JPS60196724A - Cleaner for contact lens - Google Patents

Abstract

PURPOSE:To enable provision of a cleaner for a contact lens and particularly efficient cleaning away of the stains sticking to the contact lens by incorporating >=1 kinds from the group of specific 6 kinds of glycocyl compd. hydrolases into said cleaner. CONSTITUTION:A cleaner for a contact lens is incorporated therein with >=1 kinds among 6 kinds of glycocyl compd. hydrolases including amylase such as alpha-amylase, glulcoamylase, etc., cellulase (''Cell Crust'' produced by Novo Industry Japan, etc.), pectinase (''Pectinase'' produces by Tanabe Pharmaceutical, etc.), alginase (produced by soil bacterium Alginomonas, etc.), heparinase (extracted from the liver of cattle, rabbit, etc.) and dexgrase (produced from mold such as penicillium). The stains in which lipid, mucopolysaccharide, etc. except protein and mucin exist mixedly and which are stuck to the lens are thus hydrolyzed by the above-mentioned enzymes and made removable with high efficiency.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel cleaning agent useful for cleaning contact lenses (IJ), particularly for removing stains attached or adhered to contact lenses.

Contact lenses include hard contact lenses whose main component is methyl methacrylate, soft contact lenses whose main component is 2-hydroxy methacrylate or N-vinyl e-rolidone, and even? There are silicone contact lenses that have been made hydrophilic by surface discharge treatment of resiloxane-based hydrophobic materials. In particular, soft or silicone contact lenses have been widely used in recent years because they are soft, have good oxygen permeability, and have little foreign body sensation when worn on the eyes.

These soft contact lenses tend to become contaminated when worn for long periods of time, and contamination with lipids, proteins, mucins, and bacteria in tear fluid can cloud the contact lenses and cause eye damage.

Lipid stains on contact lenses can be almost completely removed with commonly used contact lens cleaning agents containing surfactants as main ingredients, but protein and mucin cannot be removed with these cleaning agents. Particularly in the case of soft contact lenses, boiling sterilization further denatures and coagulates the protein.
It is necessary to make the contact lenses adhere even more strongly, which in turn shortens the lifespan of the contact lenses.

BACKGROUND ART Cleaning agents containing proteolytic enzymes and hydrosulfohydryl compounds have been known as cleaning agents for regenerating contact lenses contaminated with proteins and mucin substances. Although this cleaning agent is effective in cleaning contact lenses, it has the disadvantage that cleaning takes a very long time.

In addition, there is a method that aims to shorten the time required for cleaning by further adding one or both of urea and guanidine hydrochloride to this cleaning agent. However, since these urea and guanidine hydrochlorides need to be very concentrated in detergents, they have the drawback of requiring labor when preparing detergents from formulations and rinsing after cleaning treatment.

As a result of intensive research into methods for efficiently removing dirt stuck to contact lenses, the present inventors discovered that this purpose can be achieved by cleaning with a cleaning agent containing glycosyl compound hydrolase. , arrived at the present invention.

The present invention relates to a contact lens cleaning agent characterized by containing an effective amount of a glycosyl compound hydrolase selected from the group of amylase, cellulase, pectinase, arginase, helinase, and dextranase.

Examples of the amylase used in the cleaning agent of the present invention include α-amylase, β-amylase, glucoamylase, and isoamylase.

Next, the cellulases used in the present invention include the fungi Triehoderma viride and Aspe.
rgillusniger, Fusarium m.
All the items produced by oniliforme etc.
Nose Industry Japan's Celluclast, Kyowa Hakko's Driselase 20, Ohno Pharmaceutical's Cellulase AP-
4. There are commercially available products such as Meiji Seika's Meicerase. In addition, as pectinase, 5elot1nia L
ibertiana.

Aspergllus niger, Conio
thyrlum diplodiev-11a, and commercially available products include Pectinase Tanape (Tanabe Seiyaku) and Sucrase S (Sankyo).
and Pectinase Toyo (Toyo Jozo). Furthermore, for arginase, marine tube A1 ginovibr
lo, soil bacterium A1ginomonas, Algi
Consists of products produced by nobaater and others. As henogurinase, the microorganism Flavobaetariu
There are two types: those obtained by culturing M. heparlcum and those extracted from the livers of cows, rabbits, and rats. Furthermore, dextranase can be extracted from Penicillium, Ag
pergillus, Verticillium
.

