 50 ng NcoI/HindIII/SAP-처치한, 겔 정제된 pMON3977 50 ng, 339For2/Rev3 암플리콘 0.5 ul, 339Rev2/339-10For3 (pMON32348) 또는 339Rev2/339-15For3 (pMON32350) 암플리콘 1 ul, T4 DNA 리가아제 5 U 및 10 ul 반응 부피 중 10X 리가아제 완충액 1 ul을 가하여 60 분동안 대기 온도에서 수행하였다. 마지막 DNA 서열 확인을 유도하는 그 다음 단계가 상기 설명되어진 것과 같이 수행되었다.

실험예 94

다양한 (GlyGlyGlySer)X 반복 동기를 가진 세번째 타입의 링커를 모듈방식으로 구성된 주형에서 서열 재배열된 flt3 수용체 아고니스트의 다른 세트로 삽입하였다. 이들 링커의 길이는; 6 AA 링커 (GlyGlyGlySerGlyGly SEQ ID NO:792), 7 AA 링커 (GlyGlyGlySerGlyGlyGly SEQ ID NO:793), 10 AA 링커 (GlyGlyGlySerGlyGlyGlySerGlyGly SEQ ID NO:794), 13 AA 링커 (GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly SEQ ID NO:795), 15 AA 링커 (GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGly SEQ ID NO:796); 및 21 AA 링커 (GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly SEQ ID NO:797) 아미노산 잔기. 각 유일한 길이의 BamHI-함유 링커에 의해 분리된 hflt3 리간드의 다이머로 이루어지는 이들 모듈방식의 주형은 다음과 같이 구성된다. 여섯개의 중간 PLASMID 주형, FL3N, FL7N, FL11N, FL3C, FL4C 및 FL10C는 pMON32322에 응용한 것과 유사한 사이클링 조건을 사용하여 짝지워진 프라이머와 주형으로서 pMON30238을 사용한 PCR에 의해서 구성되었다. 반응당, 각 프라이머 50 pmol을 pMON32322를 위해 설명한 것과 같이 결합시킨 반응물과 열-변성된 주형 100 ng에 가했다. 사이클 조건은 다음과 같다: 94℃에서 1분; 65℃에서 2 분, 그리고 72℃에서 2.5분의 7 사이클; 이어서 94℃에서 1분, 70℃에서 2분, 72℃에서 2.5 분의 10 사이클. 1회의 72℃에서 7분 연장으로 사이클 반응을 완성하였다. 각 중간체를 구성하기 위해 사용된 프라이머 쌍은 다음과 같다; N-term/FLN3 (FL3N); N-term/FLN7 (FL7N); N-term/FLN11 (FL11N); C term/FLC3 (FL3C); C-term/FLC3 (FL4C); C-term/FLC10 (FL10C). PCR 증폭생성물은 Wizard PCR Clean Up 키트로 정제하였고, 50 ul dH₂O에서 용출하였다.

첫번째 서브세트, FL3N, FL7N 및 FL11N을 위한 정제된 DNA를 앞서 설명한 것과 같이 NcoI/BamHI으로 절단하였고, 겔 정제하고, NcoI/BamHI/Sap-처리한 pSE420 벡터 DNA (Invitrogen)에 라이게이션시켰다. 두 번째 서브세트, FL3C, FL4C 및 FL10C의 중간 주형은 NcoI 대신에 HindIII를 사용하는 것을 제외하고 동일한 방법으로 구성하였다. 마지막 DNA 서열 확인을 유도하는 그 다음의 단계는 상기 설명한 것과 같이 실행하였다.

실시예 95

마지막 여섯개의 주형을 제조하기 위해 pSE420 내의 중간체 두 서브세트를 앞서 설명한 것과 같이 NcoI/BamHI (FL3N, FL7N, FL11N-서브세트 1) 또는 BamHI/HindIII (FL3C, FL4C 및 FL10C-서브세트 2)로 절단하였고, Geneclean II를 사용하여 겔 정제하였다. 각 서브세트로부터의 하나의 중간 암플리콘을 반응물 당 NcoI/HindIII/SAP-처리한 pMON3977으로 라이게이션시키고, 특정 링커 길이를 생성하기 위해 다음의 조합을 사용하여 앞서 설명한 것과 같이 DH5α 세포에서 형질전환시켰다: 6개의 AA 링커 (FL3N 및 FL3C), 7개의 AA 링커 (FL3N 및 FL4C), 10개의 AA 링커 (FL7N 및 FL3C), 13개의 AA 링커 (FL3N 및 FL10C), 15개의 AA 링커 (FL11N 및 FL4C), 그리고 21개의 AA 링커 (FL11N 및 FL10C). DNA는 상기 설명한 것과 같이 여섯 조합의 각각으로부터의 단일 콜로니로부터 50 ml 하룻밤 배양물로 제조하였고, NcoI/HindIII 제한 분석에 의해서 맞는 삽입 크기를 분석하고 주형으로서 사용하였다.

프라이머 쌍 39For/39Rev (39/40 절단점); 65For/65Rev (65/66 절단점) 및 89For/89Rev (89/90 절단점)을 각 프라이머 75 pmol을 사용한 것을 제외하고 pMON32322에서 설명한 것과 같이 각 주형의 PCR 증폭에 사용하였다. 증폭 조건은 다음과 같이 변형시켰다: 94℃에서 1분, 70℃에서 2 분, 72℃에서 2.5분℃의 6 사이클; 이어서 94℃에서 1분, 그리고 72℃에서 3 분의 9 사이클. 마지막 사이클 후, 72℃에서 6분간의 마지막 연장으로 생성물의 완전한 연장을 위한 충분한 시간을 가졌다.

샘플은 설명한 것처럼 Wizard PCR Clean Up 키트를 사용하여 정제하였고, 겹친 것은 NcoI/HindIII로 이중 절단하였다. 이들 증폭 생성물을 Wizard PCR Clean Up 키트를 사용하여 다시 정제하였다. 게다가, 39/40 절단점을 위한 모든 여섯개의 다른 링커 길이의 분자를 단일 단백질(pMON32365, pMON32366, pMON32367, pMON32368, pMON32369 및 32370)로서 NcoI/HindIII/SAP-처리한 pMON3977 내로 클로닝하였다. 마지막 DNA 서열 확인을 유도하는 그 다음의 단계를 상기 설명한 것과 같이 수행하였다.

실시예 96

본래의 flt3 리간드 또는 서열 재배열된 flt3 수용체 아고니스트, 실시예 91-93에 IgG2b 링커를 통하여 결합된 pMON13416 (WO 94/12638)로, IL-3 수용체 아고니스트로 구성되는 다기능 키메라 수용체 아고니스트 분자를 암호화하는 유전자를 구성하였다. 원하는 서열 재배열된 flt3 수용체 아고니스트 분자를 포함하는 삽입물을 NcoI/HindIII 제한 조각으로 모 플라스미드로부터 분리하였고 AflIII/Hind III/SAP로 절단된 pMON30304에 라이게이션하였다. 마지막 DNA 서열 확인을 유도하는 그 다음 단계를 상기 설명한 것과 같이 수행하였다.

IL-3 수용체 (pMON13416으로부터)와 서열 재배열된 flt3 수용체 아고니스트로 이루어지는 다기능 키메라 분자를 암호화하는 DNA 서열을 함유하는, 결과의 플라스미드는 표 9에 나타낸다.

결과의 플라스미드	hflt3 리간드 퍼뮤테인 전구체
pMON30247	pMON30237
pMON30248	pMON30238
pMON32332	pMON32321
pMON32333	pMON32320
pMON32334	pMON32325
pMON32335	pMON32324
pMON32336	pMON32323
pMON32337	pMON32328
pMON32338	pMON32327
pMON32339	pMON32326

실시예 97

본래의 flt3 리간드 또는 서열 재배열된 flt3 수용체 아고니스트, 실시예 91-93에 IgG2b 링커를 통하여 결합된 pMON13288 (WO 94/12638)로, IL-3 수용체 아고니스트로 구성되는 다기능 키메라 수용체 아고니스트 분자를 암호화하는 유전자를 구성하였다. 원하는 서열 재배열된 flt3 수용체 아고니스트 분자를 포함하는 삽입물을 NcoI/HindIII 제한 조각으로서 모 플라스미드로부터 분리하였고 AflIII/Hind III/SAP로 절단된 pMON30311에 라이게이션하였다. 마지막 DNA 서열 확인을 유도하는 그 다음 단계를 상기 설명한 것과 같이 수행하였다. IL-3 수용체 아고니스트(pMON13288로부터)와 서열 재배열된 flt3 수용체 아고니스트로 이루어지는 다기능 키메라 분자를 암호화하는 DNA 서열을 함유하는, 결과의 플라스미드는 표 10에 나타낸다.

결과의 플라스미드	Flt3 리간드 전구체
pMON32364	pMON30237
pMON32377	pMON30238
pMON32352	pMON32321
pMON32353	pMON32320
pMON32354	pMON32325
pMON32355	pMON32324
pMON32356	pMON32323
pMON32357	pMON32328
pMON32358	pMON32327
pMON32359	pMON32326
pMON32360	pMON32348
pMON32362	pMON32350
pMON32396	pMON32339

실시예 98

키메라 분자의 N-말단에 서열 재배열된 hflt3 수용체 아고니스트 성분을 가진 키메라 분자를 원래의 flt3 리간드 분자의 C 말단에 정지코돈을 인프레임 SnaBI 제한 부위로 대체하기 위해서 프라이머 쌍 N-term/134rev 및 N-term/139 rev와 주형으로서 pMON32360 및 pMON32362 플라스미드 DNA를 사용하여 PCR로 구성하였다. 반응 혼합물을 앞서 pMON32322에서 설명한 것처럼 만들었다. 사이클 조건은 다음과 같다: 94℃, 1분; 65℃에서 2 분 그리고 72℃에서 2 1/2분의 7 사이클과 10번의 추가 증폭 사이클을 어닐링 온도를 65℃에서 70℃로 올려 수행하였다. 샘플은 Wizard PCR 정제 키트와 프로토콜을 사용하여 정제하였고, 50 ul dH₂O에서 용출하였고, 각 샘플의 20 ul를 NcoI와 SnaBI로 절단하였다. 플라스미드, pMON26431, DNA를 NcoI와 SnaBI로 절단하였고, NcoI/SnaBI로 절단된 PCR 반응물과 라이게이션시켰다. 콤피턴트 DH5α세포의 형질전환과 마지막 DNA 서열 확인을 유도하는 그 다음 단계가 상기 설명한 것과 같이 수행되었다.

실시예 99

상기 설명한 것과 같이 10개와 15개 아미노산 링커 (GlyGlyGlySer)x를 증폭하기위해서 지시된 프라이머 28/29(27For/28Rev), 34/35(34For/34Rev), 62/63(62For/62Rev), 94/95(94For/94Rev) 및 98/99(98For/98Rev)를 사용하여 5개의 추가 hlt3 리간드 절단점을 제조하였다. 결과의 PCR 생성물은 앞서 설명한 것과 같이 NcoI/HindIII로 절단하였고, pMON30311로 라이게이션시킨 후, AflIII/HindIII/SAP로 결단하였다. 콤피턴트 DH5α세포의 형질전환과 마지막 DNA 서열 확인을 유도하는 그 다음 단계가 상기 설명한 것과 같이 수행되었다.

실시예 100

E. coli에서 서열 재배열된 hflt3 수용체 아고니스트의 증가된 발현을 위해서, 변성된 코돈을 암호화하는 N-말단 특정 프라이머를 E. coli 발현 벡터 pMON5723에서 원래의 hflt3 리간드의 1-134 및 1-139 형태 둘다를 재공학하는데 사용하였다. 프라이머 쌍 FH3AFor/SCF.rev (Ala2) 및 Flt23For/SCF(Gly2)를 원래의 flt3 리간드를 암호화 하는 서열의 N-말단 변성 혼합물을 PCR 증폭시키는 데 사용하였는데, 증폭 사이클 수를 95℃에서 1 분, 55℃에서 2분, 72℃에서 2 1/2분의 15 사이클로 감소시킨 것을 제외하고는 pMON23222에 설명된 것과 같은 반응 조건을 사용하였다. 암플리콘은 Wizard PCR Clean Up 키트 (Promega)를 사용하여 정제하였고, 50 ul dH₂O에서 용출하였다. NcoI/HindIII를 사용한 제한 절단과 이어서 Geneclean II를 사용한 겔 정제는 앞서 설명한 것과 같이 수행되었다. 삽입물을 NcoI/HindIII/SAP-처리한 겔 정제한 pMON5723 플라스미드 DNA에 라이게이션시키고, 콤피턴트 DH5α 세포로 앞서 설명한 것과 같이 형질 전환시켰다. 형질전환된 세포 분취량은 75 ug/ml 스펙티노마이신을 함유하는 LB 아가로스 배지 플레이트 상에 판상으로 깔고, 37℃에서 14-16 시간동안 배양한 후, 콜로니 수를 계산하였다. 콜로니를 확인한 후, 각 형질전환된 혼합물의 잔여물은 75 ug/ml 스펙티노마이신을 함유하는 2×5 ml LB 배지에서, 37℃에서 하룻밤동안 (14-16 시간)동안 배양하였다. Miniprep DNA를 추천되는 프로토콜에 따라 Wizard DNA 373A Miniprep 키트(Promega)를 사용하여 제조하였다. 정제된 Miniprep DNA를 50 ul dH₂O에서 용출하였고, 1-2 ul를 화학적으로 콤피턴트 MON207 세포를 형질전환하기 위해 사용하였다. 25와 200 ul의 분취량을 75 ug/ml 스펙티노마이신을 함유하는 LB 배지 플레이트 상에 판상으로 깔고, 37℃에서 12-15 시간동안 배양하였다. 각각 원래의 프라이머 쌍을 나타내는 40-50 잘 분리된 콜로니를 선택하고, LB/스펙티노아미신 마스터 플레이트 상에 스트리킹하고, 37℃에서 4-6 시간동안 추가 배양하였다.

개개의 서열 재배열된 hflt3 수용체 아고니스트 클론을 향상된 발현 수준을 선택하는 96 웰 마이크로타이터 포맷에서 E.coli 발현을 스크린하였다. 웰 당, 최소의 M9 배지( 1카사미노산를 포함하는) 100 ul를 단일 콜로니(40-50 분리물을 각 hflt3 PCR 프라이머 쌍을 위해 분석하였다) 당 접종하였고 37℃에서 3-4 시간동안(I=4) 200 rpm으로 배양하고, 1mg/mL의 새롭게 제조된 날리디식엑시드(0.1 N NaOH 중)를 5 ul/well으로 가함으로써 유도하였다. 37℃에서 4 시간동안 더 배양한 후(I=4), 약 5-10 ul 분취량을 각 웰에서 걷어내어, 굴절소체의 존재를 확인하기 위해 광학 현미경 검사로 분석하였고, 그 결과는 총세포수에 대하여 굴절소체를 함유하는 세포를 대략의 백분율로서 계산한다. 가장 높은 활성 수준을 가지는 클론을 다음과 같은 10 ml 벤치탑 규모 발현 연구를 위해 선택하였다. 5 mL의 하룻밤동안의 배양물을 37℃에서 75 ug/ml 스펙티노마이신의 존재 하에서 LB 배지에서 성장시켰다. 125 mL 진동 플라스크에서 새로 제조된 최소의 M9 (1 카사미노산를 가진) 10 ml에, 20 클렛 단위의 초기 리딩에 도달하기 위해 충분한 하룻밤 세포로 접종하였고, 그다음 밀도 ~110-150 클렛 단위에 도달할 때까지(I=0) 교반하면서 37℃에서 ~3-4 시간동안 배양하고 50 ul의 새롭게 제조된 날리디식엑시드 (0.1 N NaOH 중 10 mg/mL)를 가지고 유도하였다. 1 ml의 분취량을 제거하여 세포를 마이크로퓨즈에서 1분간 침전시켰다. 그 상층액을 흡출하여 제거하고, 그 펠릿을 SDS-PAGE 분석용으로 준비될 때까지 -20℃에서 저장하였다. 이 시간 점(I=4) 세포 밀도(클렛 단위로)를 측정한 후, 유도된 세포의 잔여물을 교반하면서 37℃에서 4 시간동안 더 배양하였다. 1 mL의 분취량을 상기 설명한 것과 같이 각 샘플에서 제거하고, 침전시킨 후, 저장하였다. 또 다른 5-10 ul의 분취량을 각 플라스크에서 제거하여 굴절소체가 존재하는 지를 광학 현미경으로 분석하였다. 침전된 샘플을 I=4 클렛 값에 해당하는 (1비-메캅토에탄올을 포함하는) 2X 로딩 완충액 1 부피 (ul 단위로)에서 재현탁시키고, 5분간 가열시킨후, 6-7 ul를 12 또는 14 Tris-Glycine SDS 폴리아크릴아미드 겔 (Novex) 상에 부하하였고, 90 볼트에서 90 분간 전기영동하였다. 제안된 프로토콜(Novex)에 따라서 겔을 고정시키고, 염색하고, 건조로 제조하였다. 클론은 I=0 샘플과 비교하여 예상되는 크기에 해당하는 단일의 유도된 단백질 밴드 (I=4)의 증가된 발현 수준을 기본으로한 정률 증가 발효를 위해 이 점에서 선택되었다.

Midiprep DNA는 또한 앞서 설명한 것과 같이 높은 수준의 유도된 단백질을 발현하는 선택된 클론으로부터 제조되었고 마지막 DNA 서열 확인을 유도하는 단계가 상기 설명한 것과 같이 정확하게 수행되었다. 이들 클론을 pMON32329, pMON32330, pMON32341 및 pMON32342로 명명하였다.

실시예 101

IL-3 수용체 아고니스트(pMON13288로부터)와 원래의 flt3 리간드로 이루어지는 다기능 수용체 아고니스트 키메라 분자의 세트를 E. coli에 발현시키기 위해 구성하였다. pMON32364 및 pMON32377로부터의 다기능 수용체 아고니스트 키메라 분자를 코드하는 유전자를 상기 설명한 것과 같이 NcoI/HindIII로 절단하여 모 벡터에서 떼어내 pMON5677 벡터에 라이게이션시키고, MON207 세포 내로 형질전환시킨 후, 단일 분리물을 골라낸다. 이들 구조물을 pMON32394(pMON32364으로부터 삽입물) 및 pMON32395(pMON32377로부터 삽입물)로 명명하였다.

실시예 102

잘려진 Flt3 수용체를 주형으로서 약 10 ng의 플라스미드 pMON27184를 가지고 50 pmol의 프라이머 FLTAFLS1 및 FLTR1N을 사용하여 1.4 Kb PCR 생성물로서 분리하였다. 이 프라이머는 추정상의 막통과 부위에 대해 바로 5'에 EcoRI 제한부위는 물론 성숙한 코딩 서열의 첫 Asn 코돈에 대해 바로 5'에 AflIII제한 부위을 생성하는 것으로 계획되었다. 이 반응물은 표준 반응 조건을 사용하여 AflIII 및 EcoRI로 절단하였고, NcoI/EcoRI로 절단한 플라스미드 pMON26458로 라이게이션시켰다. 이 플라스미드는 다음과 같은 DNA 서열을 포함한다: IL-3 신호 서열을 코드하는 5'-GGATCCACCATGAGCCGCCTGCCCGTCCTGCTCCTGCTCCAACTCCTGGTCCGCCCCGCCATGGCTAAAGCTT-3' SEQ ID NO:857. 이 서열은 5' 말단 상에 BamHI 제한 부위를 포함하고, BamHI 부위에 대해 3'에 신호서열의 첫 아미노산으로서 ATG 메티오닌을 포함한다. 이 신호서열은 PCR 반응에서 생성된 수용체의 AflIII 부위에 융합된 신호서열로부터 NcoI 부위를 융합함으로써 생성된 5' Met/Ala를 남기면서 세포에 의해 쪼개진다. IL-3 신호 서열과 함께 완전히 잘라진 형태의 수용체를 BamHI/EcoRI절단 (hIL3L/hFflt3R)으로 벡터 밖으로 다시 잘라낼 수 있다.

pMON30298 (hG-CSFR)의 촉매 도메인은 다음과 같이 PCR을 통해 막통과/세포질 경계에서 인프레임 EcoRI 제한 부위를 만들기 위해 재공학되었다. 열 변성된 pMON30298 0.5 ug에, 각 프라이머 HGCFfor 및 HGCFrev 100 pmole, 5X 완충액 J 10 ul, Taq 폴리머라제 5U, dH₂O를 설명한 것처럼 45 ul의 마지막 부피가 되도록 가했다. PCR 증폭은 다음과 같이 수행되었다: 6 사이클 (94℃의 1분, 64℃에서 2 분, 70℃에서 3분), 이어서 9 사이클 (94℃에서 1분, 70℃에서 4 분). 70℃에서 7분의 마지막 1분 연장을 수행하였다. 각 PCR 반응물의 10 ul는 앞서 설명한 것처럼 Geneclean II를 사용하여 겔 정제하였고, 10 ul dH₂O에서 용출하였다. 샘플은 37℃에서 90 분간 20 ul 반응물 중 EcoRI 및 HindIII 각 10 U를 가지고 절단하였다. 샘플을 상기 설명한 것과 같이 다시 겔정제(Geneclean II)하였고, 10 ul dH₂O에서 용출하였다. 삽입물 2 ul을 앞서 설명한 것처럼 10 ul 반응물 중 NcoI/HindIII/phosphatased pSE420 50 ng에 라이게이션시켰다. 콤피턴트 DH5α 세포의 형질전환과 마지막 DNA 서열 확인을 유도하는 그 다음 단계가 상기 설명한 것과 같이 정확하게 수행되었다. 그 다음 선택된 클론은 맞는 G-CSFR 촉매 도메인 DNA 서열의 확인은 물론 인 플레임 E. coRI 부위의 존재를 확인하기 위해 서열화되었다. 예상되는 서열을 포함하는 클론을 앞서 설명한 것과 같이 EcoRI/HindIII로 절단하였고 겔 정제하였다. hG-SCFR (EcoRI/HindIII) 및 hIL3L/hFlt3R (BamHI/EcoRI) 조각의 정제된 삽입물을 BamHI/HindIII/phosphatased pcDNA 3.1 (-) 벡터 (Invitrogen)에 라이게이션시켰다. 콤피턴트 DH5α 세포의 형질전환과 마지막 DNA 서열 확인을 유도하는 그 다음 단계가 상기 설명한 것과 같이 수행되었다.

실시예 103

서열 재배열된 Flt3 리간드를 코드하는 추가의 유전자를 앞서 설명한 다이머 주형 중간체를 사용하여 구성하였다. 15개의 아미노산 링커 (GlyGlyGlySer)₃GlyGlyGly SEQ ID NO:795를 가지는 서열 재배열된 flt3 수용체 아고니스트를 위해서, 다이머 중간체 Flt4C.seq 및 Flt11N.seq 가 주형으로 사용되었다. Flt33 리간드 아미노산 잔기 28/29, 34/35, 62/63, 94/95 및 98/99에 상응하는 절단점을 PCR Optimizer 키트 (Invitrogen) 및 다음의 프라이머 쌍을 사용한 PCR에 기초를 둔 접근법을 사용하여 구성하였다; 실시예 94에 설명한 것과 같이 FL29For/FL29Rev, FL35For/FL35Rev, FL63For/FL63Rev, FL95For/FL95Rev, FL99For/FL99Rev. 증폭 조건은 다음과 같다: 94℃의 1분, 62℃에서 2 분, 70℃에서 2.5분의 7 사이클; 94℃에서 1분, 68℃에서 2 분, 70℃에서 2.5 분의 12 사이클; 이어서 72℃에서 7분의 마지막 사이클. 예상되는 삽입 크기에 상응하는 PCR 생성물을 NcoI와 HindIII로 절단하고 제조자의 제안된 프로토콜에 따라서 Geneclean II(Bio 101)를 사용하여 앞서 설명한 것과 같이 겔 정제하였다. 샘플은 dH₂O로 10 ul의 마지막 부피를 맞춰 재현탁하였다. 삽입물은 포유동물 발현 벡터 pMON3934 (NcoI/HindIII/SAP 처리한) 내로 단일 유전자로서 클론되었고, 각각 pMON35712, pMON35713, pMON35714, pMON35715, pMON323235716, pMON35717 및 pMON35718로 명명되었다.

여기서 "IL-3 수용체 아고니스트 I"으로 명명되는 pMON13288 (WO 94/12638)에 의해 암호화된 IL-3 수용체 아고니스트로 이루어지는 키메라 단백질을 암호화하는 유전자와 서열 재배열된 Flt3 리간드를 28/29, 34/35, 62/63, 94/95 및 98/99 절단점 프라이머 쌍의 정제된, 제한-절단 PCR 생성물을 AflIII/HindIII/SAP-처리한 pMON30311 내로 클로닝함으로써 준비되었다. 그 결과의 플라스미드는 pMON32398, pMON35700, pMON35702, pMON35704, pMON35706로 명명되었다. 게다가 같은 프라이머 쌍이 이들 IL-3 수용체 아고니스트 I/Flt3L 키메라 단백질의 형태, 10 개의 아미노산 링커 (GlyGlyGlySer)₂GlyGly SEQ ID NO;793을 구성하기 위하여, 다이머 주형 중간체 Flt7N.seq 및 Flt3C.seq와 결합하여 사용되었다: 각각 pMON32397, pMON32399, pMON35701, pMON35703, 및 pMON35705.

실시예 104

21 개의 아미노산 잔기 링커 (GlyGlyGlySer)₅Gly SEQ ID NO:796을 포함하는 IL-3 수용체 아고니스트 I/Flt3L 키메라 단백질을 암호화하는 유전자를 다이머 주형 중간체 Flt11N.seq 및 Flt10C.seq와 다음의 프라이머 쌍(Flt36/36Rev, Flt37/37Rev, Flt38/38Rev, Flt39/39Rev, Flt41/41Rev, Flt42/42Rev 및 Flt43/43Rev)를 사용하여 유사한 PCR 접근법을 이용하여 구성하였다. 이들 프라이머 쌍은 다음의 Flt3 리간드 절단점 35/36; 36/37; 37/38; 38/39; 40/41; 41/42; 및 42/43 (39/40 절단점은 앞서 pMON32376으로 구성되었다)에 해당하고, 다음의 사이클 조건을 사용하여 PCR 증폭에 사용되었다: Invitrogen PCR Optimizer 키트 (완충액 B)를 사용하여 94℃의 1분, 66℃에서 2 분, 70℃에서 2.5분의 7 사이클; 94℃에서 1분, 70℃에서 4 분의 15 사이클, 이어서 72℃에서 7분의 마지막 사이클. DNA 서열 확인에 따라서 이들 구성물은 각각 pMON35733, pMON35734, pMON35735, pMON35736, 및 pMON35738, pMON35739, pMON35740, pMON35741, pMON35742, 및 pMON35743으로 명명된다. PCR 결합 오차는 서열 재배열된 Flt3 키메라 파트너의 두개의 단일 아미노산 치환 (pMON35741, 35/36 절단점; 및 pMON35743, 42/43 절단점)과 Flt 일부 중 Q¹³³를 R¹³³로 그리고 Q¹⁰⁰를 R¹⁰⁰로 그리고 L¹¹²를 P¹¹²로의 두 개의 아미노산 치환을 포함하는 하나의 구성물 (pMON35742, 38/39 절단점)을 초래하였고 이 시리즈의 일부로서 구성되고 시험되었다.

앞서 설명한 Flt3 리간드 아미노산 잔기 28/29, 34/35, 62/63, 65/66, 89/90, 94/95 및 98/99에 상응하는 대체의 Flt3 절단점이 있는 추가의 Flt3L/IL-3 수용체 아고니스트 I 키메라 단백질을 또한 15개의 아미노산 링커 (GlyGlyGlySer)₃GlyGlyGly 주형 Flt4C 및 Flt11N을 가지고 구성하였다. 서열 재배열된 Flt3 부분의 C-말단을 암호화하는 역 프라이머를 HindIII 제한 부위를 SnaBI 인식 서열로 대체함으로써 변형시키는 것을 제외하고, PCR 반응 혼합물은 실시예 103에서 설명된 것과 유사하였다. PCR 증폭 사이클의 파라미터는 다음과 같다: 94℃의 1분, 66℃에서 2 분, 70℃에서 2.5분의 7 사이클; 94℃에서 1분, 70℃에서 4 분의 14 사이클; 이어서 72℃에서 7분의 마지막 사이클. PCR 클린업, 제한 절단 및 정제가 앞서 설명된 것과 같이 수행되었다. 삽입물을 다음과 같이 NcoI/SnaBI/SAP-처리한 pMON26431 (IgG2b 링커/IL-3 수용체 아고니스트 I 일부를 포함하는 BHK 발현벡터)에 라이게이션하였다; 50ng 처리한 벡터, 삽입물 (10:1 삽입물:벡터), T4 DNA 리가아제 (Gibro BRL) 1 unit 및 10 ul 반응 부피 중 1ul 10X 리가아제 완충액. 라이게이션물을 대기 온도에서 1시간동안 배양시켰고 그 다음 각 라이게이션물 중 2 ul를 제거하여 제조자가 제안한 프로토콜에 따라서 화학적으로 콤피턴트 DH10B (다른 방법으로, DH5α)세포 (Gibco BRL) 100 ul를 형질전환하기 위해 사용하였다. 각 형질전환 혼합물의 1/15 와 1/25 부피를 적당한 항생제 마커가 첨가된 LB 한천 플레이트 상에 판상으로 깔고, 37℃에서 하룻밤동안(14-16 시간) 배양하였다. 분리된 콜로니를 골라내고, 앞서 설명한 것처럼 Qiagen midiprep 프로토콜을 사용하여 DNA를 제조하였다.

선택된 콜로니의 서열 분석으로 28/29 절단점 (pMON35719), 34/35 절단점 (pMON35720), 62/63 절단점 (pMON35721), 65/66 절단점 (pMON35722), 89/90 절단점 (pMON35723) 및 98/99 절단점 (pMON35725)을 확인하였다. pMON35726은 94/95 절단점을 위한 단일 아미노산 치환(Leu94를 Phe94로)을 포함한다. 10, 15, 및 21 AA의 다양한 길이의 아미노산 링커와 39/40의 Flt3L 절단점을 가진 Flt3L/IL-3 수용체 아고니스트 I 키메라 구조물은 pMON35707, pMON35708, pMON35709, pMON35710, 및 pMON35711로 나타낸다. 이들 구조물은 다음의 주형 중 하나의 PCR 증폭에 의해 생성되었다; pMON32373, pMON32375 또는 pMON32376, 및 Flt3L-특정 프라이머 쌍 39N TERM-1/SNABIC TERM. 표준 PCR 반응 혼합물이 앞서 설명한 것처럼 만들어졌고, 다음의 파라미터를 사용하여 DNA 생성물을 증폭시켰다: 94℃의 1분, 62℃에서 2 분, 70℃에서 2.5분의 7 사이클; 94℃에서 1분, 68℃에서 2분 및 70℃에서 2.5분의 12 사이클; 이어서 72℃에서 7분의 마지막 사이클. 예상되는 삽입 크기에 해당되는 PCR 생성물은 NcoI와 SnaBI로 절단하여 완성하고, 겔 정제하였고 앞서 설명한 것처럼 Flt3L/IgG2b/IL-3 수용체 아고니스트 I 키메라 단백질로서 포유동물의 발현 벡터 pMON26431 (NcoI/SnaBI/SAP 처리한) 내로 클로닝하였다. 이들 두 개의 구조물은 F⁹⁶을 L⁹⁶로, 그리고 E⁵⁸을 G⁵⁸로(pMON35710 및 pMON35711) 단일 아미노산의 치환을 초래한 서열 재배열된 Flt3 키메라 파트너에서의 PCR 결합 오차를 포함한다.

실시예 105

다른 일련의 키메라 단백질, 앞서 설명한 Flt3 리간드 아미노산 잔기 35/36, 36/37, 38/39, 40/41, 41/42, 42/43 및 65/66에 상응하는 절단점을 가진 서열 재배열된 Flt3L/IL-3 수용체 아고니스트 I과 21 아미노산 링커를 또한 주형으로서 선택된 IL-3 수용체 아고니스트 I/서열 재배열된 Flt3L 구조물을 사용하여 구성하였다(아래의 표 11을 보라). 한가지 예외는 15개의 아미노산 링커 주형 (pMON35715)을 65/66 절단점, pMON35771을 구성하기 위해 사용한 것이다.

Flt3L/IL-3 수용체 아고니스트 I IL-3 수용체 아고니스트 I/Flt3L

구조물	주형	Flt3L 절단점	프라이머 쌍
pMON35744	pMON35733	35/36	Flt36/36Rev'
pMON35745	pMON35734	36/37	Flt37/37Rev'
pMON35746	pMON35735	37/38	Flt38/38Rev'
pMON35747	pMON35736	38/39	Flt39/39Rev'
pMON35748	pMON35738	40/41	Flt41/41Rev'
pMON35749	pMON35739	41/42	Flt42/42Rev'
pMON35750	pMON35740	42/43	Flt43/43Rev'
pMON35769	pMON35743	42/43	Flt43/43Rev'
pMON35771	pMON35715	65/66	65For/66SnaBI

pMON35719-35725를 구성하기 위해 사용한 것과 같은 동일한 제한 부위를 암호화하는 프라이머 쌍을 사용하였다. 역 프라이머 36Rev', 37Rev', 38Rev', 39Rev', 41Rev', 42Rev' 및 43Rev'을 인 프레임 SnaBI 부위를 만들기 위해 사용하였다. 동일한 전방의 프라이머 Flt36, Flt37, Flt38, Flt39, Flt41, Flt42 및 Flt43이 사용되었다. PCR 반응 생성물은 앞서 설명된 것과 동일하다. 그러나 pMON35771를 제외하고 증폭 조건은 다음과 같이 변형되었다: 94℃의 1분, 68℃에서 2 분 및 70℃에서 2.5분의 18 사이클; 이어서 70℃에서 7분의 1회의 연장 사이클. pMON35771을 위한 증폭조건은 다음과 같다: 94℃의 1분, 66℃에서 2 분 및 70℃에서 2.5분의 6 사이클; 94℃의 1분, 70℃에서 4 분의 15 사이클; 이어서 72℃에서 7분의 마지막 사이클. Flt3-특정 PCR 증폭 생성물을 실시예 104에서 설명한 것과 같이 제한 절단하고, 정제하고 pMON26431 (IgG2b 링커/IL-3 수용체 아고니스트 I 일부를 포함하는 BHK 발현벡터) 내로 클론닝하였다.

하나의 변종, pMON32179를 PCR 프라이머 쌍 Flt40/34Rev와 다이머 주형 중간체 Flt11N.seq 및 Flt10C.seq를 사용하여 34/40 절단점으로 구성하였다. PCR 증폭 조건과 그다음의 클로닝은 클론 pMON35771에 사용되었던 것과 동일하다.

교체 링커 길이와 조성의 효과를 시험하기 위하여 세 개의 추가 Flt3L/IL-3 수용체 아고니스트 I 키메라 (38/39 절단점)을 계획하고 구성하였다. 주형으로서 pMON35709를 사용하여, GlySer 링커 길이를 프라이머 쌍 BamFor1/38Rev (반응생성물은 PCR A로 언급된다)와 Flt38/BamRev1 (반응 생성물은 PCR B로 언급된다)를 사용하여 동기 (GlyGlyGlySer)₇Gly를 가진 29 개의 아미노산을 포함하도록 연장하였다. 증폭 조건은 다음과 같다: 94℃의 1분, 66℃에서 2 분 및 70℃에서 2.5분의 6 사이클; 94℃의 1분, 70℃에서 4분의 15 사이클; 이어서 72℃에서 7분의 마지막 사이클. 그 결과의 PCR 생성물은 앞서 설명한 것과 같이 Promega PCR Clean up 키트를 사용하여 클린업하였고, NcoI/BamHI(PCR A) 또는 BamHI/SnaBI (PCR B)로 절단하고, 겔 정제한 후, pMON26431 (IgG2b 링커/IL-3 수용체 아고니스트 I 부분를 포함하는 BHK 발현벡터)에 라이게이션하였다. 그 결과의 구조물을 서열 확인하였고, pMON35774로 명명하였다. 비교하면, pMON35775 및 35776은 GlySer 링커가 단일의 아미노산 치환을 포함하는 원래의 Flt3L 아미노산 잔기 140-154 (pMON35775) 또는 140-160 (pMON35776)에 의하여 대체되었다는 점에서 다르다. PCR 반응 조건은 다음의 프라이머 쌍이 사용된 것을 제외하고 pMON35774에서 설명되었던 것과 동일하다: 38For/Navfor 및 38Rev/NavRevS (pMON35775); 및 38For/Navfor 및 38Rev/NavRevL (pMON35776). BamHI 대신 KasI를 사용했고, 달리 이들 PCR 증폭 생성물의 클로닝 단계는 pMON35774에 적용되었던 것과 동일하였다. pMON35775 및 365776을 위한 복합 분리물에서 PCR 유도된 오차를 서열 분석으로 밝혀냈다. 마지막의 맞는 서열을 얻기 위해서, 선택된 서브클론을 NarI/SnaBI 및 NcoI/NarI로 다시 절단하고, 원하는 구조물을 다시 클로닝하기 위해 이들 겔 정제된 조각을 사용하는 것이 필수적이었다.

몇가지 Flt3L 다이머 키메라 분자를 또한 BHK 통과물로서 시험하기 위해 구성되었다. IgG2b 링커에 의해 연결된 두 개의 원래 Flt3L 분자로 구성된 pMON32173을 다음과 같이 두 개의 이미 존재하는 분자로부터 조립하였다: pMON32393으로부터의 NcoI/SnaBI Flt3L-함유 삽입물을, IL-3 수용체 아고니스트 I 키메라 파트너가 방출된, 겔 정제된 NcoI/SnaBI 절단, pMON32393에 라이게이션시켰다.

유사하게, pMON35727 (39/40 절단점, 15 아미노산 링커)를 절단된 IL-3 수용체 아고니스트 I 키메라 파트너를 가진 겔 정제된 pMON32375에 pMON35708로부터의 Flt3L 삽입물을 사용하여 조립하였다. 세번째 Flt3L 다이머, pMON32168, (39/40 절단점, 21 아미노산 링커)를 다음과 같이 조립하였다: pMON32165(pMON32163로부터의 NcoI/BamHI 조각물과 pMON35709의 BamHI/HindIII 조각물을 NcoI/HindIII-절단된 pMON5723에 서브클로닝하여 조립한 pMON35709의 E. coli 동등물)로부터의 NcoI/SnaBI 삽입물. pMON32165로부터의 NcoI/SnaBI 삽입물(Flt3L 1-139 (39/40)L21)과 pMON32376으로부터의 SnaBI/HindIII 삽입물 (IgG2b/Flt3L 1-139 (39/40)L21)을 E. coli 생산 벡터 pMON5723에 서브클로닝하여 pMON32167을 만들었다. pMON32167로부터의 NcoI/HindIII 삽입물을 그다음 pMON30304에 서브클로닝하였고, pMON32168로 명명하였다.

실시예 106

각 두개의 Flt3L 일부와 IL-3 수용체 아고니스트 I 또는 IL-3 수용체 아고니스트 II (여기서 "IL-3 수용체 아고니스트 II"로서 불리어지는 pMON13416 (WO 94/12638)에 의해 암호화된 IL-3 수용체 아고니스트)의 단일 복제본을 구성하는 일련의 트라이머 분자를 또한 제한 절단, 겔 정제 조각물을 사용하여 이미 존재하는 분자로부터 구성하였다. pMON35728은 pMON32375으로부터의 NcoI/EcoRI (Flt3L/IgG2b/IL-3 수용체 아고니스트 I) 삽입물과 pMON35708으로부터의 EcoRI/HindIII (IL-3 수용체 아고니스트 I/IgG2b/Flt3L) 삽입물을 사용하여 조립하였다. 두 조각을 그 다음 NcoI/HindIII/SAP-처리한 포유동물의 발현 벡터 pMON3934에 라이게이션시키고, 앞서 설명한 것과 같이 서브클로닝하였다. pMON32205 (IL-3 수용체 아고니스트 II/IgG2B/Flt3L 1-139/IgG2B/Flt3L 1-139)를 pMON32173의 NcoI/HindIII 조각물을 AflIII/HindIII 위치에 라이게이션시켜 조립하였다. 유사한 접근법이 pMON32206(IL-3 수용체 아고니스트 II/IgG2b/Flt3L (39/40)L21/IgG2b/Flt3L (39/40)L21)을 구성하기 위해 사용되었다. pMON32167의 NcoI/HindIII 조각물은 겔이었고 AflIII/HindIII-절단된 pMON30304(이것은 IL-3 수용체 아고니스트 II/IgG2b-일부를 포함한다)에 서브클로닝하였다. 이 플라스미드 pMON32207 (Flt3L (39/40)L21/IgG2b/Flt3L (39/40)L21)G-CSF)를 pMON32170의 겔정제된 NcoI/HindIII 삽입물을 중간 pMON32198 (AflIII/HindIII)에 서브클로닝하여 조립하였다.

pMON32208 (Flt3L 1-139/IgG2b/G-CSF/IgG2b/Flt3L1-139)은 pMON30320(IgG2b/G-CSF로서)의 겔정제된 SnaBI 삽입물을 SnaBI-절단된/SAP-처리한 pMON32173에 서브클로닝하여 조립하였다. pMON32204는 pMON32173의 NcoI/HindIII 삽입물을 AflIII/HindIII-절단된 pMON30309(이것은 G-CSF/IgG2b를 포함한다)에 서브클로닝하여 조립하였다. pMON32195 (Flt3L 1-139(39/40)L21/IgG2b/G-CSF/Flt3L 1-139(39/40)L21)는 pMON32190의 NcoI/SacI 삽입물과 pMON32171의 SacI/HindIII 조각을 NcoI/HindIII-절단된 pMON30304에 서브클로닝하여 구성되었다. pMON32196 (G-CSF/IgG2b/Flt3L 1-139 (39/40)L21/IgG2b/Flt3L 1-139)은 pMON30309(G-CSF/IgG2b로서)의 NcoI/AflIII 조각을 NcoI/SAP-처리한 pMON32168 (Flt3L 1-139 (39/40)L21/IgG2b/Flt3L 1-139)에 서브클로닝하고 DNA 서열과 제한 분석에 의해서 배향을 확인하여 조립하였다. pMON32197 (G-CSF/IgG2b/Flt3L 1-139(39/40)L21/IgG2b/Flt3L 1-139(39/40)L21)은 pMON32167(Flt3L 1-139 (39/40)L21/IgG2b/Flt3L 1-139 (39/40)L21)의 NcoI/HindIII 삽입물을 pMON30309(G-CSF/IgG2b)의 AflIII/HindIII 위치에 서브클로닝하여 구성되었다.

실시예 108

분자를 포함하는 일련의 Flt3L은 IL-3 수용체 아고니스트 I 또는 IL-3 수용체 아고니스트 II를 키메라 파트너로서 G-CSF로 대체하여 BHK 통과물로서 구성하였다. BHK 벡터 pMON3934를 사용하여 일시적으로 발현되어 제조된 키메라 단백질을 위해, G-CSF 일부는 위치 17에서 Ser 또는 Cys을 암호화할 수 있다. E. coli 발현 또는 포유동물의 발현계에서 비일시적으로 발현시키는 데 사용되는 분자를 위해, G-CSF 파트머의 위치 17을 배타적으로 Ser으로 암호화하였다. 원래의 Flt3L과 G-CSF의 키메라는 두 배향에서 BHK 구조물로서 제조되었다: G-CSF/IgG2b/Flt3L (pMON30329) 및 Flt3L/IgG2b/G-CSF (pMON32175). pMON30329는 pMON30238으로부터의 Flt3L 1-139 삽입물 (NcoI/HindIII 절단물로서)을 AflIII/HindIII로 절단한 pMON30309 (이것은 G-CSF/IgG2b를 포함한다)에 서브클로닝하여 제조한 반면, pMON32175는 pMON32393의 겔-정제된 NcoI/SnaBI 삽입물을 NcoI/SnaBI-절단된 pMON26420(이것은 IgG2b/G-CSF 유전자를 포함한다)에 사용하여 구성되었다. 세번째 원래의 G-CSF/Flt3L 키메라 분자, pMON32191은 IgG2b 키메라 링커 대신 GlySer 링커를 가지고, E. coli발현을 위해 계획되었다는 점에서 pMON32175와 차이가 있다. pMON32191은 동일한 겔-정제된 pMON32393의 NcoI/SnaBI 삽입물을 NcoI/SnaBI-절단된 pMON31123 (이것은 GlySer/G-CSF 유전자를 포함한다)에 사용하여 조립하였다. BHK 동등물, pMON35767은 pMON32191의 겔-정제된 NcoI/HindIII 키메라 유전자를 BHK 벡터 pMON3934로 서브클로닝하여 조립하였다.

실시예 109

두개의 일련의 서열 재배열된 Flt3L 키메라는 IL-3 수용체 아고니스트 I 성분을 G-CSF로 대체하여 구성되었다. 배향 G-CSF/IgG2B 서열 재배열된 Flt3L를 가진 첫번째 세트를 다음과 같이 필수적으로 조립하였다: 상기 설명한 것과 같이 pMON30329 (G-CSF/IgG2B/Flt3L 1-139)를 SnaBI/HindIII로 절단하고, 벡터-함유 G-CSF 일부를 겔 정제하였다. 그 다음 아래 표12에 보여지는 적당한 IL-3 수용체 아고니스트 I/Flt3L 구조물로부터의 SnaBI/HindIII-절단된 삽입물을 pMON30329 (SnaBI/HindIII)에 서브클로닝하였다.

G-CSF/IgG2b/Flt3L 구조물과 이들의 IL-3 수용체 아고니스트 I 유사체

Flt3L 절단점	pMON(G-CSF)	pMON(IL-3 수용체 아고니스트 I)
35/36L21	pMON32188	pMON35733
89/90L21	pMON32273	pMON32389
37/38L21	pMON35795	pMON35735
38/39L21	pMON35796	pMON35736
40/41L21	pMON35797	pMON35738
41/42L21	pMON35798	pMON35739
42/43L21	pMON35799	pMON35740

pMON32169 (G-CSF/IgG2b/Flt3L 1-139 (39/40)L21)는 AflIII/HindIII-절단된 pMON30309로 서브클로닝된 pMON32370의 BamHI/HindIII 삽입물과 pMON32163의 NcoI/BamHI 삽입물을 사용하여 조립하였다. 이 일련에서의 세 분자는 어떤 직접적인 IL-3 수용체 아고니스트 I의 대응물을 가지고 있지 않다. 첫번째, pMON39914는 AflIII/HindIII로 절단된 BHK 발현 벡터 pMON30309 (이것은 G-CSF/IgG2b를 포함한다)와 pMON32243으로부터의 Flt3 1-139 (39/40)L29 삽입물(NcoI/HindIII로서)을 사용하여 만들었다. pMON39915를 위해, pMON32242로부터의 Flt3L 1-154 (39/40) 유전자 (NcoI/HindIII 삽입물로서)는 어버이 벡터 pMON30309로 서브클로닝되었다. pMON39916은 pMON32252로부터의 Flt3L 1-160 (39.40) 삽입물을 사용한 것을 제외하고, 정확하게 pMON39915에서처럼 만들었다. pMONs 32242, 32243 및 32252는 키메라가 아닌, 서열 재배열된 Flt3L 유전자 (NcoI/HindIII로서)를 포함하는 E. coli 발현 구조물이다. 마지막으로 pMON35799로부터의 삽입물을 E. coli 발현을 위해 pMON5723 (NcoI/HindIII 조각으로서)로 서브클로닝하였다. 이 E. coli 생성 플라스미드는 pMON39904로 명명되었다.

실시예 110

Flt3L/IgG2b/G-CSF 배향을 가진 일련의 G-CSF 키메라 다수는 또한 아래의 표 13에 나타낸 것으로 이들의 IL-3 수용체 아고니스트 I 유사체에서 구성되었다.

Flt3L/IgG2b/G-CSF 구조물과 이들의 IL-3 수용체 아고니스트 I 유사체

Flt3L 절단점	pMON(G-CSF)	pMON(IL-3 수용체 아고니스트 I)
39/40L10	pMON35751	pMON35707
39/40L15	pMON35752	pMON35708
39/40L21	pMON35753	pMON35709
89/90L15	pMON35754	pMON35723
35/36L21	pMON35755	pMON35744
36/37L21	pMON35756	pMON35745
37/38L21	pMON35757	pMON35746
34/35L15	pMON35759	pMON35720
65/66L15	pMON35760	pMON35722
98/99L15	pMON35765	pMON35725

이들 구조물은 상기 표에서의 Flt3L/IL-3 수용체 아고니스트 I 키메라 단백질로부터의 특정 NcoI/SnaBI-절단된 서열 재배열된 Flt3L 삽입물과 NcoI/SnaBI-절단된 pMON36113 (IgG2b/G-CSF 유전자를 함유하는 BHK 벡터)를 사용하여 조립하였다. 이 결과의 플라스미드는 pMON32170, pMON32871, pMON32271, pMON32172, pMON32174, pMON35751, pMON35752, pMON35753, pMON35754, pMON35755, pMON35756, pMON35757, pMON35758, pMON35759, pMON35760, pMON35761, pMON35762, pMON35763, pMON35764, pMON35765, pMON35766, pMON35767, pMON35768, pMON35770, pMON35772, pMON35773, pMON35777, pMON35778, pMON35779, pMON35780, pMON35782 및 pMON39908로 명명되었다.

pMON35777 및 pMON35778은 PCR로 구성하였고 IgG2b/G-CSF 유전자를 함유하는 모 벡터로서 NcoI/SnaBI-절단된 pMON35751을 사용한 것을 제외하고, pMON35775 및 pMON35776에서 설명된 것과 같이 동일한 NcoI/NarI 및 NarI/SnaBI 삽입물에서 조립하였다. pMON35778의 39/40 절단점 동등물을 구성하기 위하여, 프라이머 쌍 Flt40/SnaBI C-말단을 주형 pMON35778을 다시 증폭시키는 데 사용하였다. 증폭조건은 초기 T_anneal를 66℃에서 55℃로 낮춘 것을 제외하고 이전 pMON35771에서 설명되었던 것과 같이 수행하였다. 그 결과의 구조물은 pMON35782 (Flt3 1-160 (39/40)/IgG2b/G-CSF)로 명명되었다.

pMON32170 (Flt3L 1-139(39/40)L21/IgG2b/G-CSF)는 NcoI/SnaBI-절단된 pMON26430(이것은 IgG2B/G-CSF를 포함한다)로 라이게이션된 pMON32165로부터의 NcoI/SnaBI 삽입물을 사용하여 조립하였다. pMON35764 (Flt3L (38/39)L21/IgG2b/G-CSF)는 다음과 같이 클로닝되었다: 서열 재배열된 Flt3L 삽입물은 주형으로서 pMON35736과 프라이머 쌍 Flt39/39Rev를 사용하여 PCR 증폭시켰다. 증폭조건은 초기 T_anneal를 66℃에서 56℃로 낮춘 것을 제외하고 pMON35771에 적용되었던 것에 동일하게 수행하였다. NcoI/SnaBI 절단된 PCR 암플리콘은 IgG2b/G-CSF 유전자를 포함하는 NcoI/SnaBI-절단된 pMON35754로 서브클로닝되었다. pMON35768 (Flt3L (38/39)L21/IgG2b/G-CSF)는 Flt3 키메라 파트너의 잔기 15 (Ser이 Phe로)에서 돌연변이를 가진다.

pMON35762 (Flt3 주형 pMON35739), pMON35763 (Flt3 주형 35738), pMON365758 (Flt3 주형 35740), pMON35770 (Flt3L 주형으로서 pMON35743)이 pMON35764에서 설명된 것과 똑같이 구성되었다. pMON35760 중 서열 재배열된 Flt3 유전자의 S¹²⁵가 F¹²⁵로 된 돌연변이, pMON35772를 Flt3L 주형으로서 pMON35715와 프라이머 쌍 65For/65SnaBI를 사용하여 클로닝하였다. PCR 사이클 조건은 앞서 설명한 pMON35733, pMON35734, pMON35735 및 pMON35736으로부터의 Flt3 유전자를 증폭시키는 데 사용한 것과 동일했다. pMON35761은 pMON35758에서 서열 재배열된 Flt3L 유전자의 Q¹³³가 R¹³³으로된 돌연변이이다. pMON35773 (Flt3L 1-139 (38/39)L29/IgG2B/G-CSF)는 어버이 벡터로서 IgG2b/G-CSF 유전자를 포함하는 pMON26430 (NcoI/SnaBI/SAP-처리된)을 사용한 것을 제외하고, 앞서 pMON35774에 설명되었던 것과 같이 클로닝되었다.

39/40 절단점 동등물, pMON35773을 구성하기 위하여, pMON35773이 프라이머 쌍 Flt40/SnaBI C-말단과 함께 PCR 증폭 반응에서 주형으로 사용되었다. 증폭은 앞서 pMON35771에서 설명되었던 것과 똑같이 수행되었다. NcoI/SnaBI-절단된 증폭 생성물은 pMON26430 (NcoI/SnaBI/SAP-처리된)로 서브클로닝되었고, pMON35779 (Flt3L 1-139 (39/40)L29/IgG2B/G-CSF)로 결과되었다. pMON35780은 pMON35779의 변종이고 서열 재배열된 Flt3 키메라 파트너에서 단일 아미노산 돌연변이 (L⁶⁰이 P⁶⁰으로)를 암호화한다. pMON32190 (Flt3L 1-139 (39/40)L21/GS/G-CSF)는 pMON32170의 IgG2b 링커를 대체한 대안의 GlySer 키메라 링커를 포함한다. pMON32165로부터의 NcoI/SnaBI 조각 Flt3L 유전자 (E. coli 발현 벡터 pMON5723 중 Flt3L 1-139 (39/40)L21/IgG2b/IL-3 수용체 아고니스트 I)는 NcoI/SnaBI-절단된 pMON31123에 서브클로닝되었다. BHK 발현 동등물, pMON35766은 NcoI/HindIII 조각으로서 완전한 Flt3L/GlySer/G-CSF 키메라 삽입물을 pMON3934로 서브클로닝하여 구성되었다.

pMON39908은 Flt3L 아미노산 잔기 133-160이 Flt3L의 대체의 접착변종 (Genbank 취득 번호 HSU29874)과 일치하는 아미노산 잔기, VETVFHRVSQDGLDLLTS SEQ ID NO:798에 의해 대체된 것을 제외하고 pMON35779와 유사하다. pMON32190은 다음 세트의 프라이머 쌍 Flt40/XbaRev 및 SnaBICterm/XbaFor과 함께 PCR 주형으로서 사용되었다. 증폭 조건은 초기의 T_anneal를 66℃에서 64℃로 낮춘 것을 제외하고 앞서 pMON35771에서 설명되었던 것처럼 수행하였다. 두 겔-정제된 PCR 증폭 생성물을 NcoI/XbaI (Flt40/XbaRev PCR 생성물) 또는 XbaI/SnaBI (SnaBICterm/XbaFor PCR 생성물)로 절단하였고 pMON26430 (NcoI/SnaBI/SAP-처리된)으로 서브클로닝하였다. 38/39 Flt3L 일부를 39/40으로 재증폭하기 위해서 pMON32273 (Flt3L 1-139 (39/40)L21/IgG2b/G-CSF)를 프라이머 쌍 FltConNco/Grev과 함께 pMON35777의 PCR로 구성하였다. 정제된 암플리콘은 NcoI/SnaBI로 절단하였고, NcoI/SnaBI-절단된 pMON32191 내로 서브클로닝하여 pMON32259 (E. coli 생성을 위하여)로 명명하였다. BHK발현을 위하여, pMON32259로부터의 NcoI/HindIII 삽입물을 pMON3934 (NcoI/HindIII)로 서브클로닝하였다.

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또 다른 일련의 키메라 단백질을 구성하였고 Flt3L 파트너는 하나 또는 두 개의 Cys 돌연변이 (표 XIA 및 XIB)를 포함하였다. pMON35790 (Flt3L 1-139(C⁴ →S⁴, C⁸⁵→ S⁸⁵)/GS/G-CSF (Ser17))을 두 반응에서 주형으로서 pMON32191과 프라이머 쌍 C1For/C3Rev 및 C3For/139Rev를 사용하여 PCR로 구성하였다. pMON35791 (Flt3L 1-139(C⁹³ →S⁹³, C¹³²→ S¹³²)/GS/G-CSF (Ser17))는 주형으로서 pMON32191과 프라이머 쌍 C5For/C6Rev 및 C5Rev/N-term을 사용하여 PCR로 구성하였다. 증폭 조건은 초기 T_anneal를 66℃에서 64℃로 낮춘 것을 제외하고 pMON35771에서 설명되었던 것처럼 수행하였다. PCF의 두번째 라운드는 첫번째 라운드의 암플리콘 (각 10 ul)을 사용하여 수행되었고, PCR 생성물은 그 다음 정제되고, NcoI/SnaBI로 절단되어, NcoI/SnaBI-절단된 pMON32191로 서브클로닝 되었다. 두번째 라운드의 PCR 증폭조건은 다음과 같이 변경되었다: 초기 T_anneal를 68℃로 증가시키고, 사이클의 수를 6에서 15로 증가시켰다. 어떤 추가의 증폭도 필요하지 않았다. 이들 구조물, pMON35787 (C⁴ →S⁴, C⁸⁵→ S⁸⁵)와 pMON35788 (C⁹³ →S⁹³, C¹³²→ S¹³²)가 E. coli 발현을 위해 사용되었다. BHK 발현 동등물, pMON35790 및 35791은 NcoI/HindIII 조각으로서 바르게 돌연변이된 Flt3L/GlySer/G-CSF 키메라 삽입물을 pMON3934에 서브클로닝하여 구성하였다. pMON35792 (Flt3L 1-132(C¹³²→ S¹³²)/GlySer/G-CSF (Ser17))은 주형으로서 pMON32191과 프라이머 쌍 FLD1Rev/FltNterm을 사용하여 PCR로 구성하였다.

pMON39905 (Flt3L 1-139(C¹³²→ S¹³²)/GlySer/G-CSF (Ser17))은 주형으로서 pMON32191과 프라이머 쌍 FLM1Rev/FltNterm을 사용하여 PCR로 구성하였다. pMON39906 (Flt3L 1-139(C¹²⁷→ S¹²⁷/C¹³²→ S¹³²/GlySer/G-CSF (Ser17))는 pMON39905의 PCR 증폭시 PCR 유도된 오차의 결과물로서 서열 재배열된 Flt3L 파트너의 잔기 127에서 단일 아미노산 치환을 포함한다.

pMON32276 ((Flt3L 1-139(39/40)L21(C⁴ →S⁴, C⁸⁵→ S⁸⁵)/GlySer/G-CSF (Ser17))은 두 라운드의 PCR로 구성되었다. 세 개의 초기 암플리콘이 생성되었다: PCR1(pMON32190 주형 및 프라이머 쌍 G10L/85N); PCR7 (pMON32190 주형 및 프라이머 쌍 4N/85S); 및 PCR4(pMON32198 주형 및 프라이머 쌍 4S/3605Rev). 두 번째 라운드를 위해서, PCR1, 4 및 7을 조합된 혼합물에 다시 증폭시키고, PCR A를 얻었다. PCR A를 정제하였고, NcoI/SnaBI로 절단하고, pMON30277 (GlySer/G-CSF)로 서브클로닝하였다. 그 다음 세 개의 구조물이 유사한 방법으로 생성되었다. pMON32277 (G-CSF(Ser17)/IgG2B/Flt3L 1-139(39/40)L21(C⁴ →S⁴, C⁸⁵→ S⁸⁵)) 첫번째 라운드 PCR은 세개의 초기 암플리콘을 생성하였다: PCR1 (pMON32190 주형 및 프라이머 쌍 G10L/85N); PCR7 (pMON32190 주형 및 프라이머 쌍 4N/85S); 및 PCR 6(pMON32169 주형 및 프라이머 쌍 4S/3605Rev). 두 번째 라운드를 위해서, PCR1, 6 및 7을 조합된 혼합물에 재증폭시키고, PCR B를 얻었다. PCR B를 정제하고, NcoI/HindIII로 절단한 후, NcoI/HindIII로 절단된 pMON30309 (G-CSF(Ser17)/IgG2B)로 서브클로닝하였다. 그 다음 세 개의 구조물이 유사한 방법으로 생성되었다. pMON32278 (Flt3L 1-139(39/40)L21(C⁹³ →S⁹³, C¹³²→ S ¹³²)/GlySer/G-CSF (Ser17)) 첫번째 라운드 PCR은 세개의 초기 암플리콘을 생성하였다: PCR2 (pMON32190 주형 및 프라이머 쌍 G10L/93N); PCR 8 (pMON32190 주형 및 프라이머 쌍 132N/93S); 및 PCR 3 (pMON32198 주형 및 프라이머 쌍 132S/3605Rev). 두 번째 라운드를 위해서, PCR2, 3 및 8을 조합된 혼합물에 다시 증폭시키고, PCR C를 얻었다. PCR C를 정제하고, NcoI/SnaBI로 절단한 후, pMON30277 (GlySer/G-CSF)로 서브클로닝하였다. pMON32279 G-CSF (Ser17)/IgG2B/Flt3L 1-139(39/40)L21(C⁹³ →S⁹³, C¹³²→ S¹³²)) 첫번째 라운드 PCR은 세개의 초기 암플리콘을 생성하였다: PCR2 (pMON32190 주형 및 프라이머 쌍 G10L/93N); PCR 8 (pMON32190 주형 및 프라이머 쌍 132N/93S); 및 PCR 5 (pMON32169 주형 및 프라이머 쌍 132N/3605Rev). 두 번째 라운드를 위해서, PCR2, 5 및 8을 조합된 혼합물에 다시 증폭시키고, PCR D를 얻었다. PCR D를 정제하고, NcoI/HindIII로 절단한 후, NcoI/HindIII-절단된 pMON30309 (G-CSF(Ser17)/IgG2B)로 서브클로닝하였다.

실시예 112

pMON39909 (Flt3L 1-139(39/40)L21/GS/G-CSF (Ser17))(133/132))는 서열된 단백질 둘다 재배열된 두개의 Flt3/G-CSF 키메라 단백질 중 하나이다. Flt3L 1-139(39/40)L21/GlySer 유전자로 이루어지는 pMON32198로부터의 NcoI/AflIII 조각을 NcoI/SAP-처리한 pMON25187 (G-CSF(Ser17)(133/132)의 단일 복제물을 포함하는 E. coli 생성 플라스미드)에 서브클로닝하였다. 이어서 DNA 서열 확인 후, 키메라 삽입물은 NcoI/HindIII 조각으로서 pMON3934에 서브클로닝하였고, pMON39909로 명명되었다. pMON39910 (G-CSF (Ser17))(133/132/IgG2B/Flt3L 1-139(39/40)L21)은 주형으로서 pMON25187과 프라이머 쌍 GPFor1/GPRev2를 사용하여 PCR로 구성하였다. 증폭조건은 pMON39908에 사용되었던 것과 동일하였다. NcoI/SnaBI-절단된 G-CSF(Ser17)(133/132)는 IgG2B/Flt3L 1-139(39/40)L21 유전자를 포함하는 pMON32376의 NcoI/SnaBI 부위에 서브클로닝하였다.

실시예 113

pMON40000은 NS0 세포(pMON32169는 BHK 동등물)에서 발현시키기 위해 G-CSF (Ser17)/GlySer/Flt3L 1-139(39/40)L21을 포함하는 pC1neo (Promega)에서 변형된 제조 플라스미드이다. pMON40000은 CMV IE 프로모터/인헨서 성분, CSF (Ser17)/GlySer/Flt3L 1-139(39/40)L21의 바로 상부 IL-3 리더 서열, 절단된 타이미딘 키나제 프로모터, SV40 마지막의 Poly A 신호 서열 및 몇가지의 DNAse 1 과민감성 부위(IgH 3 분 LCR의 일부)를 포함한다.

실시에 114

다기능 키메라 조혈세포 수용체 아고니스트

시험관내 다기능 키메라 조혈세포 수용체 아고니스트 생물학적 정량법

클론	BAF3/FLT3L 증식¹	BAF3/FLT3L 증식²	CFU-GM 콜로니³
pMON30247	++	+	+
pMON32169		+++	+++
pMON32175		+++
pMON32190		+++
pMON32191		+++	+++
pMON32333	+
pMON32342	++
pMON32352	+		+
pMON32360	+		+
pMON35766	+
pMON40000			+++
pMON40002⁴		++	+++
범례:+: 콘트롤과 비교하여 감소된 효능(오른쪽으로 이동)++: 콘트롤에 동등한 효능 (2배이내)+++: 콘트롤과 비교하여 증가된 효능(왼쪽으로 이동) ¹비교된 콘트롤: pMON30247 ²비교된 콘트롤: pMON32352 ³적당한 함께 첨가된 콘트롤에 비교됨 ⁴클론 pMON40000 및 pMON40002의 푸울에서 분석됨

실시예 115

생활성 측정

체외 다기능 키메라 조혈세포 수용체 아고니스트 생물학적 정량법

클론	체외에서 조혈세포의 팽창¹			체외에서수상 세포의 팽창²
	폴드팽창	호중구전구체	거대세포전구체	폴드팽창	기능
pMON32175	+	+	+
pMON32191	+	+	++	++	++
pMON32360	+	+	+	++
IL-3 수용체 아고니스트 I, MFR 수용체 아고니스트 I, MFR 수용체 아고니스트 II	++	++	++
IL-3 수용체 아고니스트 I, MFR 수용체 아고니스트 I, MFR 수용체 아고니스트 II,pMON30247	+++	++	+++
IL-3 수용체 아고니스트 I, MFR 수용체 아고니스트 I, MFR 수용체 아고니스트 II,pMON32360	+++	++	++
IL-3 수용체 아고니스트 I, MFR 수용체 아고니스트 I, MFR 수용체 아고니스트 II,pMON32333	++	++	++
IL-3 수용체 아고니스트 I, MFR 수용체 아고니스트 I, MFR 수용체 아고니스트 II,pMON32191	+++	+++	+++
IL-3 수용체 아고니스트 I, MFR 수용체 아고니스트 I, MFR 수용체 아고니스트 II,pMON32175	++	+++	+++
IL-3 수용체 아고니스트 I, MFR 수용체 아고니스트 I, MFR 수용체 아고니스트 II,pMON32191	+	+	+++
pMON30247				+++	++
pMON32352				++
¹범례:+: IL-3, IL-6, SCF, G-CSF(문헌 콘트롤)에 비하여 감소된 활성++: IL-3, IL-6, SCF, G-CSF(문헌 콘트롤)과 동일한 활성+++: IL-3, IL-6, SCF, G-CSF(문헌 콘트롤)에 비하여 증가된 활성배양 조건: X-Vivo 10배지, 37℃, 5CO₂, 11일 배양 ²범례:+: GM-CSF, TNFa, SCF(문헌 콘트롤)에 비하여 감소된 활성++: GM-CSF, TNFa, SCF(문헌 콘트롤)과 동일한 활성(20이내)+++: GM-CSF, TNFa, SCF(문헌 콘트롤)에 비하여 증가된 활성배양 조건: 100ng/ml GM-CSF, 100ng/ml TNFa, 20ng/ml SCF로 보충한 IMDM-20배지, 37℃/5CO₂에서 18-22일동안.MFR 아고니스트 I=pMON31140(WO 95/21197)MFR 아고니스트 II=pMON28571(WO 97/12985)

조혈세포 체외 팽창 검정

사람의 골수로부터의 CD34⁺가 풍부한 선구체 세포가 분리되었고 시토카인 팽창 효능을 평가하기 위하여 시험 시토카인과 콘트롤과 함께 X-Vivo 10 + 1HSA 중 5x10⁴ 세포/ml로 배양하였다. 세포는 팽창되었고 세포 성장에 따라서 약 5일쯤 새로운 배지와 시토카인과 함께 5x10⁴ 세포/ml로 판상으로 깔았다. 10일에 세포를 수거하였고 특성을 규명하였다. 세포는 플레이트로부터 회수하였고, 1x10⁶ 세포/ml의 농도로 희석하였다. 총세포 팽창을 결정하고 세포는 메틸셀룰로오스에서 CFU Pre- and Post 팽창(Stem Cell Technologies, MethocultHCC3435)에 의해서 조혈선구세포를 특성규명하였다. 팽창된 세포는 또한 계통 특이 표현형을 위해 흘림 세포계측기로 특성규명하였다: CD11b(PE)/CD15(FITC), CD34 (FITC), CD41a (FITC).

수상세포 체외 팽창 검정

사람의 골수로부터의 CD34⁺가 풍부한 선구체 세포를 분리하였고 팽창 효능을 평가하기 위하여 시험 시토카인과 콘트롤과 함께 IMDM/20FCS 중 2x10⁵ 세포/ml로 배양하였다. 세포는 팽창되었고 세포 성장에 따라서 약 5일쯤 새로운 배지와 시토카인과 함께 5x10⁴ 세포/ml로 판상으로 깔았다. 18-22일에 세포를 수거하였고 특성을 규명하였다. 세포는 플레이트로부터 회수하였고, 1x10⁶ 세포/ml의 농도로 희석하였다. 총세포 팽창을 결정하고 세포는 계통 특이 표현형을 위해 흘림 세포계측기로 특성규명하였다: HLA-DR+(PE)/CD1a+(FITC), CD86+(PE)/CD1a+(FITC), CD19-(FITC). 수상세포 폴드 팽창은 총세포팽창 xHLA-DR+/CD1a+로 결정되었다. 세포의 기능적인 활성은 1-방향 혼합된 백혈구반응을 사용하여 결정하였다. 세척하고, 조사(照射)하고, 배양된 수상세포는 96-웰 마이크로타이터 플레이트에서 동종의 반응자 말초혈 단핵세포에 증량하며 가했다. 항원 제공 세포로서 작용하는 수상세포의 활성은 ³H 타이미딘 결합에 의해 측정되는 것으로 반응하는 세포 제조물에서 자극된 증식도로 결정한다.

실시예 116

수용체 결합

수용체 결합 분석

화합물	FIt3-Fc	G-CSFR	IL-3R"
	K_d(nM)	IC₅₀(nM)	IC₅₀(nM)
pMON32342	26 " 7	-	>1000
pMON30247	36 " 7	-	6.6 " 0.5
pMON32360	45 " 17	-	26(2)
pMON32352	56 " 5	-	13 " 4
pMON32191	37 " 14	0.33 " 0.01	-
IL-3 수용체 아고니스트 II	-	>1000	1.3 " 0.2
IL-3 수용체 아고니스트 I	-	>1000	3.7 " 0.6
G-CSF	-	069 " 0.08	>100
pMON32360이 2번의 실험으로 완성한 것을 제외하고 데이타는 세번의 중복으로 결정된 적어도 세 실험으로부터의 평균 "SEM으로 표현된다.

키메라 분자를 포함하는 Flt-3 아고니스트의 친화도는 수용체 결합 검정으로 측정되었다. BIACORE 분석은 직접 이동시키지 못하는 Flt3-FC와 결합 및 해리 속도 상수로 결정되는 것으로부터의 Kd 값으로 수행하였다. 경쟁적인 결합 검정은 키메라 분자가 BaF3 세포에서 트랜스펙션된 G-CSF 수용체나 BHK 세포에서 발현된 IL-3 수용체의 "서브유니트와의 작용을 측정하기 위해 이용하였다. 아고니스트-특이 방사선리간드를 적용한 이들 세포를 사용한 경쟁실험과 IC₅₀ 값은 용량-반응 곡선의 로짓-로그 분석을 사용하여 경쟁적인 키메라를 위해 산출했다.

실시예 117

체내 생활성

쥐의 체내 다기능 키메라 조혈 수용체 아고니스트 검정 데이타

클론	말초혈		비장
	I-A^b+/CD11c⁺	I-A^b+/CD8⁺	I-A^b+/CD11c⁺	I-A^b+/CD8⁺	CFU-GM/비장
	DC 세포/ul 혈액		DC 세포/비장(x 10⁶)		폴드 증가
pMON30247	ND	ND	33.5	23.8	78
pMON32342	ND	ND	8.0	4.5	2
pMON32360	ND	ND	64.5	37.5	183
pMON32191	17,089	2,379	133.5	78.9	53

C57BL/6 마우스를 10일동안 pMON30247, pMON32342 또는 pMON32360 (150 ug/일) 또는 pMON32191(200ug/일) 또는 마우스 혈청 알부민 (MSA, 200 ug/일)를 가지고 s.c로 주사하였다. 11일에 마지막 출혈을 심장을 찔러 수행하였다. 백혈구 수를 전체 혈액상에서 얻었다. 말초혈 백혈구를 구배 원심분리 (Histopague)에 의해 얻었고 적혈구를 더 제거하기 위해서 염화암모늄 용혈을 실시하였다. 세포는 단일항체 항원이 접합된 직접 플루오레신 또는 피코에리트린(Pharmingen)을 사용하여 흘림 세포계측기용으로 염색하였다. 염색하기에 앞서, 비-특이적 Fc 수용체 결합은 FcBlock (Pharmingen)을 사용하여 차단하였다.

백분율 양성 세포는 적분으로 결정하였고, 표현형 계산은 WBC 수를 기본으로 하여 계산하였다. 처치된 동물으로부터의 비장은 바늘이 있는 RPMI 배지에서 무균적으로 제거되었고, 산산히 떨어지게 빗었다. 세포 현탁액은 5cc 주사기 플런저의 평평한 끝을 사용하여 얻었고, 이어서 덩어리를 제거하기 위해 면마개를 통과시텨 여과하였다. 적혈구는 염화암모늄 용혈로 제거하였고, 세포를 세척한 후, 재현탁하였고, Coulter counter (Coulter Electronics)를 사용하여 계산하였다. 세포는 상기 설명한 것과 같이 흘림 세포계수기용으로 제조되었다. 표현형은 양성 표현셩과 총 비장 WBC 수를 기본으로 하여 세포수/비장으로 나타내었다. CFU 배양물은 쥐 시토카인 w/o 에리트로포이에틴(Stem Cell Technologies)을 가진 메틸셀룰로오스의 3중 웰에서 1.5×10⁵ 비장세포/1ml를 판상으로 깔아 얻었다. 배양물은 37℃에서 10일동안 배양하였고, 역상 현미경 상에서 계산하였다. CFU는 50 세포를 초과하는 세포의 콜로니로 한정했다. CFU/비장의 폴드 증가를 결정하였다(CFU의 총수/시험 화합물의 비장/CFU의 총수/MSA 콘트롤의 비장). 말초혈의 MSA 콘트롤 값은 A^b+/CD11c⁺ 와 I-A^b+/CD8⁺을 위해 각각 15와 347 세포/ul이다. 비장 백혈구의 MSA 콘트롤 값은 I-A^b+/CD11c⁺ 와 I-A^b+/CD8⁺을 위해 각각 15와 347 세포/ul이다.

더이상의 노력없이, 당업자는 전술한 설명을 이용하여, 본 발명을 그것의 충분한 범위까지 이용할 수 있다. 다음의 바람직한 특정 구체화는, 그러므로, 어떤 식으로든 여분의 개시에 제한되지 않고 단순하게 예증으로서 해석된다.

분자 생물학 기법에 관한 더 자세한 설명, WO 94/12639, WO 94/12638, WO 95/20976, WO 95/21197, WO 94/20977, WO 95/21254, WO 96/23888에서 찾을 수 있는 단백질 정제 및 생물학적 정량은 여기에 참고자료로서 그것의 전체를 삽입하였다.

여기에 인용된 모든 참고자료, 특허 또는 출원은 여기에 씌여 있는 것처럼 참고자료로서 그것의 전체를 삽입하였다.

본 개시를 읽어본 후, 다양한 다른 실시예가 본 발명의 정신과 범위에 벗어남없이 당업자에게 명백할 것이다. 모든 그러한 다른 예를 첨가한 청구항의 범위 내로 포함하고자 한다.

