JPS61215318A - External agent for skin - Google Patents

Abstract

PURPOSE:To obtain an external agent for akin, having excellent effect to prevent the discoloration and the lowering of the UV-absorptivity, by compounding 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane with an organic acid and/or it salt. CONSTITUTION:The objective agent can be produced by compounding the compound of formula with an organic acid and/or its salt (e.g. gluconic acid, ascorbic acid, succinic acid, citric acid, lactic acid, tartaric acid, butyric acid, oxalic acid, malonic acid, valeric acid, formic acid, acetic acid, propionic acid, etc.) at a weight ratio of 1:1/5,000-20, preferably 1:1/1,000-10. The base used in the above agent is e.g. cosmetics of solubilized-type, emulsion-type, powder- type, powdery dispersion-type, two phase W/O-type, three phase W/O/ Powdery-type, etc. It may be compound further with a natural extract such as animal or vegetable oil, ester oil, etc., a humectant such as polyhydric alcohol, a thickener such as clay mineral, a preservative, a surfactant, an ultraviolet absorber, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention provides an external preparation for skin that is excellent in preventing discoloration and a decrease in ultraviolet absorption ability, and more specifically, 4-(1,1-dimethylethyl)-4゛-Regarding a skin preparation specially formulated to contain methoxydibenzoylmethane and an organic acid and/or a salt thereof.

4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane has recently been in the spotlight as a UV absorber and an ingredient in external skin preparations such as sunscreens and phanoartions that aim to protect against UV rays. It is growing.

[Prior Art] However, when 4-(1,1-dimethylethyl)-4°-methoxydibenzoylmethane is added alone to a skin preparation, it causes coloration and discoloration over time, significantly impairs the appearance, and damages the skin. Decreases the quality of the product as an external preparation. According to the observations of the present inventors, it also causes a decrease in the UV absorption ability of 4-(1,1-dimethylethyl)-4°-methoxydibenzoylmethane, reducing its effectiveness in protecting against UV rays. Knowledge has been obtained that

Conventionally, in order to prevent discoloration, consideration has been given to toning external skin preparations in advance to make the discoloration and discoloration caused by 4-(1,1-dimethylethyl)-4°-methoxydibenzoylmethane less noticeable. It did not fundamentally solve the problem. Furthermore, there has been no solution to the problem of decreased ultraviolet absorbing ability.

[Problems to be solved by the invention] In view of the above circumstances, the present inventors have conducted intensive research and have found 4-
The present invention was based on the discovery that by blending an organic acid and/or its salt with (1,1-dimethylethyl)-4°-methoxydibenzoylmethane, a skin preparation that simultaneously solves the above problems can be obtained. completed.

[Means for solving the problem] That is, the present invention provides 4-(1,1-dimethylethyl)
-4'-methoxydibenzoylmethane and organic acid and/or
The present invention relates to a skin preparation for external use with little deterioration in quality obtained by incorporating the present invention or a salt thereof.

Hereinafter, the configuration of the present invention will be explained in detail.

4-(1,1-dimethylethyl)- used in the present invention
4°-Methoxydibenzoylmethane is a compound having the structure, and is produced by the method shown in JP-A-55-66535. Also, it is sold by Shibodan Co., Ltd. under the product name ``Pulsol 1789J.''

The amount to be added to the skin external preparation is arbitrary, but if the shape requires consideration of dissolution into the system, it is preferably 20 times or less.

The organic acids and/or their salts used in the present invention include gluconic acid, ascorbic acid, succinic acid, citric acid, lactic acid, tartaric acid, H acid, oxalic acid, malonic acid, valeric acid, formic acid,
Acetic acid, propionic acid, etc. are famous, and one or more of them are blended.

The blending amount is 4-(1,1-dimethylethyl)-4゛-
11500 by weight for methoxydibenzoylmethane
The amount is 0 to 2 times, preferably 1/1 to 10 times. If the amount is less than 115,000 times, the problem will not be solved because the concentration of the organic acid and/or its salt is too dilute. Moreover, if the amount exceeds 20 times, there is no change in the effect and it is uneconomical.

The skin external preparation base containing 4-(1,1-dimethylethyl)-4°-methoxydibenzoylmethane and an organic acid and/or its salt is a skin external preparation base that is commonly thought of, for example, Any base may be used, such as a solubilized type, an emulsified type, a powder type, a powder dispersion type, a water/oil type two-layer cosmetic composition, a water/oil/powder type three-layered cosmetic composition, etc.

The skin external preparation of the present invention may optionally contain natural extracts such as animal and vegetable oils, ester oils, triglycerides, higher fatty acids, and higher alcohols, within a quantitative and qualitative range that does not impair the effects of the present invention. Hydrolic alcohols, other sugar derivatives, humectants such as pyrrolidone carboxylic acid, thickeners such as water-soluble polymer compounds and clay minerals, preservatives, surfactants, sequestering agents, ultraviolet absorbers, inorganic or
Organic powders, pigments, medicinal ingredients, dyes, fragrances, etc. can be added.

[Effects of the Invention] The skin external preparation of the present invention has the following advantages.

When 4-(1,1-dimethylethyl)-4°-methoxydibenzoylmethane is added to a product, it prevents coloring and discoloration over time, and maintains the quality of the product without decreasing its ultraviolet absorption ability. .

[Example] Next, the present invention will be roughly explained in detail using test examples and examples. Note that the present invention is not limited to this.

