JPS63151860A - Automatic analyzer - Google Patents
Automatic analyzerInfo
- Publication number
- JPS63151860A JPS63151860A JP30026186A JP30026186A JPS63151860A JP S63151860 A JPS63151860 A JP S63151860A JP 30026186 A JP30026186 A JP 30026186A JP 30026186 A JP30026186 A JP 30026186A JP S63151860 A JPS63151860 A JP S63151860A
- Authority
- JP
- Japan
- Prior art keywords
- items
- reinspection
- sample
- measured
- concn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000001704 evaporation Methods 0.000 claims abstract description 7
- 230000008020 evaporation Effects 0.000 claims abstract description 7
- 238000007689 inspection Methods 0.000 claims abstract description 7
- 238000012937 correction Methods 0.000 claims abstract description 3
- 238000013101 initial test Methods 0.000 claims description 17
- 238000013102 re-test Methods 0.000 claims description 17
- 238000004458 analytical method Methods 0.000 claims description 5
- 238000004364 calculation method Methods 0.000 claims description 4
- 238000012360 testing method Methods 0.000 abstract description 19
- 239000007788 liquid Substances 0.000 abstract description 16
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 230000003287 optical effect Effects 0.000 abstract description 2
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 238000005259 measurement Methods 0.000 description 19
- 238000010586 diagram Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 238000000424 optical density measurement Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00603—Reinspection of samples
Landscapes
- Engineering & Computer Science (AREA)
- Quality & Reliability (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
【発明の詳細な説明】
(イ)産業上の利用分野
この発明は自動分析装置に関する。さらに詳しくは血液
、血清、尿等の生体内液を検体とする生化学自動分析装
置であって、任意の項目について再検査しうるよう構成
された自動分析装置に関する。DETAILED DESCRIPTION OF THE INVENTION (a) Field of Industrial Application This invention relates to an automatic analyzer. More specifically, the present invention relates to an automatic biochemical analyzer that uses biological fluids such as blood, serum, urine, etc. as samples, and is configured to be able to reexamine arbitrary items.
(ロ)従来の技術
従来、臨床生化学検査等の分野で用いられている自動分
析装置は、一般に標準の測定条件下で、一定の順序で配
送される多数の検体のそれぞれに対して予め設定された
一連の項目について初回検査を−通り終了した後、これ
らの任意の検体についてのいずれかの項目を再検査しう
るよう構成されたものが知られている。このような装置
においては、ある1つの検体の所定項目について初回検
査での測定値が検体または装置に起因して正常に得られ
ないときは再検査が行われるように構成されている。(B) Conventional technology Conventionally, automatic analyzers used in fields such as clinical biochemical testing generally have preset settings for each of a large number of specimens delivered in a fixed order under standard measurement conditions. A device is known that is configured to be able to retest any of the items on any of these specimens after passing the initial testing on a series of tested items. Such an apparatus is configured such that a re-examination is performed when a measurement value of a predetermined item of a certain specimen cannot be obtained normally in the initial examination due to the specimen or the apparatus.
(ハ)発明が解決しようとする問題点
最近の自動分升の進歩は著しく、採取される検体の微量
化により患者に対する負担度の軽減化には貢献している
が、検体を調製した被検液の取り扱いの面では新たな問
題を抱かえ込むこととなっている。すなわち一連の初回
検査が終了するまでの時間が検体および検査項目の数、
種類によっては非常に長くかかる場合があり、再検査に
うつるまでの間における被検液の濃縮が問題となる。被
検液表面からの水分の蒸発は概ね表面積に比例するから
、被検液量が少なくなればなる程濃縮度が大きくなり臨
床上この誤差は無視できない。(c) Problems to be solved by the invention Recent progress in automatic dispensing has been remarkable, and the amount of specimen collected has been miniaturized, contributing to reducing the burden on patients. This poses new problems in terms of handling liquids. In other words, the time it takes to complete a series of initial tests depends on the number of specimens and test items,
Depending on the type, it may take a very long time, and concentration of the test liquid before it can be retested becomes a problem. Since the evaporation of water from the surface of the test liquid is roughly proportional to the surface area, the smaller the amount of test liquid, the greater the degree of concentration, and this error cannot be ignored clinically.