<110> G.D. SEARLE & CO. <120> MULTI-FUNCTIONAL CHIMERIC HEMATOPOIETIC RECEPTOR AGONISTS <130> 1 <150> US 60/029,629 <151> 1996-10-25 <160> 865 <170> KOPATIN 1.0 <210> 1 <211> 439 <212> DNA <213> Homo sapiens <400> 1 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgt 439 <210> 2 <211> 465 <212> DNA <213> Homo sapiens <400> 2 tccccagctc cacctgcttg tgacctccga gtcctcagta aactgcttcg tgactcccat 60 gtccttcaca gcagactgag ccagtgccca gaggttcacc ctttgcctac acctgtcctg 120 ctgcctgctg tggactttag cttgggagaa tggaaaaccc agatggagga gaccaaggca 180 caggacattc tgggagcagt gacccttctg ctggagggag tgatggcagc acggggacaa 240 ctgggaccca cttgcctctc atccctcctg gggcagcttt ctggacaggt ccgtctcctc 300 cttggggccc tgcagagcct ccttggaacc cagcttcctc cacagggcag gaccacagct 360 cacaaggatc ccaatgccat cttcctgagc ttccaacacc tgctccgagg aaaggtgcgt 420 ttcctgatgc ttgtaggagg gtccaccctc tgcgtcaggg aattc 465 <210> 3 <211> 927 <212> DNA <213> Homo sapiens <400> 3 tccccagctc cacctgcttg tgacctccga gtcctcagta aactgcttcg tgactcccat 60 gtccttcaca gcagactgag ccagtgccca gaggttcacc ctttgcctac acctgtcctg 120 ctgcctgctg tggactttag cttgggagaa tggaaaaccc agatggagga gaccaaggca 180 caggacattc tgggagcagt gacccttctg ctggagggag tgatggcagc acggggacaa 240 ctgggaccca cttgcctctc atccctcctg gggcagcttt ctggacaggt ccgtctcctc 300 cttggggccc tgcagagcct ccttggaacc cagcttcctc cacagggcag gaccacagct 360 cacaaggatc ccaatgccat cttcctgagc ttccaacacc tgctccgagg aaaggtgcgt 420 ttcctgatgc ttgtaggagg gtccaccctc tgcgtcaggg aattcggcgg caacatggcg 480 tctcccgctc cgcctgcttg tgacctccga gtcctcagta aactgcttcg tgactcccat 540 gtccttcaca gcagactgag ccagtgccca gaggttcacc ctttgcctac acctgtcctg 600 ctgcctgctg tggactttag cttgggagaa tggaaaaccc agatggagga gaccaaggca 660 caggacattc tgggagcagt gacccttctg ctggagggag tgatggcagc acggggacaa 720 ctgggaccca cttgcctctc atccctcctg gggcagcttt ctggacaggt ccgtctcctc 780 cttggggccc tgcagagcct ccttggaacc cagggcagga ccacagctca caaggatccc 840 aatgccatct tcctgagctt ccaacacctg ctccgaggaa aggtgcgttt cctgatgctt 900 gtaggagggt ccaccctctg cgtcagg 927 <210> 4 <211> 936 <212> DNA <213> Homo sapiens <400> 4 tccccagctc cacctgcttg tgacctccga gtcctcagta aactgcttcg tgactcccat 60 gtccttcaca gcagactgag ccagtgccca gaggttcacc ctttgcctac acctgtcctg 120 ctgcctgctg tggactttag cttgggagaa tggaaaaccc agatggagga gaccaaggca 180 caggacattc tgggagcagt gacccttctg ctggagggag tgatggcagc acggggacaa 240 ctgggaccca cttgcctctc atccctcctg gggcagcttt ctggacaggt ccgtctcctc 300 cttggggccc tgcagagcct ccttggaacc cagcttcctc cacagggcag gaccacagct 360 cacaaggatc ccaatgccat cttcctgagc ttccaacacc tgctccgagg aaaggtgcgt 420 ttcctgatgc ttgtaggagg gtccaccctc tgcgtcaggg aattcggcaa catggcgtct 480 cccgctccgc ctgcttgtga cctccgagtc ctcagtaaac tgcttcgtga ctcccatgtc 540 cttcacagca gactgagcca gtgcccagag gttcaccctt tgcctacacc tgtcctgctg 600 cctgctgtgg actttagctt gggagaatgg aaaacccaga tggaggagac caaggcacag 660 gacattctgg gagcagtgac ccttctgctg gagggagtga tggcagcacg gggacaactg 720 ggacccactt gcctctcatc cctcctgggg cagctttctg gacaggtccg tctcctcctt 780 ggggccctgc agagcctcct tggaacccag cttcctccac agggcaggac cacagctcac 840 aaggatccca atgccatctt cctgagcttc caacacctgc tccgaggaaa ggtgcgtttc 900 ctgatgcttg taggagggtc caccctctgc gtcagg 936 <210> 5 <211> 939 <212> DNA <213> Homo sapiens <400> 5 tccccagctc cacctgcttg tgacctccga gtcctcagta aactgcttcg tgactcccat 60 gtccttcaca gcagactgag ccagtgccca gaggttcacc ctttgcctac acctgtcctg 120 ctgcctgctg tggactttag cttgggagaa tggaaaaccc agatggagga gaccaaggca 180 caggacattc tgggagcagt gacccttctg ctggagggag tgatggcagc acggggacaa 240 ctgggaccca cttgcctctc atccctcctg gggcagcttt ctggacaggt ccgtctcctc 300 cttggggccc tgcagagcct ccttggaacc cagcttcctc cacagggcag gaccacagct 360 cacaaggatc ccaatgccat cttcctgagc ttccaacacc tgctccgagg aaaggtgcgt 420 ttcctgatgc ttgtaggagg gtccaccctc tgcgtcaggg aattcggcgg caacatggcg 480 tctcccgctc cgcctgcttg tgacctccga gtcctcagta aactgcttcg tgactcccat 540 gtccttcaca gcagactgag ccagtgccca gaggttcacc ctttgcctac acctgtcctg 600 ctgcctgctg tggactttag cttgggagaa tggaaaaccc agatggagga gaccaaggca 660 caggacattc tgggagcagt gacccttctg ctggagggag tgatggcagc acggggacaa 720 ctgggaccca cttgcctctc atccctcctg gggcagcttt ctggacaggt ccgtctcctc 780 cttggggccc tgcagagcct ccttggaacc cagcttcctc cacagggcag gaccacagct 840 cacaaggatc ccaatgccat cttcctgagc ttccaacacc tgctccgagg aaaggtgcgt 900 ttcctgatgc ttgtaggagg gtccaccctc tgcgtcagg 939 <210> 6 <211> 948 <212> DNA <213> Homo sapiens <400> 6 tccccagcgc cgcctgcttg tgacctccga gtcctcagta aactgcttcg tgactcccat 60 gtccttcaca gcagactgag ccagtgccca gaggttcacc ctttgcctac acctgtcctg 120 ctgcctgctg tggactttag cttgggagaa tggaaaaccc agatggagga gaccaaggca 180 caggacattc tgggagcagt gacccttctg ctggagggag tgatggcagc acggggacaa 240 ctgggaccca cttgcctctc atccctcctg gggcagcttt ctggacaggt ccgtctcctc 300 cttggggccc tgcagagcct ccttggaacc cagcttcctc cacagggcag gaccacagct 360 cacaaggatc ccaatgccat cttcctgagc ttccaacacc tgctccgagg aaaggtgcgt 420 ttcctgatgc ttgtaggagg gtccaccctc tgcgtcaggg aattcggcgg caacggcggc 480 aacatggcgt ccccagcgcc gcctgcttgt gacctccgag tcctcagtaa actgcttcgt 540 gactcccatg tccttcacag cagactgagc cagtgcccag aggttcaccc tttgcctaca 600 cctgtcctgc tgcctgctgt ggactttagc ttgggagaat ggaaaaccca gatggaggag 660 accaaggcac aggacattct gggagcagtg acccttctgc tggagggagt gatggcagca 720 cggggacaac tgggacccac ttgcctctca tccctcctgg ggcagctttc tggacaggtc 780 cgtctcctcc ttggggccct gcagagcctc cttggaaccc agcttcctcc acagggcagg 840 accacagctc acaaggatcc caatgccatc ttcctgagct tccaacacct gctccgagga 900 aaggtgcgtt tcctgatgct tgtaggaggg tccaccctct gcgtcagg 948 <210> 7 <211> 688 <212> DNA <213> Homo sapiens <400> 7 catggctaac tgctctataa tgatcgatga aattatacat cacttaaaga gaccacctgc 60 acctttgctg gacccgaaca acctcaatga cgaagacgtc tctatcctga tggaccgaaa 120 ccttcgactt ccaaacctgg agagcttcgt aagggctgtc aagaacttag aaaatgcatc 180 aggtattgag gcaattcttc gtaatctcca accatgtctg ccctctgcca cggccgcacc 240 ctctcgacat ccaatcatca tcaaggcagg tgactggcaa gaattccggg aaaaactgac 300 gttctatctg gttacccttg agcaagcgca ggaacaacag ggtggtggct ctaactgctc 360 tataatgatc gatgaaatta tacatcactt aaagagacca cctgcacctt tgctggaccc 420 gaacaacctc aatgacgaag acgtctctat cctgatggac cgaaaccttc gacttccaaa 480 cctggagagc ttcgtaaggg ctgtcaagaa cttagaaaat gcatcaggta ttgaggcaat 540 tcttcgtaat ctccaaccat gtctgccctc tgccacggcc gcaccctctc gacatccaat 600 catcatcaag gcaggtgact ggcaagaatt ccgggaaaaa ctgacgttct atctggttac 660 ccttgagcaa gcgcaggaac aacagtac 688 <210> 8 <211> 712 <212> DNA <213> Homo sapiens <400> 8 catggctaac tgctctataa tgatcgatga aattatacat cacttaaaga gaccacctgc 60 acctttgctg gacccgaaca acctcaatga cgaagacgtc tctatcctga tggaccgaaa 120 ccttcgactt ccaaacctgg agagcttcgt aagggctgtc aagaacttag aaaatgcatc 180 aggtattgag gcaattcttc gtaatctcca accatgtctg ccctctgcca cggccgcacc 240 ctctcgacat ccaatcatca tcaaggcagg tgactggcaa gaattccggg aaaaactgac 300 gttctatctg gttacccttg agcaagcgca ggaacaacag ggtggtggct ctggcggtgg 360 cagcggcggc ggttctaact gctctataat gatcgatgaa attatacatc acttaaagag 420 accacctgca cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat 480 ggaccgaaac cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga 540 aaatgcatca ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac 600 ggccgcaccc tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga 660 aaaactgacg ttctatctgg ttacccttga gcaagcgcag gaacaacagt ac 712 <210> 9 <211> 975 <212> DNA <213> Homo sapiens <400> 9 atggctctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 60 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 120 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 180 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 240 ttctatctgg ttacccttga gcaagcgcag gaacaacagg gtggtggctc taactgctct 300 ataatgatcg atgaaattat acatcactta aagagaccac ctgcaccttt gtacgtagag 360 ggcggtggag gctccccggg tgaaccgtct ggtccaatct ctactatcaa cccgtctcct 420 ccgtctaaag aatctcataa atctccaaac atggctaccc agggtgccat gccggccttc 480 gcctctgctt tccagcgccg ggcaggaggg gtcctggttg ctagccatct gcagagcttc 540 ctggaggtgt cgtaccgcgt tctacgccac cttgcgcagc cctctggcgg ctctggcggc 600 tctcagagct tcctgctcaa gtctttagag caagtgagaa agatccaggg cgatggcgca 660 gcgctccagg agaagctgtg tgccacctac aagctgtgcc accccgagga gctggtgctg 720 ctcggacact ctctgggcat cccctgggct cccctgagct cctgccccag ccaggccctg 780 cagctggcag gctgcttgag ccaactccat agcggccttt tcctctacca ggggctcctg 840 caggccctgg aagggatatc ccccgagttg ggtcccacct tggacacact gcagctggac 900 gtcgccgact ttgccaccac catctggcag cagatggaag aactgggaat ggcccctgcc 960 ctgcagccct aataa 975 <210> 10 <211> 975 <212> DNA <213> Homo sapiens <400> 10 atggctaatg catcaggtat tgaggcaatt cttcgtaatc tccaaccatg tctgccctct 60 gccacggccg caccctctcg acatccaatc atcatcaagg caggtgactg gcaagaattc 120 cgggaaaaac tgacgttcta tctggttacc cttgagcaag cgcaggaaca acagggtggt 180 ggctctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 240 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 300 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga atacgtagag 360 ggcggtggag gctccccggg tgaaccgtct ggtccaatct ctactatcaa cccgtctcct 420 ccgtctaaag aatctcataa atctccaaac atggctaccc agggtgccat gccggccttc 480 gcctctgctt tccagcgccg ggcaggaggg gtcctggttg ctagccatct gcagagcttc 540 ctggaggtgt cgtaccgcgt tctacgccac cttgcgcagc cctctggcgg ctctggcggc 600 tctcagagct tcctgctcaa gtctttagag caagtgagaa agatccaggg cgatggcgca 660 gcgctccagg agaagctgtg tgccacctac aagctgtgcc accccgagga gctggtgctg 720 ctcggacact ctctgggcat cccctgggct cccctgagct cctgccccag ccaggccctg 780 cagctggcag gctgcttgag ccaactccat agcggccttt tcctctacca ggggctcctg 840 caggccctgg aagggatatc ccccgagttg ggtcccacct tggacacact gcagctggac 900 gtcgccgact ttgccaccac catctggcag cagatggaag aactgggaat ggcccctgcc 960 ctgcagccct aataa 975 <210> 11 <211> 975 <212> DNA <213> Homo sapiens <400> 11 atggctgcac cctctcgaca tccaatcatc atcaaggcag gtgactggca agaattccgg 60 gaaaaactga cgttctatct ggttaccctt gagcaagcgc aggaacaaca gggtggtggc 120 tctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 180 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 240 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 300 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc ctacgtagag 360 ggcggtggag gctccccggg tgaaccgtct ggtccaatct ctactatcaa cccgtctcct 420 ccgtctaaag aatctcataa atctccaaac atggctaccc agggtgccat gccggccttc 480 gcctctgctt tccagcgccg ggcaggaggg gtcctggttg ctagccatct gcagagcttc 540 ctggaggtgt cgtaccgcgt tctacgccac cttgcgcagc cctctggcgg ctctggcggc 600 tctcagagct tcctgctcaa gtctttagag caagtgagaa agatccaggg cgatggcgca 660 gcgctccagg agaagctgtg tgccacctac aagctgtgcc accccgagga gctggtgctg 720 ctcggacact ctctgggcat cccctgggct cccctgagct cctgccccag ccaggccctg 780 cagctggcag gctgcttgag ccaactccat agcggccttt tcctctacca ggggctcctg 840 caggccctgg aagggatatc ccccgagttg ggtcccacct tggacacact gcagctggac 900 gtcgccgact ttgccaccac catctggcag cagatggaag aactgggaat ggcccctgcc 960 ctgcagccct aataa 975 <210> 12 <211> 975 <212> DNA <213> Homo sapiens <400> 12 atggctgcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 60 gagcaagcgc aggaacaaca gggtggtggc tctaactgct ctataatgat cgatgaaatt 120 atacatcact taaagagacc acctgcacct ttgctggacc cgaacaacct caatgacgaa 180 gacgtctcta tcctgatgga ccgaaacctt cgacttccaa acctggagag cttcgtaagg 240 gctgtcaaga acttagaaaa tgcatcaggt attgaggcaa ttcttcgtaa tctccaacca 300 tgtctgccct ctgccacggc cgcaccctct cgacatccaa tcatcatcaa gtacgtagag 360 ggcggtggag gctccccggg tgaaccgtct ggtccaatct ctactatcaa cccgtctcct 420 ccgtctaaag aatctcataa atctccaaac atggctaccc agggtgccat gccggccttc 480 gcctctgctt tccagcgccg ggcaggaggg gtcctggttg ctagccatct gcagagcttc 540 ctggaggtgt cgtaccgcgt tctacgccac cttgcgcagc cctctggcgg ctctggcggc 600 tctcagagct tcctgctcaa gtctttagag caagtgagaa agatccaggg cgatggcgca 660 gcgctccagg agaagctgtg tgccacctac aagctgtgcc accccgagga gctggtgctg 720 ctcggacact ctctgggcat cccctgggct cccctgagct cctgccccag ccaggccctg 780 cagctggcag gctgcttgag ccaactccat agcggccttt tcctctacca ggggctcctg 840 caggccctgg aagggatatc ccccgagttg ggtcccacct tggacacact gcagctggac 900 gtcgccgact ttgccaccac catctggcag cagatggaag aactgggaat ggcccctgcc 960 ctgcagccct aataa 975 <210> 13 <211> 999 <212> DNA <213> Homo sapiens <400> 13 atggctctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 60 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 120 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 180 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 240 ttctatctgg ttacccttga gcaagcgcag gaacaacagg gtggtggctc tggcggtggc 300 agcggcggcg gttctaactg ctctataatg atcgatgaaa ttatacatca cttaaagaga 360 ccacctgcac ctttgtacgt agagggcggt ggaggctccc cgggtgaacc gtctggtcca 420 atctctacta tcaacccgtc tcctccgtct aaagaatctc ataaatctcc aaacatggct 480 acccagggtg ccatgccggc cttcgcctct gctttccagc gccgggcagg aggggtcctg 540 gttgctagcc atctgcagag cttcctggag gtgtcgtacc gcgttctacg ccaccttgcg 600 cagccctctg gcggctctgg cggctctcag agcttcctgc tcaagtcttt agagcaagtg 660 agaaagatcc agggcgatgg cgcagcgctc caggagaagc tgtgtgccac ctacaagctg 720 tgccaccccg aggagctggt gctgctcgga cactctctgg gcatcccctg ggctcccctg 780 agctcctgcc ccagccaggc cctgcagctg gcaggctgct tgagccaact ccatagcggc 840 cttttcctct accaggggct cctgcaggcc ctggaaggga tatcccccga gttgggtccc 900 accttggaca cactgcagct ggacgtcgcc gactttgcca ccaccatctg gcagcagatg 960 gaagaactgg gaatggcccc tgccctgcag ccctaataa 999 <210> 14 <211> 999 <212> DNA <213> Homo sapiens <400> 14 atggctaatg catcaggtat tgaggcaatt cttcgtaatc tccaaccatg tctgccctct 60 gccacggccg caccctctcg acatccaatc atcatcaagg caggtgactg gcaagaattc 120 cgggaaaaac tgacgttcta tctggttacc cttgagcaag cgcaggaaca acagggtggt 180 ggctctggcg gtggcagcgg cggcggttct aactgctcta taatgatcga tgaaattata 240 catcacttaa agagaccacc tgcacctttg ctggacccga acaacctcaa tgacgaagac 300 gtctctatcc tgatggaccg aaaccttcga cttccaaacc tggagagctt cgtaagggct 360 gtcaagaact tagaatacgt agagggcggt ggaggctccc cgggtgaacc gtctggtcca 420 atctctacta tcaacccgtc tcctccgtct aaagaatctc ataaatctcc aaacatggct 480 acccagggtg ccatgccggc cttcgcctct gctttccagc gccgggcagg aggggtcctg 540 gttgctagcc atctgcagag cttcctggag gtgtcgtacc gcgttctacg ccaccttgcg 600 cagccctctg gcggctctgg cggctctcag agcttcctgc tcaagtcttt agagcaagtg 660 agaaagatcc agggcgatgg cgcagcgctc caggagaagc tgtgtgccac ctacaagctg 720 tgccaccccg aggagctggt gctgctcgga cactctctgg gcatcccctg ggctcccctg 780 agctcctgcc ccagccaggc cctgcagctg gcaggctgct tgagccaact ccatagcggc 840 cttttcctct accaggggct cctgcaggcc ctggaaggga tatcccccga gttgggtccc 900 accttggaca cactgcagct ggacgtcgcc gactttgcca ccaccatctg gcagcagatg 960 gaagaactgg gaatggcccc tgccctgcag ccctaataa 999 <210> 15 <211> 999 <212> DNA <213> Homo sapiens <400> 15 atggctgcac cctctcgaca tccaatcatc atcaaggcag gtgactggca agaattccgg 60 gaaaaactga cgttctatct ggttaccctt gagcaagcgc aggaacaaca gggtggtggc 120 tctggcggtg gcagcggcgg cggttctaac tgctctataa tgatcgatga aattatacat 180 cacttaaaga gaccacctgc acctttgctg gacccgaaca acctcaatga cgaagacgtc 240 tctatcctga tggaccgaaa ccttcgactt ccaaacctgg agagcttcgt aagggctgtc 300 aagaacttag aaaatgcatc aggtattgag gcaattcttc gtaatctcca accatgtctg 360 ccctctgcca cggcctacgt agagggcggt ggaggctccc cgggtgaacc gtctggtcca 420 atctctacta tcaacccgtc tcctccgtct aaagaatctc ataaatctcc aaacatggct 480 acccagggtg ccatgccggc cttcgcctct gctttccagc gccgggcagg aggggtcctg 540 gttgctagcc atctgcagag cttcctggag gtgtcgtacc gcgttctacg ccaccttgcg 600 cagccctctg gcggctctgg cggctctcag agcttcctgc tcaagtcttt agagcaagtg 660 agaaagatcc agggcgatgg cgcagcgctc caggagaagc tgtgtgccac ctacaagctg 720 tgccaccccg aggagctggt gctgctcgga cactctctgg gcatcccctg ggctcccctg 780 agctcctgcc ccagccaggc cctgcagctg gcaggctgct tgagccaact ccatagcggc 840 cttttcctct accaggggct cctgcaggcc ctggaaggga tatcccccga gttgggtccc 900 accttggaca cactgcagct ggacgtcgcc gactttgcca ccaccatctg gcagcagatg 960 gaagaactgg gaatggcccc tgccctgcag ccctaataa 999 <210> 16 <211> 999 <212> DNA <213> Homo sapiens <400> 16 atggctgcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 60 gagcaagcgc aggaacaaca gggtggtggc tctggcggtg gcagcggcgg cggttctaac 120 tgctctataa tgatcgatga aattatacat cacttaaaga gaccacctgc acctttgctg 180 gacccgaaca acctcaatga cgaagacgtc tctatcctga tggaccgaaa ccttcgactt 240 ccaaacctgg agagcttcgt aagggctgtc aagaacttag aaaatgcatc aggtattgag 300 gcaattcttc gtaatctcca accatgtctg ccctctgcca cggccgcacc ctctcgacat 360 ccaatcatca tcaagtacgt agagggcggt ggaggctccc cgggtgaacc gtctggtcca 420 atctctacta tcaacccgtc tcctccgtct aaagaatctc ataaatctcc aaacatggct 480 acccagggtg ccatgccggc cttcgcctct gctttccagc gccgggcagg aggggtcctg 540 gttgctagcc atctgcagag cttcctggag gtgtcgtacc gcgttctacg ccaccttgcg 600 cagccctctg gcggctctgg cggctctcag agcttcctgc tcaagtcttt agagcaagtg 660 agaaagatcc agggcgatgg cgcagcgctc caggagaagc tgtgtgccac ctacaagctg 720 tgccaccccg aggagctggt gctgctcgga cactctctgg gcatcccctg ggctcccctg 780 agctcctgcc ccagccaggc cctgcagctg gcaggctgct tgagccaact ccatagcggc 840 cttttcctct accaggggct cctgcaggcc ctggaaggga tatcccccga gttgggtccc 900 accttggaca cactgcagct ggacgtcgcc gactttgcca ccaccatctg gcagcagatg 960 gaagaactgg gaatggcccc tgccctgcag ccctaataa 999 <210> 17 <211> 918 <212> DNA <213> Homo sapiens <400> 17 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg gtggttctgg cggcggctcc aacatggctt acaagctgtg ccaccccgag 420 gagctggtgc tgctcggaca ctctctgggc atcccctggg ctcccctgag ctcctgcccc 480 agccaggccc tgcagctggc aggctgcttg agccaactcc atagcggcct tttcctctac 540 caggggctcc tgcaggccct ggaagggata tcccccgagt tgggtcccac cttggacaca 600 ctgcagctgg acgtcgccga ctttgccacc accatctggc agcagatgga agaactggga 660 atggcccctg ccctgcagcc cacccagggt gccatgccgg ccttcgcctc tgctttccag 720 cgccgggcag gaggggtcct ggttgctagc catctgcaga gcttcctgga ggtgtcgtac 780 cgcgttctac gccaccttgc gcagccctct ggcggctctg gcggctctca gagcttcctg 840 ctcaagtctt tagagcaagt gagaaagatc cagggcgatg gcgcagcgct ccaggagaag 900 ctgtgtgcca cctaataa 918 <210> 18 <211> 963 <212> DNA <213> Homo sapiens <400> 18 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggcttacaag ctgtgccacc ccgaggagct ggtgctgctc 480 ggacactctc tgggcatccc ctgggctccc ctgagctcct gccccagcca ggccctgcag 540 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag 600 gccctggaag ggatatcccc cgagttgggt cccaccttgg acacactgca gctggacgtc 660 gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg 720 cagcccaccc agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg 780 gtcctggttg ctagccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac 840 cttgcgcagc cctctggcgg ctctggcggc tctcagagct tcctgctcaa gtctttagag 900 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctaa 960 taa 963 <210> 19 <211> 918 <212> DNA <213> Homo sapiens <400> 19 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg gtggttctgg cggcggctcc aacatggctc ccgagttggg tcccaccttg 420 gacacactgc agctggacgt cgccgacttt gccaccacca tctggcagca gatggaagaa 480 ctgggaatgg cccctgccct gcagcccacc cagggtgcca tgccggcctt cgcctctgct 540 ttccagcgcc gggcaggagg ggtcctggtt gctagccatc tgcagagctt cctggaggtg 600 tcgtaccgcg ttctacgcca ccttgcgcag ccctctggcg gctctggcgg ctctcagagc 660 ttcctgctca agtctttaga gcaagtgaga aagatccagg gcgatggcgc agcgctccag 720 gagaagctgt gtgccaccta caagctgtgc caccccgagg agctggtgct gctcggacac 780 tctctgggca tcccctgggc tcccctgagc tcctgcccca gccaggccct gcagctggca 840 ggctgcttga gccaactcca tagcggcctt ttcctctacc aggggctcct gcaggccctg 900 gaagggatat cctaataa 918 <210> 20 <211> 963 <212> DNA <213> Homo sapiens <400> 20 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggctcccgag ttgggtccca ccttggacac actgcagctg 480 gacgtcgccg actttgccac caccatctgg cagcagatgg aagaactggg aatggcccct 540 gccctgcagc ccacccaggg tgccatgccg gccttcgcct ctgctttcca gcgccgggca 600 ggaggggtcc tggttgctag ccatctgcag agcttcctgg aggtgtcgta ccgcgttcta 660 cgccaccttg cgcagccctc tggcggctct ggcggctctc agagcttcct gctcaagtct 720 ttagagcaag tgagaaagat ccagggcgat ggcgcagcgc tccaggagaa gctgtgtgcc 780 acctacaagc tgtgccaccc cgaggagctg gtgctgctcg gacactctct gggcatcccc 840 tgggctcccc tgagctcctg ccccagccag gccctgcagc tggcaggctg cttgagccaa 900 ctccatagcg gccttttcct ctaccagggg ctcctgcagg ccctggaagg gatatcctaa 960 taa 963 <210> 21 <211> 918 <212> DNA <213> Homo sapiens <400> 21 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg gtggttctgg cggcggctcc aacatggcta tggcccctgc cctgcagccc 420 acccagggtg ccatgccggc cttcgcctct gctttccagc gccgggcagg aggggtcctg 480 gttgctagcc atctgcagag cttcctggag gtgtcgtacc gcgttctacg ccaccttgcg 540 cagccctctg gcggctctgg cggctctcag agcttcctgc tcaagtcttt agagcaagtg 600 agaaagatcc agggcgatgg cgcagcgctc caggagaagc tgtgtgccac ctacaagctg 660 tgccaccccg aggagctggt gctgctcgga cactctctgg gcatcccctg ggctcccctg 720 agctcctgcc ccagccaggc cctgcagctg gcaggctgct tgagccaact ccatagcggc 780 cttttcctct accaggggct cctgcaggcc ctggaaggga tatcccccga gttgggtccc 840 accttggaca cactgcagct ggacgtcgcc gactttgcca ccaccatctg gcagcagatg 900 gaagaactgg gataataa 918 <210> 22 <211> 963 <212> DNA <213> Homo sapiens <400> 22 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggctatggcc cctgccctgc agcccaccca gggtgccatg 480 ccggccttcg cctctgcttt ccagcgccgg gcaggagggg tcctggttgc tagccatctg 540 cagagcttcc tggaggtgtc gtaccgcgtt ctacgccacc ttgcgcagcc ctctggcggc 600 tctggcggct ctcagagctt cctgctcaag tctttagagc aagtgagaaa gatccagggc 660 gatggcgcag cgctccagga gaagctgtgt gccacctaca agctgtgcca ccccgaggag 720 ctggtgctgc tcggacactc tctgggcatc ccctgggctc ccctgagctc ctgccccagc 780 caggccctgc agctggcagg ctgcttgagc caactccata gcggcctttt cctctaccag 840 gggctcctgc aggccctgga agggatatcc cccgagttgg gtcccacctt ggacacactg 900 cagctggacg tcgccgactt tgccaccacc atctggcagc agatggaaga actgggataa 960 taa 963 <210> 23 <211> 918 <212> DNA <213> Homo sapiens <400> 23 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg gtggttctgg cggcggctcc aacatggcta cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctctgg cggctctggc 540 ggctctcaga gcttcctgct caagtcttta gagcaagtga gaaagatcca gggcgatggc 600 gcagcgctcc aggagaagct gtgtgccacc tacaagctgt gccaccccga ggagctggtg 660 ctgctcggac actctctggg catcccctgg gctcccctga gctcctgccc cagccaggcc 720 ctgcagctgg caggctgctt gagccaactc catagcggcc ttttcctcta ccaggggctc 780 ctgcaggccc tggaagggat atcccccgag ttgggtccca ccttggacac actgcagctg 840 gacgtcgccg actttgccac caccatctgg cagcagatgg aagaactggg aatggcccct 900 gccctgcagc cctaataa 918 <210> 24 <211> 963 <212> DNA <213> Homo sapiens <400> 24 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggctacccag ggtgccatgc cggccttcgc ctctgctttc 480 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 540 taccgcgttc tacgccacct tgcgcagccc tctggcggct ctggcggctc tcagagcttc 600 ctgctcaagt ctttagagca agtgagaaag atccagggcg atggcgcagc gctccaggag 660 aagctgtgtg ccacctacaa gctgtgccac cccgaggagc tggtgctgct cggacactct 720 ctgggcatcc cctgggctcc cctgagctcc tgccccagcc aggccctgca gctggcaggc 780 tgcttgagcc aactccatag cggccttttc ctctaccagg ggctcctgca ggccctggaa 840 gggatatccc ccgagttggg tcccaccttg gacacactgc agctggacgt cgccgacttt 900 gccaccacca tctggcagca gatggaagaa ctgggaatgg cccctgccct gcagccctaa 960 taa 963 <210> 25 <211> 918 <212> DNA <213> Homo sapiens <400> 25 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg gtggttctgg cggcggctcc aacatggctt ctgctttcca gcgccgggca 420 ggaggggtcc tggttgctag ccatctgcag agcttcctgg aggtgtcgta ccgcgttcta 480 cgccaccttg cgcagccctc tggcggctct ggcggctctc agagcttcct gctcaagtct 540 ttagagcaag tgagaaagat ccagggcgat ggcgcagcgc tccaggagaa gctgtgtgcc 600 acctacaagc tgtgccaccc cgaggagctg gtgctgctcg gacactctct gggcatcccc 660 tgggctcccc tgagctcctg ccccagccag gccctgcagc tggcaggctg cttgagccaa 720 ctccatagcg gccttttcct ctaccagggg ctcctgcagg ccctggaagg gatatccccc 780 gagttgggtc ccaccttgga cacactgcag ctggacgtcg ccgactttgc caccaccatc 840 tggcagcaga tggaagaact gggaatggcc cctgccctgc agcccaccca gggtgccatg 900 ccggccttcg cctaataa 918 <210> 26 <211> 963 <212> DNA <213> Homo sapiens <400> 26 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggcttctgct ttccagcgcc gggcaggagg ggtcctggtt 480 gctagccatc tgcagagctt cctggaggtg tcgtaccgcg ttctacgcca ccttgcgcag 540 ccctctggcg gctctggcgg ctctcagagc ttcctgctca agtctttaga gcaagtgaga 600 aagatccagg gcgatggcgc agcgctccag gagaagctgt gtgccaccta caagctgtgc 660 caccccgagg agctggtgct gctcggacac tctctgggca tcccctgggc tcccctgagc 720 tcctgcccca gccaggccct gcagctggca ggctgcttga gccaactcca tagcggcctt 780 ttcctctacc aggggctcct gcaggccctg gaagggatat cccccgagtt gggtcccacc 840 ttggacacac tgcagctgga cgtcgccgac tttgccacca ccatctggca gcagatggaa 900 gaactgggaa tggcccctgc cctgcagccc acccagggtg ccatgccggc cttcgcctaa 960 taa 963 <210> 27 <211> 927 <212> DNA <213> Homo sapiens <400> 27 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg gtggttctgg cggcggctcc aacatggctt acaagctgtg ccaccccgag 420 gagctggtgc tgctcggaca ctctctgggc atcccctggg ctcccctgag ctcctgcccc 480 agccaggccc tgcagctggc aggctgcttg agccaactcc atagcggcct tttcctctac 540 caggggctcc tgcaggccct ggaagggata tcccccgagt tgggtcccac cttggacaca 600 ctgcagctgg acgtcgccga ctttgccacc accatctggc agcagatgga agaactggga 660 atggcccctg ccctgcagcc cacccagggt gccatgccgg ccttcgcctc tgctttccag 720 cgccgggcag gaggggtcct ggttgctagc catctgcaga gcttcctgga ggtgtcgtac 780 cgcgttctac gccaccttgc gcagcccaca ccattgggcc ctgccagctc cctgccccag 840 agcttcctgc tcaagtcttt agagcaagtg agaaagatcc agggcgatgg cgcagcgctc 900 caggagaagc tgtgtgccac ctaataa 927 <210> 28 <211> 972 <212> DNA <213> Homo sapiens <400> 28 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggcttacaag ctgtgccacc ccgaggagct ggtgctgctc 480 ggacactctc tgggcatccc ctgggctccc ctgagctcct gccccagcca ggccctgcag 540 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag 600 gccctggaag ggatatcccc cgagttgggt cccaccttgg acacactgca gctggacgtc 660 gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg 720 cagcccaccc agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg 780 gtcctggttg ctagccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac 840 cttgcgcagc ccacaccatt gggccctgcc agctccctgc cccagagctt cctgctcaag 900 tctttagagc aagtgagaaa gatccagggc gatggcgcag cgctccagga gaagctgtgt 960 gccacctaat aa 972 <210> 29 <211> 927 <212> DNA <213> Homo sapiens <400> 29 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg gtggttctgg cggcggctcc aacatggctc ccgagttggg tcccaccttg 420 gacacactgc agctggacgt cgccgacttt gccaccacca tctggcagca gatggaagaa 480 ctgggaatgg cccctgccct gcagcccacc cagggtgcca tgccggcctt cgcctctgct 540 ttccagcgcc gggcaggagg ggtcctggtt gctagccatc tgcagagctt cctggaggtg 600 tcgtaccgcg ttctacgcca ccttgcgcag cccacaccat tgggccctgc cagctccctg 660 ccccagagct tcctgctcaa gtctttagag caagtgagaa agatccaggg cgatggcgca 720 gcgctccagg agaagctgtg tgccacctac aagctgtgcc accccgagga gctggtgctg 780 ctcggacact ctctgggcat cccctgggct cccctgagct cctgccccag ccaggccctg 840 cagctggcag gctgcttgag ccaactccat agcggccttt tcctctacca ggggctcctg 900 caggccctgg aagggatatc ctaataa 927 <210> 30 <211> 972 <212> DNA <213> Homo sapiens <400> 30 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggctcccgag ttgggtccca ccttggacac actgcagctg 480 gacgtcgccg actttgccac caccatctgg cagcagatgg aagaactggg aatggcccct 540 gccctgcagc ccacccaggg tgccatgccg gccttcgcct ctgctttcca gcgccgggca 600 ggaggggtcc tggttgctag ccatctgcag agcttcctgg aggtgtcgta ccgcgttcta 660 cgccaccttg cgcagcccac accattgggc cctgccagct ccctgcccca gagcttcctg 720 ctcaagtctt tagagcaagt gagaaagatc cagggcgatg gcgcagcgct ccaggagaag 780 ctgtgtgcca cctacaagct gtgccacccc gaggagctgg tgctgctcgg acactctctg 840 ggcatcccct gggctcccct gagctcctgc cccagccagg ccctgcagct ggcaggctgc 900 ttgagccaac tccatagcgg ccttttcctc taccaggggc tcctgcaggc cctggaaggg 960 atatcctaat aa 972 <210> 31 <211> 927 <212> DNA <213> Homo sapiens <400> 31 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg gtggttctgg cggcggctcc aacatggcta tggcccctgc cctgcagccc 420 acccagggtg ccatgccggc cttcgcctct gctttccagc gccgggcagg aggggtcctg 480 gttgctagcc atctgcagag cttcctggag gtgtcgtacc gcgttctacg ccaccttgcg 540 cagcccacac cattgggccc tgccagctcc ctgccccaga gcttcctgct caagtcttta 600 gagcaagtga gaaagatcca gggcgatggc gcagcgctcc aggagaagct gtgtgccacc 660 tacaagctgt gccaccccga ggagctggtg ctgctcggac actctctggg catcccctgg 720 gctcccctga gctcctgccc cagccaggcc ctgcagctgg caggctgctt gagccaactc 780 catagcggcc ttttcctcta ccaggggctc ctgcaggccc tggaagggat atcccccgag 840 ttgggtccca ccttggacac actgcagctg gacgtcgccg actttgccac caccatctgg 900 cagcagatgg aagaactggg ataataa 927 <210> 32 <211> 972 <212> DNA <213> Homo sapiens <400> 32 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggctatggcc cctgccctgc agcccaccca gggtgccatg 480 ccggccttcg cctctgcttt ccagcgccgg gcaggagggg tcctggttgc tagccatctg 540 cagagcttcc tggaggtgtc gtaccgcgtt ctacgccacc ttgcgcagcc cacaccattg 600 ggccctgcca gctccctgcc ccagagcttc ctgctcaagt ctttagagca agtgagaaag 660 atccagggcg atggcgcagc gctccaggag aagctgtgtg ccacctacaa gctgtgccac 720 cccgaggagc tggtgctgct cggacactct ctgggcatcc cctgggctcc cctgagctcc 780 tgccccagcc aggccctgca gctggcaggc tgcttgagcc aactccatag cggccttttc 840 ctctaccagg ggctcctgca ggccctggaa gggatatccc ccgagttggg tcccaccttg 900 gacacactgc agctggacgt cgccgacttt gccaccacca tctggcagca gatggaagaa 960 ctgggataat aa 972 <210> 33 <211> 927 <212> DNA <213> Homo sapiens <400> 33 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg gtggttctgg cggcggctcc aacatggcta cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agcccacacc attgggccct 540 gccagctccc tgccccagag cttcctgctc aagtctttag agcaagtgag aaagatccag 600 ggcgatggcg cagcgctcca ggagaagctg tgtgccacct acaagctgtg ccaccccgag 660 gagctggtgc tgctcggaca ctctctgggc atcccctggg ctcccctgag ctcctgcccc 720 agccaggccc tgcagctggc aggctgcttg agccaactcc atagcggcct tttcctctac 780 caggggctcc tgcaggccct ggaagggata tcccccgagt tgggtcccac cttggacaca 840 ctgcagctgg acgtcgccga ctttgccacc accatctggc agcagatgga agaactggga 900 atggcccctg ccctgcagcc ctaataa 927 <210> 34 <211> 972 <212> DNA <213> Homo sapiens <400> 34 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggctacccag ggtgccatgc cggccttcgc ctctgctttc 480 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 540 taccgcgttc tacgccacct tgcgcagccc acaccattgg gccctgccag ctccctgccc 600 cagagcttcc tgctcaagtc tttagagcaa gtgagaaaga tccagggcga tggcgcagcg 660 ctccaggaga agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc 720 ggacactctc tgggcatccc ctgggctccc ctgagctcct gccccagcca ggccctgcag 780 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag 840 gccctggaag ggatatcccc cgagttgggt cccaccttgg acacactgca gctggacgtc 900 gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg 960 cagccctaat aa 972 <210> 35 <211> 927 <212> DNA <213> Homo sapiens <400> 35 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg gtggttctgg cggcggctcc aacatggctt ctgctttcca gcgccgggca 420 ggaggggtcc tggttgctag ccatctgcag agcttcctgg aggtgtcgta ccgcgttcta 480 cgccaccttg cgcagcccac accattgggc cctgccagct ccctgcccca gagcttcctg 540 ctcaagtctt tagagcaagt gagaaagatc cagggcgatg gcgcagcgct ccaggagaag 600 ctgtgtgcca cctacaagct gtgccacccc gaggagctgg tgctgctcgg acactctctg 660 ggcatcccct gggctcccct gagctcctgc cccagccagg ccctgcagct ggcaggctgc 720 ttgagccaac tccatagcgg ccttttcctc taccaggggc tcctgcaggc cctggaaggg 780 atatcccccg agttgggtcc caccttggac acactgcagc tggacgtcgc cgactttgcc 840 accaccatct ggcagcagat ggaagaactg ggaatggccc ctgccctgca gcccacccag 900 ggtgccatgc cggccttcgc ctaataa 927 <210> 36 <211> 972 <212> DNA <213> Homo sapiens <400> 36 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggaccgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggcttctgct ttccagcgcc gggcaggagg ggtcctggtt 480 gctagccatc tgcagagctt cctggaggtg tcgtaccgcg ttctacgcca ccttgcgcag 540 cccacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 600 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 660 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 720 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 780 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 840 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 900 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 960 ttcgcctaat aa 972 <210> 37 <211> 963 <212> DNA <213> Homo sapiens <400> 37 atggctaact gctctaacat gatcgatgaa atcatcaccc acctgaagca gccaccgctg 60 ccgctgctgg acttcaacaa cctcaatggt gaagaccaag atatcctaat ggacaataac 120 cttcgtcgtc caaacctcga ggcattcaac cgtgctgtca agtctctgca gaatgcatca 180 gcaattgaga gcattcttaa aaatctcctg ccatgtctgc cgctagccac ggccgcaccc 240 acgcgacatc caatccatat caaggacggt gactggaatg aattccgtcg taaactgacc 300 ttctatctga aaaccttgga gaacgcgcag gctcaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggctacccag ggtgccatgc cggccttcgc ctctgctttc 480 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 540 taccgcgttc tacgccacct tgcgcagccc tctggcggct ctggcggctc tcagagcttc 600 ctgctcaagt ctttagagca agtgagaaag atccagggcg atggcgcagc gctccaggag 660 aagctgtgtg ccacctacaa gctgtgccac cccgaggagc tggtgctgct cggacactct 720 ctgggcatcc cctgggctcc cctgagctcc tgccccagcc aggccctgca gctggcaggc 780 tgcttgagcc aactccatag cggccttttc ctctaccagg ggctcctgca ggccctggaa 840 gggatatccc ccgagttggg tcccaccttg gacacactgc agctggacgt cgccgacttt 900 gccaccacca tctggcagca gatggaagaa ctgggaatgg cccctgccct gcagccctaa 960 taa 963 <210> 38 <211> 972 <212> DNA <213> Homo sapiens <400> 38 atggctaact gctctaacat gatcgatgaa atcatcaccc acctgaagca gccaccgctg 60 ccgctgctgg acttcaacaa cctcaatggt gaagaccaag atatcctgat ggaaaataac 120 cttcgtcgtc caaacctcga ggcattcaac cgtgctgtca agtctctgca gaatgcatca 180 gcaattgaga gcattcttaa aaatctcctg ccatgtctgc ccctggccac ggccgcaccc 240 acgcgacatc caatcatcat ccgtgacggt gactggaatg aattccgtcg taaactgacc 300 ttctatctga aaaccttgga gaacgcgcag gctcaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggctacccag ggtgccatgc cggccttcgc ctctgctttc 480 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 540 taccgcgttc tacgccacct tgcgcagccc acaccattgg gccctgccag ctccctgccc 600 cagagcttcc tgctcaagtc tttagagcaa gtgagaaaga tccagggcga tggcgcagcg 660 ctccaggaga agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc 720 ggacactctc tgggcatccc ctgggctccc ctgagctcct gccccagcca ggccctgcag 780 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag 840 gccctggaag ggatatcccc cgagttgggt cccaccttgg acacactgca gctggacgtc 900 gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg 960 cagccctaat aa 972 <210> 39 <211> 963 <212> DNA <213> Homo sapiens <400> 39 atggctaact gctctaacat gatcgatgaa atcatcaccc acctgaagca gccaccgctg 60 ccgctgctgg acttcaacaa cctcaatggt gaagaccaag atatcctgat ggaaaataac 120 cttcgtcgtc caaacctcga ggcattcaac cgtgctgtca agtctctgca gaatgcatca 180 gcaattgaga gcattcttaa aaatctcctg ccatgtctgc ccctggccac ggccgcaccc 240 acgcgacatc caatcatcat ccgtgacggt gactggaatg aattccgtcg taaactgacc 300 ttctatctga aaaccttgga gaacgcgcag gctcaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat ggctacccag ggtgccatgc cggccttcgc ctctgctttc 480 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 540 taccgcgttc tacgccacct tgcgcagccc tctggcggct ctggcggctc tcagagcttc 600 ctgctcaagt ctttagagca agtgagaaag atccagggcg atggcgcagc gctccaggag 660 aagctgtgtg ccacctacaa gctgtgccac cccgaggagc tggtgctgct cggacactct 720 ctgggcatcc cctgggctcc cctgagctcc tgccccagcc aggccctgca gctggcaggc 780 tgcttgagcc aactccatag cggccttttc ctctaccagg ggctcctgca ggccctggaa 840 gggatatccc ccgagttggg tcccaccttg gacacactgc agctggacgt cgccgacttt 900 gccaccacca tctggcagca gatggaagaa ctgggaatgg cccctgccct gcagccctaa 960 taa 963 <210> 40 <211> 970 <212> DNA <213> Homo sapiens <400> 40 atggctaact gctctaacat gatcgatgaa atcatcaccc acctgaagca gccaccgctg 60 ccgctgctgg acttcaacaa cctcaatggt gaagaccaag atatcctaat ggacaataac 120 cttcgtcgtc caaacctcga ggcattcaac cgtgctgtca agtctctgca gaatgcatca 180 gcaattgaga gcattcttaa aaatctcctg ccatgtctgc cgctagccac ggccgcaccc 240 gcgacatcca atccatatca aggacggtga ctggaatgaa ttccgtcgta aactgacctt 300 ctatctgaaa accttggaga acgcgcaggc tcaacagtac gtagagggcg gtggaggctc 360 cccgggtgaa ccgtctggtc caatctctac tatcaacccg tctcctccgt ctaaagaatc 420 tcataaatct ccaaacatgg ctacccaggg tgccatgccg gccttcgcct ctgctttcca 480 gcgccgggca ggaggggtcc tggttgctag ccatctgcag agcttcctgg aggtgtcgta 540 ccgcgttcta cgccaccttg cgcagcccac accattgggc cctgccagct ccctgcccca 600 gagcttcctg ctcaagtctt tagagcaagt gagaaagatc cagggcgatg gcgcagcgct 660 ccaggagaag ctgtgtgcca cctacaagct gtgccacccc gaggagctgg tgctgctcgg 720 acactctctg ggcatcccct gggctcccct gagctcctgc cccagccagg ccctgcagct 780 ggcaggctgc ttgagccaac tccatagcgg ccttttcctc taccaggggc tcctgcaggc 840 cctggaaggg atatcccccg agttgggtcc caccttggac acactgcagc tggacgtcgc 900 cgactttgcc accaccatct ggcagcagat ggaagaactg ggaatggccc ctgccctgca 960 gccctaataa 970 <210> 41 <211> 918 <212> DNA <213> Homo sapiens <400> 41 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgga ggttcaccct ttgcctacac ctgtcctgct gcctgctgtg 480 gactttagct tgggagaatg gaaaacccag atggaggaga ccaaggcaca ggacattctg 540 ggagcagtga cccttctgct ggagggagtg atggcagcac ggggacaact gggacccact 600 tgcctctcat ccctcctggg gcagctttct ggacaggtcc gtctcctcct tggggccctg 660 cagagcctcc ttggaaccca gcttcctcca cagggcagga ccacagctca caaggatccc 720 aatgccatct tcctgagctt ccaacacctg ctccgaggaa aggtgcgttt cctgatgctt 780 gtaggagggt ccaccctctg cgtcagggaa ttcggcggca acatggcgtc tcccgctccg 840 cctgcttgtg acctccgagt cctcagtaaa ctgcttcgtg actcccatgt ccttcacagc 900 agactgagcc agtgccca 918 <210> 42 <211> 918 <212> DNA <213> Homo sapiens <400> 42 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgtt gcctacacct gtcctgctgc ctgctgtgga ctttagcttg 480 ggagaatgga aaacccagat ggaggagacc aaggcacagg acattctggg agcagtgacc 540 cttctgctgg agggagtgat ggcagcacgg ggacaactgg gacccacttg cctctcatcc 600 ctcctggggc agctttctgg acaggtccgt ctcctccttg gggccctgca gagcctcctt 660 ggaacccagc ttcctccaca gggcaggacc acagctcaca aggatcccaa tgccatcttc 720 ctgagcttcc aacacctgct ccgaggaaag gtgcgtttcc tgatgcttgt aggagggtcc 780 accctctgcg tcagggaatt cggcggcaac atggcgtctc ccgctccgcc tgcttgtgac 840 ctccgagtcc tcagtaaact gcttcgtgac tcccatgtcc ttcacagcag actgagccag 900 tgcccagagg ttcaccct 918 <210> 43 <211> 918 <212> DNA <213> Homo sapiens <400> 43 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggt cctgctgcct gctgtggact ttagcttggg agaatggaaa 480 acccagatgg aggagaccaa ggcacaggac attctgggag cagtgaccct tctgctggag 540 ggagtgatgg cagcacgggg acaactggga cccacttgcc tctcatccct cctggggcag 600 ctttctggac aggtccgtct cctccttggg gccctgcaga gcctccttgg aacccagctt 660 cctccacagg gcaggaccac agctcacaag gatcccaatg ccatcttcct gagcttccaa 720 cacctgctcc gaggaaaggt gcgtttcctg atgcttgtag gagggtccac cctctgcgtc 780 agggaattcg gcggcaacat ggcgtctccc gctccgcctg cttgtgacct ccgagtcctc 840 agtaaactgc ttcgtgactc ccatgtcctt cacagcagac tgagccagtg cccagaggtt 900 caccctttgc ctacacct 918 <210> 44 <211> 918 <212> DNA <213> Homo sapiens <400> 44 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tgtggacttt agcttgggag aatggaaaac ccagatggag 480 gagaccaagg cacaggacat tctgggagca gtgacccttc tgctggaggg agtgatggca 540 gcacggggac aactgggacc cacttgcctc tcatccctcc tggggcagct ttctggacag 600 gtccgtctcc tccttggggc cctgcagagc ctccttggaa cccagcttcc tccacagggc 660 aggaccacag ctcacaagga tcccaatgcc atcttcctga gcttccaaca cctgctccga 720 ggaaaggtgc gtttcctgat gcttgtagga gggtccaccc tctgcgtcag ggaattcggc 780 ggcaacatgg cgtctcccgc tccgcctgct tgtgacctcc gagtcctcag taaactgctt 840 cgtgactccc atgtccttca cagcagactg agccagtgcc cagaggttca ccctttgcct 900 acacctgtcc tgctgcct 918 <210> 45 <211> 918 <212> DNA <213> Homo sapiens <400> 45 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgga ctttagcttg ggagaatgga aaacccagat ggaggagacc 480 aaggcacagg acattctggg agcagtgacc cttctgctgg agggagtgat ggcagcacgg 540 ggacaactgg gacccacttg cctctcatcc ctcctggggc agctttctgg acaggtccgt 600 ctcctccttg gggccctgca gagcctcctt ggaacccagc ttcctccaca gggcaggacc 660 acagctcaca aggatcccaa tgccatcttc ctgagcttcc aacacctgct ccgaggaaag 720 gtgcgtttcc tgatgcttgt aggagggtcc accctctgcg tcagggaatt cggcggcaac 780 atggcgtctc ccgctccgcc tgcttgtgac ctccgagtcc tcagtaaact gcttcgtgac 840 tcccatgtcc ttcacagcag actgagccag tgcccagagg ttcacccttt gcctacacct 900 gtcctgctgc ctgctgtg 918 <210> 46 <211> 907 <212> DNA <213> Homo sapiens <400> 46 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatcggttac ccttgagcaa gcgcaggaac aacagtacgt agagggcggt ggaggctccc 360 cggggaaccg tctggtccaa tctctactat caacccgtct cctccgtcta aagaatctca 420 taaactccaa acatgggaga atggaaaacc cagatggagg agaccaaggc acaggacatt 480 ctggagcagt gacccttctg ctggagggag tgatggcagc acggggacaa ctgggaccca 540 cttgctctca tccctcctgg ggcagctttc tggacaggtc cgtctcctcc ttggggccct 600 gcaggcctcc ttggaaccca gcttcctcca cagggcagga ccacagctca caaggatccc 660 aatgcatctt cctgagcttc caacacctgc tccgaggaaa ggtgcgtttc ctgatgcttg 720 tagggggtcc accctctgcg tcagggaatt cggcggcaac atggcgtctc ccgctccgcc 780 tgctgtgacc tccgagtcct cagtaaactg cttcgtgact cccatgtcct tcacagcaga 840 ctgaccagtg cccagaggtt caccctttgc ctacacctgt cctgctgcct gctgtggact 900 ttagttg 907 <210> 47 <211> 917 <212> DNA <213> Homo sapiens <400> 47 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggg acccacttgc ctctcatccc tcctggggca gctttctgga 480 caggtccgtc tcctccttgg ggccctgcag agcctccttg gaacccagct tcctccacag 540 ggcaggacca cagctcacaa ggatcccaat gccatcttcc tgagcttcca acacctgctc 600 cgaggaaagg tgcgtttcct gatgcttgta ggagggtcca ccctctgcgt cagggaattc 660 ggcggcaaca tggcgtctcc cgctccgcct gcttgtgacc tccgagtcct cagtaaactg 720 cttcgtgact cccatgtcct tcacagcaga ctgagccagt gcccagaggt tcaccctttg 780 cctacacctg tcctgctgcc tgctgtggac tttagcttgg gagaatggaa aacccagatg 840 gaggagacca aggcacagga cattctggga gcagtgaccc ttctgctgga gggagtgatg 900 gcagcacggg gacaact 917 <210> 48 <211> 918 <212> DNA <213> Homo sapiens <400> 48 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggg aacccagctt cctccacagg gcaggaccac agctcacaag 480 gatcccaatg ccatcttcct gagcttccaa cacctgctcc gaggaaaggt gcgtttcctg 540 atgcttgtag gagggtccac cctctgcgtc agggaattcg gcggcaacat ggcgtctccc 600 gctccgcctg cttgtgacct ccgagtcctc agtaaactgc ttcgtgactc ccatgtcctt 660 cacagcagac tgagccagtg cccagaggtt caccctttgc ctacacctgt cctgctgcct 720 gctgtggact ttagcttggg agaatggaaa acccagatgg aggagaccaa ggcacaggac 780 attctgggag cagtgaccct tctgctggag ggagtgatgg cagcacgggg acaactggga 840 cccacttgcc tctcatccct cctggggcag ctttctggac aggtccgtct cctccttggg 900 gccctgcaga gcctcctt 918 <210> 49 <211> 918 <212> DNA <213> Homo sapiens <400> 49 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggg caggaccaca gctcacaagg atcccaatgc catcttcctg 480 agcttccaac acctgctccg aggaaaggtg cgtttcctga tgcttgtagg agggtccacc 540 ctctgcgtca gggaattcgg cggcaacatg gcgtctcccg ctccgcctgc ttgtgacctc 600 cgagtcctca gtaaactgct tcgtgactcc catgtccttc acagcagact gagccagtgc 660 ccagaggttc accctttgcc tacacctgtc ctgctgcctg ctgtggactt tagcttggga 720 gaatggaaaa cccagatgga ggagaccaag gcacaggaca ttctgggagc agtgaccctt 780 ctgctggagg gagtgatggc agcacgggga caactgggac ccacttgcct ctcatccctc 840 ctggggcagc tttctggaca ggtccgtctc ctccttgggg ccctgcagag cctccttgga 900 acccagcttc ctccacag 918 <210> 50 <211> 918 <212> DNA <213> Homo sapiens <400> 50 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tcacaaggat cccaatgcca tcttcctgag cttccaacac 480 ctgctccgag gaaaggtgcg tttcctgatg cttgtaggag ggtccaccct ctgcgtcagg 540 gaattcggcg gcaacatggc gtctcccgct ccgcctgctt gtgacctccg agtcctcagt 600 aaactgcttc gtgactccca tgtccttcac agcagactga gccagtgccc agaggttcac 660 cctttgccta cacctgtcct gctgcctgct gtggacttta gcttgggaga atggaaaacc 720 cagatggagg agaccaaggc acaggacatt ctgggagcag tgacccttct gctggaggga 780 gtgatggcag cacggggaca actgggaccc acttgcctct catccctcct ggggcagctt 840 tctggacagg tccgtctcct ccttggggcc ctgcagagcc tccttggaac ccagcttcct 900 ccacagggca ggaccaca 918 <210> 51 <211> 918 <212> DNA <213> Homo sapiens <400> 51 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgga tcccaatgcc atcttcctga gcttccaaca cctgctccga 480 ggaaaggtgc gtttcctgat gcttgtagga gggtccaccc tctgcgtcag ggaattcggc 540 ggcaacatgg cgtctcccgc tccgcctgct tgtgacctcc gagtcctcag taaactgctt 600 cgtgactccc atgtccttca cagcagactg agccagtgcc cagaggttca ccctttgcct 660 acacctgtcc tgctgcctgc tgtggacttt agcttgggag aatggaaaac ccagatggag 720 gagaccaagg cacaggacat tctgggagca gtgacccttc tgctggaggg agtgatggca 780 gcacggggac aactgggacc cacttgcctc tcatccctcc tggggcagct ttctggacag 840 gtccgtctcc tccttggggc cctgcagagc ctccttggaa cccagcttcc tccacagggc 900 aggaccacag ctcacaag 918 <210> 52 <211> 918 <212> DNA <213> Homo sapiens <400> 52 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc catcttcctg agcttccaac acctgctccg aggaaaggtg 480 cgtttcctga tgcttgtagg agggtccacc ctctgcgtca gggaattcgg cggcaacatg 540 gcgtctcccg ctccgcctgc ttgtgacctc cgagtcctca gtaaactgct tcgtgactcc 600 catgtccttc acagcagact gagccagtgc ccagaggttc accctttgcc tacacctgtc 660 ctgctgcctg ctgtggactt tagcttggga gaatggaaaa cccagatgga ggagaccaag 720 gcacaggaca ttctgggagc agtgaccctt ctgctggagg gagtgatggc agcacgggga 780 caactgggac ccacttgcct ctcatccctc ctggggcagc tttctggaca ggtccgtctc 840 ctccttgggg ccctgcagag cctccttgga acccagcttc ctccacaggg caggaccaca 900 gctcacaagg atcccaat 918 <210> 53 <211> 915 <212> DNA <213> Homo sapiens <400> 53 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgga ggttcaccct ttgcctacac ctgtcctgct gcctgctgtg 480 gactttagct tgggagaatg gaaaacccag atggaggaga ccaaggcaca ggacattctg 540 ggagcagtga cccttctgct ggagggagtg atggcagcac ggggacaact gggacccact 600 tgcctctcat ccctcctggg gcagctttct ggacaggtcc gtctcctcct tggggccctg 660 cagagcctcc ttggaaccca gcttcctcca cagggcagga ccacagctca caaggatccc 720 aatgccatct tcctgagctt ccaacacctg ctccgaggaa aggtgcgttt cctgatgctt 780 gtaggagggt ccaccctctg cgtcagggaa ttcggcaaca tggcgtctcc cgctccgcct 840 gcttgtgacc tccgagtcct cagtaaactg cttcgtgact cccatgtcct tcacagcaga 900 ctgagccagt gccca 915 <210> 54 <211> 915 <212> DNA <213> Homo sapiens <400> 54 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgtt gcctacacct gtcctgctgc ctgctgtgga ctttagcttg 480 ggagaatgga aaacccagat ggaggagacc aaggcacagg acattctggg agcagtgacc 540 cttctgctgg agggagtgat ggcagcacgg ggacaactgg gacccacttg cctctcatcc 600 ctcctggggc agctttctgg acaggtccgt ctcctccttg gggccctgca gagcctcctt 660 ggaacccagc ttcctccaca gggcaggacc acagctcaca aggatcccaa tgccatcttc 720 ctgagcttcc aacacctgct ccgaggaaag gtgcgtttcc tgatgcttgt aggagggtcc 780 accctctgcg tcagggaatt cggcaacatg gcgtctcccg ctccgcctgc ttgtgacctc 840 cgagtcctca gtaaactgct tcgtgactcc catgtccttc acagcagact gagccagtgc 900 ccagaggttc accct 915 <210> 55 <211> 915 <212> DNA <213> Homo sapiens <400> 55 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggt cctgctgcct gctgtggact ttagcttggg agaatggaaa 480 acccagatgg aggagaccaa ggcacaggac attctgggag cagtgaccct tctgctggag 540 ggagtgatgg cagcacgggg acaactggga cccacttgcc tctcatccct cctggggcag 600 ctttctggac aggtccgtct cctccttggg gccctgcaga gcctccttgg aacccagctt 660 cctccacagg gcaggaccac agctcacaag gatcccaatg ccatcttcct gagcttccaa 720 cacctgctcc gaggaaaggt gcgtttcctg atgcttgtag gagggtccac cctctgcgtc 780 agggaattcg gcaacatggc gtctcccgct ccgcctgctt gtgacctccg agtcctcagt 840 aaactgcttc gtgactccca tgtccttcac agcagactga gccagtgccc agaggttcac 900 cctttgccta cacct 915 <210> 56 <211> 915 <212> DNA <213> Homo sapiens <400> 56 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tgtggacttt agcttgggag aatggaaaac ccagatggag 480 gagaccaagg cacaggacat tctgggagca gtgacccttc tgctggaggg agtgatggca 540 gcacggggac aactgggacc cacttgcctc tcatccctcc tggggcagct ttctggacag 600 gtccgtctcc tccttggggc cctgcagagc ctccttggaa cccagcttcc tccacagggc 660 aggaccacag ctcacaagga tcccaatgcc atcttcctga gcttccaaca cctgctccga 720 ggaaaggtgc gtttcctgat gcttgtagga gggtccaccc tctgcgtcag ggaattcggc 780 aacatggcgt ctcccgctcc gcctgcttgt gacctccgag tcctcagtaa actgcttcgt 840 gactcccatg tccttcacag cagactgagc cagtgcccag aggttcaccc tttgcctaca 900 cctgtcctgc tgcct 915 <210> 57 <211> 915 <212> DNA <213> Homo sapiens <400> 57 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgga ctttagcttg ggagaatgga aaacccagat ggaggagacc 480 aaggcacagg acattctggg agcagtgacc cttctgctgg agggagtgat ggcagcacgg 540 ggacaactgg gacccacttg cctctcatcc ctcctggggc agctttctgg acaggtccgt 600 ctcctccttg gggccctgca gagcctcctt ggaacccagc ttcctccaca gggcaggacc 660 acagctcaca aggatcccaa tgccatcttc ctgagcttcc aacacctgct ccgaggaaag 720 gtgcgtttcc tgatgcttgt aggagggtcc accctctgcg tcagggaatt cggcaacatg 780 gcgtctcccg ctccgcctgc ttgtgacctc cgagtcctca gtaaactgct tcgtgactcc 840 catgtccttc acagcagact gagccagtgc ccagaggttc accctttgcc tacacctgtc 900 ctgctgcctg ctgtg 915 <210> 58 <211> 915 <212> DNA <213> Homo sapiens <400> 58 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggg agaatggaaa acccagatgg aggagaccaa ggcacaggac 480 attctgggag cagtgaccct tctgctggag ggagtgatgg cagcacgggg acaactggga 540 cccacttgcc tctcatccct cctggggcag ctttctggac aggtccgtct cctccttggg 600 gccctgcaga gcctccttgg aacccagctt cctccacagg gcaggaccac agctcacaag 660 gatcccaatg ccatcttcct gagcttccaa cacctgctcc gaggaaaggt gcgtttcctg 720 atgcttgtag gagggtccac cctctgcgtc agggaattcg gcaacatggc gtctcccgct 780 ccgcctgctt gtgacctccg agtcctcagt aaactgcttc gtgactccca tgtccttcac 840 agcagactga gccagtgccc agaggttcac cctttgccta cacctgtcct gctgcctgct 900 gtggacttta gcttg 915 <210> 59 <211> 915 <212> DNA <213> Homo sapiens <400> 59 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggg acccacttgc ctctcatccc tcctggggca gctttctgga 480 caggtccgtc tcctccttgg ggccctgcag agcctccttg gaacccagct tcctccacag 540 ggcaggacca cagctcacaa ggatcccaat gccatcttcc tgagcttcca acacctgctc 600 cgaggaaagg tgcgtttcct gatgcttgta ggagggtcca ccctctgcgt cagggaattc 660 ggcaacatgg cgtctcccgc tccgcctgct tgtgacctcc gagtcctcag taaactgctt 720 cgtgactccc atgtccttca cagcagactg agccagtgcc cagaggttca ccctttgcct 780 acacctgtcc tgctgcctgc tgtggacttt agcttgggag aatggaaaac ccagatggag 840 gagaccaagg cacaggacat tctgggagca gtgacccttc tgctggaggg agtgatggca 900 gcacggggac aactg 915 <210> 60 <211> 915 <212> DNA <213> Homo sapiens <400> 60 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggg aacccagctt cctccacagg gcaggaccac agctcacaag 480 gatcccaatg ccatcttcct gagcttccaa cacctgctcc gaggaaaggt gcgtttcctg 540 atgcttgtag gagggtccac cctctgcgtc agggaattcg gcaacatggc gtctcccgct 600 ccgcctgctt gtgacctccg agtcctcagt aaactgcttc gtgactccca tgtccttcac 660 agcagactga gccagtgccc agaggttcac cctttgccta cacctgtcct gctgcctgct 720 gtggacttta gcttgggaga atggaaaacc cagatggagg agaccaaggc acaggacatt 780 ctgggagcag tgacccttct gctggaggga gtgatggcag cacggggaca actgggaccc 840 acttgcctct catccctcct ggggcagctt tctggacagg tccgtctcct ccttggggcc 900 ctgcagagcc tcctt 915 <210> 61 <211> 915 <212> DNA <213> Homo sapiens <400> 61 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggg caggaccaca gctcacaagg atcccaatgc catcttcctg 480 agcttccaac acctgctccg aggaaaggtg cgtttcctga tgcttgtagg agggtccacc 540 ctctgcgtca gggaattcgg caacatggcg tctcccgctc cgcctgcttg tgacctccga 600 gtcctcagta aactgcttcg tgactcccat gtccttcaca gcagactgag ccagtgccca 660 gaggttcacc ctttgcctac acctgtcctg ctgcctgctg tggactttag cttgggagaa 720 tggaaaaccc agatggagga gaccaaggca caggacattc tgggagcagt gacccttctg 780 ctggagggag tgatggcagc acggggacaa ctgggaccca cttgcctctc atccctcctg 840 gggcagcttt ctggacaggt ccgtctcctc cttggggccc tgcagagcct ccttggaacc 900 cagcttcctc cacag 915 <210> 62 <211> 915 <212> DNA <213> Homo sapiens <400> 62 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tcacaaggat cccaatgcca tcttcctgag cttccaacac 480 ctgctccgag gaaaggtgcg tttcctgatg cttgtaggag ggtccaccct ctgcgtcagg 540 gaattcggca acatggcgtc tcccgctccg cctgcttgtg acctccgagt cctcagtaaa 600 ctgcttcgtg actcccatgt ccttcacagc agactgagcc agtgcccaga ggttcaccct 660 ttgcctacac ctgtcctgct gcctgctgtg gactttagct tgggagaatg gaaaacccag 720 atggaggaga ccaaggcaca ggacattctg ggagcagtga cccttctgct ggagggagtg 780 atggcagcac ggggacaact gggacccact tgcctctcat ccctcctggg gcagctttct 840 ggacaggtcc gtctcctcct tggggccctg cagagcctcc ttggaaccca gcttcctcca 900 cagggcagga ccaca 915 <210> 63 <211> 915 <212> DNA <213> Homo sapiens <400> 63 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgga tcccaatgcc atcttcctga gcttccaaca cctgctccga 480 ggaaaggtgc gtttcctgat gcttgtagga gggtccaccc tctgcgtcag ggaattcggc 540 aacatggcgt ctcccgctcc gcctgcttgt gacctccgag tcctcagtaa actgcttcgt 600 gactcccatg tccttcacag cagactgagc cagtgcccag aggttcaccc tttgcctaca 660 cctgtcctgc tgcctgctgt ggactttagc ttgggagaat ggaaaaccca gatggaggag 720 accaaggcac aggacattct gggagcagtg acccttctgc tggagggagt gatggcagca 780 cggggacaac tgggacccac ttgcctctca tccctcctgg ggcagctttc tggacaggtc 840 cgtctcctcc ttggggccct gcagagcctc cttggaaccc agcttcctcc acagggcagg 900 accacagctc acaag 915 <210> 64 <211> 915 <212> DNA <213> Homo sapiens <400> 64 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc catcttcctg agcttccaac acctgctccg aggaaaggtg 480 cgtttcctga tgcttgtagg agggtccacc ctctgcgtca gggaattcgg caacatggcg 540 tctcccgctc cgcctgcttg tgacctccga gtcctcagta aactgcttcg tgactcccat 600 gtccttcaca gcagactgag ccagtgccca gaggttcacc ctttgcctac acctgtcctg 660 ctgcctgctg tggactttag cttgggagaa tggaaaaccc agatggagga gaccaaggca 720 caggacattc tgggagcagt gacccttctg ctggagggag tgatggcagc acggggacaa 780 ctgggaccca cttgcctctc atccctcctg gggcagcttt ctggacaggt ccgtctcctc 840 cttggggccc tgcagagcct ccttggaacc cagcttcctc cacagggcag gaccacagct 900 cacaaggatc ccaat 915 <210> 65 <211> 921 <212> DNA <213> Homo sapiens <400> 65 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 gacttccaaa cctggagagc ttcgtaaggg ctgtcaagaa cttagaaaat gcatcaggta 180 tgaggcaatt cttcgtaatc tccaaccatg tctgccctct gccacggccg caccctctcg 240 catccaatca tcatcaaggc aggtgactgg caagaattcc gggaaaaact gacgttctat 300 tggttaccct tgagcaagcg caggaacaac agtacgtaga gggcggtgga ggctccccgg 360 taaccgtctg gtccaatctc tactatcaac ccgtctcctc cgtctaaaga atctcataaa 420 tctccaaaca tggaggttca ccctttgcct acacctgtcc tgctgcctgc tgtggacttt 480 agcttgggag aatggaaaac ccagatggag gagaccaagg cacaggacat tctgggagca 540 gtgacccttc tgctggaggg agtgatggca gcacggggac aactgggacc cacttgcctc 600 tcatccctcc tggggcagct ttctggacag gtccgtctcc tccttggggc cctgcagagc 660 ctccttggaa cccagcttcc tccacagggc aggaccacag ctcacaagga tcccaatgcc 720 atcttcctga gcttccaaca cctgctccga ggaaaggtgc gtttcctgat gcttgtagga 780 gggtccaccc tctgcgtcag ggaattcggc ggcaacggcg gcaacatggc gtccccagcg 840 ccgcctgctt gtgacctccg agtcctcagt aaactgcttc gtgactccca tgtccttcac 900 agcagactga gccagtgccc a 921 <210> 66 <211> 927 <212> DNA <213> Homo sapiens <400> 66 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgtt gcctacacct gtcctgctgc ctgctgtgga ctttagcttg 480 ggagaatgga aaacccagat ggaggagacc aaggcacagg acattctggg agcagtgacc 540 cttctgctgg agggagtgat ggcagcacgg ggacaactgg gacccacttg cctctcatcc 600 ctcctggggc agctttctgg acaggtccgt ctcctccttg gggccctgca gagcctcctt 660 ggaacccagc ttcctccaca gggcaggacc acagctcaca aggatcccaa tgccatcttc 720 ctgagcttcc aacacctgct ccgaggaaag gtgcgtttcc tgatgcttgt aggagggtcc 780 accctctgcg tcagggaatt cggcggcaac ggcggcaaca tggcgtcccc agcgccgcct 840 gcttgtgacc tccgagtcct cagtaaactg cttcgtgact cccatgtcct tcacagcaga 900 ctgagccagt gcccagaggt tcaccct 927 <210> 67 <211> 927 <212> DNA <213> Homo sapiens <400> 67 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggt cctgctgcct gctgtggact ttagcttggg agaatggaaa 480 acccagatgg aggagaccaa ggcacaggac attctgggag cagtgaccct tctgctggag 540 ggagtgatgg cagcacgggg acaactggga cccacttgcc tctcatccct cctggggcag 600 ctttctggac aggtccgtct cctccttggg gccctgcaga gcctccttgg aacccagctt 660 cctccacagg gcaggaccac agctcacaag gatcccaatg ccatcttcct gagcttccaa 720 cacctgctcc gaggaaaggt gcgtttcctg atgcttgtag gagggtccac cctctgcgtc 780 agggaattcg gcggcaacgg cggcaacatg gcgtccccag cgccgcctgc ttgtgacctc 840 cgagtcctca gtaaactgct tcgtgactcc catgtccttc acagcagact gagccagtgc 900 ccagaggttc accctttgcc tacacct 927 <210> 68 <211> 927 <212> DNA <213> Homo sapiens <400> 68 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tgtggacttt agcttgggag aatggaaaac ccagatggag 480 gagaccaagg cacaggacat tctgggagca gtgacccttc tgctggaggg agtgatggca 540 gcacggggac aactgggacc cacttgcctc tcatccctcc tggggcagct ttctggacag 600 gtccgtctcc tccttggggc cctgcagagc ctccttggaa cccagcttcc tccacagggc 660 aggaccacag ctcacaagga tcccaatgcc atcttcctga gcttccaaca cctgctccga 720 ggaaaggtgc gtttcctgat gcttgtagga gggtccaccc tctgcgtcag ggaattcggc 780 ggcaacggcg gcaacatggc gtccccagcg ccgcctgctt gtgacctccg agtcctcagt 840 aaactgcttc gtgactccca tgtccttcac agcagactga gccagtgccc agaggttcac 900 cctttgccta cacctgtcct gctgcct 927 <210> 69 <211> 927 <212> DNA <213> Homo sapiens <400> 69 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgga ctttagcttg ggagaatgga aaacccagat ggaggagacc 480 aaggcacagg acattctggg agcagtgacc cttctgctgg agggagtgat ggcagcacgg 540 ggacaactgg gacccacttg cctctcatcc ctcctggggc agctttctgg acaggtccgt 600 ctcctccttg gggccctgca gagcctcctt ggaacccagc ttcctccaca gggcaggacc 660 acagctcaca aggatcccaa tgccatcttc ctgagcttcc aacacctgct ccgaggaaag 720 gtgcgtttcc tgatgcttgt aggagggtcc accctctgcg tcagggaatt cggcggcaac 780 ggcggcaaca tggcgtcccc agcgccgcct gcttgtgacc tccgagtcct cagtaaactg 840 cttcgtgact cccatgtcct tcacagcaga ctgagccagt gcccagaggt tcaccctttg 900 cctacacctg tcctgctgcc tgctgtg 927 <210> 70 <211> 927 <212> DNA <213> Homo sapiens <400> 70 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggg agaatggaaa acccagatgg aggagaccaa ggcacaggac 480 attctgggag cagtgaccct tctgctggag ggagtgatgg cagcacgggg acaactggga 540 cccacttgcc tctcatccct cctggggcag ctttctggac aggtccgtct cctccttggg 600 gccctgcaga gcctccttgg aacccagctt cctccacagg gcaggaccac agctcacaag 660 gatcccaatg ccatcttcct gagcttccaa cacctgctcc gaggaaaggt gcgtttcctg 720 atgcttgtag gagggtccac cctctgcgtc agggaattcg gcggcaacgg cggcaacatg 780 gcgtccccag cgccgcctgc ttgtgacctc cgagtcctca gtaaactgct tcgtgactcc 840 catgtccttc acagcagact gagccagtgc ccagaggttc accctttgcc tacacctgtc 900 ctgctgcctg ctgtggactt tagcttg 927 <210> 71 <211> 927 <212> DNA <213> Homo sapiens <400> 71 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggg acccacttgc ctctcatccc tcctggggca gctttctgga 480 caggtccgtc tcctccttgg ggccctgcag agcctccttg gaacccagct tcctccacag 540 ggcaggacca cagctcacaa ggatcccaat gccatcttcc tgagcttcca acacctgctc 600 cgaggaaagg tgcgtttcct gatgcttgta ggagggtcca ccctctgcgt cagggaattc 660 ggcggcaacg gcggcaacat ggcgtcccca gcgccgcctg cttgtgacct ccgagtcctc 720 agtaaactgc ttcgtgactc ccatgtcctt cacagcagac tgagccagtg cccagaggtt 780 caccctttgc ctacacctgt cctgctgcct gctgtggact ttagcttggg agaatggaaa 840 acccagatgg aggagaccaa ggcacaggac attctgggag cagtgaccct tctgctggag 900 ggagtgatgg cagcacgggg acaactg 927 <210> 72 <211> 927 <212> DNA <213> Homo sapiens <400> 72 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggg aacccagctt cctccacagg gcaggaccac agctcacaag 480 gatcccaatg ccatcttcct gagcttccaa cacctgctcc gaggaaaggt gcgtttcctg 540 atgcttgtag gagggtccac cctctgcgtc agggaattcg gcggcaacgg cggcaacatg 600 gcgtccccag cgccgcctgc ttgtgacctc cgagtcctca gtaaactgct tcgtgactcc 660 catgtccttc acagcagact gagccagtgc ccagaggttc accctttgcc tacacctgtc 720 ctgctgcctg ctgtggactt tagcttggga gaatggaaaa cccagatgga ggagaccaag 780 gcacaggaca ttctgggagc agtgaccctt ctgctggagg gagtgatggc agcacgggga 840 caactgggac ccacttgcct ctcatccctc ctggggcagc tttctggaca ggtccgtctc 900 ctccttgggg ccctgcagag cctcctt 927 <210> 73 <211> 927 <212> DNA <213> Homo sapiens <400> 73 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggg caggaccaca gctcacaagg atcccaatgc catcttcctg 480 agcttccaac acctgctccg aggaaaggtg cgtttcctga tgcttgtagg agggtccacc 540 ctctgcgtca gggaattcgg cggcaacggc ggcaacatgg cgtccccagc gccgcctgct 600 tgtgacctcc gagtcctcag taaactgctt cgtgactccc atgtccttca cagcagactg 660 agccagtgcc cagaggttca ccctttgcct acacctgtcc tgctgcctgc tgtggacttt 720 agcttgggag aatggaaaac ccagatggag gagaccaagg cacaggacat tctgggagca 780 gtgacccttc tgctggaggg agtgatggca gcacggggac aactgggacc cacttgcctc 840 tcatccctcc tggggcagct ttctggacag gtccgtctcc tccttggggc cctgcagagc 900 ctccttggaa cccagcttcc tccacag 927 <210> 74 <211> 927 <212> DNA <213> Homo sapiens <400> 74 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tcacaaggat cccaatgcca tcttcctgag cttccaacac 480 ctgctccgag gaaaggtgcg tttcctgatg cttgtaggag ggtccaccct ctgcgtcagg 540 gaattcggcg gcaacggcgg caacatggcg tccccagcgc cgcctgcttg tgacctccga 600 gtcctcagta aactgcttcg tgactcccat gtccttcaca gcagactgag ccagtgccca 660 gaggttcacc ctttgcctac acctgtcctg ctgcctgctg tggactttag cttgggagaa 720 tggaaaaccc agatggagga gaccaaggca caggacattc tgggagcagt gacccttctg 780 ctggagggag tgatggcagc acggggacaa ctgggaccca cttgcctctc atccctcctg 840 gggcagcttt ctggacaggt ccgtctcctc cttggggccc tgcagagcct ccttggaacc 900 cagcttcctc cacagggcag gaccaca 927 <210> 75 <211> 927 <212> DNA <213> Homo sapiens <400> 75 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgga tcccaatgcc atcttcctga gcttccaaca cctgctccga 480 ggaaaggtgc gtttcctgat gcttgtagga gggtccaccc tctgcgtcag ggaattcggc 540 ggcaacggcg gcaacatggc gtccccagcg ccgcctgctt gtgacctccg agtcctcagt 600 aaactgcttc gtgactccca tgtccttcac agcagactga gccagtgccc agaggttcac 660 cctttgccta cacctgtcct gctgcctgct gtggacttta gcttgggaga atggaaaacc 720 cagatggagg agaccaaggc acaggacatt ctgggagcag tgacccttct gctggaggga 780 gtgatggcag cacggggaca actgggaccc acttgcctct catccctcct ggggcagctt 840 tctggacagg tccgtctcct ccttggggcc ctgcagagcc tccttggaac ccagcttcct 900 ccacagggca ggaccacagc tcacaag 927 <210> 76 <211> 927 <212> DNA <213> Homo sapiens <400> 76 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc catcttcctg agcttccaac acctgctccg aggaaaggtg 480 cgtttcctga tgcttgtagg agggtccacc ctctgcgtca gggaattcgg cggcaacggc 540 ggcaacatgg cgtccccagc gccgcctgct tgtgacctcc gagtcctcag taaactgctt 600 cgtgactccc atgtccttca cagcagactg agccagtgcc cagaggttca ccctttgcct 660 acacctgtcc tgctgcctgc tgtggacttt agcttgggag aatggaaaac ccagatggag 720 gagaccaagg cacaggacat tctgggagca gtgacccttc tgctggaggg agtgatggca 780 gcacggggac aactgggacc cacttgcctc tcatccctcc tggggcagct ttctggacag 840 gtccgtctcc tccttggggc cctgcagagc ctccttggaa cccagcttcc tccacagggc 900 aggaccacag ctcacaagga tcccaat 927 <210> 77 <211> 906 <212> DNA <213> Homo sapiens <400> 77 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatgga tcccaatgcc atcttcctga gcttccaaca cctgctccga 480 ggaaaggtgc gtttcctgat gcttgtagga gggtccaccc tctgcgtcag ggaattcggc 540 ggcaacatgg cgtctcccgc tccgcctgct tgtgacctcc gagtcctcag taaactgctt 600 cgtgactccc atgtccttca cagcagactg agccagtgcc cagaggttca ccctttgcct 660 acacctgtcc tgctgcctgc tgtggacttt agcttgggag aatggaaaac ccagatggag 720 gagaccaagg cacaggacat tctgggagca gtgacccttc tgctggaggg agtgatggca 780 gcacggggac aactgggacc cacttgcctc tcatccctcc tggggcagct ttctggacag 840 gtccgtctcc tccttggggc cctgcagagc ctccttggaa cccagggcag gaccacagct 900 cacaag 906 <210> 78 <211> 993 <212> DNA <213> Homo sapiens <400> 78 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggatcgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat gtcttacaag ctgtgccacc ccgaggagct ggtgctgctc 480 ggacactctc tgggcatccc ctgggctccc ctgagctcct gccccagcca ggccctgcag 540 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag 600 gccctggaag ggatatcccc cgagttgggt cccaccttgg acacactgca gctggacgtc 660 gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg 720 cagcccaccc agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg 780 gtcctggttg ctagccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac 840 cttgcgcagc ccggcggcgg ctctgacatg gctacaccat taggccctgc cagctccctg 900 ccccagagct tcctgctcaa gtctttagag caagtgagga agatccaggg cgatggcgca 960 gcgctccagg agaagctgtg tgccacctaa taa 993 <210> 79 <211> 993 <212> DNA <213> Homo sapiens <400> 79 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggatcgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat gtctcccgag ttgggtccca ccttggacac actgcagctg 480 gacgtcgccg actttgccac caccatctgg cagcagatgg aagaactggg aatggcccct 540 gccctgcagc ccacccaggg tgccatgccg gccttcgcct ctgctttcca gcgccgggca 600 ggaggggtcc tggttgctag ccatctgcag agcttcctgg aggtgtcgta ccgcgttcta 660 cgccaccttg cgcagcccgg cggcggctct gacatggcta caccattagg ccctgccagc 720 tccctgcccc agagcttcct gctcaagtct ttagagcaag tgaggaagat ccagggcgat 780 ggcgcagcgc tccaggagaa gctgtgtgcc acctacaagc tgtgccaccc cgaggagctg 840 gtgctgctcg gacactctct gggcatcccc tgggctcccc tgagctcctg ccccagccag 900 gccctgcagc tggcaggctg cttgagccaa ctccatagcg gccttttcct ctaccagggg 960 ctcctgcagg ccctggaagg gatatcctaa taa 993 <210> 80 <211> 993 <212> DNA <213> Homo sapiens <400> 80 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggatcgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat gtcttctgct ttccagcgcc gggcaggagg ggtcctggtt 480 gctagccatc tgcagagctt cctggaggtg tcgtaccgcg ttctacgcca ccttgcgcag 540 cccggcggcg gctctgacat ggctacacca ttaggccctg ccagctccct gccccagagc 600 ttcctgctca agtctttaga gcaagtgagg aagatccagg gcgatggcgc agcgctccag 660 gagaagctgt gtgccaccta caagctgtgc caccccgagg agctggtgct gctcggacac 720 tctctgggca tcccctgggc tcccctgagc tcctgcccca gccaggccct gcagctggca 780 ggctgcttga gccaactcca tagcggcctt ttcctctacc aggggctcct gcaggccctg 840 gaagggatat cccccgagtt gggtcccacc ttggacacac tgcagctgga cgtcgccgac 900 tttgccacca ccatctggca gcagatggaa gaactgggaa tggcccctgc cctgcagccc 960 acccagggtg ccatgccggc cttcgcctaa taa 993 <210> 81 <211> 993 <212> DNA <213> Homo sapiens <400> 81 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggatcgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat gtctatggcc cctgccctgc agcccaccca gggtgccatg 480 ccggccttcg cctctgcttt ccagcgccgg gcaggagggg tcctggttgc tagccatctg 540 cagagcttcc tggaggtgtc gtaccgcgtt ctacgccacc ttgcgcagcc cggcggcggc 600 tctgacatgg ctacaccatt aggccctgcc agctccctgc cccagagctt cctgctcaag 660 tctttagagc aagtgaggaa gatccagggc gatggcgcag cgctccagga gaagctgtgt 720 gccacctaca agctgtgcca ccccgaggag ctggtgctgc tcggacactc tctgggcatc 780 ccctgggctc ccctgagctc ctgccccagc caggccctgc agctggcagg ctgcttgagc 840 caactccata gcggcctttt cctctaccag gggctcctgc aggccctgga agggatatcc 900 cccgagttgg gtcccacctt ggacacactg cagctggacg tcgccgactt tgccaccacc 960 atctggcagc agatggaaga actgggataa taa 993 <210> 82 <211> 993 <212> DNA <213> Homo sapiens <400> 82 atggctaact gctctataat gatcgatgaa attatacatc acttaaagag accacctgca 60 cctttgctgg acccgaacaa cctcaatgac gaagacgtct ctatcctgat ggatcgaaac 120 cttcgacttc caaacctgga gagcttcgta agggctgtca agaacttaga aaatgcatca 180 ggtattgagg caattcttcg taatctccaa ccatgtctgc cctctgccac ggccgcaccc 240 tctcgacatc caatcatcat caaggcaggt gactggcaag aattccggga aaaactgacg 300 ttctatctgg ttacccttga gcaagcgcag gaacaacagt acgtagaggg cggtggaggc 360 tccccgggtg aaccgtctgg tccaatctct actatcaacc cgtctcctcc gtctaaagaa 420 tctcataaat ctccaaacat gtctacccag ggtgccatgc cggccttcgc ctctgctttc 480 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 540 taccgcgttc tacgccacct tgcgcagccc ggcggcggct ctgacatggc tacaccatta 600 ggccctgcca gctccctgcc ccagagcttc ctgctcaagt ctttagagca agtgaggaag 660 atccagggcg atggcgcagc gctccaggag aagctgtgtg ccacctacaa gctgtgccac 720 cccgaggagc tggtgctgct cggacactct ctgggcatcc cctgggctcc cctgagctcc 780 tgccccagcc aggccctgca gctggcaggc tgcttgagcc aactccatag cggccttttc 840 ctctaccagg ggctcctgca ggccctggaa gggatatccc ccgagttggg tcccaccttg 900 gacacactgc agctggacgt cgccgacttt gccaccacca tctggcagca gatggaagaa 960 ctgggaatgg cccctgccct gcagccctaa taa 993 <210> 83 <211> 1027 <212> DNA <213> Homo sapiens <400> 83 atggctacac cattgggccc tgccagctcc ctgccccaga gcttcctgct caagtcttta 60 gagcaagtga ggaagatcca gggcgatggc gcagcgctcc aggagaagct gtgtgccacc 120 tacaagctgt gccaccccga ggagctggtg ctgctcggac actctctggg catcccctgg 180 gctcccctga gctcctgccc cagccaggcc ctgcagctgg caggctgctt gagccaactc 240 catagcggcc ttttcctcta ccaggggctc ctgcaggccc tggaagggat atcccccgag 300 ttgggtccca ccttggacac actgcagctg gacgtcgccg actttgccac caccatctgg 360 cagcagatgg aagaactggg aatggcccct gccctgcagc ccacccaggg tgccatgccg 420 gccttcgcct ctgctttcca gcgccgggca ggaggggtcc tggttgctag ccatctgcag 480 agcttcctgg aggtgtcgta ccgcgttcta cgccaccttg cgcagcccgg cggcggctct 540 gacatggcta caccattggg ccctgccagc tccctgcccc agagcttcct gctcaagtct 600 ttagagcaag tgaggaagat ccagggcgat ggcgcagcgc tccaggagaa gctgtgtgcc 660 acctacaagc tgtgccaccc cgaggagctg gtgctgctcg gacactctct gggcatcccc 720 tgggctcccc tgagctcctg ccccagccag gccctgcagc tggcaggctg cttgagccaa 780 ctccatagcg gccttttcct ctaccagggg ctcctgcagg ccctggaagg gatatccccc 840 gagttgggtc ccaccttgga cacactgcag ctggacgtcg ccgactttgc caccaccatc 900 tggcagcaga tggaagaact gggaatggcc cctgccctgc agcccaccca tcctggttgc 960 tagccatctg cagagcttcc tggaggtgtc gtaccgcgtt ctacgccacc ttgcgcagcc 1020 ctgataa 1027 <210> 84 <211> 459 <212> DNA <213> Homo sapiens <400> 84 tctcccgctc cgcctgcttg tgacctccga gtcctcagta aactgcttcg tgactcccat 60 gtccttcaca gcagactgag ccagtgccca gaggttcacc ctttgcctac acctgtcctg 120 ctgcctgctg tggactttag cttgggagaa tggaaaaccc agatggagga gaccaaggca 180 caggacattc tgggagcagt gacccttctg ctggagggag tgatggcagc acggggacaa 240 ctgggaccca cttgcctctc atccctcctg gggcagcttt ctggacaggt ccgtctcctc 300 cttggggccc tgcagagcct ccttggaacc cagcttcctc cacagggcag gaccacagct 360 cacaaggatc ccaatgccat cttcctgagc ttccaacacc tgctccgagg aaaggtgcgt 420 ttcctgatgc ttgtaggagg gtccaccctc tgcgtcagg 459 <210> 85 <211> 447 <212> DNA <213> Homo sapiens <400> 85 tctcccgctc cgcctgcttg tgacctccga gtcctcagta aactgcttcg tgactcccat 60 gtccttcaca gcagactgag ccagtgccca gaggttcacc ctttgcctac acctgtcctg 120 ctgcctgctg tggactttag cttgggagaa tggaaaaccc agatggagga gaccaaggca 180 caggacattc tgggagcagt gacccttctg ctggagggag tgatggcagc acggggacaa 240 ctgggaccca cttgcctctc atccctcctg gggcagcttt ctggacaggt ccgtctcctc 300 cttggggccc tgcagagcct ccttggaacc cagggcagga ccacagctca caaggatccc 360 aatgccatct tcctgagctt ccaacacctg ctccgaggaa aggtgcgttt cctgatgctt 420 gtaggagggt ccaccctctg cgtcagg 447 <210> 86 <211> 459 <212> DNA <213> Homo sapiens <400> 86 tccccagcgc cgcctgcttg tgacctccga gtcctcagta aactgcttcg tgactcccat 60 gtccttcaca gcagactgag ccagtgccca gaggttcacc ctttgcctac acctgtcctg 120 ctgcctgctg tggactttag cttgggagaa tggaaaaccc agatggagga gaccaaggca 180 caggacattc tgggagcagt gacccttctg ctggagggag tgatggcagc acggggacaa 240 ctgggaccca cttgcctctc atccctcctg gggcagcttt ctggacaggt ccgtctcctc 300 cttggggccc tgcagagcct ccttggaacc cagcttcctc cacagggcag gaccacagct 360 cacaaggatc ccaatgccat cttcctgagc ttccaacacc tgctccgagg aaaggtgcgt 420 ttcctgatgc ttgtaggagg gtccaccctc tgcgtcagg 459 <210> 87 <211> 464 <212> DNA <213> Homo sapiens <400> 87 ccatggctaa ctgctctata atgatcgatg aaattataca tcacttaaag agaccacctg 60 cacctttgct ggacccgaac aacctcaatg acgaagacgt ctctatcctg atggatcgaa 120 accttcgact tccaaacctg gagagcttcg taagggctgt caagaactta gaaaatgcat 180 caggtattga ggcaattctt cgtaatctcc aaccatgtct gccctctgcc acggccgcac 240 cctctcgaca tccaatcatc atcaaggcag gtgactggca agaattccgg gaaaaactga 300 cgttctatct ggttaccctt gagcaagcgc aggaacaaca gtacgtagag ggcggtggag 360 gctccccggg tgaaccgtct ggtccaatct ctactatcaa cccgtctcct ccgtctaaag 420 aatctcataa atctccaaac atgtaaggta ccgcatgcaa gctt 464 <210> 88 <211> 419 <212> DNA <213> Homo sapiens <400> 88 ccatggctaa ctgctctata atgatcgatg aaattataca tcacttaaag agaccacctg 60 cacctttgct ggacccgaac aacctcaatg acgaagacgt ctctatcctg atggatcgaa 120 accttcgact tccaaacctg gagagcttcg taagggctgt caagaactta gaaaatgcat 180 caggtattga ggcaattctt cgtaatctcc aaccatgtct gccctctgcc acggccgcac 240 cctctcgaca tccaatcatc atcaaggcag gtgactggca agaattccgg gaaaaactga 300 cgttctatct ggttaccctt gagcaagcgc aggaacaaca gtacgtagag ggcggtggag 360 gctccccggg tggtggttct ggcggcggct ccaacatgta aggtaccgca tgcaagctt 419 <210> 89 <211> 405 <212> DNA <213> Homo sapiens <400> 89 gccacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggc gctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agccc 405 <210> 90 <211> 420 <212> DNA <213> Homo sapiens <400> 90 gccacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 420 420 <210> 91 <211> 366 <212> DNA <213> Homo sapiens <400> 91 gccacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcaggag acctccgagc agctggtggc gctgaagccc 300 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 360 accctg 366 <210> 92 <211> 405 <212> DNA <213> Homo sapiens <400> 92 ggaactcagg attgttcttt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agccc 405 <210> 93 <211> 420 <212> DNA <213> Homo sapiens <400> 93 ggtacccagg attgttcttt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 420 420 <210> 94 <211> 405 <212> DNA <213> Homo sapiens <400> 94 gccactcagg actgttcttt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agccc 405 <210> 95 <211> 420 <212> DNA <213> Homo sapiens <400> 95 gccactcagg actgctcttt tcaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 420 420 <210> 96 <211> 465 <212> DNA <213> Homo sapiens <400> 96 gccgacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgtctggag gtaacggatc cggtggcaat gggagcggcg gaaatggaac ccaggactgc 360 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 420 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgcag 465 <210> 97 <211> 450 <212> DNA <213> Homo sapiens <400> 97 gccgacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgtcaggcg gtaacggcag tggaggtaat ggcacccagg actgctcctt ccaacacagc 360 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 420 tacccagtca ccgtggcctc caacctgcag 450 <210> 98 <211> 435 <212> DNA <213> Homo sapiens <400> 98 gccgacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgtctggcg gcaacggcac ccaggactgc tccttccaac acagccccat ctcctccgac 360 ttcgctgtca aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg 420 gcctccaacc tgcag 435 <210> 99 <211> 465 <212> DNA <213> Homo sapiens <400> 99 gcctccaaga tgcaaggctt gctggagcgc gtgaacacgg agatacactt tgtcaccaaa 60 tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc agaccaacat ctcccgcctc 120 ctgcaggaga cctccgagca gctggtggcg ctgaagccct ggatcactcg ccagaacttc 180 tcccggtgcc tggagctgca gtgtcagccc gactcctcaa ccctgtctgg aggtaacgga 240 tccggtggca atgggagcgg cggaaatgga acccaggact gctccttcca acacagcccc 300 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 360 ccagtcaccg tggcctccaa cctgcaggac gaggagctct gcgggggcct ctggcggctg 420 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctggg 465 <210> 100 <211> 450 <212> DNA <213> Homo sapiens <400> 100 gcctccaaga tgcaaggctt gctggagcgc gtgaacacgg agatacactt tgtcaccaaa 60 tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc agaccaacat ctcccgcctc 120 ctgcaggaga cctccgagca gctggtggcg ctgaagccct ggatcactcg ccagaacttc 180 tcccggtgcc tggagctgca gtgtcagccc gactcctcaa ccctgtctgg aggtaacgga 240 tccggaggta atggcaccca ggactgctcc ttccaacaca gccccatctc ctccgacttc 300 gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag attacccagt caccgtggcc 360 tccaacctgc aggacgagga gctctgcggg ggcctctggc ggctggtcct ggcacagcgc 420 tggatggagc ggctcaagac tgtcgctggg 450 <210> 101 <211> 435 <212> DNA <213> Homo sapiens <400> 101 gcctccaaga tgcaaggctt gctggagcgc gtgaacacgg agatacactt tgtcaccaaa 60 tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc agaccaacat ctcccgcctc 120 ctgcaggaga cctccgagca gctggtggcg ctgaagccct ggatcactcg ccagaacttc 180 tcccggtgcc tggagctgca gtgtcagccc gactcctcaa ccctgtctgg cggcaacggc 240 acgcaggact gctccttcca acacagcccc atctcctccg acttcgctgt caaaatccgt 300 gagctgtctg actacctgct tcaagattac ccagtcaccg tggcctccaa cctgcaggac 360 gaggagctct gcgggggcct ctggcggctg gtcctggcac agcgctggat ggagcggctc 420 aagactgtcg ctggg 435 <210> 102 <211> 465 <212> DNA <213> Homo sapiens <400> 102 gcccccccca gctgtcttcg cttcgtccag accaacatct cccgcctcct gcaggagacc 60 tccgagcagc tggtggcgct gaagccctgg atcactcgcc agaacttctc ccggtgcctg 120 gagctgcagt gtcagcccga ctcctcaacc ctgtctggag gtaacggcag tggtggcaat 180 gggagcggtg gaaatggaac ccaggactgc tccttccaac acagccccat ctcctccgac 240 ttcgctgtca aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg 300 gcctccaacc tgcaggacga ggagctctgc gggggcctct ggcggctggt cctggcacag 360 cgctggatgg agcggctcaa gactgtcgct gggtccaaga tgcaaggctt gctggagcgc 420 gtgaacacgg agatacactt tgtcaccaaa tgtgcctttc agccc 465 <210> 103 <211> 450 <212> DNA <213> Homo sapiens <400> 103 gcccccccca gctgtcttcg cttcgtccag accaacatct cccgcctcct gcaggagacc 60 tccgagcagc tggtggcgct gaagccctgg atcactcgcc agaacttctc ccggtgcctg 120 gagctgcagt gtcagcccga ctcctcaacc ctgtcaggcg gtaacggcag tggaggtaat 180 ggcacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 240 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 300 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 360 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 420 cactttgtca ccaaatgtgc ctttcagccc 450 <210> 104 <211> 435 <212> DNA <213> Homo sapiens <400> 104 gcccccccca gctgtcttcg cttcgtccag accaacatct cccgcctcct gcaggagacc 60 tccgagcagc tggtggcgct gaagccctgg atcactcgcc agaacttctc ccggtgcctg 120 gagctgcagt gtcagcccga ctcctcaacc ctgtctggcg gcaacggcac gcaggactgc 180 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 240 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgcaggacga ggagctctgc 300 gggggcctct ggcggctggt cctggcacag cgctggatgg agcggctcaa gactgtcgct 360 gggtccaaga tgcaaggctt gctggagcgc gtgaacacgg agatacactt tgtcaccaaa 420 tgtgcctttc agccc 435 <210> 105 <211> 451 <212> DNA <213> Homo sapiens <400> 105 gccgacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgtctggag gtagtggatc cggaggttct ggcaacccag gactgctcct tccaacacag 360 ccccatctcc tccgacttcg ctgtcaaaat ccgtgagctg tctgactacc tgcttcaaga 420 ttacccagtc accgtggcct ccaacctgca g 451 <210> 106 <211> 465 <212> DNA <213> Homo sapiens <400> 106 gccgacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgtctggag gtagtggatc cggtggcagt gggagcggcg gatctggaac ccaggactgc 360 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 420 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgcag 465 <210> 107 <211> 437 <212> DNA <213> Homo sapiens <400> 107 ccatggccac ccaggactgc tccttccaac acagccccat ctcctccgac ttcgctgtca 60 aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg gcctccaacc 120 tgcaggacga ggagctctgc gggggcctct ggcggctggt cctggcacag cgctggatgg 180 agcggctcaa gactgtcgct gggtccaaga tgcaaggctt gctggagcgc gtgaacacgg 240 agatacactt tgtcaccaaa tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc 300 agaccaacat ctcccgcctc ctgcaggaga cctccgagca gctggtggcg ctgaagccct 360 ggatcactcg ccagaacttc tcccggtgcc tggagctgca gtgtcagccc gactcctcaa 420 ccctgggcgg tggatcc 437 <210> 108 <211> 436 <212> DNA <213> Homo sapiens <400> 108 ggatccggag gtacccagga ctgctccttc caacacagcc ccatctcctc cgacttcgct 60 gtcaaaatcc gtgagctgtc tgactacctg cttcaagatt acccagtcac cgtggcctcc 120 aacctgcagg acgaggagct ctgcgggggc ctctggcggc tggtcctggc acagcgctgg 180 atggagcggc tcaagactgt cgctgggtcc aagatgcaag gcttgctgga gcgcgtgaac 240 acggagatac actttgtcac caaatgtgcc tttcagcccc cccccagctg tcttcgcttc 300 gtccagacca acatctcccg cctcctgcag gagacctccg agcagctggt ggcgctgaag 360 ccctggatca ctcgccagaa cttctcccgg tgcctggagc tgcagtgtca gcccgactcc 420 tcaaccctgt aagctt 436 <210> 109 <211> 449 <212> DNA <213> Homo sapiens <400> 109 ccatggccac ccaggactgc tccttccaac acagccccat ctcctccgac ttcgctgtca 60 aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg gcctccaacc 120 tgcaggacga ggagctctgc gggggcctct ggcggctggt cctggcacag cgctggatgg 180 agcggctcaa gactgtcgct gggtccaaga tgcaaggctt gctggagcgc gtgaacacgg 240 agatacactt tgtcaccaaa tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc 300 agaccaacat ctcccgcctc ctgcaggaga cctccgagca gctggtggcg ctgaagccct 360 ggatcactcg ccagaacttc tcccggtgcc tggagctgca gtgtcagccc gactcctcaa 420 ccctgggcgg tgggtcagga ggtggatcc 449 <210> 110 <211> 439 <212> DNA <213> Homo sapiens <400> 110 ggatccggag gtggcaccca ggactgctcc ttccaacaca gccccatctc ctccgacttc 60 gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag attacccagt caccgtggcc 120 tccaacctgc aggacgagga gctctgcggg ggcctctggc ggctggtcct ggcacagcgc 180 tggatggagc ggctcaagac tgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 240 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 300 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 360 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 420 tcctcaaccc tgtaagctt 439 <210> 111 <211> 461 <212> DNA <213> Homo sapiens <400> 111 ccatggccac ccaggactgc tccttccaac acagccccat ctcctccgac ttcgctgtca 60 aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg gcctccaacc 120 tgcaggacga ggagctctgc gggggcctct ggcggctggt cctggcacag cgctggatgg 180 agcggctcaa gactgtcgct gggtccaaga tgcaaggctt gctggagcgc gtgaacacgg 240 agatacactt tgtcaccaaa tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc 300 agaccaacat ctcccgcctc ctgcaggaga cctccgagca gctggtggcg ctgaagccct 360 ggatcactcg ccagaacttc tcccggtgcc tggagctgca gtgtcagccc gactcctcaa 420 ccctgggcgg tgggtcagga ggtgggtcag gaggtggatc c 461 <210> 112 <211> 457 <212> DNA <213> Homo sapiens <400> 112 ggatccggag gtggctcagg gggaggtagt ggtacccagg actgctcctt ccaacacagc 60 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 120 tacccagtca ccgtggcctc caacctgcag gacgaggagc tctgcggggg cctctggcgg 180 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctgggtc caagatgcaa 240 ggcttgctgg agcgcgtgaa cacggagata cactttgtca ccaaatgtgc ctttcagccc 300 ccccccagct gtcttcgctt cgtccagacc aacatctccc gcctcctgca ggagacctcc 360 gagcagctgg tggcgctgaa gccctggatc actcgccaga acttctcccg gtgcctggag 420 ctgcagtgtc agcccgactc ctcaaccctg taagctt 457 <210> 113 <211> 438 <212> DNA <213> Homo sapiens <400> 113 gccgacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg gatccggagg tacccaggac tgctccttcc aacacagccc catctcctcc 360 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 420 gtggcctcca acctgcag 438 <210> 114 <211> 441 <212> DNA <213> Homo sapiens <400> 114 gccgacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg gatccggagg tggcacccag gactgctcct tccaacacag ccccatctcc 360 tccgacttcg ctgtcaaaat ccgtgagctg tctgactacc tgcttcaaga ttacccagtc 420 accgtggcct ccaacctgca g 441 <210> 115 <211> 450 <212> DNA <213> Homo sapiens <400> 115 gccgacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tggatccgga ggtacccagg actgctcctt ccaacacagc 360 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 420 tacccagtca ccgtggcctc caacctgcag 450 <210> 116 <211> 459 <212> DNA <213> Homo sapiens <400> 116 gccgacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg gatccggagg tggctcaggg ggaggtagtg gtacccagga ctgctccttc 360 caacacagcc ccatctcctc cgacttcgct gtcaaaatcc gtgagctgtc tgactacctg 420 cttcaagatt acccagtcac cgtggcctcc aacctgcag 459 <210> 117 <211> 465 <212> DNA <213> Homo sapiens <400> 117 gccgacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggcac ccaggactgc 360 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 420 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgcag 465 <210> 118 <211> 483 <212> DNA <213> Homo sapiens <400> 118 gccgacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgccttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cag 483 <210> 119 <211> 843 <212> DNA <213> Homo sapiens <400> 119 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cacccaggac tgctccttcc aacacagccc catctcctcc 480 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 540 gtggcctcca acctgcagga cgaggagctc tgcggggcgc tctggcggct ggtcctggca 600 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 660 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccccc ccccagctgt 720 cttcgcttcg tccagaccaa catctcccgc ctcctgcagg agacctccga gcagctggtg 780 gcgctgaagc cctggatcac tcgccagaac ttctcccggt gcctggagct gcagtgtcag 840 ccc 843 <210> 120 <211> 858 <212> DNA <213> Homo sapiens <400> 120 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cacccaggac tgctccttcc aacacagccc catctcctcc 480 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 540 gtggcctcca acctgcagga cgaggagctc tgcggggcgc tctggcggct ggtcctggca 600 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 660 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccccc ccccagctgt 720 cttcgcttcg tccagaccaa catctcccgc ctcctgcagg agacctccga gcagctggtg 780 gcgctgaagc cctggatcac tcgccagaac ttctcccggt gcctggagct gcagtgtcag 840 cccgactcct caaccctg 858 <210> 121 <211> 888 <212> DNA <213> Homo sapiens <400> 121 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gtcaggcggt aacggcagtg gaggtaatgg cacccaggac 780 tgctccttcc aacacagccc catctcctcc gacttcgctg tcaaaatccg tgagctgtct 840 gactacctgc ttcaagatta cccagtcacc gtggcctcca acctgcag 888 <210> 122 <211> 903 <212> DNA <213> Homo sapiens <400> 122 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gtctggaggt aacggatccg gtggcaatgg gagcggcgga 780 aatggaaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 840 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 900 cag 903 <210> 123 <211> 873 <212> DNA <213> Homo sapiens <400> 123 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ctccaagatg caaggcttgc tggagcgcgt gaacacggag 480 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 540 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 600 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 660 ctgtctggcg gcaacggcac gcaggactgc tccttccaac acagccccat ctcctccgac 720 ttcgctgtca aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg 780 gcctccaacc tgcaggacga ggagctctgc gggggcctct ggcggctggt cctggcacag 840 cgctggatgg agcggctcaa gactgtcgct ggg 873 <210> 124 <211> 888 <212> DNA <213> Homo sapiens <400> 124 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ctccaagatg caaggcttgc tggagcgcgt gaacacggag 480 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 540 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 600 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 660 ctgtctggag gtaacggatc cggaggtaat ggcacccagg actgctcctt ccaacacagc 720 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 780 tacccagtca ccgtggcctc caacctgcag gacgaggagc tctgcggggg cctctggcgg 840 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctggg 888 <210> 125 <211> 903 <212> DNA <213> Homo sapiens <400> 125 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ctccaagatg caaggcttgc tggagcgcgt gaacacggag 480 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 540 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 600 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 660 ctgtctggag gtaacggatc cggtggcaat gggagcggcg gaaatggaac ccaggactgc 720 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 780 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgcaggacga ggagctctgc 840 gggggcctct ggcggctggt cctggcacag cgctggatgg agcggctcaa gactgtcgct 900 ggg 903 <210> 126 <211> 873 <212> DNA <213> Homo sapiens <400> 126 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cccccccagc tgtcttcgct tcgtccagac caacatctcc 480 cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat cactcgccag 540 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct gtctggcggc 600 aacggcaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 660 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 720 caggacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 780 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 840 atacactttg tcaccaaatg tgcctttcag ccc 873 <210> 127 <211> 888 <212> DNA <213> Homo sapiens <400> 127 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cccccccagc tgtcttcgct tcgtccagac caacatctcc 480 cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat cactcgccag 540 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct gtcaggcggt 600 aacggcagtg gaggtaatgg cacccaggac tgctccttcc aacacagccc catctcctcc 660 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 720 gtggcctcca acctgcagga cgaggagctc tgcgggggcc tctggcggct ggtcctggca 780 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 840 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccc 888 <210> 128 <211> 903 <212> DNA <213> Homo sapiens <400> 128 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cccccccagc tgtcttcgct tcgtccagac caacatctcc 480 cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat cactcgccag 540 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct gtctggaggt 600 aacggcagtg gtggtaatgg gagcggcgga aatggaaccc aggactgctc cttccaacac 660 agccccatct cctccgactt cgctgtcaaa atccgtgagc tgtctgacta cctgcttcaa 720 gattacccag tcaccgtggc ctccaacctg caggacgagg agctctgcgg gggcctctgg 780 cggctggtcc tggcacagcg ctggatggag cggctcaaga ctgtcgctgg gtccaagatg 840 caaggcttgc tggagcgcgt gaacacggag atacactttg tcaccaaatg tgcctttcag 900 ccc 903 <210> 129 <211> 843 <212> DNA <213> Homo sapiens <400> 129 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc gactcaggac tgttctttcc aacacagccc catctcctcc 480 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 540 gtggcctcca acctgcagga cgaggagctc tgcgggggcc tctggcggct ggtcctggca 600 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 660 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccccc ccccagctgt 720 cttcgcttcg tccagaccaa catctcccgc ctcctgcagg agacctccga gcagctggtg 780 gcgctgaagc cctggatcac tcgccagaac ttctcccggt gcctggagct gcagtgtcag 840 ccc 843 <210> 130 <211> 858 <212> DNA <213> Homo sapiens <400> 130 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc aacccaggac tgctcttttc aacacagccc catctcctcc 480 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 540 gtggcctcca acctgcagga cgaggagctc tgcgggggcc tctggcggct ggtcctggca 600 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 660 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccccc ccccagctgt 720 cttcgcttcg tccagaccaa catctcccgc ctcctgcagg agacctccga gcagctggtg 780 gcgctgaagc cctggatcac tcgccagaac ttctcccggt gcctggagct gcagtgtcag 840 cccgactcct caaccctg 858 <210> 131 <211> 843 <212> DNA <213> Homo sapiens <400> 131 gccactcagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agccctacgt agagggcggt 420 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 480 aaagaatctc ataaatctcc aaacatggct aactgctcta taatgatcga tgaaattata 540 catcacttaa agagaccacc taaccctttg ctggacccga acaacctcaa ttctgaagac 600 atggatatcc tgatggaacg aaaccttcga actccaaacc tgctcgcatt cgtaagggct 660 gtcaagcact tagaaaatgc atcaggtatt gaggcaattc ttcgtaatct ccaaccatgt 720 ctgccctctg ccacggccgc accctctcga catccaatca tcatcaaggc aggtgactgg 780 caagaattcc gggaaaaact gacgttctat ctggttaccc ttgagcaagc gcaggaacaa 840 cag 843 <210> 132 <211> 888 <212> DNA <213> Homo sapiens <400> 132 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc ccaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gtcaggcggt aacggcagtg gaggtaatgg cacccaggac 780 tgctccttcc aacacagccc catctcctcc gacttcgctg tcaaaatccg tgagctgtct 840 gactacctgc ttcaagatta cccagtcacc gtggcctcca acctgcag 888 <210> 133 <211> 903 <212> DNA <213> Homo sapiens <400> 133 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gtctggaggt aacggatccg gtggcaatgg gagcggcgga 780 aatggaaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 840 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 900 cag 903 <210> 134 <211> 873 <212> DNA <213> Homo sapiens <400> 134 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ctccaagatg caaggcttgc tggagcgcgt gaacacggag 480 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 540 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 600 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 660 ctgtctggcg gcaacggcac gcaggactgc tccttccaac acagccccat ctcctccgac 720 ttcgctgtca aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg 780 gcctccaacc tgcaggacga ggagctctgc gggggcctct ggcggctggt cctggcacag 840 cgctggatgg agcggctcaa gactgtcgct ggg 873 <210> 135 <211> 888 <212> DNA <213> Homo sapiens <400> 135 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ctccaagatg caaggcttgc tggagcgcgt gaacacggag 480 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 540 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 600 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 660 ctgtctggag gtaacggatc cggaggtaat ggcacccagg actgctcctt ccaacacagc 720 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 780 tacccagtca ccgtggcctc caacctgcag gacgaggagc tctgcggggg cctctggcgg 840 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctggg 888 <210> 136 <211> 903 <212> DNA <213> Homo sapiens <400> 136 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ctccaagatg caaggcttgc tggagcgcgt gaacacggag 480 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 540 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 600 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 660 ctgtctggag gtaacggatc cggtggcaat gggagcggcg gaaatggaac ccaggactgc 720 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 780 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgcaggacga ggagctctgc 840 gggggcctct ggcggctggt cctggcacag cgctggatgg agcggctcaa gactgtcgct 900 ggg 903 <210> 137 <211> 873 <212> DNA <213> Homo sapiens <400> 137 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cccccccagc tgtcttcgct tcgtccagac caacatctcc 480 cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat cactcgccag 540 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct gtctggcggc 600 aacggcacgc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 660 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 720 caggacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 780 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 840 atacactttg tcaccaaatg tgcctttcag ccc 873 <210> 138 <211> 888 <212> DNA <213> Homo sapiens <400> 138 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cccccccagc tgtcttcgct tcgtccagac caacatctcc 480 cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat cactcgccag 540 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct gtcaggcggt 600 aacggcagtg gaggtaatgg cacccaggac tgctccttcc aacacagccc catctcctcc 660 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 720 gtggcctcca acctgcagga cgaggagctc tgcgggggcc tctggcggct ggtcctggca 780 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 840 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccc 888 <210> 139 <211> 903 <212> DNA <213> Homo sapiens <400> 139 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cccccccagc tgtcttcgct tcgtccagac caacatctcc 480 cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat cactcgccag 540 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct gtctggaggt 600 aacggcagtg gtggcaatgg gagcggcgga aatggaaccc aggactgctc cttccaacac 660 agccccatct cctccgactt cgctgtcaaa atccgtgagc tgtctgacta cctgcttcaa 720 gattacccag tcaccgtggc ctccaacctg caggacgagg agctctgcgg gggcctctgg 780 cggctggtcc tggcacagcg ctggatggag cggctcaaga ctgtcgctgg gtccaagatg 840 caaggcttgc tggagcgcgt gaacacggag atacactttg tcaccaaatg tgcctttcag 900 ccc 903 <210> 140 <211> 888 <212> DNA <213> Homo sapiens <400> 140 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc ccaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gtctggaggt agtggatccg gaggttctgg cacccaggac 780 tgctccttcc aacacagccc catctcctcc gacttcgctg tcaaaatccg tgagctgtct 840 gactacctgc ttcaagatta cccagtcacc gtggcctcca acctgcag 888 <210> 141 <211> 903 <212> DNA <213> Homo sapiens <400> 141 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gtctggaggt agtggatccg gtggcagtgg gagcggcgga 780 tctggaaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 840 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 900 cag 903 <210> 142 <211> 858 <212> DNA <213> Homo sapiens <400> 142 gccacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 420 tacgtagagg gcggtggagg ctccccgggt gaaccgtctg gtccaatctc tactatcaac 480 ccgtctcctc cgtctaaaga atctcataaa tctccaaaca tggctaactg ctctataatg 540 atcgatgaaa ttatacatca cttaaagaga ccacctaacc ctttgctgga cccgaacaac 600 ctcaattctg aagacatgga tatcctgatg gaacgaaacc ttcgaactcc aaacctgctc 660 gcattcgtaa gggctgtcaa gcacttagaa aatgcatcag gtattgaggc aattcttcgt 720 aatctccaac catgtctgcc ctctgccacg gccgcaccct ctcgacatcc aatcatcatc 780 aaggcaggtg actggcaaga attccgggaa aaactgacgt tctatctggt tacccttgag 840 caagcgcagg aacaacag 858 <210> 143 <211> 876 <212> DNA <213> Homo sapiens <400> 143 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gggcggtgga tccggaggta cccaggactg ctccttccaa 780 cacagcccca tctcctccga cttcgctgtc aaaatccgtg agctgtctga ctacctgctt 840 caagattacc cagtcaccgt ggcctccaac ctgcag 876 <210> 144 <211> 879 <212> DNA <213> Homo sapiens <400> 144 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gggcggtgga tccggaggtg gcacccagga ctgctccttc 780 caacacagcc ccatctcctc cgacttcgct gtcaaaatcc gtgagctgtc tgactacctg 840 cttcaagatt acccagtcac cgtggcctcc aacctgcag 879 <210> 145 <211> 888 <212> DNA <213> Homo sapiens <400> 145 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gggcggtggg tcaggaggtg gatccggagg tacccaggac 780 tgctccttcc aacacagccc catctcctcc gacttcgctg tcaaaatccg tgagctgtct 840 gactacctgc ttcaagatta cccagtcacc gtggcctcca acctgcag 888 <210> 146 <211> 897 <212> DNA <213> Homo sapiens <400> 146 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gggcggtgga tccggaggtg gctcaggggg aggtagtggt 780 acccaggact gctccttcca acacagcccc atctcctccg acttcgctgt caaaatccgt 840 gagctgtctg actacctgct tcaagattac ccagtcaccg tggcctccaa cctgcag 897 <210> 147 <211> 903 <212> DNA <213> Homo sapiens <400> 147 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gggcggtggg tcaggaggtg ggtcaggagg tggatccgga 780 ggtggcaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 840 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 900 cag 903 <210> 148 <211> 921 <212> DNA <213> Homo sapiens <400> 148 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gggcggtggg tcaggaggtg ggtcaggagg tggatccgga 780 ggtggctcag ggggaggtag tggtacccag gactgctcct tccaacacag ccccatctcc 840 tccgacttcg ctgtcaaaat ccgtgagctg tctgactacc tgcttcaaga ttacccagtc 900 accgtggcct ccaacctgca g 921 <210> 149 <211> 876 <212> DNA <213> Homo sapiens <400> 149 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ctccaagatg caaggcttgc tggagcgcgt gaacacggag 480 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 540 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 600 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 660 ctgggcggtg gatccggagg tacccaggac tgctccttcc aacacagccc catctcctcc 720 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 780 gtggcctcca acctgcagga cgaggagctc tgcgggggcc tctggcggct ggtcctggca 840 cagcgctgga tggagcggct caagactgtc gctggg 876 <210> 150 <211> 879 <212> DNA <213> Homo sapiens <400> 150 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ctccaagatg caaggcttgc tggagcgcgt gaacacggag 480 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 540 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 600 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 660 ctgggcggtg gatccggagg tggcacccag gactgctcct tccaacacag ccccatctcc 720 tccgacttcg ctgtcaaaat ccgtgagctg tctgactacc tgcttcaaga ttacccagtc 780 accgtggcct ccaacctgca ggacgaggag ctctgcgggg gcctctggcg gctggtcctg 840 gcacagcgct ggatggagcg gctcaagact gtcgctggg 879 <210> 151 <211> 888 <212> DNA <213> Homo sapiens <400> 151 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ctccaagatg caaggcttgc tggagcgcgt gaacacggag 480 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 540 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 600 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 660 ctgggcggtg ggtcaggagg tggatccgga ggtacccagg actgctcctt ccaacacagc 720 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 780 tacccagtca ccgtggcctc caacctgcag gacgaggagc tctgcggggg cctctggcgg 840 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctggg 888 <210> 152 <211> 897 <212> DNA <213> Homo sapiens <400> 152 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ctccaagatg caaggcttgc tggagcgcgt gaacacggag 480 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 540 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 600 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 660 ctgggcggtg gatccggagg tggctcaggg ggaggtagtg gtacccagga ctgctccttc 720 caacacagcc ccatctcctc cgacttcgct gtcaaaatcc gtgagctgtc tgactacctg 780 cttcaagatt acccagtcac cgtggcctcc aacctgcagg acgaggagct ctgcgggggc 840 ctctggcggc tggtcctggc acagcgctgg atggagcggc tcaagactgt cgctggg 897 <210> 153 <211> 903 <212> DNA <213> Homo sapiens <400> 153 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ctccaagatg caaggcttgc tggagcgcgt gaacacggag 480 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 540 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 600 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 660 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggcac ccaggactgc 720 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 780 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgcaggacga ggagctctgc 840 gggggcctct ggcggctggt cctggcacag cgctggatgg agcggctcaa gactgtcgct 900 ggg 903 <210> 154 <211> 921 <212> DNA <213> Homo sapiens <400> 154 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ctccaagatg caaggcttgc tggagcgcgt gaacacggag 480 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 540 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 600 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 660 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 720 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 780 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 840 caggacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 900 cggctcaaga ctgtcgctgg g 921 <210> 155 <211> 876 <212> DNA <213> Homo sapiens <400> 155 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cccccccagc tgtcttcgct tcgtccagac caacatctcc 480 cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat cactcgccag 540 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct gggcggtgga 600 tccggaggta cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc 660 aaaatccgtg agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac 720 ctgcaggacg aggagctctg cgggggcctc tggcggctgg tcctggcaca gcgctggatg 780 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 840 gagatacact ttgtcaccaa atgtgccttt cagccc 876 <210> 156 <211> 879 <212> DNA <213> Homo sapiens <400> 156 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cccccccagc tgtcttcgct tcgtccagac caacatctcc 480 cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat cactcgccag 540 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct gggcggtgga 600 tccggaggtg gcacccagga ctgctccttc caacacagcc ccatctcctc cgacttcgct 660 gtcaaaatcc gtgagctgtc tgactacctg cttcaagatt acccagtcac cgtggcctcc 720 aacctgcagg atgaggagct ctgcgggggc ctctggcggc tggtcctggc acagcgctgg 780 atggagcggc tcaagactgt cgctgggtcc aagatgcaag gcttgctgga gcgcgtgaac 840 acggagatac actttgtcac caaatgtgcc tttcagccc 879 <210> 157 <211> 888 <212> DNA <213> Homo sapiens <400> 157 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cccccccagc tgtcttcgct tcgtccagac caacatctcc 480 cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat cactcgccag 540 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct gggcggtggg 600 tcaggaggtg gatccggagg tacccaggac tgctccttcc aacacagccc catctcctcc 660 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 720 gtggcctcca acctgcagga cgaggagctc tgcgggggcc tctggcggct ggtcctggca 780 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 840 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccc 888 <210> 158 <211> 897 <212> DNA <213> Homo sapiens <400> 158 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cccccccagc tgtcttcgct tcgtccagac caacatctcc 480 cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat cactcgccag 540 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct gggcggtgga 600 tccggaggtg gctcaggggg aggtagtggt acccaggact gctccttcca acacagcccc 660 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 720 ccagtcaccg tggcctccaa cctgcaggac gaggagctct gcgggggcct ctggcggctg 780 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctgggtccaa gatgcaaggc 840 ttgctggagc gcgtgaacac ggagatacac tttgtcacca aatgtgcctt tcagccc 897 <210> 159 <211> 903 <212> DNA <213> Homo sapiens <400> 159 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cccccccagc tgtcttcgct tcgtccagac caacatctcc 480 cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat cactcgccag 540 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct gggcggtggg 600 tcaggaggtg ggtcaggagg tggatccgga ggtggcaccc aggactgctc cttccaacac 660 agccccatct cctccgactt cgctgtcaaa atccgtgagc tgtctgacta cctgcttcaa 720 gattacccag tcaccgtggc ctccaacctg caggacgagg agctctgcgg gggcctctgg 780 cggctggtcc tggcacagcg ctggatggag cggctcaaga ctgtcgctgg gtccaagatg 840 caaggcttgc tggagcgcgt gaacacggag atacactttg tcaccaaatg tgcctttcag 900 ccc 903 <210> 160 <211> 921 <212> DNA <213> Homo sapiens <400> 160 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cccccccagc tgtcttcgct tcgtccagac caacatctcc 480 cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat cactcgccag 540 aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct gggcggtggg 600 tcaggaggtg ggtcaggagg tggatccgga ggtggctcag ggggaggtag tggtacccag 660 gactgctcct tccaacacag ccccatctcc tccgacttcg ctgtcaaaat ccgtgagctg 720 tctgactacc tgcttcaaga ttacccagtc accgtggcct ccaacctgca ggacgaggag 780 ctctgcgggg gcctctggcg gctggtcctg gcacagcgct ggatggagcg gctcaagact 840 gtcgctgggt ccaagatgca aggcttgctg gagcgcgtga acacggagat acactttgtc 900 accaaatgtg cctttcagcc c 921 <210> 161 <211> 888 <212> DNA <213> Homo sapiens <400> 161 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagctctgcg ggggcctctg gcggctggtc ctggcacagc gctggatgga gcggctcaag 540 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 600 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 660 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 720 cagaacttct cccggtgcct ggagctgcag tgtcagcccg actcctcaac cctgggcggt 780 gggtcaggag gtggatccgg aggtacccag gactgctcct tccaacacag ccccatctcc 840 tccgacttcg ctgtcaaaat ccgtgagctg tctgactacc tgcttcaa 888 <210> 162 <211> 903 <212> DNA <213> Homo sapiens <400> 162 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagctctgcg ggggcctctg gcggctggtc ctggcacagc gctggatgga gcggctcaag 540 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 600 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 660 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 720 cagaacttct cccggtgcct ggagctgcag tgtcagcccg actcctcaac cctgggcggt 780 gggtcaggag gtgggtcagg aggtggatcc ggaggtggca cccaggactg ctccttccaa 840 cacagcccca tctcctccga cttcgctgtc aaaatccgtg agctgtctga ctacctgctt 900 caa 903 <210> 163 <211> 888 <212> DNA <213> Homo sapiens <400> 163 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgcctccaac ctgcaggacg aggagctctg cgggggcctc 480 tggcggctgg tcctggcaca gcgctggatg gagcggctca agactgtcgc tgggtccaag 540 atgcaaggct tgctggagcg cgtgaacacg gagatacact ttgtcaccaa atgtgccttt 600 cagccccccc ccagctgtct tcgcttcgtc cagaccaaca tctcccgcct cctgcaggag 660 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 720 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtgggtcagg aggtggatcc 780 ggaggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 840 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtg 888 <210> 164 <211> 903 <212> DNA <213> Homo sapiens <400> 164 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagaaggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgcctccaac ctgcaggacg aggagctctg cgggggcctc 480 tggcggctgg tcctggcaca gcgctggatg gagcggctca agactgtcgc tgggtccaag 540 atgcaaggct tgctggagcg cgtgaacacg gagatacact ttgtcaccaa atgtgccttt 600 cagccccccc ccagctgtct tcgcttcgtc cagaccaaca tctcccgcct cctgcaggag 660 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 720 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtgggtcagg aggtgggtca 780 ggaggtggat ccggaggtgg cacccaggac tgctccttcc aacacagccc catctcctcc 840 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 900 gtg 903 <210> 165 <211> 888 <212> DNA <213> Homo sapiens <400> 165 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 480 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 540 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 600 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 660 tcctcaaccc tgggcggtgg gtcaggaggt ggatccggag gtacccagga ctgctccttc 720 caacacagcc ccatctcctc cgacttcgct gtcaaaatcc gtgagctgtc tgactacctg 780 cttcaagatt acccagtcac cgtggcctcc aacctgcagg acgaggagct ctgcgggggc 840 ctctggcggc tggtcctggc acagcgctgg atggagcggc tcaagact 888 <210> 166 <211> 903 <212> DNA <213> Homo sapiens <400> 166 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 480 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 540 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 600 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 660 tcctcaaccc tgggcggtgg gtcaggaggt gggtcaggag gtggatccgg aggtggcacc 720 caggactgct ccttccaaca cagccccatc tcctccgact tcgctgtcaa aatccgtgag 780 ctgtctgact acctgcttca agattaccca gtcaccgtgg cctccaacct gcaggacgag 840 gagctctgcg ggggcctctg gcggctggtc ctggcacagc gctggatgga gcggctcaag 900 act 903 <210> 167 <211> 888 <212> DNA <213> Homo sapiens <400> 167 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ccgcttcgtc cagaccaaca tctcccgcct cctgcaggag 480 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 540 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtgggtcagg aggtggatcc 600 ggaggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 660 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 720 caggacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 780 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 840 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtctt 888 <210> 168 <211> 903 <212> DNA <213> Homo sapiens <400> 168 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ccgcttcgtc cagaccaaca tctcccgcct cctgcaggag 480 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 540 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtgggtcagg aggtgggtca 600 ggaggtggat ccggaggtgg cacccaggac tgctccttcc aacacagccc catctcctcc 660 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 720 gtggcctcca acctgcagga cgaggagctc tgcgggggcc tctggcggct ggtcctggca 780 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 840 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccccc ccccagctgt 900 ctt 903 <210> 169 <211> 888 <212> DNA <213> Homo sapiens <400> 169 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaagctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc caccaacatc tcccgcctcc tgcaggagac ctccgagcag 480 ctggtggcgc tgaagccctg gatcactcgc cagaacttct cccggtgcct ggagctgcag 540 tgtcagcccg actcctcaac cctgggcggt gggtcaggag gtggatccgg aggtacccag 600 gactgctcct tccaacacag ccccatctcc tccgacttcg ctgtcaaaat ccgtgagctg 660 tctgactacc tgcttcaaga ttacccagtc accgtggcct ccaacctgca ggacgaggag 720 ctctgcgggg gcctctggcg gctggtcctg gcacagcgct ggatggagcg gctcaagact 780 gtcgctgggt ccaagatgca aggcttgctg gagcgcgtga acacggagat acactttgtc 840 accaaatgtg cctttcagcc cccccccagc tgtcttcgct tcgtccag 888 <210> 170 <211> 903 <212> DNA <213> Homo sapiens <400> 170 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc caccaacatc tcccgcctcc tgcaggagac ctccgagcag 480 ctggtggcgc tgaagccctg gatcactcgc cagaacttct cccggtgcct ggagctgcag 540 tgtcagcccg actcctcaac cctgggcggt gggtcaggag gtgggtcagg aggtggatcc 600 ggaggtggca cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc 660 aaaatccgtg agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac 720 ctgcaggacg aggagctctg cgggggcctc tggcggctgg tcctggcaca gcgctggatg 780 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 840 gagatacact ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc 900 cag 903 <210> 171 <211> 876 <212> DNA <213> Homo sapiens <400> 171 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagctctgcg ggggcctctg gcggctggtc ctggcacagc gctggatgga gcggctcaag 540 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 600 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 660 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 720 cagaacttct cccggtgcct ggagctgcag tgtcagcccg actcctcaac cctgggcggt 780 ggatccggag gtacccagga ctgctccttc caacacagcc ccatctcctc cgacttcgct 840 gtcaaaatcc gtgagctgtc tgactacctg cttcaa 876 <210> 172 <211> 879 <212> DNA <213> Homo sapiens <400> 172 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagctctgcg ggggcctctg gcggctggtc ctggcacagc gctggatgga gcggctcaag 540 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 600 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 660 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 720 cagaacttct cccggtgcct ggagctgcag tgtcagcccg actcctcaac cctgggcggt 780 ggatccggag gtggcaccca ggactgctcc ttccaacaca gccccatctc ctccgacttc 840 gctgtcaaaa tccgtgagct gtctgactac ctgcttcaa 879 <210> 173 <211> 897 <212> DNA <213> Homo sapiens <400> 173 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagctctgcg ggggcctctg gcggctggtc ctggcacagc gctggatgga gcggctcaag 540 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 600 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 660 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 720 cagaacttct cccggtgcct ggagctgcag tgtcagcccg actcctcaac cctgggcggt 780 ggatccggag gtggctcagg gggaggtagt ggtacccagg actgctcctt ccaacacagc 840 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaa 897 <210> 174 <211> 921 <212> DNA <213> Homo sapiens <400> 174 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagctctgcg ggggcctctg gcggctggtc ctggcacagc gctggatgga gcggctcaag 540 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 600 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 660 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 720 cagaacttct cccggtgcct ggagctgcag tgtcagcccg actcctcaac cctgggcggt 780 gggtcaggag gtgggtcagg aggtggatcc ggaggtggct cagggggagg tagtggtacc 840 caggactgct ccttccaaca cagccccatc tcctccgact tcgctgtcaa aatccgtgag 900 ctgtctgact acctgcttca a 921 <210> 175 <211> 869 <212> DNA <213> Homo sapiens <400> 175 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgcctccaac ctgcaggacg aggagctctg cgggggcctc 480 tggcggctgg tcctggcaca gcgctggatg gagcggctca agactgtcgc tgggtccaag 540 atgcaaggct tgctggagcg cgtgaacacg gagatacact ttgtcaccaa atgtgccttt 600 cagccccccc ccagctgtct tcgcttcgtc cagaccaaca tctcccgcct cctgcaggag 660 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 720 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtggatccgg aggtactgct 780 ccttccaaca cagccccatc tcctccgact tcgctgtcaa aatccgtgag ctgtctgact 840 acctgcttca agattaccca gtcaccgtg 869 <210> 176 <211> 872 <212> DNA <213> Homo sapiens <400> 176 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgcctccaac ctgcaggacg aggagctctg cgggggcctc 480 tggcggctgg tcctggcaca gcgctggatg gagcggctca agactgtcgc tgggtccaag 540 atgcaaggct tgctggagcg cgtgaacacg gagatacact ttgtcaccaa atgtgccttt 600 cagccccccc ccagctgtct tcgcttcgtc cagaccaaca tctcccgcct cctgcaggag 660 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 720 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtggatccgg aggtggcact 780 gctccttcca acacagcccc atctcctccg acttcgctgt caaaatccgt gagctgtctg 840 actacctgct tcaagattac ccagtcaccg tg 872 <210> 177 <211> 890 <212> DNA <213> Homo sapiens <400> 177 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgcctccaac ctgcaggacg aggagctctg cgggggcctc 480 tggcggctgg tcctggcaca gcgctggatg gagcggctca agactgtcgc tgggtccaag 540 atgcaaggct tgctggagcg cgtgaacacg gagatacact ttgtcaccaa atgtgccttt 600 cagccccccc ccagctgtct tcgcttcgtc cagaccaaca tctcccgcct cctgcaggag 660 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 720 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtggatccgg aggtggctca 780 gggggaggta gtggtactgc tccttccaac acagccccat ctcctccgac ttcgctgtca 840 aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg 890 <210> 178 <211> 917 <212> DNA <213> Homo sapiens <400> 178 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgcctccaac ctgcaggacg aggagctctg cgggggcctc 480 tggcggctgg tcctggcaca gcgctggatg gagcggctca agactgtcgc tgggtccaag 540 atgcaaggct tgctggagcg cgtgaacacg gagatacact ttgtcaccaa atgtgccttt 600 cagccccccc ccagctgtct tcgcttcgtc cagaccaaca tctcccgcct cctgcaggag 660 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 720 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtgggtcagg aggtgggtca 780 ggaggtggat ccggaggtgg ctcaggggga ggtagtggta ggactgctcc ttccaacaca 840 gccccatctc ctccgacttc gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag 900 attacccagt caccgtg 917 <210> 179 <211> 876 <212> DNA <213> Homo sapiens <400> 179 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 480 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 540 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 600 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 660 tcctcaaccc tgggcggtgg atccggaggt acccaggact gctccttcca acacagcccc 720 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 780 ccagtcaccg tggcctccaa cctgcaggac gaggagctct gcgggggcct ctggcggctg 840 gtcctggcac agcgctggat ggagcggctc aagact 876 <210> 180 <211> 879 <212> DNA <213> Homo sapiens <400> 180 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 480 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 540 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 600 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 660 tcctcaaccc tgggcggtgg atccggaggt ggcacccagg actgctcctt ccaacacagc 720 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 780 tacccagtca ccgtggcctc caacctgcag gacgaggagc tctgcggggg cctctggcgg 840 ctggtcctgg cacagcgctg gatggagcgg ctcaagact 879 <210> 181 <211> 897 <212> DNA <213> Homo sapiens <400> 181 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 480 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 540 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 600 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 660 tcctcaaccc tgggcggtgg atccggaggt ggctcagggg gaggtagtgg tacccaggac 720 tgctccttcc aacacagccc catctcctcc gacttcgctg tcaaaatccg tgagctgtct 780 gactacctgc ttcaagatta cccagtcacc gtggcctcca acctgcagga cgaggagctc 840 tgcgggggcc tctggcggct ggtcctggca cagcgctgga tggagcggct caagact 897 <210> 182 <211> 921 <212> DNA <213> Homo sapiens <400> 182 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 480 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 540 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 600 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 660 tcctcaaccc tgggcggtgg gtcaggaggt gggtcaggag gtggatccgg aggtggctca 720 gggggaggta gtggtaccca ggactgctcc ttccaacaca gccccatctc ctccgacttc 780 gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag attacccagt caccgtggcc 840 tccaacctgc aggacgagga gctctgcggg ggcctctggc ggctggtcct ggcacagcgc 900 tggatggagc ggctcaagac t 921 <210> 183 <211> 876 <212> DNA <213> Homo sapiens <400> 183 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ccgcttcgtc cagaccaaca tctcccgcct cctgcaggag 480 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 540 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtggatccgg aggtacccag 600 gactgctcct tccaacacag ccccatctcc tccgacttcg ctgtcaaaat ccgtgagctg 660 tctgactacc tgcttcaaga ttacccagtc accgtggcct ccaacctgca ggacgaggag 720 ctctgcgggg gcctctggcg gctggtcctg gcacagcgct ggatggagcg gctcaagact 780 gtcgctgggt ccaagatgca aggcttgctg gagcgcgtga acacggagat acactttgtc 840 accaaatgtg cctttcagcc cccccccagc tgtctt 876 <210> 184 <211> 879 <212> DNA <213> Homo sapiens <400> 184 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ccgcttcgtc cagaccaaca tctcccgcct cctgcaggag 480 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 540 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtggatccgg aggtggcacc 600 caggactgct ccttccaaca cagccccatc tcctccgact tcgctgtcaa aatccgtgag 660 ctgtctgact acctgcttca agattaccca gtcaccgtgg cctccaacct gcaggacgag 720 gagctctgcg ggggcctctg gcggctggtc ctggcacagc gctggatgga gcggctcaag 780 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 840 gtcaccaaat gtgcctttca gccccccccc agctgtctt 879 <210> 185 <211> 897 <212> DNA <213> Homo sapiens <400> 185 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ccgcttcgtc cagaccaaca tctcccgcct cctgcaggag 480 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 540 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtggatccgg aggtggctca 600 gggggaggta gtggtaccca ggactgctcc ttccaacaca gccccatctc ctccgacttc 660 gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag attacccagt caccgtggcc 720 tccaacctgc aggacgagga gctctgcggg ggcctctggc ggctggtcct ggcacagcgc 780 tggatggagc ggctcaagac tgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 840 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtctt 897 <210> 186 <211> 921 <212> DNA <213> Homo sapiens <400> 186 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ccgcttcgtc cagaccaaca tctcccgcct cctgcaggag 480 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 540 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtgggtcagg aggtgggtca 600 ggaggtggat ccggaggtgg ctcaggggga ggtagtggta cccaggactg ctccttccaa 660 cacagcccca tctcctccga cttcgctgtc aaaatccgtg agctgtctga ctacctgctt 720 caagattacc cagtcaccgt ggcctccaac ctgcaggacg aggagctctg cgggggcctc 780 tggcggctgg tcctggcaca gcgctggatg gagcggctca agactgtcgc tgggtccaag 840 atgcaaggct tgctggagcg cgtgaacacg gagatacact ttgtcaccaa atgtgccttt 900 cagccccccc ccagctgtct t 921 <210> 187 <211> 876 <212> DNA <213> Homo sapiens <400> 187 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaagctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc caccaacatc tcccgcctcc tgcaggagac ctccgagcag 480 ctggtggcgc tgaagccctg gatcactcgc cagaacttct cccggtgcct ggagctgcag 540 tgtcagcccg actcctcaac cctgggcggt ggatccggag gtacccagga ctgctccttc 600 caacacagcc ccatctcctc cgacttcgct gtcaaaatcc gtgagctgtc tgactacctg 660 cttcaagatt acccagtcac cgtggcctcc aacctgcagg acgaggagct ctgcgggggc 720 ctctggcggc tggtcctggc acagcgctgg atggagcggc tcaagactgt cgctgggtcc 780 aagatgcaag gcttgctgga gcgcgtgaac acggagatac actttgtcac caaatgtgcc 840 tttcagcccc cccccagctg tcttcgcttc gtccag 876 <210> 188 <211> 879 <212> DNA <213> Homo sapiens <400> 188 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaagctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc caccaacatc tcccgcctcc tgcaggagac ctccgagcag 480 ctggtggcgc tgaagccctg gatcactcgc cagaacttct cccggtgcct ggagctgcag 540 tgtcagcccg actcctcaac cctgggcggt ggatccggag gtggcaccca ggactgctcc 600 ttccaacaca gccccatctc ctccgacttc gctgtcaaaa tccgtgagct gtctgactac 660 ctgcttcaag attacccagt caccgtggcc tccaacctgc aggacgagga gctctgcggg 720 ggcctctggc ggctggtcct ggcacagcgc tggatggagc ggctcaagac tgtcgctggg 780 tccaagatgc aaggcttgct ggagcgcgtg aacacggaga tacactttgt caccaaatgt 840 gcctttcagc ccccccccag ctgtcttcgc ttcgtccag 879 <210> 189 <211> 897 <212> DNA <213> Homo sapiens <400> 189 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaagctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc caccaacatc tcccgcctcc tgcaggagac ctccgagcag 480 ctggtggcgc tgaagccctg gatcactcgc cagaacttct cccggtgcct ggagctgcag 540 tgtcagcccg actcctcaac cctgggcggt ggatccggag gtggctcagg gggaggtagt 600 ggtacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 660 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 720 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 780 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 840 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccag 897 <210> 190 <211> 921 <212> DNA <213> Homo sapiens <400> 190 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc caccaacatc tcccgcctcc tgcaggagac ctccgagcag 480 ctggtggcgc tgaagccctg gatcactcgc cagaacttct cccggtgcct ggagctgcag 540 tgtcagcccg actcctcaac cctgggcggt gggtcaggag gtgggtcagg aggtggatcc 600 ggaggtggct cagggggagg tagtggtacc caggactgct ccttccaaca cagccccatc 660 tcctccgact tcgctgtcaa aatccgtgag ctgtctgact acctgcttca agattaccca 720 gtcaccgtgg cctccaacct gcaggacgag gagctctgcg ggggcctctg gcggctggtc 780 ctggcacagc gctggatgga gcggctcaag actgtcgctg ggtccaagat gcaaggcttg 840 ctggagcgcg tgaacacgga gatacacttt gtcaccaaat gtgcctttca gccccccccc 900 agctgtcttc gcttcgtcca g 921 <210> 191 <211> 2247 <212> DNA <213> Homo sapiens <400> 191 ggatccacca tgagccgcct gcccgtcctg ctcctgctcc aactcctggt ccgccccgcc 60 atgtctacaa atcaagatct gcctgtgatc aagtgtgttt taatcaatca taagaacaat 120 gattcatcag tggggaagtc atcatcatat cccatggtat cagaatcccc ggaagacctc 180 gggtgtgcgt tgagacccca gagctcaggg acagtgtacg aagctgccgc tgtggaagtg 240 gatgtatctg cttccatcac actgcaagtg ctggtcgatg ccccagggaa catttcctgt 300 ctctgggtct ttaagcacag ctccctgaat tgccagccac attttgattt acaaaacaga 360 ggagttgttt ccatggtcat tttgaaaatg acagaaaccc aagctggaga atacctactt 420 tttattcaga gtgaagctac caattacaca atattgttta cagtgagtat aagaaatacc 480 ctgctttaca cattaagaag accttacttt agaaaaatgg aaaaccagga cgccctggtc 540 tgcatatctg agagcgttcc agagccgatc gtggaatggg tgctttgcga ttcacagggg 600 gaaagctgta aagaagaaag tccagctgtt gttaaaaagg aggaaaaagt gcttcatgaa 660 ttatttggga tggacataag gtgctgtgcc agaaatgaac tgggcaggga atgcaccagg 720 ctgttcacaa tagatctaaa tcaaactcct cagaccacat tgccacaatt atttcttaaa 780 gtaggggaac ccttatggat aaggtgcaaa gctgttcatg tgaaccatgg attcgggctc 840 acctgggaat tagaaaacaa agcactcgag gagggcaact actttgagat gagtacctat 900 tcaacaaaca gaactatgat acggattctg tttgcttttg tatcatcagt ggcaagaaac 960 gacaccggat actacacttg ttcctcttca aagcatccca gtcaatcagc tttggttacc 1020 atcgtagaaa agggatttat aaatgctacc aattcaagtg aagattatga aattgaccaa 1080 tatgaagagt tttgtttttc tgtcaggttt aaagcctacc cacaaatcag atgtacgtgg 1140 accttctctc gaaaatcatt tccttgtgag caaaagggtc ttgataacgg atacagcata 1200 tccaagtttt gcaatcataa gcaccagcca ggagaatata tattccatgc agaaaatgat 1260 gatgcccaat ttaccaaaat gttcacgctg aatataagaa ggaaacctca agtgctcgca 1320 gaagcatcgg caagtcaggc gtcctgtttc tcggatggat acccattacc atcttggacc 1380 tggaagaagt gttcagacaa gtctcccaac tgcacagaag agatcacaga aggagtctgg 1440 aatagaaagg ctaacagaaa agtgtttgga cagtgggtgt cgagcagtac tctaaacatg 1500 agtgaagcca taaaagggtt cctggtcaag tgctgtgcat acaattccct tggcacatct 1560 tgtgagacga tccttttaaa ctctccaggc cccttccctt tcatccaaga caacgaattc 1620 atcatcctgg gcctgttcgg cctcctgctg ttgctcacct gcctctgtgg aactgcctgg 1680 ctctgttgca gccccaacag gaagaatccc ctctggccaa gtgtcccaga cccagctcac 1740 agcagcctgg gctcctgggt gcccacaatc atggaggagg atgccttcca gctgcccggc 1800 cttggcacgc cacccatcac caagctcaca gtgctggagg aggatgaaaa gaagccggtg 1860 ccctgggagt cccataacag ctcagagacc tgtggcctcc ccactctggt ccagacctat 1920 gtgctccagg gggacccaag agcagtttcc acccagcccc aatcccagtc tggcaccagc 1980 gatcaggtcc tttatgggca gctgctgggc agccccacaa gcccagggcc agggcactat 2040 ctccgctgtg actccactca gcccctcttg gcgggcctca cccccagccc caagtcctat 2100 gagaacctct ggttccaggc cagccccttg gggaccctgg taaccccagc cccaagccag 2160 gaggacgact gtgtctttgg gccactgctc aacttccccc tcctgcaggg gatccgggtc 2220 catgggatgg aggcgctggg gagcttc 2247 <210> 192 <211> 1047 <212> DNA <213> Homo sapiens <400> 192 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggcc acccaggact gctccttcca acacagcccc 660 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 720 ccagtcaccg tggcctccaa cctgcaggac gaggagctct gcgggggcct ctggcggctg 780 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctgggtccaa gatgcaaggc 840 ttgctggagc gcgtgaacac ggagatacac tttgtcacca aatgtgcctt tcagcccccc 900 cccagctgtc ttcgcttcgt ccagaccaac atctcccgcc tcctgcagga gacctccgag 960 cagctggtgg cgctgaagcc ctggatcact cgccagaact tctcccggtg cctggagctg 1020 cagtgtcagc ccgactcctc aaccctg 1047 <210> 193 <211> 942 <212> DNA <213> Homo sapiens <400> 193 gccactcagg actgctcttt tcaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 420 tacgtagagg gcggtggagg ctccccgggt gaaccgtctg gtccaatctc tactatcaac 480 ccgtctcctc cgtctaaaga atctcataaa tctccaaaca tggctaccca ggactgctcc 540 ttccaacaca gccccatctc ctccgacttc gctgtcaaaa tccgtgagct gtctgactac 600 ctgcttcaag attacccagt caccgtggcc tccaacctgc aggacgagga gctctgcggg 660 ggcctctggc ggctggtcct ggcacagcgc tggatggagc ggctcaagac tgtcgctggg 720 tccaagatgc aaggcttgct ggagcgcgtg aacacggaga tacactttgt caccaaatgt 780 gcctttcagc ccccccccag ctgtcttcgc ttcgtccaga ccaacatctc ccgcctcctg 840 caggagacct ccgagcagct ggtggcgctg aagccctgga tcactcgcca gaacttctcc 900 cggtgcctgg agctgcagtg tcagcccgac tcctcaaccc tg 942 <210> 194 <211> 1047 <212> DNA <213> Homo sapiens <400> 194 gccacccagg actgctcctt tcaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccatggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 420 tacgtagagg gcggtggagg ctccccgggt gaaccgtctg gtccaatctc tactatcaac 480 ccgtctcctc cgtctaaaga atctcataaa tctccaaaca tggctacacc attaggccct 540 gccagctccc tgccccagag cttcctgctc aagtgcttag agcaagtgag gaagatccag 600 ggcgatggcg cagcgctcca ggagaagctg tgtgccacct acaagctgtg ccaccccgag 660 gagctggtgc tgctcggaca ctctctgggc atcccctggg ctcccctgag ctcctgcccc 720 agccaggccc tgcagctggc aggctgcttg agccaactcc atagcggcct tttcctctac 780 caggggctcc tgcaggccct ggaagggata tcccccgagt tgggtcccac cttggacaca 840 ctgcagctgg acgtcgccga ctttgccacc accatctggc agcagatgga agaactggga 900 atggcccctg ccctgcagcc cacccagggt gccatgccgg ccttcgcctc tgctttccag 960 cgccgggcag gaggggtcct ggttgctagc catctgcaga gcttcctgga ggtgtcgtac 1020 cgcgttttac gccaccttgc gcagccc 1047 <210> 195 <211> 1569 <212> DNA <213> Homo sapiens <400> 195 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggcc actcaggact gctcttttca acacagcccc 660 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 720 ccagtcaccg tggcctccaa cctgcaggac gaggagctct gcgggggcct ctggcggctg 780 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctgggtccaa gatgcaaggc 840 ttgctggagc gcgtgaacac ggagatacac tttgtcacca aatgtgcctt tcagcccccc 900 cccagctgtc ttcgcttcgt ccagaccaac atctcccgcc tcctgcagga gacctccgag 960 cagctggtgg cgctgaagcc ctggatcact cgccagaact tctcccggtg cctggagctg 1020 cagtgtcagc ccgactcctc aaccctgtac gtagagggcg gtggaggctc cccgggtgaa 1080 ccgtctggtc caatctctac tatcaacccg tctcctccgt ctaaagaatc tcataaatct 1140 ccaaacatgg ctacccagga ctgctccttc caacacagcc ccatctcctc cgacttcgct 1200 gtcaaaatcc gtgagctgtc tgactacctg cttcaagatt acccagtcac cgtggcctcc 1260 aacctgcagg acgaggagct ctgcgggggc ctctggcggc tggtcctggc acagcgctgg 1320 atggagcggc tcaagactgt cgctgggtcc aagatgcaag gcttgctgga gcgcgtgaac 1380 acggagatac actttgtcac caaatgtgcc tttcagcccc cccccagctg tcttcgcttc 1440 gtccagacca acatctcccg cctcctgcag gagacctccg agcagctggt ggcgctgaag 1500 ccctggatca ctcgccagaa cttctcccgg tgcctggagc tgcagtgtca gcccgactcc 1560 tcaaccctg 1569 <210> 196 <211> 1380 <212> DNA <213> Homo sapiens <400> 196 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cactcaggac tgctcttttc aacacagccc catctcctcc 480 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 540 gtggcctcca acctgcagga cgaggagctc tgcgggggcc tctggcggct ggtcctggca 600 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 660 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccccc ccccagctgt 720 cttcgcttcg tccagaccaa catctcccgc ctcctgcagg agacctccga gcagctggtg 780 gcgctgaagc cctggatcac tcgccagaac ttctcccggt gcctggagct gcagtgtcag 840 cccgactcct caaccctgta cgtagagggc ggtggaggct ccccgggtga accgtctggt 900 ccaatctcta ctatcaaccc gtctcctccg tctaaagaat ctcataaatc tccaaacatg 960 gctacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 1020 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 1080 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 1140 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 1200 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 1260 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 1320 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 1380 1380 <210> 197 <211> 1569 <212> DNA <213> Homo sapiens <400> 197 gccactcagg actgctcttt tcaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 420 tacgtagagg gcggtggagg ctccccgggt gaaccgtctg gtccaatctc tactatcaac 480 ccgtctcctc cgtctaaaga atctcataaa tctccaaaca tggctacacc attgggccct 540 gccagctccc tgccccagag cttcctgctc aagtctttag agcaagtgag aaagatccag 600 ggcgatggcg cagcgctcca ggagaagctg tgtgccacct acaagctgtg ccaccccgag 660 gagctggtgc tgctcggaca ctctctgggc atcccctggg ctcccctgag ctcctgcccc 720 agccaggccc tgcagctggc aggctgcttg agccaactcc atagcggcct tttcctctac 780 caggggctcc tgcaggccct ggaagggata tcccccgagt tgggtcccac cttggacaca 840 ctgcagctgg acgtcgccga ctttgccacc accatctggc agcagatgga agaactggga 900 atggcccctg ccctgcagcc cacccagggt gccatgccgg ccttcgcctc tgctttccag 960 cgccgggcag gaggggtcct ggttgctagc catctgcaga gcttcctgga ggtgtcgtac 1020 cgcgttctac gccaccttgc gcagccctac gtagagggcg gtggaggctc cccgggtgaa 1080 ccgtctggtc caatctctac tatcaacccg tctcctccgt ctaaagaatc tcataaatct 1140 ccaaacatgg ctacccagga ctgctccttc caacacagcc ccatctcctc cgacttcgct 1200 gtcaaaatcc gtgagctgtc tgactacctg cttcaagatt acccagtcac cgtggcctcc 1260 aacctgcagg acgaggagct ctgcgggggc ctctggcggc tggtcctggc acagcgctgg 1320 atggagcggc tcaagactgt cgctgggtcc aagatgcaag gcttgctgga gcgcgtgaac 1380 acggagatac actttgtcac caaatgtgcc tttcagcccc cccccagctg tcttcgcttc 1440 gtccagacca acatctcccg cctcctgcag gagacctccg agcagctggt ggcgctgaag 1500 ccctggatca ctcgccagaa cttctcccgg tgcctggagc tgcagtgtca gcccgactcc 1560 tcaaccctg 1569 <210> 198 <211> 1003 <212> DNA <213> Homo sapiens <400> 198 ggccactcag gactgctctt ttcaacacag ccccatctcc tccgacttcg ctgtcaaaat 60 ccgtgagctg tctgactacc tgcttcaaga ttacccagtc accgtggcct ccaacctgca 120 ggacgaggag ctctgcgggg gcctctggcg gctggtcctg gcacagcgct ggatggagcg 180 gctcaagact gtcgctgggt ccaagatgca aggcttgctg gagcgcgtga acacggagat 240 acactttgtc accaaatgtg cctttcagcc cccccccagc tgtcttcgct tcgtccagac 300 caacatctcc cgcctcctgc aggagacctc cgagcagctg gtggcgctga agccctggat 360 cactcgccag aacttctccc ggtgcctgga gctgcagtgt cagcccgact cctcaaccct 420 gtacgtagag ggcggtggag gctccccggg tggtggttct ggcggcggct ccaacatggc 480 tacaccattg ggccctgcca gctccctgcc ccagagcttc ctgctcaagt ctttagagca 540 agtgagaaag atccagggcg atggcgcagc gctccaggag aagctgtgtg ccacctacaa 600 gctgtgccac cccgaggagc tggtgctgct cggacactct ctgggcatcc cctgggctcc 660 cctgagctcc tgccccagcc aggccctgca gctggcaggc tgcttgagcc aactccatag 720 cggccttttc ctctaccagg ggctcctgca ggccctggaa gggatatccc ccgagttggg 780 tcccaccttg gacacactgc agctggacgt cgccgacttt gccaccacca tctggcagca 840 gatggaagaa ctgggaatgg cccctgccct gcagcccacc cagggtgcca tgccggcctt 900 cgcctctgct ttccagcgcc gggcaggagg ggtcctggtt gctagccatc tgcagagctt 960 cctggaggtg tcgtaccgcg ttctacgcca ccttgcgcag ccg 1003 <210> 199 <211> 888 <212> DNA <213> Homo sapiens <400> 199 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagctctgcg ggggcctctg gcggctggtc ctggcacagc gctggatgga gcggctcaag 540 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 600 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 660 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 720 cagaacttct cccggtgcct ggagctgcag tgtcagcccg actcctcaac cctgggcggt 780 gggtcaggag gtggatccgg aggtacccag gactgctcct tccaacacag ccccatctcc 840 tccgacttcg ctgtcaaaat ccgtgagctg tctgactacc tgcttcaa 888 <210> 200 <211> 903 <212> DNA <213> Homo sapiens <400> 200 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagctctgcg ggggcctctg gcggctggtc ctggcacagc gctggatgga gcggctcaag 540 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 600 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 660 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 720 cagaacttct cccggtgcct ggagctgcag tgtcagcccg actcctcaac cctgggcggt 780 gggtcaggag gtgggtcagg aggtggatcc ggaggtggca cccaggactg ctccttccaa 840 cacagcccca tctcctccga cttcgctgtc aaaatccgtg agctgtctga ctacctgctt 900 caa 903 <210> 201 <211> 888 <212> DNA <213> Homo sapiens <400> 201 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgcctccaac ctgcaggacg aggagctctg cgggggcctc 480 tggcggctgg tcctggcaca gcgctggatg gagcggctca agactgtcgc tgggtccaag 540 atgcaaggct tgctggagcg cgtgaacacg gagatacact ttgtcaccaa atgtgccttt 600 cagccccccc ccagctgtct tcgcttcgtc cagaccaaca tctcccgcct cctgcaggag 660 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 720 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtgggtcagg aggtggatcc 780 ggaggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 840 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtg 888 <210> 202 <211> 903 <212> DNA <213> Homo sapiens <400> 202 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagaaggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgcctccaac ctgcaggacg aggagctctg cgggggcctc 480 tggcggctgg tcctggcaca gcgctggatg gagcggctca agactgtcgc tgggtccaag 540 atgcaaggct tgctggagcg cgtgaacacg gagatacact ttgtcaccaa atgtgccttt 600 cagccccccc ccagctgtct tcgcttcgtc cagaccaaca tctcccgcct cctgcaggag 660 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 720 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtgggtcagg aggtgggtca 780 ggaggtggat ccggaggtgg cacccaggac tgctccttcc aacacagccc catctcctcc 840 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 900 gtg 903 <210> 203 <211> 888 <212> DNA <213> Homo sapiens <400> 203 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 480 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 540 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 600 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 660 tcctcaaccc tgggcggtgg gtcaggaggt ggatccggag gtacccagga ctgctccttc 720 caacacagcc ccatctcctc cgacttcgct gtcaaaatcc gtgagctgtc tgactacctg 780 cttcaagatt acccagtcac cgtggcctcc aacctgcagg acgaggagct ctgcgggggc 840 ctctggcggc tggtcctggc acagcgctgg atggagcggc tcaagact 888 <210> 204 <211> 903 <212> DNA <213> Homo sapiens <400> 204 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc cgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 480 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 540 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 600 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 660 tcctcaaccc tgggcggtgg gtcaggaggt gggtcaggag gtggatccgg aggtggcacc 720 caggactgct ccttccaaca cagccccatc tcctccgact tcgctgtcaa aatccgtgag 780 ctgtctgact acctgcttca agattaccca gtcaccgtgg cctccaacct gcaggacgag 840 gagctctgcg ggggcctctg gcggctggtc ctggcacagc gctggatgga gcggctcaag 900 act 903 <210> 205 <211> 888 <212> DNA <213> Homo sapiens <400> 205 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ccgcttcgtc cagaccaaca tctcccgcct cctgcaggag 480 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 540 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtgggtcagg aggtggatcc 600 ggaggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 660 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 720 caggacgagg agctctgcgg gggcctctgg cggctggtcc tggcacagcg ctggatggag 780 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 840 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtctt 888 <210> 206 <211> 903 <212> DNA <213> Homo sapiens <400> 206 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ccgcttcgtc cagaccaaca tctcccgcct cctgcaggag 480 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 540 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtgggtcagg aggtgggtca 600 ggaggtggat ccggaggtgg cacccaggac tgctccttcc aacacagccc catctcctcc 660 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 720 gtggcctcca acctgcagga cgaggagctc tgcgggggcc tctggcggct ggtcctggca 780 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 840 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccccc ccccagctgt 900 ctt 903 <210> 207 <211> 888 <212> DNA <213> Homo sapiens <400> 207 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaagctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc caccaacatc tcccgcctcc tgcaggagac ctccgagcag 480 ctggtggcgc tgaagccctg gatcactcgc cagaacttct cccggtgcct ggagctgcag 540 tgtcagcccg actcctcaac cctgggcggt gggtcaggag gtggatccgg aggtacccag 600 gactgctcct tccaacacag ccccatctcc tccgacttcg ctgtcaaaat ccgtgagctg 660 tctgactacc tgcttcaaga ttacccagtc accgtggcct ccaacctgca ggacgaggag 720 ctctgcgggg gcctctggcg gctggtcctg gcacagcgct ggatggagcg gctcaagact 780 gtcgctgggt ccaagatgca aggcttgctg gagcgcgtga acacggagat acactttgtc 840 accaaatgtg cctttcagcc cccccccagc tgtcttcgct tcgtccag 888 <210> 208 <211> 903 <212> DNA <213> Homo sapiens <400> 208 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc caccaacatc tcccgcctcc tgcaggagac ctccgagcag 480 ctggtggcgc tgaagccctg gatcactcgc cagaacttct cccggtgcct ggagctgcag 540 tgtcagcccg actcctcaac cctgggcggt gggtcaggag gtgggtcagg aggtggatcc 600 ggaggtggca cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc 660 aaaatccgtg agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac 720 ctgcaggacg aggagctctg cgggggcctc tggcggctgg tcctggcaca gcgctggatg 780 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 840 gagatacact ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc 900 cag 903 <210> 209 <211> 921 <212> DNA <213> Homo sapiens <400> 209 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ttctaatctg caagatgaag agctgtgcgg gggcctctgg 480 cggctggtcc tggcacagcg ctggatggag cggctcaaga ctgtcgctgg gtccaagatg 540 caaggcttgc tggagcgcgt gaacacggag atacactttg tcaccaaatg tgcctttcag 600 ccccccccca gctgtcttcg cttcgtccag accaacatct cccgcctcct gcaggagacc 660 tccgagcagc tggtggcgct gaagccctgg atcactcgcc agaacttctc ccggtgcctg 720 gagctgcagt gtcagcccga ctcctcaacc ctgggcggtg ggtcaggagg tgggtcagga 780 ggtggatccg gaggtggctc agggggaggt agtggtaccc aggactgctc cttccaacac 840 agccccatct cctccgactt cgctgtcaaa atccgtgagc tgtctgacta cctgcttcaa 900 gattacccag tcaccgtggc c 921 <210> 210 <211> 921 <212> DNA <213> Homo sapiens <400> 210 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc caacctgcaa gatgaagagc tgtgtggggg cctctggcgg 480 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctgggtc caagatgcaa 540 ggcttgctgg agcgcgtgaa cacggagata cactttgtca ccaaatgtgc ctttcagccc 600 ccccccagct gtcttcgctt cgtccagacc aacatctccc gcctcctgca ggagacctcc 660 gagcagctgg tggcgctgaa gccctggatc actcgccaga acttctcccg gtgcctggag 720 ctgcagtgtc agcccgactc ctcaaccctg ggcggtgggt caggaggtgg gtcaggaggt 780 ggatccggag gtggctcagg gggaggtagt ggtacccagg actgctcctt ccaacacagc 840 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 900 tacccagtca ccgtggcctc c 921 <210> 211 <211> 921 <212> DNA <213> Homo sapiens <400> 211 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tctgcaggat gaggaactgt gcggcggcct ctggcggctg 480 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctgggtccaa gatgcaaggc 540 ttgctggagc gcgtgaacac ggagatacac tttgtcacca aatgtgcttt tcagcccccc 600 cccagctgtc ttcgcttcgt ccagaccaac atctcccgcc tcctgcagga gacctccgag 660 cagctggtgg cgctgaagcc ctggatcact cgccagaact tctcccggtg cctggagctg 720 cagtgtcagc ccgactcctc aaccctgggc ggtgggtcag gaggtgggtc aggaggtgga 780 tccggaggtg gctcaggggg aggtagtggt acccaggact gctccttcca acacagcccc 840 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 900 ccagtcaccg tggcctccaa c 921 <210> 212 <211> 921 <212> DNA <213> Homo sapiens <400> 212 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tcaagatgaa gagctgtgtg gtggtctctg gcggctggtc 480 ctggcacagc gctggatgga gcggctcaag actgtcgctg ggtccaagat gcaaggcttg 540 ctggagcgcg tgaacacgga gatacacttt gtcaccaaat gtgcctttca gccccccccc 600 agctgtcttc gcttcgtcca gaccaacatc tcccgcctcc tgcaggagac ctccgagcag 660 ctggtggcgc tgaagccctg gatcactcgc cagaacttct cccggtgcct ggagctgcag 720 tgtcagcccg actcctcaac cctgggcggt gggtcaggag gtgggtcagg aggtggatcc 780 ggaggtggct cagggggagg tagtggtacc caggactgct ccttccaaca cagccccatc 840 tcctccgact tcgctgtcaa aatccgtgag ctgtctgact acctgcttca agattaccca 900 gtcaccgtgg cctccaacct g 921 <210> 213 <211> 921 <212> DNA <213> Homo sapiens <400> 213 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tgaagaactg tgtggtggtc tgtggcggct ggtcctggca 480 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 540 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccccc ccccagctgt 600 cttcgcttcg tccagaccaa catctcccgc ctcctgcagg agacctccga gcagctggtg 660 gcgctgaagc cctggatcac tcgccagaac ttctcccggt gcctggagct gcagtgtcag 720 cccgactcct caaccctggg cggtgggtca ggaggtgggt caggaggtgg atccggaggt 780 ggctcagggg gaggtagtgg tacccaggac tgctccttcc aacacagccc catctcctcc 840 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaagatta cccagtcacc 900 gtggcctcca acctgcagga c 921 <210> 214 <211> 921 <212> DNA <213> Homo sapiens <400> 214 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tgagctgtgt ggtggcctgt ggcgtctggt cctggcacag 480 cgctggatgg agcggctcaa gactgtcgct gggtccaaga tgcaaggctt gctggagcgc 540 gtgaacacgg agatacactt tgtcaccaaa tgtgcctttc agcccccccc cagctgtctt 600 cgcttcgtcc agaccaacat ctcccgcctc ctgcaggaga cctccgagca gctggtggcg 660 ctgaagccct ggatcactcg ccaaaacttc tcccggtgcc tggagctgca gtgtcagccc 720 gactcctcaa ccctgggcgg tgggtcagga ggtgggtcag gaggtggatc cggaggtggc 780 tcagggggag gtagtggtac ccaggactgc tccttccaac acagccccat ctcctccgac 840 ttcgctgtca aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg 900 gcctccaacc tgcaggacga g 921 <210> 215 <211> 921 <212> DNA <213> Homo sapiens <400> 215 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tctgtgcggt ggtctgtggc gtctggtcct ggcacagcgc 480 tggatggagc ggctcaagac tgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 540 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 600 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 660 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 720 tcctcaaccc tgggcggtgg gtcaggaggt gggtcaggag gtggatccgg aggtggctca 780 gggggaggta gtggtaccca ggactgctcc ttccaacaca gccccatctc ctccgacttc 840 gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag attacccagt caccgtggcc 900 tccaacctgc aggacgagga g 921 <210> 216 <211> 921 <212> DNA <213> Homo sapiens <400> 216 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc ttctaatctg caagatgaag agctgtgcgg gggcctctgg 480 cggctggtcc tggcacagcg ctggatggag cggctcaaga ctgtcgctgg gtccaagatg 540 caaggcttgc tggagcgcgt gaacacggag atacactttg tcaccaaatg tgcctttcag 600 ccccccccca gctgtcttcg cttcgtccag accaacatct cccgcctcct gcaggagacc 660 tccgagcagc tggtggcgct gaagccctgg atcactcgcc agaacttctc ccggtgcctg 720 gagctgcagt gtcagcccga ctcctcaacc ctgggcggtg ggtcaggagg tgggtcagga 780 ggtggatccg gaggtggctc agggggaggt agtggtaccc aggactgctc cttccaacac 840 agccccatct cctccgactc cgctgtcaaa atccgtgagc tgtctgacta cctgcttcaa 900 gattacccag tcaccgtggc c 921 <210> 217 <211> 921 <212> DNA <213> Homo sapiens <400> 217 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tcaagatgaa gaactgtgcg gtggtctctg gcggctggtc 480 ctggcacagc gctggatgga gcggctcaag actgtcgctg ggtccaagat gcaaggcttg 540 ctggagcgcg tgaacacgga gatacacttt gtcaccaaat gtgcctttca gccccccccc 600 agctgtcttc gcttcgtcca gaccaacatc tcccgcctcc tgcgggagac ctccgagcag 660 ccggtggcgc tgaagccctg gatcactcgc cagaacttct cccggtgcct ggagctgcag 720 tgtcagcccg actcctcaac cctgggcggt gggtcaggag gtgggtcagg aggtggatcc 780 ggaggtggct cagggggagg tagtggtacc caggactgct ccttccaaca cagccccatc 840 tcctccgact tcgctgtcaa aatccgtgag ctgtctgact acctgcttca agattaccca 900 gtcaccgtgg cctccaacct g 921 <210> 218 <211> 921 <212> DNA <213> Homo sapiens <400> 218 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctaaccct 60 ttgctggacc cgaacaacct caattctgaa gacatggata tcctgatgga acgaaacctt 120 cgaactccaa acctgctcgc attcgtaagg gctgtcaagc acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tctgtgcggt ggtctgtggc gtctggtcct ggcacagcgc 480 tggatggagc ggctcaagac tgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 540 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 600 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 660 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcggcccgac 720 tcctcaaccc tgggcggtgg gtcaggaggt gggtcaggag gtggatccgg aggtggctca 780 gggggaggta gtggtaccca ggactgctcc ttccaacaca gccccatctc ctccgacttc 840 gctgtcaaga tccgtgagct gtctgactac ctgcttcaag attacccagt caccgtggcc 900 tccaacctgc aggacgagga g 921 <210> 219 <211> 906 <212> DNA <213> Homo sapiens <400> 219 gctgatgaag aactgtgtgg tggtctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtgta cgtagagggc 480 ggtggaggct ccccgggtga accgtctggt ccaatctcta ctatcaaccc gtctcctccg 540 tctaaagaat ctcataaatc tccaaacatg gctaactgct ctataatgat cgatgaaatt 600 atacatcact taaagagacc acctaaccct ttgctggacc cgaacaacct caattctgaa 660 gacatggata tcctgatgga acgaaacctt cgaactccaa acctgctcgc attcgtaagg 720 gctgtcaagc acttagaaaa tgcatcaggt attgaggcaa ttcttcgtaa tctccaacca 780 tgtctgccct ctgccacggc cgcaccctct cgacatccaa tcatcatcaa ggcaggtgac 840 tggcaagaat tccgggaaaa actgacgttc tatctggtta cccttgagca agcgcaggaa 900 caacag 906 <210> 220 <211> 888 <212> DNA <213> Homo sapiens <400> 220 gcggatgagg agctgtgcgg tggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaggccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tggatccgga ggtacccagg actgctcctt ccaacacagc 360 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 420 tacccagtca ccgtggcctc caacctgcag tacgtagagg gcggtggagg ctccccgggt 480 gaaccgtctg gtccaatctc tactatcaac ccgtctcctc cgtctaaaga atctcataaa 540 tctccaaaca tggctaactg ctctataatg atcgatgaaa ttatacatca cttaaagaga 600 ccacctaacc ctttgctgga cccgaacaac ctcaattctg aagacatgga tatcctgatg 660 gaacgaaacc ttcgaactcc aaacctgctc gcattcgtaa gggctgtcaa gcacttagaa 720 aatgcatcag gtattgaggc aattcttcgt aatctccaac catgtctgcc ctctgccacg 780 gccgcaccct ctcgacatcc aatcatcatc aaggcaggtg actggcaaga attccgggaa 840 aaactgacgt tctatctggt tacccttgag caagcgcagg aacaacag 888 <210> 221 <211> 903 <212> DNA <213> Homo sapiens <400> 221 gccgacgagg agctgtgcgg tggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggaac ccaggactgc 360 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 420 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgcagtacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct aactgctcta taatgatcga tgaaattata 600 catcacttaa agagaccacc taaccctttg ctggacccga acaacctcaa ttctgaagac 660 atggatatcc tgatggaacg aaaccttcga actccaaacc tgctcgcatt cgtaagggct 720 gtcaagcact tagaaaatgc atcaggtatt gaggcaattc ttcgtaatct ccaaccatgt 780 ctgccctctg ccacggccgc accctctcga catccaatca tcatcaaggc aggtgactgg 840 caagaattcc gggaaaaact gacgttctat ctggttaccc ttgagcaagc gcaggaacaa 900 cag 903 <210> 222 <211> 921 <212> DNA <213> Homo sapiens <400> 222 gcagacgagg agctgtgcgg tggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctaa ctgctctata 600 atgatcgatg aaattataca tcacttaaag agaccaccta accctttgct ggacccgaac 660 aacctcaatt ctgaagacat ggatatcctg atggaacgaa accttcgaac tccaaacctg 720 ctcgcattcg taagggctgt caagcactta gaaaatgcat caggtattga ggcaattctt 780 cgtaatctcc aaccatgtct gccctctgcc acggccgcac cctctcgaca tccaatcatc 840 atcaaggcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 900 gagcaagcgc aggaacaaca g 921 <210> 223 <211> 903 <212> DNA <213> Homo sapiens <400> 223 gcggacgagg agctgtgcgg tggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcctgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cctcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggaac ccaggactgc 360 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 420 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgcagtacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct aactgctcta taatgatcga tgaaattata 600 catcacttaa agagaccacc taaccctttg ctggacccga acaacctcaa ttctgaagac 660 atggatatcc tgatggaacg aaaccttcga actccaaacc tgctcgcatt cgtaagggct 720 gtcaagcact tagaaaatgc atcaggtatt gaggcaattc ttcgtaatct ccaaccatgt 780 ctgccctctg ccacggccgc accctctcga catccaatca tcatcaaggc aggtgactgg 840 caagaattcc gggaaaaact gacgttctat ctggttaccc ttgagcaagc gcaggaacaa 900 cag 903 <210> 224 <211> 921 <212> DNA <213> Homo sapiens <400> 224 gcggatgagg agctgtgtgg tggcctctgg cggctggtcc tggcacagcg ctggatgggg 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctaa ctgctctata 600 atgatcgatg aaattataca tcacttaaag agaccaccta accctttgct ggacccgaac 660 aacctcaatt ctgaagacat ggatatcctg atggaacgaa accttcgaac tccaaacctg 720 ctcgcattcg taagggctgt caagcactta gaaaatgcat caggtattga ggcaattctt 780 cgtaatctcc aaccatgtct gccctctgcc acggccgcac cctctcgaca tccaatcatc 840 atcaaggcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 900 gagcaagcgc aggaacaaca g 921 <210> 225 <211> 904 <212> DNA <213> Homo sapiens <400> 225 ggccgattac ccagtcaccg tggcctccaa cctgcaggac gaggagctct gcgggggcct 60 ctggcggctg gtcctggcac agcgctggat ggagcggctc aagactgtcg ctgggtccaa 120 gatgcaaggc ttgctggagc gcgtgaacac ggagatacac tttgtcacca aatgtgcctt 180 tcagcccccc cccagctgtc ttcgcttcgt ccagaccaac atctcccgcc tcctgcagga 240 gacctccgag cagctggtgg cgctgaagcc ctggatcact cgccagaact tctcccggtg 300 cctggagctg cagtgtcagc ccgactcctc aaccctgggc ggtgggtcag gaggtgggtc 360 aggaggtgga tccggaggtg gcacccagga ctgctccttc caacacagcc ccatctcctc 420 cgacttcgct gtcaaaatcc gtgagctgtc tgactacctg cttcaatacg tagagggcgg 480 tggaggctcc ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc 540 taaagaatct cataaatctc caaacatggc taactgctct ataatgatcg atgaaattat 600 acatcactta aagagaccac ctaacccttt gctggacccg aacaacctca attctgaaga 660 catggatatc ctgatggaac gaaaccttcg aactccaaac ctgctcgcat tcgtaagggc 720 tgtcaagcac ttagaaaatg catcaggtat tgaggcaatt cttcgtaatc tccaaccatg 780 tctgccctct gccacggccg caccctctcg acatccaatc atcatcaagg caggtgactg 840 gcaagaattc cgggaaaaac tgacgttcta tctggttacc cttgagcaag cgcaggaaca 900 acag 904 <210> 226 <211> 903 <212> DNA <213> Homo sapiens <400> 226 gccgcctcca acctgcagga cgaggagctc tgcgggggcc tctggcggct ggtcctggca 60 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 120 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccccc ccccagctgt 180 cttcgcttcg tccagaccaa catctcccgc ctcctgcagg agacctccga gcagctggtg 240 gcgctgaagc cctggatcac tcgccagaac ttctcccggt gcctggagct gcagtgtcag 300 cccgactcct caaccctggg cggtgggtca ggaggtgggt caggaggtgg atccggaggt 360 ggcacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 420 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtgtacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct aactgctcta taatgatcga tgaaattata 600 catcacttaa agagaccacc taaccctttg ctggacccga acaacctcaa ttctgaagac 660 atggatatcc tgatggaacg aaaccttcga actccaaacc tgctcgcatt cgtaagggct 720 gtcaagcact tagaaaatgc atcaggtatt gaggcaattc ttcgtaatct ccaaccatgt 780 ctgccctctg ccacggccgc accctctcga catccaatca tcatcaaggc aggtgactgg 840 caagaattcc gggaaaaact gacgttctat ctggttaccc ttgagcaagc gcaggaacaa 900 cag 903 <210> 227 <211> 903 <212> DNA <213> Homo sapiens <400> 227 gccgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 60 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 120 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 180 cagaacttct cccggtgcct ggagctgcag tgtcagcccg actcctcaac cctgggcggt 240 gggtcaggag gtgggtcagg aggtggatcc ggaggtggca cccaggactg ctccttccaa 300 cacagcccca tctcctccga cttcgctgtc aaaatccgtg agctgtctga ctacctgctt 360 caggattacc cagtcaccgt ggcctccaac ctgcaggacg aggagctctg cgggggcctc 420 tggcggctgg tcctggcaca gcgctggatg gagcggctca agacttacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct aactgctcta taatgatcga tgaaattata 600 catcacttaa agagaccacc taaccctttg ctggacccga acaacctcaa ttctgaagac 660 atggatatcc tgatggaacg aaaccttcga actccaaacc tgctcgcatt cgtaagggct 720 gtcaagcact tagaaaatgc atcaggtatt gaggcaattc ttcgtaatct ccaaccatgt 780 ctgccctctg ccacggccgc accctctcga catccaatca tcatcaaggc aggtgactgg 840 caagaattcc gggaaaaact gacgttctat ctggttaccc ttgagcaagc gcaggaacaa 900 cag 903 <210> 228 <211> 903 <212> DNA <213> Homo sapiens <400> 228 gcctccaaga tgcaaggctt gctggagcgc gtgaacacgg agatacactt tgtcaccaaa 60 tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc agaccaacat ctcccgcctc 120 ctgcaggaga cctccgagca gctggtggcg ctgaagccct ggatcactcg ccagaacttc 180 tcccggtgcc tggagctgca gtgtcagccc gactcctcaa ccctgggcgg tgggtcagga 240 ggtgggtcag gaggtggatc cggaggtggc acccaggact gctccttcca acacagcccc 300 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 360 ccagtcaccg tggcctccaa cctgcaggac gaggagctct gcgggggcct ctggcggctg 420 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctggctacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct aactgctcta taatgatcga tgaaattata 600 catcacttaa agagaccacc taaccctttg ctggacccga acaacctcaa ttctgaagac 660 atggatatcc tgatggaacg aaaccttcga actccaaacc tgctcgcatt cgtaagggct 720 gtcaagcact tagaaaatgc atcaggtatt gaggcaattc ttcgtaatct ccaaccatgt 780 ctgccctctg ccacggccgc accctctcga catccaatca tcatcaaggc aggtgactgg 840 caagaattcc gggaaaaact gacgttctat ctggttaccc ttgagcaagc gcaggaacaa 900 cag 903 <210> 229 <211> 903 <212> DNA <213> Homo sapiens <400> 229 gcccccccca gctgtcttcg cttcgtccag accaacatct cccgcctcct gcaggagacc 60 tccgagcagc tggtggcgct gaagccctgg atcactcgcc agaacttctc ccggtgcctg 120 gagctgcagt gtcagcccga ctcctcaacc ctgggcggtg ggtcaggagg tgggtcagga 180 ggtggatccg gaggtggcac ccaggactgc tccttccaac acagccccat ctcctccgac 240 ttcgctgtca aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg 300 gcctccaacc tgcaggacga ggagctctgc gggggcctct ggcggctggt cctggcacag 360 cgctggatgg agcggctcaa gactgtcgct gggtccaaga tgcaaggctt gctggagcgc 420 gtgaacacgg agatacactt tgtcaccaaa tgtgcctttc agccgtacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct aactgctcta taatgatcga tgaaattata 600 catcacttaa agagaccacc taaccctttg ctggacccga acaacctcaa ttctgaagac 660 atggatatcc tgatggaacg aaaccttcga actccaaacc tgctcgcatt cgtaagggct 720 gtcaagcact tagaaaatgc atcaggtatt gaggcaattc ttcgtaatct ccaaccatgt 780 ctgccctctg ccacggccgc accctctcga catccaatca tcatcaaggc aggtgactgg 840 caagaattcc gggaaaaact gacgttctat ctggttaccc ttgagcaagc gcaggaacaa 900 cag 903 <210> 230 <211> 903 <212> DNA <213> Homo sapiens <400> 230 gccaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 60 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 120 accctgggcg gtgggtcagg aggtgggtca ggaggtggat ccggaggtgg cacccaggac 180 tgctccttcc aacacagccc catctcctcc gacttygctg tcaaaatccg tgagctgtct 240 gactacctgc ttcaagatta cccagtcacc gtggcctcca acctgcagga cgaggagctc 300 tgcgggggcc tctggcggct ggtcctggca cagcgctgga tggagcggct caagactgtc 360 gctgggtcca agatgcaagg cttgctggag cgcgtgaaca cggagataca ctttgtcacc 420 aaatgtgcct ttcagccccc ccccagctgt cttcgcttcg tccagtacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct aactgctcta taatgatcga tgaaattata 600 catcacttaa agagaccacc taaccctttg ctggacccga acaacctcaa ttctgaagac 660 atggatatcc tgatggaacg aaaccttcga actccaaacc tgctcgcatt cgtaagggct 720 gtcaagcact tagaaaatgc atcaggtatt gaggcaattc ttcgtaatct ccaaccatgt 780 ctgccctctg ccacggccgc accctctcga catccaatca tcatcaaggc aggtgactgg 840 caagaattcc gggaaaaact gacgttctat ctggttaccc ttgagcaagc gcaggaacaa 900 cag 903 <210> 231 <211> 903 <212> DNA <213> Homo sapiens <400> 231 gcccgcttcg tccagaccaa catctcccgc ctcctgcagg agacctccga gcagctggtg 60 gcgctgaagc cctggatcac tcgccagaac ttctcccggt gcctggagct gcagtgtcag 120 cccgactcct caaccctggg cggtgggtca ggaggtgggt caggaggtgg atccggaggt 180 ggcacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 240 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 300 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 360 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg aacgcgtgaa cacggagata 420 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtttttacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct aactgctcta taatgatcga tgaaattata 600 catcacttaa agagaccacc taaccctttg ctggacccga acaacctcaa ttctgaagac 660 atggatatcc tgatggaacg aaaccttcga actccaaacc tgctcgcatt cgtaagggct 720 gtcaagcact tagaaaatgc atcaggtatt gaggcaattc ttcgtaatct ccaaccatgt 780 ctgccctctg ccacggccgc accctctcga catccaatca tcatcaaggc aggtgactgg 840 caagaattcc gggaaaaact gacgttctat ctggttaccc ttgagcaagc gcaggaacaa 900 cag 903 <210> 232 <211> 921 <212> DNA <213> Homo sapiens <400> 232 gcttcaaatc tgcaggatga agagctgtgc gggggcctct ggcggctggt cctggcacag 60 cgctggatgg agcggctcaa gactgtcgct gggtccaaga tgcaaggctt gctggagcgc 120 gtgaacacgg agatacactt tgtcaccaaa tgtgcctttc agcccccccc cagctgtctt 180 cgcttcgtcc agaccaacat ctcccgcctc ctgcaggaga cctccgagca gctggtggcg 240 ctgaagccct ggatcactcg ccagaacttc tcccggtgcc tggagctgca gtgtcagccc 300 gactcctcaa ccctgggcgg tgggtcagga ggtgggtcag gaggtggatc cggaggtggc 360 tcagggggag gtagtggtac ccaggactgc tccttccaac acagccccat ctcctccgac 420 ttcgctgtca aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg 480 gcctacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctaa ctgctctata 600 atgatcgatg aaattataca tcacttaaag agaccaccta accctttgct ggacccgaac 660 aacctcaatt ctgaagacat ggatatcctg atggaacgaa accttcgaac tccaaacctg 720 ctcgcattcg taagggctgt caagcactta gaaaatgcat caggtattga ggcaattctt 780 cgtaatctcc aaccatgtct gccctctgcc acggccgcac cctctcgaca tccaatcatc 840 atcaaggcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 900 gagcaagcgc aggaacaaca g 921 <210> 233 <211> 921 <212> DNA <213> Homo sapiens <400> 233 gctaatctgc aagatgagga gctgtgcggg ggcctctggc ggctggtcct ggcacagcgc 60 tggatggagc ggctcaagac tgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 120 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 180 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 240 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 300 tcctcaaccc tgggcggtgg gtcaggaggt gggtcaggag gtggatccgg aggtggctca 360 gggggaggta gtggtaccca ggactgctcc ttccaacaca gccccatctc ctccgacttc 420 gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag attacccagt caccgtggcc 480 tcctacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctaa ctgctctata 600 atgatcgatg aaattataca tcacttaaag agaccaccta accctttgct ggacccgaac 660 aacctcaatt ctgaagacat ggatatcctg atggaacgaa accttcgaac tccaaacctg 720 ctcgcattcg taagggctgt caagcactta gaaaatgcat caggtattga ggcaattctt 780 cgtaatctcc aaccatgtct gccctctgcc acggccgcac cctctcgaca tccaatcatc 840 atcaaggcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 900 gagcaagcgc aggaacaaca g 921 <210> 234 <211> 921 <212> DNA <213> Homo sapiens <400> 234 gcgctgcagg atgaagagct gtgtggcggc ctctggcggc tggtcctggc acagcgcttg 60 atggagcggc tcaagactgt cgctgggtcc aagatgcaag gcttgctgga gcgcgtgaac 120 acggagatac actttgtcac caaatgtgcc tttcagcccc cccccagctg tcttcgcttc 180 gtccagacca acatctcccg cctcctgcag gagacctccg agcagctggt ggcgctgaag 240 ccctggatca ctcgccagaa cttctcccgg tgcctggagc tgcagtgtca gcccgactcc 300 tcaaccctgg gcggtgggtc aggaggtggg tcaggaggtg gatccggagg tggctcaggg 360 ggaggtagtg gtacccagga ctgctccttc caacacagcc ccatctcctc cgacttcgct 420 gtcaaaatcc gtgagctgtc tgactacctg cttcaagatt acccagtcac cgtggcctcc 480 aactacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctaa ctgctctata 600 atgatcgatg aaattataca tcacttaaag agaccaccta accctttgct ggacccgaac 660 aacctcaatt ctgaagacat ggatatcctg atggaacgaa accttcgaac tccaaacctg 720 ctcgcattcg taagggctgt caagcactta gaaaatgcat caggtattga ggcaattctt 780 cgtaatctcc aaccatgtct gccctctgcc acggccgcac cctctcgaca tccaatcatc 840 atcaaggcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 900 gagcaagcgc aggaacaaca g 921 <210> 235 <211> 921 <212> DNA <213> Homo sapiens <400> 235 gcgcaagatg aggaactgtg tggtggtctc tggcggctgg tcctggcaca gcgctggatg 60 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 120 gagatacact ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc 180 cagaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 240 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 300 accctgggcg gtgggtcagg aggtgggtca ggaggtggat ccggaggtgg ctcaggggga 360 ggtagtggta cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc 420 aaaatccgtg agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac 480 ctgtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ccccgtctaa agaatctcat aaatctccaa acatggctaa ctgctctata 600 atgatcgatg aaattataca tcacttaaag agaccaccta accctttgct ggacccgaac 660 aacctcaatt ctgaagacat ggatatcctg atggaacgaa accttcgaac tccaaacctg 720 ctcgcattcg taagggctgt caagcactta gaaaatgcat caggtattga ggcaattctt 780 cgtaatctcc aaccatgtct gccctctgcc acggccgcac cctctcgaca tccaatcatc 840 atcaaggcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 900 gagcaagcgc aggaacaaca g 921 <210> 236 <211> 921 <212> DNA <213> Homo sapiens <400> 236 gctgaagaac tgtgtggtgg cctgtggcgg ctggtcctgg cacagcgctg gatggagcgg 60 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 120 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 180 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 240 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 300 ggcggtgggt caggaggtgg gtcaggaggt ggatccggag gtggctcagg gggaggtagt 360 ggtacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 420 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 480 gactacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctaa ctgctctata 600 atgatcgatg aaattataca tcacttaaag agaccaccta accctttgct ggacccgaac 660 aacctcaatt ctgaagacat ggatatcctg atggaacgaa accttcgaac tccaaacctg 720 ctcgcattcg taagggctgt caagcactta gaaaatgcat caggtattga ggcaattctt 780 cgtaatctcc aaccatgtct gccctctgcc acggccgcac cctctcgaca tccaatcatc 840 atcaaggcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 900 gagcaagcgc aggaacaaca g 921 <210> 237 <211> 921 <212> DNA <213> Homo sapiens <400> 237 gctctgtgcg gtggcctgtg gcgtctggtc ctggcacagc gctggatgga gcggctcaag 60 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 120 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 180 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 240 cagaacttct cccggtgcct ggagctgcag tgtcagcccg actcctcaac cctgggcggt 300 gggtcaggag gtgggtcagg aggtggatcc ggaggtggct cagggggagg tagtggtacc 360 caggactgct ccttccaaca cagccccatc tcctccgact tcgctgtcaa aatccgtgag 420 ctgtctgact acctgcttca agattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctaa ctgctctata 600 atgatcgatg aaattataca tcacttaaag agaccaccta accctttgct ggacccgaac 660 aacctcaatt ctgaagacat ggatatcctg atggaacgaa accttcgaac tccaaacctg 720 ctcgcattcg taagggctgt caagcactta gaaaatgcat caggtattga ggcaattctt 780 cgtaatctcc aaccatgtct gccctctgcc acggccgcac cctctcgaca tccaatcatc 840 atcaaggcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 900 gagcaagcgc aggaacaaca g 921 <210> 238 <211> 921 <212> DNA <213> Homo sapiens <400> 238 gcactgtgtg gtggtctgtg gcgtctggtc ctggcacagc gctggatgga gcggctcaag 60 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 120 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 180 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 240 cagaacttct cccggtgcct ggagctgcag tgtcagcccg actcctcaac cctgggcggt 300 gggtcaggag gtgggtcagg aggtggatcc ggaggtggct cagggggagg tagtggtacc 360 caggactgct ccttccaaca cagccccatc tcctccgact tcgctgtcaa aatccgtgag 420 ctgtctgact acctgcttca agattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctaa ctgctctata 600 atgatcgatg aaattataca tcacttaaag agaccaccta accctttgct ggacccgaac 660 aacctcaatt ctgaagacat ggatatcctg atggaacgaa accttcgaac tccaaacctg 720 ctcgcattcg taagggctgt caagcactta gaaaatgcat caggtattga ggcaattctt 780 cgtaatctcc aaccatgtct gccctctgcc acggccgcac cctctcgaca tccaatcatc 840 atcaaggcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 900 gagcaagcgc aggaacaaca g 921 <210> 239 <211> 921 <212> DNA <213> Homo sapiens <400> 239 gctctgtgtg gcggtctgtg gcgtctggtc ctggcacagc gctggatgga gcggctcaag 60 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 120 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 180 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 240 cagaacttct cccggtgcct ggagctgcag tgtcggcccg actcctcaac cctgggcggt 300 gggtcaggag gtgggtcagg aggtggatcc ggaggtggct cagggggagg tagtggtacc 360 caggactgct ccttccaaca cagccccatc tcctccgact tcgctgtcaa gatccgtgag 420 ctgtctgact acctgcttca agattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctaa ctgctctata 600 atgatcgatg aaattataca tcacttaaag agaccaccta accctttgct ggacccgaac 660 aacctcaatt ctgaagacat ggatatcctg atggaacgaa accttcgaac tccaaacctg 720 ctcgcattcg taagggctgt caagcactta gaaaatgcat caggtattga ggcaattctt 780 cgtaatctcc aaccatgtct gccctctgcc acggccgcac cctctcgaca tccaatcatc 840 atcaaggcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 900 gagcaagcgc aggaacaaca g 921 <210> 240 <211> 903 <212> DNA <213> Homo sapiens <400> 240 gcctccaaga tgcaaggctt gctggagcgc gtgaacacgg agatacactt tgtcaccaaa 60 tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc agaccaacat ctcccgcctc 120 ctgcaggaga cctccgagca gctggtggcg ctgaagccct ggatcactcg ccagaacttc 180 tcccggtgcc tggagctgca gtgtcagccc gactcctcaa ccctgggcgg tgggtcagga 240 ggtgggtcag gaggtggatc cggaggtggc acccaggact gctccttcca acacagcccc 300 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 360 ccagtcaccg tggcctccaa cctgcaggac gaggagctct gcgggggcct ctggcggctg 420 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctggctacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct aactgctcta taatgatcga tgaaattata 600 catcacttaa agagaccacc taaccctttg ctggacccga acaacctcaa ttctgaagac 660 atggatatcc tgatggaacg aaaccttcga actccaaacc tgctcgcatt cgtaagggct 720 gtcaagcact tagaaaatgc atcaggtatt gaggcaattc ttcgtaatct ccaaccatgt 780 ctgccctctg ccacggccgc accctctcga catccaatca tcatcaaggc aggtgactgg 840 caagaattcc gggaaaaact gacgttctat ctggttaccc ttgagcaagc gcaggaacaa 900 cag 903 <210> 241 <211> 945 <212> DNA <213> Homo sapiens <400> 241 gctcaagatg atgagctgtg tggtggtctc tggcggctgg tcctggcaca gcgctggatg 60 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 120 gagatacact ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc 180 cagaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 240 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 300 accctgggcg gtgggtcagg aggtgggtca ggcggtggtt ctggcggagg atccggcggc 360 ggaagcggag gtggctctgg gggaggtagt ggtacccagg actgctcctt ccaacacagc 420 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 480 tacccagtca ccgtggcctc caacctgtac gtagagggcg gtggaggctc cccgggtgaa 540 ccgtctggtc caatctctac tatcaacccg tctcctccgt ctaaagaatc tcataaatct 600 ccaaacatgg ctaactgctc tataatgatc gatgaaatta tacatcactt aaagagacca 660 cctaaccctt tgctggaccc gaacaacctc aattctgaag acatggatat cctgatggaa 720 cgaaaccttc gaactccaaa cctgctcgca ttcgtaaggg ctgtcaagca cttagaaaat 780 gcatcaggta ttgaggcaat tcttcgtaat ctccaaccat gtctgccctc tgccacggcc 840 gcaccctctc gacatccaat catcatcaag gcaggtgact ggcaagaatt ccgggaaaaa 900 ctgacgttct atctggttac ccttgagcaa gcgcaggaac aacag 945 <210> 242 <211> 903 <212> DNA <213> Homo sapiens <400> 242 gcccaagatg aagaactgtg tggtggcctc tggcggctgg tcctggcaca gcgctggatg 60 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 120 gagatacact ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc 180 cagaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 240 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 300 accctgccgc caccgtggag cccgcgtcca ctcggcgcca ccgcaccgac cacccaggac 360 tgctccttcc aacacagccc catctcctcc gacttcgctg tcaaaatccg tgagctgtct 420 gactacctgc ttcaagatta cccagtcacc gtggcctcca acctgtacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct aactgctcta taatgatcga tgaaattata 600 catcacttaa agagaccacc taaccctttg ctggacccga acaacctcaa ttctgaagac 660 atggatatcc tgatggaacg aaaccttcga actccaaacc tgctcgcatt cgtaagggct 720 gtcaagcact tagaaaatgc atcaggtatt gaggcaattc ttcgtaatct ccaaccatgt 780 ctgccctctg ccacggccgc accctctcga catccaatca tcatcaaggc aggtgactgg 840 caagaattcc gggaaaaact gacgttctat ctggttaccc ttgagcaagc gcaggaacaa 900 cag 903 <210> 243 <211> 921 <212> DNA <213> Homo sapiens <400> 243 gcccaagatg aagaactgtg tggtggcctc tggcggctgg tcctggcaca gcgctggatg 60 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 120 gagatacact ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc 180 cagaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 240 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 300 accctgccgc caccgtggag cccgcgtcca ctcggcgcca ccgcaccgac cgctggacaa 360 ccgcctctga cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc 420 aaaatccgtg agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac 480 ctgtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctaa ctgctctata 600 atgatcgatg aaattataca tcacttaaag agaccaccta accctttgct ggacccgaac 660 aacctcaatt ctgaagacat ggatatcctg atggaacgaa accttcgaac tccaaacctg 720 ctcgcattcg taagggctgt caagcactta gaaaatgcat caggtattga ggcaattctt 780 cgtaatctcc aaccatgtct gccctctgcc acggccgcac cctctcgaca tccaatcatc 840 atcaaggcag gtgactggca agaattccgg gaaaaactga cgttctatct ggttaccctt 900 gagcaagcgc aggaacaaca g 921 <210> 244 <211> 1110 <212> DNA <213> Homo sapiens <400> 244 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggct gatgaagaac tgtgtggtgg tctgtggcgg 660 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctgggtc caagatgcaa 720 ggcttgctgg agcgcgtgaa cacggagata cactttgtca ccaaatgtgc ctttcagccc 780 ccccccagct gtcttcgctt cgtccagacc aacatctccc gcctcctgca ggagacctcc 840 gagcagctgg tggcgctgaa gccctggatc actcgccaga acttctcccg gtgcctggag 900 ctgcagtgtc agcccgactc ctcaaccctg ggcggtgggt caggaggtgg gtcaggaggt 960 ggatccggag gtggctcagg gggaggtagt ggtacccagg actgctcctt ccaacacagc 1020 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 1080 tacccagtca ccgtggcctc caacctgcag 1110 <210> 245 <211> 1110 <212> DNA <213> Homo sapiens <400> 245 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggca aatctgcaag acgaggagct gtgcgggggc 660 ctctggcggc tggtcctggc acagcgctgg atggagcggc tcaagactgt cgctgggtcc 720 aagatgcaag gcttgctgga gcgcgtgaac acggagatac actttgtcac caaatgtgcc 780 tttcagcccc cccccagctg tcttcgcttc gtccagatca acatctcccg cctcctgcag 840 gagacctccg agcagctggt ggcgctgaag ccctggatca ctcgccagaa cttctcccgg 900 tgcctggagc tgcagtgtca gcccgactcc tcaaccctgg gcggtgggtc aggaggtggg 960 tcaggaggtg gatccggagg tggctcaggg ggaggtagtg gtacccagga ctgctccttc 1020 caacacagcc ccatctcctc cgacttcgct gtcaaaatcc gtgagctgtc tgactacctg 1080 cttcaagatt acccagtcac cgtggcctcc 1110 <210> 246 <211> 1110 <212> DNA <213> Homo sapiens <400> 246 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggcc ccccccagct gtcttcgctt cgtccagacc 660 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 720 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 780 ggcggtgggt caggaggtgg gtcaggaggt ggatccggag gtggctcagg gggaggtagt 840 ggtacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 900 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 960 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 1020 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 1080 cactttgtca ccaaatgtgc ctttcagccc 1110 <210> 247 <211> 1110 <212> DNA <213> Homo sapiens <400> 247 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggct ctgcaggatg aggaactgtg cggcggcctc 660 tggcggctgg tcctggcaca gcgctggatg gagcggctca agactgtcgc tgggtccaag 720 atgcaaggct tgctggagcg cgtgaacacg gagatacact ttgtcaccaa atgtgccttt 780 cagccccccc ccagctgtct tcgcttcgtc cagaccaaca tctcccgcct cctgcaggag 840 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 900 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtgggtcagg aggtgggtca 960 ggaggtggat ccggaggtgg ctcaggggga ggtagtggta cccaggactg ctccttccaa 1020 cacagcccca tctcctccga cttcgctgtc aaaatccgtg agctgtctga ctacctgctt 1080 caagattacc cagtcaccgt ggcctccaac 1110 <210> 248 <211> 1110 <212> DNA <213> Homo sapiens <400> 248 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggct caagatgaag agctgtgtgg tggtctctgg 660 cggctggtcc tggcacagcg ctggatggag cggctcaaga ctgtcgctgg gtccaagatg 720 caaggcttgc tggagcgcgt gaacacggag atacactttg tcaccaaatg tgcctttcag 780 ccccccccca gctgtcttcg cttcgtccag accaacatct cccgcctcct gcaggagacc 840 tccgagcagc tggtggcgct gaagccctgg atcactcgcc agaacttctc ccggtgcctg 900 gagctgcagt gtcagcccga ctcctcaacc ctgggcggtg ggtcaggagg tgggtcagga 960 ggtggatccg gaggtggctc agggggaggt agtggtaccc aggactgctc cttccaacac 1020 agccccatct cctccgactt cgctgtcaaa atccgtgagc tgtctgacta cctgcttcaa 1080 gattacccag tcaccgtggc ctccaacctg 1110 <210> 249 <211> 1110 <212> DNA <213> Homo sapiens <400> 249 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggct gaagaactgt gtggtggtct gtggcggctg 660 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctgggtccaa gatgcaaggc 720 ttgctggagc gcgtgaacac ggagatacac tttgtcacca aatgtgcctt tcagcccccc 780 cccagctgtc ttcgcttcgt ccagaccaac atctcccgcc tcctgcagga gacctccgag 840 cagctggtgg cgctgaagcc ctggatcact cgccagaact tctcccggtg cctggagctg 900 cagtgtcagc ccgactcctc aaccctgggc ggtgggtcag gaggtgggtc aggaggtgga 960 tccggaggtg gctcaggggg aggtagtggt acccaggact gctccttcca acacagcccc 1020 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 1080 ccagtcaccg tggcctccaa cctgcaggac 1110 <210> 250 <211> 1110 <212> DNA <213> Homo sapiens <400> 250 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggct gagctgtgtg gtggcctgtg gcgtctggtc 660 ctggcacagc gctggatgga gcggctcaag actgtcgctg ggtccaagat gcaaggcttg 720 ctggagcgcg tgaacacgga gatacacttt gtcaccaaat gtgcctttca gccccccccc 780 agctgtcttc gcttcgtcca gaccaacatc tcccgcctcc tgcaggagac ctccgagcag 840 ctggtggcgc tgaagccctg gatcactcgc cagaacttct cccggtgcct ggagctgcag 900 tgtcagcccg actcctcaac cctgggcggt gggtcaggag gtgggtcagg aggtggatcc 960 ggaggtggct cagggggagg tagtggtacc caggactgct ccttccaaca cagccccatc 1020 tcctccgact tcgctgtcaa aatccgtgag ctgtctgact acctgcttca agattaccca 1080 gtcaccgtgg cctccaacct gcaggacgag 1110 <210> 251 <211> 1110 <212> DNA <213> Homo sapiens <400> 251 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggct ctgtgcggtg gtctgtggcg tctggtcctg 660 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 720 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 780 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 840 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 900 cagcccgact cctcaaccct gggcggtggg tcaggaggtg ggtcaggagg tggatccgga 960 ggtggctcag ggggaggtag tggtacccag gactgctcct tccaacacag ccccatctcc 1020 tccgacttcg ctgtcaaaat ccgtgagctg tctgactacc tgcttcaaga ttacccagtc 1080 accgtggcct ccaacctgca ggacgaggag 1110 <210> 252 <211> 1092 <212> DNA <213> Homo sapiens <400> 252 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggct gatgaagaac tgtgtggtgg gctgtggcgg 660 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctgggtc caagatgcaa 720 ggcttgctgg agcgcgtgaa cacggagata cactttgtca ccaaatgtgc ctttcagccc 780 ccccccagct gtcttcgctt cgtccagacc aacatctccc gcctcctgca ggagacctcc 840 gagcagctgg tggcgctgaa gccctggatc actcgccaga acttctcccg gtgcctggag 900 ctgcagtgtc agcccgactc ctcaaccctg ccgccaccgt ggagcccgcg tccactcggc 960 gccaccgcac cgaccaccca ggactgctcc ttccaacaca gccccatctc ctccgacttc 1020 gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag attacccagt caccgtggcc 1080 tccaacctgc ag 1092 <210> 253 <211> 1134 <212> DNA <213> Homo sapiens <400> 253 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggct gatgaagaac tgtgtggtgg gctgtggcgg 660 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctgggtc caagatgcaa 720 ggcttgctgg agcgcgtgaa cacggagata cactttgtca ccaaatgtgc ctttcagccc 780 ccccccagct gtcttcgctt cgtccagacc aacatctccc gcctcctgca ggagacctcc 840 gagcagctgg tggcgctgaa gccctggatc actcgccaga acttctcccg gtgcctggag 900 ctgcagtgtc agcccgactc ctcaaccctg ggcggtgggt caggaggtgg gtcaggcggt 960 ggttctggcg gaggatccgg cggcggaagc ggaggtggct ctgggggagg tagtggtacc 1020 caggactgct ccttccaaca cagccccatc tcctccgact tcgctgtcaa aatccgtgag 1080 ctgtctgact acctgcttca agattaccca gtcaccgtgg cctccaacct gcag 1134 <210> 254 <211> 1110 <212> DNA <213> Homo sapiens <400> 254 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggct gatgaagaac tgtgtggtgg gctgtggcgg 660 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctgggtc caagatgcaa 720 ggcttgctgg agcgcgtgaa cacggagata cactttgtca ccaaatgtgc ctttcagccc 780 ccccccagct gtcttcgctt cgtccagacc aacatctccc gcctcctgca ggagacctcc 840 gagcagctgg tggcgctgaa gccctggatc actcgccaga acttctcccg gtgcctggag 900 ctgcagtgtc agcccgactc ctcaaccctg ccgccaccgt ggagcccgcg tccactcggc 960 gccaccgcac cgaccgctgg acaaccgcct ctgacccagg actgctcctt ccaacacagc 1020 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 1080 tacccagtca ccgtggcctc caacctgcag 1110 <210> 255 <211> 465 <212> DNA <213> Homo sapiens <400> 255 gccgattacc cagtcaccgt ggcctccaac ctgcaggacg aggagctctg cgggggcctc 60 tggcggctgg tcctggcaca gcgctggatg gagcggctca agactgtcgc tgggtccaag 120 atgcaaggct tgctggagcg cgtgaacacg gagatacact ttgtcaccaa atgtgccttt 180 cagccccccc ccagctgtct tcgcttcgtc cagaccaaca tctcccgcct cctgcaggag 240 acctccgagc agctggtggc gctgaagccc tggatcactc gccagaactt ctcccggtgc 300 ctggagctgc agtgtcagcc cgactcctca accctgggcg gtgggtcagg aggtgggtca 360 ggaggtggat ccggaggtgg cacccaggac tgctccttcc aacacagccc catctcctcc 420 gacttcgctg tcaaaatccg tgagctgtct gactacctgc ttcaa 465 <210> 256 <211> 465 <212> DNA <213> Homo sapiens <400> 256 gccgcctcca acctgcagga cgaggagctc tgcgggggcc tctggcggct ggtcctggca 60 cagcgctgga tggagcggct caagactgtc gctgggtcca agatgcaagg cttgctggag 120 cgcgtgaaca cggagataca ctttgtcacc aaatgtgcct ttcagccccc ccccagctgt 180 cttcgcttcg tccagaccaa catctcccgc ctcctgcagg agacctccga gcagctggtg 240 gcgctgaagc cctggatcac tcgccagaac ttctcccggt gcctggagct gcagtgtcag 300 cccgactcct caaccctggg cggtgggtca ggaggtgggt caggaggtgg atccggaggt 360 ggcacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 420 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtg 465 <210> 257 <211> 465 <212> DNA <213> Homo sapiens <400> 257 gccgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 60 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 120 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 180 cagaacttct cccggtgcct ggagctgcag tgtcagcccg actcctcaac cctgggcggt 240 gggtcaggag gtgggtcagg aggtggatcc ggaggtggca cccaggactg ctccttccaa 300 cacagcccca tctcctccga cttcgctgtc aaaatccgtg agctgtctga ctacctgctt 360 caagattacc cagtcaccgt ggcctccaac ctgcaggacg aggagctctg cgggggcctc 420 tggcggctgg tcctggcaca gcgctggatg gagcggctca agact 465 <210> 258 <211> 465 <212> DNA <213> Homo sapiens <400> 258 gcctccaaga tgcaaggctt gctggagcgc gtgaacacgg agatacactt tgtcaccaaa 60 tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc agaccaacat ctcccgcctc 120 ctgcaggaga cctccgagca gctggtggcg ctgaagccct ggatcactcg ccagaacttc 180 tcccggtgcc tggagctgca gtgtcagccc gactcctcaa ccctgggcgg tgggtcagga 240 ggtgggtcag gaggtggatc cggaggtggc acccaggact gctccttcca acacagcccc 300 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 360 ccagtcaccg tggcctccaa cctgcaggac gaggagctct gcgggggcct ctggcggctg 420 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctggg 465 <210> 259 <211> 465 <212> DNA <213> Homo sapiens <400> 259 gcccccccca gctgtcttcg cttcgtccag accaacatct cccgcctcct gcaggagacc 60 tccgagcagc tggtggcgct gaagccctgg atcactcgcc agaacttctc ccggtgcctg 120 gagctgcagt gtcagcccga ctcctcaacc ctgggcggtg ggtcaggagg tgggtcagga 180 ggtggatccg gaggtggcac ccaggactgc tccttccaac acagccccat ctcctccgac 240 ttcgctgtca aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg 300 gcctccaacc tgcaggacga ggagctctgc gggggcctct ggcggctggt cctggcacag 360 cgctggatgg agcggctcaa gactgtcgct gggtccaaga tgcaaggctt gctggagcgc 420 gtgaacacgg agatacactt tgtcaccaaa tgtgcctttc agccc 465 <210> 260 <211> 465 <212> DNA <213> Homo sapiens <400> 260 gcccgcttcg tccagaccaa catctcccgc ctcctgcagg agacctccga gcagctggtg 60 gcgctgaagc cctggatcac tcgccagaac ttctcccggt gcctggagct gcagtgtcag 120 cccgactcct caaccctggg cggtgggtca ggaggtgggt caggaggtgg atccggaggt 180 ggcacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 240 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 300 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 360 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 420 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtctt 465 <210> 261 <211> 465 <212> DNA <213> Homo sapiens <400> 261 gccaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 60 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 120 accctgggcg gtgggtcagg aggtgggtca ggaggtggat ccggaggtgg cacccaggac 180 tgctccttcc aacacagccc catctcctcc gacttcgctg tcaaaatccg tgagctgtct 240 gactacctgc ttcaagatta cccagtcacc gtggcctcca acctgcagga cgaggagctc 300 tgcgggggcc tctggcggct ggtcctggca cagcgctgga tggagcggct caagactgtc 360 