KR0154648B1 - Hair growth and restoration promoter - Google Patents

Abstract

The present invention relates to a hair wool composition useful for preventing hair loss and promoting hair growth. It is a novel wool composition containing certain natural plant components and ethynyl estradiol, which has excellent biosafety and remarkable hair growth promoting effects.

Description

Wool composition

1 is a chart of the results of testing restoration to normal hair in an animal test following application of the wool agent composition of the present invention.

FIG. 2 is a photograph of the results of testing restoration to normal hair in an animal test following application of the wool composition of the present invention. FIG.

The present invention relates to a wool composition useful for preventing hair loss and promoting hair growth with a new wool agent, and more particularly to a new wool composition containing specific natural plant components and ethinyl estradiol. .

Conventionally, many treatments and treatment methods have been implemented to prevent hair loss and hair of the head. For example, this is the application of wool and the growth of hair due to physical irritation to the skin with hair roots and the wearing of decorative wigs. The former is very preferable because natural hair is obtained, and the latter is improper when improvised when natural hair is not obtained, but there is a problem in that it is inconvenient to use and may come off unintentionally.

After all, natural hair is the most desirable, but once it is lost its recovery, ie wool and hair growth, is almost difficult.

The causes of baldness and baldness include: 1) activation of male hormones in organs such as hair roots and sebaceous glands, 2) lowering of blood flow to the follicles, 3) excess sebum secretion, peroxide production, and abnormal growth of the scalp by bacterial growth. , 4) genetic factors, 5) neurosis due to stress, 6) secondary symptoms in the skin, and 7) aging.

Therefore, compounds with the action of eliminating or alleviating the cause of electricity are generally formulated with materials of conventional wool. For example, compounds that inhibit the activation of androgen hormones, such as beta-glychylchin, oxandrone, and cyproteol, and compounds that increase blood flow to the follicles, acetylcholine, menthol, and vitamin E And derivatives thereof.

However, the mechanism of hair loss and hair growth is complex, and simply inhibiting the activation of male hormones or increasing the blood flow of the follicles does not prevent baldness and hair loss sufficiently. Thus, to date, no agent has been substantially effective in alleviating alopecia and promoting hair growth, and in alleviating or treating dandruff production of the head and itching of the scalp.

In view of the above circumstances, the object of the present invention is to search for substances having hair loss prevention and excellent wool action, and as a result, a composition combining a natural plant component and a specific active ingredient exhibits a marked synergistic effect on promoting hair growth. I came to my attention and finished it.

First of all, we tried to find a substance that can promote hair growth in natural plant extraction. As a result of research, the present inventors have already applied for a patent on loganin, which is the main component of cornus extract, which showed excellent hair growth effect. (Publication publication 95-2738). Subsequently, the addition of ethinyl estradiol, a female hormone system commonly used to promote hair growth, has been found in the Cornus extract, which provides an excellent synergistic effect for promoting hair growth, thereby providing a novel wool composition. It is thought that the present invention has been completed.

That is, the present invention is to provide a hair composition that is safe for the living body while preventing the hair loss and promoting the growth of wool and hair by reducing the activation of male hormone which is one of the factors of hair loss.

The natural plant extract used in the present invention is cornus (山水 楡, Cornus fluit or Corni Fructus), which is a pulp from which the seeds of Cornus officinalis S. et Z., Cornaceae (H.) are removed. The shape is spherical, 10 ~ 15mm in diameter, yellowish brown or grayish reddish brown, with fine wrinkles, peculiar smell, and tastes slightly sour and sweet.

The pharmacological action and efficacy of this herbal medicine is good for medicinal diseases of internal medicine, gynecology and pediatrics. It is known to have nourishing effect (强壯, 强 精), and it is known to adjust the height of blood pressure to treat hepatitis and enhance resistance. ). In addition, it is effective as a remedy for the disease, and it is effective for nervous breakdown, neurostable effect, convergence, antibacterial, antifungal, urinary, tinnitus, urine It is a traditional herbal medicine that has been used for the treatment of pain and male genital atrophy, oil well, dysmenorrhea and uterine bleeding.

Meanwhile, four major glycosides (morroniside, loganin, stereoside, and 7-o-methy morroniside) are the main components of cornus oil. )], Along with other compounds related to cornusin B, four anmeric ellagitannin, cornusin A, cornin, gallic acid, It contains tartaric acid, malic acid, vitamin A, large amounts of sugar and fatty oils (palmitic acid, oleic acid, linoleic acid).