Test Example 1゜In the sunscreen cream with the following formulation, 4-(1
, 1-dimethylethyl)-4'-methoxydibenzoylmethane 5'% by weight, organic acid and/or its salt 0% by weight, 0.0051i% by weight, 0.01% by weight, 0°05
The coloring of the cream was varied by weight%, 0.1% by weight, and 0.5% by weight, and the discoloration over time was observed.

A.

Setanol 0.5% Vaseline 280 Squalane
7.0 Self-emulsifying monostearin sanglycerin 2.5 Polyoxyethylene sorbitan monostearin ester (20E, O9) 1゜54- (1,1
-dimethylethyl)-4゛-methoxydibenzoylmethane 5.0 Jojoba oil
5. Q.B.

Propylene glycol 5.0 Glycerin 5. ○Vegum (montmorillonite) 5.0 Potassium hydroxide 0.3 Organic acid and/or its salt O~0.5 Water
Residue - Manufacturing method - Heat A (oil phase) and B (aqueous phase) to 70'C,
Completely dissolve. In addition to At-B, emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a sunscreen cream.

Coloring was evaluated immediately after emulsification, and discoloration over time was evaluated after storage at 50'C for one month.

The results are shown in Tables 1 to 3.

Colored (discolored) × Slightly colored (discolored) Δ Not colored (discolored) O Table 2 [In the case of sodium citrate] (Leave blank below) Table 3 (In the case of gluconic acid) Based on the results of Tables 1 to 3 It can be seen that the skin external preparation of the present invention has stable quality without coloration immediately after production or discoloration over time.

(Left below) Test example 2゜Test example 1. The sample used in the above was applied to a quartz glass plate in a thickness of 5 microns, and the ultraviolet absorption spectrum was measured using a spectrophotometer.

Tables 4 to 6 show data on the rate of decrease in the absorption peak of the sample stored at 50'C for one month relative to the absorption bead immediately after sample preparation.

Table-4 (In the case of ascorbic acid) Table-5 (In the case of sodium citrate) (The following is a blank space) Table-6 (In the case of gluconic acid) (The following is a blank space) Example 1 Cream A8 Stearic acid 10.0% stearyl alcohol 4 .0 Butyl stearate 8.0 Stearic acid monoglycerin ester 2.0 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane 2.0 Fragrance
0.4 Preservative appropriate amount B, propylene glycol 10. ○Glycerin 4.0 Maltitol
1.0 potassium hydroxide
0.4 Sodium lactate 0.05 Purified water Heat the remaining oil phase part of A and the water phase part of B to 70°C to completely dissolve them. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain cream.

Example 2 Cream A, Setanol 4.0% Vaseline 7.0 Isobrobyl millinutate 8. .

Squalane 15.0 Stearic acid monoglycerin ester 2.2 POE (20) Sorbitan monostearate 2,8 4-(1,1-dimethylethyl)-4°-methoxydibenzoylmethane 0.5 Fragrance
0.3 antioxidant
Appropriate amount of preservative B, glycerin 1o. ○Dipropylene glycol 5.0 Ascorbic acid 0
．． 01 Purified water Remaining Example 1
A cream was obtained according to.

Example 3 Emulsion A, squalane 5.0% oleyl oleate 3.0 petrolatum
2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene oleyl ether (20E, O,) 1.2 4-(1,1-dimethylethyl)-4°-methoxydibenzoylmethane 1.5 Fragrance
0.3 Preservative appropriate amount B, 1.3 Butylene gellicol 5.0 Ethanol 3.0 Ruboxyvinylborrimer-0.2 Potassium hydroxide 0.1 Sodium citrate 0.05 Purified water
A milky lotion was obtained according to the rest of Example 1.

Example 4 Foundation A, Setanol 3.5% Deodorized Lanolin 4.0 Jojoba Oil
5.0 Vaseline
2.0 Squalane 6.0
Stearic acid monoglycerin ester 2.5 POE (60) Hydrogenated castor oil 1.5 POE (
20) t Chirney 1.04-(1,,1-dimethylethyl)-4'-methoxydibenzoylmethane
8.0 Preservatives Appropriate amount of fragrance
0.3B, propylene glycol 10.0 blended powder
12゜0 citric acid 0.2
Sodium citrate 0.2 Purified water
A foundation was obtained according to the rest of Example 1.

Example 5 Lotion A, ethanol 5.0% POE
Oleyl alcohol ether 2.02-ethylhexyl-P-dimethylaminobenzoate
0.184-(1,1-dimethylethyl)-4
°-methoxydibenzoylmethane 0.02 fragrance
0.05B, 1.3 Butylene glycol 10.0 Glycerin
5.0 Ascorbic acid 0.
4 Purified water Remainder A alcohol
The A phase was added to the aqueous phase B and solubilized to obtain a lotion.

Patent Applicant: Stock Company, Shiseido Proceeding Amendment (Spontaneous) April 1, 1985, 1G, 1, Indication of the Case, 1985 Patent Application No. 56491, 2, Name of the Invention, Skin External Preparation 3, Person Making the Amendment: Related Patent applicant 4, subject of amendment 5゜Engraving of the description of the contents of the amendment (by offset printing, as attached (no change in content))

Claims (1)

[Claims] An external preparation for skin, characterized in that it contains 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane and an organic acid and/or a salt thereof.