gctgggtcca agatgcaagg cttgctggag cgcgtgaaca cggagataca ctttgtcacc 420 aaatgtgcct ttcagccccc ccccagctgt cttcgcttcg tccag 465 <210> 262 <211> 1110 <212> DNA <213> Homo sapiens <400> 262 gctgatgaag aactgtgtgg tggtctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattgggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtctt tagagcaagt gagaaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttc tacgccacct tgcgcagccc 1110 <210> 263 <211> 1110 <212> DNA <213> Homo sapiens <400> 263 gcagatgaag aactgtgtgg gggactgtgg cgtctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttc tacgccacct tgcgcagccc 1110 <210> 264 <211> 1062 <212> DNA <213> Homo sapiens <400> 264 gctgatgaag aactgtgtgg tgggctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgccgccac cgtggagccc gcgtccactc ggcgccaccg caccgaccgc tggacaaccg 360 cctctgaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 tacgtagagg gcggtggagg ctccccgggt ggtggttctg gcggcggctc caacatggct 540 acaccattgg gccctgccag ctccctgccc cagagcttcc tgctcaagtc tttagagcaa 600 gtgaggaaga tccagggcga tggcgcagcg ctccaggaga agctgtgtgc cacctacaag 660 ctgtgccacc ccgaggagct ggtgctgctc ggacactctc tgggcatccc ctgggctccc 720 ctgagctcct gccccagcca ggccctgcag ctggcaggct gcttgagcca actccatagc 780 ggccttttcc tctaccaggg gctcctgcag gccctggaag ggatatcccc cgagttgggt 840 cccaccttgg acacactgca gctggacgtc gccgactttg ccaccaccat ctggcagcag 900 atggaagaac tgggaatggc ccctgccctg cagcccaccc agggtgccat gccggccttc 960 gcctctgctt tccagcgccg ggcaggaggg gtcctggttg ctagccatct gcagagcttc 1020 ctggaggtgt cgtaccgcgt tctacgccac cttgcgcagc cg 1062 <210> 265 <211> 1089 <212> DNA <213> Homo sapiens <400> 265 gctgatgaag aactgtgtgg tgggctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcaggc ggtggttctg gcggaggatc cggcggcgga 360 agcggaggtg gctctggggg aggtagtggt acccaggact gctccttcca acacagcccc 420 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 480 ccagtcaccg tggcctccaa cctgcagtac gtagagggcg gtggaggctc cccgggtggt 540 ggttctggcg gcggctccaa catggctaca ccattgggcc ctgccagctc cctgccccag 600 agcttcctgc tcaagtcttt agagcaagtg aggaagatcc agggcgatgg cgcagcgctc 660 caggagaagc tgtgtgccac ctacaagctg tgccaccccg aggagctggt gctgctcgga 720 cactctctgg gcatcccctg ggctcccctg agctcctgcc ccagccaggc cctgcagctg 780 gcaggctgct tgagccaact ccatagcggc cttttcctct accaggggct cctgcaggcc 840 ctggaaggga tatcccccga gttgggtccc accttggaca cactgcagct ggacgtcgcc 900 gactttgcca ccaccatctg gcagcagatg gaagaactgg gaatggcccc tgccctgcag 960 cccacccagg gtgccatgcc ggccttcgcc tctgctttcc agcgccgggc aggaggggtc 1020 ctggttgcta gccatctgca gagcttcctg gaggtgtcgt accgcgttct acgccacctt 1080 gcgcagccg 1089 <210> 266 <211> 1044 <212> DNA <213> Homo sapiens <400> 266 gctgatgaag aactgtgtgg tgggctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgccgccac cgtggagccc gcgtccactc ggcgccaccg caccgaccac ccaggactgc 360 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 420 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgtacgtaga gggcggtgga 480 ggctccccgg gtggtggttc tggcggcggc tccaacatgg ctacaccatt gggccctgcc 540 agctccctgc cccagagctt cctgctcaag tctttagagc aagtgagraa gatccagggc 600 gatggcgcag cgctccagga gaagctgtgt gccacctaca agctgtgcca ccccgaggag 660 ctggtgctgc tcggacactc tctgggcatc ccctgggctc ccctgagctc ctgccccagc 720 caggccctgc agctggcagg ctgcttgagc caactccata gcggcctttt cctctaccag 780 gggctcctgc aggccctgga agggatatcc cccgagttgg gtcccacctt ggacacactg 840 cagctggacg tcgccgactt tgccaccacc atctggcagc agatggaaga actgggaatg 900 gcccctgccc tgcagcccac ccagggtgcc atgccggcct tcgcctctgc tttccagcgc 960 cgggcaggag gggtcctggt tgctagccat ctgcagagct tcctggaggt gtcgtaccgc 1020 gttctacgcc accttgcgca gccg 1044 <210> 267 <211> 1077 <212> DNA <213> Homo sapiens <400> 267 gcggatgagg agctgtgcgg tggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaggccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tggatccgga ggtacccagg actgctcctt ccaacacagc 360 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 420 tacccagtca ccgtggcctc caacctgcag tacgtagagg gcggtggagg ctccccgggt 480 gaaccgtctg gtccaatctc tactatcaac ccgtctcctc cgtctaaaga atctcataaa 540 tctccaaaca tggctacacc attaggccct gccagctccc tgccccagag cttcctgctc 600 aagtgcttag agcaagtgag gaagatccag ggcgatggcg cagcgctcca ggagaagctg 660 tgtgccacct acaagctgtg ccaccccgag gagctggtgc tgctcggaca ctctctgggc 720 atcccctggg ctcccctgag ctcctgcccc agccaggccc tgcagctggc aggctgcttg 780 agccaactcc atagcggcct tttcctctac caggggctcc tgcaggccct ggaagggata 840 tcccccgagt tgggtcccac cttggacaca ctgcagctgg acgtcgccga ctttgccacc 900 accatctggc agcagatgga agaactggga atggcccctg ccctgcagcc cacccagggt 960 gccatgccgg ccttcgcctc tgctttccag cgccgggcag gaggggtcct ggttgctagc 1020 catctgcaga gcttcctgga ggtgtcgtac cgcgttctac gccaccttgc gcagccc 1077 <210> 268 <211> 1092 <212> DNA <213> Homo sapiens <400> 268 gccgacgagg agctgtgcgg tggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggcac ccaggactgc 360 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 420 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgcagtacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct acaccattag gccctgccag ctccctgccc 600 cagagcttcc tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg 660 ctccaggaga agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc 720 ggacactctc tgggcatccc ctgggctccc ctgagctcct gccccagcca ggccctgcag 780 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag 840 gccctggaag ggatatcccc cgagttgggt cccaccttgg acacactgca gctggacgtc 900 gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg 960 cagcccaccc agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg 1020 gtcctggttg ctagccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac 1080 cttgcgcagc cc 1092 <210> 269 <211> 1110 <212> DNA <213> Homo sapiens <400> 269 gcagacgagg agctgtgcgg tggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttg tacgccacct tgcgcagccc 1110 <210> 270 <211> 1092 <212> DNA <213> Homo sapiens <400> 270 gcccccccca gctgtcttcg cttcgtccag accaacatct cccgcctcct gcaggagacc 60 tccgagcagc tggtggcgct gaagccctgg atcactcgcc agaacttctc ccggtgcctg 120 gagctgcagt gtcagcccga ctcctcaacc ctgggcggtg ggtcaggagg tgggtcagga 180 ggtggatccg gaggtggcac ccaggactgc tccttccaac acagccccat ctcctccgac 240 ttcgctgtca aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg 300 gcctccaacc tgcaggacga ggagctctgc gggggcctct ggcggctggt cctggcacag 360 cgctggatgg agcggctcaa gactgtcgct gggtccaaga tgcaaggctt gctggagcgc 420 gtgaacacgg agatacactt tgtcaccaaa tgtgcctttc agccgtacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct acaccattag gccctgccag ctccgtgccc 600 cagagcttcc tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg 660 ctccaggaga agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc 720 ggacactctc tgggcatccc ctgggctccc ctgagctcct gccccagcca ggccctgcag 780 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag 840 gccctggaag ggatatcccc cgagttgggt cccaccttgg acacactgca gctggacgtc 900 gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg 960 cagcccaccc agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg 1020 gtcctggttg ctagccatct gcagagcttc ctggaggtgt cgtaccgcgt tatacgccac 1080 cttgcgcagc cc 1092 <210> 271 <211> 1110 <212> DNA <213> Homo sapiens <400> 271 gcttcaaatc tgcaggatga agagctgtgc gggggcctct ggcggctggt cctggcacag 60 cgctggatgg agcggctcaa gactgtcgct gggtccaaga tgcaaggctt gctggagcgc 120 gtgaacacgg agatacactt tgtcaccaaa tgtgcctttc agcccccccc cagctgtctt 180 cgcttcgtcc agaccaacat ctcccgcctc ctgcaggaga cctccgagca gctggtggcg 240 ctgaagccct ggatcactcg ccagaacttc tcccggtgcc tggagctgca gtgtcagccc 300 gactcctcaa ccctgggcgg tgggtcagga ggtgggtcag gaggtggatc cggaggtggc 360 tcagggggag gtagtggtac ccaggactgc tccttccaac acagccccat ctcctccgac 420 ttcgctgtca aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg 480 gcctacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc atccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttc tacgccacct tgcgcagccc 1110 <210> 272 <211> 1110 <212> DNA <213> Homo sapiens <400> 272 gctaatctgc aagatgagga gctgtgcggg ggcctctggc ggctggtcct ggcacagcgc 60 tggatggagc ggctcaagac tgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 120 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 180 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 240 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 300 tcctcaaccc tgggcggtgg gtcaggaggt gggtcaggag gtggatccgg aggtggctca 360 gggggaggta gtggtaccca ggactgctcc ttccaacaca gccccatctc ctccgacttc 420 gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag attacccagt caccgtggcc 480 tcctacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgtta tacgccacct tgcgcagccc 1110 <210> 273 <211> 1110 <212> DNA <213> Homo sapiens <400> 273 gcgctgcagg atgaagagct gtgtggcggc ctctggcggc tggtcctggc acagcgcttg 60 atggagcggc tcaagactgt cgctgggtcc aagatgcaag gcttgctgga gcgcgtgaac 120 acggagatac actttgtcac caaatgtgcc tttcagcccc cccccagctg tcttcgcttc 180 gtccagacca acatctcccg cctcctgcag gagacctccg agcagctggt ggcgctgaag 240 ccctggatca ctcgccagaa cttctcccgg tgcctggagc tgcagtgtca gcccgactcc 300 tcaaccctgg gcggtgggtc aggaggtggg tcaggaggtg gatccggagg tggctcaggg 360 ggaggtagtg gtacccagga ctgctccttc caacacagcc ccatctcctc cgacttcgct 420 gtcaaaatcc gtgagctgtc tgactacctg cttcaagatt acccagtcac cgtggcctcc 480 aactacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttc tacgccacct tgcgcagccc 1110 <210> 274 <211> 1110 <212> DNA <213> Homo sapiens <400> 274 gcactgtgcg gtggtctgtg gcgtctggtc ctggcacagc gctggatgga gcggctcaag 60 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 120 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 180 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 240 cagaacttct cccggtgcct ggagctacag tgtcagcccg actcctcaac cctgggcggt 300 gggtcaggag gtgggtcagg aggtggatcc ggaggtggct cagggggagg tagtggtacc 360 caggactgct ccttccaaca cagccccatc tcctccgact tcgctgtcaa aatccgtgag 420 ctgtctgact acctgcttca agattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttc tacgccacct tgcgcagccc 1110 <210> 275 <211> 1092 <212> DNA <213> Homo sapiens <400> 275 gcctccaaga tgcaaggctt gctggagcgc gtgaacacgg agatacactt tgtcaccaaa 60 tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc agaccaacat ctcccgcctc 120 ctgcaggaga cctccgagca gctggtggcg ctgaagccct ggatcactcg ccagaacttc 180 tcccggtgcc tggagctgca gtgtcagccc gactcctcaa ccctgggcgg tgggtcagga 240 ggtgggtcag gaggtggatc cggaggtggc acccaggact gctccttcca acacagcccc 300 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 360 ccagtcaccg tggcctccaa cctgcaggac gaggagctct gcgggggcct ctggcggctg 420 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctggctacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct acaccattag gccctgccag ctccctgccc 600 cagagcttcc tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg 660 ctccaggaga agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc 720 ggacactctc tgggcatccc ctgggctccc ctgagctcct gccccagcca ggccctgcag 780 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag 840 gccctggaag ggatatcccc cgagttgggt cccaccttgg acacactgca gctggacgtc 900 gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg 960 cagcccaccc agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg 1020 gtcctggttg ctagccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac 1080 cttgcgcagc cc 1092 <210> 276 <211> 1092 <212> DNA <213> Homo sapiens <400> 276 gcctccaaga tgcaaggctt gctggagcgc gtgaacacgg agatacactt tgtcaccaaa 60 tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc agaccaacat ctcccgcctc 120 ctgcaggaga cctccgagca gctggtggcg ctgaagccct ggatcactcg ccagaacttc 180 tcccggtgcc tggagctgca gtgtcagccc gactcctcaa ccctgggcgg tgggtcagga 240 ggtgggtcag gaggtggatc cggaggtggc acccaggact gctccttcca acacagcccc 300 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 360 ccagtcaccg tggcctccaa cctgcaggac gaggagctct gcgggggcct ctggcggctg 420 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctggctacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct acaccattag gccctgccag ctccctgccc 600 cagagcttcc tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg 660 ctccaggaga agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc 720 ggacactctc tgggcatccc ctgggctccc ctgagctcct gccccagcca ggccctgcag 780 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag 840 gccctggaag ggatatcccc cgagttgggt cccaccttgg acacactgca gctggacgtc 900 gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg 960 cagcccaccc agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg 1020 gtcctggttg ctagccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac 1080 cttgcgcagc cc 1092 <210> 277 <211> 1110 <212> DNA <213> Homo sapiens <400> 277 gcgctgtgtg gtggtctgtg gcgtctggtc ctggcacagc gctggatgga gcggctcaag 60 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 120 gtcaccaaat gtgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 180 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 240 cagaacttct cccggtgcct ggagctgcag tgtcggcccg actcctcaac cctgggcggt 300 gggtcaggag gtgggtcagg aggtggatcc ggaggtggct cagggggagg tagtggtacc 360 caggactgct ccttccaaca cagccccatc tcctccaact tcgctgtcaa gatccgtgag 420 ctgtctgact acctgcttca agattaccca gtcaccgtgg cctccaacct gcaggacgag 480 gagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ttttactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttc tacgccacct tgcgcagccc 1110 <210> 278 <211> 1110 <212> DNA <213> Homo sapiens <400> 278 gctgaactgt gtggtggtct gtggcgtctg gtcctggcac agcgctggat ggagcggctc 60 aagactgtcg ctgggtccaa gatgcaaggc ttgctggagc gcgtgaacac ggagatacac 120 tttgtcacca aatgtgcctt tcagcccccc cccagctgtc ttcgcttcgt ccagaccaac 180 atctcccgcc tcctgcagga gacctccgag cagctggtgg cgctgaagcc ctggatcact 240 cgccagaact tctcccggtg cctggagctg cagtgtcagc ccgactcctc aaccctgggc 300 ggtgggtcag gaggtgggtc aggaggtgga tccggaggtg gctcaggggg aggtagtggt 360 acccaggact gctccttcca acacagcccc atctcctccg acttcgctgt caaaatccgt 420 gagctgtctg actacctgct tcaagattac ccagtcaccg tggcctccaa cctgcaggac 480 gagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttc tacgccacct tgcgcagccc 1110 <210> 279 <211> 1110 <212> DNA <213> Homo sapiens <400> 279 gctgaagaac tgtgtggtgg cctgtggcgg ctggtcctgg cacagcgctg gatggagcgg 60 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 120 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 180 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 240 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 300 ggcggtgggt caggaggtgg gtcaggaggt ggatccggag gtggctcagg gggaggtagt 360 ggtacccagg actgctcctt ccaacacagc cccatctcct ccgacttcgc tgtcaaaatc 420 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 480 gactacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttc tacgccacct tgcgcagccc 1110 <210> 280 <211> 1110 <212> DNA <213> Homo sapiens <400> 280 gctcaggacg aggaactgtg tggtggtctc tggcggctgg tcctggcaca gcgctggatg 60 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 120 gagatacact ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc 180 cagaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 240 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 300 accctgggcg gtgggtcagg aggtgggtca ggaggtggat ccggaggtgg ctcaggggga 360 ggtagtggta cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc 420 aaaatccgtg agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac 480 ctgtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttc tacgccacct tgcgcagccc 1110 <210> 281 <211> 1092 <212> DNA <213> Homo sapiens <400> 281 gccaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 60 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 120 accctgggcg gtgggtcagg aggtgggtca ggaggtggat ccggaggtgg cacccaggac 180 tgctccttcc aacacagccc catctcctcc gactttgctg tcaaaatccg tgagctgtct 240 gactacctgc ttcaagatta cccagtcacc gtggcctcca acctgcagga cgaggagctc 300 tgcgggggcc tctggcggct ggtcctggca cagcgctgga tggagcggct caagactgtc 360 gctgggtcca agatgcaagg cttgctggag cgcgtgaaca cggagataca ctttgtcacc 420 aaatgtgcct ttcagccccc ccccagctgt cttcgcttcg tccagtacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct acaccattag gccctgccag ctccctgccc 600 cagagcttcc tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg 660 ctccaggaga agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc 720 ggacactctc tgggcatccc ctgggctccc ctgagctcct gccccagcca ggccctgcag 780 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag 840 gccctggaag ggatatcccc cgagttgggt cccaccttgg acacactgca gctggacgtc 900 gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg 960 cagcccaccc agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg 1020 gtcctggttg ctagccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac 1080 cttgcgcagc cc 1092 <210> 282 <211> 1065 <212> DNA <213> Homo sapiens <400> 282 gctgatgaag aactgtgtgg tggtctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggctccccg ggtggtggtt ctggcggcgg ctccaacatg 540 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 600 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 660 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 720 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 780 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 840 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 900 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 960 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 1020 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccg 1065 <210> 283 <211> 1110 <212> DNA <213> Homo sapiens <400> 283 gctcaagatg aagaactgtg cggtggtctc tggcggctgg tcctggcaca gcgctggatg 60 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 120 gagatacact ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc 180 cagaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 240 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 300 accctgggcg gtgggtcagg aggtgggtca ggaggcggat ccggaggtgg ctcaggggga 360 ggtagtggta cccaggactg ctccttccaa cacagcccca tctcctccga ctccgctgtc 420 aaaatccgtg agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac 480 ctgtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttc tacgccacct tgcgcagccc 1110 <210> 284 <211> 1098 <212> DNA <213> Homo sapiens <400> 284 gcgctgtgtg gtggcctgtg gcgtctggtc ctggcacagc gctggatgga gcggctcaag 60 actgtcgctg ggtccaagat gcaaggcttg ctggagcgcg tgaacacgga gatacacttt 120 gtcaccaaat atgcctttca gccccccccc agctgtcttc gcttcgtcca gaccaacatc 180 tcccgcctcc tgcaggagac ctccgagcag ctggtggcgc tgaagccctg gatcactcgc 240 cagaacttct cccggtgcct ggagctgcag tgtcggcccg actcctcaac cctgggcggt 300 gggtcaggag gtggatccgg aggtggctca gggggaggta gtggtaccca ggactgctcc 360 ttccaacaca gccccatctc ctccgacttc gctgtcaaga tccgtgagct gtctgactac 420 ctgcttcaag attacccagt caccgtggcc tccaacctgc aggacgagga gtacgtagag 480 ggcggtggag gctccccggg tgaaccgtct ggtccaatct ctactatcaa cccgtctcct 540 ccgtctaaag aatctcataa atctccaaac atggctacac cattaggccc tgccagctcc 600 ctgccccaga gcttcctgct caagtgctta gagcaagtga ggaagatcca gggcgatggc 660 gcagcgctcc aggagaagct gtgtgccacc tacaagctgt gccaccccga ggagctggtg 720 ctgctcggac actctctggg catcccctgg gctcccctga gctcctgccc cagccaggcc 780 ctgcagctgg caggctgctt gagccaactc catagcggcc ttttcctcta ccaggggctc 840 ctgcaggccc tggaagggat atcccccgag ttgggtccca ccttggacac actgcagctg 900 gacgtcgccg actttgccac caccatctgg cagcagatgg aagaactggg aatggcccct 960 gccctgcagc ccacccaggg tgccatgccg gccttcgcct ctgctttcca gcgccgggca 1020 ggaggggtcc tggttgctag ccatctgcag agcttcctgg aggtgtcgta ccgcgttcta 1080 cgccaccttg cgcagccc 1098 <210> 285 <211> 1092 <212> DNA <213> Homo sapiens <400> 285 gcctccaaga tgcaaggctt gctggagcgc gtgaacacgg agatacactt tgtcaccaaa 60 tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc agaccaacat ctcccgcctc 120 ctgcaggaga cctccgagca gctggtggcg ctgaagccct ggatcactcg ccagaacttc 180 ttccggtgcc tggagctgca gtgtcagccc gactcctcaa ccctgggcgg tgggtcagga 240 ggtgggtcag gaggtggatc cggaggtggc acccaggact gctccttcca acacagcccc 300 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 360 ccagtcaccg tggcctccaa cctgcaggac gaggagctct gcgggggcct ctggcggctg 420 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctggctacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct acaccattag gccctgccag ctccctgccc 600 cagagcttcc tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg 660 ctccaggaga agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc 720 ggacactctc tgggcatccc ctgggctccc ctgagctcct gccccagcca ggccctgcag 780 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag 840 gccctggaag ggatatcccc cgagttgggt cccaccttgg acacactgca gctggacgtc 900 gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg 960 cagcccaccc agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg 1020 gtcctggttg ctagccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac 1080 cttgcgcagc cc 1092 <210> 286 <211> 1134 <212> DNA <213> Homo sapiens <400> 286 gctcaagacg aagaactgtg tggtggtctc tggcggctgg tcctggcaca gcgctggatg 60 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 120 gagatacact ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc 180 cagaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 240 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 300 accctgggcg gtgggtcagg aggtgggtca ggcggtggtt ctggcggagg atccggcggc 360 ggaagcggag gtggctctgg gggaggtagt ggtacccagg actgctcctt ccaacacagc 420 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 480 tacccagtca ccgtggcctc caacctgtac gtagagggcg gtggaggctc cccgggtgaa 540 ccgtctggtc caatctctac tatcaacccg tctcctccgt ctaaagaatc tcataaatct 600 ccaaacatgg ctacaccatt aggccctgcc agctccctgc cccagagctt cctgctcaag 660 tgcttagagc aagtgaggaa gatccagggc gatggcgcag cgctccagga gaagctgtgt 720 gccacctaca agctgtgcca ccccgaggag ctggtgctgc tcggacactc tctgggcatc 780 ccctgggctc ccctgagctc ctgccccagc caggccctgc agctggcagg ctgcttgagc 840 caactccata gcggcctttt cctctaccag gggctcctgc aggccctgga agggatatcc 900 cccgagttgg gtcccacctt ggacacactg cagctggacg tcgccgactt tgccaccacc 960 atctggcagc agatggaaga actgggaatg gcccctgccc tgcagcccac ccagggtgcc 1020 atgccggcct tcgcctctgc tttccagcgc cgggcaggag gggtcctggt tgctagccat 1080 ctgcagagct tcctggaggt gtcgtaccgc gttctacgcc accttgcgca gccc 1134 <210> 287 <211> 1092 <212> DNA <213> Homo sapiens <400> 287 gcccaagatg aagaactgtg tggtggcctc tggcggctgg tcctggcaca gcgctggatg 60 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 120 gagatacact ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc 180 cagaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 240 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 300 accctgccgc caccgtggag cccgcgtcca ctcggcgcca ccgcaccgac cacccaggac 360 tgctccttcc aacacagccc catctcctcc gacttcgctg tcaaaatccg tgagctgtct 420 gactacctgc ttcaagatta cccagtcacc gtggcctcca acctgtacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct acaccattag gccctgccag ctccctgccc 600 cagagcttcc tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg 660 ctccaggaga agctgtgtgc cacctacaag ctgtgccacc ccgaggagct ggtgctgctc 720 ggacactctc tgggcatccc ctgggctccc ctgagctcct gccccagcca ggccctgcag 780 ctggcaggct gcttgagcca actccatagc ggccttttcc tctaccaggg gctcctgcag 840 gccctggaag ggatatcccc cgagttgggt cccaccttgg acacactgca gctggacgtc 900 gccgactttg ccaccaccat ctggcagcag atggaagaac tgggaatggc ccctgccctg 960 cagcccaccc agggtgccat gccggccttc gcctctgctt tccagcgccg ggcaggaggg 1020 gtcctggttg ctagccatct gcagagcttc ctggaggtgt cgtaccgcgt tctacgccac 1080 cttgcgcagc cc 1092 <210> 288 <211> 1110 <212> DNA <213> Homo sapiens <400> 288 gcccaagatg aagaactgtg tggtggcctc tggcggctgg tcctggcaca gcgctggatg 60 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 120 gagatacact ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc 180 cagaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 240 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 300 accctgccgc caccgtggag cccgcgtcca ctcggcgcca ccgcaccgac cgctggacaa 360 ccgcctctga cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc 420 aaaatccgtg agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac 480 ctgtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttc tacgccacct tgcgcagccc 1110 <210> 289 <211> 1134 <212> DNA <213> Homo sapiens <400> 289 gctgatgaag aactgtgtgg tgggctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcaggc ggtggttctg gcggaggatc cggcggcgga 360 agcggaggtg gctctggggg aggtagtggt acccaggact gctccttcca acacagcccc 420 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 480 ccagtcaccg tggcctccaa cctgcagtac gtagagggcg gtggaggctc cccgggtgaa 540 ccgtctggtc caatctctac tatcaacccg tctcctccgt ctaaagaatc tcataaatct 600 ccaaacatgg ctacaccatt aggccctgcc agctccctgc cccagagctt cctgctcaag 660 tgcttagagc aagtgaggaa gatccagggc gatggcgcag cgctccagga gaagctgtgt 720 gccacctaca agctgtgcca ccccgaggag ctggtgctgc tcggacactc tctgggcatc 780 ccctgggctc ccctgagctc ctgccccagc caggccctgc agctggcagg ctgcttgagc 840 caactccata gcggcctttt cctctaccag gggctcctgc aggccctgga agggatatcc 900 cccgagttgg gtcccacctt ggacacactg cagctggacg tcgccgactt tgccaccacc 960 atctggcagc agatggaaga actgggaatg gcccctgccc tgcagcccac ccagggtgcc 1020 atgccggcct tcgcctctgc tttccagcgc cgggcaggag gggtcctggt tgctagccat 1080 ctgcagagct tcctggaggt gtcgtaccgc gttctacgcc accttgcgca gccc 1134 <210> 290 <211> 1134 <212> DNA <213> Homo sapiens <400> 290 gctgatgaag aactgtgtgg tgggctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggcccaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcaggc ggtggttctg gcggaggatc cggcggcgga 360 agcggaggtg gctctggggg aggtagtggt acccaggact gctccttcca acacagcccc 420 atctcctccg acttcgctgt caaaatccgt gagctgtctg actacctgct tcaagattac 480 ccagtcaccg tggcctccaa cctgcagtac gtagagggcg gtggaggctc cccgggtgaa 540 ccgtctggtc caatctctac tatcaacccg tctcctccgt ctaaagaatc tcataaatct 600 ccaaacatgg ctacaccatt aggccctgcc agctccctgc cccagagctt cctgctcaag 660 tgcttagagc aagtgaggaa gatccagggc gatggcgcag cgctccagga gaagctgtgt 720 gccacctaca agctgtgcca ccccgaggag ctggtgctgc tcggacactc tctgggcatc 780 ccctgggctc ccctgagctc ctgccccagc caggccctgc agctggcagg ctgcttgagc 840 caactccata gcggcctttt cctctaccag gggctcctgc aggccctgga agggatatcc 900 cccgagttgg gtcccacctt ggacacactg cagctggacg tcgccgactt tgccaccacc 960 atctggcagc agatggaaga actgggaatg gcccctgccc tgcagcccac ccagggtgcc 1020 atgccggcct tcgcctctgc tttccagcgc cgggcaggag gggtcctggt tgctagccat 1080 ctgcagagct tcctggaggt gtcgtaccgc gttctacgcc accttgcgca gccc 1134 <210> 291 <211> 1110 <212> DNA <213> Homo sapiens <400> 291 gcggacgagg agctgtgcgg tggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgccgccac cgtggagccc gcgtccactc ggcgccaccg caccgaccgc tggacaaccg 360 cctctgaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggcaccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 600 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 660 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 720 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 780 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 840 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 900 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 960 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1020 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1080 taccgcgttc tacgccacct tgcgcagccc 1110 <210> 292 <211> 1041 <212> DNA <213> Homo sapiens <400> 292 gctgatgagg agctgtgtgg tggtctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccgt agagacggtg 300 tttcaccgtg tcagccagga tggtctagat ctcctgacct cgacccagga ctgctccttc 360 caacacagcc ccatctcctc cgacttcgct gtcaaaatcc gtgagctgtc tgactacctg 420 cttcaagatt acccagtcac cgtggcctcc aacctgcagt acgtagaggg cggtggaggc 480 tccccgggtg gtggttctgg cggcggctcc aacatggcta caccattggg ccctgccagc 540 tccctgcccc agagcttcct gctcaagtct ttagagcaag tgagaaagat ccagggcgat 600 ggcgcagcgc tccaggagaa gctgtgtgcc actaacaagc tgtgccaccc cgaggagctg 660 gtgctgctcg gacactctct gggcatcccc tgggctcccc tgagctcctg ccccagccag 720 gccctgcagc tggcaggctg cttgagccaa ctccatagcg gccttttcct ctaccagggg 780 ctcctgcagg ccctggaagg gatatccccc gagttgggtc ccaccttgga cacactgcag 840 ctggacgtcg ccgactttgc caccaccatc tggcagcaga tggaagaact gggaatggcc 900 cctgccctgc agcccaccca gggtgccatg ccggccttcg cctctgcttt ccagcgccgg 960 gcaggagggg tcctggttgc tagccatctg cagagcttcc tggaggtgtc gtaccgcgtt 1020 ctacgccacc ttgcgcagcc g 1041 <210> 293 <211> 1152 <212> DNA <213> Homo sapiens <400> 293 gctgatgaag aactgtgtgg tgggctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 360 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattgggc 420 cctgccagct ccctgcccca gagcttcctg ctcaagtctt tagagcaagt gagaaagatc 480 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 540 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 600 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 660 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 720 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 780 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 840 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 900 taccgcgttc tacgccacct tgcgcagccc tacgtagagg gcggtggagg ctccccgggt 960 gaaccgtctg gtccaatctc tactatcaac ccgtctcctc cgtctaaaga atctcataaa 1020 tctccaaaca tggcaaccca ggactgctct tttcaacaca gccccatctc ctccgacttc 1080 gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag attacccagt caccgtggcc 1140 tccaacctgc ag 1152 <210> 294 <211> 1047 <212> DNA <213> Homo sapiens <400> 294 gccacccagg actgctcctt tcaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gagccgaaga gcccggacac ccatactagt ccgccatctc cgacaccatt aggccctgcc 180 agctccctgc cccagagctt cctgctcaag tctttagagc aagtgagaaa gatccagggc 240 gatggcgcag cgctccagga gaagctgtgt gccacctaca agctgtgcca ccccgaggag 300 ctggtgctgc tcggacactc tctgggcatc ccctgggctc ccctgagctc ctgccccagc 360 caggccctgc agctggcagg ctgcttgagc caactccata gcggcctttt cctctaccag 420 gggctcctgc aggccctgga agggatatcc cccgagttgg gccccacctt ggacacactg 480 cagctggacg tcgccgactt tgccaccacc atctggcagc agatggaaga actgggaatg 540 gcccctgccc tgcagcccac ccagggtgcc atgccggcct tcgcctctgc tttccagcgc 600 cgggcaggag gggtcctggt tgctagccat ctgcagagct tcctggaggt gtcgtaccgc 660 gttctacgcc accttgcgca gccctctgca gaaccgaaat ctccggatac tcataccagc 720 ccgccatccc cgggttctaa tctgcaagat gaagagctgt gcgggggcct ctggcggctg 780 gtcctggcac agcgctggat ggagcggctc aagactgtcg ctgggtccaa gatgcaaggc 840 ttgctggagc gcgtgaacac ggagatacac tttgtcacca aatgtgcctt tcagcccccc 900 cccagctgcc ttcgcttcgt ccagaccaac atctcccgcc tcctgcagga gacctccgag 960 cagctggtgg cgctgaagcc ctggatcact cgccagaact tctcccggtg cctggagctg 1020 cagtgtcagc ccgactcctc aaccctg 1047 <210> 295 <211> 1043 <212> DNA <213> Homo sapiens <400> 295 gccacccagg actgctcctt tcaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggctggcagg ggcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttccgaag agcccggaca cccatactag tccgccatct 300 ccgggtacac cattgggccc tgccagctcc ctgccccaga gcttcctgct caagtcttta 360 gagcaagtga gaaagatcca gggcgatggc gcagcgctcc aggagaagct gtgtgccact 420 acaagctgtg ccaccccgag gagctggtgc tgctcggaca ctctctgggc atcccctggg 480 ctcccctgag ctcctgcccc agccaggccc tgcagctggc aggctgcttg agccaactcc 540 atagcggcct tttcctctac caggggctcc tgcaggccct ggaagggata tcccccgagt 600 tgggtcccac cttggacaca ctgcagctgg acgtcgccga ctttgccacc accatctggc 660 agcagatgga agaactggga atggcccctg ccctgcagcc cacccagggt gccatgccgg 720 ccttcgcctc tgctttccag cgccgggcag gaggggtcct ggttgctagc catctgcaga 780 gcttcctgga ggtgtcgtac cgcgttctac gccaccttgc gcagccctct gcagaaccga 840 aatctccgga tactcatacc agcccgccat ccccgggtaa ggcctttcag ccccccccca 900 gctgtcttcg cttcgtccag accaacatct cccgcctcct gcaggagacc tccgagcagc 960 tggtggcgct gaagccctgg atcactcgcc agaacttctc ccggtgcctg gagctgcagt 1020 gtcagcccga ctcctcaacc ctg 1043 <210> 296 <211> 1065 <212> DNA <213> Homo sapiens <400> 296 gctgatgaag aactgtgtgg tggtctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatc tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactcctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggctccccg ggtggtggtt ctggcggcgg ctccaacatg 540 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 600 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccactaac 660 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 720 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 780 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 840 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 900 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 960 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 1020 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccg 1065 <210> 297 <211> 1110 <212> DNA <213> Homo sapiens <400> 297 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggct gatgaagaac tgtgtggtgg tctgtggcgg 660 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctgggtc caagatgcaa 720 ggcttgctgg agcgcgtgaa cacggagata cactttgtca ccaaatctgc ctttcagccc 780 ccccccagct gtcttcgctt cgtccagacc aacatctccc gcctcctgca ggagacctcc 840 gagcagctgg tggcgctgaa gccctggatc actcgccaga acttctcccg gtgcctggag 900 ctgcagtgtc agcccgactc ctcaaccctg ggcggtgggt caggaggtgg gtcaggaggt 960 ggatccggag gtggctcagg gggaggtagt ggtacccagg actcctcctt ccaacacagc 1020 cccatctcct ccgacttcgc tgtcaaaatc cgcgagctgt ctgactacct gcttcaagat 1080 tacccagtca ccgtggcctc caacctgcag 1110 <210> 298 <211> 1065 <212> DNA <213> Homo sapiens <400> 298 gctgatgaag aactgtgtgg tggtctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctctcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgccta gagctgcagt ctcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggctccccg ggtggtggtt ctggcggcgg ctccaacatg 540 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 600 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccactaac 660 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 720 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 780 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 840 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 900 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 960 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 1020 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccg 1065 <210> 299 <211> 1110 <212> DNA <213> Homo sapiens <400> 299 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggca gatgaagaac tgtgtggggg cctgtggcgg 660 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctgggtc caagatgcaa 720 ggcttgctgg agcgcgtgaa cacggagata cactttgtca ccaaatgtgc ctttcagccc 780 ccccccagct ctcttcgctt cgtccagacc aacatctccc gcctcctgca ggagacctcc 840 gagcagctgg tggcgctgaa gccctggatc actcgccaga acttctcccg gtgcctggag 900 ctgcagtctc agcccgactc ctcaaccctg ggcggtgggt caggaggtgg gtcaggaggt 960 ggatccggag gtggctcagg gggaggtagt ggtactcagg actgttcttt tcaacacagc 1020 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 1080 tacccagtca ccgtggcctc caacctgcag 1110 <210> 300 <211> 1002 <212> DNA <213> Homo sapiens <400> 300 gccactcagg actcctcttt tcaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatctgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 420 tacgtagagg gcggtggagg ctccccgggt ggtggttctg gcggcggctc caacatggct 480 acaccattgg gccctgccag ctccctgccc cagagcttcc tgctcaagtc tttagagcaa 540 gtgagaaaga tccagggcga tggcgcagcg ctccaggaga agctgtgtgc cactaacaag 600 ctgtgccacc ccgaggagct ggtgctgctc ggacactctc tgggcatccc ctgggctccc 660 ctgagctcct gccccagcca ggccctgcag ctggcaggct gcttgagcca actccatagc 720 ggccttttcc tctaccaggg gctcctgcag gccctggaag ggatatcccc cgagttgggt 780 cccaccttgg acacactgca gctggacgtc gccgactttg ccaccaccat ctggcagcag 840 atggaagaac tgggaatggc ccctgccctg cagcccaccc agggtgccat gccggccttc 900 gcctctgctt tccagcgccg ggcaggaggg gtcctggttg ctagccatct gcagagcttc 960 ctggaggtgt cgtaccgcgt tctacgccac cttgcgcagc cg 1002 <210> 301 <211> 1002 <212> DNA <213> Homo sapiens <400> 301 gccactcagg actgttcttt tcaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct ctcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtctc agcccgactc ctcaaccctg 420 tacgtagagg gcggtggagg ctccccgggt ggtggttctg gcggcggctc caacatggct 480 acaccattgg gccctgccag ctccctgccc cagagcttcc tgctcaagtc tttagagcaa 540 gtgagaaaga tccagggcga tggcgcagcg ctccaggaga agctgtgtgc cacctacaag 600 ctgtgccacc ccgaggagct ggtgctgctc ggacactctc tgggcatccc ctgggctccc 660 ctgagctcct gccccagcca ggccctgcag ctggcaggct gcttgagcca actccatagc 720 ggccttttcc tctaccaggg gctcctgcag gccctggaag ggatatcccc cgagttgggt 780 cccaccttgg acacactgca gctggacgtc gccgactttg ccaccaccat ctggcagcag 840 atggaagaac tgggaatggc ccctgccctg cagcccaccc agggtgccat gccggccttc 900 gcctctgctt tccagcgccg ggcaggaggg gtcctggttg ctagccatct gcagagcttc 960 ctggaggtgt cgtaccgcgt tctacgccac cttgcgcagc cg 1002 <210> 302 <211> 978 <212> DNA <213> Homo sapiens <400> 302 gccactcagg actgttcttt tcaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtacg tagagggcgg tggaggctcc 420 ccgggtggtg gttctggcgg cggctccaac atggctacac cattgggccc tgccagctcc 480 ctgccccaga gcttcctgct caagtcttta gagcaagtga gaaagatcca gggcgatggc 540 gcagcgctcc aggagaagct gtgtgccact aacaagctgt gccaccccga ggagctggtg 600 ctgctcggac actctctggg catcccctgg gctcccctga gctcctgccc cagccaggcc 660 ctgcagctgg caggctgctt gagccaactc catagcggcc ttttcctcta ccaggggctc 720 ctgcaggccc tggaagggat atcccccgag ttgggtccca ccttggacac actgcagctg 780 gacgtcgccg actttgccac caccatctgg cagcagatgg aagaactggg aatggcccct 840 gccctgcagc ccacccaggg tgccatgccg gccttcgcct ctgctttcca gcgccgggca 900 ggaggggtcc tggttgctag ccatctgcag agcttcctgg aggtgtcgta ccgcgttcta 960 cgccaccttg cgcagccg 978 <210> 303 <211> 1002 <212> DNA <213> Homo sapiens <400> 303 gccactcagg actgttcttt tcaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtctc agcccgactc ctcaaccctg 420 tacgtagagg gcggtggagg ctccccgggt ggtggttctg gcggcggctc caacatggct 480 acaccattgg gccctgccag ctccctgccc cagagcttcc tgctcaagtc tttagagcaa 540 gtgagaaaga tccagggcga tggcgcagcg ctccaggaga agctgtgtgc cacctacaag 600 ctgtgccacc ccgaggagct ggtgctgctc ggacactctc tgggcatccc ctgggctccc 660 ctgagctcct gccccagcca ggccctgcag ctggcaggct gcttgagcca actccatagc 720 ggccttttcc tctaccaggg gctcctgcag gccctggaag ggatatcccc cgagttgggt 780 cccaccttgg acacactgca gctggacgtc gccgactttg ccaccaccat ctggcagcag 840 atggaagaac tgggaatggc ccctgccctg cagcccaccc agggtgccat gccggccttc 900 gcctctgctt tccagcgccg ggcaggaggg gtcctggttg ctagccatct gcagagcttc 960 ctggaggtgt cgtaccgcgt tctacgccac cttgcgcagc cg 1002 <210> 304 <211> 1001 <212> DNA <213> Homo sapiens <400> 304 gccactcagg actgttcttt tcaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gcgcctggag ctgcagtctc agcccgactc ctcaaccctg 420 tacgtagagg gcggtggagg ctccccgggt ggtggttctg gcggcggctc caacatggct 480 acaccattgg gccctgccag ctccctgccc cagagcttcc tgctcaagtc tttagagcaa 540 gtgagaaaga tccagggcga tggcgcagcg ctccaggaga agctgtgtgc cactaacaag 600 ctgtgccacc ccgaggagct ggtgctgctc ggacactctc tgggcatccc ctgggctccc 660 ctgagctcct gccccagcca ggccctgcag ctggcaggct gcttgagcca actccatagc 720 ggccttttcc tctaccaggg gctcctgcag gccctggaag ggatatcccc cgagttgggt 780 cccaccttgg acacactgca gctggacgtc gccgactttg ccaccaccat ctggcagcag 840 atggaagaac tgggaatggc ccctgccctg cagcccaccc agggtgccat gccggccttc 900 gcctctgctt tccagcgccg ggcaggaggg gtcctggttg ctagccatct gcagagcttc 960 ctggaggtgt cgtaccgcgt tctacgccac cttgcgcagc c 1001 <210> 305 <211> 1056 <212> DNA <213> Homo sapiens <400> 305 gctgatgaag aactgtgtgg tggtctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggctccccg ggtggtggtt ctggcggcgg ctccaacatg 540 gctactcaag gtgctatgcc agcttttgct tctgcttttc aacgtcgtgc aggtggtgtt 600 ctggttgcta gccatctgca gagcttcctg gaggtgtcgt accgcgttct acgccacctt 660 gcgcagccct ctggcggctc tggcggctct cagagcttcc tgctcaagtc tttagagcaa 720 gtgagaaaga tccagggcga tggcgcagcg ctccaggaga agctgtgtgc cacctacaag 780 ctgtgccacc ccgaggagct ggtgctgctc ggacactctc tgggcatccc ctgggctccc 840 ctgagctcct gccccagcca ggccctgcag ctggcaggct gcttgagcca actccatagc 900 ggccttttcc tctaccaggg gctcctgcag gccctggaag ggatatcccc cgagttgggt 960 cccaccttgg acacactgca gctggacgtc gccgactttg ccaccaccat ctggcagcag 1020 atggaagaac tgggaatggc ccctgccctg cagccc 1056 <210> 306 <211> 1101 <212> DNA <213> Homo sapiens <400> 306 gctactcaag gtgctatgcc agcttttgct tctgcttttc aacgtcgtgc aggtggtgtt 60 ctggttgcta gccatctgca gagcttcctg gaggtgtcgt accgcgttct acgccacctt 120 gcgcagccct ctggcggctc tggcggctct cagagcttcc tgctcaagtc tttagagcaa 180 gtgagaaaga tccagggcga tggcgcagcg ctccaggaga agctgtgtgc cacctacaag 240 ctgtgccacc ccgaggagct ggtgctgctc ggacactctc tgggcatccc ctgggctccc 300 ctgagctcct gccccagcca ggccctgcag ctggcaggct gcttgagcca actccatagc 360 ggccttttcc tctaccaggg gctcctgcag gccctggaag ggatatcccc cgagttgggt 420 cccaccttgg acacactgca gctggacgtc gccgactttg ccaccaccat ctggcagcag 480 atggaagaac tgggaatggc ccctgccctg cagccctacg tagagggcgg tggaggctcc 540 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 600 cataaatctc caaacatggc cgacgaggag ctctgcgggg gcctctggcg gctggtcctg 660 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 720 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 780 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 840 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 900 cagcccgact cctcaaccct gggcggtggg tcaggaggtg ggtcaggagg tggatccgga 960 ggtggctcag ggggaggtag tggtacccag gactgctcct tccaacacag ccccatctcc 1020 tccgacttcg ctgtcaaaat ccgtgagctg tctgactacc tgcttcaaga ttacccagtc 1080 accgtggcct ccaacctgca g 1101 <210> 307 <211> 1032 <212> DNA <213> Homo sapiens <400> 307 gccgacgagg agctgtgcgg tggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggaac ccaggactgc 360 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 420 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgcagtacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggcc gacgaggagc tctgcggggg cctctggcgg 600 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctgggtc caagatgcaa 660 ggcttgctgg agcgcgtgaa cacggagata cactttgtca ccaaatgtgc ctttcagccc 720 ccccccagct gtcttcgctt cgtccagacc aacatctccc gcctcctgca ggagacctcc 780 gagcagctgg tggcgctgaa gccctggatc actcgccaga acttctcccg gtgcctggag 840 ctgcagtgtc agcccgactc ctcaaccctg ggcggtgggt caggaggtgg gtcaggaggt 900 ggatccggag gtggcaccca ggactgctcc ttccaacaca gccccatctc ctccgacttc 960 gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag attacccagt caccgtggcc 1020 tccaacctgc ag 1032 <210> 308 <211> 1005 <212> DNA <213> Homo sapiens <400> 308 gctgatgaag aactgtgtgg tggtctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 540 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac ccaggactgc 600 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 660 tacctgcttc aaaattaccc agtcaccgtg gcctccaacc tgcaggacga ggagctctgc 720 gggggcctct ggcggctggt cctggcacag cgctggatgg agcggctcaa gactgtcgct 780 gggtccaaga tgcaaggctt gctggagcgc gtgaacacgg agatacactt tgtcaccaaa 840 tgtgcctttc agcccccccc cagctgtctt cgcttcgtcc agaccaacat ctcccgcctc 900 ctgcaggaga cctccgagca gctggtggcg ctgaagccct ggatcactcg ccagaacttc 960 tcccggtgcc tggagctgca gtgtcagccc gactcctcaa ccctg 1005 <210> 309 <211> 1650 <212> DNA <213> Homo sapiens <400> 309 gctgatgaag aactgtgtgg tggtctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggctccccg ggtggtggtt ctggcggcgg ctccaacatg 540 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 600 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 660 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 720 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 780 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 840 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 900 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 960 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 1020 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 1080 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 1140 aaagaatctc ataaatctcc aaacatggct gatgaagaac tgtgtggtgg tctgtggcgg 1200 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctgggtc caagatgcaa 1260 ggcttgctgg agcgcgtgaa cacggagata cactttgtca ccaaatgtgc ctttcagccc 1320 ccccccagct gtcttcgctt cgtccagacc aacatctccc gcctcctgca ggagacctcc 1380 gagcagctgg tggcgctgaa gccctggatc actcgccaga acttctcccg gtgcctggag 1440 ctgcagtgtc agcccgactc ctcaaccctg ggcggtgggt caggaggtgg gtcaggaggt 1500 ggatccggag gtggctcagg gggaggtagt ggtacccagg actgctcctt ccaacacagc 1560 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 1620 tacccagtca ccgtggcctc caacctgcag 1650 <210> 310 <211> 1632 <212> DNA <213> Homo sapiens <400> 310 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggct gatgaagaac tgtgtggtgg tctgtggcgg 660 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctgggtc caagatgcaa 720 ggcttgctgg agcgcgtgaa cacggagata cactttgtca ccaaatgtgc ctttcagccc 780 ccccccagct gtcttcgctt cgtccagacc aacatctccc gcctcctgca ggagacctcc 840 gagcagctgg tggcgctgaa gccctggatc actcgccaga acttctcccg gtgcctggag 900 ctgcagtgtc agcccgactc ctcaaccctg ggcggtgggt caggaggtgg gtcaggaggt 960 ggatccggag gtggctcagg gggaggtagt ggtacccagg actgctcctt ccaacacagc 1020 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 1080 tacccagtca ccgtggcctc caacctgcag tacgtagagg gcggtggagg ctccccgggt 1140 gaaccgtctg gtccaatctc tactatcaac ccgtctcctc cgtctaaaga atctcataaa 1200 tctccaaaca tggctaccca ggactgctcc ttccaacaca gccccatctc ctccgacttc 1260 gctgtcaaaa tccgtgagct gtctgactac ctgcttcaag attacccagt caccgtggcc 1320 tccaacctgc aggacgagga gctctgcggg ggcctctggc ggctggtcct ggcacagcgc 1380 tggatggagc ggctcaagac tgtcgctggg tccaagatgc aaggcttgct ggagcgcgtg 1440 aacacggaga tacactttgt caccaaatgt gcctttcagc ccccccccag ctgtcttcgc 1500 ttcgtccaga ccaacatctc ccgcctcctg caggagacct ccgagcagct ggtggcgctg 1560 aagccctgga tcactcgcca gaacttctcc cggtgcctgg agctgcagtg tcagcccgac 1620 tcctcaaccc tg 1632 <210> 311 <211> 1695 <212> DNA <213> Homo sapiens <400> 311 gctacaccat tgggccctgc cagctccctg ccccagagct tcctgctcaa gtctttagag 60 caagtgagaa agatccaggg cgatggcgca gcgctccagg agaagctgtg tgccacctac 120 aagctgtgcc accccgagga gctggtgctg ctcggacact ctctgggcat cccctgggct 180 cccctgagct cctgccccag ccaggccctg cagctggcag gctgcttgag ccaactccat 240 agcggccttt tcctctacca ggggctcctg caggccctgg aagggatatc ccccgagttg 300 ggtcccacct tggacacact gcagctggac gtcgccgact ttgccaccac catctggcag 360 cagatggaag aactgggaat ggcccctgcc ctgcagccca cccagggtgc catgccggcc 420 ttcgcctctg ctttccagcg ccgggcagga ggggtcctgg ttgctagcca tctgcagagc 480 ttcctggagg tgtcgtaccg cgttctacgc caccttgcgc agccctacgt agagggcggt 540 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 600 aaagaatctc ataaatctcc aaacatggct gatgaagaac tgtgtggtgg tctgtggcgg 660 ctggtcctgg cacagcgctg gatggagcgg ctcaagactg tcgctgggtc caagatgcaa 720 ggcttgctgg agcgcgtgaa cacggagata cactttgtca ccaaatgtgc ctttcagccc 780 ccccccagct gtcttcgctt cgtccagacc aacatctccc gcctcctgca ggagacctcc 840 gagcagctgg tggcgctgaa gccctggatc actcgccaga acttctcccg gtgcctggag 900 ctgcagtgtc agcccgactc ctcaaccctg ggcggtgggt caggaggtgg gtcaggaggt 960 ggatccggag gtggctcagg gggaggtagt ggtacccagg actgctcctt ccaacacagc 1020 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 1080 tacccagtca ccgtggcctc caacctgcag tacgtagagg gcggtggagg ctccccgggt 1140 gaaccgtctg gtccaatctc tactatcaac ccgtctcctc cgtctaaaga atctcataaa 1200 tctccaaaca tggctgatga agaactgtgt ggtggtctgt ggcggctggt cctggcacag 1260 cgctggatgg agcggctcaa gactgtcgct gggtccaaga tgcaaggctt gctggagcgc 1320 gtgaacacgg agatacactt tgtcaccaaa tgtgcctttc agcccccccc cagctgtctt 1380 cgcttcgtcc agaccaacat ctcccgcctc ctgcaggaga cctccgagca gctggtggcg 1440 ctgaagccct ggatcactcg ccagaacttc tcccggtgcc tggagctgca gtgtcagccc 1500 gactcctcaa ccctgggcgg tgggtcagga ggtgggtcag gaggtggatc cggaggtggc 1560 tcagggggag gtagtggtac ccaggactgc tccttccaac acagccccat ctcctccgac 1620 ttcgctgtca aaatccgtga gctgtctgac tacctgcttc aagattaccc agtcaccgtg 1680 gcctccaacc tgcag 1695 <210> 312 <211> 1506 <212> DNA <213> Homo sapiens <400> 312 gctaactgct ctataatgat cgatgaaatt atacatcact taaagagacc acctgcacct 60 ttgctggacc cgaacaacct caatgacgaa gacgtctcta tcctgatgga ccgaaacctt 120 cgacttccaa acctggagag cttcgtaagg gctgtcaaga acttagaaaa tgcatcaggt 180 attgaggcaa ttcttcgtaa tctccaacca tgtctgccct ctgccacggc cgcaccctct 240 cgacatccaa tcatcatcaa ggcaggtgac tggcaagaat tccgggaaaa actgacgttc 300 tatctggtta cccttgagca agcgcaggaa caacagtacg tagagggcgg tggaggctcc 360 ccgggtgaac cgtctggtcc aatctctact atcaacccgt ctcctccgtc taaagaatct 420 cataaatctc caaacatggc tgatgaagaa ctgtgtggtg gtctgtggcg gctggtcctg 480 gcacagcgct ggatggagcg gctcaagact gtcgctgggt ccaagatgca aggcttgctg 540 gagcgcgtga acacggagat acactttgtc accaaatgtg cctttcagcc cccccccagc 600 tgtcttcgct tcgtccagac caacatctcc cgcctcctgc aggagacctc cgagcagctg 660 gtggcgctga agccctggat cactcgccag aacttctccc ggtgcctgga gctgcagtgt 720 cagcccgact cctcaaccct gggcggtggg tcaggaggtg ggtcaggagg tggatccgga 780 ggtggctcag ggggaggtag tggtacccag gactgctcct tccaacacag ccccatctcc 840 tccgacttcg ctgtcaaaat ccgtgagctg tctgactacc tgcttcaaga ttacccagtc 900 accgtggcct ccaacctgca gtacgtagag ggcggtggag gctccccggg tgaaccgtct 960 ggtccaatct ctactatcaa cccgtctcct ccgtctaaag aatctcataa atctccaaac 1020 atggctgatg aagaactgtg tggtggtctg tggcggctgg tcctggcaca gcgctggatg 1080 gagcggctca agactgtcgc tgggtccaag atgcaaggct tgctggagcg cgtgaacacg 1140 gagatacact ttgtcaccaa atgtgccttt cagccccccc ccagctgtct tcgcttcgtc 1200 cagaccaaca tctcccgcct cctgcaggag acctccgagc agctggtggc gctgaagccc 1260 tggatcactc gccagaactt ctcccggtgc ctggagctgc agtgtcagcc cgactcctca 1320 accctgggcg gtgggtcagg aggtgggtca ggaggtggat ccggaggtgg ctcaggggga 1380 ggtagtggta cccaggactg ctccttccaa cacagcccca tctcctccga cttcgctgtc 1440 aaaatccgtg agctgtctga ctacctgctt caagattacc cagtcaccgt ggcctccaac 1500 ctgcag 1506 <210> 313 <211> 1674 <212> DNA <213> Homo sapiens <400> 313 gctgatgaag aactgtgtgg tggtctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 cagtacgtag agggcggtgg aggctccccg ggtggtggtt ctggcggcgg ctccaacatg 540 gctgatgaag aactgtgtgg tggtctgtgg cggctggtcc tggcacagcg ctggatggag 600 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 660 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 720 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 780 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 840 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 900 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 960 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 1020 cagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 1080 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggctac accattaggc 1140 cctgccagct ccctgcccca gagcttcctg ctcaagtgct tagagcaagt gaggaagatc 1200 cagggcgatg gcgcagcgct ccaggagaag ctgtgtgcca cctacaagct gtgccacccc 1260 gaggagctgg tgctgctcgg acactctctg ggcatcccct gggctcccct gagctcctgc 1320 cccagccagg ccctgcagct ggcaggctgc ttgagccaac tccatagcgg ccttttcctc 1380 taccaggggc tcctgcaggc cctggaaggg atatcccccg agttgggtcc caccttggac 1440 acactgcagc tggacgtcgc cgactttgcc accaccatct ggcagcagat ggaagaactg 1500 ggaatggccc ctgccctgca gcccacccag ggtgccatgc cggccttcgc ctctgctttc 1560 cagcgccggg caggaggggt cctggttgct agccatctgc agagcttcct ggaggtgtcg 1620 taccgcgttc tacgccacct tgcgcagccc tgataaggat ccgaattcgg cagc 1674 <210> 314 <211> 1470 <212> DNA <213> Homo sapiens <400> 314 gccgacgagg agctgtgcgg tggcctctgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggaac ccaggactgc 360 tccttccaac acagccccat ctcctccgac ttcgctgtca aaatccgtga gctgtctgac 420 tacctgcttc aagattaccc agtcaccgtg gcctccaacc tgcagtacgt agagggcggt 480 ggaggctccc cgggtgaacc gtctggtcca atctctacta tcaacccgtc tcctccgtct 540 aaagaatctc ataaatctcc aaacatggct aactgctcta taatgatcga tgaaattata 600 catcacttaa agagaccacc taaccctttg ctggacccga acaacctcaa ttctgaagac 660 atggatatcc tgatggaacg aaaccttcga actccaaacc tgctcgcatt cgtaagggct 720 gtcaagcact tagaaaatgc atcaggtatt gaggcaattc ttcgtaatct ccaaccatgt 780 ctgccctctg ccacggccgc accctctcga catccaatca tcatcaaggc aggtgactgg 840 caagaattcc gggaaaaact gacgttctat ctggttaccc ttgagcaagc gcaggaacaa 900 cagtacgtag agggcggtgg aggctccccg ggtgaaccgt ctggtccaat ctctactatc 960 aacccgtctc ctccgtctaa agaatctcat aaatctccaa acatggccga cgaggagctc 1020 tgcgggggcc tctggcggct ggtcctggca cagcgctgga tggagcggct caagactgtc 1080 gctgggtcca agatgcaagg cttgctggag cgcgtgaaca cggagataca ctttgtcacc 1140 aaatgtgcct ttcagccccc ccccagctgt cttcgcttcg tccagaccaa catctcccgc 1200 ctcctgcagg agacctccga gcagctggtg gcgctgaagc cctggatcac tcgccagaac 1260 ttctcccggt gcctggagct gcagtgtcag cccgactcct caaccctggg cggtgggtca 1320 ggaggtgggt caggaggtgg atccggaggt ggcacccagg actgctcctt ccaacacagc 1380 cccatctcct ccgacttcgc tgtcaaaatc cgtgagctgt ctgactacct gcttcaagat 1440 tacccagtca ccgtggcctc caacctgcag 1470 <210> 315 <211> 1194 <212> DNA <213> Homo sapiens <400> 315 gctgatgaag aactgtgtgg tggtctgtgg cggctggtcc tggcacagcg ctggatggag 60 cggctcaaga ctgtcgctgg gtccaagatg caaggcttgc tggagcgcgt gaacacggag 120 atacactttg tcaccaaatg tgcctttcag ccccccccca gctgtcttcg cttcgtccag 180 accaacatct cccgcctcct gcaggagacc tccgagcagc tggtggcgct gaagccctgg 240 atcactcgcc agaacttctc ccggtgcctg gagctgcagt gtcagcccga ctcctcaacc 300 ctgggcggtg ggtcaggagg tgggtcagga ggtggatccg gaggtggctc agggggaggt 360 agtggtaccc aggactgctc cttccaacac agccccatct cctccgactt cgctgtcaaa 420 atccgtgagc tgtctgacta cctgcttcaa gattacccag tcaccgtggc ctccaacctg 480 caggaattca agcttgagcc cagagggccc acaatcaagc cctgtcctcc atgcaaatgc 540 ccagcaccta acctcttggg tggaccatcc gtcttcatct tccctccaaa gatcaaggat 600 gtactcatga tctccctgag ccccatagtc acatgtgtgg tggtggatgt gagcgaggat 660 gacccagatg tccagatcag ctggtttgtg aacaacgtgg aagtacacac agctcagaca 720 caaacccata gagaggatta caacagtact ctccgggcgg tcagtgccct ccccatccag 780 caccaggact ggatgagtgg caaggagttc aaatgcaagg tcaacaacaa agacctccca 840 gcgcccatcg agagaaccat ctcaaaaccc aaagggtcag taagagctcc acaggtatat 900 gtcttgcctc caccagaaga agagatgact aagaaacagg tcactctgac ctgcatggtc 960 acagacttca tgcctgaaga catttacgtg gagtggacca acaacgggaa aacagagcta 1020 aactacaaga acactgaacc agtcctggac tctgatggtt cttacttcat gtacagcaag 1080 ctgagagtgg aaaagaagaa ctgggtggaa agaaatagct actcctgttc agtggtccac 1140 gagggtctgc acaatcacca cacgactaag agcttctccc ggactccggg taaa 1194 <210> 316 <211> 1131 <212> DNA <213> Homo sapiens <400> 316 gccacccagg actgctcctt tcaacacagc cccatctcct ccgacttcgc tgtcaaaatc 60 cgtgagctgt ctgactacct gcttcaagat tacccagtca ccgtggcctc caacctgcag 120 gacgaggagc tctgcggggg cctctggcgg ctggtcctgg cacagcgctg gatggagcgg 180 ctcaagactg tcgctgggtc caagatgcaa ggcttgctgg agcgcgtgaa cacggagata 240 cactttgtca ccaaatgtgc ctttcagccc ccccccagct gtcttcgctt cgtccagacc 300 aacatctccc gcctcctgca ggagacctcc gagcagctgg tggcgctgaa gccctggatc 360 actcgccaga acttctcccg gtgcctggag ctgcagtgtc agcccgactc ctcaaccctg 420 gaattcaagc ttgagcccag agggcccaca atcaagccct gtcctccatg caaatgccca 480 gcacctaacc tcttgggtgg accatccgtc ttcatcttcc ctccaaagat caaggatgta 540 ctcatgatct ccctgagccc catagtcaca tgtgtggtgg tggatgtgag cgaggatgac 600 ccagatgtcc agatcagctg gtttgtgaac aacgtggaag tacacacagc tcagacacaa 660 acccatagag aggattacaa cagtactctc cgggcggtca gtgccctccc catccagcac 720 caggactgga tgagtggcaa ggagttcaaa tgcaaggtca acaacaaaga cctcccagcg 780 cccatcgaga gaaccatctc aaaacccaaa gggtcagtaa gagctccaca ggtatatgtc 840 ttgcctccac cagaagaaga gatgactaag aaacaggtca ctctgacctg catggtcaca 900 gacttcatgc ctgaagacat ttacgtggag tggaccaaca acgggaaaac agagctaaac 960 tacaagaaca ctgaaccagt cctggactct gatggttctt acttcatgta cagcaagctg 1020 agagtggaaa agaagaactg ggtggaaaga aatagctact cctgttcagt ggtccacgag 1080 ggtctgcaca atcaccacac gactaagagc ttctcccgga ctccgggtaa a 1131 <210> 317 <211> 45 <212> DNA <213> Homo sapiens <400> 317 acgtccatgg cntcnccngc nccncctgct tgtgcactcc gagtc 45 <210> 318 <211> 30 <212> DNA <213> Homo sapiens <400> 318 atgcacgaat tccctgacgc agagggtgga 30 <210> 319 <211> 33 <212> DNA <213> Homo sapiens <400> 319 tgacaagctt acctgacgca gagggtggac cct 33 <210> 320 <211> 10 <212> DNA <213> Homo sapiens <400> 320 aattcggcaa 10 <210> 321 <211> 10 <212> DNA <213> Homo sapiens <400> 321 catgttgccg 10 <210> 322 <211> 13 <212> DNA <213> Homo sapiens <400> 322 aattcggcgg caa 13 <210> 323 <211> 13 <212> DNA <213> Homo sapiens <400> 323 catgttgccg ccg 13 <210> 324 <211> 22 <212> DNA <213> Homo sapiens <400> 324 aattcggcgg caacggcggc aa 22 <210> 325 <211> 22 <212> DNA <213> Homo sapiens <400> 325 catgttgccg ccgttgccgc cg 22 <210> 326 <211> 27 <212> DNA <213> Homo sapiens <400> 326 cgatccatgg aggttcaccc tttgcct 27 <210> 327 <211> 29 <212> DNA <213> Homo sapiens <400> 327 gatcaagctt atgggcactg gctcagtct 29 <210> 328 <211> 27 <212> DNA <213> Homo sapiens <400> 328 cgatacatgt tgcctacacc tgtcctg 27 <210> 329 <211> 29 <212> DNA <213> Homo sapiens <400> 329 gatcaagctt aagggtgaac ctctgggca 29 <210> 330 <211> 27 <212> DNA <213> Homo sapiens <400> 330 cgatccatgg tcctgctgcc tgctgtg 27 <210> 331 <211> 29 <212> DNA <213> Homo sapiens <400> 331 gatcaagctt aaggtgtagg caaagggtg 29 <210> 332 <211> 30 <212> DNA <213> Homo sapiens <400> 332 cgatccatgg ctgtggactt tagcttggga 30 <210> 333 <211> 29 <212> DNA <213> Homo sapiens <400> 333 gatcaagctt aaggcagcag gacaggtgt 29 <210> 334 <211> 27 <212> DNA <213> Homo sapiens <400> 334 cgatccatgg actttagctt gggagaa 27 <210> 335 <211> 29 <212> DNA <213> Homo sapiens <400> 335 gatcaagctt acacagcagg cagcaggac 29 <210> 336 <211> 27 <212> DNA <213> Homo sapiens <400> 336 cgatccatgg gagaatggaa aacccag 27 <210> 337 <211> 29 <212> DNA <213> Homo sapiens <400> 337 gatcaagctt acaagctaaa gtccacagc 29 <210> 338 <211> 27 <212> DNA <213> Homo sapiens <400> 338 cgatccatgg gacccacttg cctctca 27 <210> 339 <211> 29 <212> DNA <213> Homo sapiens <400> 339 gatcaagctt acagttgtcc ccgtgctgc 29 <210> 340 <211> 27 <212> DNA <213> Homo sapiens <400> 340 cagtccatgg gaacccagct tcctcca 27 <210> 341 <211> 29 <212> DNA <213> Homo sapiens <400> 341 gatcaagctt aaaggaggct ctgcagggc 29 <210> 342 <211> 27 <212> DNA <213> Homo sapiens <400> 342 cgatccatgg gcaggaccac agctcac 27 <210> 343 <211> 30 <212> DNA <213> Homo sapiens <400> 343 gatcaagctt actgtggagg aagctgggtt 30 <210> 344 <211> 30 <212> DNA <213> Homo sapiens <400> 344 cgatccatgg ctcacaagga tcccaatgcc 30 <210> 345 <211> 29 <212> DNA <213> Homo sapiens <400> 345 gatcaagctt atgtggtcct gccctgtgg 29 <210> 346 <211> 30 <212> DNA <213> Homo sapiens <400> 346 cgatccatgg atcccaatgc catcttcctg 30 <210> 347 <211> 29 <212> DNA <213> Homo sapiens <400> 347 gatcaagctt acttgtgagc tgtggtcct 29 <210> 348 <211> 30 <212> DNA <213> Homo sapiens <400> 348 cgatccatgg ccatcttcct gagcttccaa 30 <210> 349 <211> 32 <212> DNA <213> Homo sapiens <400> 349 gatcaagctt aattgggatc cttgtgagct gt 32 <210> 350 <211> 83 <212> DNA <213> Homo sapiens <400> 350 aattccgtcg taaactgacc ttctatctga aaaccttgga gaacgcgcag gctcaacagt 60 acgtagaggg cggtggaggc tcc 83 <210> 351 <211> 83 <212> DNA <213> Homo sapiens <400> 351 ccggggagcc tccaccgccc tctacgtact gttgagcctg cgcgttctcc aaggttttca 60 gatagaaggt cagtttacga cgg 83 <210> 352 <211> 59 <212> DNA <213> Homo sapiens <400> 352 gttacccttg agcaagcgca ggaacaacag ggtggtggct ctaactgctc tataatgat 59 <210> 353 <211> 56 <212> DNA <213> Homo sapiens <400> 353 cgatcattat agagcagtta gagccaccac cctgttgttc ctgcgcttgc tcaagg 56 <210> 354 <211> 83 <212> DNA <213> Homo sapiens <400> 354 gttacccttg agcaagcgca ggaacaacag ggtggtggct ctggcggtgg cagcggcggc 60 ggttctaact gctctataat gat 83 <210> 355 <211> 80 <212> DNA <213> Homo sapiens <400> 355 cgatcattat agagcagtta gaaccgccgc cgctgccacc gccagagcca ccaccctgtt 60 gttcctgcgc ttgctcaagg 80 <210> 356 <211> 32 <212> DNA <213> Homo sapiens <400> 356 gatcgaccat ggctctggac ccgaacaacc tc 32 <210> 357 <211> 28 <212> DNA <213> Homo sapiens <400> 357 ctcgattacg tacaaaggtg caggtggt 28 <210> 358 <211> 32 <212> DNA <213> Homo sapiens <400> 358 gatcgaccat ggctaatgca tcaggtattg ag 32 <210> 359 <211> 28 <212> DNA <213> Homo sapiens <400> 359 ctcgattacg tattctaagt tcttgaca 28 <210> 360 <211> 32 <212> DNA <213> Homo sapiens <400> 360 gatcgaccat ggctgcaccc tctcgacatc ca 32 <210> 361 <211> 28 <212> DNA <213> Homo sapiens <400> 361 ctcgattacg taggccgtgg cagagggc 28 <210> 362 <211> 32 <212> DNA <213> Homo sapiens <400> 362 gatcgaccat ggctgcaggt gactggcaag aa 32 <210> 363 <211> 28 <212> DNA <213> Homo sapiens <400> 363 ctcgattacg tacttgatga tgattgga 28 <210> 364 <211> 54 <212> DNA <213> Homo sapiens <400> 364 gctctgagag ccgccagagc cgccagaggg ctgcgcaagg tggcgtagaa cgcg 54 <210> 365 <211> 54 <212> DNA <213> Homo sapiens <400> 365 cagccctctg gcggctctgg cggctctcag agcttcctgc tcaagtcttt agag 54 <210> 366 <211> 18 <212> DNA <213> Homo sapiens <400> 366 gggctgcgca aggtggcg 18 <210> 367 <211> 21 <212> DNA <213> Homo sapiens <400> 367 acaccattgg gccctgccag c 21 <210> 368 <211> 32 <212> DNA <213> Homo sapiens <400> 368 gatcgaccat ggcttacaag ctgtgccacc cc 32 <210> 369 <211> 36 <212> DNA <213> Homo sapiens <400> 369 cgatcgaagc ttattaggtg gcacacagct tctcct 36 <210> 370 <211> 32 <212> DNA <213> Homo sapiens <400> 370 gatcgaccat ggctcccgag ttgggtccca cc 32 <210> 371 <211> 36 <212> DNA <213> Homo sapiens <400> 371 cgatcgaagc ttattaggat atcccttcca gggcct 36 <210> 372 <211> 32 <212> DNA <213> Homo sapiens <400> 372 gatcgaccat ggctatggcc cctgccctgc ag 32 <210> 373 <211> 36 <212> DNA <213> Homo sapiens <400> 373 cgatcgaagc ttattatccc agttcttcca tctgct 36 <210> 374 <211> 32 <212> DNA <213> Homo sapiens <400> 374 gatcgaccat ggctacccag ggtgccatgc cg 32 <210> 375 <211> 36 <212> DNA <213> Homo sapiens <400> 375 cgatcgaagc ttattagggc tgcagggcag gggcca 36 <210> 376 <211> 32 <212> DNA <213> Homo sapiens <400> 376 gatcgaccat ggcttctgct ttccagcgcc gg 32 <210> 377 <211> 36 <212> DNA <213> Homo sapiens <400> 377 cgatcgaagc ttattaggcg aaggccggca tggcac 36 <210> 378 <211> 21 <212> DNA <213> Homo sapiens <400> 378 gtagagggcg gtggaggctc c 21 <210> 379 <211> 25 <212> DNA <213> Homo sapiens <400> 379 ccggggagcc tccaccgccc tctac 25 <210> 380 <211> 53 <212> DNA <213> Homo sapiens <400> 380 ttctacgcca ccttgcgcag cccggcggcg gctctgacat gtctacacca ttg 53 <210> 381 <211> 53 <212> DNA <213> Homo sapiens <400> 381 caatggtgta gacatgtcag agccgccgcc gggctgcgca aggtggcgta gaa 53 <210> 382 <211> 37 <212> DNA <213> Homo sapiens <400> 382 gtcagaccat ggccgattac ccagtcaccg tggcctc 37 <210> 383 <211> 37 <212> DNA <213> Homo sapiens <400> 383 gtcagcccat ggccgcctcc aacctgcagg acgagga 37 <210> 384 <211> 38 <212> DNA <213> Homo sapiens <400> 384 gtcagaccat ggccgtcgct gggtccaaga tgcaaggc 38 <210> 385 <211> 38 <212> DNA <213> Homo sapiens <400> 385 gtcagaccat ggcccgcttc gtccagacca acatctcc 38 <210> 386 <211> 38 <212> DNA <213> Homo sapiens <400> 386 gtcagaccat ggccaccaac atctcccgcc tcctgcag 38 <210> 387 <211> 39 <212> DNA <213> Homo sapiens <400> 387 tctgacaagc ttattgaagc aggtagtcag acagctcac 39 <210> 388 <211> 38 <212> DNA <213> Homo sapiens <400> 388 tctgacaagc ttacacggtg actgggtaat cttgaagc 38 <210> 389 <211> 37 <212> DNA <213> Homo sapiens <400> 389 tctgacaagc ttaagtcttg agccgctcca tccagcg 37 <210> 390 <211> 32 <212> DNA <213> Homo sapiens <400> 390 gtcaagaagc ttacggctga aaggcacatt tg 32 <210> 391 <211> 36 <212> DNA <213> Homo sapiens <400> 391 tctgacaagc ttaaagacag ctgggggggg gctgaa 36 <210> 392 <211> 37 <212> DNA <213> Homo sapiens <400> 392 ctcgacaagc ttactggacg aagcgaagac agctggg 37 <210> 393 <211> 57 <212> DNA <213> Homo sapiens <400> 393 gttgccatgg cntcnaayct gcargaygar garctgtgcg ggggcctctg gcggctg 57 <210> 394 <211> 57 <212> DNA <213> Homo sapiens <400> 394 gttgccatgg cnaayctgca rgaygargar ctgtgygggg gcctctggcg gctggtc 57 <210> 395 <211> 57 <212> DNA <213> Homo sapiens <400> 395 gttgccatgg cnctgcarga ygargarctg tgyggyggcc tctggcggct ggtcctg 57 <210> 396 <211> 57 <212> DNA <213> Homo sapiens <400> 396 gttgccatgg cncargayga rgarctgtgy ggyggyctct ggcggctggt cctggca 57 <210> 397 <211> 57 <212> DNA <213> Homo sapiens <400> 397 gttgccatgg cngaygarga rctgtgyggy ggyctctggc ggctggtcct ggcacag 57 <210> 398 <211> 57 <212> DNA <213> Homo sapiens <400> 398 gttgccatgg cngargarct gtgyggyggy ctctggcggc tggtcctggc acagcgc 57 <210> 399 <211> 57 <212> DNA <213> Homo sapiens <400> 399 gttgccatgg cngarctgtg yggyggyctg tggcgyctgg tcctggcaca gcgctgg 57 <210> 400 <211> 57 <212> DNA <213> Homo sapiens <400> 400 gttgccatgg cnctgtgygg yggyctgtgg cgyctggtcc tggcacagcg ctggatg 57 <210> 401 <211> 42 <212> DNA <213> Homo sapiens <400> 401 gttgccatgg cwgatgaaga actgtgtggn ggnctgtggc gg 42 <210> 402 <211> 30 <212> DNA <213> Homo sapiens <400> 402 tatgcaagct taggccacgg tgactgggta 30 <210> 403 <211> 30 <212> DNA <213> Homo sapiens <400> 403 tatgcaagct taggaggcca cggtgactgg 30 <210> 404 <211> 30 <212> DNA <213> Homo sapiens <400> 404 tatgcaagct tagttggagg ccacggtgac 30 <210> 405 <211> 30 <212> DNA <213> Homo sapiens <400> 405 tatgcaagct tacaggttgg aggccacggt 30 <210> 406 <211> 30 <212> DNA <213> Homo sapiens <400> 406 tatgcaagct tagtccaggt tggaggccac 30 <210> 407 <211> 30 <212> DNA <213> Homo sapiens <400> 407 tatgcaagct tactcgtcca ggttggaggc 30 <210> 408 <211> 30 <212> DNA <213> Homo sapiens <400> 408 tatgcaagct tactcctcgt ccaggttgga 30 <210> 409 <211> 44 <212> DNA <213> Homo sapiens <400> 409 gactagccat ggcngaygar garctgtgyg gtggcctctg gcgg 44 <210> 410 <211> 32 <212> DNA <213> Homo sapiens <400> 410 gactagtacg tactgcaggt tggaggccac gg 32 <210> 411 <211> 36 <212> DNA <213> Homo sapiens <400> 411 gcaggttacg tattgaagca ggtagtcaga cagctc 36 <210> 412 <211> 36 <212> DNA <213> Homo sapiens <400> 412 gcaggttacg tacacggtga ctgggtaatc ttgaag 36 <210> 413 <211> 35 <212> DNA <213> Homo sapiens <400> 413 gcaggttacg taagtcttga gccgctccat ccagc 35 <210> 414 <211> 36 <212> DNA <213> Homo sapiens <400> 414 gcaggttacg tagccagcga cagtcttgag ccgctc 36 <210> 415 <211> 49 <212> DNA <213> Homo sapiens <400> 415 gtcaagccat ggcnccrccr agctgtctrc gcttcgttca gaccaactc 49 <210> 416 <211> 38 <212> DNA <213> Homo sapiens <400> 416 gcaggttacg tacggctgaa aggcacattt ggtgacaa 38 <210> 417 <211> 30 <212> DNA <213> Homo sapiens <400> 417 gcaggttacg taaagacagc tggggggggg 30 <210> 418 <211> 34 <212> DNA <213> Homo sapiens <400> 418 gcaggttacg tactggacga agcgaagaca gctg 34 <210> 419 <211> 29 <212> DNA <213> Homo sapiens <400> 419 tatgctacgt aggccacggt gactgggta 29 <210> 420 <211> 29 <212> DNA <213> Homo sapiens <400> 420 tatgctacgt aggaggccac ggtgactgg 29 <210> 421 <211> 29 <212> DNA <213> Homo sapiens <400> 421 tatgctacgt agttggaggc cacggtgac 29 <210> 422 <211> 29 <212> DNA <213> Homo sapiens <400> 422 tatgctacgt acaggttgga ggccacggt 29 <210> 423 <211> 29 <212> DNA <213> Homo sapiens <400> 423 tatgctacgt agtccaggtt ggaggccac 29 <210> 424 <211> 29 <212> DNA <213> Homo sapiens <400> 424 tatgctacgt actcgtccag gttggaggc 29 <210> 425 <211> 29 <212> DNA <213> Homo sapiens <400> 425 tatgctacgt actcctcgtc caggttgga 29 <210> 426 <211> 46 <212> DNA <213> Homo sapiens <400> 426 tcagttggat ccggcggcgg aagcggaggt ggctctgggg gaggta 46 <210> 427 <211> 48 <212> DNA <213> Homo sapiens <400> 427 tcagttggat cctccgccag aaccaccgcc tgacccacct cctgaccc 48 <210> 428 <211> 60 <212> DNA <213> Homo sapiens <400> 428 gtctgaggcg ccaccgcacc gaccgctgga caaccgcctc tgacccagga ctgctccttc 60 60 <210> 429 <211> 46 <212> DNA <213> Homo sapiens <400> 429 gtctgaggcg ccaccgcacc gaccacccag gactgctcct tccaac 46 <210> 430 <211> 60 <212> DNA <213> Homo sapiens <400> 430 gtctgaggcg ccgagtggac gcgggctcca cggtggcggc agggttgagg agtcgggctg 60 60 <210> 431 <211> 57 <212> DNA <213> Homo sapiens <400> 431 gttgccatgg cntcnaayct gcargaygar garctgtgcg ggggcctctg gcggctg 57 <210> 432 <211> 57 <212> DNA <213> Homo sapiens <400> 432 gttgccatgg cnaayctgca rgaygargar ctgtgygggg gcctctggcg gctggtc 57 <210> 433 <211> 57 <212> DNA <213> Homo sapiens <400> 433 gttgccatgg cnctgcarga ygargarctg tgyggyggcc tctggcggct ggtcctg 57 <210> 434 <211> 57 <212> DNA <213> Homo sapiens <400> 434 gttgccatgg cncargayga rgarctgtgy ggyggyctct ggcggctggt cctggca 57 <210> 435 <211> 57 <212> DNA <213> Homo sapiens <400> 435 gttgccatgg cngaygarga rctgtgyggy ggyctctggc ggctggtcct ggcacag 57 <210> 436 <211> 57 <212> DNA <213> Homo sapiens <400> 436 gttgccatgg cngargarct gtgyggyggy ctctggcggc tggtcctggc acagcgc 57 <210> 437 <211> 57 <212> DNA <213> Homo sapiens <400> 437 gttgccatgg cngarctgtg yggyggyctg tggcgyctgg tcctggcaca gcgctgg 57 <210> 438 <211> 57 <212> DNA <213> Homo sapiens <400> 438 gttgccatgg cnctgtgygg yggyctgtgg cgyctggtcc tggcacagcg ctggatg 57 <210> 439 <211> 30 <212> DNA <213> Homo sapiens <400> 439 tatgcaagct taggccacgg tgactgggta 30 <210> 440 <211> 30 <212> DNA <213> Homo sapiens <400> 440 tatgcaagct taggaggcca cggtgactgg 30 <210> 441 <211> 30 <212> DNA <213> Homo sapiens <400> 441 tatgcaagct tagttggagg ccacggtgac 30 <210> 442 <211> 30 <212> DNA <213> Homo sapiens <400> 442 tatgcaagct tacaggttgg aggccacggt 30 <210> 443 <211> 30 <212> DNA <213> Homo sapiens <400> 443 tatgcaagct tactgcaggt tggaggccac 30 <210> 444 <211> 30 <212> DNA <213> Homo sapiens <400> 444 tatgcaagct tagtcctgca ggttggaggc 30 <210> 445 <211> 30 <212> DNA <213> Homo sapiens <400> 445 tatgcaagct tactcgtcct gcaggttgga 30 <210> 446 <211> 30 <212> DNA <213> Homo sapiens <400> 446 tatgcaagct tactcctcgt cctgcaggtt 30 <210> 447 <211> 47 <212> DNA <213> Homo sapiens <400> 447 gctacgtcta gatctcctga cctcgaccca ggactgctcc ttccaac 47 <210> 448 <211> 68 <212> DNA <213> Homo sapiens <400> 448 gctagttcta gaccatcctg gctgacacgg tgaaacaccg tctctacggg ctgacactgc 60 agctccag 68 <210> 449 <211> 56 <212> DNA <213> Homo sapiens <400> 449 gtcagtacta gtatgggtgt ccgggctctt cggctcctgc aggttggagg ccacgg 56 <210> 450 <211> 45 <212> DNA <213> Homo sapiens <400> 450 gtcagtacta gtccgccatc tccgacacca ttaggccctg ccagc 45 <210> 451 <211> 49 <212> DNA <213> Homo sapiens <400> 451 gtcagttccg gagatttcgg ttctgcagag ggctgcgcaa ggtggcgta 49 <210> 452 <211> 64 <212> DNA <213> Homo sapiens <400> 452 gtcagttccg gatactcata ccagcccgcc atccccgggt tctaatctgc aagatgaaga 60 gctg 64 <210> 453 <211> 61 <212> DNA <213> Homo sapiens <400> 453 gtcagtacta gtatgggtgt ccgggctctt cggaaaggca catttggtga caaagtgtat 60 c 61 <210> 454 <211> 48 <212> DNA <213> Homo sapiens <400> 454 gtcagtacta gtccgccatc tccgggtaca ccattaggcc ctgccagc 48 <210> 455 <211> 63 <212> DNA <213> Homo sapiens <400> 455 gtcagttccg gatactcata ccagcccgcc atccccgggt aaggcctttc agcccccccc 60 cag 63 <210> 456 <211> 33 <212> DNA <213> Homo sapiens <400> 456 gtcagaccat ggccactcag gactcctctt ttc 33 <210> 457 <211> 27 <212> DNA <213> Homo sapiens <400> 457 cactttgtca ccaaatctgc ctttcag 27 <210> 458 <211> 27 <212> DNA <213> Homo sapiens <400> 458 ctgaaaggca gatttggtga caaagtg 27 <210> 459 <211> 21 <212> DNA <213> Homo sapiens <400> 459 gccccccccc agctctcttc g 21 <210> 460 <211> 21 <212> DNA <213> Homo sapiens <400> 460 cgaagagagc tggggggggg c 21 <210> 461 <211> 41 <212> DNA <213> Homo sapiens <400> 461 gtcagttacg tacagggttg aaggagtcgg gctgagactg c 41 <210> 462 <211> 30 <212> DNA <213> Homo sapiens <400> 462 gtcagtccat ggctactcaa ggtgctatgc 30 <210> 463 <211> 31 <212> DNA <213> Homo sapiens <400> 463 gtagcatacg tagggctgca gggcaggggc c 31 <210> 464 <211> 166 <212> PRT <213> Homo sapiens <400> 464 Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 1 5 10 15 Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 20 25 30 Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 35 40 45 Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 50 55 60 Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 65 70 75 80 Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 85 90 95 Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 100 105 110 Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 115 120 125 Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 130 135 140 Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 145 150 155 160 Cys Arg Thr Gly Asp Arg 165 <210> 465 <211> 165 <212> PRT <213> Homo sapiens <400> 465 Glu Gly Ile Cys Arg Asn Arg Val Thr Asn Asn Val Lys Asp Val Thr 1 5 10 15 Lys Leu Val Ala Asn Leu Pro Lys Asp Tyr Met Ile Thr Leu Lys Tyr 20 25 30 Val Pro Gly Met Asp Val Leu Pro Ser His Cys Trp Ile Ser Glu Met 35 40 45 Val Val Gln Leu Ser Asp Ser Leu Thr Asp Leu Leu Asp Lys Phe Ser 50 55 60 Asn Ile Ser Glu Gly Leu Ser Asn Tyr Ser Ile Ile Asp Lys Leu Val 65 70 75 80 Asn Ile Val Asp Asp Leu Val Glu Cys Val Lys Glu Asn Ser Ser Lys 85 90 95 Asp Leu Lys Lys Ser Phe Lys Ser Pro Glu Pro Arg Leu Phe Thr Pro 100 105 110 Glu Glu Phe Phe Arg Ile Phe Asn Arg Ser Ile Asp Ala Phe Lys Asp 115 120 125 Phe Val Val Ala Ser Glu Thr Ser Asp Cys Val Val Ser Ser Thr Leu 130 135 140 Ser Pro Glu Lys Asp Ser Arg Val Ser Val Thr Lys Pro Phe Met Leu 145 150 155 160 Pro Pro Val Ala Ala 165 <210> 466 <211> 139 <212> PRT <213> Homo sapiens <400> 466 Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 1 5 10 15 Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 20 25 30 Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 35 40 45 Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 50 55 60 Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 65 70 75 80 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 85 90 95 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 100 105 110 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 115 120 125 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 130 135 <210> 467 <211> 155 <212> PRT <213> Homo sapiens <400> 467 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 1 5 10 15 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 20 25 30 His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 50 55 60 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 65 70 75 80 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 85 90 95 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu 100 105 110 Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 115 120 125 Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140 Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe 145 150 155 <210> 468 <211> 309 <212> PRT <213> Homo sapiens <400> 468 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 1 5 10 15 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 20 25 30 His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 50 55 60 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 65 70 75 80 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 85 90 95 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu 100 105 110 Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 115 120 125 Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140 Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Met Ala 145 150 155 160 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 165 170 175 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 180 185 190 His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 195 200 205 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 210 215 220 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 225 230 235 240 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 245 250 255 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Gly 260 265 270 Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln 275 280 285 His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser 290 295 300 Thr Leu Cys Val Arg 305 <210> 469 <211> 312 <212> PRT <213> Homo sapiens <400> 469 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 1 5 10 15 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 20 25 30 His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 50 55 60 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 65 70 75 80 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 85 90 95 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu 100 105 110 Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 115 120 125 Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140 Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Asn Met Ala Ser 145 150 155 160 Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg 165 170 175 Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val His 180 185 190 Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly 195 200 205 Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu Gly 210 215 220 Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln Leu 225 230 235 240 Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln Val 245 250 255 Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu Pro 260 265 270 Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe Leu 275 280 285 Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val 290 295 300 Gly Gly Ser Thr Leu Cys Val Arg 305 310 <210> 470 <211> 313 <212> PRT <213> Homo sapiens <400> 470 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 1 5 10 15 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 20 25 30 His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 50 55 60 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 65 70 75 80 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 85 90 95 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu 100 105 110 Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 115 120 125 Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140 Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Met Ala 145 150 155 160 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 165 170 175 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 180 185 190 His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 195 200 205 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 210 215 220 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 225 230 235 240 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 245 250 255 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu 260 265 270 Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 275 280 285 Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 290 295 300 Val Gly Gly Ser Thr Leu Cys Val Arg 305 310 <210> 471 <211> 316 <212> PRT <213> Homo sapiens <400> 471 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 1 5 10 15 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 20 25 30 His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 50 55 60 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 65 70 75 80 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 85 90 95 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu 100 105 110 Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 115 120 125 Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140 Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Gly Gly 145 150 155 160 Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser 165 170 175 Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys 180 185 190 Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp 195 200 205 Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln 210 215 220 Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala 225 230 235 240 Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu 245 250 255 Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly 260 265 270 Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn 275 280 285 Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe 290 295 300 Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg 305 310 315 <210> 472 <211> 302 <212> PRT <213> Homo sapiens <400> 472 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125 Asn Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 130 135 140 His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln 145 150 155 160 Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 165 170 175 Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 180 185 190 Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 195 200 205 Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 210 215 220 Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg 225 230 235 240 Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val 245 250 255 Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly Ser Gly 260 265 270 Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile 275 280 285 Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr 290 295 300 <210> 473 <211> 317 <212> PRT <213> Homo sapiens <400> 473 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 115 120 125 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140 Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 145 150 155 160 Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala 165 170 175 Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu 180 185 190 Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly 195 200 205 Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr 210 215 220 Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 225 230 235 240 Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala 245 250 255 Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser 260 265 270 Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly 275 280 285 Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln 290 295 300 Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr 305 310 315 <210> 474 <211> 302 <212> PRT <213> Homo sapiens <400> 474 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125 Asn Met Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp 130 135 140 Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly 145 150 155 160 Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala 165 170 175 Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu 180 185 190 Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln 195 200 205 Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu 210 215 220 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 225 230 235 240 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 245 250 255 Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 260 265 270 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 275 280 285 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 290 295 300 <210> 475 <211> 317 <212> PRT <213> Homo sapiens <400> 475 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 115 120 125 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140 Met Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val 145 150 155 160 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met 165 170 175 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser 180 185 190 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln 195 200 205 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 210 215 220 Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu 225 230 235 240 Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu 245 250 255 Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 260 265 270 His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln 275 280 285 Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 290 295 300 Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 305 310 315 <210> 476 <211> 302 <212> PRT <213> Homo sapiens <400> 476 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125 Asn Met Ala Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro 130 135 140 Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala 145 150 155 160 Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 165 170 175 Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu 180 185 190 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 195 200 205 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 210 215 220 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 225 230 235 240 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 245 250 255 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 260 265 270 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 275 280 285 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly 290 295 300 <210> 477 <211> 317 <212> PRT <213> Homo sapiens <400> 477 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 115 120 125 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140 Met Ala Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala 145 150 155 160 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser 165 170 175 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 180 185 190 Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys 195 200 205 Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 210 215 220 Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 225 230 235 240 Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 245 250 255 Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 260 265 270 Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 275 280 285 Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp 290 295 300 Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly 305 310 315 <210> 478 <211> 302 <212> PRT <213> Homo sapiens <400> 478 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125 Asn Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln 130 135 140 Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu 145 150 155 160 Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly 165 170 175 Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg 180 185 190 Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr 195 200 205 Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu 210 215 220 Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln 225 230 235 240 Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln 245 250 255 Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr 260 265 270 Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp 275 280 285 Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 290 295 300 <210> 479 <211> 317 <212> PRT <213> Homo sapiens <400> 479 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 115 120 125 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140 Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 145 150 155 160 Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 165 170 175 Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly Ser 180 185 190 Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys 195 200 205 Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr 210 215 220 Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly 225 230 235 240 Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu 245 250 255 Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly 260 265 270 Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu 275 280 285 Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln 290 295 300 Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 305 310 315 <210> 480 <211> 302 <212> PRT <213> Homo sapiens <400> 480 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125 Asn Met Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala 130 135 140 Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 145 150 155 160 Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu 165 170 175 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 180 185 190 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 195 200 205 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 210 215 220 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 225 230 235 240 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 245 250 255 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 260 265 270 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 275 280 285 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala 290 295 300 <210> 481 <211> 317 <212> PRT <213> Homo sapiens <400> 481 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 115 120 125 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140 Met Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser 145 150 155 160 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 165 170 175 Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys 180 185 190 Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 195 200 205 Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 210 215 220 Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 225 230 235 240 Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 245 250 255 Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 260 265 270 Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp 275 280 285 Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro 290 295 300 Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala 305 310 315 <210> 482 <211> 305 <212> PRT <213> Homo sapiens <400> 482 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125 Asn Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 130 135 140 His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln 145 150 155 160 Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 165 170 175 Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 180 185 190 Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 195 200 205 Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 210 215 220 Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg 225 230 235 240 Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val 245 250 255 Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr Pro Leu Gly Pro 260 265 270 Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val 275 280 285 Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala 290 295 300 Thr 305 <210> 483 <211> 320 <212> PRT <213> Homo sapiens <400> 483 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 115 120 125 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140 Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 145 150 155 160 Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala 165 170 175 Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu 180 185 190 Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly 195 200 205 Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr 210 215 220 Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 225 230 235 240 Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala 245 250 255 Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser 260 265 270 Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr Pro Leu Gly Pro Ala 275 280 285 Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg 290 295 300 Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr 305 310 315 320 <210> 484 <211> 305 <212> PRT <213> Homo sapiens <400> 484 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125 Asn Met Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp 130 135 140 Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly 145 150 155 160 Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala 165 170 175 Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu 180 185 190 Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln 195 200 205 Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 210 215 220 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 225 230 235 240 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 245 250 255 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 260 265 270 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 275 280 285 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 290 295 300 Ser 305 <210> 485 <211> 320 <212> PRT <213> Homo sapiens <400> 485 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 115 120 125 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140 Met Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val 145 150 155 160 Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met 165 170 175 Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser 180 185 190 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln 195 200 205 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 210 215 220 Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 225 230 235 240 Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 245 250 255 Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 260 265 270 Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 275 280 285 Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 290 295 300 Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 305 310 315 320 <210> 486 <211> 305 <212> PRT <213> Homo sapiens <400> 486 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125 Asn Met Ala Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro 130 135 140 Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala 145 150 155 160 Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 165 170 175 Leu Ala Gln Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 180 185 190 Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 195 200 205 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 210 215 220 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 225 230 235 240 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 245 250 255 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 260 265 270 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 275 280 285 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 290 295 300 Gly 305 <210> 487 <211> 320 <212> PRT <213> Homo sapiens <400> 487 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 115 120 125 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140 Met Ala Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala 145 150 155 160 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser 165 170 175 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 180 185 190 Ala Gln Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe 195 200 205 Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala 210 215 220 Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu 225 230 235 240 Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu 245 250 255 Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln 260 265 270 Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu 275 280 285 Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp 290 295 300 Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly 305 310 315 320 <210> 488 <211> 305 <212> PRT <213> Homo sapiens <400> 488 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125 Asn Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln 130 135 140 Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu 145 150 155 160 Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr Pro Leu 165 170 175 Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu 180 185 190 Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu 195 200 205 Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 210 215 220 His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln 225 230 235 240 Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 245 250 255 Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 260 265 270 Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 275 280 285 Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 290 295 300 Pro 305 <210> 489 <211> 320 <212> PRT <213> Homo sapiens <400> 489 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 115 120 125 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140 Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 145 150 155 160 Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 165 170 175 Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr Pro Leu Gly 180 185 190 Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln 195 200 205 Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys 210 215 220 Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 225 230 235 240 Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala 245 250 255 Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu 260 265 270 Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly 275 280 285 Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr 290 295 300 Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 305 310 315 320 <210> 490 <211> 305 <212> PRT <213> Homo sapiens <400> 490 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125 Asn Met Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala 130 135 140 Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 145 150 155 160 Leu Ala Gln Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 165 170 175 Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 180 185 190 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 195 200 205 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 210 215 220 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 225 230 235 240 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 245 250 255 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 260 265 270 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 275 280 285 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 290 295 300 Ala 305 <210> 491 <211> 320 <212> PRT <213> Homo sapiens <400> 491 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr 100 105 110 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 115 120 125 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140 Met Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser 145 150 155 160 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 165 170 175 Ala Gln Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe 180 185 190 Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala 195 200 205 Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu 210 215 220 Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu 225 230 235 240 Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln 245 250 255 Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu 260 265 270 Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp 275 280 285 Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly 290 295 300 Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala 305 310 315 320 <210> 492 <211> 321 <212> PRT <213> Homo sapiens <400> 492 Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met Asp 1 5 10 15 Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys 20 25 30 Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln 35 40 45 Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile 50 55 60 Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr 65 70 75 80 Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser Asn 85 90 95 Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro 100 105 110 Ala Pro Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser 115 120 125 Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His 130 135 140 Lys Ser Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser 145 150 155 160 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln 165 170 175 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 180 185 190 Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu 195 200 205 Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu 210 215 220 Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 225 230 235 240 His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln 245 250 255 Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 260 265 270 Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 275 280 285 Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 290 295 300 Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 305 310 315 320 Pro <210> 493 <211> 321 <212> PRT <213> Homo sapiens <400> 493 Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu 1 5 10 15 Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala 20 25 30 Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr 35 40 45 Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser Asn Cys Ser Ile 50 55 60 Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro Leu 65 70 75 80 Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met Asp 85 90 95 Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys 100 105 110 Asn Leu Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser 115 120 125 Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His 130 135 140 Lys Ser Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser 145 150 155 160 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln 165 170 175 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 180 185 190 Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu 195 200 205 Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu 210 215 220 Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 225 230 235 240 His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln 245 250 255 Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 260 265 270 Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 275 280 285 Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 290 295 300 Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 305 310 315 320 Pro <210> 494 <211> 321 <212> PRT <213> Homo sapiens <400> 494 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 1 5 10 15 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 20 25 30 Glu Gln Gln Gly Gly Gly Ser Asn Cys Ser Ile Met Ile Asp Glu Ile 35 40 45 Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn 50 55 60 Leu Asn Asp Glu Asp Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu 65 70 75 80 Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala 85 90 95 Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser 100 105 110 Ala Thr Ala Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser 115 120 125 Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His 130 135 140 Lys Ser Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser 145 150 155 160 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln 165 170 175 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 180 185 190 Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu 195 200 205 Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu 210 215 220 Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 225 230 235 240 His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln 245 250 255 Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 260 265 270 Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 275 280 285 Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 290 295 300 Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 305 310 315 320 Pro <210> 495 <211> 321 <212> PRT <213> Homo sapiens <400> 495 Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val 1 5 10 15 Thr Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser Asn Cys Ser 20 25 30 Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Ala Pro 35 40 45 Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met 50 55 60 Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val 65 70 75 80 Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu 85 90 95 Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile 100 105 110 Ile Ile Lys Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser 115 120 125 Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His 130 135 140 Lys Ser Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser 145 150 155 160 Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln 165 170 175 Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 180 185 190 Ser Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu 195 200 205 Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu 210 215 220 Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 225 230 235 240 His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln 245 250 255 Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 260 265 270 Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 275 280 285 Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 290 295 300 Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 305 310 315 320 Pro <210> 496 <211> 329 <212> PRT <213> Homo sapiens <400> 496 Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile Leu Met Asp 1 5 10 15 Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys 20 25 30 Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln 35 40 45 Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile 50 55 60 Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr 65 70 75 80 Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser Gly 85 90 95 Gly Gly Ser Gly Gly Gly Ser Asn Cys Ser Ile Met Ile Asp Glu Ile 100 105 110 Ile His His Leu Lys Arg Pro Pro Ala Pro Leu Tyr Val Glu Gly Gly 115 120 125 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 130 135 140 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Gln 145 150 155 160 Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly 165 170 175 Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg 180 185 190 Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln 195 200 205 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp 210 215 220 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His 225 230 235 240 Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala 245 250 255 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu 260 265 270 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 275 280 285 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln 290 295 300 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu 305 310 315 320 Leu Gly Met Ala Pro Ala Leu Gln Pro 325 <210> 497 <211> 329 <212> PRT <213> Homo sapiens <400> 497 Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu 1 5 10 15 Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala 20 25 30 Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr 35 40 45 Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser Gly Gly Gly Ser 50 55 60 Gly Gly Gly Ser Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His 65 70 75 80 Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp 85 90 95 Glu Asp Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu 100 105 110 Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Tyr Val Glu Gly Gly 115 120 125 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 130 135 140 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Gln 145 150 155 160 Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly 165 170 175 Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg 180 185 190 Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln 195 200 205 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp 210 215 220 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His 225 230 235 240 Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala 245 250 255 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu 260 265 270 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 275 280 285 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln 290 295 300 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu 305 310 315 320 Leu Gly Met Ala Pro Ala Leu Gln Pro 325 <210> 498 <211> 329 <212> PRT <213> Homo sapiens <400> 498 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 1 5 10 15 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 20 25 30 Glu Gln Gln Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn 35 40 45 Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro 50 55 60 Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser Ile 65 70 75 80 Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg 85 90 95 Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg 100 105 110 Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Tyr Val Glu Gly Gly 115 120 125 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 130 135 140 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Gln 145 150 155 160 Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly 165 170 175 Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg 180 185 190 Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln 195 200 205 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp 210 215 220 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His 225 230 235 240 Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala 245 250 255 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu 260 265 270 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 275 280 285 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln 290 295 300 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu 305 310 315 320 Leu Gly Met Ala Pro Ala Leu Gln Pro 325 <210> 499 <211> 329 <212> PRT <213> Homo sapiens <400> 499 Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val 1 5 10 15 Thr Leu Glu Gln Ala Gln Glu Gln Gln Gly Gly Gly Ser Gly Gly Gly 20 25 30 Ser Gly Gly Gly Ser Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His 35 40 45 His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn 50 55 60 Asp Glu Asp Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn 65 70 75 80 Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly 85 90 95 Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr 100 105 110 Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Tyr Val Glu Gly Gly 115 120 125 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 130 135 140 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Gln 145 150 155 160 Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly 165 170 175 Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg 180 185 190 Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly Ser Gly Gly Ser Gln 195 200 205 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp 210 215 220 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His 225 230 235 240 Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala 245 250 255 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu 260 265 270 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 275 280 285 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln 290 295 300 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu 305 310 315 320 Leu Gly Met Ala Pro Ala Leu Gln Pro 325 <210> 500 <211> 329 <212> PRT <213> Homo sapiens <400> 500 Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys 1 5 10 15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp 20 25 30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser 35 40 45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala 50 55 60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro 65 70 75 80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg 85 90 95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln 100 105 110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140 Pro Asn Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 145 150 155 160 Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 165 170 175 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 180 185 190 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 195 200 205 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 210 215 220 Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 225 230 235 240 Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 245 250 255 Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 260 265 270 Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Gly Gly Gly Ser 275 280 285 Asp Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe 290 295 300 Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala 305 310 315 320 Ala Leu Gln Glu Lys Leu Cys Ala Thr 325 <210> 501 <211> 329 <212> PRT <213> Homo sapiens <400> 501 Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys 1 5 10 15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp 20 25 30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser 35 40 45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala 50 55 60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro 65 70 75 80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg 85 90 95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln 100 105 110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140 Pro Asn Met Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 145 150 155 160 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 165 170 175 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 180 185 190 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 195 200 205 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 210 215 220 Gln Pro Gly Gly Gly Ser Asp Met Ala Thr Pro Leu Gly Pro Ala Ser 225 230 235 240 Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys 245 250 255 Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr 260 265 270 Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly 275 280 285 Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu 290 295 300 Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly 305 310 315 320 Leu Leu Gln Ala Leu Glu Gly Ile Ser 325 <210> 502 <211> 329 <212> PRT <213> Homo sapiens <400> 502 Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys 1 5 10 15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp 20 25 30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser 35 40 45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala 50 55 60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro 65 70 75 80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg 85 90 95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln 100 105 110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140 Pro Asn Met Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val 145 150 155 160 Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg 165 170 175 His Leu Ala Gln Pro Gly Gly Gly Ser Asp Met Ala Thr Pro Leu Gly 180 185 190 Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln 195 200 205 Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys 210 215 220 Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 225 230 235 240 Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala 245 250 255 Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu 260 265 270 Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly 275 280 285 Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr 290 295 300 Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 305 310 315 320 Thr Gln Gly Ala Met Pro Ala Phe Ala 325 <210> 503 <211> 329 <212> PRT <213> Homo sapiens <400> 503 Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys 1 5 10 15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp 20 25 30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser 35 40 45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala 50 55 60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro 65 70 75 80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg 85 90 95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln 100 105 110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140 Pro Asn Met Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val 145 150 155 160 Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg 165 170 175 His Leu Ala Gln Pro Gly Gly Gly Ser Asp Met Ala Thr Pro Leu Gly 180 185 190 Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln 195 200 205 Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys 210 215 220 Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 225 230 235 240 Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala 245 250 255 Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu 260 265 270 Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly 275 280 285 Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr 290 295 300 Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 305 310 315 320 Thr Gln Gly Ala Met Pro Ala Phe Ala 325 <210> 504 <211> 329 <212> PRT <213> Homo sapiens <400> 504 Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys 1 5 10 15 Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp 20 25 30 Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser 35 40 45 Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala 50 55 60 Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro 65 70 75 80 Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg 85 90 95 Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln 100 105 110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140 Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 145 150 155 160 Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 165 170 175 Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Gly Gly 180 185 190 Gly Ser Asp Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln 195 200 205 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp 210 215 220 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His 225 230 235 240 Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala 245 250 255 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu 260 265 270 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 275 280 285 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln 290 295 300 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu 305 310 315 320 Leu Gly Met Ala Pro Ala Leu Gln Pro 325 <210> 505 <211> 319 <212> PRT <213> Homo sapiens <400> 505 Met Ala Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys 1 5 10 15 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp 20 25 30 Gln Asp Ile Leu Met Asp Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala 35 40 45 Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser 50 55 60 Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro 65 70 75 80 Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg 85 90 95 Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln 100 105 110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140 Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 145 150 155 160 Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 165 170 175 Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly 180 185 190 Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val 195 200 205 Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala 210 215 220 Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser 225 230 235 240 Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu 245 250 255 Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr 260 265 270 Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro 275 280 285 Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile 290 295 300 Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 305 310 315 <210> 506 <211> 322 <212> PRT <213> Homo sapiens <400> 506 Met Ala Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys 1 5 10 15 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp 20 25 30 Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala 35 40 45 Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser 50 55 60 Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro 65 70 75 80 Thr Arg His Pro Ile Ile Ile Arg Asp Gly Asp Trp Asn Glu Phe Arg 85 90 95 Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln 100 105 110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140 Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 145 150 155 160 Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 165 170 175 Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr Pro 180 185 190 Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu 195 200 205 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 210 215 220 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240 Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 260 265 270 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 275 280 285 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 290 295 300 Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320 Gln Pro <210> 507 <211> 319 <212> PRT <213> Homo sapiens <400> 507 Met Ala Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys 1 5 10 15 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp 20 25 30 Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala 35 40 45 Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser 50 55 60 Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro 65 70 75 80 Thr Arg His Pro Ile Ile Ile Arg Asp Gly Asp Trp Asn Glu Phe Arg 85 90 95 Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln 100 105 110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140 Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 145 150 155 160 Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 165 170 175 Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly 180 185 190 Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val 195 200 205 Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala 210 215 220 Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser 225 230 235 240 Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu 245 250 255 Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr 260 265 270 Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro 275 280 285 Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile 290 295 300 Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 305 310 315 <210> 508 <211> 322 <212> PRT <213> Homo sapiens <400> 508 Met Ala Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys 1 5 10 15 Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp 20 25 30 Gln Asp Ile Leu Met Asp Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala 35 40 45 Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser 50 55 60 Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro 65 70 75 80 Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg 85 90 95 Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln 100 105 110 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140 Pro Asn Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 145 150 155 160 Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 165 170 175 Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Thr Pro 180 185 190 Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu 195 200 205 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 210 215 220 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240 Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 260 265 270 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 275 280 285 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 290 295 300 Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320 Gln Pro <210> 509 <211> 306 <212> PRT <213> Homo sapiens <400> 509 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val 145 150 155 160 Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala 165 170 175 Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala 180 185 190 Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln 195 200 205 Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu 210 215 220 Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro 225 230 235 240 Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg 245 250 255 Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly 260 265 270 Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu 275 280 285 Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln 290 295 300 Cys Pro 305 <210> 510 <211> 306 <212> PRT <213> Homo sapiens <400> 510 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 145 150 155 160 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 165 170 175 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 180 185 190 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 195 200 205 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu 210 215 220 Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 225 230 235 240 Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 245 250 255 Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Met Ala 260 265 270 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 275 280 285 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 290 295 300 His Pro 305 <210> 511 <211> 306 <212> PRT <213> Homo sapiens <400> 511 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys 145 150 155 160 Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr 165 170 175 Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr 180 185 190 Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu 195 200 205 Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly 210 215 220 Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln 225 230 235 240 His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser 245 250 255 Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Met Ala Ser Pro Ala Pro 260 265 270 Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His 275 280 285 Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro 290 295 300 Thr Pro 305 <210> 512 <211> 306 <212> PRT <213> Homo sapiens <400> 512 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu 145 150 155 160 Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu 165 170 175 Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser 180 185 190 Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu 195 200 205 Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala 210 215 220 His Lys Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg 225 230 235 240 Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 245 250 255 Arg Glu Phe Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp 260 265 270 Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser 275 280 285 Arg Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu 290 295 300 Leu Pro 305 <210> 513 <211> 306 <212> PRT <213> Homo sapiens <400> 513 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr 145 150 155 160 Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val 165 170 175 Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu 180 185 190 Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser 195 200 205 Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys 210 215 220 Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys 225 230 235 240 Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu 245 250 255 Phe Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg 260 265 270 Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu 275 280 285 Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro 290 295 300 Ala Val 305 <210> 514 <211> 306 <212> PRT <213> Homo sapiens <400> 514 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp 145 150 155 160 Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg 165 170 175 Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser 180 185 190 Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr 195 200 205 Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala 210 215 220 Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu 225 230 235 240 Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn 245 250 255 Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys 260 265 270 Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro 275 280 285 Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe 290 295 300 Ser Leu 305 <210> 515 <211> 306 <212> PRT <213> Homo sapiens <400> 515 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly 145 150 155 160 Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln 165 170 175 Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile 180 185 190 Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met 195 200 205 Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Met 210 215 220 Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu 225 230 235 240 Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu 245 250 255 Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser 260 265 270 Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile 275 280 285 Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly 290 295 300 Gln Leu 305 <210> 516 <211> 306 <212> PRT <213> Homo sapiens <400> 516 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys 145 150 155 160 Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys 165 170 175 Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu 180 185 190 Phe Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg 195 200 205 Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu 210 215 220 Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro 225 230 235 240 Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr 245 250 255 Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val 260 265 270 Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu 275 280 285 Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser 290 295 300 Leu Leu 305 <210> 517 <211> 306 <212> PRT <213> Homo sapiens <400> 517 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe Leu 145 150 155 160 Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val 165 170 175 Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Met Ala Ser 180 185 190 Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg 195 200 205 Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val His 210 215 220 Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly 225 230 235 240 Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu Gly 245 250 255 Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln Leu 260 265 270 Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln Val 275 280 285 Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu Pro 290 295 300 Pro Gln 305 <210> 518 <211> 306 <212> PRT <213> Homo sapiens <400> 518 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala His Lys Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His 145 150 155 160 Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr 165 170 175 Leu Cys Val Arg Glu Phe Gly Gly Asn Met Ala Ser Pro Ala Pro Pro 180 185 190 Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val 195 200 205 Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr 210 215 220 Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr 225 230 235 240 Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu 245 250 255 Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys 260 265 270 Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu 275 280 285 Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg 290 295 300 Thr Thr 305 <210> 519 <211> 306 <212> PRT <213> Homo sapiens <400> 519 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg 145 150 155 160 Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 165 170 175 Arg Glu Phe Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp 180 185 190 Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser 195 200 205 Arg Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu 210 215 220 Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu 225 230 235 240 Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu 245 250 255 Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser 260 265 270 Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu 275 280 285 Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala 290 295 300 His Lys 305 <210> 520 <211> 306 <212> PRT <213> Homo sapiens <400> 520 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val 145 150 155 160 Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe 165 170 175 Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val 180 185 190 Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser 195 200 205 Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala 210 215 220 Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys 225 230 235 240 Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met 245 250 255 Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly 260 265 270 Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu 275 280 285 Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp 290 295 300 Pro Asn 305 <210> 521 <211> 305 <212> PRT <213> Homo sapiens <400> 521 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val 145 150 155 160 Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala 165 170 175 Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala 180 185 190 Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln 195 200 205 Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu 210 215 220 Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro 225 230 235 240 Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg 245 250 255 Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly 260 265 270 Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser 275 280 285 Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys 290 295 300 Pro 305 <210> 522 <211> 305 <212> PRT <213> Homo sapiens <400> 522 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 145 150 155 160 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 165 170 175 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 180 185 190 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 195 200 205 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu 210 215 220 Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 225 230 235 240 Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 245 250 255 Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Asn Met Ala Ser 260 265 270 Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg 275 280 285 Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val His 290 295 300 Pro 305 <210> 523 <211> 305 <212> PRT <213> Homo sapiens <400> 523 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys 145 150 155 160 Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr 165 170 175 Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr 180 185 190 Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu 195 200 205 Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly 210 215 220 Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln 225 230 235 240 His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser 245 250 255 Thr Leu Cys Val Arg Glu Phe Gly Asn Met Ala Ser Pro Ala Pro Pro 260 265 270 Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val 275 280 285 Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr 290 295 300 Pro 305 <210> 524 <211> 305 <212> PRT <213> Homo sapiens <400> 524 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu 145 150 155 160 Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu 165 170 175 Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser 180 185 190 Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu 195 200 205 Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala 210 215 220 His Lys Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg 225 230 235 240 Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 245 250 255 Arg Glu Phe Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu 260 265 270 Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg 275 280 285 Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu 290 295 300 Pro 305 <210> 525 <211> 305 <212> PRT <213> Homo sapiens <400> 525 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr 145 150 155 160 Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val 165 170 175 Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu 180 185 190 Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser 195 200 205 Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys 210 215 220 Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys 225 230 235 240 Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu 245 250 255 Phe Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val 260 265 270 Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser 275 280 285 Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala 290 295 300 Val 305 <210> 526 <211> 305 <212> PRT <213> Homo sapiens <400> 526 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp 145 150 155 160 Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg 165 170 175 Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser 180 185 190 Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr 195 200 205 Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala 210 215 220 Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu 225 230 235 240 Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Asn Met 245 250 255 Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu 260 265 270 Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu 275 280 285 Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser 290 295 300 Leu 305 <210> 527 <211> 305 <212> PRT <213> Homo sapiens <400> 527 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly 145 150 155 160 Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln 165 170 175 Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile 180 185 190 Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met 195 200 205 Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Asn Met Ala 210 215 220 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 225 230 235 240 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 245 250 255 His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 260 265 270 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 275 280 285 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 290 295 300 Leu 305 <210> 528 <211> 305 <212> PRT <213> Homo sapiens <400> 528 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys 145 150 155 160 Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys 165 170 175 Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu 180 185 190 Phe Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val 195 200 205 Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser 210 215 220 Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala 225 230 235 240 Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys 245 250 255 Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met 260 265 270 Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly 275 280 285 Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu 290 295 300 Leu 305 <210> 529 <211> 305 <212> PRT <213> Homo sapiens <400> 529 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe Leu 145 150 155 160 Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val 165 170 175 Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Asn Met Ala Ser Pro 180 185 190 Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp 195 200 205 Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val His Pro 210 215 220 Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu 225 230 235 240 Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala 245 250 255 Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln Leu Gly 260 265 270 Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln Val Arg 275 280 285 Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro 290 295 300 Gln 305 <210> 530 <211> 305 <212> PRT <213> Homo sapiens <400> 530 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala His Lys Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His 145 150 155 160 Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr 165 170 175 Leu Cys Val Arg Glu Phe Gly Asn Met Ala Ser Pro Ala Pro Pro Ala 180 185 190 Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu 195 200 205 His Ser Arg Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro 210 215 220 Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln 225 230 235 240 Met Glu Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu 245 250 255 Leu Glu Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu 260 265 270 Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly 275 280 285 Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr 290 295 300 Thr 305 <210> 531 <211> 305 <212> PRT <213> Homo sapiens <400> 531 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg 145 150 155 160 Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 165 170 175 Arg Glu Phe Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu 180 185 190 Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg 195 200 205 Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu 210 215 220 Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu 225 230 235 240 Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly 245 250 255 Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu 260 265 270 Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln 275 280 285 Ser Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His 290 295 300 Lys 305 <210> 532 <211> 305 <212> PRT <213> Homo sapiens <400> 532 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val 145 150 155 160 Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe 165 170 175 Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu 180 185 190 Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln 195 200 205 Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val 210 215 220 Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala 225 230 235 240 Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala 245 250 255 Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln 260 265 270 Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu 275 280 285 Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro 290 295 300 Asn 305 <210> 533 <211> 309 <212> PRT <213> Homo sapiens <400> 533 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val 145 150 155 160 Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala 165 170 175 Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala 180 185 190 Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln 195 200 205 Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu 210 215 220 Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro 225 230 235 240 Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg 245 250 255 Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly 260 265 270 Gly Asn Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu 275 280 285 Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg 290 295 300 Leu Ser Gln Cys Pro 305 <210> 534 <211> 309 <212> PRT <213> Homo sapiens <400> 534 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 145 150 155 160 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 165 170 175 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 180 185 190 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 195 200 205 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu 210 215 220 Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 225 230 235 240 Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 245 250 255 Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Gly Gly 260 265 270 Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser 275 280 285 Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys 290 295 300 Pro Glu Val His Pro 305 <210> 535 <211> 309 <212> PRT <213> Homo sapiens <400> 535 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys 145 150 155 160 Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr 165 170 175 Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr 180 185 190 Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu 195 200 205 Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly 210 215 220 Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln 225 230 235 240 His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser 245 250 255 Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Gly Gly Asn Met Ala Ser 260 265 270 Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg 275 280 285 Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val His 290 295 300 Pro Leu Pro Thr Pro 305 <210> 536 <211> 309 <212> PRT <213> Homo sapiens <400> 536 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu 145 150 155 160 Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu 165 170 175 Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser 180 185 190 Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu 195 200 205 Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala 210 215 220 His Lys Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg 225 230 235 240 Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 245 250 255 Arg Glu Phe Gly Gly Asn Gly Gly Asn Met Ala Ser Pro Ala Pro Pro 260 265 270 Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val 275 280 285 Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr 290 295 300 Pro Val Leu Leu Pro 305 <210> 537 <211> 309 <212> PRT <213> Homo sapiens <400> 537 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr 145 150 155 160 Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val 165 170 175 Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu 180 185 190 Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser 195 200 205 Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys 210 215 220 Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys 225 230 235 240 Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu 245 250 255 Phe Gly Gly Asn Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys 260 265 270 Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His 275 280 285 Ser Arg Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val 290 295 300 Leu Leu Pro Ala Val 305 <210> 538 <211> 309 <212> PRT <213> Homo sapiens <400> 538 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp 145 150 155 160 Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg 165 170 175 Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser 180 185 190 Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr 195 200 205 Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala 210 215 220 Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu 225 230 235 240 Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn 245 250 255 Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val 260 265 270 Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser 275 280 285 Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala 290 295 300 Val Asp Phe Ser Leu 305 <210> 539 <211> 309 <212> PRT <213> Homo sapiens <400> 539 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly 145 150 155 160 Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln 165 170 175 Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile 180 185 190 Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met 195 200 205 Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Gly 210 215 220 Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu 225 230 235 240 Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln 245 250 255 Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val 260 265 270 Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala 275 280 285 Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala 290 295 300 Ala Arg Gly Gln Leu 305 <210> 540 <211> 309 <212> PRT <213> Homo sapiens <400> 540 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala His Lys 145 150 155 160 Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys 165 170 175 Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu 180 185 190 Phe Gly Gly Asn Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys 195 200 205 Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His 210 215 220 Ser Arg Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val 225 230 235 240 Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met 245 250 255 Glu Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu 260 265 270 Glu Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser 275 280 285 Ser Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala 290 295 300 Leu Gln Ser Leu Leu 305 <210> 541 <211> 309 <212> PRT <213> Homo sapiens <400> 541 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe Leu 145 150 155 160 Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val 165 170 175 Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Gly Gly Asn 180 185 190 Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys 195 200 205 Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro 210 215 220 Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe 225 230 235 240 Ser Leu Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp 245 250 255 Ile Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg 260 265 270 Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser 275 280 285 Gly Gln Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr 290 295 300 Gln Leu Pro Pro Gln 305 <210> 542 <211> 309 <212> PRT <213> Homo sapiens <400> 542 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala His Lys Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His 145 150 155 160 Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr 165 170 175 Leu Cys Val Arg Glu Phe Gly Gly Asn Gly Gly Asn Met Ala Ser Pro 180 185 190 Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp 195 200 205 Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val His Pro 210 215 220 Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu 225 230 235 240 Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala 245 250 255 Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln Leu Gly 260 265 270 Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln Val Arg 275 280 285 Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro 290 295 300 Gln Gly Arg Thr Thr 305 <210> 543 <211> 309 <212> PRT <213> Homo sapiens <400> 543 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg 145 150 155 160 Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 165 170 175 Arg Glu Phe Gly Gly Asn Gly Gly Asn Met Ala Ser Pro Ala Pro Pro 180 185 190 Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val 195 200 205 Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr 210 215 220 Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr 225 230 235 240 Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu 245 250 255 Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys 260 265 270 Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu 275 280 285 Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg 290 295 300 Thr Thr Ala His Lys 305 <210> 544 <211> 309 <212> PRT <213> Homo sapiens <400> 544 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val 145 150 155 160 Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe 165 170 175 Gly Gly Asn Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp 180 185 190 Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser 195 200 205 Arg Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu 210 215 220 Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu 225 230 235 240 Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu 245 250 255 Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser 260 265 270 Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu 275 280 285 Gln Ser Leu Leu Gly Thr Gln Leu Pro Pro Gln Gly Arg Thr Thr Ala 290 295 300 His Lys Asp Pro Asn 305 <210> 545 <211> 302 <212> PRT <213> Homo sapiens <400> 545 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln His Leu Leu Arg 145 150 155 160 Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 165 170 175 Arg Glu Phe Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp 180 185 190 Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser 195 200 205 Arg Leu Ser Gln Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu 210 215 220 Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gln Met Glu 225 230 235 240 Glu Thr Lys Ala Gln Asp Ile Leu Gly Ala Val Thr Leu Leu Leu Glu 245 250 255 Gly Val Met Ala Ala Arg Gly Gln Leu Gly Pro Thr Cys Leu Ser Ser 260 265 270 Leu Leu Gly Gln Leu Ser Gly Gln Val Arg Leu Leu Leu Gly Ala Leu 275 280 285 Gln Ser Leu Leu Gly Thr Gln Gly Arg Thr Thr Ala His Lys 290 295 300 <210> 546 <211> 153 <212> PRT <213> Homo sapiens <400> 546 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 1 5 10 15 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 20 25 30 His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 50 55 60 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 65 70 75 80 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 85 90 95 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu 100 105 110 Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 115 120 125 Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140 Val Gly Gly Ser Thr Leu Cys Val Arg 145 150 <210> 547 <211> 149 <212> PRT <213> Homo sapiens <400> 547 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 1 5 10 15 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 20 25 30 His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 50 55 60 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 65 70 75 80 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 85 90 95 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Gly 100 105 110 Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe Leu Ser Phe Gln 115 120 125 His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser 130 135 140 Thr Leu Cys Val Arg 145 <210> 548 <211> 153 <212> PRT <213> Homo sapiens <400> 548 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 1 5 10 15 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 20 25 30 His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 50 55 60 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 65 70 75 80 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 85 90 95 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Leu 100 105 110 Pro Pro Gln Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 115 120 125 Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140 Val Gly Gly Ser Thr Leu Cys Val Arg 145 150 <210> 549 <211> 135 <212> PRT <213> Homo sapiens <400> 549 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Ala Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro 130 135 <210> 550 <211> 140 <212> PRT <213> Homo sapiens <400> 550 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 130 135 140 <210> 551 <211> 122 <212> PRT <213> Homo sapiens <400> 551 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Glu Thr Ser Glu Gln Leu Val 85 90 95 Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu 100 105 110 Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 115 120 <210> 552 <211> 135 <212> PRT <213> Homo sapiens <400> 552 Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro 130 135 <210> 553 <211> 140 <212> PRT <213> Homo sapiens <400> 553 Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 130 135 140 <210> 554 <211> 135 <212> PRT <213> Homo sapiens <400> 554 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro 130 135 <210> 555 <211> 140 <212> PRT <213> Homo sapiens <400> 555 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 130 135 140 <210> 556 <211> 155 <212> PRT <213> Homo sapiens <400> 556 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Ser 100 105 110 Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 115 120 125 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 130 135 140 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 145 150 155 <210> 557 <211> 150 <212> PRT <213> Homo sapiens <400> 557 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Thr 100 105 110 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 115 120 125 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 130 135 140 Val Ala Ser Asn Leu Gln 145 150 <210> 558 <211> 145 <212> PRT <213> Homo sapiens <400> 558 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe 100 105 110 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 115 120 125 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 130 135 140 Gln 145 <210> 559 <211> 155 <212> PRT <213> Homo sapiens <400> 559 Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 1 5 10 15 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 35 40 45 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 50 55 60 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly 65 70 75 80 Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe 85 90 95 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 100 105 110 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 130 135 140 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 145 150 155 <210> 560 <211> 150 <212> PRT <213> Homo sapiens <400> 560 Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 1 5 10 15 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 35 40 45 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 50 55 60 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly 65 70 75 80 Ser Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 85 90 95 Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu 100 105 110 Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu 115 120 125 Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg 130 135 140 Leu Lys Thr Val Ala Gly 145 150 <210> 561 <211> 145 <212> PRT <213> Homo sapiens <400> 561 Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 1 5 10 15 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 35 40 45 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 50 55 60 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly 65 70 75 80 Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 85 90 95 Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 100 105 110 Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 115 120 125 Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 130 135 140 Gly 145 <210> 562 <211> 155 <212> PRT <213> Homo sapiens <400> 562 Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 1 5 10 15 Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 20 25 30 Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 35 40 45 Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Ser Gly Gly 50 55 60 Asn Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 65 70 75 80 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 85 90 95 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 100 105 110 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 115 120 125 Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 130 135 140 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 145 150 155 <210> 563 <211> 150 <212> PRT <213> Homo sapiens <400> 563 Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 1 5 10 15 Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 20 25 30 Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 35 40 45 Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Thr Gln Asp 50 55 60 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 65 70 75 80 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 85 90 95 Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 100 105 110 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 115 120 125 Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr 130 135 140 Lys Cys Ala Phe Gln Pro 145 150 <210> 564 <211> 145 <212> PRT <213> Homo sapiens <400> 564 Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 1 5 10 15 Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 20 25 30 Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 35 40 45 Ser Thr Leu Ser Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe Gln His 50 55 60 Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp 65 70 75 80 Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp 85 90 95 Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp 100 105 110 Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu 115 120 125 Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln 130 135 140 Pro 145 <210> 565 <211> 155 <212> PRT <213> Homo sapiens <400> 565 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser 100 105 110 Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 115 120 125 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 130 135 140 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 145 150 155 <210> 566 <211> 150 <212> PRT <213> Homo sapiens <400> 566 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Thr 100 105 110 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 115 120 125 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 130 135 140 Val Ala Ser Asn Leu Gln 145 150 <210> 567 <211> 145 <212> PRT <213> Homo sapiens <400> 567 Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 1 5 10 15 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 20 25 30 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 35 40 45 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 50 55 60 Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 65 70 75 80 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 85 90 95 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 100 105 110 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 115 120 125 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly 130 135 140 Ser 145 <210> 568 <211> 143 <212> PRT <213> Homo sapiens <400> 568 Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 1 5 10 15 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 20 25 30 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys 35 40 45 Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu 50 55 60 Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn 65 70 75 80 Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser 85 90 95 Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr 100 105 110 Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe 115 120 125 Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 130 135 140 <210> 569 <211> 149 <212> PRT <213> Homo sapiens <400> 569 Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 1 5 10 15 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 20 25 30 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 35 40 45 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 50 55 60 Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 65 70 75 80 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 85 90 95 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 100 105 110 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 115 120 125 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly 130 135 140 Ser Gly Gly Gly Ser 145 <210> 570 <211> 144 <212> PRT <213> Homo sapiens <400> 570 Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 1 5 10 15 Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu 20 25 30 Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu 35 40 45 Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg 50 55 60 Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 65 70 75 80 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 85 90 95 Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 100 105 110 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 115 120 125 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 130 135 140 <210> 571 <211> 153 <212> PRT <213> Homo sapiens <400> 571 Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 1 5 10 15 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 20 25 30 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 35 40 45 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 50 55 60 Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 65 70 75 80 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 85 90 95 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 100 105 110 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 115 120 125 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly 130 135 140 Ser Gly Gly Gly Ser Gly Gly Gly Ser 145 150 <210> 572 <211> 150 <212> PRT <213> Homo sapiens <400> 572 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser 1 5 10 15 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 20 25 30 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 35 40 45 Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 50 55 60 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 65 70 75 80 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 85 90 95 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 100 105 110 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 115 120 125 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 130 135 140 Pro Asp Ser Ser Thr Leu 145 150 <210> 573 <211> 146 <212> PRT <213> Homo sapiens <400> 573 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser 100 105 110 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 115 120 125 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 130 135 140 Leu Gln 145 <210> 574 <211> 147 <212> PRT <213> Homo sapiens <400> 574 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys 100 105 110 Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 115 120 125 Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser 130 135 140 Asn Leu Gln 145 <210> 575 <211> 150 <212> PRT <213> Homo sapiens <400> 575 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr 100 105 110 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 115 120 125 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 130 135 140 Val Ala Ser Asn Leu Gln 145 150 <210> 576 <211> 153 <212> PRT <213> Homo sapiens <400> 576 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 115 120 125 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 130 135 140 Pro Val Thr Val Ala Ser Asn Leu Gln 145 150 <210> 577 <211> 155 <212> PRT <213> Homo sapiens <400> 577 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 115 120 125 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 130 135 140 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 145 150 155 <210> 578 <211> 161 <212> PRT <213> Homo sapiens <400> 578 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln <210> 579 <211> 281 <212> PRT <213> Homo sapiens <400> 579 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 145 150 155 160 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 165 170 175 Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly 180 185 190 Ala Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys 195 200 205 Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr 210 215 220 Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys 225 230 235 240 Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser 245 250 255 Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser 260 265 270 Arg Cys Leu Glu Leu Gln Cys Gln Pro 275 280 <210> 580 <211> 286 <212> PRT <213> Homo sapiens <400> 580 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 145 150 155 160 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 165 170 175 Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly 180 185 190 Ala Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys 195 200 205 Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr 210 215 220 Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys 225 230 235 240 Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser 245 250 255 Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser 260 265 270 Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 275 280 285 <210> 581 <211> 296 <212> PRT <213> Homo sapiens <400> 581 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn 245 250 255 Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 260 265 270 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 275 280 285 Val Thr Val Ala Ser Asn Leu Gln 290 295 <210> 582 <211> 296 <212> PRT <213> Homo sapiens <400> 582 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn 245 250 255 Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 260 265 270 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 275 280 285 Val Thr Val Ala Ser Asn Leu Gln 290 295 <210> 583 <211> 291 <212> PRT <213> Homo sapiens <400> 583 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 165 170 175 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 180 185 190 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 195 200 205 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly 210 215 220 Asn Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 225 230 235 240 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 245 250 255 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 260 265 270 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 275 280 285 Val Ala Gly 290 <210> 584 <211> 296 <212> PRT <213> Homo sapiens <400> 584 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 165 170 175 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 180 185 190 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 195 200 205 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly 210 215 220 Asn Gly Ser Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe Gln His Ser 225 230 235 240 Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr 245 250 255 Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 260 265 270 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 275 280 285 Glu Arg Leu Lys Thr Val Ala Gly 290 295 <210> 585 <211> 301 <212> PRT <213> Homo sapiens <400> 585 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn 245 250 255 Gly Ser Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro 260 265 270 Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 275 280 285 Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 290 295 300 <210> 586 <211> 291 <212> PRT <213> Homo sapiens <400> 586 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 145 150 155 160 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 165 170 175 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 180 185 190 Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe 195 200 205 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 210 215 220 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 225 230 235 240 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 245 250 255 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 260 265 270 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 275 280 285 Phe Gln Pro 290 <210> 587 <211> 296 <212> PRT <213> Homo sapiens <400> 587 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 145 150 155 160 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 165 170 175 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 180 185 190 Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Thr 195 200 205 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 210 215 220 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 225 230 235 240 Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 245 250 255 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 260 265 270 Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe 275 280 285 Val Thr Lys Cys Ala Phe Gln Pro 290 295 <210> 588 <211> 301 <212> PRT <213> Homo sapiens <400> 588 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 145 150 155 160 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 165 170 175 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 180 185 190 Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Ser 195 200 205 Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 210 215 220 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 225 230 235 240 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys 245 250 255 Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu 260 265 270 Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn 275 280 285 Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 290 295 300 <210> 589 <211> 281 <212> PRT <213> Homo sapiens <400> 589 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 145 150 155 160 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 165 170 175 Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly 180 185 190 Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys 195 200 205 Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr 210 215 220 Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys 225 230 235 240 Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser 245 250 255 Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser 260 265 270 Arg Cys Leu Glu Leu Gln Cys Gln Pro 275 280 <210> 590 <211> 286 <212> PRT <213> Homo sapiens <400> 590 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 145 150 155 160 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 165 170 175 Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly 180 185 190 Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys 195 200 205 Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr 210 215 220 Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys 225 230 235 240 Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser 245 250 255 Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser 260 265 270 Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 275 280 285 <210> 591 <211> 296 <212> PRT <213> Homo sapiens <400> 591 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn 245 250 255 Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 260 265 270 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 275 280 285 Val Thr Val Ala Ser Asn Leu Gln 290 295 <210> 592 <211> 301 <212> PRT <213> Homo sapiens <400> 592 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn 245 250 255 Gly Ser Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro 260 265 270 Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 275 280 285 Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 290 295 300 <210> 593 <211> 291 <212> PRT <213> Homo sapiens <400> 593 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 165 170 175 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 180 185 190 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 195 200 205 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly 210 215 220 Asn Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 225 230 235 240 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 245 250 255 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 260 265 270 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 275 280 285 Val Ala Gly 290 <210> 594 <211> 296 <212> PRT <213> Homo sapiens <400> 594 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 165 170 175 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 180 185 190 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 195 200 205 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly 210 215 220 Asn Gly Ser Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe Gln His Ser 225 230 235 240 Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr 245 250 255 Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 260 265 270 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 275 280 285 Glu Arg Leu Lys Thr Val Ala Gly 290 295 <210> 595 <211> 301 <212> PRT <213> Homo sapiens <400> 595 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 165 170 175 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 180 185 190 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 195 200 205 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly 210 215 220 Asn Gly Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Thr Gln Asp Cys 225 230 235 240 Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 245 250 255 Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser 260 265 270 Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 275 280 285 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 290 295 300 <210> 596 <211> 291 <212> PRT <213> Homo sapiens <400> 596 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 145 150 155 160 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 165 170 175 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 180 185 190 Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe 195 200 205 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 210 215 220 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 225 230 235 240 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 245 250 255 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 260 265 270 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 275 280 285 Phe Gln Pro 290 <210> 597 <211> 296 <212> PRT <213> Homo sapiens <400> 597 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 145 150 155 160 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 165 170 175 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 180 185 190 Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Thr 195 200 205 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 210 215 220 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 225 230 235 240 Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 245 250 255 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 260 265 270 Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe 275 280 285 Val Thr Lys Cys Ala Phe Gln Pro 290 295 <210> 598 <211> 301 <212> PRT <213> Homo sapiens <400> 598 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 145 150 155 160 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 165 170 175 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 180 185 190 Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Ser 195 200 205 Gly Gly Asn Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 210 215 220 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 225 230 235 240 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys 245 250 255 Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu 260 265 270 Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn 275 280 285 Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 290 295 300 <210> 599 <211> 296 <212> PRT <213> Homo sapiens <400> 599 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly Ser Gly Ser Gly Gly Ser 245 250 255 Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 260 265 270 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 275 280 285 Val Thr Val Ala Ser Asn Leu Gln 290 295 <210> 600 <211> 301 <212> PRT <213> Homo sapiens <400> 600 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Ser Gly Gly Ser Gly Ser Gly Gly Ser 245 250 255 Gly Ser Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro 260 265 270 Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 275 280 285 Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 290 295 300 <210> 601 <211> 281 <212> PRT <213> Homo sapiens <400> 601 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro Tyr Val Glu Gly Gly Gly Gly Ser Pro 130 135 140 Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser 145 150 155 160 Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys Ser Ile Met Ile 165 170 175 Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp 180 185 190 Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn 195 200 205 Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu 210 215 220 Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys 225 230 235 240 Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys 245 250 255 Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val 260 265 270 Thr Leu Glu Gln Ala Gln Glu Gln Gln 275 280 <210> 602 <211> 286 <212> PRT <213> Homo sapiens <400> 602 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140 Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn 145 150 155 160 Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn 165 170 175 Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro 180 185 190 Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile 195 200 205 Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg 210 215 220 Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg 225 230 235 240 Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His 245 250 255 Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu 260 265 270 Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 275 280 285 <210> 603 <211> 268 <212> PRT <213> Homo sapiens <400> 603 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Pro His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 145 150 155 160 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 165 170 175 Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly 180 185 190 Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys 195 200 205 Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr 210 215 220 Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Glu Thr Ser Glu Gln 225 230 235 240 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 245 250 255 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 260 265 <210> 604 <211> 292 <212> PRT <213> Homo sapiens <400> 604 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Thr Gln Asp 245 250 255 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 260 265 270 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 275 280 285 Ser Asn Leu Gln 290 <210> 605 <211> 293 <212> PRT <213> Homo sapiens <400> 605 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Thr Gln 245 250 255 Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys 260 265 270 Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val 275 280 285 Ala Ser Asn Leu Gln 290 <210> 606 <211> 296 <212> PRT <213> Homo sapiens <400> 606 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 245 250 255 Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 260 265 270 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 275 280 285 Val Thr Val Ala Ser Asn Leu Gln 290 295 <210> 607 <211> 299 <212> PRT <213> Homo sapiens <400> 607 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 245 250 255 Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 260 265 270 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 275 280 285 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 290 295 <210> 608 <211> 301 <212> PRT <213> Homo sapiens <400> 608 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 245 250 255 Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro 260 265 270 Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 275 280 285 Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 290 295 300 <210> 609 <211> 307 <212> PRT <213> Homo sapiens <400> 609 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 245 250 255 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys 260 265 270 Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 275 280 285 Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser 290 295 300 Asn Leu Gln 305 <210> 610 <211> 292 <212> PRT <213> Homo sapiens <400> 610 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 165 170 175 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 180 185 190 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 195 200 205 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly 210 215 220 Ser Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 225 230 235 240 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 245 250 255 Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly 260 265 270 Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys 275 280 285 Thr Val Ala Gly 290 <210> 611 <211> 293 <212> PRT <213> Homo sapiens <400> 611 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 165 170 175 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 180 185 190 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 195 200 205 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly 210 215 220 Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 225 230 235 240 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 245 250 255 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys 260 265 270 Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu 275 280 285 Lys Thr Val Ala Gly 290 <210> 612 <211> 296 <212> PRT <213> Homo sapiens <400> 612 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 165 170 175 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 180 185 190 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 195 200 