Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Denka Co Ltd
Original Assignee
Denki Kagaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denki Kagaku Kogyo KKfiledCriticalDenki Kagaku Kogyo KK
Priority to JP62199144ApriorityCriticalpatent/JPS6442441A/en
Publication of JPS6442441ApublicationCriticalpatent/JPS6442441A/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Abstract
PURPOSE:To obtain a macrophage activator, containing, human lymphotoxin as an active ingredient and capable of imparting chemotaxis to macrophages and accelerating antitumor action. CONSTITUTION:A macrophage activator containing human lymphotoxin (h-LT), preferably rh-LT-1 expressed by formula I (R is formula II) which is h-LT (hereinafter referred to as rh-LT) prepared by using a genetic manipulation technique in aspects of ensuring homogeneous h-LT in an amount so as to enable cancer clinical application, rh-LT-2 expressed by formula III or rh-LT-3 expressed by formula IV as an active ingredient. Methods for activating macrophages collected from an animal abdominal cavity, blood, lung, etc., with the h-LT in.vivo and administering the activated macrophages to a cancerated animal, directly administering the h-LT thereto, accumulating the macrophages in tumorous parts, etc., are used as a method for activating the macrophage and treating cancer.
PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF PATIENTS WITH PROLONGED COAGULATION TIME, METHOD OF TREATING PATIENTS, USING THE EPI INHIBITOR FOR OBTAINING THE PHARMACEUTICAL PREPARATION