この発明はかかる状況に鑑みなされたものであり、こと
に再検査される被検液の濃度変化の影響を補償する機能
を有する自動分析装置を提供しようとするものである。The present invention has been made in view of the above circumstances, and particularly aims to provide an automatic analyzer having a function of compensating for the influence of concentration changes in test liquids to be retested.
(ニ)問題点を解決するための手段
かくしてこの発明によれば、一定の順序で配送される多
数の検体のそれぞれに対して予め設定された一連の項目
を測定する多項目分析部を備え、一群の検体についての
初回検査終了後に、これらの任意の検体についてのいず
れかの項目を再検査しうるよう構成された生化学自動分
析装置であって、
選択された任意の検体について再検必要項目とそれ以外
の任意に選択される項目とを並行して再検査することを
実行する制御部と、
上記再検必要項目の再検時の測定値に基づく濃度Aを、
上記他の項目の初回検査時および再検時の測定値a、b
に基づいて下式;
%式%
(式中、A′は補正後の再検必要項目の濃度)により、
再検される検体について初回検査時から再検時までに生
ずる蒸発による濃縮の影響を補正して出力する演算部と
を具備してなる自動分析装置が提供される。(d) Means for Solving the Problems According to the present invention, the present invention includes a multi-item analysis section that measures a series of preset items for each of a large number of samples delivered in a certain order, An automatic biochemical analyzer configured to be able to retest any of the items on any of these samples after the initial test on a group of samples has been completed, and to determine which items require retesting on any selected sample A control unit that executes re-examination of other arbitrarily selected items in parallel, and concentration A based on the measured value at the time of re-examination of the above-mentioned items requiring re-examination,
Measured values a, b of the other items listed above at the initial inspection and re-examination
Based on the following formula: % formula % (In the formula, A' is the concentration of the item requiring re-examination after correction)
An automatic analyzer is provided that includes a calculation unit that corrects and outputs the influence of concentration due to evaporation that occurs from the time of the initial test to the time of the retest for a sample to be retested.
この発明の装置は、検体または装置に起因して初回検査
で正常な測定値が得られない項目を再検査する際、その
検体の正常に測定された項目も共に再検査に付し、この
結果得られる該正常項目の初回検査測定値および再検査
測定値を基準にして、初回検査から再検査まで放置され
る検体に生ずる蒸発による濃度変化動分を補償した再検
査測定値を算出しうるよう構成されたことを特徴とする
。When retesting an item for which a normal measurement value cannot be obtained in the first test due to the specimen or the device, the device of the present invention also subjects the normally measured items of the specimen to the retest, and the results are as follows. Based on the obtained initial test measurement value and retest measurement value of the normal item, it is possible to calculate the retest measurement value that compensates for the concentration change dynamic component due to evaporation that occurs in the specimen that is left unattended from the initial test to the retest. It is characterized by being configured.
通常の分析条件では検体によっては異なるか、測定不可
能な超高値の出現頻度の高い項目として酵素活性項目(
例えばCPK、GOT、GPT。Enzyme activity items (
For example, CPK, GOT, GPT.
LD)I等)が挙げられる。LD) I, etc.).
上記基準用に用いられる項目は、臨床的な見地からみて
濃度変化が小さい(正常値の変動幅が少ない)項目かつ
分析精度の安定した項目が適しており、例えば電解質(
Na” 、K”等)、総タンパク、アルブミン等が挙げ
られる。このような基準用の項目は検体の検査項目を設
定する際に特別に設定されたものであってもよく、また
初回検査時に検査依頼があった項目の中に含まれる場合
それを指定してもよい。From a clinical standpoint, the items used for the above criteria are those with small concentration changes (small fluctuation range of normal values) and items with stable analytical accuracy. For example, electrolytes (
(Na", K", etc.), total protein, albumin, etc. These standard items may be specially set when setting the test items for the specimen, and if they are included in the items requested for testing at the time of the initial test, they may be specified. Good too.