205 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly 210 215 220 Ser Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser 225 230 235 240 Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr 245 250 255 Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 260 265 270 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 275 280 285 Glu Arg Leu Lys Thr Val Ala Gly 290 295 <210> 613 <211> 299 <212> PRT <213> Homo sapiens <400> 613 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 165 170 175 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 180 185 190 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 195 200 205 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly 210 215 220 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 225 230 235 240 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 245 250 255 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 260 265 270 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 275 280 285 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 290 295 <210> 614 <211> 301 <212> PRT <213> Homo sapiens <400> 614 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 165 170 175 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 180 185 190 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 195 200 205 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly 210 215 220 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys 225 230 235 240 Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 245 250 255 Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser 260 265 270 Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 275 280 285 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 290 295 300 <210> 615 <211> 307 <212> PRT <213> Homo sapiens <400> 615 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 165 170 175 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 180 185 190 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 195 200 205 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly 210 215 220 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 225 230 235 240 Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 245 250 255 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 260 265 270 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 275 280 285 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 290 295 300 Val Ala Gly 305 <210> 616 <211> 292 <212> PRT <213> Homo sapiens <400> 616 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 145 150 155 160 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 165 170 175 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 180 185 190 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser 195 200 205 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 210 215 220 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 225 230 235 240 Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 245 250 255 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 260 265 270 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 275 280 285 Ala Phe Gln Pro 290 <210> 617 <211> 293 <212> PRT <213> Homo sapiens <400> 617 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 145 150 155 160 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 165 170 175 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 180 185 190 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys 195 200 205 Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 210 215 220 Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser 225 230 235 240 Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 245 250 255 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 260 265 270 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 275 280 285 Cys Ala Phe Gln Pro 290 <210> 618 <211> 296 <212> PRT <213> Homo sapiens <400> 618 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 145 150 155 160 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 165 170 175 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 180 185 190 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr 195 200 205 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 210 215 220 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 225 230 235 240 Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 245 250 255 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 260 265 270 Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe 275 280 285 Val Thr Lys Cys Ala Phe Gln Pro 290 295 <210> 619 <211> 299 <212> PRT <213> Homo sapiens <400> 619 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 145 150 155 160 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 165 170 175 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 180 185 190 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 195 200 205 Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 210 215 220 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 225 230 235 240 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 245 250 255 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 260 265 270 Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 275 280 285 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 290 295 <210> 620 <211> 301 <212> PRT <213> Homo sapiens <400> 620 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 145 150 155 160 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 165 170 175 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 180 185 190 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 195 200 205 Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 210 215 220 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 225 230 235 240 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys 245 250 255 Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu 260 265 270 Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn 275 280 285 Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 290 295 300 <210> 621 <211> 307 <212> PRT <213> Homo sapiens <400> 621 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 145 150 155 160 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 165 170 175 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 180 185 190 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 195 200 205 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 210 215 220 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 225 230 235 240 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 245 250 255 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 260 265 270 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 275 280 285 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 290 295 300 Phe Gln Pro 305 <210> 622 <211> 296 <212> PRT <213> Homo sapiens <400> 622 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 145 150 155 160 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 165 170 175 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 180 185 190 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 195 200 205 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 210 215 220 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 225 230 235 240 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser 245 250 255 Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys 260 265 270 Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 275 280 285 Glu Leu Ser Asp Tyr Leu Leu Gln 290 295 <210> 623 <211> 301 <212> PRT <213> Homo sapiens <400> 623 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 145 150 155 160 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 165 170 175 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 180 185 190 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 195 200 205 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 210 215 220 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 225 230 235 240 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser 245 250 255 Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 260 265 270 Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 275 280 285 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 290 295 300 <210> 624 <211> 296 <212> PRT <213> Homo sapiens <400> 624 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 180 185 190 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 195 200 205 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 210 215 220 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 225 230 235 240 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255 Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro 260 265 270 Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 275 280 285 Leu Gln Asp Tyr Pro Val Thr Val 290 295 <210> 625 <211> 301 <212> PRT <213> Homo sapiens <400> 625 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 180 185 190 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 195 200 205 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 210 215 220 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 225 230 235 240 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser 260 265 270 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 275 280 285 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val 290 295 300 <210> 626 <211> 296 <212> PRT <213> Homo sapiens <400> 626 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 145 150 155 160 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 165 170 175 Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 180 185 190 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 195 200 205 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 210 215 220 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe 225 230 235 240 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 245 250 255 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 260 265 270 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 275 280 285 Arg Trp Met Glu Arg Leu Lys Thr 290 295 <210> 627 <211> 301 <212> PRT <213> Homo sapiens <400> 627 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 145 150 155 160 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 165 170 175 Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 180 185 190 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 195 200 205 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 210 215 220 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr 225 230 235 240 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 245 250 255 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 260 265 270 Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 275 280 285 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 290 295 300 <210> 628 <211> 296 <212> PRT <213> Homo sapiens <400> 628 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 145 150 155 160 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 165 170 175 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 180 185 190 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe 195 200 205 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 210 215 220 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 225 230 235 240 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 245 250 255 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 260 265 270 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 275 280 285 Phe Gln Pro Pro Pro Ser Cys Leu 290 295 <210> 629 <211> 301 <212> PRT <213> Homo sapiens <400> 629 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 145 150 155 160 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 165 170 175 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 180 185 190 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr 195 200 205 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 210 215 220 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 225 230 235 240 Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 245 250 255 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 260 265 270 Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe 275 280 285 Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 290 295 300 <210> 630 <211> 296 <212> PRT <213> Homo sapiens <400> 630 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Ser Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 145 150 155 160 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 165 170 175 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190 Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro 195 200 205 Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 210 215 220 Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu 225 230 235 240 Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu 245 250 255 Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg 260 265 270 Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro 275 280 285 Pro Ser Cys Leu Arg Phe Val Gln 290 295 <210> 631 <211> 301 <212> PRT <213> Homo sapiens <400> 631 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 145 150 155 160 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 165 170 175 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser 195 200 205 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 210 215 220 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 225 230 235 240 Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 245 250 255 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 260 265 270 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 275 280 285 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln 290 295 300 <210> 632 <211> 292 <212> PRT <213> Homo sapiens <400> 632 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 145 150 155 160 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 165 170 175 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 180 185 190 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 195 200 205 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 210 215 220 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 225 230 235 240 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser 245 250 255 Thr Leu Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe Gln His 260 265 270 Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp 275 280 285 Tyr Leu Leu Gln 290 <210> 633 <211> 293 <212> PRT <213> Homo sapiens <400> 633 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 145 150 155 160 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 165 170 175 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 180 185 190 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 195 200 205 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 210 215 220 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 225 230 235 240 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser 245 250 255 Thr Leu Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln 260 265 270 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 275 280 285 Asp Tyr Leu Leu Gln 290 <210> 634 <211> 299 <212> PRT <213> Homo sapiens <400> 634 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 145 150 155 160 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 165 170 175 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 180 185 190 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 195 200 205 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 210 215 220 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 225 230 235 240 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser 245 250 255 Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr 260 265 270 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 275 280 285 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 290 295 <210> 635 <211> 307 <212> PRT <213> Homo sapiens <400> 635 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 145 150 155 160 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 165 170 175 Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 180 185 190 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 195 200 205 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 210 215 220 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 225 230 235 240 Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 245 250 255 Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu 260 265 270 Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu 275 280 285 Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg 290 295 300 Leu Lys Thr 305 <210> 636 <211> 292 <212> PRT <213> Homo sapiens <400> 636 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 180 185 190 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 195 200 205 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 210 215 220 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 225 230 235 240 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255 Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 260 265 270 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 275 280 285 Pro Val Thr Val 290 <210> 637 <211> 293 <212> PRT <213> Homo sapiens <400> 637 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 180 185 190 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 195 200 205 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 210 215 220 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 225 230 235 240 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255 Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 260 265 270 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 275 280 285 Tyr Pro Val Thr Val 290 <210> 638 <211> 299 <212> PRT <213> Homo sapiens <400> 638 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 180 185 190 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 195 200 205 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 210 215 220 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 225 230 235 240 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255 Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln 260 265 270 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 275 280 285 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val 290 295 <210> 639 <211> 307 <212> PRT <213> Homo sapiens <400> 639 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 180 185 190 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 195 200 205 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 210 215 220 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 225 230 235 240 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 260 265 270 Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 275 280 285 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 290 295 300 Val Thr Val 305 <210> 640 <211> 292 <212> PRT <213> Homo sapiens <400> 640 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 145 150 155 160 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 165 170 175 Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 180 185 190 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 195 200 205 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 210 215 220 Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro 225 230 235 240 Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 245 250 255 Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu 260 265 270 Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu 275 280 285 Arg Leu Lys Thr 290 <210> 641 <211> 293 <212> PRT <213> Homo sapiens <400> 641 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 145 150 155 160 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 165 170 175 Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 180 185 190 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 195 200 205 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 210 215 220 Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser 225 230 235 240 Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr 245 250 255 Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 260 265 270 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 275 280 285 Glu Arg Leu Lys Thr 290 <210> 642 <211> 299 <212> PRT <213> Homo sapiens <400> 642 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 145 150 155 160 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 165 170 175 Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 180 185 190 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 195 200 205 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 210 215 220 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp 225 230 235 240 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 245 250 255 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 260 265 270 Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 275 280 285 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 290 295 <210> 643 <211> 307 <212> PRT <213> Homo sapiens <400> 643 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 145 150 155 160 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 165 170 175 Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 180 185 190 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 195 200 205 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 210 215 220 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 225 230 235 240 Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 245 250 255 Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu 260 265 270 Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu 275 280 285 Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg 290 295 300 Leu Lys Thr 305 <210> 644 <211> 292 <212> PRT <213> Homo sapiens <400> 644 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 145 150 155 160 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 165 170 175 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 180 185 190 Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro 195 200 205 Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 210 215 220 Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu 225 230 235 240 Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu 245 250 255 Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg 260 265 270 Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro 275 280 285 Pro Ser Cys Leu 290 <210> 645 <211> 293 <212> PRT <213> Homo sapiens <400> 645 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 145 150 155 160 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 165 170 175 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 180 185 190 Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser 195 200 205 Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr 210 215 220 Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 225 230 235 240 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 245 250 255 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 260 265 270 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 275 280 285 Pro Pro Ser Cys Leu 290 <210> 646 <211> 299 <212> PRT <213> Homo sapiens <400> 646 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 145 150 155 160 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 165 170 175 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 180 185 190 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp 195 200 205 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 210 215 220 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 225 230 235 240 Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 245 250 255 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 260 265 270 Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr 275 280 285 Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 290 295 <210> 647 <211> 307 <212> PRT <213> Homo sapiens <400> 647 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 145 150 155 160 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 165 170 175 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 180 185 190 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 195 200 205 Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 210 215 220 Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu 225 230 235 240 Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu 245 250 255 Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg 260 265 270 Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 275 280 285 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 290 295 300 Ser Cys Leu 305 <210> 648 <211> 292 <212> PRT <213> Homo sapiens <400> 648 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Ser Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 145 150 155 160 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 165 170 175 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190 Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 195 200 205 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 210 215 220 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 225 230 235 240 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 245 250 255 Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 260 265 270 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 275 280 285 Arg Phe Val Gln 290 <210> 649 <211> 293 <212> PRT <213> Homo sapiens <400> 649 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Ser Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 145 150 155 160 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 165 170 175 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190 Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 195 200 205 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 210 215 220 Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly 225 230 235 240 Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys 245 250 255 Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr 260 265 270 Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys 275 280 285 Leu Arg Phe Val Gln 290 <210> 650 <211> 299 <212> PRT <213> Homo sapiens <400> 650 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Ser Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 145 150 155 160 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 165 170 175 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190 Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln 195 200 205 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 210 215 220 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 225 230 235 240 Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 245 250 255 Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 260 265 270 Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 275 280 285 Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln 290 295 <210> 651 <211> 307 <212> PRT <213> Homo sapiens <400> 651 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 145 150 155 160 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 165 170 175 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 195 200 205 Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 210 215 220 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 225 230 235 240 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 245 250 255 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 260 265 270 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 275 280 285 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 290 295 300 Phe Val Gln 305 <210> 652 <211> 749 <212> PRT <213> Homo sapiens <400> 652 Gly Ser Thr Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu 1 5 10 15 Val Arg Pro Ala Met Ser Thr Asn Gln Asp Leu Pro Val Ile Lys Cys 20 25 30 Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly Lys Ser Ser 35 40 45 Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly Cys Ala Leu 50 55 60 Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala Val Glu Val 65 70 75 80 Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp Ala Pro Gly 85 90 95 Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu Asn Cys Gln 100 105 110 Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met Val Ile Leu 115 120 125 Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe Ile Gln Ser 130 135 140 Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile Arg Asn Thr 145 150 155 160 Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met Glu Asn Gln 165 170 175 Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro Ile Val Glu 180 185 190 Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu Glu Ser Pro 195 200 205 Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu Phe Gly Met 210 215 220 Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu Cys Thr Arg 225 230 235 240 Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr Leu Pro Gln 245 250 255 Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys Lys Ala Val 260 265 270 His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu Asn Lys Ala 275 280 285 Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser Thr Asn Arg 290 295 300 Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val Ala Arg Asn 305 310 315 320 Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro Ser Gln Ser 325 330 335 Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala Thr Asn Ser 340 345 350 Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys Phe Ser Val 355 360 365 Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr Phe Ser Arg 370 375 380 Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly Tyr Ser Ile 385 390 395 400 Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr Ile Phe His 405 410 415 Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr Leu Asn Ile 420 425 430 Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser Gln Ala Ser 435 440 445 Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp Lys Lys Cys 450 455 460 Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu Gly Val Trp 465 470 475 480 Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val Ser Ser Ser 485 490 495 Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val Lys Cys Cys 500 505 510 Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu Leu Asn Ser 515 520 525 Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Glu Phe Ile Ile Leu Gly 530 535 540 Leu Phe Gly Leu Leu Leu Leu Leu Thr Cys Leu Cys Gly Thr Ala Trp 545 550 555 560 Leu Cys Cys Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro 565 570 575 Asp Pro Ala His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu 580 585 590 Glu Asp Ala Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys 595 600 605 Leu Thr Val Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser 610 615 620 His Asn Ser Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln Thr Tyr 625 630 635 640 Val Leu Gln Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln Ser Gln 645 650 655 Ser Gly Thr Ser Asp Gln Val Leu Tyr Gly Gln Leu Leu Gly Ser Pro 660 665 670 Thr Ser Pro Gly Pro Gly His Tyr Leu Arg Cys Asp Ser Thr Gln Pro 675 680 685 Leu Leu Ala Gly Leu Thr Pro Ser Pro Lys Ser Tyr Glu Asn Leu Trp 690 695 700 Phe Gln Ala Ser Pro Leu Gly Thr Leu Val Thr Pro Ala Pro Ser Gln 705 710 715 720 Glu Asp Asp Cys Val Phe Gly Pro Leu Leu Asn Phe Pro Leu Leu Gln 725 730 735 Gly Ile Arg Val His Gly Met Glu Ala Leu Gly Ser Phe 740 745 <210> 653 <211> 349 <212> PRT <213> Homo sapiens <400> 653 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 210 215 220 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 225 230 235 240 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 245 250 255 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 260 265 270 Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 275 280 285 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 290 295 300 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 305 310 315 320 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 325 330 335 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 340 345 <210> 654 <211> 314 <212> PRT <213> Homo sapiens <400> 654 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140 Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn 145 150 155 160 Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr 165 170 175 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 180 185 190 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 195 200 205 Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 210 215 220 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 225 230 235 240 Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe 245 250 255 Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val 260 265 270 Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val 275 280 285 Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu 290 295 300 Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 305 310 <210> 655 <211> 349 <212> PRT <213> Homo sapiens <400> 655 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140 Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn 145 150 155 160 Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr 165 170 175 Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys 180 185 190 Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu 195 200 205 Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu 210 215 220 Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro 225 230 235 240 Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly 245 250 255 Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro 260 265 270 Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe 275 280 285 Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala 290 295 300 Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln 305 310 315 320 Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu 325 330 335 Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 340 345 <210> 656 <211> 523 <212> PRT <213> Homo sapiens <400> 656 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 210 215 220 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 225 230 235 240 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 245 250 255 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 260 265 270 Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 275 280 285 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 290 295 300 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 305 310 315 320 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 325 330 335 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Tyr Val Glu 340 345 350 Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile 355 360 365 Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala 370 375 380 Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 385 390 395 400 Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 405 410 415 Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 420 425 430 Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 435 440 445 Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 450 455 460 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 465 470 475 480 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 485 490 495 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 500 505 510 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 515 520 <210> 657 <211> 460 <212> PRT <213> Homo sapiens <400> 657 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 145 150 155 160 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 165 170 175 Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly 180 185 190 Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys 195 200 205 Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr 210 215 220 Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys 225 230 235 240 Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser 245 250 255 Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser 260 265 270 Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Tyr Val 275 280 285 Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr 290 295 300 Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met 305 310 315 320 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 325 330 335 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 340 345 350 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 355 360 365 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 370 375 380 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 385 390 395 400 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 405 410 415 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 420 425 430 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 435 440 445 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 450 455 460 <210> 658 <211> 523 <212> PRT <213> Homo sapiens <400> 658 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140 Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn 145 150 155 160 Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr 165 170 175 Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser 180 185 190 Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu 195 200 205 Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu 210 215 220 Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro 225 230 235 240 Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly 245 250 255 Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro 260 265 270 Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe 275 280 285 Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala 290 295 300 Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln 305 310 315 320 Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu 325 330 335 Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr Val Glu 340 345 350 Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile 355 360 365 Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala 370 375 380 Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 385 390 395 400 Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 405 410 415 Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 420 425 430 Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 435 440 445 Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 450 455 460 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 465 470 475 480 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 485 490 495 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 500 505 510 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 515 520 <210> 659 <211> 334 <212> PRT <213> Homo sapiens <400> 659 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140 Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala 145 150 155 160 Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 165 170 175 Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 180 185 190 Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 195 200 205 Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 210 215 220 Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 225 230 235 240 Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 245 250 255 Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp 260 265 270 Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro 275 280 285 Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 290 295 300 Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 305 310 315 320 Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 325 330 <210> 660 <211> 296 <212> PRT <213> Homo sapiens <400> 660 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 145 150 155 160 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 165 170 175 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 180 185 190 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 195 200 205 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 210 215 220 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 225 230 235 240 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser 245 250 255 Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys 260 265 270 Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 275 280 285 Glu Leu Ser Asp Tyr Leu Leu Gln 290 295 <210> 661 <211> 301 <212> PRT <213> Homo sapiens <400> 661 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 145 150 155 160 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 165 170 175 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 180 185 190 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 195 200 205 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 210 215 220 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 225 230 235 240 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser 245 250 255 Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 260 265 270 Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 275 280 285 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 290 295 300 <210> 662 <211> 296 <212> PRT <213> Homo sapiens <400> 662 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 180 185 190 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 195 200 205 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 210 215 220 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 225 230 235 240 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255 Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro 260 265 270 Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 275 280 285 Leu Gln Asp Tyr Pro Val Thr Val 290 295 <210> 663 <211> 301 <212> PRT <213> Homo sapiens <400> 663 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 180 185 190 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 195 200 205 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 210 215 220 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 225 230 235 240 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser 260 265 270 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 275 280 285 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val 290 295 300 <210> 664 <211> 296 <212> PRT <213> Homo sapiens <400> 664 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 145 150 155 160 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 165 170 175 Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 180 185 190 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 195 200 205 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 210 215 220 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe 225 230 235 240 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 245 250 255 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 260 265 270 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 275 280 285 Arg Trp Met Glu Arg Leu Lys Thr 290 295 <210> 665 <211> 301 <212> PRT <213> Homo sapiens <400> 665 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 145 150 155 160 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 165 170 175 Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 180 185 190 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 195 200 205 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 210 215 220 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr 225 230 235 240 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 245 250 255 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 260 265 270 Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 275 280 285 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 290 295 300 <210> 666 <211> 296 <212> PRT <213> Homo sapiens <400> 666 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 145 150 155 160 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 165 170 175 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 180 185 190 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe 195 200 205 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 210 215 220 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 225 230 235 240 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 245 250 255 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 260 265 270 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 275 280 285 Phe Gln Pro Pro Pro Ser Cys Leu 290 295 <210> 667 <211> 301 <212> PRT <213> Homo sapiens <400> 667 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 145 150 155 160 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 165 170 175 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 180 185 190 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr 195 200 205 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 210 215 220 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 225 230 235 240 Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 245 250 255 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 260 265 270 Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe 275 280 285 Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 290 295 300 <210> 668 <211> 296 <212> PRT <213> Homo sapiens <400> 668 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Ser Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 145 150 155 160 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 165 170 175 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190 Gly Gly Gly Ser Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro 195 200 205 Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu 210 215 220 Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu 225 230 235 240 Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu 245 250 255 Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg 260 265 270 Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro 275 280 285 Pro Ser Cys Leu Arg Phe Val Gln 290 295 <210> 669 <211> 301 <212> PRT <213> Homo sapiens <400> 669 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 145 150 155 160 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 165 170 175 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser 195 200 205 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 210 215 220 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 225 230 235 240 Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 245 250 255 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 260 265 270 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 275 280 285 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln 290 295 300 <210> 670 <211> 307 <212> PRT <213> Homo sapiens <400> 670 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 145 150 155 160 Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 165 170 175 Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 180 185 190 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 195 200 205 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 210 215 220 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 225 230 235 240 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 245 250 255 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 260 265 270 Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 275 280 285 Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 290 295 300 Thr Val Ala 305 <210> 671 <211> 307 <212> PRT <213> Homo sapiens <400> 671 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 145 150 155 160 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 165 170 175 Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe 180 185 190 Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val 195 200 205 Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val 210 215 220 Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu 225 230 235 240 Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 245 250 255 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr 260 265 270 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 275 280 285 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 290 295 300 Val Ala Ser 305 <210> 672 <211> 307 <212> PRT <213> Homo sapiens <400> 672 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu 145 150 155 160 Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser 165 170 175 Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val 180 185 190 Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln 195 200 205 Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala 210 215 220 Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu 225 230 235 240 Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly 245 250 255 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln 260 265 270 Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys 275 280 285 Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val 290 295 300 Ala Ser Asn 305 <210> 673 <211> 307 <212> PRT <213> Homo sapiens <400> 673 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 145 150 155 160 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 165 170 175 Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr 180 185 190 Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr 195 200 205 Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu 210 215 220 Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln 225 230 235 240 Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser 245 250 255 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp 260 265 270 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 275 280 285 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 290 295 300 Ser Asn Leu 305 <210> 674 <211> 305 <212> PRT <213> Homo sapiens <400> 674 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg 35 40 45 Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg 50 55 60 Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His 65 70 75 80 Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu 85 90 95 Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr Val 100 105 110 Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr 115 120 125 Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met 130 135 140 Ala Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 145 150 155 160 Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 165 170 175 Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 180 185 190 Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg 195 200 205 Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile 210 215 220 Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp 225 230 235 240 Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 245 250 255 Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln 260 265 270 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 275 280 285 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 290 295 300 Asp 305 <210> 675 <211> 307 <212> PRT <213> Homo sapiens <400> 675 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 145 150 155 160 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 165 170 175 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 180 185 190 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 195 200 205 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 210 215 220 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 225 230 235 240 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 245 250 255 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 260 265 270 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 275 280 285 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 290 295 300 Gln Asp Glu 305 <210> 676 <211> 307 <212> PRT <213> Homo sapiens <400> 676 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 145 150 155 160 Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 165 170 175 Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 180 185 190 Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg 195 200 205 Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile 210 215 220 Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp 225 230 235 240 Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 245 250 255 Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln 260 265 270 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 275 280 285 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 290 295 300 Asp Glu Glu 305 <210> 677 <211> 307 <212> PRT <213> Homo sapiens <400> 677 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp 145 150 155 160 Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala 165 170 175 Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 180 185 190 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 195 200 205 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 210 215 220 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 225 230 235 240 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 245 250 255 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 260 265 270 Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Ser Ala 275 280 285 Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val 290 295 300 Thr Val Ala 305 <210> 678 <211> 307 <212> PRT <213> Homo sapiens <400> 678 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 145 150 155 160 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 165 170 175 Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr 180 185 190 Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr 195 200 205 Asn Ile Ser Arg Leu Leu Arg Glu Thr Ser Glu Gln Pro Val Ala Leu 210 215 220 Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln 225 230 235 240 Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser 245 250 255 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp 260 265 270 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 275 280 285 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 290 295 300 Ser Asn Leu 305 <210> 679 <211> 307 <212> PRT <213> Homo sapiens <400> 679 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 145 150 155 160 Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 165 170 175 Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 180 185 190 Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg 195 200 205 Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile 210 215 220 Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Arg Pro Asp 225 230 235 240 Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 245 250 255 Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln 260 265 270 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 275 280 285 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 290 295 300 Asp Glu Glu 305 <210> 680 <211> 302 <212> PRT <213> Homo sapiens <400> 680 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Tyr Val Glu Gly 145 150 155 160 Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn 165 170 175 Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn 180 185 190 Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro 195 200 205 Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile 210 215 220 Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg 225 230 235 240 Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg 245 250 255 Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His 260 265 270 Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu 275 280 285 Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 290 295 300 <210> 681 <211> 296 <212> PRT <213> Homo sapiens <400> 681 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Arg Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr 100 105 110 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 115 120 125 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 130 135 140 Val Ala Ser Asn Leu Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly 145 150 155 160 Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys 165 170 175 Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys Ser Ile Met Ile Asp 180 185 190 Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro 195 200 205 Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu 210 215 220 Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu 225 230 235 240 Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu 245 250 255 Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala 260 265 270 Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr 275 280 285 Leu Glu Gln Ala Gln Glu Gln Gln 290 295 <210> 682 <211> 301 <212> PRT <213> Homo sapiens <400> 682 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 115 120 125 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 130 135 140 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190 Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn 195 200 205 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu 210 215 220 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240 Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn 245 250 255 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr 275 280 285 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 290 295 300 <210> 683 <211> 307 <212> PRT <213> Homo sapiens <400> 683 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His 195 200 205 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240 Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile 245 250 255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 275 280 285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 290 295 300 Glu Gln Gln 305 <210> 684 <211> 301 <212> PRT <213> Homo sapiens <400> 684 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Leu Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 115 120 125 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 130 135 140 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190 Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn 195 200 205 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu 210 215 220 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240 Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn 245 250 255 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr 275 280 285 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 290 295 300 <210> 685 <211> 307 <212> PRT <213> Homo sapiens <400> 685 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Gly Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His 195 200 205 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240 Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile 245 250 255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 275 280 285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 290 295 300 Glu Gln Gln 305 <210> 686 <211> 302 <212> PRT <213> Homo sapiens <400> 686 Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu 1 5 10 15 Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu 20 25 30 Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg 35 40 45 Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro 50 55 60 Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln 65 70 75 80 Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln 85 90 95 Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr 100 105 110 Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 115 120 125 Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala 130 135 140 Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Tyr Val Glu Gly 145 150 155 160 Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn 165 170 175 Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn 180 185 190 Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro 195 200 205 Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile 210 215 220 Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg 225 230 235 240 Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg 245 250 255 Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His 260 265 270 Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu 275 280 285 Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 290 295 300 <210> 687 <211> 301 <212> PRT <213> Homo sapiens <400> 687 Ala Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 1 5 10 15 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 20 25 30 Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe 35 40 45 Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val 50 55 60 Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val 65 70 75 80 Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu 85 90 95 Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln 115 120 125 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 130 135 140 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190 Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn 195 200 205 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu 210 215 220 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240 Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn 245 250 255 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr 275 280 285 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 290 295 300 <210> 688 <211> 301 <212> PRT <213> Homo sapiens <400> 688 Ala Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr 1 5 10 15 Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys 20 25 30 Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser 35 40 45 Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser 50 55 60 Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly 65 70 75 80 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp 85 90 95 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 100 105 110 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 115 120 125 Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 130 135 140 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190 Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn 195 200 205 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu 210 215 220 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240 Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn 245 250 255 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr 275 280 285 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 290 295 300 <210> 689 <211> 301 <212> PRT <213> Homo sapiens <400> 689 Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 1 5 10 15 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 35 40 45 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 50 55 60 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 65 70 75 80 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe 85 90 95 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 100 105 110 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 130 135 140 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190 Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn 195 200 205 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu 210 215 220 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240 Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn 245 250 255 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr 275 280 285 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 290 295 300 <210> 690 <211> 301 <212> PRT <213> Homo sapiens <400> 690 Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 1 5 10 15 Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 20 25 30 Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 35 40 45 Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 50 55 60 Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 65 70 75 80 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 85 90 95 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 100 105 110 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 115 120 125 Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 130 135 140 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190 Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn 195 200 205 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu 210 215 220 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240 Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn 245 250 255 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr 275 280 285 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 290 295 300 <210> 691 <211> 301 <212> PRT <213> Homo sapiens <400> 691 Ala Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val 1 5 10 15 Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu 20 25 30 Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 35 40 45 Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln 50 55 60 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 65 70 75 80 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 85 90 95 Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 100 105 110 Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 115 120 125 Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 130 135 140 Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190 Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn 195 200 205 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu 210 215 220 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240 Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn 245 250 255 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr 275 280 285 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 290 295 300 <210> 692 <211> 301 <212> PRT <213> Homo sapiens <400> 692 Ala Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser 1 5 10 15 Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser 20 25 30 Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly 35 40 45 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp 50 55 60 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 65 70 75 80 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 85 90 95 Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 100 105 110 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 115 120 125 Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr 130 135 140 Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Phe Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190 Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn 195 200 205 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu 210 215 220 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240 Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn 245 250 255 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr 275 280 285 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 290 295 300 <210> 693 <211> 307 <212> PRT <213> Homo sapiens <400> 693 Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu 1 5 10 15 Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser 20 25 30 Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val 35 40 45 Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln 50 55 60 Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala 65 70 75 80 Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu 85 90 95 Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln 115 120 125 Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys 130 135 140 Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val 145 150 155 160 Ala Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His 195 200 205 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240 Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile 245 250 255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 275 280 285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 290 295 300 Glu Gln Gln 305 <210> 694 <211> 307 <212> PRT <213> Homo sapiens <400> 694 Ala Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 1 5 10 15 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 20 25 30 Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr 35 40 45 Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr 50 55 60 Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu 65 70 75 80 Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln 85 90 95 Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser 100 105 110 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp 115 120 125 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 130 135 140 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 145 150 155 160 Ser Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His 195 200 205 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240 Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile 245 250 255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 275 280 285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 290 295 300 Glu Gln Gln 305 <210> 695 <211> 307 <212> PRT <213> Homo sapiens <400> 695 Ala Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 1 5 10 15 Ala Gln Arg Leu Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 20 25 30 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 35 40 45 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 50 55 60 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 65 70 75 80 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 85 90 95 Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 100 105 110 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys 115 120 125 Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 130 135 140 Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser 145 150 155 160 Asn Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His 195 200 205 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240 Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile 245 250 255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 275 280 285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 290 295 300 Glu Gln Gln 305 <210> 696 <211> 307 <212> PRT <213> Homo sapiens <400> 696 Ala Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 1 5 10 15 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 20 25 30 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 35 40 45 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 50 55 60 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 65 70 75 80 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 85 90 95 Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser 115 120 125 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 130 135 140 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 145 150 155 160 Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His 195 200 205 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240 Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile 245 250 255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 275 280 285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 290 295 300 Glu Gln Gln 305 <210> 697 <211> 307 <212> PRT <213> Homo sapiens <400> 697 Ala Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 1 5 10 15 Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 20 25 30 Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 35 40 45 Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg 50 55 60 Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile 65 70 75 80 Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp 85 90 95 Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 100 105 110 Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln 115 120 125 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 130 135 140 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 145 150 155 160 Asp Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His 195 200 205 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240 Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile 245 250 255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 275 280 285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 290 295 300 Glu Gln Gln 305 <210> 698 <211> 307 <212> PRT <213> Homo sapiens <400> 698 Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 1 5 10 15 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 20 25 30 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 35 40 45 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 50 55 60 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 65 70 75 80 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser 85 90 95 Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser 115 120 125 Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr 130 135 140 Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 145 150 155 160 Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His 195 200 205 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240 Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile 245 250 255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 275 280 285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 290 295 300 Glu Gln Gln 305 <210> 699 <211> 307 <212> PRT <213> Homo sapiens <400> 699 Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 1 5 10 15 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 20 25 30 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 35 40 45 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 50 55 60 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 65 70 75 80 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser 85 90 95 Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser 115 120 125 Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr 130 135 140 Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 145 150 155 160 Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His 195 200 205 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240 Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile 245 250 255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 275 280 285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 290 295 300 Glu Gln Gln 305 <210> 700 <211> 307 <212> PRT <213> Homo sapiens <400> 700 Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 1 5 10 15 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 20 25 30 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 35 40 45 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 50 55 60 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 65 70 75 80 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Arg Pro Asp Ser Ser 85 90 95 Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser 115 120 125 Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr 130 135 140 Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 145 150 155 160 Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His 195 200 205 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240 Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile 245 250 255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 275 280 285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 290 295 300 Glu Gln Gln 305 <210> 701 <211> 301 <212> PRT <213> Homo sapiens <400> 701 Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 1 5 10 15 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 35 40 45 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 50 55 60 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 65 70 75 80 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe 85 90 95 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 100 105 110 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 130 135 140 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190 Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn 195 200 205 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu 210 215 220 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240 Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn 245 250 255 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr 275 280 285 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 290 295 300 <210> 702 <211> 315 <212> PRT <213> Homo sapiens <400> 702 Ala Gln Asp Asp Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 1 5 10 15 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 20 25 30 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 35 40 45 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 50 55 60 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 65 70 75 80 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 85 90 95 Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 115 120 125 Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 130 135 140 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 145 150 155 160 Tyr Pro Val Thr Val Ala Ser Asn Leu Tyr Val Glu Gly Gly Gly Gly 165 170 175 Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro 180 185 190 Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys Ser Ile 195 200 205 Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn Pro Leu 210 215 220 Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu Met Glu 225 230 235 240 Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys 245 250 255 His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn Leu Gln 260 265 270 Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro Ile Ile 275 280 285 Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr 290 295 300 Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 305 310 315 <210> 703 <211> 301 <212> PRT <213> Homo sapiens <400> 703 Ala Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 1 5 10 15 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 20 25 30 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 35 40 45 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 50 55 60 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 65 70 75 80 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 85 90 95 Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly 100 105 110 Ala Thr Ala Pro Thr Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 115 120 125 Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu 130 135 140 Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190 Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn 195 200 205 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu 210 215 220 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240 Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn 245 250 255 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr 275 280 285 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 290 295 300 <210> 704 <211> 307 <212> PRT <213> Homo sapiens <400> 704 Ala Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 1 5 10 15 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 20 25 30 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 35 40 45 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 50 55 60 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 65 70 75 80 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 85 90 95 Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly 100 105 110 Ala Thr Ala Pro Thr Ala Gly Gln Pro Pro Leu Thr Gln Asp Cys Ser 115 120 125 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 130 135 140 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 145 150 155 160 Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His 195 200 205 Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220 Glu Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240 Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile 245 250 255 Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270 Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu 275 280 285 Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln 290 295 300 Glu Gln Gln 305 <210> 705 <211> 370 <212> PRT <213> Homo sapiens <400> 705 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 225 230 235 240 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 245 250 255 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 260 265 270 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 275 280 285 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 290 295 300 Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 305 310 315 320 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser 325 330 335 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 340 345 350 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 355 360 365 Leu Gln 370 <210> 706 <211> 370 <212> PRT <213> Homo sapiens <400> 706 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu 210 215 220 Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser 225 230 235 240 Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val 245 250 255 Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln 260 265 270 Ile Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala 275 280 285 Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu 290 295 300 Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly 305 310 315 320 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln 325 330 335 Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys 340 345 350 Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val 355 360 365 Ala Ser 370 <210> 707 <211> 370 <212> PRT <213> Homo sapiens <400> 707 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg 210 215 220 Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile 225 230 235 240 Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp 245 250 255 Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 260 265 270 Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln 275 280 285 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 290 295 300 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 305 310 315 320 Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 325 330 335 Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 340 345 350 Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 355 360 365 Gln Pro 370 <210> 708 <211> 370 <212> PRT <213> Homo sapiens <400> 708 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 210 215 220 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 225 230 235 240 Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr 245 250 255 Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr 260 265 270 Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu 275 280 285 Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln 290 295 300 Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser 305 310 315 320 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp 325 330 335 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 340 345 350 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 355 360 365 Ser Asn 370 <210> 709 <211> 370 <212> PRT <213> Homo sapiens <400> 709 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 210 215 220 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 225 230 235 240 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 245 250 255 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 260 265 270 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 275 280 285 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 290 295 300 Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 305 310 315 320 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys 325 330 335 Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 340 345 350 Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser 355 360 365 Asn Leu 370 <210> 710 <211> 370 <212> PRT <213> Homo sapiens <400> 710 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 210 215 220 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 225 230 235 240 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 245 250 255 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 260 265 270 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 275 280 285 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 290 295 300 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 305 310 315 320 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 325 330 335 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 340 345 350 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 355 360 365 Gln Asp 370 <210> 711 <211> 370 <212> PRT <213> Homo sapiens <400> 711 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 210 215 220 Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 225 230 235 240 Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 245 250 255 Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg 260 265 270 Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile 275 280 285 Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp 290 295 300 Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 305 310 315 320 Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln 325 330 335 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 340 345 350 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 355 360 365 Asp Glu 370 <210> 712 <211> 370 <212> PRT <213> Homo sapiens <400> 712 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp 210 215 220 Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu 225 230 235 240 Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln 245 250 255 Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 260 265 270 Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 275 280 285 Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 290 295 300 Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 305 310 315 320 Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His 325 330 335 Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp 340 345 350 Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp 355 360 365 Glu Glu 370 <210> 713 <211> 364 <212> PRT <213> Homo sapiens <400> 713 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 225 230 235 240 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 245 250 255 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 260 265 270 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 275 280 285 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 290 295 300 Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly 305 310 315 320 Ala Thr Ala Pro Thr Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 325 330 335 Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu 340 345 350 Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 355 360 <210> 714 <211> 378 <212> PRT <213> Homo sapiens <400> 714 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 225 230 235 240 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 245 250 255 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 260 265 270 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 275 280 285 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 290 295 300 Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 305 310 315 320 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 325 330 335 Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 340 345 350 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 355 360 365 Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 370 375 <210> 715 <211> 370 <212> PRT <213> Homo sapiens <400> 715 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 225 230 235 240 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 245 250 255 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 260 265 270 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 275 280 285 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 290 295 300 Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly 305 310 315 320 Ala Thr Ala Pro Thr Ala Gly Gln Pro Pro Leu Thr Gln Asp Cys Ser 325 330 335 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 340 345 350 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 355 360 365 Leu Gln 370 <210> 716 <211> 155 <212> PRT <213> Homo sapiens <400> 716 Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu 1 5 10 15 Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg 20 25 30 Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 35 40 45 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 50 55 60 Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 65 70 75 80 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 85 90 95 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 100 105 110 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr 115 120 125 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 130 135 140 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 145 150 155 <210> 717 <211> 155 <212> PRT <213> Homo sapiens <400> 717 Ala Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 1 5 10 15 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 20 25 30 Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe 35 40 45 Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val 50 55 60 Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val 65 70 75 80 Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu 85 90 95 Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln 115 120 125 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 130 135 140 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val 145 150 155 <210> 718 <211> 155 <212> PRT <213> Homo sapiens <400> 718 Ala Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr 1 5 10 15 Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys 20 25 30 Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser 35 40 45 Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser 50 55 60 Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly 65 70 75 80 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp 85 90 95 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 100 105 110 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 115 120 125 Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 130 135 140 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 145 150 155 <210> 719 <211> 155 <212> PRT <213> Homo sapiens <400> 719 Ala Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr 1 5 10 15 Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys 20 25 30 Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser 35 40 45 Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser 50 55 60 Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly 65 70 75 80 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp 85 90 95 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 100 105 110 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 115 120 125 Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 130 135 140 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 145 150 155 <210> 720 <211> 155 <212> PRT <213> Homo sapiens <400> 720 Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 1 5 10 15 Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 20 25 30 Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 35 40 45 Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 50 55 60 Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 65 70 75 80 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 85 90 95 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 100 105 110 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 115 120 125 Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 130 135 140 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 145 150 155 <210> 721 <211> 155 <212> PRT <213> Homo sapiens <400> 721 Ala Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser 1 5 10 15 Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser 20 25 30 Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly 35 40 45 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp 50 55 60 