Regarding the extraction solvent and the extraction method of the cornus oil, various known ones can be applied. For example, water, methanol, ethanol, or the like may be used as the extraction solvent, and as the extraction method, the plant material may be dried if necessary, followed by mechanical grinding, followed by precipitation in a solvent, followed by heating, stirring, and sonication. .

After extracting the plant component of cornus oil, the extract extract is prepared by concentrating the extract. However, the extracted plant component is a mixture of various components, which has a strong affinity with a solvent (especially water). The operation may not be completely dry solidified, and when dried, it becomes a solid, but when not dried, it reaches a steady state during concentration in a fluid state in which a certain amount of solvent remains.

The above-mentioned extraction extract means a cornus plant which has reached such a state. The extract of the cornus extract is added to an appropriate concentration to prepare a hair growth promoting composition of the present invention.

Extraction of the active ingredient can also be made by cooling or boiling water treatment of dry corn, which is a building material. The extract thus obtained has a natural color of reddish brown or red color and has a unique odor.

The wool composition of the present invention can be used in any form of a solution, tablet or emulsion.

For example, powdered extracts can be used to make any desired formulation, such as hair tonics, hair lotions, hair creams, shampoos and rinses, such as liquid, oil and paste in some manner. In this case, additives commonly used as woolen agents conventionally used, that is, distilled water, alcohols, and polyhydric alcohols as bases can be added. Furthermore, resorcin, salicylic acid, vitamins, nicotinic acid derivatives, photosensitive pigments, Amino acids, fungicides, menthol and other flavors may be contained at the same time.

In particular, by using a combination of ethynyl estradiol and cornus extract extract as a wool composition agent, it significantly improves the hair growth effect than extracting and using only loganin, which is a major component of known cornus, to help prevent hair loss, wool, hair growth, etc. Can be.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, the present invention is not limited only to Examples.

Reference Example 1

Cornus extract 1

300 ml of 95% ethanol was added to 100 mg of cornus oil, and the mixture was warmed at 50 ° C for 120 hours, and then the obtained extract was filtered to obtain 250 ml of the extract. The extract was concentrated to dryness to obtain 22.5 mg of dry extract.

Reference Example 2

Cornus Extract 2

100 mg of cornus oil was extracted with 300 ml of distilled water and treated as in Preparation Example 1 to obtain 30.1 mg of dry extract.

Example 1

Comparative Example 1

Comparative Example 2

Example 2

Example 3

Example 4

[Test Example 1]

Hair growth effect test

Using the prepared hair tonic as a test substance, hairs of 47-53 babies (C57BL / 6, male) were removed, and the back hair was removed, and 10 mice per material group were used. Applied.

The length of hair and the degree of hair growth over time were compared by adding scores according to the degree of restoration after hair removal.

In order to compare the degree of hair growth, 30% aqueous solution of alcohol was applied to each subject to observe the growth state, and the results are shown in Table 7 below.

The results are shown graphically in FIG. 1 and the results of the change in shape are shown in FIG.

As shown in the above test results, when the cornus extract was added to ethynyl estradiol according to the above embodiment, the hair growth promoting effect is proved to be increased, so the composition using the same is expected to promote hair growth in alopecia patients.

[Test Example 2]

Human skin irritation test

In order to determine the degree of skin irritation with respect to the composition according to the present invention, a skin patch test was conducted on 12 subjects of the hair tonic composition according to Example 2.

Observation judged skin response 24 hours or 48 hours after patch.

The test results are shown in Table 8 below.

The sample showed a non-irritant response in human skin irritation test.

In view of the above results, the composition for wool according to the present invention is considered to be a safe material for living organisms without toxicity.

From the above results of the test of the present invention, the wool agent composition of the present invention has a special effect in that it can provide a composition having excellent biosafety and a significant hair growth promoting effect.

Claims (2)

A wool or hair regrowth composition, comprising adding ethynyl estradiol to a cornus extract to increase the hair growth promoting effect. The method of claim 1, wherein the wool or hair tonic, hair tonic, hair lotion, hair cream, shampoo and rinse, such as hair cosmetic formulations and external preparations.