この発明の装置に用いられる演算部において上記濃度変
化分の補償は、比例演算に基づいて行われる。すなわち
上記基準項目の初回測定値(a)と再検査測定値(b)
との比(a/b)に、再検査を必要とする項目の再検査
時の測定値に基づく濃度(A)を乗じることにより、上
記濃度(A)が初回検査時の測定値に基づく濃度に較正
されることとなる。In the arithmetic unit used in the apparatus of the present invention, compensation for the concentration change is performed based on proportional calculation. In other words, the initial measurement value (a) and re-examination measurement value (b) of the above standard items.
By multiplying the ratio (a/b) by the concentration (A) based on the measured value at the time of the re-examination of the item that requires re-examination, the above concentration (A) is the concentration based on the measured value at the initial inspection. It will be calibrated to
(ホ)作用
この発明によれば、所定の検体について再検を必要とさ
れた項目の再検操作時に、該検体についての他の項目が
初回検査時と同一条件で並行して再検され、得られる上
記他の項目についての初回検査測定値と再検測定値との
変化量を、初回検査時から再検時まで放置された検体に
生ずる蒸発による濃縮に起因する測定値変動の基準とし
て、前記再検必要項目の再検測定値に基づく濃度が濃縮
の影響のない状態の濃度に補償して算出される。(E) Effect According to the present invention, when retesting an item that requires retesting for a given specimen, other items of the specimen are retested in parallel under the same conditions as the initial test, and the above results are obtained. The amount of change between the initial test measurement value and the retest measurement value for other items is used as a standard for measurement value fluctuations due to concentration due to evaporation that occurs in specimens left unattended from the initial test to the retest. The concentration based on the retest measurement value is calculated by compensating for the concentration without the influence of concentration.
以下実施例によりこの発明の詳細な説明するが、これに
よりこの発明は限定されるものではない。The present invention will be described in detail below with reference to Examples, but the present invention is not limited thereby.
(へ)実施例
第1図はこの発明の装置の一実施例の構成説明図である
。図において生化学自動分析装置(1)は、多数の反応
容器(2)・・・と、これらの反応容器を駆動部(図示
しない)により矢印方向(ア)に循環移動しうる反応ラ
イン(3)と、サンプラー(41)および検体分注器(
42)を備えた検体供給装置(4)と、意図する分析項
目に対応する多数の試薬を備えた試薬庫(図示しない)
および試薬分注器(51)を備えた試薬、供給装置(5
)と、被検液吸引ノズル(61)に管路接続されたフロ
ーセル(62)を備えた多項目分析用の測光装置(6)
と、反応管内液吸引排出用ノズル(7)と、上記各装置
の作動手順を入力する入力部(81)によりこの生化学
自動分析装置(1)を作動制御するマイクロコンピュー
タを内蔵した制御部(8)と、該制御部(8)に電気接
続され上記測光装置(6)により測定される被検液の光
学濃度測定値を記録する記録部(9)および該測定値を
記憶する記憶部(10)と、該記憶部(10)に電気接
続され記憶された上記測定値から所定の演算に基づいて
演算処理する演算部(11)とから主′として構成され
ている。なお、(12)は洗浄装置、(13)は反応容
器乾燥装置、(14)は反応容器内の測定対象試料を意
図する温度に保持しうる反応槽である。(F) Embodiment FIG. 1 is an explanatory diagram of the configuration of an embodiment of the apparatus of the present invention. In the figure, the biochemical automatic analyzer (1) includes a large number of reaction vessels (2)... and a reaction line (3) that allows these reaction vessels to be circulated in the direction of the arrow (A) by a drive unit (not shown). ), sampler (41) and sample dispenser (
42) and a reagent storage (not shown) equipped with a large number of reagents corresponding to the intended analysis items.
and a reagent and supply device (5) equipped with a reagent dispenser (51).
) and a flow cell (62) connected to a test liquid suction nozzle (61) by a flow cell (62) for multi-item analysis (6)
, a control section (with a built-in microcomputer) that controls the operation of this biochemical automatic analyzer (1) through a nozzle (7) for sucking and discharging the liquid in the reaction tube, and an input section (81) for inputting the operating procedures of each of the above-mentioned devices. 8), a recording section (9) that is electrically connected to the control section (8) and records the optical density measurement value of the test liquid measured by the photometric device (6), and a storage section (9) that stores the measured value. 10), and an arithmetic unit (11) which is electrically connected to the storage unit (10) and performs arithmetic processing based on a predetermined arithmetic operation from the measured values stored. Note that (12) is a cleaning device, (13) is a reaction container drying device, and (14) is a reaction tank capable of maintaining the measurement target sample in the reaction container at an intended temperature.