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 65 70 75 80 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 85 90 95 Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 100 105 110 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 115 120 125 Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr 130 135 140 Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 145 150 155 <210> 722 <211> 155 <212> PRT <213> Homo sapiens <400> 722 Ala Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val 1 5 10 15 Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu 20 25 30 Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 35 40 45 Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln 50 55 60 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 65 70 75 80 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 85 90 95 Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 100 105 110 Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 115 120 125 Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 130 135 140 Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln 145 150 155 <210> 723 <211> 370 <212> PRT <213> Homo sapiens <400> 723 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 724 <211> 370 <212> PRT <213> Homo sapiens <400> 724 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 725 <211> 354 <212> PRT <213> Homo sapiens <400> 725 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly Ala 100 105 110 Thr Ala Pro Thr Ala Gly Gln Pro Pro Leu Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly 165 170 175 Ser Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 180 185 190 Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 195 200 205 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 210 215 220 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 225 230 235 240 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 245 250 255 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 260 265 270 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 275 280 285 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 290 295 300 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 305 310 315 320 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 325 330 335 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 340 345 350 Gln Pro <210> 726 <211> 363 <212> PRT <213> Homo sapiens <400> 726 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 115 120 125 Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 130 135 140 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 145 150 155 160 Pro Val Thr Val Ala Ser Asn Leu Gln Tyr Val Glu Gly Gly Gly Gly 165 170 175 Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Thr Pro Leu 180 185 190 Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu 195 200 205 Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu 210 215 220 Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 225 230 235 240 His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln 245 250 255 Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 260 265 270 Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 275 280 285 Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 290 295 300 Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 305 310 315 320 Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg 325 330 335 Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val 340 345 350 Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 355 360 <210> 727 <211> 348 <212> PRT <213> Homo sapiens <400> 727 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly Ala 100 105 110 Thr Ala Pro Thr Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 115 120 125 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 130 135 140 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Tyr Val Glu Gly Gly Gly 145 150 155 160 Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Thr Pro 165 170 175 Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu 180 185 190 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 195 200 205 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 210 215 220 Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 225 230 235 240 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 245 250 255 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 260 265 270 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 275 280 285 Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 290 295 300 Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 305 310 315 320 Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 325 330 335 Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 340 345 <210> 728 <211> 359 <212> PRT <213> Homo sapiens <400> 728 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Arg Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr 100 105 110 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 115 120 125 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 130 135 140 Val Ala Ser Asn Leu Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly 145 150 155 160 Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys 165 170 175 Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser 180 185 190 Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys 195 200 205 Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr 210 215 220 Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly 225 230 235 240 Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu 245 250 255 Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly 260 265 270 Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu 275 280 285 Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln 290 295 300 Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly 305 310 315 320 Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val 325 330 335 Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val 340 345 350 Leu Arg His Leu Ala Gln Pro 355 <210> 729 <211> 364 <212> PRT <213> Homo sapiens <400> 729 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 115 120 125 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 130 135 140 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190 Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 195 200 205 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 210 215 220 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240 Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 260 265 270 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 275 280 285 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 290 295 300 Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320 Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 325 330 335 Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 340 345 350 Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 355 360 <210> 730 <211> 370 <212> PRT <213> Homo sapiens <400> 730 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Val Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 731 <211> 364 <212> PRT <213> Homo sapiens <400> 731 Ala Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 1 5 10 15 Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 20 25 30 Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 35 40 45 Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 50 55 60 Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 65 70 75 80 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 85 90 95 Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 100 105 110 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 115 120 125 Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 130 135 140 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190 Leu Gly Pro Ala Ser Ser Val Pro Gln Ser Phe Leu Leu Lys Cys Leu 195 200 205 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 210 215 220 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240 Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 260 265 270 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 275 280 285 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 290 295 300 Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320 Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 325 330 335 Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 340 345 350 Val Ser Tyr Arg Val Ile Arg His Leu Ala Gln Pro 355 360 <210> 732 <211> 370 <212> PRT <213> Homo sapiens <400> 732 Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu 1 5 10 15 Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser 20 25 30 Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val 35 40 45 Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln 50 55 60 Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala 65 70 75 80 Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu 85 90 95 Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln 115 120 125 Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys 130 135 140 Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val 145 150 155 160 Ala Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser His Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 733 <211> 370 <212> PRT <213> Homo sapiens <400> 733 Ala Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 1 5 10 15 Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 20 25 30 Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr 35 40 45 Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr 50 55 60 Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu 65 70 75 80 Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln 85 90 95 Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser 100 105 110 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp 115 120 125 Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile 130 135 140 Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala 145 150 155 160 Ser Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Ile Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 734 <211> 370 <212> PRT <213> Homo sapiens <400> 734 Ala Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 1 5 10 15 Ala Gln Arg Leu Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 20 25 30 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 35 40 45 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 50 55 60 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 65 70 75 80 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 85 90 95 Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 100 105 110 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys 115 120 125 Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 130 135 140 Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser 145 150 155 160 Asn Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 735 <211> 370 <212> PRT <213> Homo sapiens <400> 735 Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 1 5 10 15 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 20 25 30 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 35 40 45 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 50 55 60 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 65 70 75 80 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser 85 90 95 Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser 115 120 125 Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr 130 135 140 Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 145 150 155 160 Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 736 <211> 364 <212> PRT <213> Homo sapiens <400> 736 Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 1 5 10 15 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 35 40 45 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 50 55 60 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 65 70 75 80 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe 85 90 95 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 100 105 110 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 130 135 140 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190 Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 195 200 205 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 210 215 220 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240 Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 260 265 270 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 275 280 285 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 290 295 300 Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320 Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 325 330 335 Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 340 345 350 Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 355 360 <210> 737 <211> 364 <212> PRT <213> Homo sapiens <400> 737 Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 1 5 10 15 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 35 40 45 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 50 55 60 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 65 70 75 80 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe 85 90 95 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 100 105 110 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 130 135 140 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190 Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 195 200 205 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 210 215 220 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240 Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 260 265 270 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 275 280 285 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 290 295 300 Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320 Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 325 330 335 Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 340 345 350 Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 355 360 <210> 738 <211> 370 <212> PRT <213> Homo sapiens <400> 738 Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 1 5 10 15 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 20 25 30 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 35 40 45 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 50 55 60 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 65 70 75 80 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Arg Pro Asp Ser Ser 85 90 95 Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser 115 120 125 Pro Ile Ser Ser Asn Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr 130 135 140 Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu 145 150 155 160 Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Phe Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 739 <211> 370 <212> PRT <213> Homo sapiens <400> 739 Ala Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp 1 5 10 15 Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu 20 25 30 Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln 35 40 45 Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 50 55 60 Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 65 70 75 80 Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 85 90 95 Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 100 105 110 Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His 115 120 125 Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp 130 135 140 Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp 145 150 155 160 Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 740 <211> 370 <212> PRT <213> Homo sapiens <400> 740 Ala Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 1 5 10 15 Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 20 25 30 Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 35 40 45 Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg 50 55 60 Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile 65 70 75 80 Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp 85 90 95 Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 100 105 110 Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln 115 120 125 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 130 135 140 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 145 150 155 160 Asp Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 741 <211> 370 <212> PRT <213> Homo sapiens <400> 741 Ala Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 1 5 10 15 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 20 25 30 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 35 40 45 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 50 55 60 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 65 70 75 80 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 85 90 95 Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser 115 120 125 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 130 135 140 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 145 150 155 160 Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 742 <211> 364 <212> PRT <213> Homo sapiens <400> 742 Ala Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val 1 5 10 15 Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu 20 25 30 Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 35 40 45 Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln 50 55 60 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 65 70 75 80 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 85 90 95 Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 100 105 110 Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 115 120 125 Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 130 135 140 Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190 Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 195 200 205 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 210 215 220 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240 Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 260 265 270 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 275 280 285 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 290 295 300 Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320 Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 325 330 335 Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 340 345 350 Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 355 360 <210> 743 <211> 355 <212> PRT <213> Homo sapiens <400> 743 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly 165 170 175 Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln 180 185 190 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp 195 200 205 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His 210 215 220 Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala 225 230 235 240 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu 245 250 255 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 260 265 270 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln 275 280 285 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu 290 295 300 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala 305 310 315 320 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser 325 330 335 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 340 345 350 Ala Gln Pro 355 <210> 744 <211> 370 <212> PRT <213> Homo sapiens <400> 744 Ala Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 1 5 10 15 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 20 25 30 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 35 40 45 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 50 55 60 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 65 70 75 80 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 85 90 95 Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser 115 120 125 Phe Gln His Ser Pro Ile Ser Ser Asp Ser Ala Val Lys Ile Arg Glu 130 135 140 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 145 150 155 160 Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 745 <211> 366 <212> PRT <213> Homo sapiens <400> 745 Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 1 5 10 15 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 20 25 30 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Tyr Ala Phe Gln Pro 35 40 45 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 50 55 60 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 65 70 75 80 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Arg Pro Asp Ser Ser 85 90 95 Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 115 120 125 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 130 135 140 Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Tyr Val Glu 145 150 155 160 Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile 165 170 175 Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala 180 185 190 Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 195 200 205 Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 210 215 220 Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 225 230 235 240 Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 245 250 255 Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 260 265 270 Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 275 280 285 Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp 290 295 300 Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro 305 310 315 320 Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 325 330 335 Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 340 345 350 Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 355 360 365 <210> 746 <211> 364 <212> PRT <213> Homo sapiens <400> 746 Ala Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His 1 5 10 15 Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 35 40 45 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Phe Arg Cys Leu 50 55 60 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 65 70 75 80 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe 85 90 95 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 100 105 110 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125 Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 130 135 140 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190 Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 195 200 205 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 210 215 220 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240 Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 260 265 270 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 275 280 285 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 290 295 300 Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320 Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 325 330 335 Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 340 345 350 Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 355 360 <210> 747 <211> 378 <212> PRT <213> Homo sapiens <400> 747 Ala Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 1 5 10 15 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 20 25 30 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 35 40 45 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 50 55 60 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 65 70 75 80 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 85 90 95 Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 115 120 125 Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 130 135 140 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 145 150 155 160 Tyr Pro Val Thr Val Ala Ser Asn Leu Tyr Val Glu Gly Gly Gly Gly 165 170 175 Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro 180 185 190 Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro Leu Gly 195 200 205 Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln 210 215 220 Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys 225 230 235 240 Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 245 250 255 Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala 260 265 270 Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu 275 280 285 Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly 290 295 300 Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr 305 310 315 320 Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 325 330 335 Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala 340 345 350 Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser 355 360 365 Tyr Arg Val Leu Arg His Leu Ala Gln Pro 370 375 <210> 748 <211> 364 <212> PRT <213> Homo sapiens <400> 748 Ala Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 1 5 10 15 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 20 25 30 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 35 40 45 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 50 55 60 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 65 70 75 80 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 85 90 95 Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly 100 105 110 Ala Thr Ala Pro Thr Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 115 120 125 Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu 130 135 140 Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190 Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 195 200 205 Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 210 215 220 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240 Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255 Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 260 265 270 Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 275 280 285 Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 290 295 300 Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320 Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 325 330 335 Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 340 345 350 Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 355 360 <210> 749 <211> 370 <212> PRT <213> Homo sapiens <400> 749 Ala Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 1 5 10 15 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 20 25 30 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 35 40 45 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 50 55 60 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 65 70 75 80 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 85 90 95 Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly 100 105 110 Ala Thr Ala Pro Thr Ala Gly Gln Pro Pro Leu Thr Gln Asp Cys Ser 115 120 125 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 130 135 140 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 145 150 155 160 Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 750 <211> 378 <212> PRT <213> Homo sapiens <400> 750 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 115 120 125 Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 130 135 140 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 145 150 155 160 Pro Val Thr Val Ala Ser Asn Leu Gln Tyr Val Glu Gly Gly Gly Gly 165 170 175 Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro 180 185 190 Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro Leu Gly 195 200 205 Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln 210 215 220 Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys 225 230 235 240 Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 245 250 255 Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala 260 265 270 Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu 275 280 285 Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly 290 295 300 Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr 305 310 315 320 Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 325 330 335 Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala 340 345 350 Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser 355 360 365 Tyr Arg Val Leu Arg His Leu Ala Gln Pro 370 375 <210> 751 <211> 378 <212> PRT <213> Homo sapiens <400> 751 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Pro Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 115 120 125 Ser Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 130 135 140 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 145 150 155 160 Pro Val Thr Val Ala Ser Asn Leu Gln Tyr Val Glu Gly Gly Gly Gly 165 170 175 Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro 180 185 190 Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro Leu Gly 195 200 205 Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln 210 215 220 Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys 225 230 235 240 Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 245 250 255 Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala 260 265 270 Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu 275 280 285 Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly 290 295 300 Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr 305 310 315 320 Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 325 330 335 Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala 340 345 350 Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser 355 360 365 Tyr Arg Val Leu Arg His Leu Ala Gln Pro 370 375 <210> 752 <211> 370 <212> PRT <213> Homo sapiens <400> 752 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly Ala 100 105 110 Thr Ala Pro Thr Ala Gly Gln Pro Pro Leu Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Thr Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser 195 200 205 Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly 210 215 220 Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240 Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro 245 250 255 Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser 260 265 270 Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu 275 280 285 Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu 290 295 300 Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu 305 310 315 320 Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe 325 330 335 Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350 Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365 Gln Pro 370 <210> 753 <211> 347 <212> PRT <213> Homo sapiens <400> 753 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Val Glu Thr Val Phe His Arg Val Ser Gln Asp Gly Leu Asp Leu Leu 100 105 110 Thr Ser Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp 115 120 125 Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr 130 135 140 Pro Val Thr Val Ala Ser Asn Leu Gln Tyr Val Glu Gly Gly Gly Gly 145 150 155 160 Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Thr Pro Leu 165 170 175 Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu 180 185 190 Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu 195 200 205 Cys Ala Thr Asn Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 210 215 220 His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln 225 230 235 240 Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe 245 250 255 Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu 260 265 270 Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr 275 280 285 Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln 290 295 300 Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg 305 310 315 320 Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val 325 330 335 Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 340 345 <210> 754 <211> 384 <212> PRT <213> Homo sapiens <400> 754 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu 100 105 110 Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu 115 120 125 Ser His Lys Ser Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser 130 135 140 Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile 145 150 155 160 Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys 165 170 175 Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile 180 185 190 Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala 195 200 205 Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu 210 215 220 Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp 225 230 235 240 Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln 245 250 255 Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala 260 265 270 Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu 275 280 285 Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu 290 295 300 Arg His Leu Ala Gln Pro Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly 305 310 315 320 Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys 325 330 335 Glu Ser His Lys Ser Pro Asn Met Ala Thr Gln Asp Cys Ser Phe Gln 340 345 350 His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser 355 360 365 Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 370 375 380 <210> 755 <211> 349 <212> PRT <213> Homo sapiens <400> 755 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Glu Pro Lys Ser Pro Asp Thr His 35 40 45 Thr Ser Pro Pro Ser Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro 50 55 60 Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly 65 70 75 80 Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys 85 90 95 His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp 100 105 110 Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys 115 120 125 Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln 130 135 140 Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu 145 150 155 160 Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu 165 170 175 Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro 180 185 190 Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala 195 200 205 Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 210 215 220 Leu Ala Gln Pro Ser Ala Glu Pro Lys Ser Pro Asp Thr His Thr Ser 225 230 235 240 Pro Pro Ser Pro Gly Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly 245 250 255 Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr 260 265 270 Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu 275 280 285 Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu 290 295 300 Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu 305 310 315 320 Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg 325 330 335 Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 340 345 <210> 756 <211> 347 <212> PRT <213> Homo sapiens <400> 756 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Trp Gln Gly Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Pro Lys Ser Pro Asp Thr His Thr 85 90 95 Ser Pro Pro Ser Pro Gly Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro 100 105 110 Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly 115 120 125 Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Tyr Lys Leu Cys His 130 135 140 Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala 145 150 155 160 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu 165 170 175 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 180 185 190 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln 195 200 205 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu 210 215 220 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala 225 230 235 240 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser 245 250 255 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 260 265 270 Ala Gln Pro Ser Ala Glu Pro Lys Ser Pro Asp Thr His Thr Ser Pro 275 280 285 Pro Ser Pro Gly Lys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe 290 295 300 Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu 305 310 315 320 Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu 325 330 335 Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 340 345 <210> 757 <211> 355 <212> PRT <213> Homo sapiens <400> 757 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Ser Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Ser Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly 165 170 175 Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln 180 185 190 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp 195 200 205 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Asn Lys Leu Cys His 210 215 220 Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala 225 230 235 240 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu 245 250 255 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 260 265 270 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln 275 280 285 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu 290 295 300 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala 305 310 315 320 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser 325 330 335 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 340 345 350 Ala Gln Pro 355 <210> 758 <211> 370 <212> PRT <213> Homo sapiens <400> 758 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 225 230 235 240 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Ser 245 250 255 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 260 265 270 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 275 280 285 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 290 295 300 Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 305 310 315 320 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Ser Ser 325 330 335 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 340 345 350 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 355 360 365 Leu Gln 370 <210> 759 <211> 355 <212> PRT <213> Homo sapiens <400> 759 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Ser Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Ser Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly 165 170 175 Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln 180 185 190 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp 195 200 205 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Asn Lys Leu Cys His 210 215 220 Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala 225 230 235 240 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu 245 250 255 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 260 265 270 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln 275 280 285 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu 290 295 300 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala 305 310 315 320 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser 325 330 335 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 340 345 350 Ala Gln Pro 355 <210> 760 <211> 370 <212> PRT <213> Homo sapiens <400> 760 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 225 230 235 240 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 245 250 255 Ala Phe Gln Pro Pro Pro Ser Ser Leu Arg Phe Val Gln Thr Asn Ile 260 265 270 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 275 280 285 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Ser Gln 290 295 300 Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 305 310 315 320 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser 325 330 335 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 340 345 350 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 355 360 365 Leu Gln 370 <210> 761 <211> 334 <212> PRT <213> Homo sapiens <400> 761 Ala Thr Gln Asp Ser Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Ser Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140 Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala 145 150 155 160 Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 165 170 175 Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 180 185 190 Glu Lys Leu Cys Ala Thr Asn Lys Leu Cys His Pro Glu Glu Leu Val 195 200 205 Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 210 215 220 Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 225 230 235 240 Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 245 250 255 Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp 260 265 270 Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro 275 280 285 Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 290 295 300 Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 305 310 315 320 Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 325 330 <210> 762 <211> 334 <212> PRT <213> Homo sapiens <400> 762 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Ser Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Ser Gln Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140 Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala 145 150 155 160 Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 165 170 175 Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 180 185 190 Glu Lys Leu Cys Ala Thr Asn Lys Leu Cys His Pro Glu Glu Leu Val 195 200 205 Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 210 215 220 Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 225 230 235 240 Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 245 250 255 Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp 260 265 270 Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro 275 280 285 Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 290 295 300 Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 305 310 315 320 Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 325 330 <210> 763 <211> 326 <212> PRT <213> Homo sapiens <400> 763 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly 130 135 140 Ser Gly Gly Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser 145 150 155 160 Leu Pro Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile 165 170 175 Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Asn Lys 180 185 190 Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile 195 200 205 Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala 210 215 220 Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu 225 230 235 240 Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp 245 250 255 Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln 260 265 270 Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala 275 280 285 Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu 290 295 300 Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu 305 310 315 320 Arg His Leu Ala Gln Pro 325 <210> 764 <211> 334 <212> PRT <213> Homo sapiens <400> 764 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Ser Gln Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140 Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala 145 150 155 160 Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 165 170 175 Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 180 185 190 Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 195 200 205 Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 210 215 220 Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 225 230 235 240 Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 245 250 255 Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp 260 265 270 Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro 275 280 285 Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 290 295 300 Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 305 310 315 320 Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 325 330 <210> 765 <211> 334 <212> PRT <213> Homo sapiens <400> 765 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Arg 115 120 125 Leu Glu Leu Gln Ser Gln Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140 Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala 145 150 155 160 Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 165 170 175 Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 180 185 190 Glu Lys Leu Cys Ala Thr Asn Lys Leu Cys His Pro Glu Glu Leu Val 195 200 205 Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 210 215 220 Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 225 230 235 240 Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 245 250 255 Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp 260 265 270 Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro 275 280 285 Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 290 295 300 Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 305 310 315 320 Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 325 330 <210> 766 <211> 352 <212> PRT <213> Homo sapiens <400> 766 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly 165 170 175 Gly Ser Asn Met Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 180 185 190 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 195 200 205 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser 210 215 220 Gly Gly Ser Gly Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln 225 230 235 240 Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys 245 250 255 Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 260 265 270 Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala 275 280 285 Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu 290 295 300 Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly 305 310 315 320 Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr 325 330 335 Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro 340 345 350 <210> 767 <211> 367 <212> PRT <213> Homo sapiens <400> 767 Ala Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg 1 5 10 15 Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val 20 25 30 Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Ser Gly Gly Ser Gly 35 40 45 Gly Ser Gln Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile 50 55 60 Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys 65 70 75 80 Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile 85 90 95 Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala 100 105 110 Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu 115 120 125 Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp 130 135 140 Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln 145 150 155 160 Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Tyr Val Glu Gly 165 170 175 Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn 180 185 190 Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asp 195 200 205 Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp 210 215 220 Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu 225 230 235 240 Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln 245 250 255 Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu 260 265 270 Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr 275 280 285 Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser 290 295 300 Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 305 310 315 320 Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe Gln His 325 330 335 Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp 340 345 350 Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 355 360 365 <210> 768 <211> 344 <212> PRT <213> Homo sapiens <400> 768 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 115 120 125 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 130 135 140 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asp Glu 180 185 190 Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met 195 200 205 Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu 210 215 220 Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro 225 230 235 240 Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu 245 250 255 Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg 260 265 270 Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser 275 280 285 Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 290 295 300 Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 305 310 315 320 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 325 330 335 Val Thr Val Ala Ser Asn Leu Gln 340 <210> 769 <211> 335 <212> PRT <213> Homo sapiens <400> 769 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190 Pro Asn Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 195 200 205 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 210 215 220 Asn Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys 225 230 235 240 Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu 245 250 255 Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn 260 265 270 Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser 275 280 285 Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr 290 295 300 Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe 305 310 315 320 Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 325 330 335 <210> 770 <211> 550 <212> PRT <213> Homo sapiens <400> 770 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly 165 170 175 Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln 180 185 190 Ser Phe Leu Leu Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp 195 200 205 Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His 210 215 220 Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala 225 230 235 240 Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu 245 250 255 Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala 260 265 270 Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln 275 280 285 Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu 290 295 300 Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala 305 310 315 320 Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser 325 330 335 His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 340 345 350 Ala Gln Pro Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser 355 360 365 Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His 370 375 380 Lys Ser Pro Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 385 390 395 400 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 405 410 415 Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe 420 425 430 Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val 435 440 445 Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val 450 455 460 Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu 465 470 475 480 Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 485 490 495 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr 500 505 510 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 515 520 525 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 530 535 540 Val Ala Ser Asn Leu Gln 545 550 <210> 771 <211> 544 <212> PRT <213> Homo sapiens <400> 771 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 225 230 235 240 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 245 250 255 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 260 265 270 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 275 280 285 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 290 295 300 Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 305 310 315 320 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser 325 330 335 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 340 345 350 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 355 360 365 Leu Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly 370 375 380 Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys 385 390 395 400 Ser Pro Asn Met Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile 405 410 415 Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu 420 425 430 Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu 435 440 445 Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg 450 455 460 Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val 465 470 475 480 Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro 485 490 495 Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu 500 505 510 Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn 515 520 525 Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu 530 535 540 <210> 772 <211> 565 <212> PRT <213> Homo sapiens <400> 772 Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 1 5 10 15 Lys Ser Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 20 25 30 Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45 Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 50 55 60 Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 65 70 75 80 Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 85 90 95 Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 100 105 110 Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 115 120 125 Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140 Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 145 150 155 160 Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro Tyr 165 170 175 Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser 180 185 190 Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205 Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220 Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln 225 230 235 240 Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys 245 250 255 Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile 260 265 270 Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro 275 280 285 Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln 290 295 300 Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 305 310 315 320 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser 325 330 335 Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu 340 345 350 Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn 355 360 365 Leu Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly 370 375 380 Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys 385 390 395 400 Ser Pro Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu 405 410 415 Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser 420 425 430 Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val 435 440 445 Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln 450 455 460 Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala 465 470 475 480 Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu 485 490 495 Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly 500 505 510 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln 515 520 525 Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys 530 535 540 Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val 545 550 555 560 Ala Ser Asn Leu Gln 565 <210> 773 <211> 502 <212> PRT <213> Homo sapiens <400> 773 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile 115 120 125 Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175 Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys 180 185 190 Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn 195 200 205 Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys 210 215 220 Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys 225 230 235 240 Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 245 250 255 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys 260 265 270 Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg 275 280 285 Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser 290 295 300 Asn Leu Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser 305 310 315 320 Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu Ser His 325 330 335 Lys Ser Pro Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 340 345 350 Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 355 360 365 Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe 370 375 380 Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val 385 390 395 400 Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val 405 410 415 Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu 420 425 430 Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 435 440 445 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr 450 455 460 Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val 465 470 475 480 Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr 485 490 495 Val Ala Ser Asn Leu Gln 500 <210> 774 <211> 562 <212> PRT <213> Homo sapiens <400> 774 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly 165 170 175 Gly Ser Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu 180 185 190 Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser 195 200 205 Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val 210 215 220 Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln 225 230 235 240 Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala 245 250 255 Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu 260 265 270 Gln Cys Gln Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly 275 280 285 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln 290 295 300 Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys 305 310 315 320 Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val 325 330 335 Ala Ser Asn Leu Gln Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu 340 345 350 Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro Ser Lys Glu 355 360 365 Ser His Lys Ser Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser 370 375 380 Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile 385 390 395 400 Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys Leu Cys Ala Thr Tyr Lys 405 410 415 Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile 420 425 430 Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu Ala 435 440 445 Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly Leu 450 455 460 Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu Asp 465 470 475 480 Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln Gln 485 490 495 Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly Ala 500 505 510 Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val Leu 515 520 525 Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val Leu 530 535 540 Arg His Leu Ala Gln Pro Ser Thr Pro Ser Thr Pro Gly Ser Glu Phe 545 550 555 560 Gly Ser <210> 775 <211> 490 <212> PRT <213> Homo sapiens <400> 775 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser 115 120 125 Ser Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln 130 135 140 Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gln Tyr Val Glu Gly Gly 145 150 155 160 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro 165 170 175 Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190 Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro Pro Asn 195 200 205 Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp Ile Leu 210 215 220 Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240 Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu Arg Asn 245 250 255 Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys Leu Thr 275 280 285 Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln Tyr Val Glu 290 295 300 Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro Ile Ser Thr Ile 305 310 315 320 Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala 325 330 335 Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln Arg 340 345 350 Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly Leu 355 360 365 Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala Phe 370 375 380 Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser Arg 385 390 395 400 Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp Ile 405 410 415 Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro Asp 420 425 430 Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 435 440 445 Gly Gly Gly Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser 450 455 460 Asp Phe Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp 465 470 475 480 Tyr Pro Val Thr Val Ala Ser Asn Leu Gln 485 490 <210> 776 <211> 398 <212> PRT <213> Homo sapiens <400> 776 Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 1 5 10 15 Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 20 25 30 Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 35 40 45 Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 50 55 60 Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 65 70 75 80 Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 85 90 95 Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gln Asp Cys Ser Phe 115 120 125 Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 130 135 140 Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160 Gln Glu Phe Lys Leu Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 165 170 175 Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 180 185 190 Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 195 200 205 Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 210 215 220 Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 225 230 235 240 Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Ala Val Ser Ala 245 250 255 Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 260 265 270 Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 275 280 285 Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 290 295 300 Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 305 310 315 320 Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 325 330 335 Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 340 345 350 Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 355 360 365 Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 370 375 380 Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 385 390 395 <210> 777 <211> 377 <212> PRT <213> Homo sapiens <400> 777 Ala Thr Gln Asp Cys Ser Phe Gln His Ser Pro Ile Ser Ser Asp Phe 1 5 10 15 Ala Val Lys Ile Arg Glu Leu Ser Asp Tyr Leu Leu Gln Asp Tyr Pro 20 25 30 Val Thr Val Ala Ser Asn Leu Gln Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 Trp Arg Leu Val Leu Ala Gln Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60 Ala Gly Ser Lys Met Gln Gly Leu Leu Glu Arg Val Asn Thr Glu Ile 65 70 75 80 His Phe Val Thr Lys Cys Ala Phe Gln Pro Pro Pro Ser Cys Leu Arg 85 90 95 Phe Val Gln Thr Asn Ile Ser Arg Leu Leu Gln Glu Thr Ser Glu Gln 100 105 110 Leu Val Ala Leu Lys Pro Trp Ile Thr Arg Gln Asn Phe Ser Arg Cys 115 120 125 Leu Glu Leu Gln Cys Gln Pro Asp Ser Ser Thr Leu Glu Phe Lys Leu 130 135 140 Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 145 150 155 160 Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 165 170 175 Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 180 185 190 Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 195 200 205 Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 210 215 220 Asp Tyr Asn Ser Thr Leu Arg Ala Val Ser Ala Leu Pro Ile Gln His 225 230 235 240 Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 245 250 255 Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 260 265 270 Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 275 280 285 Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 290 295 300 Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 305 310 315 320 Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 325 330 335 Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 340 345 350 Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 355 360 365 Lys Ser Phe Ser Arg Thr Pro Gly Lys 370 375 <210> 778 <211> 4 <212> PRT <213> Homo sapiens <400> 778 Gly Gly Gly Ser <210> 779 <211> 8 <212> PRT <213> Homo sapiens <400> 779 Gly Gly Gly Ser Gly Gly Gly Ser 1 5 <210> 780 <211> 12 <212> PRT <213> Homo sapiens <400> 780 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 1 5 10 <210> 781 <211> 7 <212> PRT <213> Homo sapiens <400> 781 Ser Gly Gly Ser Gly Gly Ser 1 5 <210> 782 <211> 5 <212> PRT <213> Homo sapiens <400> 782 Glu Phe Gly Asn Met 1 5 <210> 783 <211> 6 <212> PRT <213> Homo sapiens <400> 783 Glu Phe Gly Gly Asn Met 1 5 <210> 784 <211> 9 <212> PRT <213> Homo sapiens <400> 784 Glu Phe Gly Gly Asn Gly Gly Asn Met 1 5 <210> 785 <211> 7 <212> PRT <213> Homo sapiens <400> 785 Gly Gly Ser Asp Met Ala Gly 1 5 <210> 786 <211> 5 <212> PRT <213> Homo sapiens <400> 786 Ser Gly Gly Asn Gly 1 5 <210> 787 <211> 10 <212> PRT <213> Homo sapiens <400> 787 Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly 1 5 10 <210> 788 <211> 15 <212> PRT <213> Homo sapiens <400> 788 Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly 1 5 10 15 <210> 789 <211> 10 <212> PRT <213> Homo sapiens <400> 789 Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 1 5 10 <210> 790 <211> 15 <212> PRT <213> Homo sapiens <400> 790 Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 1 5 10 15 <210> 791 <211> 6 <212> PRT <213> Homo sapiens <400> 791 Gly Gly Gly Ser Gly Gly 1 5 <210> 792 <211> 7 <212> PRT <213> Homo sapiens <400> 792 Gly Gly Gly Ser Gly Gly Gly 1 5 <210> 793 <211> 10 <212> PRT <213> Homo sapiens <400> 793 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 1 5 10 <210> 794 <211> 13 <212> PRT <213> Homo sapiens <400> 794 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 1 5 10 <210> 795 <211> 15 <212> PRT <213> Homo sapiens <400> 795 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 1 5 10 15 <210> 796 <211> 21 <212> PRT <213> Homo sapiens <400> 796 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 1 5 10 15 Gly Gly Gly Ser Gly 20 <210> 797 <211> 21 <212> PRT <213> Homo sapiens <400> 797 Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly Ala Thr Ala Pro Thr Ala 1 5 10 15 Gly Gln Pro Pro Leu 20 <210> 798 <211> 15 <212> PRT <213> Homo sapiens <400> 798 Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly Ala Thr Ala Pro Thr 1 5 10 15 <210> 799 <211> 16 <212> PRT <213> Homo sapiens <400> 799 Val Glu Thr Val Phe His Arg Val Ser Gln Asp Gly Leu Leu Thr Ser 1 5 10 15 <210> 800 <211> 36 <212> PRT <213> Homo sapiens <400> 800 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Gly Gly Gly 1 5 10 15 Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 20 25 30 Gly Gly Gly Ser 35 <210> 801 <211> 24 <212> PRT <213> Homo sapiens <400> 801 Ile Ser Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Ser Pro Pro 1 5 10 15 Ser Lys Glu Ser His Lys Ser Pro 20 <210> 802 <211> 28 <212> PRT <213> Homo sapiens <400> 802 Ile Glu Gly Arg Ile Ser Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn 1 5 10 15 Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 20 25 <210> 803 <211> 112 <212> PRT <213> Homo sapiens <400> 803 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 <210> 804 <211> 112 <212> PRT <213> Homo sapiens <400> 804 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg 1 5 10 15 Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 <210> 805 <211> 112 <212> PRT <213> Homo sapiens <400> 805 Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Val 1 5 10 15 Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe 35 40 45 Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile 50 55 60 Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu 85 90 95 Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 <210> 806 <211> 111 <212> PRT <213> Homo sapiens <400> 806 Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg Pro 1 5 10 15 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45 Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile Glu Ala Ile Leu 50 55 60 Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80 His Pro Ile Ile Ile Lys Ala Gly Asp Trp Gln Glu Phe Arg Glu Lys 85 90 95 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gln Ala Gln Glu Gln Gln 100 105 110 <210> 807 <211> 33 <212> DNA <213> Homo sapiens <400> 807 ctgaccatgg cnacccagga ctgctccttc caa 33 <210> 808 <211> 32 <212> DNA <213> Homo sapiens <400> 808 actgaagctt agggctgaca ctgcagctcc ag 32 <210> 809 <211> 32 <212> DNA <213> Homo sapiens <400> 809 actgaagctt acagggttga ggagtcgggc tg 32 <210> 810 <211> 46 <212> DNA <213> Homo sapiens <400> 810 gactgccatg gcnacycagg aytgytcytt ycaacacagc cccatc 46 <210> 811 <211> 46 <212> DNA <213> Homo sapiens <400> 811 gactgccatg gcnacycagg aytgytcytt ycaacacagc cccatc 46 <210> 812 <211> 22 <212> DNA <213> Homo sapiens <400> 812 tgtccaaact catcaatgta tc 22 <210> 813 <211> 38 <212> DNA <213> Homo sapiens <400> 813 catggccatg gccgacgagg agctctgcgg gggcctct 38 <210> 814 <211> 36 <212> DNA <213> Homo sapiens <400> 814 gctagaagct tactgcaggt tggaggccac ggtgac 36 <210> 815 <211> 38 <212> DNA <213> Homo sapiens <400> 815 catggccatg gcctccaaga tgcaaggctt gctggagc 38 <210> 816 <211> 36 <212> DNA <213> Homo sapiens <400> 816 gctagaagct tacccagcga cagtcttgag ccgctc 36 <210> 817 <211> 36 <212> DNA <213> Homo sapiens <400> 817 catggccatg gcccccccca gctgtcttcg cttcgt 36 <210> 818 <211> 37 <212> DNA <213> Homo sapiens <400> 818 gctagaagct tagggctgaa aggcacattt ggtgaca 37 <210> 819 <211> 42 <212> DNA <213> Homo sapiens <400> 819 ccctgtctgg cggcaacggc acccaggact gctccttcca ac 42 <210> 820 <211> 48 <212> DNA <213> Homo sapiens <400> 820 gcggtaacgg cagtggaggt aatggcaccc aggactgctc cttccaac 48 <210> 821 <211> 57 <212> DNA <213> Homo sapiens <400> 821 acggcagtgg tggcaatggg agcggcggaa atggaaccca ggactgctcc ttccaac 57 <210> 822 <211> 38 <212> DNA <213> Homo sapiens <400> 822 gtgccgttgc cgccagacag ggttgaggag tcgggctg 38 <210> 823 <211> 48 <212> DNA <213> Homo sapiens <400> 823 attacctcca ctgccgttac cgcctgacag ggttgaggag tcgggctg 48 <210> 824 <211> 54 <212> DNA <213> Homo sapiens <400> 824 gctcccattg ccaccactgc cgttacctcc agacagggtt gaggagtcgg gctg 54 <210> 825 <211> 60 <212> DNA <213> Homo sapiens <400> 825 gatgaggatc cggtggcaat gggagcggcg gaaatggaac ccaggactgc tccttccacc 60 60 <210> 826 <211> 45 <212> DNA <213> Homo sapiens <400> 826 gatgacggat ccgttacctc cagacagggt tgaggagtcg ggctg 45 <210> 827 <211> 46 <212> DNA <213> Homo sapiens <400> 827 gatgacggat ccggaggtaa tggcacccag gactgctcct tccaac 46 <210> 828 <211> 29 <212> DNA <213> Homo sapiens <400> 828 gactgccatg gccgacgagg agctctgcg 29 <210> 829 <211> 28 <212> DNA <213> Homo sapiens <400> 829 gactcaagct tactgcaggt tggaggcc 28 <210> 830 <211> 39 <212> DNA <213> Homo sapiens <400> 830 gactcgggat ccggaggttc tggcacccag gactgctcc 39 <210> 831 <211> 41 <212> DNA <213> Homo sapiens <400> 831 gactgggatc cggtggcagt gggagcggcg gatctggaac c 41 <210> 832 <211> 39 <212> DNA <213> Homo sapiens <400> 832 gacttgggat ccactacctc cagacagggt tgaggagtc 39 <210> 833 <211> 39 <212> DNA <213> Homo sapiens <400> 833 actgacggat ccaccgccca gggttgagga gtcgggctg 39 <210> 834 <211> 51 <212> DNA <213> Homo sapiens <400> 834 actgacggat ccacctcctg acccaccgcc cagggttgag gagtcgggct g 51 <210> 835 <211> 63 <212> DNA <213> Homo sapiens <400> 835 actgacggat ccacctcctg acccacctcc tgacccaccg cccagggttg aggagtcggg 60 ctg 63 <210> 836 <211> 28 <212> DNA <213> Homo sapiens <400> 836 acgtaaagct tacagggttg aggagtcg 28 <210> 837 <211> 40 <212> DNA <213> Homo sapiens <400> 837 gtcagtggat ccggaggtac ccaggactgc tccttccaac 40 <210> 838 <211> 43 <212> DNA <213> Homo sapiens <400> 838 gtcagtggat ccggaggtgg cacccaggac tgctccttcc aac 43 <210> 839 <211> 60 <212> DNA <213> Homo sapiens <400> 839 tcagtggatc cggaggtggc tcagggggag gtagtggtac ccaggactgc tccttccaac 60 60 <210> 840 <211> 27 <212> DNA <213> Homo sapiens <400> 840 tagtccatgg ccacccagga ctgctcc 27 <210> 841 <211> 31 <212> DNA <213> Homo sapiens <400> 841 gcattacgta gggctgacac tgcagctcca g 31 <210> 842 <211> 31 <212> DNA <213> Homo sapiens <400> 842 gcattacgta cagggttgag gagtcgggct g 31 <210> 843 <211> 37 <212> DNA <213> Homo sapiens <400> 843 gtcagaccat ggccgattac ccagtcaccg tggcctc 37 <210> 844 <211> 39 <212> DNA <213> Homo sapiens <400> 844 tctgacaagc ttattgaagc aggtagtcag acagctcac 39 <210> 845 <211> 37 <212> DNA <213> Homo sapiens <400> 845 gtcagcccat ggccgcctcc aacctgcagg acgagga 37 <210> 846 <211> 37 <212> DNA <213> Homo sapiens <400> 846 tctgacaagc ttacacggtg actgggtaac ttgaagc 37 <210> 847 <211> 38 <212> DNA <213> Homo sapiens <400> 847 gtcagaccat ggccgtcgct gggtccaaga tgcaaggc 38 <210> 848 <211> 37 <212> DNA <213> Homo sapiens <400> 848 tctgacaagc ttaagtcttg agccgctcca tccagcg 37 <210> 849 <211> 38 <212> DNA <213> Homo sapiens <400> 849 gtcagaccat ggcccgcttc gtccagacca acatctcc 38 <210> 850 <211> 36 <212> DNA <213> Homo sapiens <400> 850 tctgacaagc ttaaagacag ctgggggggg gctgaa 36 <210> 851 <211> 38 <212> DNA <213> Homo sapiens <400> 851 gtcagaccat ggccaccaac atctcccgcc tcctgcag 38 <210> 852 <211> 37 <212> DNA <213> Homo sapiens <400> 852 ctcgacaagc ttactggacg aagcgaagac agctggg 37 <210> 853 <211> 33 <212> DNA <213> Homo sapiens <400> 853 gatcacatgt ctacaaatca agatctgcct gtg 33 <210> 854 <211> 30 <212> DNA <213> Homo sapiens <400> 854 gatcgaattc gttgtcttgg atgaaaggga 30 <210> 855 <211> 32 <212> DNA <213> Homo sapiens <400> 855 acttgaattc atcatcctgg gcctgttcgg gc 32 <210> 856 <211> 30 <212> DNA <213> Homo sapiens <400> 856 actcaagctt agaagctccc cagcgcctcc 30 <210> 857 <211> 64 <212> DNA <213> Homo sapiens <400> 857 ggatccacca tgagccgcct gcccgtcctg ctcctgctcc aactcctggt ccgccccgcc 60 atgg 64 <210> 858 <211> 174 <212> PRT <213> Homo sapiens <220> <221> MUTAGEN <222> (1)..(1) <223> Xaa at position 1 is Thr, Ser, Arg, Tyr or Gly <220> <221> MUTAGEN <222> (2)..(2) <223> Xaa at position 2 is Pro or Leu <220> <221> MUTAGEN <222> (3)..(3) <223> Xaa at position 3 is Leu, Arg, Tyr or Ser <220> <221> MUTAGEN <222> (13)..(13) <223> Xaa at position 13 is Phe, Ser, His, Thr or Pro <220> <221> MUTAGEN <222> (16)..(16) <223> Xaa at position 16 is Lys, Pro, Ser, thr or His <220> <221> MUTAGEN <222> (17)..(17) <223> Xaa at position 17 is Cys, Ser, Gly, Ala, Ile, Tyr or Arg <220> <221> MUTAGEN <222> (18)..(18) <223> Xaa at position 18 is Leu, Thr, Pro, His Ile or Cys <220> <221> MUTAGEN <222> (22)..(22) <223> Xaa at position 22 is Arg, Tyr, Ser, Thr or Ala <220> <221> MUTAGEN <222> (24)..(24) <223> Xaa at position 24 is Ile, Pro, Tyr or Leu <220> <221> MUTAGEN <222> (27)..(27) <223> Xaa at position 27 is Asp or Gly <220> <221> MUTAGEN <222> (30)..(30) <223> Xaa at position 30 is Ala, Ile, Leu or Gly <220> <221> MUTAGEN <222> (34)..(34) <223> Xaa at position 34 is Lys or Ser <220> <221> MUTAGEN <222> (36)..(36) <223> Xaa at position 36 is Cys or Ser <220> <221> MUTAGEN <222> (42)..(42) <223> Xaa at position 42 is Cys or Ser <220> <221> MUTAGEN <222> (43)..(43) <223> Xaa at position 43 is His, Thr, Gly, Val, Lys, Trp, Ala, Arg, Cys or Leu <220> <221> MUTAGEN <222> (44)..(44) <223> Xaa at position 44 is Pro, Gly, Arg, Asp, Val, Ala, His, Trp, Gln or Thr <220> <221> MUTAGEN <222> (46)..(46) <223> Xaaat position 46 is Glu, Arg, Phe, Arg, Ile or Ala <220> <221> MUTAGEN <222> (47)..(47) <223> Xaa at position 47 is Leu or Thr <220> <221> MUTAGEN <222> (49)..(49) <223> Xaa at position 49 is Leu, Phe, Arg or Ser <220> <221> MUTAGEN <222> (50)..(50) <223> Xaa at position50 is Leu, Ile, His, Pro or Tyr <220> <221> MUTAGEN <222> (54)..(54) <223> Xaa at position 54 is Leu or His <220> <221> MUTAGEN <222> (64)..(64) <223> Xaa at position 64 is Cys or Ser <220> <221> MUTAGEN <222> (67)..(67) <223> Xaa at position 67 is Gln, Lys, Leu or Cys <220> <221> MUTAGEN <222> (70)..(70) <223> Xaa at position 70 is Gln, Pro, Leu, Arg or Ser <220> <221> MUTAGEN <222> (74)..(74) <223> Xaa at position 74 is Cys or Ser <220> <221> MUTAGEN <222> (104)..(104) <223> Xaa at position 104 is Asp, Gly or Val <220> <221> MUTAGEN <222> (108)..(108) <223> Xaa at position 108 is Leu, Ala, Val, Arg, Trp, Gln or Gly <220> <221> MUTAGEN <222> (115)..(115) <223> Xaa at position 115 is Thr, His, Leu or Ala <220> <221> MUTAGEN <222> (120)..(120) <223> Xaa at osition 120 is Gln, Gly, Arg, Lys or His <220> <221> MUTAGEN <222> (123)..(123) <223> Xaa at position 123 is Glu, Arg, Phe or Thr <220> <221> MUTAGEN <222> (144)..(144) <223> Xaa at position 144 is Phe, His, Arg, Pro, Leu, Gln or Glu <220> <221> MUTAGEN <222> (146)..(146) <223> Xaa at position 146 is Arg or Gln <220> <221> MUTAGEN <222> (147)..(147) <223> Xaa ap position 147 is Arg or Gln <220> <221> MUTAGEN <222> (156)..(156) <223> Xaa at position 156 is His, Gly or Ser <220> <221> MUTAGEN <222> (159)..(159) <223> Xaa at position 159 is Ser, Arg, Thr, Tyr, Val or Gly <220> <221> MUTAGEN <222> (16)..(162) <223> Xaa at position 162 is Glu, Leu, Gly or Trp <220> <221> MUTAGEN <222> (163)..(163) <223> Xaa at position 163 is Val, Gly, Arg or Ala <220> <221> MUTAGEN <222> (169)..(169) <223> Xaa at position 169 is Arg, Ser, Leu, Arg or Cys <220> <221> MUTAGEN <222> (170)..(170) <223> Xaa at position 170 is His, Arg or Ser <400> 858 Xaa Xaa Xaa Gly Pro Ala Ser Ser Leu Pro Gln Ser Xaa Leu Leu Xaa 1 5 10 15 Xaa Xaa Glu Gln Val Xaa Lys Xaa Gln Gly Xaa Gly Ala Xaa Leu Gln 20 25 30 Glu Xaa Leu Xaa Ala Thr Tyr Lys Leu Xaa Xaa Xaa Glu Xaa Xaa Val 35 40 45 Xaa Xaa Gly His Ser Xaa Gly Ile Pro Trp Ala Pro Leu Ser Ser Xaa 50 55 60 Pro Ser Xaa Ala Leu Xaa Leu Ala Gly Xaa Leu Ser Gln Leu His Ser 65 70 75 80 Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 85 90 95 Pro Glu Leu Gly Pro Thr Leu Xaa Thr Leu Gln Xaa Asp Val Ala Asp 100 105 110 Phe Ala Xaa Thr Ile Trp Gln Gln Met Glu Xaa Xaa Gly Met Ala Pro 115 120 125 Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Xaa 130 135 140 Gln Xaa Xaa Ala Gly Gly Val Leu Val Ala Ser Xaa Leu Gln Xaa Phe 145 150 155 160 Leu Xaa Xaa Ser Tyr Arg Val Leu Xaa Xaa Leu Ala Gln Pro 165 170 <210> 859 <211> 133 <212> PRT <213> Homo sapiens <220> <221> MUTAGEN <222> (17)..(17) <223> Xaa at position 17 is Ser, Lys, Gly, Asp, Met, Gln, or Arg <220> <221> MUTAGEN <222> (18)..(18) <223> Xaa at position 18 is Asn, His, Leu, Ile, Phe, Arg, or Gln <220> <221> MUTAGEN <222> (19)..(19) <223> Xaa at position 19 is Met, Phe, Ile, Arg, Gly, Ala, or Cys <220> <221> MUTAGEN <222> (20)..(20) <223> Xaa at position 20 is Ile, Cys, Gln, Arg, Pro, or Ala <220> <221> MUTAGEN <222> (21)..(21) <223> Xaa at position 21 is Asp, Phe, Lys, Arg, Ala, Gly, Glu, Asn, Thr, Ser or Val <220> <221> MUTAGEN <222> (22)..(22) <223> Xaa at position 22 is Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val or Gly <220> <221> MUTAGEN <222> (23)..(23) <223> Xaa at position 23 is Ile, Val, Ala, Gly, Trp, Lys, Phe, Leu, Ser, or Arg <220> <221> MUTAGEN <222> (24)..(24) <223> Xaa at position 24 is Ile, Gly, Val, Arg, Ser, Phe, Leu <220> <221> MUTAGEN <222> (25)..(25) <223> Xaa at position 25 is Thr, His, Gly, Gln, Arg, Pro, or Ala <220> <221> MUTAGEN <222> (26)..(26) <223> Xaa at position 26 is His, Thr, Phe, Gly, Arg, Ala, Trp <220> <221> MUTAGEN <222> (27)..(27) <223> Xaa at position 27 is Leu, Gly, Arg, Thr, Ser or Ala <220> <221> MUTAGEN <222> (28)..(28) <223> Xaa at position 28 is Lys, Arg, Leu, Gln, Gly, Pro, Val or Trp <220> <221> MUTAGEN <222> (29)..(29) <223> Xaa at position 29 is Gln, Asn, Leu, Pro, Arg or Val <220> <221> MUTAGEN <222> (30)..(30) <223> Xaa at position 30 is Pro, His, Thr, Gly, Asp, Gln, Ser, Leu, or L... <220> <221> MUTAGEN <222> (31)..(31) <223> Xaa at position 31 is Pro, Asp, Gly, Ala, Arg, Leu or Gln <220> <221> MUTAGEN <222> (32)..(32) <223> Xaa at position 32 is Leu, Val, Arg, Gln, Asn, Gly, Ala, or Glu <220> <221> MUTAGEN <222> (33)..(33) <223> Xaa at position 33 is Pro, Leu, Gln, Ala, Thr or Glu <220> <221> MUTAGEN <222> (34)..(34) <223> Xaa at position 34 is Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile or Met <220> <221> MUTAGEN <222> (35)..(35) <223> Xaa at position 35 is Leu, Ala, Gly, Asn, Pro, Gln or Val <220> <221> MUTAGEN <222> (36)..(36) <223> Xaa at position 36 is Asp, Leu or Val <220> <221> MUTAGEN <222> (37)..(37) <223> Xaa at position 37 is Phe, Ser, Pro, Trp, or Ile <220> <221> MUTAGEN <222> (38)..(38) <223> Xaa at position 38 is Asn, or Ala <220> <221> MUTAGEN <222> (40)..(40) <223> Xaa at position 40 is Leu, Trp or Arg <220> <221> MUTAGEN <222> (41)..(41) <223> Xaa at position 41 is Asn, Cys, Arg, Leu, His, Met, or pro <220> <221> MUTAGEN <222> (42)..(42) <223> Xaa at position 42 is Gly, Asp, Ser, Cys, Asn, Lys, Thr, Leu, Val, Glu, Phe, Tyr, Ile, Met or Ala <220> <221> MUTAGEN <222> (43)..(43) <223> Xaa at position 43 is Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly, or Ser <220> <221> MUTAGEN <222> (44)..(44) <223> Xaa at position 44 is Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala or Pro <220> <221> MUTAGEN <222> (45)..(45) <223> Xaa at position 45 is Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Trp, Asp, Asn, Arg, Ser, Ala, Ile, Glu or His <220> <221> MUTAGEN <222> (46)..(46) <223> Xaa at position 46 is Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val or Gly <220> <221> MUTAGEN <222> (47)..(47) <223> Xaa at position 47 is Ile, Gly, Val, Ser, Arg, Pro, or His <220> <221> MUTAGEN <222> (48)..(48) <223> Xaa atp position 48 is Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val or Asn <220> <221> MUTAGEN <222> (49)..(49) <223> Xaa at position 49 is Met, Arg, Ala, Gly, Pro, Asn, His, or Asp <220> <221> MUTAGEN <222> (50)..(50) <223> Xaa at position 50 is Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met or Gln <220> <221> MUTAGEN <222> (51)..(51) <223> Xaa at position 51 is Asn, Arg, Met, Pro, Ser, Thr, or his <220> <221> MUTAGEN <222> (52)..(52) <223> Xaa at position 52 is Asn, His, Arg, Leu, Gly, Ser or Thr <220> <221> MUTAGEN <222> (53)..(53) <223> Xaa at position 53 is Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser, or M... <220> <221> MUTAGEN <222> (54)..(54) <223> Xaa at position 54 is Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala or Leu <220> <221> MUTAGEN <222> (55)..(55) <223> Xaa at position 55 is Arg, Thr, Val, Ser, Leu, or Gly <220> <221> MUTAGEN <222> (56)..(56) <223> Xaa at position 56 is Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val or Lys <220> <221> MUTAGEN <222> (57)..(57) <223> Xaa at position 57 is Asn or Gly <220> <221> MUTAGEN <222> (58)..(58) <223> Xaa at position 58 is Leu, Ser, Asp, Arg, Gln, Val or Cys <220> <221> MUTAGEN <222> (59)..(59) <223> Xaa at position 59 is Glu, Tyr, His, Leu, Pro, or Arg <220> <221> MUTAGEN <222> (60)..(60) <223> Xaa at position 60 is Ala, Ser, Pro, Tyr, Asn, or Thr <220> <221> MUTAGEN <222> (61)..(61) <223> Xaa at position 61 is Phe, Asn, Glu, Pro, Lys, Arg, or Ser <220> <221> MUTAGEN <222> (62)..(62) <223> Xaa at position 62 is Asn, His, Val, Arg, Pro, Thr, Asp or Ile <220> <221> MUTAGEN <222> (63)..(63) <223> Xaa at position 63 is Arg, Tyr, Trp, Lys, Ser, His, Pro, or Val <220> <221> MUTAGEN <222> (64)..(64) <223> Xaa at position 64 is Ala, Asn, Pro, Ser or Lys <220> <221> MUTAGEN <222> (65)..(65) <223> Xaa at position 65 is Val, Thr, Pro, His, Leu, Phe, or Ser <220> <221> MUTAGEN <222> (66)..(66) <223> Xaa at position 66 is Lys, Ile, Arg, Val, Asn, Glu, or Ser <220> <221> MUTAGEN <222> (67)..(67) <223> Xaa at position 67 is Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro, or His <220> <221> MUTAGEN <222> (68)..(68) <223> Xaa at position 68 is Leu, Val, Trp, Ser, Ile, Phe, Thr, or His <220> <221> MUTAGEN <222> (69)..(69) <223> Xaa at position 69 is Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly or L... <220> <221> MUTAGEN <222> (70)..(70) <223> Xaa at position is Asn, Leu, Val, Trp, pro, or Ala <220> <221> MUTAGEN <222> (71)..(71) <223> Xaa at position 71 is Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp, or Asn <220> <221> MUTAGEN <222> (72)..(72) <223> Xaa at position 72 is Ser, Glu, Met, Ala, His, Asn, Arg, or Asp <220> <221> MUTAGEN <222> (73)..(73) <223> Xaa at position 73 is Ala, Glu, Asp, Leu, Ser, Gly, Thr, or Arg <220> <221> MUTAGEN <222> (74)..(74) <223> Xaa at position 74 is Ile, Met, Thr, Pro, Arg, Gly, Ala <220> <221> MUTAGEN <222> (75)..(75) <223> Xaa at position 75 is Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln, or Leu <220> <221> MUTAGEN <222> (76)..(76) <223> Xaa at position 76 is Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly, or A... <220> <221> MUTAGEN <222> (77)..(77) <223> Xaa at sopition 77 is Ile, Ser, Arg,Thr, or Leu <220> <221> MUTAGEN <222> (78)..(78) <223> Xaa at position 78 is Leu, Ala, Ser, Glu, Phe, Gly, or Arg <220> <221> MUTAGEN <222> (79)..(79) <223> Xaa at sopition 79 is Lys, Thr, Asn, Met, Arg, Ile, Gly, or Asp <220> <221> MUTAGEN <222> (80)..(80) <223> Xaa at sopition 80 is Asn, Trp, Val, Gly, Thr, Leu, Glu, or Arg <220> <221> MUTAGEN <222> (81)..(81) <223> Xaa at sopition 81 is Leu, Gln, Gly, Ala, Trp, Arg, Val, or Lys <220> <221> MUTAGEN <222> (82)..(82) <223> Xaa at sopition 82 is Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met, or Val <220> <221> MUTAGEN <222> (83)..(83) <223> Xaa at sopition 83 is Pro, Ala, Thr, Trp, Arg, or Met <220> <221> MUTAGEN <222> (84)..(84) <223> Xaa at position 84 is Cys, Glu, Gly, Arg, Met, or Val <220> <221> MUTAGEN <222> (85)..(85) <223> Xaa at position 85 is Leu, Asn, Val, or Gln <220> <221> MUTAGEN <222> (86)..(86) <223> Xaa at position 86 is Pro, Cys, Arg, Ala, or Lys <220> <221> MUTAGEN <222> (87)..(87) <223> Xaa at position 87 is Leu, Ser, Trp, or Gly <220> <221> MUTAGEN <222> (88)..(88) <223> Xaa at position 88 is Ala, Lys, Arg, Val, or Trp <220> <221> MUTAGEN <222> (89)..(89) <223> Xaa at position 89 is Thr, Asp, Cys, Leu, Val, Glu, His, Asn, or S... <220> <221> MUTAGEN <222> (90)..(90) <223> Xaa at position 90 is Ala, Pro, Ser, Thr, Gly, Asp, Ile, or Met <220> <221> MUTAGEN <222> (91)..(91) <223> Xaa at position 91 is Ala, Pro, Ser, Thr, Phe, Leu, Asp, or His <220> <221> MUTAGEN <222> (92)..(92) <223> Xaa at position 92 is Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile or Leu <220> <221> MUTAGEN <222> (93)..(93) <223> Xaa at position 93 is Thr, Asp, Ser, Asn, Pro, Ala, Leu, or Arg <220> <221> MUTAGEN <222> (94)..(94) <223> Xaa at position 94 is Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, or Pro <220> <221> MUTAGEN <222> (95)..(95) <223> Xaa at position 95 is His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile or Tyr <220> <221> MUTAGEN <222> (96)..(96) <223> Xaa at position 96 is Pro, Lys, Tyr, Gly, Ile, or Thr <220> <221> MUTAGEN <222> (97)..(97) <223> Xaa at position 97 is Ile, Val, Lys, Ala, or Asn <220> <221> MUTAGEN <222> (98)..(98) <223> Xaa at position 98 is His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr, or Pro <220> <221> MUTAGEN <222> (99)..(99) <223> Xaa at position 99 is Ile, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe, or His <220> <221> MUTAGEN <222> (100)..(100) <223> Xaa at position 100 is Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln, or... <220> <221> MUTAGEN <222> (101)..(101) <223> Xaa at position is Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu, or Gln <220> <221> MUTAGEN <222> (102)..(102) <223> Xaa at position 102 is Gly, Leu, Glu, Lys, Ser, Tyr, or Pro <220> <221> MUTAGEN <222> (103)..(103) <223> Xaa at position 103 is Asp, or Ser <220> <221> MUTAGEN <222> (104)..(104) <223> Xaa at position 104 is Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe, or Gly <220> <221> MUTAGEN <222> (105)..(105) <223> Xaa at postition 105 is Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp, or His <220> <221> MUTAGEN <222> (106)..(106) <223> Xaa at position 106 is Glu, Ser, Ala, Lys, Thr, Ile, Gly, or Pro <220> <221> MUTAGEN <222> (108)..(108) <223> Xaa at position 108 is Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala or Pro <220> <221> MUTAGEN <222> (109)..(109) <223> Xaa at position 109 is Arg, Thr, Pro, Glu, Tyr, Leu, Ser, or Gly <220> <221> MUTAGEN <222> (110)..(110) <223> Xaa at position 110 is Lys, Ala, Asn, Thr, Leu, Arg, Gln, His, Glu, Ser or Trp <220> <221> MUTAGEN <222> (111)..(111) <223> Xaa at position 111 is Leu, Ile, Arg, Asp or Met <220> <221> MUTAGEN <222> (112)..(112) <223> Xaa at position 112 is Thr, Val, Gln, Tyr, Glu, Hsi, Ser or Phe <220> <221> MUTAGEN <222> (113)..(113) <223> Xaa at position 113 is Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val or Asn <220> <221> MUTAGEN <222> (114)..(114) <223> Xaa at position 114 is Tyr, Cys, His, Ser, Trp, Arg or Leu <220> <221> MUTAGEN <222> (115)..(115) <223> Xaa at position 115 is Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp, or Met <220> <221> MUTAGEN <222> (116)..(116) <223> Xaa at position 116 is Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln, or Ile <220> <221> MUTAGEN <222> (117)..(117) <223> Xaa at position 117 is Thr, Ser, Asn, Ile, Trp, Lys, or Pro <220> <221> MUTAGEN <222> (118)..(118) <223> Xaa at position 118 is Leu, Ser, Pro, Ala, Glu, Cys, Asp, or Tyr <220> <221> MUTAGEN <222> (119)..(119) <223> Xaa at position 119 is Glu, Ser, Lys, Pro, Leu, Thr, Tyr, or Arg <220> <221> MUTAGEN <222> (120)..(120) <223> Xaa at position 120 is Asn, Ala, Pro, Leu, His, Val, or Gln <220> <221> MUTAGEN <222> (121)..(121) <223> Xaa at sopition 121 is Ala, Ser, Ile, Asn, Pro, Lys, Asp, or Gly <220> <221> MUTAGEN <222> (122)..(122) <223> Xaa at position 122 is Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr, or Cys <220> <221> MUTAGEN <222> (123)..(123) <223> Xaa at position 123 is Ala, Met, Glu, His, Ser, Pro, Tyr, or Leu <400> 859 Ala Pro Met Thr Gln Thr Thr Ser Leu Lys Thr Ser Trp Val Asn Cys 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 20 25 30 Xaa Xaa Xaa Xaa Xaa Xaa Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 35 40 45 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 50 55 60 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 65 70 75 80 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 85 90 95 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa 100 105 110 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Gln Thr Thr Leu 115 120 125 Ser Leu Ala Ile Phe 130 <210> 860 <211> 153 <212> PRT <213> Homo sapiens <220> <221> MUTAGEN <222> (112)..(112) <223> position 112 is deleted or Leu, Ala, VAl, Ile, Pro, Phe, Trp or Met <220> <221> MUTAGEN <222> (113)..(113) <223> position 113 is deleted or Pro, Phe, Ala, Val, Leu, Ile, Trp or Met <220> <221> MUTAGEN <222> (114)..(114) <223> position 114 is deleted or Pro, Phe, Ala, Val, Leu, Ile, Trp or Met <220> <221> MUTAGEN <222> (115)..(115) <223> positon 115 is deleted or Gln, Gly, Ser, Thr, Tyr, or Asn <400> 860 Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 1 5 10 15 Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gln Cys Pro Glu Val 20 25 30 His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45 Gly Glu Trp Lys Thr Gln Met Glu Glu Thr Lys Ala Gln Asp Ile Leu 50 55 60 Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gln 65 70 75 80 Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gln Leu Ser Gly Gln 85 90 95 Val Arg Leu Leu Leu Gly Ala Leu Gln Ser Leu Leu Gly Thr Gln Xaa 100 105 110 Xaa Xaa Xaa Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala Ile Phe 115 120 125 Leu Ser Phe Gln His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140 Val Gly Gly Ser Thr Leu Cys Val Arg 145 150 <210> 861 <211> 1 <212> PRT <213> Homo sapiens <220> <221> MUTAGEN <222> (1)..(1) <223> where x=(glyglyglyser)n and where n is an integer <400> 861 Xaa <210> 862 <211> 1 <212> PRT <213> Homo sapiens <220> <221> MUTAGEN <222> (1)..(1) <223> where x=(glyglyglyglyser)n and where n is an integer <400> 862 Xaa <210> 863 <211> 1 <212> PRT <213> Homo sapiens <220> <221> MUTAGEN <222> (1)..(1) <223> where x=(glyglyglyglyglyser)n and where n is an integer <400> 863 Xaa <210> 864 <211> 1 <212> PRT <213> Homo sapiens <220> <221> MUTAGEN <222> (1)..(1) <223> where x=(gly n ser)n and where n is an integer <400> 864 Xaa <210> 865 <211> 1 <212> PRT <213> Homo sapiens <220> <221> MUTAGEN <222> (1)..(1) <223> where x=(alaglyser)n and where n is an integer <400> 865 Xaa