Some are produced from filamentous fungi such as 5picaria.

The amount of glycosyl compound hydrolase used in the cleaning agent of the present invention is 0.005 to 5% by weight, preferably 0.05% by weight.
~1% by weight.

It should be noted that suitable buffers and stabilizers may also be used in the cleaning agent of the present invention, such as sodium or potassium citrate, citric acid, boric acid, disodium edetate, various mixtures of phosphate buffers and bicarbonate. It may also contain sodium.

Generally, the amount of buffering agent and stabilizer used is about 0.000 to 0.000 to 2.000.
5% by weight, preferably in the range of about 0.01-1% by weight. In addition, non-toxic hydrosulfhydryl compounds can also be used, such as sodium sulfate, sodium sulfite, sodium bisulfite, cis9ine hydrochloride, etc.
It can be used in a range of 5% by weight, preferably 0.05 to 1 trillion% by weight.

In addition, in order to make the detergent substantially isotonic, 0.5 to 1.5% of a neutral inorganic salt is added, preferably 0.8 to 1.0% of sodium chloride, which is the main component of lachrymal fluid. It is preferable to do so. The cleaning agent of the present invention is usually used in a liquid form using an aqueous medium, but it can also be used in a powder or solid form. In this case, lubricants, binders and excipients may be included, among which glycerin, sorbitol, zolopyrene glycol, polyethylene glycol, Textran, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose or water-soluble or naturally occurring hydrophilic agents such as gelatin, alginate, tragacanth, pectin, gum acacia, and soluble starch. Those liO,01~10 weight loss, preferably
U O, in the range of 1 to 5% by weight. Furthermore, in the present invention, a protease can also be used in combination with the specified hydrolase.

When the cleaning agent of the present invention is used, the cleaning power is greater than that of conventional cleaning agents containing proteolytic enzymes, and the cleaning time can be shortened. The reason for this is not completely clear, but
The dirt that adheres to contact lenses is thought to be a mixture of proteins, lipids, mucopolysaccharides, etc., which are components of tear fluid, and have been denatured. It is thought that by hydrolyzing with enzymes, the cleaning effect was higher than when cleaning with proteolytic enzymes.

Next, the present invention will be explained in more detail with reference to Examples.

Example 1 α-amylase (Nagase Sangyo) o, o5 Ii, sodium chloride 0. IJF, edetate disodium 0.0
Put 19 in a plastic container, add distilled water to make a total volume of 1OWLl, use it for 6 months, put 1 dirty soft contact lens in it, leave it for about 3 hours, then take out the lens and wash it lightly with water. After that, add 1 to physiological saline.
A cleaned lens was obtained after being left for a period of time.

Example 2 Cellulase (Cellcrust from Nose Industries Japan) 0.04JT, sodium chloride 0.11? , 0.01.9% of sodium citrate was placed in a plastic container, water was added to make 1O-, and the following treatment was carried out in the same manner as in Example 1.
A cleaned lens was obtained.

Example 3 Soluble pectinase Kutanape> (manufactured by Tanabe Pharmaceutical Co., Ltd.) 0.0
8N, Sodium chloride O-I JFs Boric acid 0.0
0.05Jl, sodium bicarbonate 0.011 and edetate disodium 0.01N were placed in a plastic container, water was added to make 10-, and the following treatment was carried out in the same manner as in Example 1.
Obtain a clean lens.

Example 4 Soybean β-amylase (Nagase Sangyo) o, oay.

Nogunoguin (Kanto Chemical) 0.0251. 0.1 p of sodium chloride and 0.01 N of disodium edetate were placed in a plastic container, water was added to make 1 o-, and the mixture was treated in the same manner as in Example 1 to obtain a cleaned lens.

Claims (1)

[Claims] 1. A contact lens cleaning agent characterized by containing at least one glycosyl compound hydrolase selected from the group of amylase, cellulase, pectinase, arginase, heparinase, and dextranase.