この生化学自動分析装置(1)により分析を開始するに
あたって、分析対象の一群の検体および各検体に要求さ
れる検査項目を一定の順序で検査しうるよう、これら一
連の項目の検査順序および一群の検体供給順序を予め入
力部(81)に設定する。When starting an analysis using this automatic biochemical analyzer (1), the test order of a series of items and the test items required for each sample are determined in a fixed order. The sample supply order is set in advance in the input section (81).
一群の検体をサンプラー(41)に用意した後、上記入
力手順に従って制御部(8)は検体供給装置(4)およ
び試薬供給装置(5)に作動を指令し、一定の順序で被
検液を調製する。これらの被検液は一定の順序で反応ラ
インにより搬送され順次測光装置(6)により各被検液
の光学濃度が測定される。これらの測定値は順次記録部
(9)および記憶部(10)に出力され、記録されると
ともに記憶される。このようにして一群の検体について
の一連の項目の初回の検査が行われる。上記サンプラー
(41)に用意された一群の検体は、上記一連の初回検
査が終了するまで該サンプラー(41)に放置される。After preparing a group of samples in the sampler (41), the control unit (8) instructs the sample supply device (4) and reagent supply device (5) to operate according to the input procedure described above, and supplies the sample liquid in a fixed order. Prepare. These test liquids are conveyed through the reaction line in a fixed order, and the optical density of each test liquid is sequentially measured by a photometer (6). These measured values are sequentially output to the recording section (9) and the storage section (10), where they are recorded and stored. In this way, the first test of a series of items on a group of specimens is performed. A group of specimens prepared in the sampler (41) is left in the sampler (41) until the series of initial tests are completed.
上記初回検査において、記録部(9)に表示される測定
値が、再検査が必要と判断される場合、初回検査終了後
該当する検体およびその項目(以下再検必要項目)が入
力部(81)に順次設定される。In the above initial test, if the measured value displayed in the recording section (9) is determined to require retesting, the relevant specimen and its items (hereinafter referred to as items requiring retesting) will be displayed in the input section (81) after the initial test. are set sequentially.
このとき該検体について既に測定されている項目のなか
から再検査が不必要と判断される項目(以下再検不必要
項目)を選択して上記再検必要項目と共に測定されるよ
う入力部(81)に設定される。At this time, the input section (81) selects items that are determined to require no retesting from among the items that have already been measured for the sample (hereinafter referred to as items that do not require retesting), and selects them to be measured together with the items that require retesting. Set.
上記設定手順に従って再び前記サンプラー(41)上に
放置されている再検を指定された検体が、上記と同様の
操作で順次被検液に調製され再検操作が順次行われる。According to the setting procedure described above, the specimens designated for retesting and left on the sampler (41) are sequentially prepared into test liquids in the same manner as described above, and retesting operations are sequentially performed.
該操作において、1つの被検液について再検必要項目と
、選択された再検不必要項目が共に測光装置(6)によ
り測定されその結果が記憶部(10)により記憶される
。In this operation, both the items requiring retesting and the selected items not requiring retesting for one test liquid are measured by the photometer (6), and the results are stored in the storage unit (10).
次いで演算部(11)において上記測定された再検必要
項目の濃度(A)は、上記再検不必要項目の既に記憶さ
れている初回検査測定値(a)とこの再検操作により記
憶された再検測定値(b)に基づいて下式;
%式%
により油rxされて−A° として出力されろ−これに
より再検必要項目の再検測定値は、再検までサンプラー
(41)上で放置されていた間に、該検体に生じた蒸発
による濃縮の影響が、同じ影響を有する同一検体の再検
不必要項目の初回検査測定値と再検測定値とを比べるこ
とにより相殺されて、濃縮の影響を補正して出力される
ことになる。Next, in the arithmetic unit (11), the measured concentration (A) of the item requiring retesting is determined by combining the already stored initial test measurement value (a) of the item not requiring retesting and the retest measurement value stored by this retesting operation. Based on the formula below; % formula %, the oil rx is output as -A°.Thus, the retest measurement values for items requiring retesting can be calculated while the values are left on the sampler (41) until the retest. , the effect of concentration due to evaporation that occurs in the sample is offset by comparing the initial test measurement value and retest measurement value of the same sample that has the same effect and does not require retesting, and the effect of concentration is corrected and output. will be done.