Claims

다음 식의 아미노산 서열로 구성되는 것을 특징으로 하는 조혈 단백질:

R₁-L₁-R₂, R₂-L₁-R₁, R₁-R₂, 또는 R₂-R₁

상기 식에서 R₁ 은 다음 식의 변형된 flt-3 리간드 아미노산 서열로 구성되는 사람 flt-3 수용체 아고니스트 폴리펩티드이다.

여기서 1-7 아미노산은 상기 flt-3 수용체 아고니스트 폴리펩티드의 C-말단으로부터 선택적으로 결실되고;

N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

28-29 42-43 93-94

29-30 64-65 94-95

30-31 65-66 95-96

31-32 66-67 96-97

32-33 86-87 97-98

34-35 87-88 98-99

36-37 88-89 9 9-100

37-38 89-90 100-101

38-39 90-91 101-102

39-40 91-92 102-103

40-41 92-93

41-42

또한, R₂는 독립적으로 다음의 (I) 내지 (VIII)로 구성되는 군으로부터 선택된다.

(I) 다음 식의 변형된 EPO 아미노산 서열로 구성되는 사람 EPO 수용체 아고니스트 폴리펩티드:

여기서 N-말단으로부터의 1-6 아미노산, 또는 C-말단으로부터의 1-5 아미노산, 또는 N-말단으로부터의 1-6 아미노산 및 C-말단으로부터의 1-5 아미노산 모두가 선택적으로 상기 EPO 수용체 아고니스트 폴리펩티드로부터 결실되고;

N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

23-24 7-48 109-110

24-25 48-49 110-111

25-26 49-50 111-112

26-27 50-51 112-113

27-28 51-52 113-114

28-29 52-53 114-115

29-30 53-54 115-116

30-31 54-55 116-117

31-32 55-56 117-118

32-33 56-57 118-119

33-34 57-58 119-120

34-35 77-78 120-121

35-36 78-79 121-122

36-37 79-80 122-123

37-38 80-81 123-124

38-39 81-82 124-125

39-40 82-83 125-126

40-41 84-85 126-127

41-42 85-86 127-128

42-43 86-87 128-129

43-44 87-88 129-130

44-45 88-89 130-131

45-46 108-109 131-132

46-47

(II) 다음 식의 변형된 간세포인자 아미노산 서열로 구성되는 사람 간세포인자 수용체 아고니스트 폴리펩티드:

여기서 1-23 아미노산은 상기 간세포인자 수용체 아고니스트 폴리펩티드의 C-말단으로부터 선택적으로 결실되고;

N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

23-24 39-40 96-97

24-25 40-41 97-98

25-26 64-65 98-99

26-27 65-66 99-100

27-28 66-67 100-101

28-29 67-68 101-102

29-30 68-69 102-103

30-31 69-70 103-104

31-32 70-71 104-105

32-33 89-90 105-106

33-34 90-91 106-107

34-35 91-92 107-108

35-36 92-93 108-109

36-37 93-94 109-110

37-38 94-95 110-111

38-39 95-96

(III) 다음 식의 변형된 flt-3 리간드 아미노산 서열로 구성되는 사람 flt-3 수용체 아고니스트 폴리펩티드:

여기서 1-7 아미노산은 상기 flt-3 수용체 아고니스트 폴리펩티드의 C-말단으로부터 선택적으로 결실되고;

N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

28-29 42-43 93-94

29-30 64-65 94-95

30-31 65-66 95-96

31-32 66-67 96-97

32-33 86-87 97-98

34-35 87-88 98-99

36-37 88-89 9 9-100

37-38 89-90 100-101

38-39 90-91 101-102

39-40 91-92 102-103

40-41 92-93

41-42

(IV) 다음 식의 변형된 사람 G-CSF 아미노산 서열로 구성되는 폴리펩티드:

여기서 위치 1의 Xaa는 Thr, Ser, Arg, Tyr 또는 Gly;

위치 2의 Xaa는 Pro 또는 Leu;

위치 3의 Xaa는 Leu, Arg, Tyr 또는 Ser;

위치 13의 Xaa는 Phe, Ser, His, Thr 또는 Pro;

위치 16의 Xaa는 Lys, Pro, Ser, Thr 또는 His;

위치 17의 Xaa는 Cys, Ser, Gly, Ala, Ile, Tyr 또는 Arg;

위치 18의 Xaa는 Leu, Thr, Pro, His, Ile 또는 Cys;

위치 22의 Xaa는 Arg, Tyr, Ser, Thr 또는 Ala;

위치 24의 Xaa는 Ile, Pro, Tyr 또는 Leu;

위치 27의 Xaa는 Asp 또는 Gly;

위치 30의 Xaa는 Ala, Ile, Leu 또는 Gly;

위치 34의 Xaa는 Lys 또는 Ser;

위치 36의 Xaa는 Cys 또는 Ser;

위치 42의 Xaa는 Cys 또는 Ser;

위치 43의 Xaa는 His, Thr, Gly, Val, Lys, Trp, Ala, Arg, Cys 또는 Leu;

위치 44의 Xaa는 Pro, Gly, Arg, Asp, Val, Ala, His, Trp, Gln 또는 Thr;

위치 46의 Xaa는 Glu, Arg, Phe, Arg, Ile 또는 Ala;

위치 47의 Xaa는 Leu 또는 Thr;

위치 49의 Xaa는 Leu, Phe, Arg 또는 Ser;

위치 50의 Xaa는 Leu, Ile, His, Pro 또는 Tyr;

위치 54의 Xaa는 Leu 또는 His;

위치 64의 Xaa는 Cys 또는 Ser;

위치 67의 Xaa는 Gln, Lys, Leu 또는 Cys;

위치 70의 Xaa는 Gln, Pro, Leu, Arg 또는 Ser;

위치 74의 Xaa는 Cys 또는 Ser;

위치 104의 Xaa는 Asp, Gly 또는 Val;

위치 108의 Xaa는 Leu, Ala, Val, Arg, Trp, Gln 또는 Gly;

위치 115의 Xaa는 Thr, His, Leu 또는 Ala;

위치 120의 Xaa는 Gln, Gly, Arg, Lys 또는 His;

위치 123의 Xaa는 Glu, Arg, Phe 또는 Thr;

위치 144의 Xaa는 Phe, His, Arg, Pro, Leu, Gln 또는 Glu;

위치 146의 Xaa는 Arg 또는 Gln;

위치 147의 Xaa는 Arg 또는 Gln;

위치 156의 Xaa는 His, Gly 또는 Ser;

위치 159의 Xaa는 Ser, Arg, Thr, Tyr, Val 또는 Gly;

위치 162의 Xaa는 Glu, Leu, Gly 또는 Trp;

위치 163의 Xaa는 Val, Gly, Arg 또는 Ala;

위치 169의 Xaa는 Arg, Ser, Leu, Arg 또는 Cys;

위치 170의 Xaa는 His, Arg 또는 Ser이고;

여기서 N-말단으로부터의 1-11 아미노산, 또는 C-말단으로부터의 1-5 아미노산, 또는 N-말단으로부터의 1-11 아미노산 및 C-말단으로부터의 1-5 아미노산 모두가 상기 변형된 사람 G-CSF 아미노산 서열로부터 선택적으로 결실되고;

N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

38-39 62-63 123-124

39-40 63-64 124-125

40-41 64-65 125-126

41-42 65-66 126-127

42-43 66-67 128-129

43-44 67-68 128-129

45-46 68-69 129-130

48-49 69-70 130-131

49-50 70-71 131-132

52-53 71-72 132-133

53-54 91-92 133-134

54-55 92-93 134-135

55-56 93-94 135-136

56-57 94-95 136-137

57-58 95-96 137-138

58-59 96-97 138-139

59-60 97-98 139-140

60-61 98-99 140-141

61-62 99-100 141-142

또는 142-143

(V) 다음 식의 변형된 사람 IL-3 아미노산 서열로 구성되는 폴리펩티드:

여기서 위치 17의 Xaa는 Ser, Lys, Gly, Asp, Met, Gln 또는 Arg;

위치 18의 Xaa는 Asn, His, Leu, Ile, Phe, Arg 또는 Gln;

위치 19의 Xaa는 Met, Phe, Ile, Arg, Gly, Ala 또는 Cys;

위치 20의 Xaa는 Ile, Cys, Gln, Glu, Arg, Pro 또는 Ala;

위치 21의 Xaa는 Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser 또는 Val;

위치 22의 Xaa는 Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val 또는 Gly;

위치 23의 Xaa는 Ile, Val, Ala, Gly, Trp, Lys, Phe, Leu, Ser 또는 Arg;

위치 24의 Xaa는 Ile, Gly, Val, Arg, Ser, Phe 또는 Leu;

위치 25의 Xaa는 Thr, His, Gly, Gln, Arg, Pro 또는 Ala;

위치 26의 Xaa는 His, Thr, Phe, Gly, Arg, Ala 또는 Trp;

위치 27의 Xaa는 Leu, Gly, Arg, Thr, Ser 또는 Ala;

위치 28의 Xaa는 Lys, Arg, Leu, Gln, Gly, Pro, Val 또는 Trp;

위치 29의 Xaa는 Gln, Asn, Leu, Pro, Arg 또는 Val;

위치 30의 Xaa는 Pro, His, Thr, Gly, Asp, Gln, Ser, Leu 또는 Lys;

위치 31의 Xaa는 Pro, Asp, Gly, Ala, Arg, Leu 또는 Gln;

위치 32의 Xaa는 Leu, Val, Arg, Gln, Asn, Gly, Ala 또는 Glu;

위치 33의 Xaa는 Pro, Leu, Gln, Ala, Thr 또는 Glu;

위치 34의 Xaa는 Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile 또는 Met;

위치 35의 Xaa는 Leu, Ala, Gly, Asn, Pro, Gln 또는 Val;

위치 36의 Xaa는 Asp, Leu 또는 Val;

위치 37의 Xaa는 Phe, Ser, Pro, Trp 또는 Ile;

위치 38의 Xaa는 Asn 또는 Ala;

위치 40의 Xaa는 Leu, Trp 또는 Arg;

위치 41의 Xaa는 Asn, Cys, Arg, Leu, His, Met 또는 Pro;

위치 42의 Xaa는 Gly, Asp, Ser, Cys, Asn, Lys, Thr, Leu, Val, Glu, Phe, Tyr, Ile, Met 또는 Ala;

위치 43의 Xaa는 Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly 또는 Ser;

위치 44의 Xaa는 Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala 또는 Pro;

위치 45의 Xaa는 Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Trp, Asp, Asn, Arg, Ser, Ala, Ile, Glu 또는 His;

위치 46의 Xaa는 Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val 또는 Gly;

위치 47의 Xaa는 Ile, Gly, Val, Ser, Arg, Pro 또는 His;

위치 48의 Xaa는 Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val 또는 Asn;

위치 49의 Xaa는 Met, Arg, Ala, Gly, Pro, Asn, His 또는 Asp;

위치 50의 Xaa는 Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met 또는 Gln;

위치 51의 Xaa는 Asn, Arg, Met, Pro, Ser, Thr 또는 His;

위치 52의 Xaa는 Asn, His, Arg, Leu, Gly, Ser 또는 Thr;

위치 53의 Xaa는 Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser 또는 Met;

위치 54의 Xaa는 Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala 또는 Leu;

위치 55의 Xaa는 Arg, Thr, Val, Ser, Leu 또는 Gly;

위치 56의 Xaa는 Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val 또는 Lys;

위치 57의 Xaa는 Asn 또는 Gly;

위치 58의 Xaa는 Leu, Ser, Asp, Arg, Gln, Val 또는 Cys;

위치 59의 Xaa는 Glu Tyr, His, Leu, Pro 또는 Arg;

위치 60의 Xaa는 Ala, Ser, Pro, Tyr, Asn 또는 Thr;

위치 61의 Xaa는 Phe, Asn, Glu, Pro, Lys, Arg 또는 Ser;

위치 62의 Xaa는 Asn, His, Val, Arg, Pro, Thr, Asp 또는 Ile;

위치 63의 Xaa는 Arg, Tyr, Trp, Lys, Ser, His, Pro 또는 Val;

위치 64의 Xaa는 Ala, Asn, Pro, Ser 또는 Lys;

위치 65의 Xaa는 Val, Thr, Pro, His, Leu, Phe 또는 Ser;

위치 66의 Xaa는 Lys, Ile, Arg, Val, Asn, Glu 또는 Ser;

위치 67의 Xaa는 Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro 또는 His;

위치 68의 Xaa는 Leu, Val, Trp, Ser, Ile, Phe, Thr 또는 His;

위치 69의 Xaa는 Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly 또는 Leu;

위치 70의 Xaa는 Asn, Leu, Val, Trp, Pro 또는 Ala;

위치 71의 Xaa는 Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp 또는 Asn;

위치 72의 Xaa는 Ser, Glu, Met, Ala, His, Asn, Arg 또는 Asp;

위치 73의 Xaa는 Ala, Glu, Asp, Leu, Ser, Gly, Thr 또는 Arg;

위치 74의 Xaa는 Ile, Met, Thr, Pro, Arg, Gly 또는 Ala;

위치 75의 Xaa는 Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln 또는 Leu;

위치 76의 Xaa는 Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly 또는 Asp;

위치 77의 Xaa는 Ile, Ser, Arg, Thr 또는 Leu;

위치 78의 Xaa는 Leu, Ala, Ser, Glu, Phe, Gly 또는 Arg;

위치 79의 Xaa는 Lys, Thr, Asn, Met, Arg, Ile, Gly 또는 Asp;

위치 80의 Xaa는 Asn, Trp, Val, Gly, Thr, Leu, Glu 또는 Arg;

위치 81의 Xaa는 Leu, Gln, Gly, Ala, Trp, Arg, Val 또는 Lys;

위치 82의 Xaa는 Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met 또는 Val;

위치 83의 Xaa는 Pro, Ala, Thr, Trp, Arg 또는 Met;

위치 84의 Xaa는 Cys, Glu, Gly, Arg, Met 또는 Val;

위치 85의 Xaa는 Leu, Asn, Val 또는 Gln;

위치 86의 Xaa는 Pro, Cys, Arg, Ala 또는 Lys;

위치 87의 Xaa는 Leu, Ser, Trp 또는 Gly;

위치 88의 Xaa는 Ala, Lys, Arg, Val 또는 Trp;

위치 89의 Xaa는 Thr, Asp, Cys, Leu, Val, Glu, His, Asn 또는 Ser;

위치 90의 Xaa는 Ala, Pro, Ser, Thr, Gly, Asp, Ile 또는 Met;

위치 91의 Xaa는 Ala, Pro, Ser, Thr, Phe, Leu, Asp 또는 His;

위치 92의 Xaa는 Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile 또는 Leu;

위치 93의 Xaa는 Thr, Asp, Ser, Asn, Pro, Ala, Leu 또는 Arg;

위치 94의 Xaa는 Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala 또는 Pro;

위치 95의 Xaa는 His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile 또는 Tyr;

위치 96의 Xaa는 Pro, Lys, Tyr, Gly, Ile 또는 Thr;

위치 97의 Xaa는 Ile, Val, Lys, Ala 또는 Asn;

위치 98의 Xaa는 His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr 또는 Pro;

위치 99의 Xaa는 Ile, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe 또는 His;

위치 100의 Xaa는 Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln 또는 Pro;

위치 101의 Xaa는 Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu 또는 Gln;

위치 102의 Xaa는 Gly, Leu, Glu, Lys, Ser, Tyr 또는 Pro;

위치 103의 Xaa는 Asp 또는 Ser;

위치 104의 Xaa는 Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe 또는 Gly;

위치 105의 Xaa는 Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp 또는 His;

위치 106의 Xaa는 Glu, Ser, Ala, Lys, Thr, Ile, Gly 또는 Pro;

위치 108의 Xaa는 Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala 또는 Pro;

위치 109의 Xaa는 Arg, Thr, Pro, Glu, Tyr, Leu, Ser 또는 Gly;

위치 110의 Xaa는 Lys, Ala, Asn, Thr, Leu, Arg, Gln, His, Glu, Ser 또는 Trp;

위치 111의 Xaa는 Leu, Ile, Arg, Asp 또는 Met;

위치 112의 Xaa는 Thr, Val, Gln, Tyr, Glu, His, Ser 또는 Phe;

위치 113의 Xaa는 Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val 또는 Asn;

위치 114의 Xaa는 Tyr, Cys, His, Ser, Trp, Arg 또는 Leu;

위치 115의 Xaa는 Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp 또는 Met;

위치 116의 Xaa는 Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln 또는 Ile;

위치 117의 Xaa는 Thr, Ser, Asn, Ile, Trp, Lys 또는 Pro;

위치 118의 Xaa는 Leu, Ser, Pro, Ala, Glu, Cys, Asp 또는 Tyr;

위치 119의 Xaa는 Glu, Ser, Lys, Pro, Leu, Thr, Tyr 또는 Arg;

위치 120의 Xaa는 Asn, Ala, Pro, Leu, His, Val 또는 Gln;

위치 121의 Xaa는 Ala, Ser, Ile, Asn, Pro, Lys, Asp 또는 Gly;

위치 122의 Xaa는 Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr 또는 Cys;

위치 123의 Xaa는 Ala, Met, Glu, His, Ser, Pro, Tyr 또는 Leu이고;

여기서 N-말단으로부터의 1-14 아미노산, 또는 C-말단으로부터의 1-15 아미노산, 또는 N-말단으로부터의 1-14 아미노산 및 C-말단으로부터의 1-15 아미노산 모두가 상기 변형된 사람 IL-3 아미노산 서열의 C-말단으로부터 선택적으로 결실되고; Xaa로 나타낸 아미노산 중 0 내지 44개는 천연 (1-133) 사람 인터루킨-3의 대응 아미노산과 상이하고;

N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

26-27 9-50 83-84

27-28 50-51 84-85

28-29 51-52 85-86

29-30 52-53 86-87

30-31 53-54 87-88

31-32 54-55 88-89

32-33 64-65 89-90

33-34 65-66 90-91

34-35 66-67 91-92

35-36 67-68 92-93

36-37 68-69 97-98

37-38 69-70 98-99

38-39 70-71 99-100

39-40 71-72 100-101

40-41 72-73 101-102

41-42 82-83 102-103

또는 103-104

(VI) 다음 식의 변형된 사람 c-mpl 리간드 아미노산 서열로 구성되는 폴리펩티드:

여기서 위치 112의 Xaa는 결실되거나 또는 Leu, Ala, Val, Ile, Pro, Phe, Trp 또는 Met;

위치 113의 Xaa는 결실되거나 또는 Pro, Phe, Ala, Val, Leu, Ile, Trp 또는 Met;

위치 114의 Xaa는 결실되거나 또는 Pro, Phe, Ala, Val, Leu, Ile, Trp 또는 Met;

위치 115의 Xaa는 결실되거나 또는 Gln, Gly, Ser, Thr, Tyr 또는 Asn이고;

N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

26-27 51-52 108-109

27-28 52-53 109-110

28-29 53-54 110-111

29-30 54-55 111-112

30-31 55-56 112-113

32-33 56-57 113-114

33-34 57-58 114-115

34-35 58-59 115-116

36-37 59-60 116-117

37-38 78-79 117-118

38-39 79-80 118-119

40-41 80-81 119-120

41-42 81-82 120-121

42-43 82-83 121-122

43-44 83-84 122-123

44-45 84-85 123-124

46-47 85-86 124-125

47-48 86-87 125-126

48-49 87-88 126-127

50-51 88-89 또는 127-128

(VII) 다음 식의 변형된 사람 IL-3 아미노산 서열로 구성되는 폴리펩티드:

여기서 위치 17의 Xaa는 Ser, Lys, Gly, Asp, Met, Gln 또는 Arg;

위치 18의 Xaa는 Asn, His, Leu, Ile, Phe, Arg 또는 Gln;

위치 19의 Xaa는 Met, Phe, Ile, Arg, Gly, Ala 또는 Cys;

위치 20의 Xaa는 Ile, Cys, Gln, Glu, Arg, Pro 또는 Ala;

위치 21의 Xaa는 Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser 또는 Val;

위치 22의 Xaa는 Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val 또는 Gly;

위치 23의 Xaa는 Ile, Val, Ala, Gly, Trp, Lys, Phe, Leu, Ser 또는 Arg;

위치 24의 Xaa는 Ile, Gly, Val, Arg, Ser, Phe 또는 Leu;

위치 25의 Xaa는 Thr, His, Gly, Gln, Arg, Pro 또는 Ala;

위치 26의 Xaa는 His, Thr, Phe, Gly, Arg, Ala 또는 Trp;

위치 27의 Xaa는 Leu, Gly, Arg, Thr, Ser 또는 Ala;

위치 28의 Xaa는 Lys, Arg, Leu, Gln, Gly, Pro, Val 또는 Trp;

위치 29의 Xaa는 Gln, Asn, Leu, Pro, Arg 또는 Val;

위치 30의 Xaa는 Pro, His, Thr, Gly, Asp, Gln, Ser, Leu 또는 Lys;

위치 31의 Xaa는 Pro, Asp, Gly, Ala, Arg, Leu 또는 Gln;

위치 32의 Xaa는 Leu, Val, Arg, Gln, Asn, Gly, Ala 또는 Glu;

위치 33의 Xaa는 Pro, Leu, Gln, Ala, Thr 또는 Glu;

위치 34의 Xaa는 Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile 또는 Met;

위치 35의 Xaa는 Leu, Ala, Gly, Asn, Pro, Gln 또는 Val;

위치 36의 Xaa는 Asp, Leu 또는 Val;

위치 37의 Xaa는 Phe, Ser, Pro, Trp 또는 Ile;

위치 38의 Xaa는 Asn 또는 Ala;

위치 40의 Xaa는 Leu, Trp 또는 Arg;

위치 41의 Xaa는 Asn, Cys, Arg, Leu, His, Met 또는 Pro;

위치 42의 Xaa는 Gly, Asp, Ser, Cys, Asn, Lys, Thr, Leu, Val, Glu, Phe, Tyr, Ile, Met 또는 Ala;

위치 43의 Xaa는 Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly 또는 Ser;

위치 44의 Xaa는 Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala 또는 Pro;

위치 45의 Xaa는 Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Trp, Asp, Asn, Arg, Ser, Ala, Ile, Glu 또는 His;

위치 46의 Xaa는 Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val 또는 Gly;

위치 47의 Xaa는 Ile, Gly, Val, Ser, Arg, Pro 또는 His;

위치 48의 Xaa는 Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val 또는 Asn;

위치 49의 Xaa는 Met, Arg, Ala, Gly, Pro, Asn, His 또는 Asp;

위치 50의 Xaa는 Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met 또는 Gln;

위치 51의 Xaa는 Asn, Arg, Met, Pro, Ser, Thr 또는 His;

위치 52의 Xaa는 Asn, His, Arg, Leu, Gly, Ser 또는 Thr;

위치 53의 Xaa는 Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser 또는 Met;

위치 54의 Xaa는 Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala 또는 Leu;

위치 55의 Xaa는 Arg, Thr, Val, Ser, Leu 또는 Gly;

위치 56의 Xaa는 Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val 또는 Lys;

위치 57의 Xaa는 Asn 또는 Gly;

위치 58의 Xaa는 Leu, Ser, Asp, Arg, Gln, Val 또는 Cys;

위치 59의 Xaa는 Glu Tyr, His, Leu, Pro 또는 Arg;

위치 60의 Xaa는 Ala, Ser, Pro, Tyr, Asn 또는 Thr;

위치 61의 Xaa는 Phe, Asn, Glu, Pro, Lys, Arg 또는 Ser;

위치 62의 Xaa는 Asn, His, Val, Arg, Pro, Thr, Asp 또는 Ile;

위치 63의 Xaa는 Arg, Tyr, Trp, Lys, Ser, His, Pro 또는 Val;

위치 64의 Xaa는 Ala, Asn, Pro, Ser 또는 Lys;

위치 65의 Xaa는 Val, Thr, Pro, His, Leu, Phe 또는 Ser;

위치 66의 Xaa는 Lys, Ile, Arg, Val, Asn, Glu 또는 Ser;

위치 67의 Xaa는 Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro 또는 His;

위치 68의 Xaa는 Leu, Val, Trp, Ser, Ile, Phe, Thr 또는 His;

위치 69의 Xaa는 Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly 또는 Leu;

위치 70의 Xaa는 Asn, Leu, Val, Trp, Pro 또는 Ala;

위치 71의 Xaa는 Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp 또는 Asn;

위치 72의 Xaa는 Ser, Glu, Met, Ala, His, Asn, Arg 또는 Asp;

위치 73의 Xaa는 Ala, Glu, Asp, Leu, Ser, Gly, Thr 또는 Arg;

위치 74의 Xaa는 Ile, Met, Thr, Pro, Arg, Gly 또는 Ala;

위치 75의 Xaa는 Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln 또는 Leu;

위치 76의 Xaa는 Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly 또는 Asp;

위치 77의 Xaa는 Ile, Ser, Arg, Thr 또는 Leu;

위치 78의 Xaa는 Leu, Ala, Ser, Glu, Phe, Gly 또는 Arg;

위치 79의 Xaa는 Lys, Thr, Asn, Met, Arg, Ile, Gly 또는 Asp;

위치 80의 Xaa는 Asn, Trp, Val, Gly, Thr, Leu, Glu 또는 Arg;

위치 81의 Xaa는 Leu, Gln, Gly, Ala, Trp, Arg, Val 또는 Lys;

위치 82의 Xaa는 Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met 또는 Val;

위치 83의 Xaa는 Pro, Ala, Thr, Trp, Arg 또는 Met;

위치 84의 Xaa는 Cys, Glu, Gly, Arg, Met 또는 Val;

위치 85의 Xaa는 Leu, Asn, Val 또는 Gln;

위치 86의 Xaa는 Pro, Cys, Arg, Ala 또는 Lys;

위치 87의 Xaa는 Leu, Ser, Trp 또는 Gly;

위치 88의 Xaa는 Ala, Lys, Arg, Val 또는 Trp;

위치 89의 Xaa는 Thr, Asp, Cys, Leu, Val, Glu, His, Asn 또는 Ser;

위치 90의 Xaa는 Ala, Pro, Ser, Thr, Gly, Asp, Ile 또는 Met;

위치 91의 Xaa는 Ala, Pro, Ser, Thr, Phe, Leu, Asp 또는 His;

위치 92의 Xaa는 Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile 또는 Leu;

위치 93의 Xaa는 Thr, Asp, Ser, Asn, Pro, Ala, Leu 또는 Arg;

위치 94의 Xaa는 Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala 또는 Pro;

위치 95의 Xaa는 His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile 또는 Tyr;

위치 96의 Xaa는 Pro, Lys, Tyr, Gly, Ile 또는 Thr;

위치 97의 Xaa는 Ile, Val, Lys, Ala 또는 Asn;

위치 98의 Xaa는 His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr 또는 Pro;

위치 99의 Xaa는 le, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe 또는 His;

위치 100의 Xaa는 Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln 또는 Pro;

위치 101의 Xaa는 Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu 또는 Gln;

위치 102의 Xaa는 Gly, Leu, Glu, Lys, Ser, Tyr 또는 Pro;

위치 103의 Xaa는 Asp 또는 Ser;

위치 104의 Xaa는 Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe 또는 Gly;

위치 105의 Xaa는 Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp 또는 His;

위치 106의 Xaa는 Glu, Ser, Ala, Lys, Thr, Ile, Gly 또는 Pro;

위치 108의 Xaa는 Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala 또는 Pro;

위치 109의 Xaa는 Arg, Thr, Pro, Glu, Tyr, Leu, Ser 또는 Gly;

위치 110의 Xaa는 Lys, Ala, Asn, Thr, Leu, Arg, Gln, His, Glu, Ser 또는 Trp;

위치 111의 Xaa는 Leu, Ile, Arg, Asp 또는 Met;

위치 112의 Xaa는 Thr, Val, Gln, Tyr, Glu, His, Ser 또는 Phe;

위치 113의 Xaa는 Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val 또는 Asn;

위치 114의 Xaa는 Tyr, Cys, His, Ser, Trp, Arg 또는 Leu;

위치 115의 Xaa는 Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp 또는 Met;

위치 116의 Xaa는 Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln 또는 Ile;

위치 117의 Xaa는 Thr, Ser, Asn, Ile, Trp, Lys 또는 Pro;

위치 118의 Xaa는 Leu, Ser, Pro, Ala, Glu, Cys, Asp 또는 Tyr;

위치 119의 Xaa는 Glu, Ser, Lys, Pro, Leu, Thr, Tyr 또는 Arg;

위치 120의 Xaa는 Asn, Ala, Pro, Leu, His, Val 또는 Gln;

위치 121의 Xaa는 Ala, Ser, Ile, Asn, Pro, Lys, Asp 또는 Gly;

위치 122의 Xaa는 Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr 또는 Cys;

위치 123의 Xaa는 Ala, Met, Glu, His, Ser, Pro, Tyr 또는 Leu이고;

N-말단으로부터의 1-14 아미노산, 또는 C-말단으로부터의 1-15 아미노산, 또는 N-말단으로부터의 1-14 아미노산 및 C-말단으로부터의 1-15 아미노산은 변형된 사람 IL-3 아미노산 서열의 C-말단으로부터 선택적으로 결실되고; Xaa로 나타낸 아미노산 중 1 내지 44개는 천연 (1-133) 사람 인터루킨-3의 대응 아미노산과 상이하다.

(VIII) 콜로니자극인자, 시토카인, 림포카인, 인터루킨 및 조혈성장인자로 구성되는 군으로부터 선택된 인자.

또한 상기 식에서 L₁은 R₁을 R₂에 연결할 수 있는 링커이고;

상기 조혈 단백질 바로 앞에 선택적으로 (-1 위치의 메티오닌), (-1 위치의 알라닌) 또는 (-2 위치의 메티오닌, -1 위치의 알라닌)이 올 수 있다.
다음 식의 아미노산 서열로 구성되는 것을 특징으로 하는 조혈 단백질:

R₁-L₁-R₂, R₂-L₁-R₁, R₁-R₂, 또는 R₂-R₁

상기 식에서 R₁ 은 다음 식의 변형된 flt-3 리간드 아미노산 서열로 구성되는 사람 flt-3 수용체 아고니스트 폴리펩티드이다.

여기서 1-7 아미노산은 상기 flt-3 수용체 아고니스트 폴리펩티드의 C-말단으로부터 선택적으로 결실되고;

N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

28-29 42-43 93-94

29-30 64-65 94-95

30-31 65-66 95-96

31-32 66-67 96-97

32-33 86-87 97-98

34-35 87-88 98-99

36-37 88-89 9 9-100

37-38 89-90 100-101

38-39 90-91 101-102

39-40 91-92 102-103

40-41 92-93

41-42

또한, R₂는 독립적으로 다음의 (I) 내지 (V)로 구성되는 군으로부터 선택된다.

(I) 다음 식의 변형된 EPO 아미노산 서열로 구성되는 사람 EPO 수용체 아고니스트 폴리펩티드:

여기서 N-말단으로부터의 1-6 아미노산, 또는 C-말단으로부터의 1-5 아미노산, 또는 N-말단으로부터의 1-6 아미노산 및 C-말단으로부터의 1-5 아미노산 모두는 선택적으로 상기 EPO 수용체 아고니스트 폴리펩티드로부터 결실되고;

N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

23-24 7-48 109-110

24-25 48-49 110-111

25-26 49-50 111-112

26-27 50-51 112-113

27-28 51-52 113-114

28-29 52-53 114-115

29-30 53-54 115-116

30-31 54-55 116-117

31-32 55-56 117-118

32-33 56-57 118-119

33-34 57-58 119-120

34-35 77-78 120-121

35-36 78-79 121-122

36-37 79-80 122-123

37-38 80-81 123-124

38-39 81-82 124-125

39-40 82-83 125-126

40-41 84-85 126-127

41-42 85-86 127-128

42-43 86-87 128-129

43-44 87-88 129-130

44-45 88-89 130-131

45-46 108-109 131-132

46-47

(II) 다음 식의 변형된 간세포인자 아미노산 서열로 구성되는 사람 간세포인자 수용체 아고니스트 폴리펩티드:

여기서 1-23 아미노산은 상기 간세포인자 수용체 아고니스트 폴리펩티드의 C-말단으로부터 선택적으로 결실되고;

N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

23-24 39-40 96-97

24-25 40-41 97-98

25-26 64-65 98-99

26-27 65-66 99-100

27-28 66-67 100-101

28-29 67-68 101-102

29-30 68-69 102-103

30-31 69-70 103-104

31-32 70-71 104-105

32-33 89-90 105-106

33-34 90-91 106-107

34-35 91-92 107-108

35-36 92-93 108-109

36-37 93-94 109-110

37-38 94-95 110-111

38-39 95-96

(III) 다음 식의 변형된 flt-3 리간드 아미노산 서열로 구성되는 사람 flt-3 수용체 아고니스트 폴리펩티드:

여기서 1-7 아미노산은 상기 flt-3 수용체 아고니스트 폴리펩티드의 C-말단으로부터 선택적으로 결실되고;

N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

28-29 42-43 93-94

29-30 64-65 94-95

30-31 65-66 95-96

31-32 66-67 96-97

32-33 86-87 97-98

34-35 87-88 98-99

36-37 88-89 9 9-100

37-38 89-90 100-101

38-39 90-91 101-102

39-40 91-92 102-103

40-41 92-93

41-42

(IV) 다음 식의 변형된 사람 IL-3 아미노산 서열로 구성되는 폴리펩티드:

여기서 위치 17의 Xaa는 Ser, Lys, Gly, Asp, Met, Gln 또는 Arg;

위치 18의 Xaa는 Asn, His, Leu, Ile, Phe, Arg 또는 Gln;

위치 19의 Xaa는 Met, Phe, Ile, Arg, Gly, Ala 또는 Cys;

위치 20의 Xaa는 Ile, Cys, Gln, Glu, Arg, Pro 또는 Ala;

위치 21의 Xaa는 Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser 또는 Val;

위치 22의 Xaa는 Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val 또는 Gly;

위치 23의 Xaa는 Ile, Val, Ala, Gly, Trp, Lys, Phe, Leu, Ser 또는 Arg;

위치 24의 Xaa는 Ile, Gly, Val, Arg, Ser, Phe 또는 Leu;

위치 25의 Xaa는 Thr, His, Gly, Gln, Arg, Pro 또는 Ala;

위치 26의 Xaa는 His, Thr, Phe, Gly, Arg, Ala 또는 Trp;

위치 27의 Xaa는 Leu, Gly, Arg, Thr, Ser 또는 Ala;

위치 28의 Xaa는 Lys, Arg, Leu, Gln, Gly, Pro, Val 또는 Trp;

위치 29의 Xaa는 Gln, Asn, Leu, Pro, Arg 또는 Val;

위치 30의 Xaa는 Pro, His, Thr, Gly, Asp, Gln, Ser, Leu 또는 Lys;

위치 31의 Xaa는 Pro, Asp, Gly, Ala, Arg, Leu 또는 Gln;

위치 32의 Xaa는 Leu, Val, Arg, Gln, Asn, Gly, Ala 또는 Glu;

위치 33의 Xaa는 Pro, Leu, Gln, Ala, Thr 또는 Glu;

위치 34의 Xaa는 Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile 또는 Met;

위치 35의 Xaa는 Leu, Ala, Gly, Asn, Pro, Gln 또는 Val;

위치 36의 Xaa는 Asp, Leu 또는 Val;

위치 37의 Xaa는 Phe, Ser, Pro, Trp 또는 Ile;

위치 38의 Xaa는 Asn 또는 Ala;

위치 40의 Xaa는 Leu, Trp 또는 Arg;

위치 41의 Xaa는 Asn, Cys, Arg, Leu, His, Met 또는 Pro;

위치 42의 Xaa는 Gly, Asp, Ser, Cys, Asn, Lys, Thr, Leu, Val, Glu, Phe, Tyr, Ile, Met 또는 Ala;

위치 43의 Xaa는 Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly 또는 Ser;

위치 44의 Xaa는 Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala 또는 Pro;

위치 45의 Xaa는 Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Trp, Asp, Asn, Arg, Ser, Ala, Ile, Glu 또는 His;

위치 46의 Xaa는 Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val 또는 Gly;

위치 47의 Xaa는 Ile, Gly, Val, Ser, Arg, Pro 또는 His;

위치 48의 Xaa는 Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val 또는 Asn;

위치 49의 Xaa는 Met, Arg, Ala, Gly, Pro, Asn, His 또는 Asp;

위치 50의 Xaa는 Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met 또는 Gln;

위치 51의 Xaa는 Asn, Arg, Met, Pro, Ser, Thr 또는 His;

위치 52의 Xaa는 Asn, His, Arg, Leu, Gly, Ser 또는 Thr;

위치 53의 Xaa는 Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser 또는 Met;

위치 54의 Xaa는 Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala 또는 Leu;

위치 55의 Xaa는 Arg, Thr, Val, Ser, Leu 또는 Gly;

위치 56의 Xaa는 Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val 또는 Lys;

위치 57의 Xaa는 Asn 또는 Gly;

위치 58의 Xaa는 Leu, Ser, Asp, Arg, Gln, Val 또는 Cys;

위치 59의 Xaa는 Glu Tyr, His, Leu, Pro 또는 Arg;

위치 60의 Xaa는 Ala, Ser, Pro, Tyr, Asn 또는 Thr;

위치 61의 Xaa는 Phe, Asn, Glu, Pro, Lys, Arg 또는 Ser;

위치 62의 Xaa는 Asn, His, Val, Arg, Pro, Thr, Asp 또는 Ile;

위치 63의 Xaa는 Arg, Tyr, Trp, Lys, Ser, His, Pro 또는 Val;

위치 64의 Xaa는 Ala, Asn, Pro, Ser 또는 Lys;

위치 65의 Xaa는 Val, Thr, Pro, His, Leu, Phe 또는 Ser;

위치 66의 Xaa는 Lys, Ile, Arg, Val, Asn, Glu 또는 Ser;

위치 67의 Xaa는 Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro 또는 His;

위치 68의 Xaa는 Leu, Val, Trp, Ser, Ile, Phe, Thr 또는 His;

위치 69의 Xaa는 Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly 또는 Leu;

위치 70의 Xaa는 Asn, Leu, Val, Trp, Pro 또는 Ala;

위치 71의 Xaa는 Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp 또는 Asn;

위치 72의 Xaa는 Ser, Glu, Met, Ala, His, Asn, Arg 또는 Asp;

위치 73의 Xaa는 Ala, Glu, Asp, Leu, Ser, Gly, Thr 또는 Arg;

위치 74의 Xaa는 Ile, Met, Thr, Pro, Arg, Gly 또는 Ala;

위치 75의 Xaa는 Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln 또는 Leu;

위치 76의 Xaa는 Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly 또는 Asp;

위치 77의 Xaa는 Ile, Ser, Arg, Thr 또는 Leu;

위치 78의 Xaa는 Leu, Ala, Ser, Glu, Phe, Gly 또는 Arg;

위치 79의 Xaa는 Lys, Thr, Asn, Met, Arg, Ile, Gly 또는 Asp;

위치 80의 Xaa는 Asn, Trp, Val, Gly, Thr, Leu, Glu 또는 Arg;

위치 81의 Xaa는 Leu, Gln, Gly, Ala, Trp, Arg, Val 또는 Lys;

위치 82의 Xaa는 Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met 또는 Val;

위치 83의 Xaa는 Pro, Ala, Thr, Trp, Arg 또는 Met;

위치 84의 Xaa는 Cys, Glu, Gly, Arg, Met 또는 Val;

위치 85의 Xaa는 Leu, Asn, Val 또는 Gln;

위치 86의 Xaa는 Pro, Cys, Arg, Ala 또는 Lys;

위치 87의 Xaa는 Leu, Ser, Trp 또는 Gly;

위치 88의 Xaa는 Ala, Lys, Arg, Val 또는 Trp;

위치 89의 Xaa는 Thr, Asp, Cys, Leu, Val, Glu, His, Asn 또는 Ser;

위치 90의 Xaa는 Ala, Pro, Ser, Thr, Gly, Asp, Ile 또는 Met;

위치 91의 Xaa는 Ala, Pro, Ser, Thr, Phe, Leu, Asp 또는 His;

위치 92의 Xaa는 Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile 또는 Leu;

위치 93의 Xaa는 Thr, Asp, Ser, Asn, Pro, Ala, Leu 또는 Arg;

위치 94의 Xaa는 Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala 또는 Pro;

위치 95의 Xaa는 His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile 또는 Tyr;

위치 96의 Xaa는 Pro, Lys, Tyr, Gly, Ile 또는 Thr;

위치 97의 Xaa는 Ile, Val, Lys, Ala 또는 Asn;

위치 98의 Xaa는 His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr 또는 Pro;

위치 99의 Xaa는 le, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe 또는 His;

위치 100의 Xaa는 Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln 또는 Pro;

위치 101의 Xaa는 Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu 또는 Gln;

위치 102의 Xaa는 Gly, Leu, Glu, Lys, Ser, Tyr 또는 Pro;

위치 103의 Xaa는 Asp 또는 Ser;

위치 104의 Xaa는 Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe 또는 Gly;

위치 105의 Xaa는 Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp 또는 His;

위치 106의 Xaa는 Glu, Ser, Ala, Lys, Thr, Ile, Gly 또는 Pro;

위치 108의 Xaa는 Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala 또는 Pro;

위치 109의 Xaa는 Arg, Thr, Pro, Glu, Tyr, Leu, Ser 또는 Gly;

위치 110의 Xaa는 Lys, Ala, Asn, Thr, Leu, Arg, Gln, His, Glu, Ser 또는 Trp;

위치 111의 Xaa는 Leu, Ile, Arg, Asp 또는 Met;

위치 112의 Xaa는 Thr, Val, Gln, Tyr, Glu, His, Ser 또는 Phe;

위치 113의 Xaa는 Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val 또는 Asn;

위치 114의 Xaa는 Tyr, Cys, His, Ser, Trp, Arg 또는 Leu;

위치 115의 Xaa는 Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp 또는 Met;

위치 116의 Xaa는 Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln 또는 Ile;

위치 117의 Xaa는 Thr, Ser, Asn, Ile, Trp, Lys 또는 Pro;

위치 118의 Xaa는 Leu, Ser, Pro, Ala, Glu, Cys, Asp 또는 Tyr;

위치 119의 Xaa는 Glu, Ser, Lys, Pro, Leu, Thr, Tyr 또는 Arg;

위치 120의 Xaa는 Asn, Ala, Pro, Leu, His, Val 또는 Gln;

위치 121의 Xaa는 Ala, Ser, Ile, Asn, Pro, Lys, Asp 또는 Gly;

위치 122의 Xaa는 Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr 또는 Cys;

위치 123의 Xaa는 Ala, Met, Glu, His, Ser, Pro, Tyr 또는 Leu이고;

N-말단으로부터의 1-14 아미노산, 또는 C-말단으로부터의 1-15 아미노산, 또는 N-말단으로부터의 1-14 아미노산 및 C-말단으로부터의 1-15 아미노산 모두는 상기 변형된 사람 IL-3 아미노산 서열의 C-말단으로부터 선택적으로 결실되고; Xaa로 나타낸 아미노산 중 1 내지 44개는 천연 (1-133) 사람 인터루킨-3의 대응 아미노산과 상이하다.

(V) 콜로니자극인자, 시토카인, 림포카인, 인터루킨 및 조혈성장인자로 구성되는 군으로부터 선택된 인자.

또한 상기 식에서 L₁은 R₁을 R₂에 연결할 수 있는 링커이고;

상기 조혈 단백질은 바로 앞에 선택적으로 (-1 위치의 메티오닌), (-1 위치의 알라닌) 또는 (-2 위치의 메티오닌, -1 위치의 알라닌)이 올 수 있다.
제 2 항에 있어서, (IV)의 폴리펩티드가 다음으로 구성되는 군으로부터 선택되는 것을 특징으로 하는 조혈 단백질.

Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys

Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu

Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu

Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly

Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala

Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp

Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu

Glu Gln Ala Gln Glu Gln Gln SEQ ID NO:803;

Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys

Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu

Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly

Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala

Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp

Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu

Glu Gln Ala Gln Glu Gln Gln SEQ ID NO:804;

Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys

Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu

Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu

Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly

Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala

Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp

Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu

Glu Gln Ala Gln Glu Gln Gln SEQ ID NO:805; 및

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln SEQ ID NO:806.
다음 식의 아미노산 서열로 구성되는 것을 특징으로 하는 조혈 단백질:

R₁-L₁-R₂, R₂-L₁-R₁, R₁-R₂, 또는 R₂-R₁

상기 식에서 R₁은 다음 식의 변형된 flt-3 리간드 아미노산 서열로 구성되는 폴리펩티드이다.

여기서 N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

28-29 42-43 93-94

29-30 64-65 94-95

30-31 65-66 95-96

31-32 66-67 96-97

32-33 86-87 97-98

34-35 87-88 98-99

36-37 88-89 9 9-100

37-38 89-90 100-101

38-39 90-91 101-102

39-40 91-92 102-103

40-41 92-93

41-42

또한, 상기 식에서 R₂는 다음 식의 변형된 사람 IL-3 아미노산 서열로 구성되는 폴리펩티드이다.

여기서 위치 17의 Xaa는 Ser, Lys, Gly, Asp, Met, Gln 또는 Arg;

위치 18의 Xaa는 Asn, His, Leu, Ile, Phe, Arg 또는 Gln;

위치 19의 Xaa는 Met, Phe, Ile, Arg, Gly, Ala 또는 Cys;

위치 20의 Xaa는 Ile, Cys, Gln, Glu, Arg, Pro 또는 Ala;

위치 21의 Xaa는 Asp, Phe, Lys, Arg, Ala, Gly, Glu, Gln, Asn, Thr, Ser 또는 Val;

위치 22의 Xaa는 Glu, Trp, Pro, Ser, Ala, His, Asp, Asn, Gln, Leu, Val 또는 Gly;

위치 23의 Xaa는 Ile, Val, Ala, Gly, Trp, Lys, Phe, Leu, Ser 또는 Arg;

위치 24의 Xaa는 Ile, Gly, Val, Arg, Ser, Phe 또는 Leu;

위치 25의 Xaa는 Thr, His, Gly, Gln, Arg, Pro 또는 Ala;

위치 26의 Xaa는 His, Thr, Phe, Gly, Arg, Ala 또는 Trp;

위치 27의 Xaa는 Leu, Gly, Arg, Thr, Ser 또는 Ala;

위치 28의 Xaa는 Lys, Arg, Leu, Gln, Gly, Pro, Val 또는 Trp;

위치 29의 Xaa는 Gln, Asn, Leu, Pro, Arg 또는 Val;

위치 30의 Xaa는 Pro, His, Thr, Gly, Asp, Gln, Ser, Leu 또는 Lys;

위치 31의 Xaa는 Pro, Asp, Gly, Ala, Arg, Leu 또는 Gln;

위치 32의 Xaa는 Leu, Val, Arg, Gln, Asn, Gly, Ala 또는 Glu;

위치 33의 Xaa는 Pro, Leu, Gln, Ala, Thr 또는 Glu;

위치 34의 Xaa는 Leu, Val, Gly, Ser, Lys, Glu, Gln, Thr, Arg, Ala, Phe, Ile 또는 Met;

위치 35의 Xaa는 Leu, Ala, Gly, Asn, Pro, Gln 또는 Val;

위치 36의 Xaa는 Asp, Leu 또는 Val;

위치 37의 Xaa는 Phe, Ser, Pro, Trp 또는 Ile;

위치 38의 Xaa는 Asn 또는 Ala;

위치 40의 Xaa는 Leu, Trp 또는 Arg;

위치 41의 Xaa는 Asn, Cys, Arg, Leu, His, Met 또는 Pro;

위치 42의 Xaa는 Gly, Asp, Ser, Cys, Asn, Lys, Thr, Leu, Val, Glu, Phe, Tyr, Ile, Met 또는 Ala;

위치 43의 Xaa는 Glu, Asn, Tyr, Leu, Phe, Asp, Ala, Cys, Gln, Arg, Thr, Gly 또는 Ser;

위치 44의 Xaa는 Asp, Ser, Leu, Arg, Lys, Thr, Met, Trp, Glu, Asn, Gln, Ala 또는 Pro;

위치 45의 Xaa는 Gln, Pro, Phe, Val, Met, Leu, Thr, Lys, Trp, Asp, Asn, Arg, Ser, Ala, Ile, Glu 또는 His;

위치 46의 Xaa는 Asp, Phe, Ser, Thr, Cys, Glu, Asn, Gln, Lys, His, Ala, Tyr, Ile, Val 또는 Gly;

위치 47의 Xaa는 Ile, Gly, Val, Ser, Arg, Pro 또는 His;

위치 48의 Xaa는 Leu, Ser, Cys, Arg, Ile, His, Phe, Glu, Lys, Thr, Ala, Met, Val 또는 Asn;

위치 49의 Xaa는 Met, Arg, Ala, Gly, Pro, Asn, His 또는 Asp;

위치 50의 Xaa는 Glu, Leu, Thr, Asp, Tyr, Lys, Asn, Ser, Ala, Ile, Val, His, Phe, Met 또는 Gln;

위치 51의 Xaa는 Asn, Arg, Met, Pro, Ser, Thr 또는 His;

위치 52의 Xaa는 Asn, His, Arg, Leu, Gly, Ser 또는 Thr;

위치 53의 Xaa는 Leu, Thr, Ala, Gly, Glu, Pro, Lys, Ser 또는 Met;

위치 54의 Xaa는 Arg, Asp, Ile, Ser, Val, Thr, Gln, Asn, Lys, His, Ala 또는 Leu;

위치 55의 Xaa는 Arg, Thr, Val, Ser, Leu 또는 Gly;

위치 56의 Xaa는 Pro, Gly, Cys, Ser, Gln, Glu, Arg, His, Thr, Ala, Tyr, Phe, Leu, Val 또는 Lys;

위치 57의 Xaa는 Asn 또는 Gly;

위치 58의 Xaa는 Leu, Ser, Asp, Arg, Gln, Val 또는 Cys;

위치 59의 Xaa는 Glu Tyr, His, Leu, Pro 또는 Arg;

위치 60의 Xaa는 Ala, Ser, Pro, Tyr, Asn 또는 Thr;

위치 61의 Xaa는 Phe, Asn, Glu, Pro, Lys, Arg 또는 Ser;

위치 62의 Xaa는 Asn, His, Val, Arg, Pro, Thr, Asp 또는 Ile;

위치 63의 Xaa는 Arg, Tyr, Trp, Lys, Ser, His, Pro 또는 Val;

위치 64의 Xaa는 Ala, Asn, Pro, Ser 또는 Lys;

위치 65의 Xaa는 Val, Thr, Pro, His, Leu, Phe 또는 Ser;

위치 66의 Xaa는 Lys, Ile, Arg, Val, Asn, Glu 또는 Ser;

위치 67의 Xaa는 Ser, Ala, Phe, Val, Gly, Asn, Ile, Pro 또는 His;

위치 68의 Xaa는 Leu, Val, Trp, Ser, Ile, Phe, Thr 또는 His;

위치 69의 Xaa는 Gln, Ala, Pro, Thr, Glu, Arg, Trp, Gly 또는 Leu;

위치 70의 Xaa는 Asn, Leu, Val, Trp, Pro 또는 Ala;

위치 71의 Xaa는 Ala, Met, Leu, Pro, Arg, Glu, Thr, Gln, Trp 또는 Asn;

위치 72의 Xaa는 Ser, Glu, Met, Ala, His, Asn, Arg 또는 Asp;

위치 73의 Xaa는 Ala, Glu, Asp, Leu, Ser, Gly, Thr 또는 Arg;

위치 74의 Xaa는 Ile, Met, Thr, Pro, Arg, Gly 또는 Ala;

위치 75의 Xaa는 Glu, Lys, Gly, Asp, Pro, Trp, Arg, Ser, Gln 또는 Leu;

위치 76의 Xaa는 Ser, Val, Ala, Asn, Trp, Glu, Pro, Gly 또는 Asp;

위치 77의 Xaa는 Ile, Ser, Arg, Thr 또는 Leu;

위치 78의 Xaa는 Leu, Ala, Ser, Glu, Phe, Gly 또는 Arg;

위치 79의 Xaa는 Lys, Thr, Asn, Met, Arg, Ile, Gly 또는 Asp;

위치 80의 Xaa는 Asn, Trp, Val, Gly, Thr, Leu, Glu 또는 Arg;

위치 81의 Xaa는 Leu, Gln, Gly, Ala, Trp, Arg, Val 또는 Lys;

위치 82의 Xaa는 Leu, Gln, Lys, Trp, Arg, Asp, Glu, Asn, His, Thr, Ser, Ala, Tyr, Phe, Ile, Met 또는 Val;

위치 83의 Xaa는 Pro, Ala, Thr, Trp, Arg 또는 Met;

위치 84의 Xaa는 Cys, Glu, Gly, Arg, Met 또는 Val;

위치 85의 Xaa는 Leu, Asn, Val 또는 Gln;

위치 86의 Xaa는 Pro, Cys, Arg, Ala 또는 Lys;

위치 87의 Xaa는 Leu, Ser, Trp 또는 Gly;

위치 88의 Xaa는 Ala, Lys, Arg, Val 또는 Trp;

위치 89의 Xaa는 Thr, Asp, Cys, Leu, Val, Glu, His, Asn 또는 Ser;

위치 90의 Xaa는 Ala, Pro, Ser, Thr, Gly, Asp, Ile 또는 Met;

위치 91의 Xaa는 Ala, Pro, Ser, Thr, Phe, Leu, Asp 또는 His;

위치 92의 Xaa는 Pro, Phe, Arg, Ser, Lys, His, Ala, Gly, Ile 또는 Leu;

위치 93의 Xaa는 Thr, Asp, Ser, Asn, Pro, Ala, Leu 또는 Arg;

위치 94의 Xaa는 Arg, Ile, Ser, Glu, Leu, Val, Gln, Lys, His, Ala 또는 Pro;

위치 95의 Xaa는 His, Gln, Pro, Arg, Val, Leu, Gly, Thr, Asn, Lys, Ser, Ala, Trp, Phe, Ile 또는 Tyr;

위치 96의 Xaa는 Pro, Lys, Tyr, Gly, Ile 또는 Thr;

위치 97의 Xaa는 Ile, Val, Lys, Ala 또는 Asn;

위치 98의 Xaa는 His, Ile, Asn, Leu, Asp, Ala, Thr, Glu, Gln, Ser, Phe, Met, Val, Lys, Arg, Tyr 또는 Pro;

위치 99의 Xaa는 le, Leu, Arg, Asp, Val, Pro, Gln, Gly, Ser, Phe 또는 His;

위치 100의 Xaa는 Lys, Tyr, Leu, His, Arg, Ile, Ser, Gln 또는 Pro;

위치 101의 Xaa는 Asp, Pro, Met, Lys, His, Thr, Val, Tyr, Glu, Asn, Ser, Ala, Gly, Ile, Leu 또는 Gln;

위치 102의 Xaa는 Gly, Leu, Glu, Lys, Ser, Tyr 또는 Pro;

위치 103의 Xaa는 Asp 또는 Ser;

위치 104의 Xaa는 Trp, Val, Cys, Tyr, Thr, Met, Pro, Leu, Gln, Lys, Ala, Phe 또는 Gly;

위치 105의 Xaa는 Asn, Pro, Ala, Phe, Ser, Trp, Gln, Tyr, Leu, Lys, Ile, Asp 또는 His;

위치 106의 Xaa는 Glu, Ser, Ala, Lys, Thr, Ile, Gly 또는 Pro;

위치 108의 Xaa는 Arg, Lys, Asp, Leu, Thr, Ile, Gln, His, Ser, Ala 또는 Pro;

위치 109의 Xaa는 Arg, Thr, Pro, Glu, Tyr, Leu, Ser 또는 Gly;

위치 110의 Xaa는 Lys, Ala, Asn, Thr, Leu, Arg, Gln, His, Glu, Ser 또는 Trp;

위치 111의 Xaa는 Leu, Ile, Arg, Asp 또는 Met;

위치 112의 Xaa는 Thr, Val, Gln, Tyr, Glu, His, Ser 또는 Phe;

위치 113의 Xaa는 Phe, Ser, Cys, His, Gly, Trp, Tyr, Asp, Lys, Leu, Ile, Val 또는 Asn;

위치 114의 Xaa는 Tyr, Cys, His, Ser, Trp, Arg 또는 Leu;

위치 115의 Xaa는 Leu, Asn, Val, Pro, Arg, Ala, His, Thr, Trp 또는 Met;

위치 116의 Xaa는 Lys, Leu, Pro, Thr, Met, Asp, Val, Glu, Arg, Trp, Ser, Asn, His, Ala, Tyr, Phe, Gln 또는 Ile;

위치 117의 Xaa는 Thr, Ser, Asn, Ile, Trp, Lys 또는 Pro;

위치 118의 Xaa는 Leu, Ser, Pro, Ala, Glu, Cys, Asp 또는 Tyr;

위치 119의 Xaa는 Glu, Ser, Lys, Pro, Leu, Thr, Tyr 또는 Arg;

위치 120의 Xaa는 Asn, Ala, Pro, Leu, His, Val 또는 Gln;

위치 121의 Xaa는 Ala, Ser, Ile, Asn, Pro, Lys, Asp 또는 Gly;

위치 122의 Xaa는 Gln, Ser, Met, Trp, Arg, Phe, Pro, His, Ile, Tyr 또는 Cys;

위치 123의 Xaa는 Ala, Met, Glu, His, Ser, Pro, Tyr 또는 Leu이고;

N-말단으로부터 1-14 아미노산, 또는 C-말단으로부터 1-15 아미노산, 또는 N-말단으로부터 1-14 아미노산 및 C-말단으로부터 1-15 아미노산이 상기 변형된 사람 인터루킨-3 아미노산 서열의 C-말단으로부터 선택적으로 결실되고; Xaa로 나타낸 아미노산 중 1 내지 44개는 천연 (1-133) 사람 인터루킨-3의 대응 아미노산과 상이하다.

또한 상기 식에서 L₁은 R₁을 R₂에 연결할 수 있는 링커이고;

상기 조혈 단백질 바로 앞에 선택적으로 (-1 위치의 메티오닌), (-1 위치의 알라닌) 또는 (-2 위치의 메티오닌, -1 위치의 알라닌)이 올 수 있다.
제 4 항에 있어서, R₂가 다음으로 구성되는 군으로부터 선택되는 것을 특징으로 하는 조혈 단백질.

Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys

Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu

Asp Val Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu

Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly

Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala

Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp

Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu

Glu Gln Ala Gln Glu Gln Gln SEQ ID NO:803;

Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys

Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu

Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly

Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala

Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp

Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu

Glu Gln Ala Gln Glu Gln Gln SEQ ID NO:804;

Ala Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys

Val Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu

Asp Met Asp Ile Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu

Leu Ala Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly

Ile Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala

Thr Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp

Trp Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu

Glu Gln Ala Gln Glu Gln Gln SEQ ID NO:805; 및

Asn Cys Ser Ile Met Ile Asp Glu Ile Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Ile Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Ile

Glu Ala Ile Leu Arg Asn Leu Gln Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Ile Ile Ile Lys Ala Gly Asp Trp

Gln Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gln Ala Gln Glu Gln Gln SEQ ID NO:806.
다음 식의 아미노산 서열로 구성되는 것을 특징으로 하는 조혈 단백질:

R₁-L₁-R₂, R₂-L₁-R₁, R₁-R₂, 또는 R₂-R₁

상기 식에서 R₁은 다음 식의 변형된 flt-3 리간드 아미노산 서열로 구성되는폴리펩티드이다.

여기서 N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

28-29 42-43 93-94

29-30 64-65 94-95

30-31 65-66 95-96

31-32 66-67 96-97

32-33 86-87 97-98

34-35 87-88 98-99

36-37 88-89 9 9-100

37-38 89-90 100-101

38-39 90-91 101-102

39-40 91-92 102-103

40-41 92-93

41-42

또한 상기 식에서 R₂는 콜로니자극인자, 시토카인, 림포카인, 인터루킨 및 조혈성장인자로 구성되는 군으로부터 선택된 인자이고;

L₁은 R₁을 R₂에 연결할 수 있는 링커이고;

상기 조혈 단백질 바로 앞에 선택적으로 (-1 위치의 메티오닌), (-1 위치의 알라닌) 또는 (-2 위치의 메티오닌, -1 위치의 알라닌)이 올 수 있다.
다음 식의 아미노산 서열로 구성되는 것을 특징으로 하는 조혈 단백질:

R₁-L₁-R₂, R₂-L₁-R₁, R₁-R₂, 또는 R₂-R₁

상기 식에서 R₁은 다음 식의 변형된 flt-3 리간드 아미노산 서열로 구성되는 폴리펩티드이다.

여기서 N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

28-29 42-43 93-94

29-30 64-65 94-95

30-31 65-66 95-96

31-32 66-67 96-97

32-33 86-87 97-98

34-35 87-88 98-99

36-37 88-89 9 9-100

37-38 89-90 100-101

38-39 90-91 101-102

39-40 91-92 102-103

40-41 92-93

41-42

또한 상기 식에서 R₂는 다음 식의 변형된 사람 G-CSF 아미노산 서열로 구성되는 폴리펩티드이다.

여기서 위치 1의 Xaa는 Thr, Ser, Arg, Tyr 또는 Gly;

위치 2의 Xaa는 Pro 또는 Leu;

위치 3의 Xaa는 Leu, Arg, Tyr 또는 Ser;

위치 13의 Xaa는 Phe, Ser, His, Thr 또는 Pro;

위치 16의 Xaa는 Lys, Pro, Ser, Thr 또는 His;

위치 17의 Xaa는 Cys, Ser, Gly, Ala, Ile, Tyr 또는 Arg;

위치 18의 Xaa는 Leu, Thr, Pro, His, Ile 또는 Cys;

위치 22의 Xaa는 Arg, Tyr, Ser, Thr 또는 Ala;

위치 24의 Xaa는 Ile, Pro, Tyr 또는 Leu;

위치 27의 Xaa는 Asp 또는 Gly;

위치 30의 Xaa는 Ala, Ile, Leu 또는 Gly;

위치 34의 Xaa는 Lys 또는 Ser;

위치 36의 Xaa는 Cys 또는 Ser;

위치 42의 Xaa는 Cys 또는 Ser;

위치 43의 Xaa는 His, Thr, Gly, Val, Lys, Trp, Ala, Arg, Cys 또는 Leu;

위치 44의 Xaa는 Pro, Gly, Arg, Asp, Val, Ala, His, Trp, Gln 또는 Thr;

위치 46의 Xaa는 Glu, Arg, Phe, Arg, Ile 또는 Ala;

위치 47의 Xaa는 Leu 또는 Thr;

위치 49의 Xaa는 Leu, Phe, Arg 또는 Ser;

위치 50의 Xaa는 Leu, Ile, His, Pro 또는 Tyr;

위치 54의 Xaa는 Leu 또는 His;

위치 64의 Xaa는 Cys 또는 Ser;

위치 67의 Xaa는 Gln, Lys, Leu 또는 Cys;

위치 70의 Xaa는 Gln, Pro, Leu, Arg 또는 Ser;

위치 74의 Xaa는 Cys 또는 Ser;

위치 104의 Xaa는 Asp, Gly 또는 Val;

위치 108의 Xaa는 Leu, Ala, Val, Arg, Trp, Gln 또는 Gly;

위치 115의 Xaa는 Thr, His, Leu 또는 Ala;

위치 120의 Xaa는 Gln, Gly, Arg, Lys 또는 His;

위치 123의 Xaa는 Glu, Arg, Phe 또는 Thr;

위치 144의 Xaa는 Phe, His, Arg, Pro, Leu, Gln 또는 Glu;

위치 146의 Xaa는 Arg 또는 Gln;

위치 147의 Xaa는 Arg 또는 Gln;

위치 156의 Xaa는 His, Gly 또는 Ser;

위치 159의 Xaa는 Ser, Arg, Thr, Tyr, Val 또는 Gly;

위치 162의 Xaa는 Glu, Leu, Gly 또는 Trp;

위치 163의 Xaa는 Val, Gly, Arg 또는 Ala;

위치 169의 Xaa는 Arg, Ser, Leu, Arg 또는 Cys;

위치 170의 Xaa는 His, Arg 또는 Ser이고;

여기서 N-말단으로부터의 1-11 아미노산, 또는 C-말단으로부터의 1-5 아미노산, 또는 N-말단으로부터의 1-11 아미노산 및 C-말단으로부터의 1-5 아미노산 모두는 상기 변형된 사람 G-CSF 아미노산 서열로부터 선택적으로 결실되고;

N-말단은 C-말단에 직접 연결되거나, 또는 N-말단을 C-말단에 연결할 수 있고 다음 아미노산들에서 새로운 C- 및 N-말단을 갖는 링커(L₂)를 통해 연결된다.

38-39 62-63 123-124

39-40 63-64 124-125

40-41 64-65 125-126

41-42 65-66 126-127

42-43 66-67 128-129

43-44 67-68 128-129

45-46 68-69 129-130

48-49 69-70 130-131

49-50 70-71 131-132

52-53 71-72 132-133

53-54 91-92 133-134

54-55 92-93 134-135

55-56 93-94 135-136

56-57 94-95 136-137

57-58 95-96 137-138

58-59 96-97 138-139

59-60 97-98 139-140

60-61 98-99 140-141

61-62 99-100 141-142

또는 142-143

또한 상기 식에서 L₁은 R₁을 R₂에 연결할 수 있는 링커이고;

상기 조혈 단백질 바로 앞에 선택적으로 (-1 위치의 메티오닌), (-1 위치의 알라닌) 또는 (-2 위치의 메티오닌, -1 위치의 알라닌)이 올 수 있다.
제 1 항, 제 2 항, 제 3 항, 제 4 항, 제 5 항, 제 6 항 또는 제 7 항에 있어서, 상기 링커(L₂)가 다음으로 구성되는 군으로부터 선택되는 것을 특징으로 하는 조혈 단백질.

Ser;

Asn;

Gly;

Thr;

GlySer;

AlaAla;

GlySerGly;

GlyGlyGly;

GlyAsnGly;

GlyAlaGly;

GlyThrGly;

AlaSerAla;

AlaAlaAla;

GlyGlyGlySer SEQ ID NO:778;

GlyGlyGlySerGlyGlyGlySer SEQ ID NO:779;

GlyGlyGlySerGlyGlyGlySerGlyGlyGlySer SEQ ID NO:780;

SerGlyGlySerGlyGlySer SEQ ID NO:781;

GluPheGlyAsnMet SEQ ID NO:782;

GluPheGlyGlyAsnMet SEQ ID NO:783;

GluPheGlyGlyAsnGlyGlyAsnMet SEQ ID NO:784;

GlyGlySerAspMetAlaGly SEQ ID NO:785;

SerGlyGlyAsnGly SEQ ID NO:786;

SerGlyGlyAsnGlySerGlyGlyAsnGly SEQ ID NO:787;

SerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGly SEQ ID NO:788;

SerGlyGlySerGlySerGlyGlySerGly SEQ ID NO:789;

SerGlyGlySerGlySerGlyGlySerGlySerGlyGlySerGly SEQ ID NO:790;

GlyGlyGlySerGlyGly SEQ ID NO:791;

GlyGlyGlySerGlyGlyGly SEQ ID NO:792;

GlyGlyGlySerGlyGlyGlySerGlyGly SEQ ID NO:793;

GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly SEQ ID NO:794;

GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGly SEQ ID NO:795;

GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly SEQ ID NO:796;

ProProProTrpSerProArgProLeuGlyAlaThrAlaProThrAlaGly GlnProProLeu SEQ ID NO:797;

ProProProTrpSerProArgProLeuGlyAlaThrAlaProThr SEQ ID NO:798; 및

ValGluThrValPheHisArgValSerGlnAspGlyLeuLeuThrSer SEQ ID NO:799.
제 1 항에 있어서, 다음으로 구성되는 군으로부터 선택되는 것을 특징으로 하는 조혈 단백질.

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeu

AlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu

GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSer

CysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu

ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCys

GlnProAspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsnGlyThrGlnAsp

CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSer

AspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID

NO:581;

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeu

AlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu

GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSer

CysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu

ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCys

GlnProAspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsnGlyThrGlnAsp

CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSer

AspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID

NO:582;

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGlu

IleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln

ThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrp

IleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr

LeuSerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp

PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal

AlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGln

ArgTrpMetGluArgLeuLysThrValAlaGly SEQ ID NO:583;

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaSerLysMetGlnGlyLeuLeuGluArgValAsnThrGlu

IleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln

ThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrp

IleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr

LeuSerGlyGlyAsnGlySerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSer

ProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAsp

TyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg

LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SEQ ID

NO:584;

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeu

AlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu

GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSer

CysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeu

ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCys

GlnProAspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGly

AsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLys

IleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeu

Gln SEQ ID NO:585;

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSer

ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln

AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGly

AsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLys

IleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeu

GlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu

ArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGlu

IleHisPheValThrLysCysAlaPheGlnPro SEQ ID NO:586;

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSer

ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln

AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGly

AsnGlySerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSer

AspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThr

ValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAla

GlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGlu

ArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnPro SEQ ID

NO:587;

AlaAsnCysSerIleMetIleAspGluIleIleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly

IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer

ArgHisProIleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer

ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnIleSer

ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln

AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGly

AsnGlySerGlyGlyAsnGlySerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHis

SerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln

AspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrp

ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet

GlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln

Pro SEQ ID NO:588;

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu

LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal

ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeu

LeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg

CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGly

GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerPro

IleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal

ThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGly

GlySerAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSer

LeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyr

LysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeu

SerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPhe

LeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThr

LeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAla

ProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGly

GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeu

AlaGlnPro SEQ ID NO:743;

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGlu

LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeu

CysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly

SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe

GlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSer

GluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGln

CysGlnProAspSerSerThrLeuTyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGly

GlyGlySerAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLys

SerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThr

TyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaPro

LeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeu

PheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAsp

ThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMet

AlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAla

GlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHis

LeuAlaGlnPro SEQ ID NO:659;

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnVal

ArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHis

ProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysPro

SerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGly

LeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAsp

ValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGln

ProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuVal

AlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyr

ValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrIleAsnProSerPro

ProSerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArg

LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeu

LeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCys

LeuArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeu

LysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer

ThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer

GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGlu

LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID

NO:705;

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu

LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal

ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnIleSerArgLeu

LeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArg

CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGly

GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerPro

IleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal

ThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGlyGly

GlySerAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSer

LeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyr

LysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIleProTrpAlaProLeu

SerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPhe

LeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThr

LeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGluLeuGlyMetAla

ProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGly

GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeu

AlaGlnPro SEQ ID NO:743.
제 1 항, 제 2 항 또는 제 6 항에 있어서, 상기 콜로니자극인자가 GM-CSF, G-CSF, G-CSF Ser¹⁷, c-mpl 리간드(TPO), M-CSF, 에리트로포이에틴(EPO), IL-1, IL-4, IL-2, IL-3, IL-5, IL 6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-15, LIF, flt3/flk2 리간드, 사람성장호르몬, B-세포성장인자, B-세포분화인자, 호산구분화인자 및 간세포인자(SCF)로 구성되는 군으로부터 선택되는 것을 특징으로 하는 조혈 단백질.
제 10 항에 있어서, 상기 콜로니자극인자가 G-CSF, G-CSF Ser¹⁷, G-CSF Ala¹⁷ 및 c-mpl 리간드(TPO)로 구성되는 군으로부터 선택되는 것을 특징으로 하는 조혈 단백질.
제 1 항의 조혈 단백질을 암호화하는 것을 특징으로 하는 핵산 분자.
제 2 항의 조혈 단백질을 암호화하는 것을 특징으로 하는 핵산 분자.
제 3 항의 조혈 단백질을 암호화하는 것을 특징으로 하는 핵산 분자.
제 4 항의 조혈 단백질을 암호화하는 것을 특징으로 하는 핵산 분자.
제 5 항의 조혈 단백질을 암호화하는 것을 특징으로 하는 핵산 분자.
제 6 항의 조혈 단백질을 암호화하는 것을 특징으로 하는 핵산 분자.
제 7 항의 조혈 단백질을 암호화하는 것을 특징으로 하는 핵산 분자.
제 8 항의 조혈 단백질을 암호화하는 것을 특징으로 하는 핵산 분자.
제 9 항의 조혈 단백질을 암호화하는 것을 특징으로 하는 핵산 분자.
제 10 항의 조혈 단백질을 암호화하는 것을 특징으로 하는 핵산 분자.
제 11 항의 조혈 단백질을 암호화하는 것을 특징으로 하는 핵산 분자.
제 12 항에 있어서, 다음으로 구성되는 군으로부터 선택되는 것을 특징으로 하는 핵산 분자.

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCAGGCGGT

AACGGCAGTGGAGGTAATGGCACCCAGGACTGCTCCTTCCAACACAGCCC

CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC

TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO:121;

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG

CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG

GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA

ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCTGGAGGT

AACGGATCCGGTGGCAATGGGAGCGGCGGAAATGGAACCCAGGACTGCTC

CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC

TGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG

CAG SEQ ID NO:122;

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGTCTGGCGGCAACGGCACGCAGGACTGCTCCTTCCAAC

ACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGAC

TACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGA

GGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGG

AGCGGCTCAAGACTGTCGCTGGG SEQ ID NO:123;

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGTCTGGAGGTAACGGATCCGGAGGTAATGGCACCCAGG

ACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC

CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTC

CAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGG

CACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGG SEQ ID NO:124;

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG

CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG

TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT

CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG

ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA

CTCCTCAACCCTGTCTGGAGGTAACGGATCCGGTGGCAATGGGAGCGGCG

GAAATGGAACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC

TTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCC

AGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCT

GGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCT

GGG SEQ ID NO:125;

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCTGGCGGC

AACGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTT

CGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAG

TCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGG

CGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGG

GTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTG

TCACCAAATGTGCCTTTCAGCCC SEQ ID NO:126;

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCAGGCGGT

AACGGCAGTGGAGGTAATGGCACCCAGGACTGCTCCTTCCAACACAGCCC

CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC

TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTC

TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCT

CAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACA

CGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC SEQ ID NO:127;

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC

ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA

TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG

GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA

TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC

TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG

TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC

TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTCTGGAGGT

AACGGCAGTGGTGGTAATGGGAGCGGCGGAAATGGAACCCAGGACTGCTC

CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC

TGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG

CAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC

TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG

CCC SEQ ID NO:128;

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC

AAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC

ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC

CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG

TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA

GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCC

ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTC

ACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGC

GGCTCCAACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCT

TTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTAC

AAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTG

AGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTC

CTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACA

CTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCC

CCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGA

GGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTT

GCGCAGCCG SEQ ID NO:282;

GGCCACTCAGGACTGCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGA

GCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCT

CTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGG

GTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTT

TCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC

CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA

GTGTCAGCCCGACTCCTCAACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGG

CGGCGGCTCCAACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAA

GTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCAC

CTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCC

CCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCT

TTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGA

CACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAAT

GGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGC

AGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCA

CCTTGCGCAGCCG SEQ ID NO:198;

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTG

AGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCAC

CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC

AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGG

CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC

GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAG

CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT

GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC

GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCT

CCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTGATGAAGAACTGTGTGGTGGTCTGTGGCGG

CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTG

CTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGT

CTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG

AAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA

ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGT

GGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAG

CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID

NO:244;

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC

AAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC

ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC

CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG

TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA

GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCC

ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTC

ACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGC

GGCTCCAACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCT

TTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTAC

AAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTG

AGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTC

CTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACA

CTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCC

CCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGA

GGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTT

GCGCAGCCG SEQ ID NO:282.
조혈 단백질의 제조방법으로서, 제 12 항, 제 13 항, 제 14 항, 제 15 항, 제 16 항, 제 17 항, 제 18 항, 제 19 항, 제 20 항, 제 21 항, 제 22 항 또는 제 23 항의 핵산 분자를 포함하는 복제가능 벡터로 형질전환되거나 또는 트랜스펙션된 숙주세포를 상기 조혈 단백질을 발현시키는 방식으로 적당한 영양 조건 하에서 성장시키고, 상기 조혈 단백질을 회수하는 것을 포함하는 것을 특징으로 하는 조혈단백질의 제조방법.
제 1 항, 제 2 항, 제 3 항, 제 4 항, 제 5 항, 제 6 항, 제 7 항, 제 9 항 또는 제 10 항에 따른 조혈 단백질 및 약학적으로 허용되는 담체를 포함하는 것을 특징으로 하는 종양, 감염 또는 자가면역병 치료용 약학적 조성물.
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조혈 세포의 선택적 생체외 증량을 위한 방법으로서,

(a) 상기 조혈 세포를 제 1 항의 조혈 단백질을 포함하는 배양배지에서 배양하는 단계; 및

(b) 상기 배양된 세포를 수거하는 단계

를 포함하는 것을 특징으로 하는 방법.
조혈 세포의 선택적 생체외 증량을 위한 방법으로서,

(a) 조혈 세포를 다른 세포로부터 분리하는 단계;

(b) 상기 분리된 조혈 세포를 제 1 항의 조혈 단백질을 포함하는 배양배지에서 배양하는 단계; 및

(c) 상기 배양된 세포를 수거하는 단계

를 포함하는 것을 특징으로 하는 방법.
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수상세포의 제조방법으로서,

(a) 조혈 전구세포 또는 CD34+ 세포를 다른 세포로부터 분리하는 단계; 및

(b) 상기 조혈 전구세포 또는 CD34+ 세포를 제 1 항, 제 2 항, 제 3 항 또는 제 4 항의 조혈 단백질을 포함하는 성장배지에서 배양하는 단계

를 포함하는 것을 특징으로 하는 방법.
제 34 항에 있어서,

c) 상기 배양한 조혈 전구세포 또는 CD34+ 세포를 항원으로 플러싱하는 단계를 더 포함하는 것을 특징으로 하는 방법.
제 34 항에 있어서, 상기 성장배지가 GM-CSF, IL-4, TNF-α, 간세포인자(SCF), flt-3 리간드, IL-3, IL-3 변이체, IL-3 변이체 융합단백질 및 다기능 수용체 아고니스트로 구성되는 군으로부터 선택된 한가지 이상의 인자를 더 포함하는 것을 특징으로 하는 방법.
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