(ト)発明の効果
この発明によれば、再検査に伴う検体の濃度変化の影響
を除去することができる。また検体の濃度変化に対する
装置上の特別な配慮、対策が不要となり、信頼性の高い
再検測定値が簡便に得られる。(G) Effects of the Invention According to the present invention, it is possible to eliminate the influence of changes in sample concentration due to retesting. Further, there is no need for special consideration or measures on the device for changes in the concentration of the specimen, and highly reliable retest measurement values can be easily obtained.
第1図はこの発明の自動分析装置の一実施例の構成説明
図である。
(2)・・・・・・反応容器、 (3)・・・・・・
反応ライン、(4)・・・・・・検体供給装置、(5)
・・・・・・試薬供給装置、(6)・・・・・・測光装
置、
(7)・・・・・・反応管内液吸引排出用ノズル、(9
)・・・・・・記録部、 (10)・・・・・・
記憶部、(11)・・・・・・演算部、 (41)
・・・・・・サンプラー、(42)・・・・・・検体分
注器、 (81)・・目・・入力部。FIG. 1 is an explanatory diagram of the configuration of an embodiment of the automatic analyzer of the present invention. (2)・・・・・・Reaction container, (3)・・・・・・
Reaction line, (4)... Sample supply device, (5)
...Reagent supply device, (6) ...Photometer, (7) ...Reaction tube internal liquid suction and discharge nozzle, (9
)... Recording Department, (10)...
Storage unit, (11)...Calculation unit, (41)
... Sampler, (42) ... Sample dispenser, (81) ... Eye... Input section.
Claims (1)
して予め設定された一連の項目を測定する多項目分析部
を備え、一群の検体についての初回検査終了後に、これ
らの任意の検体についてのいずれかの項目を再検査しう
るよう構成された生化学自動分析装置であって、 選択された任意の検体について再検必要項目とそれ以外
の任意に選択される項目とを並行して再検査することを
実行する制御部と、 上記再検必要項目の再検時の測定値に基づく濃度Aを、
上記他の項目の初回検査時および再検時の測定値a、b
に基づいて下式; A^1=A×(a/b) (式中、A^1は補正後の再検必要項目の濃度)により
、再検される検体について初回検査時から再検時までに
生ずる蒸発による濃縮の影響を補正して出力する演算部
とを具備してなる自動分析装置。[Scope of Claims] 1. A multi-item analysis unit that measures a series of preset items for each of a large number of samples delivered in a fixed order, and after completing the initial test on a group of samples, An automatic biochemical analyzer configured to retest any of these items for any sample, including items that require retesting and other arbitrarily selected items for any selected sample. a control unit that executes re-inspection in parallel;
Measured values a, b of the other items listed above at the initial inspection and re-examination
Based on the following formula; A^1 = A x (a/b) (in the formula, A^1 is the concentration of the item that requires retesting after correction), which occurs from the time of the initial test to the time of the retest for the sample to be retested. An automatic analyzer comprising a calculation unit that corrects and outputs the influence of concentration due to evaporation.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP30026186A JPS63151860A (en) | 1986-12-16 | 1986-12-16 | Automatic analyzer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP30026186A JPS63151860A (en) | 1986-12-16 | 1986-12-16 | Automatic analyzer |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS63151860A true JPS63151860A (en) | 1988-06-24 |
Family
ID=17882655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP30026186A Pending JPS63151860A (en) | 1986-12-16 | 1986-12-16 | Automatic analyzer |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS63151860A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014020802A (en) * | 2012-07-12 | 2014-02-03 | Hitachi High-Technologies Corp | Automatic analyzer |
-
1986
- 1986-12-16 JP JP30026186A patent/JPS63151860A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014020802A (en) * | 2012-07-12 | 2014-02-03 | Hitachi High-Technologies Corp | Automatic analyzer |
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